DR. PETER JENSEN DR. JESSICA BROWN JOANN … Jessica Brown’s lab I work with Cryptococcus...

31
JULY 1, 2015 VOL.#2 ISSUE #1 1 Letter from the Chair DR. PETER JENSEN PAGE 2 PATHOLOGY NEWS Residency Program DR. CHERYL PALMER PAGE 10 Microbio & Immunology DR. JESSICA BROWN PAGE 4 Pediatric Pathology LANCE ERICKSON PAGE 25 Med Lab Science JOANN FENN PAGE 8 Anatomic Pathology DR. EVIN GULBAHCE PAGE 20 Clinical Pathology PETA OWENS-LISTON PAGE 13 Pathology IT PATH IT DEPT. PAGE 31 Admin Team ERIN BAKE & SARAH BARTH PAGE 28

Transcript of DR. PETER JENSEN DR. JESSICA BROWN JOANN … Jessica Brown’s lab I work with Cryptococcus...

JULY 1 2015 VOL2 ISSUE 1

1

Letter from the Chair

DR PETER JENSEN

PAGE 2

PATHOLOGY NEWS

Residency Program

DR CHERYL PALMER PAGE 10

Microbio amp Immunology

DR JESSICA BROWN

PAGE 4

Pediatric Pathology

LANCE ERICKSON

PAGE 25

Med Lab Science

JOANN FENN PAGE 8

Anatomic Pathology

DR EVIN GULBAHCE

PAGE 20

Clinical Pathology

PETA OWENS-LISTON

PAGE 13

Pathology IT

PATH IT DEPT

PAGE 31

Admin Team

ERIN BAKE amp

SARAH BARTH PAGE 28

JULY 1 2015 VOL2 ISSUE 1

Letter from the Chair BY PETER JENSEN MD

A myriad of exciting initiatives are taking place across the department and ARUP that will each contribute to our goal of improving health care and being leaders in the field of pathology and laboratory medicine One important goal for the upcoming few years is to further build our research programs Discovery and scholarship are essential elements of our identity A large number of faculty and staff are actively involved in

projects that directly impact our ability to deliver cutting edge diagnostic and clinical services A growing number of faculty members lead biomedical research programs that are supported by external grants The field of pathology covers the full breadth of medicine and the scope of our research needs to be broad That said our resources are finite and we need to focus our investments to yield the greatest returns

We are investing in faculty recruitment in the area of Immunology Inflammation and Infectious Diseases (III) This broad field underpins a huge spectrum of human disease and medicine By building a critical mass of III expertise coupled with existing institutional strength in inflammation we hope to provide a foundation for further III recruiting in medicine surgery and pediatrics A key principle will be fit the potential for a new recruit to productively interact with other faculty members as well as the potential to leverage other institutional research initiatives including the Utah Genome Project (for example the genetics of immunological disorders) Neuroscience (Multiple SclerosisNeuroinflammation) MetabolismDiabetes (inflammatory mechanismstype 1 diabetes) cardiovascular (atherosclerosis) and oncology (immunotherapy) Strategic recruitments will be made to catalyze the formation of groups of investigators that share a common interest in specific diseases and pathogenic mechanisms

2

JULY 1 2015 VOL2 ISSUE 1

Another priority is to recruit and foster the development of physician-scientists in pathology We are actively recruiting faculty candidates who will help to bridge our clinical and research programs and our clinical and basic science faculty Wherever possible we would like to take advantage of the special strengths of the University of Utah including ARUP the Huntsman Cancer Institute and our institutional expertise in

genetics to build cohesive disease-focused research programs that will attract new external funding

We also see an opportunity to develop a new program in health services research that would focus on investigating the impact of pathology and laboratory medicine on health care delivery and outcomes This initiative coincides with the establishment of a new Department of Population Health in the School of Medicine and we envision

that Pathology faculty working in this area will collaborate extensively with faculty members in PHS and other departments This program would dovetail beautifully with our efforts to develop data and tools to help University Healthcare and ARUP clients most effectively utilize laboratory services and our access to data from multiple health systems provides an exciting opportunity not available at other institutions

3

PATHOLOGY NEWS

Volume 2 Issue 1 July 2015Dr Cheryl Ann Palmer Editor

Becky Johnson amp William Lowder Associate EditorsContributing Editors Dr Peter Jensen Dr Mary Bronner JoAnn

Fenn Dr Sherrie Perkins Dr Ted Pysher Dr David Stillman Becky Johnson

Photo Credits Dr Meghan Driscoll DrsquoArcy Grenz Becky Johnson Getty Images University of Utah

JULY 1 2015 VOL2 ISSUE 1

Microbiology amp Immunology

Faculty Spotlight Jessica Brown PhD I recently joined the Department of Pathology after completing my postdoctoral studies at the University of California San Francisco I appreciate how welcoming everyone at the U has been especially while getting a new lab up and running My husband and I have been enjoying exploring Utahrsquos beautiful outdoors and

hope to explore further afield this spring and summer

My lab focuses on opportunistic fungal infections These diseases primarily infect patients who are immunocompromised usually due to HIV infection or cancer chemotherapy treatments We are particularly interested in the fungus Cryptococcus

neoformans the primary cause of fungal meningitis worldwide Cryptococcus infections begin in the lungs when patients inhale fungal cells then replicate and spread to the brain My lab is interested in a number of different aspects of the infective process including

1) how C neoformans evades the immune system early in the infective process

2) how C neoformans escapes from the lungs and spreads to the brain and

3) identifying new anti-fungal therapeutics

We also have several exciting collaborations in these areas that makes me appreciate the diversity of the departmentrsquos research programs If you are interested in fungal infections or antimicrobial therapeutics please get in touch

jessicaBrownpathutahedu

4

BY JESSICA BROWN PHD

JULY 1 2015 VOL2 ISSUE 1

MampI Incoming PhD Students

STEVEN DENHAM BROWN LAB

I received a BS in Microbiology from Colorado State University in 2013 before coming to Utah the following year I was attracted to the University of Utah for the same reasons that a lot of people are The program is very committed to student success and the wide breadth of research and high degree of collaboration makes for a great research environment On top of that the outdoors here are just as amazing and accessible as they are in my home state It takes less than a minute for me to leave the lab and start running the trails

In Jessica Brownrsquos lab I work with Cryptococcus neoformans an opportunistic and ubiquitous fungal pathogen responsible for severe morbidity and mortality in immunocompromised individuals Infection is predominantly initiated via inhalation and pulmonary infection but because the fungus is able to escape the lungs and has a strong predilection for the

CNS meningoencephalitis is often the cause of death The process by which C neoformans disseminates and the mechanisms behind its neurotropism are still largely unknown Irsquom interested in learning more about these phenomena by using a mouse model of infection to identify novel genetic factors involved in dissemination

ERIN LARRAGOITE

PLANELLES LAB I am originally from Albuquerque NM and received a BS in Biology from the University of New Mexico in 2014 I was attracted to the University of Utah because of the interesting research collaborative environment and friendly atmosphere The students and faculty members that I met during my interview process expressed a genuine happiness at living in Salt Lake City and conducting research at the University of Utah As a graduate student at the University of Utah I have been able to experience the best of both worlds by having the opportunity to conduct cutting edge research and having the great outdoors right at my doorstep I am currently in Vicente Planellesrsquo lab where I am researching HIV latency reversal in order to determine a mechanism to purge latent HIV reservoirs Specifically my project focuses on dampening T cell activation induced by HIV latency reversing drugs

5

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

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JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

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JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Letter from the Chair BY PETER JENSEN MD

A myriad of exciting initiatives are taking place across the department and ARUP that will each contribute to our goal of improving health care and being leaders in the field of pathology and laboratory medicine One important goal for the upcoming few years is to further build our research programs Discovery and scholarship are essential elements of our identity A large number of faculty and staff are actively involved in

projects that directly impact our ability to deliver cutting edge diagnostic and clinical services A growing number of faculty members lead biomedical research programs that are supported by external grants The field of pathology covers the full breadth of medicine and the scope of our research needs to be broad That said our resources are finite and we need to focus our investments to yield the greatest returns

