Dr. Abad Ali Assistant Professor (Organic Chemistry)

Organic Chemistry Division Department of Chemistry Aligarh Muslim University, Aligarh, (UP), India 202002. Email Id: abadchem12@gmail.com; abadali.rs@amu.ac.in Mob. No: +91-9456063243

Educational Qualifications: 2017-2018 National Post-Doctoral Fellow (NPDF) at OCD, CSIR-NCL, Pune. 2012-2016 Ph.D. in Organic Chemistry from A.M.U., Aligarh. 2009-2011 M.Sc. in Organic Chemistry with First division from A.M.U., Aligarh. 2006-2009 B.Sc. (Hons.) in Chemistry with First division from A.M.U., Aligarh. 2004 Intermediate with First division from A.M.U., Aligarh. 2002 High School with First division from A.M.U., Aligarh.

Achievements & Awards: NPDF (National Post-Doctoral Fellowship) awarded by SERB, New Delhi, 2017. Academic reviewer of Journal of Molecular Nanotechnology and Nanomedicine (JMNN),

Elyns Publishing Group, USA.

Research & Teaching Experience: 2017-2018 National Post-Doctoral Fellow (NPDF) at Organic Chemistry Division

(OCD), CSIR-National Chemical Laboratory (NCL), Dr. Homi Bhabha Road, Pashan, Pune (MH) – 411008. Title: “Privileged non-symmetrically modified pincer ligand platform: syntheses, mechanistic insight and kinetic control of pincer complexes for cross-coupling reaction of indole-based compounds (IBCs)” Advisor: Dr. Benudhar Punji Principal Scientist (CSIR-NCL) & Associate Professor (AcSIR)

2018-Continue Assistant Professor (on contractual basis), Department of Chemistry, Faculty of Science, A.M.U., Aligarh. Courses taught: B.Sc. 1st semester – General Chemistry (Organic Chemistry Part) – CHB 151 B.Sc. 3rd semester – Organic Chemistry-I – CHB 352 B.Sc. 4th semester – Organic Chemistry – CHB 453

Summary of Ph.D. work:

Title of Thesis: “Synthesis, Characterization and Biological Evaluation of Steroidal Heterocyclic Compounds”.

Mentor: Prof. Shamsuzzaman

Significant Outcomes: Steroidal compounds have drawn attention not only due to unusual and interesting chemical structures, but also due to their widespread application as anti-inflammatory, diuretic, anabolic, contraceptive, antiandrogenic, progestational and anticancer agents. In the global drug market, steroid drugs rank second only after antibiotics. Most steroidal drugs in use today are semi-synthetic compounds and widely used in traditional medicines by the modification of the steroid ring system and side chains. Steroids regulate a wide variety of physiological and developmental processes in vertebrates and are used as the building block in the construction of larger molecules with sufficient rigidity and with suitable substitution for the further modifying of their molecular properties. The major advantage of steroids is their rigid skeleton, variability of substitution and their similarity to naturally occurring structures. The synthesis and physiological activity of hetero-steroids have received a lot of attention over the decades by medicinal chemists. During my Ph.D., I synthesized number of organic compounds based on bio-active pharmacophores. My research work led to the synthesis of novel steroidal compounds substituted by heterocyclic moieties, Oxazoles, Thiazoles, Imidazoles, Pyrimidines, Spirothiazolidinones, Spiroazetidinones and Tetrazoles. The synthesis of novel benzodiazepines derivatives was accomplished using graphene and silica based nanocomposites. The heterogeneous catalysts used to accomplish these organic transformations are ZnO nanoparticles, graphene-mesoporous anatase TiO2 nanocomposite and silica supported on NiO. All these catalysts were designed in the lab and were fully characterized by suitable techniques like XRD, SEM-TEM, IR, TGA etc.

Current Research Interests: My current research interest mainly focused in the direction to address unresolved fundamental questions concerning the activation and functionalization in heterogeneous catalysis of challenging, inherently unreactive C-H bond for cross-coupling reaction of biologically important molecules (like benzimidazole, benzothiazole, benzoxazole, benzopyranone, benzothiophene etc.) by reactive ligands in combination with transition metals (like Pd, Pt, Ru and Rh). Activation and subsequent functionalizations of C‒H bond are the green and sustainable approach for the generation of novel carbon-functionalities.

