Doctoral Theses 2004

207) Eldin Satti, Iman Nasr, Immunogenicity of anti-leishmaniasisvaccines in man. Fak opp: Marita Troye-Blomberg, Stockholm(Handl: Hannah Akuffo) pp 1-49, Stockholm 16 januari 2004.

208) Dzikaité, Vijolé, Studies of proteins in heme and ironmetabolism. Fak opp: Sabina Janciauskiene, Malmö (Handl: RolfHultcrantz, bihandl: Öjar Melefors) pp 1-62, Stockholm 6 februari2004.

209) Gigliotti Rothfuchs, Antonio Carlos, Interferons in immunity toChlamydia pneumoniae. Fak opp: Jan Andersson, Huddinge (Handl:Martin E Rottenberg, bihandl: Hans Wigzell) pp 1-63, Stockholm 4mars 2004.

210) Jansson, Emmelie, Pivotal role of the nuclear receptor PPARg incolon epithelial cells. Fak opp: Balfour Sartor, USA (Handl: SvenPettersson) pp 1-61, Stockholm 19 mars 2004.

211) Popov, Nikita, Expression and activity of Myc network proteinsduring cell cycle progression and differentiation. Opponent: MartinEilers, Germany (Handl: Marie Henriksson) pp 1-51, Stockholm 26mars 2004.

212) Lundin, Annelie, Diversity and persistence of Helicobacter pylori.Opponent: Johannes Kusters, Rotterdam, Nederländerna. (Handl:Lars Engstrand, delhandl: Dan Andersson) pp 1-48, Stockholm 7maj 2004.

213) Protopopova, Marina, Modulation of activity of the tumoursuppressor p53 by small molecules and damaged DNA. Opponent:Giannino Del Sal, Trieste, Italy (Handl: Galina Selivanova) pp 1-70,Stockholm 7 maj 2004.

214) Söderblom, Tomas, Effects of bacterial toxins on calciumhomeostasis in renal inflammation. Opponent: Henry LT Mobley,Baltimore, USA (Handl: Agneta Richter-Dahlfors och StaffanNormark) pp 1-46, Stockholm 14 maj 2004.

215) Tezcan-Merdol, Dilek, The Salmonella enterica virulenceplasmid; its role in bacterial adaptation to mammalian andprotozoan cells. Opponent: Mikael Skurnik, Helsinki, Finland (Handl:Mikael Rhen) pp 1- 44, Stockholm 27 maj 2004.

216) Rollman, Erik, Concepts in DNA immunization overcoming viraldiversity and enhancing plasmid immunogenicity. Opponent:

Thomas C VanCott, Rockville, USA (Huvudhandl: Britta Wahren,bihandl: Jorma Hinkula) pp 1-59, Stockholm 28 maj 2004.

217) Wilbe, Karin, Genetic dynamics of HIV-1. Opponent: Andrew JLeigh Brown, Edinburgh, UK (Huvudhandl: Thomas Leitner, bihandl:Jan Albert) pp 1-48, Stockholm 4 juni 2004.

218) Malin, Stephen, Deciphering mechanisms of transcriptionalactivation and repression in B lymphocytes. Opponent: RudolfGrosschedl, Freiburg, Germany (Handl: Sven Pettersson) pp 1-55,Stockholm 4 juni 2004.

219) Karlsson, Sture, Toxin production in Clostridium difficileOpponent: Abraham L Sonenshein, Boston, USA (Huvudhandl:Thomas Åkerlund, bihandl: Lars G Burman) pp 1-75, Stockholm 10juni 2004.

220) Higuita V, Juan Carlos, Molecular consequences of cellular UDP-glucose deficiency. Opponent: Stuart Moore, Paris, France(Huvudhandl: Monica Thelestam, bihandl: Abram Katz) pp 1-40,Stockholm 11 juni 2004.

221) Rytkönen, Anne, Molecular studies of Neisseria – host cellinteractions. Opponent: Maria Fällman, Umeå (Huvudhandl: Ann-Beth Jonsson) pp 1-54, Stockholm 1 september 2004.

222) Sandberg, Rikard, Analyses of genomic and gene expressionsignatures. Opponent: Anders Wennborg, Stockholm (HuvudhandlIngemar Ernberg) pp 1-49, Stockholm 10 september 2004.

223) Johansson, Linda, Host responses and bacterial virulence factorsin Neisseria infections. Opponent: Mari Norgren, Umeå(Huvudhandl: Ann-Beth Jonsson) pp 1-54, Stockholm 17 september2004.

224) Vogt, Anna, Heparan sulfate dependent sequestration duringPlasmodium falciparum malaria. Opponent: Patrick Duffy, Seattle,USA (Huvudhandl: Mats Wahlgren) pp 1-77, Stockholm 24september 2004.

225) Cartier, Anna, Inhibition of apoptosis by the Us3 protein kinaseof herpes simplex virus 1. Opponent: Mauro Piacentini, Rome, Italy(Huvudhandl: Maria G Masucci, bihandl: Marie Henriksson) pp 1-65,

Stockholm 1 oktober 2004.

226) Hejdeman, Bo, Studies on Medical and ImmunologicalInterventions in HIV-1 Infection. Opponent: Patrice Debré, Paris,France (Handl: Eric Sandstrom och Britta Wahren) pp 1-51,Stockholm 1 oktober 2004.

227) Navér, Lars, Perinatal HIV-1 infection. Aspects on clinicalpresentation, viral dynamics and epidemiology Opponent: KennethMcIntosh, Boston, USA (Huvudhandl: Ann-Britt Bohlin, bihandl:Anneka Ehrnst) pp 1-66, Stockholm 6 oktober 2004.

228) Wondimu, Zenebech, Expression, recognition and usage oflaminin-8 (a4b1g1, Lm-411) by monocytes and neutrophils.Opponent: Marja Ekblom, Lund (Handl: Manuel Patarroyo) pp 1-50,Stockholm 8 oktober 2004.

229) Koivula, Tuija, Clinically important mycobacteria in Guinea-Bissau, West Africa –phenotypic and genetic diversity-. Opponent:Åse Bengård, Köpenhamn, Danmark (Huvudhandl: GunillaKällenius, bihandl: Stefan B Svensson) pp 1-73, Stockholm 15oktober 2004.

