Seminar Series Week Commencing 14 August 2017

Name of Presenter Title of Presentation Date Time Venue Further Information Seminar Series

Professor Lynn Morris From Bench to Bedside: Developing antibodies for HIV prevention

14 August 2017 12pm – 1pm McCusker Auditorium, Harry Perkins Institute of Medical Research, North Building

CLICK HERE

CLICK HERE

WAHTN Clinical Trials Forum 14 August 2017 5pm – 7pm Seminar Room, Telethon Kids Institute, 100 Roberts Road, Subiaco

http://www.wahtn.org/events/wahtn-clinical-

trials-forum-save-the-date/

Mr Rob Salomon Current trends in Flow Cytometry & Single Cell Transcriptomics

15 August 2017 10.30am – 11.30am Seminar Room 612A Harry Perkins Institute of Medical Research, North Building

CLICK HERE

CLICK HERE CMCA

Prof David A Mackey Born with a Bomb: going blind from Leber hereditary optic neuropathy

15 August 2017 12.30pm – 1.30pm McCusker Auditorium, Harry Perkins Institute of Medical Research, North Building

CLICK HERE

CLICK HERE Health and Medical Sciences: Dean’s Distinguished Lecture Series

Vidya Krishnan Role of nervous system in sarcopenia: Age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

15 August 2017 1pm Room 1.81, Anatomy, Physiology & Human Biology Building North The University of Western Australia (off Hackett Entrance No. 2)

CLICK HERE UWA School of Human Sciences

Download the new WAHTN App! A new way to connect and view upcoming seminars and clinical rounds for science and health across all WAHTN partner institutions.

Name of Presenter Title of Presentation Date Time Venue Further Information Seminar Series

Professor David Newby Molecular & Atomic Imaging In Cardiovascular Disease Chalk & Cheese

16 August 2017 12pm – 1pm RPH - Bruce Hunt Lecture Theatre

CLICK HERE

CLICK HERE 2017 Robert Vandongen Memorial Lecture

Professor Valérie Verhasselt

Impact of mother-child interaction through breast milk on immune development and long term homeostasis

17 August 2017 12pm – 1pm McCusker Auditorium, Harry Perkins Institute of Medical Research, North Building

CLICK HERE

CLICK HERE Perkins

Dr Karen Bell The role of ancient humans in plant dispersal and distributions

18 August 2017 3pm – 4pm Jennifer Arnold Lecture Theatre, Zoology Building, UWA

CLICK HERE School of Biological Sciences

RETP Online Courses Online courses available – Identifying Grant Opportunities: A guide for health researchers – Research Protocol Development – Foundations of Health Research – Critical Appraisal of Scientific Papers – Good Clinical Practice Version 2

CLICK HERE

To enroll go to www.retp.org

UPCOMING SEMINARS

Professor Prue Hart Narrowband UVB phototherapy for early multiple sclerosis: Progress in the PhoCIS trial

25 August 2017 12pm – 1pm Telethon Kids Institute Seminar Room

CLICK HERE Telethon Kids

Professor Leann Tilley Super-resolution and correlative imaging of malaria parasites

30 August 2017 11.15am – 12.15pm McCusker Auditorium, Harry Perkins Institute of Medical Research, North Building

CLICK HERE CMCA

Prof Markus Schlaich The Silent Killer: Keeping Hypertension Under Control

5 September 2017 2pm – 3pm City of Perth Library and History Centre

Click link:

The Silent Killer: Keeping Hypertension

Under Control

UWA Research Week Seminars

Prof Christobel Saunders, Prof Anna Nowak, Prof Bruce Robinson

Advances in Cancer Research

5 September 2017 7pm – 8pm Fox Lecture Theatre (Arts), UWA

Click link:

Advances in Cancer Research

UWA Research Week Seminars

Name of Presenter Title of Presentation Date Time Venue Further Information Seminar Series

Prof Gerald Watts Inherited Risks of an Early Heart Attack

7 September 2017 5.30pm – 6.15pm Bayliss Building Lecture Theatre, UWA

Click link:

Inherited Risks of an Early Heart Attack

UWA Research Week Seminars

Scientist Knowledge Translation Training Workshop 7 & 8 September 2017

9am – 5pm The University Club, UWA $100 per registrant

Click link to register

https://www.trybooking.com/QVMU

Professor Michael Sawyer OAM

Lifting the Lid – Mental Health and Our Kids

13 September 2017 6pm – 9pm University Club, UWA Crawley

www.trybooking.com/291252. OR

https://www.facebook.com/events/182

8048567434636 St John of God Subiaco Health & Medical Research

Week 18–22 September

2017 CLICK HERE St John of God Subiaco CLICK HERE or

www.sjog.org.au/researchweek

Professor Aleksandra Filipovska

Mitochondrial tales of mice and men

20 October 2017 3pm 5th Floor Seminar Room, MRF Building, Rear 50 Murray Street

CLICK HERE RPH Medical Research Forum

School of Medical and Health Sciences, Melanoma Research Group Edith Cowan University

The School of Medical and Health Sciences, Edith Cowan University would like to invite you to the following seminar:

Where: Harry Perkins Institute of Medical Research (McCusker Auditorium) Date: Monday 14th August 2017Time: 12-1pm

For the past 24 years, Professor Lynn Morris has been researching the virological and immunological aspects of South African HIV-1 subtype C infection, making significant contributions to our understanding of how the HIV antibody response develops. HIV vaccine development is now a major focus of her research and she is responsible for performing neutralising antibody assays on human clinical trials conducted in South Africa.

Lynn received her DPhil from the University of Oxford, where after she completed a post-doctoral fellowship at The Walter and Eliza Hall Institute of Medical Research in Australia before returning to South Africa. She has supervised 30 PhD and MSc students and 10 post-doctoral fellows. Lynn has published over 200 papers in peer-reviewed Journals, holding a current author H-Index of 52.

All welcome Please contact Dr. Elin Gray (e.gray@ecu.edu.au) for further information.

Melanoma Research Group Telephone: +61 8 63043640 Fax: +61 8 63042626 Web: www.ecu.edu.au

Prof Morris has received several awards for her contribution to HIV vaccine research, which include the University of the Witwatersrand’s Vice Chancellor Research Award and the South African Medical Research Council’s Gold Merit Award. She is also listed on the Thompsons Reuters 2015 ISIS list of the 3000 highest cited researchers in the world.

"From Bench to Bedside: Developing antibodies for HIV prevention"

Guest Speaker: Professor Lynn Morris Head of the HIV Virology Unit at the National Institute for Communicable Diseases and a Research Professor at the University of the Witwatersrand, in Johannesburg, South Africa.

CMCA Seminar Series Centre for Microscopy, Characterisation and Analysis

CurrenttrendsinFlowCytometry&SingleCellTranscriptomics

Date: Tuesday 15th August 2017

Time: 10.30 am – 11.30 am

Venue: Seminar Room 612a, Harry Perkins Institute of Medical Research.

MrRobSalomon,TechnicalDirector,Garvan-WeizmannCentreforCellularGenomics

MrRobSalomonistheinauguralTechnicalDirectoroftheGarvan-WeizmannCentreforCellular Genomics. His background in biology and engineering ensures that the Centrewillsitcomfortablyattheintersectionofscienceandtechnology.In2014,hewasnamedas a Shared Resource Laboratory Emerging Leader by the International Society for theAdvancementofCytometry.SincethenMrSalomonhasplayedamajorroleinboththeAustralianandInternationalCytometrySocieties.

Mr Salomon is responsible for the technology acquisition and continued technicaldevelopment of the Centre as well as the implementation of its strategic operationalplan.

All Are Welcome

Vidya Krishnan School of Human Sciences The University of Western Australia Role of nervous system in sarcopenia: Age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves Tuesday 15 August, 2017 at 1.00pm

Room 1.81, Anatomy, Physiology & Human Biology Building North The University of Western Australia (off Hackett Entrance No. 2)