We are investing in faculty recruitment in the area of Immunology Inflammation and Infectious Diseases (III) This broad field underpins a huge spectrum of human disease and medicine By building a critical mass of III expertise coupled with existing institutional strength in inflammation we hope to provide a foundation for further III recruiting in medicine surgery and pediatrics A key principle will be fit the potential for a new recruit to productively interact with other faculty members as well as the potential to leverage other institutional research initiatives including the Utah Genome Project (for example the genetics of immunological disorders) Neuroscience (Multiple SclerosisNeuroinflammation) MetabolismDiabetes (inflammatory mechanismstype 1 diabetes) cardiovascular (atherosclerosis) and oncology (immunotherapy) Strategic recruitments will be made to catalyze the formation of groups of investigators that share a common interest in specific diseases and pathogenic mechanisms

2

JULY 1 2015 VOL2 ISSUE 1

Another priority is to recruit and foster the development of physician-scientists in pathology We are actively recruiting faculty candidates who will help to bridge our clinical and research programs and our clinical and basic science faculty Wherever possible we would like to take advantage of the special strengths of the University of Utah including ARUP the Huntsman Cancer Institute and our institutional expertise in

genetics to build cohesive disease-focused research programs that will attract new external funding

We also see an opportunity to develop a new program in health services research that would focus on investigating the impact of pathology and laboratory medicine on health care delivery and outcomes This initiative coincides with the establishment of a new Department of Population Health in the School of Medicine and we envision

that Pathology faculty working in this area will collaborate extensively with faculty members in PHS and other departments This program would dovetail beautifully with our efforts to develop data and tools to help University Healthcare and ARUP clients most effectively utilize laboratory services and our access to data from multiple health systems provides an exciting opportunity not available at other institutions

3

PATHOLOGY NEWS

Volume 2 Issue 1 July 2015Dr Cheryl Ann Palmer Editor

Becky Johnson amp William Lowder Associate EditorsContributing Editors Dr Peter Jensen Dr Mary Bronner JoAnn

Fenn Dr Sherrie Perkins Dr Ted Pysher Dr David Stillman Becky Johnson

Photo Credits Dr Meghan Driscoll DrsquoArcy Grenz Becky Johnson Getty Images University of Utah

JULY 1 2015 VOL2 ISSUE 1

Microbiology amp Immunology

Faculty Spotlight Jessica Brown PhD I recently joined the Department of Pathology after completing my postdoctoral studies at the University of California San Francisco I appreciate how welcoming everyone at the U has been especially while getting a new lab up and running My husband and I have been enjoying exploring Utahrsquos beautiful outdoors and

hope to explore further afield this spring and summer

My lab focuses on opportunistic fungal infections These diseases primarily infect patients who are immunocompromised usually due to HIV infection or cancer chemotherapy treatments We are particularly interested in the fungus Cryptococcus

neoformans the primary cause of fungal meningitis worldwide Cryptococcus infections begin in the lungs when patients inhale fungal cells then replicate and spread to the brain My lab is interested in a number of different aspects of the infective process including

1) how C neoformans evades the immune system early in the infective process

2) how C neoformans escapes from the lungs and spreads to the brain and

3) identifying new anti-fungal therapeutics

We also have several exciting collaborations in these areas that makes me appreciate the diversity of the departmentrsquos research programs If you are interested in fungal infections or antimicrobial therapeutics please get in touch

jessicaBrownpathutahedu

4

BY JESSICA BROWN PHD

JULY 1 2015 VOL2 ISSUE 1

MampI Incoming PhD Students

STEVEN DENHAM BROWN LAB

I received a BS in Microbiology from Colorado State University in 2013 before coming to Utah the following year I was attracted to the University of Utah for the same reasons that a lot of people are The program is very committed to student success and the wide breadth of research and high degree of collaboration makes for a great research environment On top of that the outdoors here are just as amazing and accessible as they are in my home state It takes less than a minute for me to leave the lab and start running the trails

In Jessica Brownrsquos lab I work with Cryptococcus neoformans an opportunistic and ubiquitous fungal pathogen responsible for severe morbidity and mortality in immunocompromised individuals Infection is predominantly initiated via inhalation and pulmonary infection but because the fungus is able to escape the lungs and has a strong predilection for the

CNS meningoencephalitis is often the cause of death The process by which C neoformans disseminates and the mechanisms behind its neurotropism are still largely unknown Irsquom interested in learning more about these phenomena by using a mouse model of infection to identify novel genetic factors involved in dissemination

ERIN LARRAGOITE

PLANELLES LAB I am originally from Albuquerque NM and received a BS in Biology from the University of New Mexico in 2014 I was attracted to the University of Utah because of the interesting research collaborative environment and friendly atmosphere The students and faculty members that I met during my interview process expressed a genuine happiness at living in Salt Lake City and conducting research at the University of Utah As a graduate student at the University of Utah I have been able to experience the best of both worlds by having the opportunity to conduct cutting edge research and having the great outdoors right at my doorstep I am currently in Vicente Planellesrsquo lab where I am researching HIV latency reversal in order to determine a mechanism to purge latent HIV reservoirs Specifically my project focuses on dampening T cell activation induced by HIV latency reversing drugs

5

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Another priority is to recruit and foster the development of physician-scientists in pathology We are actively recruiting faculty candidates who will help to bridge our clinical and research programs and our clinical and basic science faculty Wherever possible we would like to take advantage of the special strengths of the University of Utah including ARUP the Huntsman Cancer Institute and our institutional expertise in

genetics to build cohesive disease-focused research programs that will attract new external funding

We also see an opportunity to develop a new program in health services research that would focus on investigating the impact of pathology and laboratory medicine on health care delivery and outcomes This initiative coincides with the establishment of a new Department of Population Health in the School of Medicine and we envision

that Pathology faculty working in this area will collaborate extensively with faculty members in PHS and other departments This program would dovetail beautifully with our efforts to develop data and tools to help University Healthcare and ARUP clients most effectively utilize laboratory services and our access to data from multiple health systems provides an exciting opportunity not available at other institutions

3

PATHOLOGY NEWS

Volume 2 Issue 1 July 2015Dr Cheryl Ann Palmer Editor

Becky Johnson amp William Lowder Associate EditorsContributing Editors Dr Peter Jensen Dr Mary Bronner JoAnn

Fenn Dr Sherrie Perkins Dr Ted Pysher Dr David Stillman Becky Johnson

Photo Credits Dr Meghan Driscoll DrsquoArcy Grenz Becky Johnson Getty Images University of Utah

JULY 1 2015 VOL2 ISSUE 1

Microbiology amp Immunology

Faculty Spotlight Jessica Brown PhD I recently joined the Department of Pathology after completing my postdoctoral studies at the University of California San Francisco I appreciate how welcoming everyone at the U has been especially while getting a new lab up and running My husband and I have been enjoying exploring Utahrsquos beautiful outdoors and

hope to explore further afield this spring and summer

My lab focuses on opportunistic fungal infections These diseases primarily infect patients who are immunocompromised usually due to HIV infection or cancer chemotherapy treatments We are particularly interested in the fungus Cryptococcus

neoformans the primary cause of fungal meningitis worldwide Cryptococcus infections begin in the lungs when patients inhale fungal cells then replicate and spread to the brain My lab is interested in a number of different aspects of the infective process including

1) how C neoformans evades the immune system early in the infective process

2) how C neoformans escapes from the lungs and spreads to the brain and

3) identifying new anti-fungal therapeutics

We also have several exciting collaborations in these areas that makes me appreciate the diversity of the departmentrsquos research programs If you are interested in fungal infections or antimicrobial therapeutics please get in touch

jessicaBrownpathutahedu

4

BY JESSICA BROWN PHD

JULY 1 2015 VOL2 ISSUE 1

MampI Incoming PhD Students

STEVEN DENHAM BROWN LAB

I received a BS in Microbiology from Colorado State University in 2013 before coming to Utah the following year I was attracted to the University of Utah for the same reasons that a lot of people are The program is very committed to student success and the wide breadth of research and high degree of collaboration makes for a great research environment On top of that the outdoors here are just as amazing and accessible as they are in my home state It takes less than a minute for me to leave the lab and start running the trails