Research Specialization: Organic Synthesis Medicinal Chemistry Organometallic Chemistry Pincer Ligand Complexes C-H activation Catalysis Heterocyclic Chemistry Steroidal Chemistry Nanotechnology/Nanomaterials

Experimental Skills: Expert in the interpretation of FT-IR, 1H, 2D COSY, NOESY NMR, 13C NMR spectra, DEPT, GC-

MS, TG-DTA, DSC, SEM, TEM, HR-TEM and Mass spectroscopy. Experience in handling light and moisture sensitive compounds and performing reactions

under inert atmosphere and their proper purification by various techniques. I can handle and maintain many sophisticated instruments which are used in research field for

the characterization of synthesized compounds, bioactive compounds and nanomaterial’s.

FTIR UV-Vis spectrometer CD spectrometer Fluorescence spectrometer Viscometer

TGA-DSC GC-Column GC-MS

A good knowledge of handling various software’s used in research field.

Powder XRD Origin 6.0, 8.1, 9.0 Chem Office 12.0, 13.0, 17.0

Mercury Hex 8.0 docking software Edraw Max 7.9 ChemSketch SigmaPlot 12.0 Microsoft Office 2007, 2010, 2013, 2016

ACD NMR Software Mnova

List of Publications:

2018

1. “Steroidal thiazolidinone derivatives: Design, synthesis and their molecular interaction with human serum albumin” Anam Ansari, Abad Ali, Mohd Asif, Shamsuzzaman Steroids, 2019, 148, 99-113, DOI: 10.1016/j.steroids.2019.02.015.

2. “Discovery of a novel oxadiazine derivative of glucocorticoids endowed with DNA binding activities and molecular docking studies” Sultanat, Abad Ali, Mohd Asif, Asim Rizvi, Mohd Farhan, Shamsuz Zamana J. Taibah Univ. Sci., 2019, 13, 536-546, DOI: 10.1080/16583655.2019.1603575.

3. “Facile one-pot multicomponent synthesis and molecular docking studies of steroidal oxazole/thiazole derivatives with effective antimicrobial, antibiofilm and hemolytic properties”. Anam Ansari, Abad Ali, Mohd Asif, Mohd Ahmar Rauf, Mohammad Owais, Shamsuzzaman Steroids, 2018, 134, 22-36, DOI: 10.1016/j.steroids.2018.04.003.

4. “Microwave-assisted MgO NP catalyzed one-pot multicomponent synthesis of polysubstituted steroidal pyridines”. Anam Ansari, Abad Ali, Mohd Asif, Shamsuzzaman New J. Chem., 2018, 42, 184-197, DOI: 10.1039/C7NJ03742B.

5. “Graphene-mesoporous anatase TiO2 nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one-pot multicomponent synthesis of benzodiazepine derivatives”. Mohd Shoeb, Mohammad Mobin, Abad Ali, Shamsuzzaman, Alim Naqvi Appl. Organomet. Chem., 2018, 32:e3961, 1-18, DOI: 10.1002/aoc.3961.

2017

6. “DFT/B3LYP calculations, in vitro cytotoxicity and antioxidant activities of steroidal pyrimidines and their interaction with HSA using molecular docking and multispectroscopic techniques”. Abad Ali, Mohd Asif, Parvez Alam, Mohammad Jane Alam, Mohd. Asif Sherwani, Rizwan Hasan Khan, Shabbir Ahmad, Shamsuzzaman Bioorg. Chem., 2017, 73, 83-99, DOI: 10.1016/j.bioorg.2017.06.001.

7. “Silica supported NiO nanocomposite prepared via sol-gel technique and its excellent catalytic performance for one-pot multicomponent synthesis of benzodiazepine derivatives under microwave irradiation”. Zeba Nasir, Abad Ali, Mohammad Shakir, Rizwan Wahab, Shamsuzzaman, Lutfullah New J. Chem., 2017, 41, 5893-5903, DOI: 10.1039/c6nj04013f.