230) Matskova, Liudmila, EBV membrane protein LMP2A interactionswith ubiquitin ligases and a signaling scaffold. Opponent: WolfgangHammerschmidt, München, Germany (Huvudhandl: Gösta Winberg,bihandl: Ingemar Ernberg) pp 1-85, Stockholm 15 oktober 2004.

231) Espinosa, Felix, Rotavirus in pediatric gastroenteritis inNicaraguan Children. Opp: Sigvard Olofsson, Göteborg(Huvudhandl: Hans Hallander, bihandl Roland Möllby och KåreBondesson) pp 1-50, Stockholm 16 november 2004.

232) Shi, Yu, Coreceptor usage and sensitivity to neutralization ofHIV-1 and HIV-2. Opp: Bo Svennerholm, Göteborg (Handl: JanAlbert och Eva Maria Fenyö) pp 1-51, Stockholm 26 november2004.

233) Gabrielson, Jenny, Assessing the toxic impact of chemicals usingbacteria. Opponent: Ann-Sofi Rehnstam-Holm, Göteborg(Huvudhandl: Roland Möllby, bihandl: Inger Kühn) pp 1-35,

Stockholm 26 november 2004.

234) Saravia Otten, Patricia, Studies on fibronectin binding proteins,proteases, and virulence in Staphylococcus aureus. Opponent: KeithT Holland, England (Huvudhandl: Monica Thelestam, bihandl:Staffan Arvidson, José Maria Gutiérrez) pp 1-66, Stockholm 3december 2004.

235) Hall, Håkan, T cell responses and NK cell function inexperimental autoimmune diabetes. Opp: Anne Cooke, Cambridge,UK. (Huvudhandl: Petter Höglund, bihandl: Klas Kärre) pp 1-59,Stockholm 3 december 2004.

236) Weiland, Malin, Immunodominant proteins in Giardia lamblia.Opp: Ted Nash, Bethesda, USA (Huvudhandl: Staffan Svärd,bihandl: Mats Wahlgren) pp 1-56, Stockholm 10 december 2004.

237) Klingström, Jonas, Hantaviruses – animal models, immunologyand pathogenesis.Opp: Brian Hjelle, Albuquerque, USA(Huvudhandl: Åke Lundkvist) pp 1-68, Stockholm 9 december2004.

238) Eriksson, Emma, Host control of intracellular bacterialinfections. Opp: Anders Sjöstedt, Umeå (Huvudhandl: MartinRottenberg, bihandl: Hans Wigzell och Åsa Boström Müssener) pp1-53, Stockholm 10 december 2004.

239) Termén, Stefan, Expression of cathelicidin antimicrobial peptidesin man and rat. Opp: Ylva Engström, Stockholm (Huvudhandl:Gudmundur Gudmundsson, bihandl: Birgitta Agerberth, HansWigzell) pp 1-31, Stockholm 17 december 2004.

240) Petrovic, Jelena, Analysis and manipulation of autoreactive andtumor-specific T cell responses. Opp: Tomas Olson, Stockholm(Handl: Rickard Glas) pp 1-59, Stockholm 20 december 2004.

 

Doctoral Theses 2005

 

241) Nilsson, Christina, Genome-plasticity and adaptation inHelicobacter pylori. Opp: Anthony P Moran, Galway, Irland(Huvudhandl: Staffan Normark, bihandl: Lars Engstrand) pp 1-65,Stockholm 21 januari 2005.

242) Issaeva, Natalia, Selective induction of apoptosis in tumors bysmall molecules reactivating p53. Opp: Andrej Gudkov, Cleveland,USA (Handl: Galina Selivanova) pp 1-43, Stockholm 11 februari2005.

243) Palm, Daniel, Adaptive responses during Giarda-hostinteractions. Opp: Norbert Miller, Bern, Switzerland (Huvudhandl:Staffan Svärd, bihandl: Mats Wahlgren) pp 1-35, Stockholm 18februari 2005.

244) Nilsson, Annika, Bacterial adaptation to novel selectionpressures. Opp: Daniel E Dykhuizen, New York, USA (Huvudhandl:Dan Andersson, bihandl: Mikael Rhen) pp 1-64, Stockholm 4 mars2005.

245) Lindström, Anna, Resistance to antiviral drugs in HIV and HBV.Opp: Claus Nilsen, Köpenhamn, Danmark (Huvudhandl: Jan Albert,bihandl: Jacob Odeberg) pp 1-70, Stockholm 11 mars 2005.

246) Olsson, Anna, Molecular characterization of apoptosis in B-cellchronic lymhocytic leukemia. Opp: Anders Rosén, Linköping(Huvudhandl: Lyda Osorio, bihandl: Mikael Jondal) pp 1-45,Stockholm 8 april 2005.

247) Johansson, Sofia, NK cell recognition – adaptability to hostfactors in normal and diabetic mice. Opp: Werner Held, Lausanne,Schweiz (Handl: Petter Höglund och Klas Kärre) pp 1-58, Stockholm22 april 2005.

248) Liseng, Qin, Dynamics of the HIV-2-specific immunoglobulinA(IgA) response. Opp: Anna-Lena Spetz, Stockholm (Handl:Charlotta Nilsson och Ewa Björling) pp 1-68, Stockholm 22 april2005.

249) Öberg, Linda, Influence of Ly49 inhibitory receptors and MHCclass I on T cell and NK cell function. Opp: Susanna Cardell, Lund(Huvudhandl: Klas Kärre, bihandl: Charles Sentman) pp 1-62,Stockholm 29 april 2005.

250) Haile, Melles, Studies on new tuberculosis vaccine candidates inanimal models. Opp: Uli Fruth, Geneva, Switzerland (Huvudhandl:Andrzej Pawlowski, bihandl: Stefan B Svensson, Gunilla Källenius)pp 1-70, Stockholm 3 maj 2005.

251) Arnheim, Lisen, Immunological responses in genital HPVinfections and etiology of cervical cancer. Opp: Peter L Stern,Manchester, UK (Huvudhandl: Joakim Dillner, bihandl: Hans-GustafLjunggren) pp 1-65, Stockholm 3 juni 2005.