In Jessica Brownrsquos lab I work with Cryptococcus neoformans an opportunistic and ubiquitous fungal pathogen responsible for severe morbidity and mortality in immunocompromised individuals Infection is predominantly initiated via inhalation and pulmonary infection but because the fungus is able to escape the lungs and has a strong predilection for the

CNS meningoencephalitis is often the cause of death The process by which C neoformans disseminates and the mechanisms behind its neurotropism are still largely unknown Irsquom interested in learning more about these phenomena by using a mouse model of infection to identify novel genetic factors involved in dissemination

ERIN LARRAGOITE

PLANELLES LAB I am originally from Albuquerque NM and received a BS in Biology from the University of New Mexico in 2014 I was attracted to the University of Utah because of the interesting research collaborative environment and friendly atmosphere The students and faculty members that I met during my interview process expressed a genuine happiness at living in Salt Lake City and conducting research at the University of Utah As a graduate student at the University of Utah I have been able to experience the best of both worlds by having the opportunity to conduct cutting edge research and having the great outdoors right at my doorstep I am currently in Vicente Planellesrsquo lab where I am researching HIV latency reversal in order to determine a mechanism to purge latent HIV reservoirs Specifically my project focuses on dampening T cell activation induced by HIV latency reversing drugs

5

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Microbiology amp Immunology

Faculty Spotlight Jessica Brown PhD I recently joined the Department of Pathology after completing my postdoctoral studies at the University of California San Francisco I appreciate how welcoming everyone at the U has been especially while getting a new lab up and running My husband and I have been enjoying exploring Utahrsquos beautiful outdoors and

hope to explore further afield this spring and summer

My lab focuses on opportunistic fungal infections These diseases primarily infect patients who are immunocompromised usually due to HIV infection or cancer chemotherapy treatments We are particularly interested in the fungus Cryptococcus

neoformans the primary cause of fungal meningitis worldwide Cryptococcus infections begin in the lungs when patients inhale fungal cells then replicate and spread to the brain My lab is interested in a number of different aspects of the infective process including

1) how C neoformans evades the immune system early in the infective process

2) how C neoformans escapes from the lungs and spreads to the brain and

3) identifying new anti-fungal therapeutics

We also have several exciting collaborations in these areas that makes me appreciate the diversity of the departmentrsquos research programs If you are interested in fungal infections or antimicrobial therapeutics please get in touch

jessicaBrownpathutahedu

4

BY JESSICA BROWN PHD

JULY 1 2015 VOL2 ISSUE 1

MampI Incoming PhD Students

STEVEN DENHAM BROWN LAB

I received a BS in Microbiology from Colorado State University in 2013 before coming to Utah the following year I was attracted to the University of Utah for the same reasons that a lot of people are The program is very committed to student success and the wide breadth of research and high degree of collaboration makes for a great research environment On top of that the outdoors here are just as amazing and accessible as they are in my home state It takes less than a minute for me to leave the lab and start running the trails

In Jessica Brownrsquos lab I work with Cryptococcus neoformans an opportunistic and ubiquitous fungal pathogen responsible for severe morbidity and mortality in immunocompromised individuals Infection is predominantly initiated via inhalation and pulmonary infection but because the fungus is able to escape the lungs and has a strong predilection for the

CNS meningoencephalitis is often the cause of death The process by which C neoformans disseminates and the mechanisms behind its neurotropism are still largely unknown Irsquom interested in learning more about these phenomena by using a mouse model of infection to identify novel genetic factors involved in dissemination

ERIN LARRAGOITE

PLANELLES LAB I am originally from Albuquerque NM and received a BS in Biology from the University of New Mexico in 2014 I was attracted to the University of Utah because of the interesting research collaborative environment and friendly atmosphere The students and faculty members that I met during my interview process expressed a genuine happiness at living in Salt Lake City and conducting research at the University of Utah As a graduate student at the University of Utah I have been able to experience the best of both worlds by having the opportunity to conduct cutting edge research and having the great outdoors right at my doorstep I am currently in Vicente Planellesrsquo lab where I am researching HIV latency reversal in order to determine a mechanism to purge latent HIV reservoirs Specifically my project focuses on dampening T cell activation induced by HIV latency reversing drugs

5

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

MampI Incoming PhD Students

STEVEN DENHAM BROWN LAB

I received a BS in Microbiology from Colorado State University in 2013 before coming to Utah the following year I was attracted to the University of Utah for the same reasons that a lot of people are The program is very committed to student success and the wide breadth of research and high degree of collaboration makes for a great research environment On top of that the outdoors here are just as amazing and accessible as they are in my home state It takes less than a minute for me to leave the lab and start running the trails

In Jessica Brownrsquos lab I work with Cryptococcus neoformans an opportunistic and ubiquitous fungal pathogen responsible for severe morbidity and mortality in immunocompromised individuals Infection is predominantly initiated via inhalation and pulmonary infection but because the fungus is able to escape the lungs and has a strong predilection for the

CNS meningoencephalitis is often the cause of death The process by which C neoformans disseminates and the mechanisms behind its neurotropism are still largely unknown Irsquom interested in learning more about these phenomena by using a mouse model of infection to identify novel genetic factors involved in dissemination

ERIN LARRAGOITE

PLANELLES LAB I am originally from Albuquerque NM and received a BS in Biology from the University of New Mexico in 2014 I was attracted to the University of Utah because of the interesting research collaborative environment and friendly atmosphere The students and faculty members that I met during my interview process expressed a genuine happiness at living in Salt Lake City and conducting research at the University of Utah As a graduate student at the University of Utah I have been able to experience the best of both worlds by having the opportunity to conduct cutting edge research and having the great outdoors right at my doorstep I am currently in Vicente Planellesrsquo lab where I am researching HIV latency reversal in order to determine a mechanism to purge latent HIV reservoirs Specifically my project focuses on dampening T cell activation induced by HIV latency reversing drugs

5

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

GARRETT BROWN

ROUND LAB I am originally from Louisville Kentucky where I completed a BS in biology at the University of Louisville As an undergraduate I participated in research relating to the evolution amp ecology of the Pseudomonas genus of bacteria When applying for graduate school I was unsure of what specific line of research I wanted to pursue My uncertainty drew me to the University of Utah the diversity of research here is incredible and I knew that continuing my education here would certainly allow me to find a niche that fascinated me After completing a year of rotations I decided to join the Round Lab which is generally focused on how the gut flora of mammals the microbiota influences various aspects of health and disease Specifically I plan to research how bacteriophages can be used to modulate bacterial community structures and the effects that this can have on the mammalian host

VRUSHALI MANGALE LANE LAB

I completed my bachelorrsquos in Biotechnology in India and moved to pursue a Masterrsquos in Molecular Biology at San Diego State University After completing my Masterrsquos I joined the Pathology department through the Molecular Biology PhD program Pursuing a PhD at the University of Utah was an attractive option for me because of the diverse research opportunities available and the immediate access to the mountains Due to my interest in immunology and translational science I decided to join Tom Lanersquos lab to carry out my PhD thesis

In the Lane lab we study the human demyelinating disease multiple sclerosis (MS) using a viral model (JHMV) that causes demyelination in mice Part of the lab is involved in designing stem cell therapies that promote remyelination in demyelinated axons Particularly my project focuses on the use of mouse induced pluripotent stem cell (iPSC) derived neural progenitor cells (NPCs) as a possible therapy for demyelinated axons

6

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

JOSH DAUGHERTY

LANE LAB I received my BS from the University of Missouri St Louis in 2014 Irsquom a return student married and a father of 4 I spent my earlier youth as a union carpenter and worked on some amazing structures the coolest being a wooden roller coaster After a few injuries and the financial collapse in 2007 I decided to return to academics I chose to come to the University of Utah because of the excellent faculty and projects as well as the collaborative environment Salt Lake has also become an excellent place to call home for me and my family

ALICIA EUSTES WEYRICH LAB

I completed my Bachelorrsquos degree at the University of Wyoming in microbiology I fell in love with science and wanted to continue my education in graduate school Coming to the University of Utah was the right choice for me because everyone here is welcoming and passionate about their research I also love having the mountains at my back door

