Dr. Peter J.E. Verdegem Chief Scientific Officer
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Transcript of Dr. Peter J.E. Verdegem Chief Scientific Officer
Dr. Peter J.E. VerdegemChief Scientific Officer
VisuTein: A powerful protection for age-related eye disorders
The human eye: anatomyThe human eye: anatomy
CataractCataract
Scene with normal vision Scene with cataract vision
Pictures: NEI
GlaucomaGlaucoma
Scene with normal vision Scene with glaucoma vision
Pictures: NEI
Age-related Macula DegenerationAge-related Macula Degeneration
Scene with normal vision Scene with AMD vision
Pictures: NEI
AMD & Amsler gridAMD & Amsler grid
Normal AMD
Eye diseases: current treatmentsEye diseases: current treatments
• Cataract– Lens extraction
• AMD– Laser surgery
• Glaucoma– Drug therapy– Laser surgery– Conventional surgery
• Cataract– Lens extraction
• AMD– Laser surgery
• Glaucoma– Drug therapy– Laser surgery– Conventional surgery
Prevention
Cataracts: biological backgroundCataracts: biological background
DisfunctionalProteases
Accumulation of damaged proteins
Cataract
ProteasesRemoval damaged proteins
ProteinOxidizedProteins
Sun light OH•
O2•– H2O2
GSH peroxidase
CatalaseSOD
Beta-carotene Vitamin E, C
Module 1Module 1 I
Vitamin C
Vitamin E
Beta carotene
Directantioxidants
0
0,2
0,4
0,6
0,8
1
1,2
1,4
1,6
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Multivitamins Vitamin C Vitamin E
Jacques, PF; Int. J. Vitam. Nutr. Res. 1999; 69:198.
Antioxidants: Studies for Cataract
Module 1Module 1 I
Vitamin C
Vitamin E
Mixed carotenoids
Selenium
Zinc
Copper
Vitamin B6
N-acetyl-L-cystein
Directantioxidants
Co-factors forenzymaticantioxidantdefence
Glutathionsynthesisstimulation
Herbal antioxidantsource
Vaccinium myrtillus
Herbal antioxidantsHerbal antioxidants
•Rich in anthocyanosides•Stimulant of visual acuity
Morazzoni, P et al; Fitoterapia 1999; 67:3.
Module 2Module 2 I
Vitamin A
Beta carotene
Important nutrients
Module 3Module 3
Lutein
Zeaxanthin
III
Macula pigments
Macular pigment: lutein and zeaxanthinMacular pigment: lutein and zeaxanthin
Zeaxanthin
Lutein
Function•Structural•UV-protection
Source•Dark green leafy
vegetables
-4
-2
0
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10
12
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-15 -10 -5 0 5 10 15
0
0,5
1
1,5
2
2,5
Dist from centre (mm)
Macular pigment: lutein and zeaxanthinMacular pigment: lutein and zeaxanthin
Lutein
Zeaxanthin
Landrum; Arch. Bioch. Biophys. (2001); 385:28.
Lutein supplementationLutein supplementation
Landrum, J et al; Am. J. Clin. Nutr. 2000; 72:844.
Clinical Study with VisuTEINClinical Study with VisuTEIN
• Louisiana Retinal Institute• Dry AMD patients• Study versus OcuVite• Improvements
– Recovery from a flash– Contrast sensitivity– Visual Acuity
• Louisiana Retinal Institute• Dry AMD patients• Study versus OcuVite• Improvements
– Recovery from a flash– Contrast sensitivity– Visual Acuity
Dr. Peter J.E. VerdegemChief Scientific Officer