252) Zhang, Xiangning, Immunogenicity of and apoptosis modulationby Epstein-Barr virus (EBV)-encoded latent membrane protein-1(LMP1): implications for nasopharyngeal carcinoma. Opp: LawrenceS Young, Birmingham, UK (Huvudhandl: Ingemar Ernberg, bihandl:Li Fu Hu och Bengt Fadeel) pp 1-52, Stockholm 9 juni 2005.

253) Godoy Ramirez, Karina, Flow cytometry methods for assessmentof cell-mediated immune responses. Opp: Bengt Andersson,Göteborg (Huvudhandl: Hans Gaines, bihandl: Gunnel Biberfeld) pp1-68, Stockholm 17 juni 2005.

254) Rahman, Mokhlasur, Health hazards associated withdissemination of bacterial strains in waste water recycling. Opp:Gunnel Dalhammar, Stockholm (Huvudhandl: Roland Möllby,bihandl: Inger Kühn) pp 1-66, Stockholm 15 september 2005.

255) Sandgren, Andreas, Microbial factors and host responsesaffecting severity of pneumococcal disease and pneumococcalcarriage. Opp: Jeffrey N Weiser, Philadelphia, USA (Huvudhandl:Birgitta Henriques Normark, bihandl: Staffan Normark och BarbaraAlbiger) pp 1-68, Stockholm 16 september 2005.

256) Linde, Charlotte M A, Defense peptides against mycobacteria.

Opp: Steffen Stenger, Erlangen, Tyskland (Handl: Mats Andersson)pp 1-54, Stockholm 28 september 2005.

257) Sourial, Samer, Functional studies on the interaction ofimmunoglobulins with HIV-2 envelope. Opp: Eva Maria Fenyö, Lund(Huvudhandl: Adnane Achour, bihandl: Ewa Björling, Robert Harrisoch Charlotta Nilsson) pp 1-58, Stockholm 7 oktober 2005.

258) Oxhamre, Camilla, Novel signaling pathways induced bybacterial toxine in eukaryotic cells. Opp: Maria Fällman, Umeå(Huvudhandl: Agneta Richter-Dahlfors, bihand: Teresa Frisan ochAnita Aperia) pp 1-73, Stockholm 14 oktober 2005.

259) Kivi, Mårten, Aspects of Helicobacter pylori transmission. Opp:Douglas E Berg, USA (Huvudhandl: Marta Granström, bihandl: YlvaTindberg) 1-68, Stockholm 21 oktober 2005.

260) Kugelberg, Elisabeth, Mechanisms of adaptive mutations inbacteria. Opp: Paul B Rainey, Auckland, New Zealand (Handl: Dan IAndersson) pp 1-55, Stockholm 28 oktober 2005.

261) Almqvist, Jenny, Epstein-Barr virus nuclear antigen 1, Oct &Groucho/TLE in control of promoter regulation. Opp: Paul Farrell,London, UK (Huvudhandl: Ingemar Ernberg, bihandl: GöstaWinberg) pp 1-68, Stockholm 25 november, 2005.

262) Pettersson, Fredrik, Sequestration, virulence, and futureintervention in Plasmodium falciparum malaria.Opp: Alan WThomas, NL (Handl: Mats Wahlgren) pp 1-95 , Stockholm 2december 2005.

263) Chen, Fu, Epstein-Barr virus (EBV) latent membrane proteinLMP2A. Opp: Friedeman Kiefer, Münster, Germany (Handl: IngemarErnberg) pp 1-40, Stockholm 2 december, 2005.

264) Björndahl, Meit, Lymphangiogenesis and lymphatic metastasis.Opp: Bruce Zetter, Boston, USA (Handl: Yihai Cao) pp 1-114,Stockholm 9 december 2005.

265) Iversen, Aina, Population structure and antibiotic resistance ofthe genus enterococcus in humans, animals and the environment.Opp: Arnfinn Sundsfjord, Tromsö, Norway (Handl: Inger Kühn,bihandl: Roland Möllby) pp 1- 48, Stockholm 9 december 2005.

266) Lund, Lars H, Regulation of gene and protein expression – twomodel systems. Opp: Anders Fomsgaard, Danmark (Handl: BrittaWahren) pp 1-83, Stockholm 16 december 2005.

 

Doctoral Theses 2006

267) Eidsmo, Liv, Dysregulation of receptor induced apoptosis during human Leishmaniasis: A possible mechanism of skin ulceration. Opponent: Lars E French, Geneve, Switzerland (Handl: Hannah Akuffo och Francesca Chiodi) pp 1-45, Stockholm 3 februari 2006.

268) Clevestig, Peter, HIV-1 phenotype and genetic variation in vertical transmission. Opponent: Birgitta Åsjö, Bergen, Norway (Huvudhandl: Anneka Ehrnst, bihandl: Thomas Leitner) pp 1-56, Stockholm 10 feb 2006.

269) Golovljova, Irina, Viral Zoonoses in Estonia. Hantaviruses and Tick-Borne Encephalitis virus: Identification, prevalence, serological and genetic relationships. Opponentonent: Nöel Tordo, Paris, France (Handl: Åke Lundkvist) pp 1-85, Stockholm 8 mars 2006.

270) Atlas, Ann, Immunological and virological response to antiretroviral treatment (ART) in patients infected with different HIV-1 genetic subtypes. Opponent: Birgitta Åsjö, Bergen, Norway (Huvudhandl: Francesca Chiodi, bihandl: Annette Alaeus och Anna Nilsson) pp 1-58, Stockholm 10 mars 2006.

271) Mittelholzer, Camilla Maria, Influenza virus – Protection and Adaptation. Opponent: Anders Wadell, Malmö (Handl: A Linde, M Brytting, K Brokstad) pp 1-59, Stockholm 6 april 2006.

272) Titanji, Kehmia, Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection. Opponent: Stuart Tangye, Sidney, Australia (Handl: Angelo De Milito och Francesca Chiodi) pp 1-59, Stockholm 5 maj 2006.

273) Uhlin, Michael, Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC:peptide ligands. Opponent: Sarah Rowland Jones, Oxford, UK (Handl: Victor Levitsky) pp 1-46, Stockholm 12 maj 2006.

274) Brandin, Eleonor, HIV-2 genetic evolution and viral dynamics. Opponent: Sigvard Olofsson, Göteborg (Handl: Jan Albert) pp 1-47, Stockholm 24 maj 2006.