I work in the Weyrich lab where we work with platelets and megakaryocytes During my studies I will look at the production of microparticles and exosomes during different disease conditions such as dengue and sepsis

MORGAN WAMBAUGH BROWN LAB

I am from a small town in Pennsylvannia and got my BS from Ursinus College I came to the University of Utah because of its emphasis on collaborations as well as the amount of support given to the students here from various faculty and staff I am in Jessica Brownrsquos lab working on finding synergistic drug combinations that can better treat pathogens with an emphasis on the opportunistic fungal pathogen Cryptococcus neoformans

7

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Medical Laboratory Science

Faculty Spotlight JoAnn Fenn MS MASCP MT (ASCP) In representing the Medical Laboratory Science Division I was asked to give information about the division that others may not be aware of I was also asked to share highlights of my career in the Department of Pathology as I am retiring the end of December For the record I think the first request is noteworthy and far more interesting than the second

DIVISION INFORMATION

1 Our faculty members are significantly impacted by the newer university requirements for mandatory undergraduate orientation and advising sessions Each new student on campus must attend a mandatory orientation and we are required to participate as well Also any declared Pre-MLS major must attend a first year and second year formal one-on-one mandatory advising session with a faculty member In addition to mandatory advising many pre-MLS students seek additional advising for course planning With increased interest in the major we accommodate increased numbers of students This is challenging but also offers opportunities to interact more with potential applicants

2 The primary role of our faculty is to administer and teach education programs in Medical Laboratory Science and Cytotechnology (BS levels) and Laboratory Medicine and Biomedical Science (MS level) What may not be known is that faculty also participate in teaching courses or sessions for

students outside of the MLS division

-Pathology 3100 ndash Introduction to Medical Microbiology ndash for 150 pre-nursing and pre-pharmacy students each semester

-Coordination of the Host and Defense microbiology laboratory sessions for first year medical students

8

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

-A significant number of statistics lectures for the neuroscience program pharmacytoxicology and dental school

-Microscopy and urinalysis laboratory sessions for nursing graduate students and physician assistant students

-Basic immunohematology laboratory techniques sessions for pathology residents

-Blood smear preparation sessions for first year medical students

3 In addition to classes and laboratory sessions taught at the university faculty direct formal clinical rotation courses in their given areas of teaching responsibility For clinical rotations we work closely with the education coordinators and bench instructors at each clinical site to create and update objectives study questions learning activities and examinations The support and input from our clinical colleagues truly enhances and elevates the program

CAREER HIGHLIGHTS

I have been a faculty member since 1983 My passion has been program development and improvement as well as teaching microbiology Here are some highlights that I will take with me Most include working with others which has been most gratifying

-Transferring the medical technology program from College of Pharmacy to Department of Pathology and then developing a new curriculum and program structure

-Co-directing the MS program for many years working with 112 graduates

-Working to increase numbers of BS MLS students from 12 to 40 admissionsyear

-Surviving an explosion in the old SOM teaching laboratory with only minor injuries

-Planning with architects for an incredible student laboratory facility for MLS in the Health Science Education Building

-Seeing graduates of BS and MS programs move on to productive careers in the laboratory medicine research and academics

-Participating with ASCP and UofU Global Health and travel to several African countries Vietnam and Cambodia for curriculum review of laboratory training programs and enhancement of teaching methodologies for faculty

-Serving on the ASCP Joint Generalist Examination Committee for 7 years

-Working with three different department chairs and colleagues in the division to fulfill our education mission

A PERSONAL NOTE

So many of you have influenced me whether in small ways or significant interactions I thank you for your patience mentorship and collegiality

BY JOANN FENN MS MASCP MT (ASCP)

9

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Residency Program BY CHERYL ANN PALMER MD

MEET OUR NEW CHIEF RESIDENTS

Many13 of13 you13 have13 had13 the13 opportunity13 to13 meet13 our13 new13 PGY-shy‐413 Chief13 Residents13 for13 2015-shy‐201613 13 Dr13 Isaac13 Lloyd13 is13 our13 Chief13 Resident13 for13 AP13 13 He13 is13 a13 Salt13 Lake13 City13 native13 with13 a13 Bachelorrsquos13 degree13 in13 Biomedical13 Engineering13 magna13 cum13 laude13 from13 the13 University13 of13 Utah13 13 A13 brief13 foray13 to13 the13 Midwest13 gained13 him13 an13 MD13 from13 the13 Medical13 College13 of13 Wisconsin13 but13 he13 returned13 to13 UUHC13 for13 his13 APCP13 residency13 13 Isaac13 enjoys13 hiking13 mountain13 biking13 kayaking13 and13 rafting13 but13 most13 of13 all13 spending13 time13 with13 his13 family13 when13 he13 is13 not13 working13 13 Dr13 Meghan13 Driscoll13 our13 Chief13 for13 CP13 is13 a13 native13 of13 Wyoming13 and13 matriculated13 from13 the13 University13 of13 Wyoming13 where13 she13 received13 a13 Bachelorrsquos13 Degree13 in13 Health13 Science13 with13 a13 minor13 in13 Chemistry13 13 Before13 medical13 school13 at13 the13 University13 of13 Washington13 in13 Seattle13 Meghan13 served13 a13 stint13 at13 one13 of13 the13 NIH13 satellite13 laboratories13

10

Photo (left to right) Issac Lloyd Meghan Driscoll

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

studying13 diabetes13 in13 the13 Pima13 Indians13 13 Meghan13 loves13 Utah13 and13 the13 outdoor13 activities13 it13 avails13 including13 hiking13 snowboarding13 and13 biking13 13 Meghan13 and13 Isaac13 would13 be13 more13 than13 happy13 to13 answer13 any13 residency-shy‐related13 questions13 that13 arise13 throughout13 this13 year13

MEET OUR INCOMING INTERNS

We13 have13 Vive13 new13 APCP13 interns13 and13 one13 new13 AP-shy‐only13 intern13 beginning13 this13 month13 13 KATHERINE BOYLAN MD Dr13 Katherine13 Boylan13 comes13 to13 us13 from13 Florida13 where13 she13 just13 graduated13 from13 Schmidt13 College13 of13 Medicine13 at13 Florida13 Atlantic13 University13 after13 a13 magna13 cum13 laude13 degree13 in13 biology13 and13 psychology13 from13 the13 University13 of13 Florida13 13 She13 enjoys13 cooking13 baking13 rock13 climbing13 painting13 and13 photography13 13

JESSICA COREAN MD Dr13 Jessica13 Corean13 is13 a13 North13 Dakota13 native13 13 After13 earning13 her13 Bachelorrsquos13 from13 the13 University13 of13 Montana13 with13 high13 honors13 she13 obtained13 her13 MD13 from13 the13 University13 of13 North13 Dakota13 13 She13 and13 her13 husband13 are13 looking13 forward13 to13 outdoors13 activities13 with13 their13 two13 dogs13 here13 in13 Utah13

NICOLE GIRARD MD Our13 AP-shy‐only13 intern13 Dr13 Nicole13 Girard13 is13 no13 stranger13 to13 pathology13 or13 Utah13 13 13 Having13 prior13 employment13 at13 IMC13 as13 a13 PA13 Nicole13 served13 as13 a13 captain13 in13 the13 US13 Army13 and13 was13 deployed13 for13 Operation13 Iraqi13 Freedom13 13 A13 graduate13 of13 Weber13 State13 University13 and13 the13 Medical13 University13 of13 the13 Americas13 Nicole13 just13 completed13 an13 internship13 in13 Internal13 Medicine13 in13 Oklahoma13 and13 is13 delighted13 to13 be13 back13 in13 Salt13 Lake13 City13

11

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

13 AMANDA HO MD Born13 in13 Texas13 Dr13 Amanda13 Ho13 received13 a13 Bachelorrsquos13 in13 Cognitive13 Sciences13 from13 Rice13 University13 and13 her13 MD13 from13 the13 University13 of13 Texas13 at13 Southwestern13 13 She13 lives13 a13 well-shy‐rounded13 life13 enjoying13 skiing13 mountain13 biking13 hiking13 camping13 geocaching13 and13 photography13 13 It13 is13 a13 safe13 bet13 she13 will13 Vind13 plenty13 of13 these13 hobbies13 to13 explore13 here13

