Dominan Follicle selection in ovary
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Transcript of Dominan Follicle selection in ovary
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Dr SIVARAJ SDEPT OF PHYSIOLOGY
ALL INDIA INSTITUTE OF MEDICAL SCIENCESNEW DELHI
20/03/2013
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The mechanisms that trigger initiation of follicular growth are still not completely understood
Thought to involve bidirectional communication between germ and somatic cells through gap junctions
Paracrine factors : cytokines and growth factors (insulin-like growth factor [IGF], epidermal and fibroblast growth factors, and interleukin-1).
Lange endocrine physiology 2ed
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FSH and insulin-like-growth factor (IGF) enhance each other's ability to stimulate follicle cell function
Access of IGF II to their receptors is regulated by IGF binding proteins and specific proteases ascribed a role in DF development
Son WY et al. 2011
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Serum AMH level correlates with ovarian follicle number
AMH levels decline as the size of the follicle increases
In patients with polycystic ovary syndrome (PCOS), AMH levels are elevated,
Potential relevance in PCOS diagnosis and management
A useful clinical marker for the assessment of ovarian reserve
Broekmans FJ et al.2008
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Aromatase and Estradiol
Estradiol by DF
Granulosa cell proliferation innon DF
DF= Dominant follicle
FSH in blood
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Healthy blood supply
Accumulation of follicular fluid
Increased density of FSH receptors on its granulosa cells
Accumulation of atretogenic androgens,suchas DHT in the non DF
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As the DF grows vascularization of the theca layer increases
More efficient delivery of cholesterol to theca cells and better exposure to circulating gonadotropins
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