275) Albihn, Ami, Roles of Myc and Mad in cell cycle and apoptosis.Opponent: Sven Påhlman, Lund (Handl: Marie Arsenian Henriksson) pp 1-60, Stockholm 2 juni 2006.

276) Tomenius, Henrik, Bacterial virulence and adaptation mediated by two-component system signalling. Opponent: Bernt Eric Uhlin, Umeå (Huvudhandl: Öjar Melefors, bihandl: Ute Römling) pp 1-41,

Stockholm 15 juni 2006.

277) Ahuja, Sanjay, Development of a recombinant protein vaccine against Plasmodium falciparum malaria. Opponent: Odile Mercereau-Puijalon, Paris, France (Huvudhandl: Mats Wahlgren, bihandl: Qijun Chen) pp 1-88, Stockholm 16 juni 2006.

278) Wang, Fuli, Identification of tumor suppressor genes using the approach of gene inactivation test. Opponent: Albertina De Sario, Montpeiller, France (Huvudhandl: Eugene Zabarovsky, bihandl: Georg Klein) pp 1-55, Stockholm 16 juni 2006.

279) Stavropoulou, Vaia, Role of Tripeptidyl peptidase II in cell cycle regulation and tumor progression. Opponent: Michael Brandeis, Jerusalem, Israel (Huvudhandl: Maria G Masucci, bihandl: Marie Henriksson) pp 1-53, Stockholm 31 augusti 2006.

280) Grape, Malin, Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens. Opponent: Pentti Huovinen, Turku, Finland (Handl: Göran Kronvall) pp 1-89, Stockholm 1 september 2006.

281) Chromek, Milan, Urinary tract infection and renal scarring. Opponent: Michael Zasloff, Washington DC, USA (Huvudhandl: Annelie Brauner, bihandl: Joachim Lundahl) pp 1-49, Stockholm 8 september 2006.

282) Teixeira de Matos, Cristina, Modulation of natural killler cell and T-cell functions by CD94/NKG2A receptors. Opponent: Véronique Braud, Valbonne, France (Huvudhandl: Kalle Söderström, bihandl: Klas Kärre) pp 1-49, Stockholm 11 september 2006.

283) Chen, Liying, Processing and presentation of exogenous antigen of dendritic cells. Opponent: Hans-Gustaf Ljunggren, Stockholm (Handl: Mikael Jondal) pp 1-89, Stockholm 22 september 2006.

284) Zou, JieZhi, Epstein-Barr virus latency in vivo and in vitro. Opponent: Jaap Middeldorp, Amsterdam, Holland (Handl: Ingemar Ernberg) pp 1-71, Stockholm 27 oktober 2006.

285) Hoang, Thi Thu Ha, Serodiagnosis and seroprevalence of Helicobacter pylori infection in Vietnam. Opponent: Åsa Ljungh, Lund (Huvudhandl: Marta Granström, bihandl: Phung Dac Cam, Mikael Sörberg) pp 1-61, Stockholm 9 november 2006.

286) Sjölin, Hanna, Regulation of NK cell activity – Studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection. Opponent: Raymond Welsh, Worchester, USA (Huvudhandl: Klas Kärre, bihandl: Cristina Cerboni, Maria

Johansson, Petter Höglund) pp 1-53, Stockholm 17 november 2006.

287) Haeggström, Malin, Variable surface molecules of the Plasmodium falciparum infected erythrocyte and merozoite. Opponent: Denise Mattei, Paris, France (Huvudhandl: Mats Wahlgren, bihandl: Victor Fernandez) pp 1-59, Stockholm 1 december 2006.

288) Botero Kleivan, Silvia, Identification of new proteins and biological processes in the apicomplexan Tocoplasma gondii. Opponent: Isabelle Tardieux, Paris, France (Handl: Mats Wahlgren) pp 1-41, Stockholm 11 december 2006.

289) Téllez Serra, Aleyda, Giardiasis in Leon, Nicaragua. Prevalence and protection. Opponent: Robert Harris, Stockholm (Huvudhandl: Ewert Linder, bihandl: Jadwiga Winiecka-Krusnell, Staffan Svärd) pp 1-43, Stockholm 11 december 2006.

290) Bjur, Eva, Virulence of Salmonella enterica serovar Typhimurium and innate antibacterial host responses. Opponent: Christoph Tang, London, UK (Handl: Mikael Rhen) pp 1-45, Stockholm 12 december 2006.

291) Bresso, Francesca, Genetic and molecular determinants in inflammatory bowel disease. Opponent: Annika Lindblom, Stockholm (Huvudhandl: Sven Pettersson, bihandl: Robert Löfberg) pp 1-53, Stockholm 12 december 2006.

292) Sun, Di, Epigenetics in nasopharyngeal carcinoma. Opponent: Albertina De Sario, Montpeiller, France (Huvudhandl: LiFu Hu, bihandl: Ingemar Ernberg) pp 1-64, Stockholm 14 december 2006.

293) Mo, Hao, Targeting the Myc pathway as a novel approach for cancer therapy. Opponent: Thierry Soussi, Paris, France (Huvudhandl: Marie Arsenian Henriksson) pp 1-66, Stockholm 15 december 2006.

294) Werngren, Jim, Rapid assessment of drug susceptibility and mutation to resistance i M. tuberculosis Beijing type. Opponent: M C Gutierrez, Paris, France (Handl: Sven Hoffner) pp 1-46, Stockholm 15 december 2006.

295) Nagy, Noemi, Expression and function of the small immune adaptor protein, SAP. Opponent: John Gordon, Birmingham, UK (Huvudhandl: Eva Klein, bihandl: Hans-Gustaf Ljunggren) pp 1-43, Stockholm 18 december 2006.

296) Elias, Daniel, Helminths and immunity against tuberculosis. Opponent: Carol Nacy, USA (Huvudhandl: Hannah Akuffo, bihandl: Sven Britton) pp 1-42, Stockholm 18 december 2006.