13 JEFFREY MOHLMAN MD A13 Provo13 native13 Dr13 Jeffrey13 Mohlman13 rotated13 with13 us13 last13 fall13 while13 enrolled13 as13 a13 medical13 student13 at13 Texas13 Tech13 in13 El13 Paso13 13 In13 addition13 to13 his13 MD13 he13 has13 accrued13 a13 Bachelorrsquos13 in13 Exercise13 Science13 from13 BYU13 and13 an13 MPH13 from13 the13 University13 of13 Texas13 13 Jeff13 has13 family13 in13 Utah13 and13 is13 happy13 to13 join13 our13 program13 13

BRITTANY YOUNG MD PHD Dr13 Brittany13 Young13 is13 an13 MDPhD13 from13 St13 Louis13 University13 13 With13 a13 Bachelorrsquos13 in13 Biology13 and13 Spanish13 awarded13 summa13 cum13 laude13 from13 Creighton13 she13 entered13 the13 joint13 degree13 program13 13 Meshing13 well13 with13 her13 chosen13 residency13 Brittanyrsquos13 PhD13 is13 in13 Molecular13 Microbiology13 and13 Immunology13 13 She13 enjoys13 watching13 sports13 especially13 football13 and13 has13 already13 begun13 exploring13 her13 new13 environment13

12

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology

ldquoSpeak What You Think So I Can Learnrdquo From Origin to the Newest Edition the Body Fluid Book

BY PETA OWENS-LISTON The go-to-book for body fluids Kjeldsbergrsquos Body Fluid Analysis (4th edition) was recently updated and released by the American Society for Clinical Pathology Press (ASCP) It was co-edited by Jerry Hussong MD DDS

MS the chief medical officer at ARUP Laboratories and Carl Kjeldsberg MD one of ARUPrsquos founders and the bookrsquos original author who is also the author of Practical Diagnosis of Hematologic Disorders

While it has been one of the publisherrsquos bestselling books for yearsmdashsold worldwide and in an electronic versionmdashit was long overdue for an update from the last edition published in 1993 with Joseph Knight MD as the co-author

People in the field were increasingly asking for an updated version

ldquoAreas have become so much more specialized since the last edition so we needed to tap into all the different areas of expertise found among our faculty at ARUP and the University of Utahrdquo says Hussong Each chapter is authored by a well-known expert in that specialty ASCP has also published a companion piece titled Body Fluids Morphology Bench Guide

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood) and

13

Photo (from left to right) Carl Kjeldsberg Jerry Hussong

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

includes new chapters covering urine and specialized body fluids such as vitreous fluid and sweat It was updated to match the new technologies (ie PCRs NGS mass spectrometry) and emphasizes the chemical evaluation of body fluids

It is one of the few fluids books available that goes beyond morphology and features extensive new ancillary methods in cytogenetics flow cytometry IHC and molecular analysis

ldquoWe wanted to keep it a size and at a level that would appeal to a wide spectrum of peoplerdquo states Hussong Avoiding an ldquoencyclopediardquo feel the book is filled with cellular images taken by Kjeldsberg and according to the publisher provides ldquosufficient information for practical applicationsrdquo

Every chapter features lists of key points artifacts and pitfalls with an entire chapter dedicated to specimen

requirements methodological techniques tables of antibodies and antigens of diagnostic use decision making and use of methods

THE BIRTH OF THE ORIGINAL

BODY FLUIDS BOOK13

Early in the 1980s technologists would come in and ask Kjeldsberg to take a look at a spinal amniotic or other kind of fluid specimen to help them understand what they were seeing ldquoSo Irsquod go take a look and figure it out I was doing this every day and was becoming a resourcerdquo recalls Kjeldsberg

One day while looking through a microscope to determine whether cancer cells were present the technologist standing next to him said ldquoSpeakrdquo

Without looking up Kjeldsberg asked ldquoSpeak whatrdquo13

ldquoSpeak what you think so I can learnrdquo commanded the technologist

Thus the idea for the book was borne

The bookrsquos contributors include ARUP faculty Hussong JW Kjeldsberg CR Sorensen E Perkins SL Couturier MR Grenache DG Lamb AN Straseski JA and Cohen MB as well as University of Utah and IVF amp Andrology Laboratories faculty Carrell DT Emery BR Farley JD and Shamsi MB

14

In a simple straightforward approach the book discusses how to analyze different kinds of fluids (except blood)

and includes new chapters covering urine

and specialized body fluids such as vitreous

fluid and sweat

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Dr Schlaberg Helps Innovate New Sequence-Based Infectious Disease Testing

BY PETA OWENS-LISTON

On his laptop Robert Schlaberg MD MPH pulls up a web program displaying a colorful pie chart based on a series of sequencing data from a patient in a Harvard study ldquoAs you can see this shows us a very high-level view of what microbes are present in the patientrsquos samplerdquo says

Schlaberg who specializes in molecular infectious disease testing

He clicks on a slice of the pie titled ldquoVirusesrdquo and what looks like tree rings appear instantly classifying all viral sequences Click Another slice of the pie labeled ldquoBacteriardquo presents a new set

of tree rings designating different classes of bacteria

Behind these easy-to-navigate visuals is the processing of a mountain of highly dense DNA sequencing data Schlaberg and his colleague Mark Yandell PhD a professor of human genetics and the co-director of the

15

Significantly faster than conventional software Dr Schlaberg and his multidisciplinary collaborators have succeeded in developing a program that provides quick turnaround time

and ease of use and still allows for rich taxonomic detail to be mined from patient specimens

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

USTAR Center for Genetic Discovery developed this new molecular testing technology known as Taxonomer

Taxonomer which utilizes metagenomics data to assist in clinical diagnosis and infectious disease discovery tapped into the expertise of a diverse cadre of investigators including members of the University of Utahrsquos departments of Human Genetics Pathology Pediatrics and Biomedical Informatics along with members of the Centers for Disease Control and Prevention and ARUP Laboratories Funding stemmed from the Primary Childrenrsquos Hospital Foundation The Ursquos Center for Clinical and Translational Science and the Ursquos Department of Pathology

ldquoWe wanted a lsquocatch-allrsquo test that can tell you any infection you might have to take the guessing out of infectious disease testingrdquo explains Schlaberg ldquoBy generating genome sequence from any bacteria virus or fungus in a patient sample we can devise such a lsquocatch-allrsquo test by quickly comparing these genome sequences to large reference databasesrdquo Many of

the samples that allow for extensive benchmarking come from colleagues at the CDC and from ARUP Laboratories

DESIGNED FOR NEXT GENERATION OF MEDICAL TESTS

While similar lsquocatch-allrsquo tests have been used in the past to study infectious disease outbreaks the data analysis was not suitable for use in a diagnostic laboratory analysis of millions of DNA sequences took days to weeks results were often difficult to interpret and not of sufficient accuracy By solving these problems Taxonomer takes molecular infectious disease testing to a whole new level and enables use of this testing approach by diagnostic laboratories Schlaberg anticipates that the remaining hurdles for wide diagnostic application will be solved by faster and cheaper sequencing instruments

ldquoTaxonomer is also the only ultrafast metagenomics tool that quantifies human mRNA transcripts which can be used to study the patientrsquos immune response to an infectionrdquo explains Schlaberg In the future this information could be used to differentiate true infections where the patientrsquos

immune response is active from mere shedding of a virus or bacteria that is unrelated to the patientrsquos symptoms it could also be used to differentiate patients with bacterial infections needing antibiotics from those with viral infections