The Seminar: Vidya’s PhD research investigated the “Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves”. Sarcopenia, the age-related loss of skeletal muscle mass and function, is of increasing importance as our population rapidly ages and it is essential to understand the molecular and cellular mechanisms leading to sarcopenia in order to develop targeted interventions to maintain healthy ageing. Degeneration of the nervous system is considered a major factor underlying the onset and progression of sarcopenia and substantial reorganization in the neuromuscular system contributes to the loss of motor performance. A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research published as 2 papers in 2016, 2017, provides new insight into the ageing neuromuscular system. This study also provided initial evidence of an age related changes in the spinal cord of the same mice. Collectively, these novel studies suggest that age-related morphological and molecular alterations of the peripheral and central nervous system play a significant role in the onset and progression of sarcopenia. The Speaker: Vidya completed her Master’s degree in Biotechnology at Bharathiar University, India in 2005, and in 2012 started her PhD studies at the University of Western Australia in the School of Anatomy, Physiology and Human Biology, supervised by Professor Miranda D. Grounds, Professor Alan R. Harvey, Assoc/Prof Stuart I. Hodgetts and Assoc/Prof Tea Shavlakazde. Her PhD was awarded in August 2017 and Vidya is now working as a postdoctoral research associate funded by the Neurotrauma Research Program (NRP), UWA on a project to investigate the “Benefits of exercise on age-related changes in old spinal cords.

16 August 2017 12.00 noon – 1.00 pm

Bruce Hunt Lecture Theatre Dial in 6892 - Lunch

2017 Robert Vandongen Memorial Lecture

“MOLECULAR & ATOMIC IMAGING IN CARDIOVASCULAR DISEASE CHALK & CHEESE”

Professor David Newby Director, Edinburgh Clinical Research Facility

University of Edinburgh, Edinburgh UK

In 2017 we will be surveying your feedback for the Hospital Grand Rounds. PGME asks that at the end of each session, could you please take a minute to complete an electronic survey. Please click below for this week’s survey: Atomic In addition we will be listing the survey in our survey channel in #SLACK. This will allow you to complete the survey via your smart phone device immediately after the session. For any queries regarding SLACK or this new method of feedback, please contact the PGME office

Chair: Professor Carl Schultz

2017 Hospital Grand Round

Professor Valérie Verhasselt has been holding the Larsson-Rosenquist

Chair in Human Lactology at the University of Western Australia, School of

Molecular Science, since August 2017. Her translational research is aimed

at understanding how maternal milk impacts on immune development, education and long term

homeostasis. A major objective guiding her work is the identification of factors which could endow

breastfeeding with the capacity to prevent allergic and metabolic disease as potently as it does for infectious

disease.

Valérie Verhasselt trained at the University of Medicine of Brussels (ULB, Belgium) where she obtained the

diploma of Medical Doctor (1992), Specialist in Internal Medicine (2000) and a PhD in Immunology (1999).

In 2004, she moved to France (Université de Nice Sophia-Antipolis) and developed the concept of

breastfeeding induced tolerance for prevention of allergy. She obtained a tenured researcher position at

INSERM in 2008 and created Immune Tolerance team in 2012 in Nice (France). In 2017, she was granted the

first Chair in Human Lactology at UWA. Her research has been published in prestigious reviews such as

Nature Medicine, Gut, Journal of Allergy and Clinical Immunology, Lancet Infectious Disease. The French

Académie Nationale de Médecine (2012) and Académie des Sciences (2008) have acknowledged her major

contribution in the field of prevention of allergy through maternal milk.

12:00pm till 1:00pm followed by a light lunch

For more information please contact Louise Winteringham E: louise.winteringham@perkins.uwa.edu.au

McCUSKER AUDITORIUM, HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH, NORTH CAMPUS

Professor Valérie Verhasselt

Larsson Rosenquist Foundation, Chair in Human Lactology School of Molecular Sciences University of Western Australia

"Impact of mother-child interaction through breast milk on immune development and long term homeostasis"

THURSDAY 17 AUGUST

Karen Bell The University of Western Australia, CSIRO Land and Water, CSIRO Health and Biosecurity

The role of ancient humans in plant dispersal and distributions

The movement of species outside their native ranges is a significant form of anthropogenic impact on the environment. This is commonly considered a relatively recent impact of colonialism and globalism. However, humans have been transporting species around the world for a variety of practical and cultural uses for millennia. In places such as Australia, where there is a long-held view of a continent of hunter-gatherers, with anthropogenic agency limited to ‘fire-stick farming’ of landscapes for nomadic foraging and hunting, the role of indigenous people in the dispersal and distribution of species has mostly been ignored. To understand these ancient human-mediated dispersals requires an interdisciplinary approach, combining data from the biological sciences and the social sciences. There is a small, but growing, body of literature using this interdisciplinary approach to investigate the ancient human history behind the current geographic distributions of various plant species. Using examples from my research, I will present evidence for the role of humans in shaping plant evolution, and determining whether the geographic distribution of genetic diversity is explained, in part, by patterns of human migration. I will also outline where this evidence is lacking, and what sources of data may help to test hypotheses of ancient human-mediated dispersal. Finally, I will discuss the implications for management of native and introduced species in contemporary environments.

