Slide 1

Dr Kamini A Rao

Slide 2

Over 100 000 individuals under 45 years are diagnosed of cancer annually in US. Improved treatment and survival Fertility preservation is a quality-of-life issue.

Slide 3

Factors contributing to ovarian failure: Age at time of treatment Drug type Cumulative dose Cyclophosphamide: Most gonado-toxic Cumulative dose strongly influences POF rate Pelvic or total body irradiation also has high risk of POF

Slide 4

No ideal marker FSH AMH ovarian volume AFC similar to controls Transient suppression of inhibin B in pre-pubertal girls.

Slide 5

1. Young cancer patients 2. Childhood pelvic tumours: Ewings sarcoma, osteosarcoma, retroperitoneal sarcoma, anorectal cancer 3. Wilms tumour, neuroblastoma, rhabdomyosarcoma 4. Autoimmune disorders SLE, Behcets disease, steroid resistant glomerulonephritis 5. Chemotherapy for bone marrow transplantation and stem cell transplantation

Slide 6

15% of all breast cancer cases are estimated to occur in women