F. Treatment Regimens by Category - The following abbreviations

mean:

H - ISONIAZID (300mg) E - ETHAMBUTOL (800MG),

R - RIFAMPICIN (450MG), S - STREPTOMYCIN (1g).

Z - PYRAZINAMIDE (1g),

Table 3. TREATMENT REGIMENS

Regimen

Regimen I :

2HRZE / 4HR

Regimen II :

2HRZES/1HREZ / 5HRE

Regimen III :

2HRZ / 4HR

TB Patient To BeGiven Treatment

New pulmonarysmear (+) cases

New seriously illpulmonary smear (-) cases with extensive parenchymalinvolvement

New severely ill extra-

pulmonary TB cases

Failure cases Relapse cases RAD (smear +) Other (smear +)

New smear(-) but

with minimalpulmonary TB onradiography asconfirmed by amedical officer

New extra-pulmonary

TB (not serious)

Drugs and Duration ofTreatment

HRZE for two months during the intensive phase.

HR for 4 months during the maintenance phase.

HRZES for the first two months, then HRZE for the third month during the intensive phase.

HRE for the next five months during the maintenance phase.

HRZ for 2 months during the intensive phase.

HR for 4 months during the maintenance phase.

DoseAdjustment by Body Weight

Add one tablet of INH(100mg),PZA(500mg), and EB(400mg) each for the patient with more than 50kg bodyweight before the initiation of the treatment.

Add one tablet of INH(100mg)PZA(500mg) each for the patient with more than 50 kgbody weight before the initiation of the treatment.

G. Drug dosage adjustment according to the initial body weight of

patient

Simply add one tablet of INH (100mg), PZA (500mg) and EB (400mg) each for the patient with more than 50kg body weight before the initiation of the treatment (see Table 3). Modify drug dosage within acceptable limits according to the body weight of patient weighing less than 30kg at the time of diagnosis (see Table 4).

Table 4. DRUG DOSAGE ADJUSTMENT

Drug Dose per kg body weight and maximum doseIsoniazid 5 (4-6) mg/kg, and not exceed 400mg daily

Rifampicin 10 (8-12) mg/kg, and not to exceed 600mg daily

Pyrazinamide 25 (20-30) mg/kg, and not to exceed 2g daily

Ethambutol 15 (15-20) mg/kg, and not to exceed 1.2g dailyStreptomycin 15 (12-18) mg/kg, and not to exceed 1g daily