School of Biological Sciences

SEMINAR SERIES

When 3 – 4 pm

Friday 18 Aug 2017  

Where Jennifer Arnold LT Zoology  Building,  UWA

Followed  by  beer  club  in  front  of  the  

Botany  Building  from  4pm.   Everyone  is  welcome.

About the speaker

Seminar Coordinators: Clelia Gasparini (clelia.gasparini@uwa.edu.au) and

Alison O’Donnell (alison.odonnell@uwa.edu.au)

Karen Bell is a Lecturer in the School of Biological Sciences at the University of

Western Australia, and a joint appointment with CSIRO. Her research

uses methods from population genetics, phylogeography, evolutionary biology and interdisciplinary collaboration to

investigate questions in invasion biology, plant-human interactions and

plant-animal interactions.

COURSES AVAILABLE

Online courses currently available are:

Good Clinical Practice Version 2 *TransCelerate approved

Module 1 - GCP Origins and Principles

Module 2 - Researchers Responsibilities and Essential Documents.

Module 3 – Informed Consent

Module 4 – Safety Reporting

Module 5 - Source Data and Data Management

*meets the minimum criteria for ICH E6 (R2) GCP Investigator Site Personnel Training

Identifying Grant Opportunities: A guide for health researchers

Research Protocol Development

Foundations of Health Research

Critical Appraisal of Scientific Papers

To self-enrol in a course and receive a certificate of completion go to RETP website.

Enrol here

Follow us on Twitter “@RETP_WAHTN”

RETP website: https://www.retp.org/

“Narrowband UVB phototherapy for early multiple sclerosis: Progress in the PhoCIS trial”

Prue runs an NHMRC-funded trial of UVB phototherapy for people withtheir first demyelinating disease, an early form of multiple sclerosis.

This trial follows 20 years of basic research investigating the mechanismsby which UV radiation is immunomodulatory, independent of anyactions of vitamin D. Prue leads a complementary research programmestudying the effects of UV radiation on myeloid progenitor cells in thebone marrow.

Professor Prue HartHead, InflammationTelethon Kids Institute and UWA

CMCA Seminar Centre for Microscopy, Characterisation and Analysis

Wednesday 30th August 2017 11.15am – 12.15 pm

McCusker Auditorium, Harry Perkins Institute of Medical Research

“Super-resolution and correlative imaging of malaria parasites” Professor Leann Tilley is the Redmond Barry Distinguished Professor at The University of Melbourne, Australia.

Professor Tilley studied at Melbourne and Sydney Universities, and undertook postdoctoral fellowships at Utrecht University (the Netherlands) and the College de France (Paris), before beginning her independent career. In 2015, she was awarded the Georgina Sweet Australian Laureate Fellowship from the Australian Research Council, recognising her research on malaria pathogenesis and drug resistance. She was awarded the Bancroft-Mackerras Medal from the Australian Society for Parasitology

(2010), the Beckman Coulter Discovery Award of the Australian Society for Biochemistry and Molecular Biology (2011) and the Eureka Prize for Infectious Diseases Research (2016). She is President of the Australian Society for Biochemistry and Molecular Biology