MTC Doctoral Theses 2008 321) Wartha, Florian Identification and characterization of novel virulence factors in Streptococcus pneumoniae Opponent: Sven Hammerschmidt, Munich, Germany (Huvudhandl: Birgitta Henriques Normark, bihandl: Staffan Normark) pp 1-47, Stockholm 16 januari 2008. 322) Beiter, Katharina Recognition and clearance of Streptococcus pneumoniae by the innate immune system Opponent: Malak Kolb, USA (Huvudhandl: Birgitta Henriques Normark, bihandl: Staffan Normark) pp 1-51, Stockholm 18 januari 2008. 323) Svanh, Anita Varicella immunity and vaccination Opponent: Tomas Bergström, Göteborg (Huvudhandl: Annika Linde, bihandl: Hans Gaines) pp 1-58, Stockholm 25 januari 2008. 324) Meyer-Hoffert, Ulf Antimicrobial peptides as defense molecules at the interface of the host and bacteria Opponent: Artur Schmidtchen, Lund (Huvudhandl: Birgitta Henriques-Normark, bihandl: Jens-Michael Schröder, Staffan Normark) pp 1-35, Stockholm 8 februari 2008. 325) Juréen, Pontus Molecular characterisation of antibiotic resistance in Mycobacterium tuberculosis Opponent: Viesturs Baumanis, Riga, Latvia (Huvudhandl: Sven E Hoffner, bihandl: Lars Engstrand) pp 1-52, Stockholm 4 april 2008. 326) Kader, Mohammad Abdul GGDEF-EAL domain proteins in bacterial physiology. Opponent: Iñigo Lasa Uzcudun, Navarra, Spain (Huvudhandl: Ute Römling, bihandl: Mats Wahlgren) pp 1-40, Stockholm 8 april 2008. 327) Ortlieb Guerreiro Cacais, André Immunological consequences of Epstein-Barr virus replication. Opponent: Emmanuel Wiertz, Leiden, Holland (Huvudhandl: Victor Levitsky, bihandl: Maria Masucci) pp 1-47, Stockholm 25 april 2008. 328) Tallo, Tatjana Molecular epidemiology of hepatitis A, B and C in Estonia.

Opponent: Magnus Lindh, Göteborg (Huvudhandl: Helene Norder, Bihandl: Lars Magnius, Ljudmilla Priimägi, Valentina Tefanova) pp 1-77, Stockholm 16 maj 2008. 329) Reiner, David Cell cycle and differentiation in Giardia Lamblia Opponent: Norbert Müller, Bern, Switzerland (Huvudhandl: Staffan Svärd, bihandl: Frances Gillin) pp 1-40, Stockholm 21 maj 2008. 330) Andersson, Ida Crimean-Congo hemorrhagic fever virus: Interferon-induced antiviral mechanisms and immune evasion strategies Opponent: Richard Elliott, St. Andrews, UK (Huvudhandl: Ali Mirazami, bihandl: Åke Lundkvist) pp 1-55, Stockholm 22 maj 2008. 331) Skoglund, Anna Mechanisms of genetic adaptation in Helicobacter pylori. Opponent: Arnoud van Vliet, Norwich, UK (Huvudhandl: Lars Engstrand, bihandl: Margareta Krabbe och Britta Björkholm) pp 1-46, Stockholm 23 maj 2008. 332) Maljkovic Berry, Irina Genetic aspects of HIV-1 evolution and transmission. Opponent; Andrew Leigh Brown, Edinburgh, Scotland (Huvudhandl: Thomas Leitner, bihandl: Jan Albert) pp 1-48, Stockholm 23 maj 2008. 333) Rasti, Niloofar Pursuing the fever trail. Pathogenesis of Blood-stage P. falciparum malaria & Pregnancy Opponent: Ross Coppel, Victoria, Australia (Huvudhandl: Mats Wahlgren, bihandl: Qijun Chen, Craig Wheelock) pp 1-74, Stockholm 9 juni 2008. 334) Hardestam, Jonas Hantavirus: shedding, stability and induction of apoptosis. Opponent: Göran Wadell, Umeå. (Huvudhandl: Åke Lundkvist, bihandl: Jonas Klingström) pp 1-66, Stockholm 11 juni 2008. 335) Aronsson, Linda Microbial regulation of PPAR³: Nuclear receptor networks important for colonic homeostasis Opponent: Ian Sanderson, London, UK (Huvudhandl: Velmurugesan Arulampalam, bihandl: Sven Pettersson and Jan-Åke Gustafsson) pp 1-37, Stockholm 13 juni 2008. 336) Rölle, Alexander

Natural killer cell mediated recognition of herpesviruses - Mechanisms of viral immune escape Opponent: Andrew McMichael, Oxford, UK (Huvudhandl: Klas Kärre), pp 1-76, Stockholm 16 juni 2008. 337) Forsell, Mattias Evaluation of new strategies to stimulate neutralizing antibodies against HIV-1. Opponent: Quentin Sattentau, Oxford, UK (Huvudhandl: Gunilla Karlsson Hedestam, bihandl: Richard Wyatt, NIH) pp 1-74, Stockholm 12 september 2008 338) Åkerström, Sara SARS coronavirus - The role of occessory proteins and nitric oxide in the replication cycle. Opponent: Völker Thiel, St Gallen, Schweiz (Huvudhandl: Ali Mirazimi, bihandl: Yee-Joo Tan, Åke Lundkvist) pp 1-42, Stockholm 18 september 2008 339) Blomberg, Christel Insight into the genetic characteristics of pneumococcal isolates Opponent: Peter Hermans, Nijmegen, Holland (Huvudhandl: Birgitta Henriques Normark, bihandl: Eva Morfeldt och Staffan Normark) pp 1-57, Stockholm 19 september 2008. 340) Trumstedt, Christian Innate immunity to intracellular bacterial infections Opponent: Thomas Decker, Wien, Österrrike (Huvudhandl: Martin Rottenberg, bihandl: Hans Wigzell) pp 1-70, Stockholm 26 september 2008. 341) Källman, Owe Antibiotic resistance in Gram-negative bacilli - with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae Opponent: Niels Frimodt-Möller, Köpenhamn, Danmark (Huvudhandl: Barbro Olsson-Liljequist, bihandl: Christian G Giske, Mats Kalin) pp 1-57, Stockholm 17 oktober 2008. 342) Simon, Melinda Crimean-Congo hemorrhagic fever virus: Interactions with host cell structures in viral replications Opponent: Einar Everitt, Lund (Huvudhandl: Ali Mirazimi, bihandl: Åke Lundkvist) pp 1-57, Stockholm 23 oktober 2008. 343) Birgersdotter, Anna Transcriptome based analysis of Hodgkin lymphoma: Insights into the microenvironment