Originally from Germany Schlaberg earned his doctor of medicine degrees at Julius-Maximillians University in Wuerzburg He spent five years in New York City during residency training at Columbia University where he also earned a master of public health at the Mailman School of Public Health In 2009 he moved to Salt Lake City where he joined ARUP as a medical director overseeing the Microbial Amplified Detection Virology and Fecal Chemistry laboratories He also serves as an assistant professor of clinical pathology at the University of Utah

ldquoHaving grown up in the foothills of the Alps I enjoy being here in Salt Lake City near the mountainsrdquo says Schlaberg who spends as much time as he can in the mountains biking backcountry skiing and hiking

16

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Regulatory News

Senate Passes Act to End ldquoDoc Fixrdquo Bills On April 14 2015 clinical laboratoriesmdashas well as physicians and hospitalsmdashreceived excellent news when the US Senate passed the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) repealing the Sustainable Growth Rate (SGR) formula Republicans and Democrats worked together to fix the flawed 1997 law

President Barak Obama signed the bill on April 16 2015 Rather than waiting for a formal ceremony the President noted the need for

immediate action The SGR permanent fix contains no cuts to the Clinical Laboratory Fee Schedule and does not implement beneficiary cost sharing on lab services

ARUP and ACLA (American Clinical Laboratory Association) were active in communicating with Congress the importance of passing the Medicare Access and CHIP Reauthorization Act of 2015 (HR 2) and its impact on health care

ldquoThis is great news Not only will physicians no longer have

to fear a reduction in reimbursement payments but areas considered for alternative cutsmdashlaboratories and hospitalsmdashwill no longer be put on the chopping block insteadrdquo says Dr Edward Ashwood Associate Vice President for Government RelationsARUP and Vice Chair Health Policy for the Department of Pathology He points out that Sen Orrin Hatch was instrumental in helping the bill pass The senator toured ARUP Laboratories several years ago and was very impressed with our commitment to patient

care

ldquoPassage of a permanent SGR puts an end to the perennial lsquodoc fixrsquo bills that temporarily patched the broken systemrdquo said Alan Mertz President of ACLA ldquoThese lsquodoc fixrsquo patches were sometimes at the expense of laboratories which were used as a pay for temporary fixesrdquo

17

President Obama signing $200 billion Medicare reform package

httpthehillcomhomenewsadministration239165-obama-signs-200b-doc-fix-bill

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Incoming Clinical Pathology Fellows

SALIKA M SHAKIR PHD MEDICAL MICROBIOLOGY

Salika is originally from Bangalore India where she obtained a Bachelors of Science in Microbiology and Chemistry She moved to Oklahoma City in 2004 and pursued her PhD in Microbiology and Immunology at the University of Oklahoma Health Sciences Center She graduated in 2010 with a doctoral dissertation on the serinethreonine kinase-phosphatase system in Bacillus anthracis Salika pursued her interest in pediatric infectious diseases as a post-doctoral fellow working on the intestinal translocation of neonatal Ecoli sepsis isolates Outside of work Salika enjoys baking traveling hiking and spending time with her husband and two boys

COLLEEN M CARLSTON PHD CLINICAL MOLECULAR GENETICS

Colleen was born and raised in the San Francisco Bay area She graduated from Harvard University in 2009 with a BA in Biology and Japanese Language Citation She then entered a PhD program in Molecular Biology and Genetics at the Cold Spring Harbor Laboratoryrsquos Watson School of Biological Sciences Her thesis work focused on how a prion-like protein (PQN-59) regulates development of C elegans She is joining the Clinical Molecular Genetics Fellowship in July 2015 Colleen is excited to move to Utah as she is a big fan of hiking and looks forward to enjoying the many outdoor activities available in this area

18

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Clinical Pathology Division Updates

Elizabeth Frank PhD has been nominated to run for President-elect of the American Association for Clinical Chemistry The election will take place in September Itrsquos an honor to be nominated by your peers for this position and we are proud of her (Not public yet)

David Hillyard MD Elected as fellow of the National Academy of Inventors

Carl Wittwer MD PhD

1 Grant Fluorescent DNA Amplification Techniques July 1 2015 - June 30 2020 $47M BioFire Diagnostics

2 Grant Genetic Assay Development March 15 2015 - March 14 2016 $390K Canon US Life Sciences

3 Academic Senior Editor (along with Nader Rafai and Rita Horvath) for the 6th edition of Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 2016

4 Award Lifetime Achievement Honoree Utah Genius Awards May 6th 2015 httputahgeniuscom

5 Award Science and Technology Development recipient of the Pioneers of Progress Award Days of 47 Inc July 15 2015 httpwwwdaysof47comeventspioneers-of-progress

Elaine Lyon PhD received the Jeffrey A Kant Leadership Award from the Association for Molecular Pathology (AMP) in November Here is the description

AMPs highest award bestowed to an AMP member who has demonstrated exceptional leadership in the accomplishment of the mission and goals of AMP This is one means for all AMP members to publicly honor the exceptional accomplishments and notable contributions of an individual who has demonstrated vision and direction for both AMP and the field of molecular pathology

In January Lyon was invited to an event at the White House with President Obama as he rolled out his Precision Medicine Initiative For more information visit httpswwwwhitehousegovthe-press-office20150130fact-sheet-president-obama-s-precision-medicine-initiative

19

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Anatomic Pathology

Faculty Spotlight Evin Gulbahce MD H Evin Gulbahce MD has been working in the Department of Pathology University of Utah for the past two years She is an anatomic pathologist and helps cover service in surgical pathology cytology (FNA service) and FISH Gulbahce also teaches pathology residents fellows medical students and dental students She is currently overseeing the Biorepository and Molecularly Pathology (BMP) along with Dr Mary Bronner BMP a shared resource at Huntsman Cancer Center has three distinct sections Biorepository Research Histology and Molecular Diagnostics Biorepository is responsible for collecting storing tracking processing and distributing human tissue and blood biospecimens to cancer researchers The College of American Pathologists (CAP) Certified Biorepository currently tracks more than 30000 specimens through a Biospecimen Tracking Database called itBioPath which links important clinical and pathological information with collected specimens Cancer specimens of all types are collected by the Biorepository under IRB 10924 Molecular Classifications of Cancer The majority (gt90) of cancer patients undergoing surgery at Huntsman Cancer Hospital consent to donate tissue and blood for research purposes The Biorepositoryrsquos IRB

protocol is linked to several clinical and research databases at the U of U including the Data Warehouse the Tumor Registry and the Utah Population Database Thus the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures The Research Histology Section performs all manner of routine and specialized histology services including processing

20

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

embedding sectioning and staining of formalin-fixed paraffin-embedded (FFPE) specimens and Tissue Microarray (TMA) construction The Molecular Diagnostics Section works closely with the Biorepository and Research Histology Sections to quickly obtain specimens from patients consented on clinical trials This enables researchers to integrate real-time molecular testing into clinical trial protocols helping to bring new research discoveries to patients Currently the Molecular Diagnostics laboratory offers a variety of services including DNA isolation from FFPE specimens SNP Genotyping and Somatic Mutation Profiling with the Sequenom MassArray system for both research and clinical trial specimens

Gulbahce a native of Turkey graduated from Hacettepe University Faculty of Medicine and did her anatomic and clinical pathology residency and surgical pathology fellowship at the University of Minnesota where she stayed as

faculty for fifteen years After spending twenty winters in Minnesota she decided to relocate to the ldquowild westrdquo During her tenure at the University of Minnesota a large center for solid organ and bone marrow transplantation she worked on complications of transplantation and graft versus host disease describing a unique GVHD related pulmonary complication After establishment of a new breast center at the University of Minnesota she became interested in breast pathology At the University of Utah Gulbahce is one of three breast pathologists and she is interested in specific risk factors for triple negativebasal like breast cancer subtype She is also continuing her studies towards masters in clinical investigation which she started in Minnesota

BY EVIN GULBAHCE MD

Additional news - Remodeling the Department With our significant and rapid growth throughout our department we are now busting at the seams As Irsquom sure you have noticed we are currently remodeling our space trying to find room for everyone Having to find a seat for 10 residents 6

fellows and all the faculty and staff is causing us all to shuffle around a little The old Kings Peak Conference room has been converted into a new shared office while the slide room and old shared office will be changed into faculty offices We are excited about

all the changes occurring and look forward to see where the future in our department takes us including hopefully a larger space

