Does Metoclopramide Reduce the Incidence of Ileus in ...
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Does Metoclopramide Reduce
the Incidence of Ileus in
Enhanced Recovery Patients?
Crockett M, Gane D, Hayward L,
Pullyblank A
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Background• Post-operative ileus is a significant
problem
• Leads to delayed discharge
• Metoclopramide increases stomach
emptying
• Used in ERAS protocols in an attempt to
reduce ileus
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Metoclopramide• ERAS programme started November 2008
• Metoclopramide included in ERAS
protocol
• Discontinued November 2009 after
concerns from pharmacy
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Aim• Does the use of metoclopramide within an
ERAS programme reduce the incidence of
post-operative ileus?
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The ERAS Database• November 2008
• Prospective database
• 1162 patients
• 141 fields
• 92% completed fields
• Excluded patients with LOS over 12 days
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Outcome Measures• Length of stay (LOS)
• Days to passage of first flatus (FF)
• Days to bowels opening (BO)
• Ileus rate
• Nausea/vomiting rate
• Analysis using Mann-Whitney U Test
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Results - All
Pre Nov ’09 Post Nov ‘09
Total 255 611
Length of Stay 5.34 5.10 0.667
First Flatus 2.31 2.41 0.390
Bowels Open 3.29 3.45 0.348
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Pre Nov ’09 Post Nov ‘09
All Patients
Length of Stay First Flatus Bowels Open
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Results – 1yr
Nov ’08-’09 Nov ’09-’10
Total 270 269
Length of Stay 5.34 5.05 0.654
First Flatus 2.31 2.37 0.387
Bowels Open 3.29 3.53 0.158
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Nov ’08-’09 Nov ’09-’10
1yr Pre vs 1yr Post
Length of Stay First Flatus Bowels Open
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Other Analysis• Laparoscopic
• Right
• Anastomosis
• Open
• Left
• No anastomosis
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Problems• Need further data analysis
– Exclude patients with complications
– Exclude patients with social delay
• Subjective data unhelpful
– Need definitions
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Conclusion• Metoclopramide does not alter time to first
flatus or bowels opening
• Holds true when considering approach or
site of resection
• We have demonstrated that
metoclopramide does not add value to an
enhanced recovery programme
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Conclusion• Metoclopramide does not alter time to first
flatus or bowels opening
• Holds true when considering approach or
site of resection
• We have demonstrated that
metoclopramide does not add value to an
enhanced recovery programme
Thank You
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Results – Lap vs Open
Laparoscopic Open
Total 262 211
Length of Stay 4.40 6.24 0.000
First Flatus 2.16 2.54 0.001
Bowels Open 3.35 3.49 0.424
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Results – Laparoscopic
Laparoscopic Open
Pre Post Pre Post
Total143 119 111 100
Length of Stay4.52 4.26 6.39 6.08 0.670
First Flatus2.18 2.16 2.47 2.6 0.447
Bowels Open3.25 3.45 3.32 3.64 0.271
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Results – Open
Laparoscopic Open
Pre Post Pre Post
Total143 119 111 100
Length of Stay4.52 4.26 6.39 6.08 0.504
First Flatus2.18 2.16 2.47 2.6 0.609
Bowels Open3.25 3.45 3.32 3.64 0.309
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Results – Side
Right Left/Pelvis
Total 139 266
Length of Stay 4.80 5.60 0.214
First Flatus 2.51 2.22 0.003
Bowels Open 3.83 3.16 0.000
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Results - Right
Right Left + Pelvic
Pre Post Pre Post
Total74 65 135 131
Length of Stay4.84 4.75 5.97 5.21 0.924
First Flatus2.34 2.70 2.32 2.12 0.041
Bowels Open3.61 4.08 3.05 3.26 0.050
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Results – Left/Pelvis
Right Left + Pelvic
Pre Post Pre Post
Total76 31 138 189
Length of Stay4.84 4.75 5.97 5.21 0.122
First Flatus2.34 2.70 2.32 2.12 0.186
Bowels Open3.61 4.08 3.05 3.26 0.573
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Stoma
R L P
Total 226 141 436
Stomas 10 24 262
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Results – Anastomosis
Anastomosis No Anastomosis
Pre Post Pre Post
Total52 32 45 31
Length of Stay6.65 7.28 7.33 7.55 0.214
First Flatus2.11 2.34 1.71 1.91 0.202
Bowels Open2.42 2.84 1.91 2.58 0.064
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Results – No Anastomosis
Anastomosis No Anastomosis
Pre Post Pre Post
Total52 32 45 31
Length of Stay6.65 7.28 7.33 7.55 0.972
First Flatus2.11 2.34 1.71 1.91 0.124
Bowels Open2.42 2.84 1.91 2.58 0.367