Opponent: Volker Diehl, Köln, Tyskland (Huvudhandl: Ingemar Ernberg) pp 1-52, Stockholm 30 oktober 2008. 344) Tran, Thi Thanh Ha HIV-1 genotype and vertical transmission in Northern Vietnam Opponent: Birgitta Åsjö, Bergen, Norway (Huvudhandl: Francesca Chiodi, bihandl: Phung Dac Cam, Anneka Ehrnst, Anna Nilsson) pp 1-56, Stockholm 18 november 2008. 345) Bucardo, Filemon Pediatric rotavirus and norovirus diarrhea in Nicaragua Opponent: Tomas Bergström, Göteborg (Huvudhandl: Lennart Svensson, bihandl: Roland Möllby och Felix Espinoza) pp 1-71, Stockholm 4 december 2008. 346) Wang, Xiaoda Characterization of Escherichia Coli colonizing the gastrointestinal tract and urinary tract catheters. Opponent: Timo Korhonen, Helsinki, Finland (Huvudhandl: Ute Römling, bihandl: Annelie Brauner) pp 1-48, Stockholm 8 december 2008. 347) Normark, Johan Surface antigens and virulence in Plasmodium falciparum malaria Opponent: Alister Craig, Liverpool, UK (Huvudhandl: Mats Wahlgren, bihandl: Gerhard Winter) pp 1-73, Stockholm 12 december 2008. 348) Rotzén Östlund, Maria Viral respiratory infections: Diagnosis and Epidemiology Opponent: Anders Widell, Lund (Huvudhandl: Lena Grillner, bihandl: Tobias Allander, Benita Zweygberg Wirgart) pp 1-56, Stockholm 12 december 2008. 349) Asiimwe, Benon Molecular characterization of mycobacterium tuberculosis complex from Kampala, Uganda Opponent: Sebastien Gagneux, London, UK (Handl: Gunilla Källenius, Moses Jolaba, bihandl: Tuija Koivula) pp 1-30, Stockholm 18 december 2008

Doctoral Thesis 2009 350) Cagigi, Alberto HIV-1 Infection and Loss of Serological Memory: the Role of Altered Expression of B-Cell Chemokine Receptors, Timing of HAART and Impaired Antibody Affinity Maturation. Opponent: Rita Carsetti, Rome, Italy (Huvudhandl: Anna Nilsson, bihandl: Francesca Chiodi) pp1-46, Stockholm 16 januari 2009. 351) Viklund, Ing-Marie Identification and characterization of WASP and FKBP-like Protein. Opponent: Maria Fällman, Umeå (Huvudhandl: Sven Pettersson, bihandl: Pontus Aspenström) pp1-56, Stockholm 13 mars 2009. 352) Boberg, Andreas Vaccination against drug-resistant HIV. Opponent: Fabrizio Manca, Genoa ( Huvudhandl: Maria Isaguliants, bihandl: Britta Wahren, Annika Karlsson) pp 1-59, Stockholm 19 mars 2009. 353) Ridderstråle, Karin Myc oncoprotein-cofactor interactions; function, regulation and targeting. Opponent: Jonas Nilsson, Umeå ( Huvudhandl: Lars-gunnar Larsson, bihandl: Ola Söderberg, Natalie von der Lehr) pp 1-73, Stockholm 16 april 2009. 354) Chêne, Arnaud Impact of malaria on B-cell homeostasis and Epstein-Barr virus reactivation. Endemic Burkitt´s lymphoma pathogenesis. Opponent: Maria Manuel Mota, Lissabon (Huvudhandl: Mats Wahlgren, bihandl: Maria Teresa Bejarano, Adnane Achour) pp 1-50, Stockholm 17 april 2009. 355) Jonas, Kristina Signalling pathways controlling bacterial adaption. Opponent: Dieter Haas, Lausanne (Huvudhandl: Öjar Melefors, bihandl: Ute Römling) pp 1-66, Stockholm 17 april 2009. 356) Vudattu, Nalini Kumar Alternative splicing of interleukin-7. Opponent: Rhodri Ceredig, Irland (Huvudhandl: Markus Maeurer, bihandl:

Maria Masucci) pp 1-59, Stockholm 24 april 2009. 357) Gustafsson, Erik Studies on regulatory networks governing virulence gene transcription in Staphylococcus aureus Opponent: Paul Williams, Nottingham (Huvudhandl: Patric Nilsson, bihandl: Staffan Arvidson, Rune Andersson) pp 1-47, Stockholm 24 april 2009. 358) Schepis, Danika Innate and adaptive immune responses in viral and chronic inflammatory diseases. Opponent: Vincenzo Banaba, Rom (Huvudhandl: Louise Berg, bihandl: Klas Kärre) pp 1-79, Stockholm 29 april 2009. 359) Magalhaes, Isabelle CD8 alpha alpha + T-cells and immune memory. Opponent: Pedro Romero, Lausanne (Huvudhandl: Markus Maeurer, bihandl: Rigmor Thorstensson) pp 1-39, Stockholm 20 maj 2009. 360) Leiva, Byron Amoebiasis: Diagnosis and prevalence in León Nicaragua. Opponent: Agneta Aust-Kettis (Huvudhandl: Ewert Linder, bihandl: Jadwiga Winiecka-Krusnell, Roland Möllby) pp1-43, Stockholm 25 maj 2009. 361) Enge, Martin Dissecting the p53 pathway by means of small molecule-mediated reactivation and computational biology. Opponent: Michael Resnick, USA (Huvudhandl: Galina Selivanova) pp 1-35, Stockholm 28 maj 2009. 362) Vivar, Nancy Altered T cell homeostasis during HIV-1 infection: Consequences of lymphopenia and chronic T cell activation. Opponent: Franco Lori, Washington (Huvudhandl: Bence Rethi, bihandl: Francesca Chiodi) pp 1-58, Stockholm 29 maj 2009. 363) Tjellström, Bo Gut microflora associated characteristics in children with celiac disease. Opponent: Knut Lundin, Oslo ( Huvudhandl: Elisabeth Norin, bihandl: Tore Midtvedt, Lars Stenhammar) pp 1-54, Stockholm 29 maj 2009. 364) Hedström, Elisabeth