BY JUSTIN BOGGS

21

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Incoming Anatomic Pathology Faculty

MAZDAK KHALIGHI MD

Maz grew up thirty minutes outside the great city of Detroit Michigan He graduated from the University of Michigan in Ann Arbor with a degree in Cellular and Molecular Biology and received his MD from Jefferson Medical College in Philadelphia Pennsylvania Maz completed a clinical internship in pediatrics at Stanford University and an anatomic pathology residency at the University of California Los Angeles He most recently completed a fellowship in medical renal pathology at the University of Chicago and a general surgical pathology fellowship at the University of Utah

ANNA MATYNIA MD

A native of Poland Anna received her medical degree from the Jagiellonski University in Poland Before graduating in 2005 she completed part of her training in Rome Italy under a SocratesErasmus Program scholarship After completing a one-year transitional year program in Poland Anna worked at the University of Alabama at Birmingham as a research assistant Anna moved to Utah in 2009 and in 2013 graduated from the University of Utah APCP Residency Program She completed a Hematopathology Fellowship prior to joining the Molecular Genetic Pathology Fellowship both at the University of Utah Anna her husband Dave and their son Max are excited to be in Utah and enjoy the hiking and skiing opportunities of the state

KAJSA AFFOLTER MD

Kajsa graduated from the University of Utahrsquos APCP residency program this June 2015 having served as co-chief resident over the past year While at the University of Utah she also completed a Gastrointestinal and Hepatobiliary Pathology Fellowship She earned an MD from Kansas University School of Medicine in 2010 alongside membership in her institutionrsquos Gold Humanism Honor Society and participating in medical mission trips to South Africa and Ecuador Prior to this she graduated summa cum laude from Kansas State University in 2006 completing a bachelors degree in microbiology and working in a research lab as a Howard Hughes Scholar Kajsa has truly enjoyed her residency and fellowship experience at the

22

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

University of Utah and is excited to begin her new position She and her husband Mike are looking forward to staying in the beautiful state of Utah

ERIC A SWANSON MD

Eric is originally from southern California He studied Chemistry and then worked on the molecular and physiologic basis of cardiovascular disease at the University of California San Diego After deciding to pursue a medical degree he moved east to Chicago graduating from Rush University His pathology residency was completed at the University of California Los Angeles He then stayed on there to train in the Klaus Lewin GastrointestinalLiver Pathology Fellowship Eric his wife Shannon and daughter Maren are looking forward to moving to Salt Lake City and exploring the city and surrounding areas

Incoming Anatomic Pathology Fellows

SAM R PAGE MD - GI PATHOLOGY

As a Salt Lake City native native Sam bleeds Ute Red He received his undergrad in Biology from the University of Utah received a masterrsquos in Medical Lab Science from the U graduated from the Ursquos med school in 2011 and just successfully finished up his APCP residency here with us He also has ten years of ARUP laboratory experience under his belt seven of which involved DNA sequencing research and development Sam enjoys skiing mountain biking and camping with his familymdashitrsquos no wonder he feels at home in Utah

SHULING ZHENG MD PHD ndash SURGICAL PATHOLOGY

(Photo unavailable) Shuling comes to us from SUNY at Stony Brook University Hospital NY where she completed her APCP residency She graduated from Qingdao University Medical College in China and continued her education with a Masters of Medicine in Molecular Immunology from Peking Union Medical College in Beijing as well as a PhD in Molecular Genetics from the

23

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

University of Texas-MD Anderson Cancer Center Shuling looks forward to her time in Utah and we warmly welcome her

13 MICHAEL PROCHASKA MD ndash SURGICAL PATHOLOGY

Michael is a University of Kansas School of Medicine graduate who first received his Bachelors of Science in Cellular Biology at the University of Kansas He just recently completed his APCP residency at Drexel University College of Medicine in Philadelphia working in the Hahnemann University Hospital Michael likes to get outside and be active by running skiing hiking and golfing He loves trying foods from different parts of the world and will try ANYTHING at least once Some of the more interesting foods hersquos tried include Fugu (blowfish from Japan potentially lethal if not prepared appropriately) and Balut (a boiled fertilized duck egg popular in the Philippines)

REBECCA ALLRED MD - CYTOPATHOLOGY

Rebecca is an accidental achiever extraordinaire She received undergraduate degrees in Microbiology and Psychology from the University of Idaho and spent two years as a behavioral therapist before attending medical school at the University of Washington as part of the WWAMI program Since coming to Salt Lake she has completed an APCP residency a GI fellowship and will begin a Cytopathology fellowship in July When she isnt working Rebecca is writing Her fiction has appeared in collections both online and in print

GONZALO BARRAZA MD - CYTOPATHOLOGY

Gonzalo received his undergrad in Biological Chemistry from the University of Texas at Arlington and graduated from medical school at UT Southwestern Medical Center in Dallas in 2010 He finished his APCP residency at the University of Utah in 2014 He just completed a Surgical Pathology Fellowship with us and will be a Cytopathology Fellow this year Gonzalo enjoys snowboarding and rock climbing and hiking during the sad times of the year when there is no snow

24

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Pediatric Pathology

Faculty Spotlight Lance Erickson PA (ASCP) MB HTL Lance Erickson PA (ASCP) MB HTL has been working at Primary Childrenrsquos Hospital (PCH) for 15 years He is the Anatomic Pathology Supervisor in Pediatric Pathology at PCH where he manages the areas of Histology Gross Room and Technical Autopsy He is an adjunct faculty member in the Department of Pathology He has ASCP certifications as a Pathologists Assistant Technologist in Molecular Biology and Histotechnologist

Lance received his Masters of Science while working at PCH His degree was awarded through the Pathology Departments program in Laboratory Medicine and Biomedical Science Drs Opitz Pysher and Lowichik sat on his committee and collaborated with him on his thesis entitled ldquoPosterior Homeotic Transformation of the Cervical-Thoracic Border is a Marker of Maldevelopment in Humansrdquo He focused on observations identified over many years in the pediatric autopsy service of a seemingly high incidence

of cervical ribs in these cases Cervical ribs are present in about 04 of adults and the thesis series from PCH patients showed that close to 50 of stillborn patients have cervical ribs This posterior homeotic transformation or change in the identity of the seventh cervical vertebral body into the identity of a thoracic vertebral body bearing ribs has implications with early developmental programs and HOX genes Changes to the identity of vertebral bodies in this area appear as a marker of disadvantageous development and is associated with stillbirth congenital malformations and aneuploidy He is inspired by his University experience and many mentors who assist with the surgical and autopsy programs at Primary Childrens This experience highlights the opportunity to collaborate with faculty in the

Division of Pediatric Pathology and the Department of Genetics

Mr Erickson teaches courses in human development and evolution and mentors Genetic Counseling students He enjoys teaching opportunities with the Medical Students in laboratory education with labs in Perinatal PathologyPlacenta and Congenital Heart Disease Other teaching opportunities that Lance provides are in gross placenta pediatric surgical gross pathology pediatric technical autopsy cardiac development

25

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

congenital heart disease and histotechnique directed to diverse groups including Technical Anatomic Pathology staff at PCH Pathology Residents Cardiology Fellows Echocardiographers and Maternal Fetal Medicine Fellows

Lance is involved on the national level with the American Association of Pathologists Assistants and the National Society for Histotechnology He has presented at many national

meetings He works on the pediatric section of the Grossing Guidelines that are part of a collaboration with the CAP (College of American Pathologists) and the AJCC (American Joint Committee on Cancer) as a group of documents for gross room instructions and guidelines for specific tumor and specimen types The project is in development stages but will prove to be the source of expert and complete gross room dissection and instruction

Lances expertise and most enjoyable part of his job involves congenital cardiac morphology He has a unique teaching and development opportunity at Primary Childrens with direct access to a collection of explanted and autopsied hearts with congenital heart disease The hearts are used for many types of education The added benefit of seeing touching and manipulating the actual hearts of patients is a highlight for all levels of experience and education The collection has been used

26

Photo (above) Halloween with Histology staff at PCH (from left to right) Allyson Christensen Matthew Lemaistre Ysabel Escalante-Chavez Lance Erickson

