December 20, 2012

Evolving Applications that Demonstrate the

Versatility of the NeSSITM Platform

Sampling Platforms for the Field and Laboratory: Value of

the NeSSITM Platform

Analytical Systems: The Big Picture Sample Conditioning

IntraFlow™

Sample Disposal Vent Master™

Sample Extraction

Analyzer

Clean Gas

DBB Probe

Sample Transport Heat Trace

Change Over System

Gas Generators

Process analysis requires efficient

control of temperature, pressure

and flow at all levels of analytical

architecture

Process and Lab Analytical Problems?

80% of all process analyzer failures can be

attributed to a sampling conditioning system

failure – also a failure component in lab analysis

3

Conventional Solution: Highly engineered, complex sampling

systems must be constructed to properly present representative

sample matrix to analytical instrumentation

Modular Sampling Solution: Highly engineered, yet, simpler

sampling systems may be constructed to properly present

representative sample matrix to analytical instrumentation

Efficient Sampling: The Key to

Process and Laboratory Analytics

• What’s in the pipe/column needs to be presented

to an analyzer (high volume to low volume)

4

Process

Laboratory

? Pressure, Flow and Temperature Control

Sample Conditioning Systems:

* Custom designed, engineered and

built

* Lots of tubing/fittings

* Many man-hours

designing/building it

* Lots of discrete components

Cost Issue – Irritates the Bean Counters

* Typically not Smart

(Smart = knowing if p,t,f of sample

are normal, i.e. validating

representative sample)

“Quality of Measurement Issue” -

Credibility of analysis – Lab vs.

Analyzer Engineering

Picture Courtesy

ExxonMobil Chemical

Modular Sampling Systems Based on a Common Standard

Based on ANSI/ISA SP76.00.02

Standard

The standard defines the following

attributes of modular, surface-mount

hardware as the interface of the device

(valve, regulator, sensor or other active

component) with sample fluids. This

standard allows for two basic mechanical

architectures, a 1.5” flow substrate and a

2.25” flow substrate. 6

The New Sampling/Sensor Initiative aims to

make significant improvement to the design and

operation of on-line analyzer systems. The

driving forces behind the initiative are economic:

NeSSI™ will make analyzer systems less

expensive and they will give a better pay back.

NeSSITM

Gen I: Fluid Handling Systems Mostly Mechanical Components

7

Gen II: Electrically Networked

Systems IS Serial Bus, miniTransducers, local wireless

Gen III:

Microanalytical

Systems Platform for microAnalytical, remote

wireless, advanced gas & liquid sensors

NeSSITM – Modular Sampling Systems: Technology Roadmap

8

IntraflowTM Parker Modular (NeSSITM)

Systems: Gen I Foundation of Modular Approach

Slip-fit intra-

fitting connectors

Same screw size

throughout

ISA/ANSI SP76.00.02

Compliant

Mounting

“Pegboard”

Field connectors

(top or end)

Same plane

flowpaths

9

•Design Drivers

• Simplicity Overcomes Limitations

IntraFlow™ Fitting IntraFlow™ System

10

IntraFlow™ Fitting

IntraflowTM Substrates/Flowpath Options: The Library is Has Become Much Larger to Accommodate

Laboratory and Process Applications (over 100 flow options)

Standard of

Flexibility

11

IntraFlow™ Fitting

Eductor

Stream

Selection

Versatility of IntraflowTM

fitting allows multiple

options for flow and

sample conditioning

Conventional Sampling “Tool Box” Available

• Full range of valves (Library)

• Full range of pressure control hardware

• Flow control – Volumetric and Mass

• Flow/Pressure Monitoring (Local/Remote)

• Temperature Control – Convective/Conductive

• Sample Eductors/Pumps

• Sample Cylinders

• Analytical Systems (pH, Cond, O2, GC, RAMAN, FTIR…)

12

Modular Systems: Where and How

are They Used?

• Typical process analyzer sample conditioning

applications – liquids and gases

• Fluidic control for reaction systems

• Mixing/blending of pure gases for supplying

variable concentration ranges

• Platform for supplying controlled sample to on-

board analytical systems – Gen. III

• Implementation of gas purifying hardware

13

Applications of Modular Sampling

Systems – IntraflowTM –Lab and

Process Analyzers

14

>

What Does NeSSI™ Look Like?