New microscopy techniques are providing amazing views of the cellular landscape. We have used 3D Structured Illumination Microscopy (SIM), direct Stochastic Optical Reconstruction Microscopy (dSTORM), 3D-Electron Tomography and Block-Face Scanning EM to explore the sub-cellular topography of the malaria parasite, Plasmodium falciparum. P. falciparum is the most virulent of malaria parasites, causing ~480,000 deaths per year. Efforts tocontrol malaria need to target both asexual multiplication in red blood cells (RBCs), which causesdisease, and sexual development, which is responsible for transmission.We have probed the changes to the host RBC membrane skeleton that mediate rigidity changes andimaged the virulence complex that the parasite establishes at the RBC surface, which mediatesadhesion to blood vessel walls. We have explored the changes in the parasite and host cytoskeletalstructures that underpin the remarkable reversible morphology changes that permit sexual bloodstages to survive in the circulation ready for transfer to the mosquito vector.Leann Tilley1, Boyin Liu1, Oliver Looker1, Emma McHugh1, Molly Parkyn Schneider1, Paul McMillan1,3, Eric Hanssen1,4, and Matt Dixon1 1Department of Biochemistry and Molecular Biology, 3Biological Optical Microscopy Platform, 4Advanced Microscopy Facility Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia

E-mail: ltilley@unimelb.edu.au

http://www.trybooking.com/291252

MONDAY 18 SEPTEMBER 2017

1.00pm – 4.15PM Nursing and Midwifery Research Symposium

4.00PM – 5.30PM WAHTN Clinical Trials Forum

TUESDAY 19 SEPTEMBER 2017

6.30PM – 9.00PM RACGP CPD Education Series: Healthy Living After Cancer

WEDNESDAY 20 SEPTEMBER 2017

9.00AM – 11.00AM Workshop Taking heart when your heart sinks - communication challenges in cancer care

12.00PM – 2.30PM Lunchtime Lecture & Education Session: ‘Clinical trial and registry initiatives’ and ‘Biostatistcal considerations when planning your research study’

THURSDAY 21 SEPTEMBER 2017

7.00AM – 8.30AM Investigator Good Clinical Practice, National Health & Medical Research Council and Regulatory Updates 2016 – 2017

1.30PM – 2.30PM Platform Trials Lecture ‘The value proposition for clinical trials to improve healthcare’

6.00PM – 8.00PM A Night Out with Research: Junior Doctor and Medical Student Information Evening

Hospitality | Compassion | Respect | Justice | Excellence

For more information or to register please visit www.sjog.org.au/researchweek

Event Program

18 SEPTEMBER – 22 SEPTEMBER 2017

HEALTH AND MEDICAL RESEARCH WEEK

LIGHT REFRESHMENTS WILL BE SERVED IMMEDIATELY FOLLOWING THE PRESENTATION

RPH MEDICAL RESEARCH FORUM

Seminar Series 2017 5th Floor Seminar Room Medical Research Foundation Building Rear 50 Murray St, Perth WA 6000 Fridays @ 3pm Enquiries: W/Prof Markus Schlaich phone: 9224 0382 email: markus.schlaich@uwa.edu.au

TIME: FRIDAY, 20 October 2017 @ 3pm VENUE: 5th Floor Seminar Room, MRF Building, Rear 50 Murray Street PRESENTER: Professor Aleksandra Filipovska TITLE: Mitochondrial tales of mice and men

Aleksandra Filipovska received her PhD in 2002 from the University of Otago, New Zealand. From 2003-2005 she was a NZ Foundation for Research, Science and Technology Fellow at the MRC Mitochondrial Biology Unit in Cambridge, the United Kingdom. In 2006 she relocated to Australia as a NHMRC Howard Florey Fellow and established her research group at the Perkins Institute of Medical Research at the University of Western Australia. She was an Australian Research Council Future Fellow until 2014 and currently she is a NHMRC Senior Research Fellow and a Professor at UWA and the Perkins Institute of Medical Research. Her research interests are in the regulation of gene

expression by RNA-binding proteins in health and disease. Her research group uses genomic technologies to design and characterise mouse models of metabolic and cardiovascular diseases as well as cancer.

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Wellington Street

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Goderich Street Perth City

Council Carpark

Emergency News Agency Friends Shop

Reception

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St John Ambulance

Public Carpark

Blood Bank

Chest Clinic

Wellington Fair

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McIver Train Station

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Victoria Square Cathedral

Multi Storey Car Park

t e e r t S m o o n e t t i W

Brian Vivian Seminar Room Level 4

Bruce Hunt Lecture Theatre Level 2

Robin Miller Dicks Seminar Room

The Education CentreLecture theatres and

training rooms(W.A.S.O.N. Building)