C URRICULUM V ITAE

Professor Dr Fazal SubhanDepartment of Pharmacy,University of Peshawar,Peshawar, N.W.F.P.Pakistan.

Office: 091-9216750Residence: 092-5610876

: 03018805966

@: fazal_subhan@upesh.edu.pkfsubhan2000@yahoo.com

Research Interests:  Prof. Dr Fazal Subhan and his research group is actively involved on

testing compounds from both synthetic and natural origin for their utility in pain,

inflammation, pyrexia, depression, anxiety, dependence, tolerance, and vomiting. Research

in his laboratories is also conducted in the area of neuropathy where the pathological

condition is induced in a rat and mice models. The pain models of allodynia and vulvodynia

induced by diabetes, chemotherapeutic agents or surgical procedures are well established

and the compounds of interest are evaluated for their effectiveness in neuropathic pain

conditions with the help of von Frey hairs and other algesiometric techniques. Research is

also in progress both at the preclinical and clinical levels for testing newly developed

antipsychotic formulations in comparison to the conventional formulations for their safety

and therapeutic efficacy. His research group is also working on natural products against

chemotherapeutic drugs induced vomiting and opioid withdrawal syndrome. Biochemical

and neurotransmitters studies are conducted for correlating behavioral findings and

elucidation of mechanism of action of compounds of interest.

Currently, two projects titled "Synthesis and screening of GABA derivatives as potential

therapeutic agents for the treatment of neuropathic pain" and "Novel targeted heterocyclic

compound(s) beta hydroxy ketone derivative-Potential candidates for Alzheimer's disease"

granted by Higher Education Commission (HEC) of Pakistan under NRPU scheme are in

progress.

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Research facilities:

Prof Subhan has established state of the art experimental research facilities at the department

of Pharmacy, University of Peshawar where research students can work and learn in friendly

environment. These research facilities include: 

 

Animal house having breeding and keeping facilities for rats, mice, pigeons, rabbits

and guinea pigs.

Behavioral laboratory equipped with computer assisted video recording facility for

experiments on live animals such as analgesia, anti-inflammatory, antipyretic, anti-

emetic, locomotor, anxiolytic and antidepressant activities. 

Toxicological laboratory with facility of tissue embedding and staining, microtome

for tissue slicing and a microscope attached with digital camera for histopathological

examination of tissue slides. 

Applied Pharmacology laboratory with facilities of -80 oC fridge, tissue

homogenizers for processing tissue, temperature controlled centrifuge, HPLC with UV

and ECD detectors. ESA, Electrochemical Detector is equipped with high sensitivity

analytical cell and guard cell for measurement of minute quantities of neurotransmitters

and other biomarkers in biological fluids including different brain areas of interest. 

Universal organ bath, Oscillograph and chart recorders for performing experiments

on isolated tissues.

Education:

Institute Degree Period Subject of StudyWelsh School of Pharmacy,Cardiff University of Wales, UK. Ph.D. 1996-2000. Pharmacy

(Pharmacology)Faculty of Pharmacy,University of the Punjab, Lahore, Pakistan.

M.Phil. 1991-1992. Pharmacy(Pharmacology)

Faculty of Pharmacy,University of the Punjab, Lahore, Pakistan.

M.Pharmacy 1984-1985. Pharmacy(Pharmacology)

Faculty of Pharmacy, Gomal university, D.I.Khan,Pakistan.

B-Pharmacy 1980-1984. Pharmacy

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Special training:

Successfully completed courses related to animal handling and experimentation (Module 1, 2, 3 and 4) organised by the institute of Biology, University of Wales, Cardiff, UK.

Personal animal licence holder authorised to perform experiments on standard laboratory animals including Rats, Mice, Guinea pigs and Rabbits in UK.

Teaching Experience:

Employer Position Duration Job description

Department of Pharmacy, University of Peshawar, Pakistan.

ProfessorMarch 21, 2009 to-date

ProfessorTeaching and research

Department of Pharmacy, University of Peshawar, Pakistan.

Associate Professor

June 30, 2003 March 20, 2009.

Teaching and research in the field of Pharmacy

Department of Pharmacy, University of Peshawar, Pakistan.

Lecturer

Oct 8, 1987 to June 29, 2003.

Teaching and research in the field of Pharmacy

Faculty of Pharmacy,Gomal University, D.I.Khan.

LecturerOct 1, 1986 to Oct 7, 1987.

Teaching the subjects of Pharmacy.

Administrative Experience:

Successfully completed three years term as chairman of Department of Pharmacy University of Peshawar- (27-08-2008 to 26-08-2011)

Distinctions/ Memberships:

First Class First Position in Master of Pharmacy.