Molecular mechanisms of growth suppression by pharmacologically activated p53. Opponent: Jean-Christoph Marine, Gent (Huvudhandl: Galina Selivanova, bihandl: Joanna Zawacka-Pankau) pp 1-38, Stockholm 4 juni 2009. 365) Mphande, Fingani Annie Towards understanding the SURFIN protein family and var genes in Plasmodium falciparum. Opponent: Jurgen Kun, Tyskland (Huvudhandl: Mats Wahlgren, Bihandl: Fred Kironde, Gerhard Winter) pp 1-52, Stockholm 5 juni 2009. 366) Kis, Loránd Levente The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression. Opponent: Lawrence S. Young, Birmingham (Huvudhandl: Eva Klein, bihandl: Laszlo Szekely) pp 1-79, stockholm 5 juni 2009. 367) Huitric, Emma Drug resistance in M. tuberculosis and the charaterisation of a new anti-tuberculosis drug candidate. Opponent: Stewart Cole, Lausanne (Huvudhandl: Sven Hoffnert, bihandl: Dan Andersson, Koen Andries) pp 1-48, Stockholm 9 juni 2009. 368) Gudmundsdotter, Lindvi HIV-1 immune responses induced by natural infection or immunisation. Opponent: Harriet Robinson, USA (Huvudhandl: Britta Wahren, bihandl: Frances Gotch, Nesrina Imami, Rigmor Thorstensson) pp 1-82, Stockholm 11 juni 2009. 369) Benno, Peter Biochemical parameters reflecting the intestinal ecology of healthy adults and alterations of these parameters in patients with ulcerative colitis or rheumatoid arthritis. Opponent: Per Falk, USA (Huvudhandl: Tore Midtvedt, bihandl: Elisabeth Norin) pp 1-46, Stockholm 11 juni 2009. 370) Näslund, Tanja I Viral vectors in innate and adaptive immunity. Opponent: Gerd Sutter, München (Huvudhandl: Peter Liljeström, bihandl: Margaret Chen) pp 1-51, Stockholm 12 juni 2009.

371) Negrea, Aurel Pharmaceutical and mutational interference with virulence of Salmonella enterica serovar typhimurium. Opponent: Josep Casadesus, Sevilla (Huvudhandl: Mikael Rhen) pp 1-30, stockholm 12 juni 2009. 372) Ribacke, Ulf Parasite virulence and disease severity in Plasmodium falciparum malaria. Opponent: Manuel Llinás , Princeton (Huvudhandl: Mats Wahlgren, bihandl: Peter Nilsson) pp 1-57, Stockholm 17 juni 2009. 373) Dellacasa Lindberg, Isabel Dissemination of Toxoplasma gondii to the central nervous system _ with special reference to in vivo bioluminescence imaging Opponent: Geneviève Milon, Paris (Huvudhandl: Antonio Barragan, bihandl: Mats Wahlgren) pp 1-39, Stockholm 28 augusti 2009. 374) Kilewo, Charles Prevention of Mother-To-Child Transmission of HIV-1 Using Antiretroviral Drugs in Dar es Salaam, Tanzania Opponent: Thorkild Tylleskär, Bergen (Huvudhandl: Gunnel Biberfeld, bihandl: Fred Mhalu, Andrew Swai) pp 1-63, Stockholm 11 september 2009. 375) Gaseitsiwe, Simani Infections with HIV-1 and Mycobacterium Tuberculosis; the Role of HLA Class II Alleles and HIV-1 Phenotypes Opponent: Sven Britton, Solna (Huvudhandl: Anneka Ehrnst, bihandl: Markus Meurer, Andrzej Pawlowski, Max Essex) pp 1-55, Stockholm 14 september 2009. 376) Kling Bäckhed, Helene Genetic adaptions of Helicobacter pylori during gastric disease progression. Opponent: Stefan Bereswill, Berlin (Huvudhandl: Lars Engstrand, bihandl: Britta Björkholm) pp 1-48, Stockholm 25 september 2009 377) Xue, Yuan Mechanism of Pathological Angiogenesis in Adipose Tissue and Tumor. Opponent: Paul Trayhurn, Liverpool, UK. (Huvudhandled: Yihai Cao) pp 1-46, Stockholm 9 oktober 2009.

378) Dagerhamn, Jessica Genetic Content of Clinical Pneumococcal Isolates and its Relation to Disease Outcome Opponent: Pentti Huovinen, Åbo, Finland. (Huvudhandl: Birgitta Henriques Normark bihandl: Eva Morfeldt) pp 1-31, Stockholm 23 oktober 2009. 379) Dahlberg, Sofia Characterization of host and microbe interactions affectiog, adherence, clearance and systemic spread of S. Pneumoniae Opponent: Ingileif Jónsdóttir, Reykjavik, Island. (Huvudhandl: Birgitta Henriques Normark bihandl:Staffan Normark, Barbara Albiger) pp 1-60, Stockholm 27 november 2009. 380) Muschiol Sandra Small Molecule Inhibitors of Type III Secretion and their Effect on Chlamydia Development. Opponent: Kenneth Fields, Miami. (Huvudhandl: Birgitta Henriques Normark bihandl: Staffan Normark, Agathe Subtil) pp 1-70, Stockholm 4 december 2009. 381) Nguyen, Thi Viet Ha Diagnosis and Treatment of Helicobacter Pylori Infection in Vietnamese Children Opponent: Peter Unge, Örebro. (Huvudhandl: Marta Granström, bihandl: Gia Khanh Nguyen, Mikael Sörberg.) pp 1-67, Stockholm 11 december 2009

Doctoral Theses 2010

382) Johansson, Susanne

Natural Killer Cells and Antibody-mediated Effects in Human Immundeficiency Virus Infection

Opponent: Sarah Rowland-Jones, Oxford. (Huvudhandl: Louise Berg, bihandl: Maria Johansson, Britta Wahren, Jorma Hinkula) pp 1- 83, Stockholm 29 januari 2010.