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

as the basis of many publications and continues to be a valued resource There is usually not opportunity for direct interaction with patients as part of the service in Pathology Lance has this unique opportunity when pediatric patients have special requests to see and hold their own specimens from surgical explant procedures He gets to spend a brief moment with them and family members to demonstrate the gross pathology of their specimens

Noteworthy Progress Lance Erickson amp Michelle Wilkinson are in the early curriculum and planning stages for a proposal to start a

Pathologists Assistant program through the Department of Pathology Currently there is only one program west of the Mississippi for training of Pathologists Assistants They believe the atmosphere location and support is ideal for the University of Utah and the Department of Pathology to start a program for this training This would mean an additional graduate program through the Department of Pathology and the opportunity to educate and fill the needs of pathology groups in the western half of the United States that are constantly in need of well-

trained and educated gross room personnel

Mr Erickson resides on his mini-homestead in Layton with his wife two children chickens goats horses dogshellip and soon a couple of pigs He enjoys the outdoors and would rather be found somewhere high in the mountains hiking and camping When it all becomes too much you can find him on the open road feeling the wind on his face riding his Harley-Davidson into the sunset

BY LANCE ERICKSON PA (ASCP) MB HTL

Incoming Pediatric Pathology Fellow PETER A ABASOLO MD

Peter was born and raised in the Chicagoland area He graduated from the University of Illinois at Urbana-Champaign with a BS in Molecular and Cellular Biology Peter earned his MD at the Loma Linda University School of Medicine in Loma Linda California He then completed his APCP residency training at Harbor-UCLA Medical Center in Torrance California Peterrsquos main professional interest is in cytopathology and he just completed a Cytopathology Fellowship at the University of Utah His hobbies include running listening to and playing music and Chicago sports

27

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Administration Administrative Team Building Week BY ERIN BAKE BS NBA

In April 2015 the Pathology Administration team celebrated their first annual Administrative Team Building Week The goal of this event was to increase awareness of the value that our administrative professionals bring to the department and improve employee engagement and morale The week was filled with short events that brought the team

together It began with a Kick-off brunch on Monday morning where we introduced the events of the week ate some tasty food and took our First Annual Pathology Administrative Team Photo The weekly games consisted of a parent picture game and a candy jar guess game Admins submitted photos of their parents at any stage of adult

life and we all spent the week guessing which photo belonged with which admin Tuesday Wednesday and Thursday we played Minute-to-Win-it games and ate snacks Tuesday we played ldquoBack Fliprdquo flipping pencils off the back of our hand adding 2 each time to see how many we could flip and catch in one minute Wednesday was ldquoStack

28

Photo (left to right) Becky Johnson Sarah Barth AJ Boldan Lydia Lefler Jessica Groves Erica Jessop Erin Bake Allison Boyer Lisa Peterson Justin Boggs Marsha Williams Andrea Bake Doris Warner Shannon Ritzman Connie Walters Krista Spilker LJ Johnson Jenny Johnson

Andrew Saunders Kim Antry Dan Hutton William Lowder

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Attackrdquo where we had to see how fast we could stack 36 Red Solo cups from a single stack to a pyramid and then back to a single stack On

Thursday we played ldquoSeparation Anxietyrdquo by taking 60

seconds see how many mini MampMrsquos we could separate into individual cups by color All of these games were extremely fun and everyone had a wonderful time Friday was our Appreciation Lunch with lasagna Alfredo salad and breadsticks from Olive Garden We had a slide show with the Parent Photo Answers and

announcements

of the Game Winners and awarding of prizes Justin Boggs won Back Flip with 24 pencils

Erin Bake was able to stack and un-stack the cups in 378 seconds Erica won separation anxiety by separating 80 mini MampMrsquos in 60 seconds

Lisa Peterson blew us all away with 1621 correct guesses on the Parent Photo Game and Jenny Johnson came within 250 of the correct guess of 2526 mini MampMrsquos in a Jar

29

Photo (above) Marsha Williams

competing in ldquoStack Attackrdquo

Photo (left) Lydia

Lefler Becky Johnson

Lisa Peterson Jessica

Groves Sarah Barth

Will Lowder Andrew

Saunders Krista Spilker waiting to

compete

Photo (above) LJ Johnson trying his luck with ldquoBack Fliprdquo

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Prizes consisted of a fleece throw mugs water bottles paper and pen items a variety of bags and other various items Our Admins also

received a copy of our admin photo All in all everyone had a really great week and were sad that it had to end We hope to continue the annual

Administrative Team Building Week and Admin Team Photo (above)

Realigning Faculty Support BY SARAH BARTH We took a step back to look at the administrative structure of Pathology as a whole It came as no surprise that we identified areas that are running a little more smoothly or efficiently The most notable difference in these areas is a more defined one-to-one relationship between faculty and their admin support This relationship and the trust it develops is worth pursuing in all areas of Pathology So in an attempt to better align administrative staff with the faculty they support and create the type of one-to-one relationship wersquod like to see more of wersquove concocted a Responsibility Matrix assigning each faculty member a direct line of support on the University side and on the ARUP side A set of guidelines has been distributed to the administrative staff to accompany this matrix These guidelines include responsibilities such as

bull13 The University employee listed in this column is tasked to be the primary administrative support for all things related to the Department of Pathology and all other University of Utah business

bull13 The University admin should communicate regularly with their faculty member(s) in order to ensure proper

communication channels are in place and expectations are met

bull13 The University admin is the primary gatekeeper for their faculty needs This does not overlook the fact that we are a team and should rely on each otherrsquos knowledge and expertise to support faculty in the best way possible Whenever appropriate staff members should work on problems together to get work done more efficiently If work needs to be parsed or delegated the primary admin is still responsible to coordinate all aspects keeping the end product seamless for their faculty member

The guidelines also address the responsibilities between the ARUP and University administrative staff encouraging a similar one-to-one relationship between the two locations and greater communication amongst other things To see the full set of guidelines as well as the matrix visit smbfileserver4pathutaheduPath_AdministrationFaculty

We all need to readjust to this new way of doing things It will take ndashthe dreaded wordmdashchange which is always rocky but worthwhile if it makes things better And thatrsquos what this is about making things better

30

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31

JULY 1 2015 VOL2 ISSUE 1

Information Technology

Logout vs Restart vs Shut Down BY PATH IT (DAN HUTTEN KIM ANTRY AJ BOLDAN LJ JOHNSON) You may have heard us say that to a workstation (computer) ldquoa Logout is like a power nap and a Restart is like giving it a good nights sleeprdquo

Logging out of your workstation nightly has many benefits some of which are

- Secures your data - Allows Managed Software Updates to run

(Macs) - Ensures documents are saved - Safely disconnects you from the server so

that maintenance can take place as scheduled

ldquoWhy does Path-IT ask me to Restart my workstation when I report a problemrdquo

- Restarting allows the workstation to bull Flush RAM bull Stop Memory Leaks bull Delete Temporary Files bull Perform Diagnostics and System

Checks

Why does Path-IT ask me not to Shut Down my workstationrdquo

- Many maintenance tasks such as minor updates and Anti-Virus scans are scheduled to run during non business hours We need the computers on and at the login window for this to take place

Why does Path-IT request that you forward a phishing or scam email as an attachment By forwarding as an attachment you allow University Security teams to securely analyze your email and view information pertaining to the flow of email (headers) Instructions for How to Forward as an Attachment can be found here httptinyurlcomfwdattach

Will you be traveling soon Please contact Path-IT or review our pre travel recommendations This is especially important for portable workstations (laptops) Topics include confirming your data has been backed up verifying accounts and remote access httptinyurlcomtravelingsoon

As you may have heard Path-IT is restructuring to better meet the current IT Support needs of our customers The position formerly held by Joel Taylor will become a dedicated ldquoTier 1rdquo position focusing on Incident Response and Help Desk operations The position formerly held by Andrew Saunders will remain as an ldquoIT Specialistrdquo

Path-ITrsquos hours of operation are 800am to 500pm The preferred method to contact us is via email path-itlistsutahedu Alternatively you can call us at 801-585-0961

31