Conventional

Modular

Complete Modular Integration

IntraflowTM Process

Sample Conditioning

17

Sample Flow Monitoring

Sample Stream Isolation

Sample Collection

Temperature Control

Sample System Variability Accommodated

18

Stack Gas Monitoring:

• O2 Analyzer

• Eductor

• Flow Monitoring

• Pressure Control/Monitoring

• Sample Stream Selection

• Remote Calibration/Validation

Manual Liquid Sample Control:

• Manual Valve Isolation

• Space Reduction

• Sample Header Implementation

10-Stream Natural Gas BTU

Analysis System

• Coalescing & Membrane

Separator Drain Header

• Restricted Orifice Header

Pressure Control

• Freeze Protection Heating

• Sample pressure 1,500 – 3,000psig

High Pressure Applications

Common Drain

Specifications

• Falcon Microfast GC

• Parker IntraflowTM gas

handling/sampling

system

• Carrier gas

• Mobility

IntraflowTM and Transportable Analytical Applications

The NeSSITM Platform Accommodates Sampling

‘At The Process Extraction Point’

21

Astute System with C2V Micro GC and

H2Scan hydrogen analyzer

Courtesy of E.I.F

(www.eif-filters.com)

microGC H2 Sensor

Reactor Feed 1

Reactor Feed 2

Product Stream

Real-time Calibration

waste

prod

Analyzer Suite

Pump 1

Pump 2

NeSSITM Reactor Sampling/Calibration

• Application of sampling systems and analytics to optimize and control reactor

Micro Reactor Continuous Flow Control

23

Courtesy of Dow Corning

Micro Reactor Control Scheme

24

Micro Reactor Control Platform

25

Micro Reactor Fluid Control with IntraflowTM

26

DoE with NeSSITM

27

One of (4) NeSSI Systems Utilized

NeSSI™ Sampling System for Reactor

Raman Probe

monitor

bypass

clean

NeSSI™ and Raman Probe Reactor Application

Courtesy of Dow Corning

NeSSITM and MicroReactor Performance Analysis

30 U.S. Food and

Drug Administration

0 500 1000 1500 2000 2500 3000 35000

0.2

0.4

0.6

0.8

1

1.2

Raman Shift (cm-1

)

No

rm

alized

In

ten

sit

y (

Arb

. U

nit

s)

Normalized Standard Spectra

Courtesy of Brian Marquardt

Technologies That Will Influence Process

Measurement

31 Quadrapole MS on a Chip

Micro-GC

Complete Systems Package

Over/Under Flow

• Carrier Gas

• Sample Gas

• Pressure Control

• Sample Injection

• GC Analysis

33

Biotechnology Application – Fermenter Off-gas

• Atmospheric Pressure Sample

• Sampling Pump

• Sample Condensation Control

• Automated Stream Selection

Pharmaceutical RAMAN Interface Mount

34

• ½” Probe Interface

• Simple Flow through

• Probe Versatility

• Tubing Accommodated

Small-Scale Fermenter Applications

35

1 Liter Fermentation

Vessel

Pump for liquid

recirculation

Parker IntraflowTM

for Fluidic Control

and Sensor Interface

Dilution/Mixing Systems

Expensive Blended Gas

Cylinder

(H2S, CH4, CO, CO2, etc.)

$$$$

Pure gas cylinders $

Gas Calibration System – Yields

blended gas cylinder results

Lab Process

37

Gas Blending System

• Gas blending

systems enable

users to produce

their own

specialty gas

concentrations.

• Reduces cylinder

use and

increases the

flexibility of

generating

specific blends

on site.

Available with Mass Flow

Control (automated)

Also available with Volumetric

Flow Control (manual)

38

NeSSITM Lab Calibration/Dilution System

• Chlorine-based sample matrix

• Addition of purge without space limitation

• Modular and conventional fitting flexibility

• Surface coating common

NeSSITM Lab Calibration/Dilution System

with On-board Analytics

39

Real-time monitoring of pressure, flow and

component concentration Courtesy of Brian Marquardt – UW APL

IntraFlow™ Vaporizing Regulator

• Easy removal of heat exchanger for exchanger

Patent Pending

IntraFlow™ Vaporizing Regulator

• CFD modeling of the

vaporizer indicates that

room temp water

vaporizes at around

80% through the heat

exchanger

°C

Number of Tetrahedral Elements = .42 million Pressure Inlet: 25 psi Pressure outlet : 5 psi Temperature input to aluminum block: 190 oC All other external walls are considered as adiabatic walls Fluid: Water Solver: Segregated 3D steady solver with SIMPLE pressure-velocity coupling with standard k-e turbulence model.

Location of

Post

Processing

Plane

°C°C

Concept to Functionality: Vaporizer

42 Conceptual Approach

Application

43

Gas-Phase RAMAN Interface

Courtesy of Kaiser Optical Systems

Sample Introduction Flexibility for microAnalytics is Available

44

Inject valves for GC or LC

45

Calibration from NeSSITM -Permeation Tube System

Conceptual Design

Alternative Prototype Testing

Future Modular Sampling Hardware Developments

for the Lab and Process Markets?

• Mixing Systems – Liquid and Gas

Dynamic/Static

• Permeation/Calibration Hardware

• Inject Valve Integration for Microanalytics

• Solvent Delivery System

• Modified Interface Hardware for RAMAN,

FTIR, pH and other probe-based analytics

• Alternative Material Applications - PEEK

46

Acknowledgments

• Brian Marquadt, Charlie Branham, Wes

Thompson, Michael Roberto, Lauren

Hughs and Thomas Dearing– Applied Physics

Laboratory University of Washington

• Kin – Tek Laboratories

• CPAC –University of Washington

47

48

Thank You!!