383) Vaz, Paula

Pediatric HIV infection in Maputo, Mozambique. Horizontal transmission, treatment outcomes and drug resistance

Opponent: Marc Cotton, Stellenbosch, South Africa. (Huvudhandl: Sören Andersson, bihandl: Gunnel Biberfeld, Stehphane Blanche.) pp 1-82, Stockholm 11 februari, 2010

384) Colque-Navarro, Patricia

Serum antibodies against Staphylococcus aureus antigens in healthy individuals and patients with invasive infections

Opponent: Cecilia Rydén, Uppsala. (Huvudhandl: Roland Möllby.) pp 1-63, Stockholm 26 mars, 2010

385) Sandhu, Kuljeet

Networks in Epigenetics

Opponent: Ola Hermansson, Stockholm.(Huvudhandl: Rolf Ohlsson, bihandl: Chandrasekhar Kanduri, Tomas Ekström.) pp 1-27, Stockholm 6 maj, 2010.

386) Lindberg, Matilda

The Human Gastric Microbiota in Health and Disease.

Opponent: Siv Ahrné, Lund. (Huvudhandl: Lars Engstrand, bihandl: Cecilia Jernberg, Stefan Roos) pp 1-38, Stockholm 7 maj, 2010.

387) Haeggman, Sara

Evolution of Beta-lactam Resistance in Klebsiella pneumoniae

Opponent: Mark Gniadkowski, Warsawa. (Huvudhandl: Sven Löfdahl, bihandl: Lars G Burman, Barbro Olsson-Liljequist.) pp 1-32, Stockholm 11 maj, 2010

388) Haraldsson, Klas

NotI Genome Scanning to Identify Unknown Cancer Associated Genes in Major Human Epithelial Malignancies

Opponent: Zoltan Marcsek, Ungern. (Huvudhandl: Eugene Zabarovsky, bihandl: Vladimir Kashuba) pp 1-37, Stockholm 1 juni, 2010

389) Andres Sönke

Persistent Helicobacter pylori Infection and Host Response.

Opponent: Marianne Quiding-Järbrink, Göteborg. (Huvudhandl: Markus Maeurer, bihandl: Mikael Rhen) pp 1-48, Stockholm 11 juni, 2010.

390) Zhao, Ying

Pharmacological Targeting of p53 Pathway Alterations in Tumors

Opponent: Giovanni Blandino, Rom. (Huvudhandl: Galina Selivanova, bihandl: Wenjie Bao) pp 1-29, Stockholm 17 juni, 2010

391) Brauner, Hanna

Diabetes Pathogenesis - Role of Natural Killer Cells, T Cells and a Novel Neuropeptide

Opponent: Agnès Lehuen, Paris. (Huvudhandl: Petter Höglund, bihandl: Klas Kärre) pp 1-52, Stockholm 18 juni, 2010

392) Reyes Navarrete, Daniel

Escherichia coli flora and Diarrhea in Nicaraguan infants.

Opponent: Erik Kihlström, Linköping. (Huvudhandl: Roland Möllby, bihandl: Inger Kühn, Félix Espinosa) pp 1-52, Stockholm 10 september, 2010.

393) Bwanga, Freddie

Rapid Tests for multidrug resistant tuberculosis in low income settings

Opponent: David Moore, London. (Huvudhandl: Sven Hoffner, bihandl: Moses Joloba, Melles Haile) pp 1-46, Stockholm 24 september, 2010

394) Lebbad, Marianne

Molecular Diagnosis and Charcterization of Two Intestinal Protozoa: Entamoeba histolytica & Giardia intestinalis

Opponent: Theo Mank, Haarlem. (Huvudhandl: Staffan Svärd, bihandl: Mats Wahlgren, Jan Andersson) pp 1-57, Stockholm 24 september, 2010.

395) Lamprokostopoulou, Agaristi

Role of c-di-GMP signalling in bacterial-host interactions

Opponent: Michael Hensel, Osnabrück. (Huvudhandl: Ute Römling, bihandl: Mikael Rhen) pp 1-59, Stockholm 30 september, 2010

396) Lovén, Jakob

Functional studies of microRNAs in development and cancer

Opponent: Chi Van Dang, Baltimore. (Huvudhandl: Marie Arsenian Henriksson) pp 1-54, Stockholm 1 oktober, 2010.

397) Wahlgren, John

Influenza A virus in natural and artificial environments

Opponent: Jorma Hinkula, Linköping. (Huvudhandl: Björn Olsen, bihandl Åke Lundkvist, Kerstin Falk, Jonas Waldenström) pp 1-57, Stockholm 8 oktober, 2010

398) Joannin, Nicolas

Antigenic variation in Plasmodium falciparum: understanding the RIFIN protein family

Opponent: Sue Kyes, Oxford. (Huvudhandl: Mats Wahlgren, bihandl: Björn Andersson) pp 1-34, Stockholm 18 oktober, 2010.

399) Dahl Ejby Jensen, Lasse

Mechanisms of malignant and non-malignant angiogenesis using zebrafish models

Opponent: Amato J Giaccia, Stanford. (Huvudhandl: Yihai Cao, bihandl Giselbert Hauptmann) pp 1-89, Stockholm 22 oktober, 2010

400) Karlsson, Diana

Studies on emergence and spread of antibiotic resistant Streptococcus pneumoniae

Opponent: Ann-Beth Jonsson, (SU) Stockholm. (Huvudhandl: Patric Nilsson, bihandl: Birgitta Henriqes-Normark, Rune Andersson) pp 1-84, Stockholm 12 november, 2010.

401) Connolly-Andersen, Anne-Marie

Pathogenesis of an emerging pathogen - Crimean-congo Hemorrhagic Fever virus

Opponent: Christina Spiropoulou, Atlanta (Huvudhandl: Ali Mirazimi, bihandl: Karl-Erik Magnusson, Lennart Svensson) pp 1-64, Stockholm 3 december, 2010

402) Skar, Helena

HIV Evolution: Theoretical Framework and Practical Applications

Opponent: Edward C. Holmes, Pennsylvania. (Huvudhandl: Jan Albert, bihandl: Thomas Leitner) pp 1-61 Stockholm 3 december, 2010

403) Nowroozalizadeh, Salma

Activation and dysregulation of innate immunity in HIV-1 and HIV-2 infections

Opponent: Kristina Broliden, Solna. (Huvudhandl: Marianne Jansson, bihandl: Ali Harandi) pp 1-55, Stockholm 13 december, 2010