8. “Synthesis and characterization of steroidal heterocyclic compounds, DNA condensation and molecular docking studies and their in vitro anticancer and acetylcholinesterase inhibition activities”. Abad Ali, Mohd Asif, Hena Khanam, Ashraf Mashrai, Mohd Asif Sherwani, Mohammad Owaisb, Shamsuzzaman RSC Adv., 2015, 5, 75964-75984, DOI: 10.1039/c5ra11049a.

9. “Microwave-assisted one pot synthesis, biological evaluation and molecular docking studies of steroidal thiazoles”. Mohd Asif, Abad Ali, Atif Zafar, Mohd Farhan, Hena Khanam, S. M. Hadi, Shamsuzzaman J. Photochem. Photobiol. B, 2017, 166, 104-115, DOI: 10.1016/j.jphotobiol.2016.11.010.

10. “Review: “biologically active pyrazole derivatives”.

Anam Ansari, Abad Ali, Mohd Asif, Shamsuzzaman New J. Chem., 2017, 41, 16-41, DOI: 10.1039/c6nj03181a.

11. “Unravelling the interaction of pirenzepine, a gastrointestinal disorder drug, with Calf thymus DNA: An in vitro and molecular modelling study”. Yusra Rahman, Shumaila Afrin, Mohammed Amir Husain, Tarique Sarwar, Abad Ali, Shamsuzzaman, Mohammad Tabish Arch. Biochem. Biophys., 2017, 625-626, 1-12, DOI: 10.1016/j.abb.2017.05.014.

12. “Molecular spectroscopic and thermodynamic studies on the interaction of anti-platelet drug ticlopidine with calf thymus DNA”. Shumaila Afrin, Yusra Rahman, Tarique Sarwar, Mohammed Amir Husain, Abad Ali, Shamsuzzaman, Mohammad Tabish Spectrochim. Acta Mol. Biomol. Spectrosc., 2017, 186, 66-75, DOI: 10.1016/j.saa.2017.05.073.

13. “Synthesis, crystal structure, Hirshfeld surfaces, thermal, mechanical and dielectrical properties of cholest-5-ene”. Shamsuzzaman, Hena Khanam, Ashraf Mashrai, Mohd Asif, Abad Ali, Assem Barakat, Yahia N. Mabkhot J. Taibah Univ. Sci., 2017, 11, 141-150, DOI: 10.1016/j.jtusci.2016.01.001.

14. “Aloe emodin, an anthroquinone from Aloe vera acts as an anti aggregatory agent to the thermally aggregated hemoglobin”. Mohammad Furkan, Md Tauqir Alam, Asim Rizvi, Kashan Khan, Abad Ali, Shamsuzzaman, Aabgeena Naeem Spectrochim. Acta Mol. Biomol. Spectrosc., 2017, 179, 188-193, DOI: 10.1016/j.saa.2017.02.014.

2016 15. “Neurodegenerative diseases linked to misfolded proteins and their

therapeutic approaches: A review”. Hena Khanam, Abad Ali, M. Asif, Shamsuzzaman Eur. J. Med. Chem., 2016, 124, 1121-1141, DOI: 10.1016/j.ejmech.2016.08.006.

2015 16. “Synthesis, characterization, biological evaluation and molecular docking of

steroidal Spirothiazolidinones”. Shamsuzzaman, Khan A.A. Abdul Baqi, Abad Ali, Mohd Asif, Ashraf Mashrai, Hena Khanam, Asif Sherwani, Zahid Yaseen, Mohammad Owais J. Mol. Str., 2015, 1085, 104-114, DOI: 10.1016/j.molstruc.2014.12.036.

17. “Green synthesis and biological evaluation of steroidal 2H-pyrans as anticancer and antioxidant agents”. Shamsuzzaman, Ashraf Mashrai, Hena Khanam, Mohd Asif, Abad Ali, Asif Sherwani, Mohammad Owais JKSU, 2015, 27, 1-6, DOI: 10.1016/j.jksus.2013.10.001.

Book Chapter: “Pyrazole derivatives: Synthesis, reactions and biological

significance”. Anam Ansari, Abad Ali, Shamsuzzaman Lambert academic publishing, ISBN 978-620-2-02116-6.

Conferences / Seminars / Workshop / Symposia Attended and Presented:

Oral Presentation: 1. “Synthesis, characterization and anticancer studies of new steroidal pyrazolines”.

National Seminar on “Plant Sciences: New Technology, Conservation and Environment”, held on February 23-24, 2013, at Department of Botany, A.M.U., Aligarh-202 002, India. Page 61.

Poster Presentation and Abstract: 2. “Green synthesis of ZnO nanoparticles using Bacillus Subtilis and used as catalyst for the

synthesis of steroidal thiophene”. International conference on “Aligarh Nano-V & Stemcon-16”, held on March 12-15, 2016 at Department of Applied Physics, A.M.U., Aligarh-202 002, India. Page 210.

3. “In vitro cytotoxcity and interaction of steroidal spirothiazolidinones with CT-DNA using molecular docking and spectroscopic techniques”. International conference on “Recent Advances in Chemical Sciences”, held on March 29-30, 2016 at Department of Chemistry, A.M.U., Aligarh-202 002, India. Page 151.

4. “Synthesis, characterization of steroidal spirothiazolidinones”.

National Symposium on Chemistry (NSC), held on March 22, 2014 at Department of Chemistry, A.M.U., Aligarh-202 002, India. Page 101.

5. “Design, synthesis, evaluation and docking studies of novel spiroazetidinone substituted steroidal derivatives possessing potent diversified pharmacological properties”. International conference on “Overcoming the Bottlenecks in Drug discovery & Development”, held on 20-21 March 2014 at DSIN-Ranbaxy, Gurgaon, India. Page. P 15.

6. “Novel microbial route to synthesize ZnO nanoparticles using Bacillus subtilis (FJ460362)”. International conference on "Nanoscience and Nanotechnology (Aligarh Nano IV)”, held on March 8-10, 2014 at Centre of Excellence in Material Science (Nanomaterials), Department of Applied Physics, A.M.U., Aligarh-202 002, India. Page. 74.

7. “Synthesis, characterization, biological evaluation and molecular docking of steroidal

spirothiazolidinones”. International conference on "New Horizons in Pharmacy and Pharmocology”, held on 15-16 February 2014 at GLA University, Mathura, India. Page. P 75.

8. “Antimicrobial and antioxidant studies of steroidal thiophene derivatives”.

National Symposium on "Recent advances in free radical biology and biochemistry”, held on March 6, 2014 at Department of Biochemistry, A.M.U., Aligarh-202 002, India. Page 19.

9. “Synthesis, molecular docking, in vitro DNA binding and anticancer activity of new steroidal

1H-pyrimidines”. Current Trends in Drug Discovery Research (CTDDR)-2013 5th International Symposium on “Drug Development for Orphan/Neglected Diseases”, held on February 26-28, 2013 at CSIR-CDRI, Lucknow, India. Page 222.

10. “Molecular docking, in vitro DNA binding and cytotoxicity of newly synthesized steroidal 1H-pyrimidines”. International conference on “Chemistry: Frontiers and Challenges”, held on March 2-3, 2013 at Department of Chemistry, A.M.U., Aligarh-202 002, India. Page 141.

11. “Green synthesis and biological evaluation of steroidal 2H-pyrans as anticancer and antioxidant agents”. National Workshop on “Advances in polymer materials”, held on Septermber 21-22, 2013 at Department of Applied Chemistry, A.M.U., Aligarh-202 002, India. Page 10.

12. “ZnO nanoparticles: An efficient and recyclable nanocatalyst for synthesis of steroidal pyrazolines”. National conference on “Nano science and Nanotechnology (Aligarh Nano III)”, held on March 10-12, 2013 at Department of Applied Physics, A.M.U., Aligarh-202 002, India.

Extra Curriculum Activities: Participation in cultural and literary programs, seminars, lectures, etc. Actively engaged in social works. Surfing internet for scientific knowledge, playing and watching cricket, reading general book for social and completive knowledge. I solemnly declare that, the above statements made by me are correct to the best of my knowledge.

Dr. Abad Ali