COT Scholarship for Ph.D. studies abroad.

Overseas Research Scholarship (ORS) award for the Year 1997&98 (U.K Higher Education Research Award for Overseas Students).

Higher Education Commission (HEC) of Pakistan recognised supervisor in the field of Pharmacy/Pharmacology

Member of the drug court.(2004-2015)

Member of the National Pharmacy Curriculum Committee.

Member of Ethical committee of Department of Pharmacy, UoP.

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Member of GSC Department of Pharmacy, UoP.

Member of GSC department of Zoology, UoP

Presentation in International Conferences During Ph.D. Studies:

British Pharmaceutical Conference held in September 1999 at Cardiff, UK.

British Pharmaceutical Conference held in September 1998 at Eastbourn, UK.

BAP/CCNP Conference held in July 1997 at Cambridge, UK.

Teaching Experience:

Teaching the subject of pharmacology to pharmacy students.

Supervising and teaching to M.Phil./Ph.D. scholars in field of pharmacy

(Pharmacology).

Research Projects Completed/In-progress:

1. Pharmacological investigation on some indigenous plants/ Hypericum perforatum,

potentially useful for depression, pain and addiction (completed).

2. Studies on selective serotonin reuptake inhibitor (SSRI) fluoxetine in the

management of opioid (heroin) dependence and analgesia (completed).

3. Biopharmaceutical profile of risperidone (completed)

4. Effect of fasting on serum lithium in preclinical and clinical models (completed)

5. Effect of Bacopa monnieri on morphine dependence and tolerance to analgesia in

animal models (completed).

6. Evaluation of some selected medicinal plants and their combinations in cisplatin

induced vomiting in vomit model(s); behavioral neurochemical correlates

(completed).

7. Effects of selected medicinal plants combination on hypertension, dyslipidemia and

depression (in progress).

8. Evaluation of antidepressants on bacterial resistance to antibiotics.(completed)

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9. Development and comparative clinical safety and effectiveness evaluation of

controlled release tablets vs. conventional tablets of olanzapine & prochlorperazine

(completed)

10. Preclinical evaluation of selected synthetic bioisosteric nitrogen containing salicyl

alcohol derivatives in inflammation, ulcergeninicity and pain modalities

(completed).

11. Hepatotoxicity and nephrotoxicity of morphine and illicit street heroin and its

amelioration by extract of Bacopa monniera (completed).

12. Comparative evaluation of selected antioxidants and their combination in cisplatin

induced vomiting in pigeons (completed).

13. Synthesis and screening of GABA derivatives as potential therapeutic agents for the

treatment of neuropathic pain. (awarded under NRPU)

14. Novel targeted heterocyclic compound(s) beta hydroxy ketone derivative-Potential

candidates for Alzheimer's disease.

National Research Collaborations:

Professor Nazar Ul Islam, Sarhad University of Science and Technology, KPK, Peshawar.

Professor Dr Syed Muhammad Sultan, Head of psychiatry department, Khyber teaching hospital, Peshawar.

Professor Jawad Ahmed, Institute of Basic Medical sciences,Khyber Medical University, Peshawar, KPK.

Professor Anwar-ul-Hassan Gilani, Pakistan Council for Science and Technology and Aga Khan University, Karachi, Sindh.

Dr. Muhammad Ayaz, Lecturer, Pharmacy Department, University of Malakand Khyber PukhtoonKhawa 18000, Pakistan

Professor Nasiara Karim, department of pharmacy, university of Malakand, Chakdara, KPK.

Dr. Khalid Rauf. Assistant professor, department of pharmacy, COMSATS institute of information technology, Abbotabad, KPK.

Dr Ihsan Ullah, assistant professor, department of pharmacy, University of Swabi, Swabi KPK.

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Zia Ahmed, Department of Pharmacy, Hazara University, Havelian campus, Hazara KPK.

International Research Collaborations:

Professor Robert D.E. Sewell, Welsh School of Pharmacy, Division of

Pharmacology, Cardiff University of Wales, UK.

Professor, John A. Rudd, School of biomedical Sciences, Faculty of mediceine. The

Chinese University of Hong Kong.

Shafiqur Rahman, Professor of Pharmacology, Department of Pharmaceutical

Sciences South Dakota State University College of Pharmacy 1055 Campanile

Avenue  Avera Health and Science Center, SAV 265 Brookings, SD 57007 USA.

Dr. Faiz Ur Rahman, PhD Post-Doctoral Research Fellow Laboratory of Supra-

molecular and Organometallic Chemistry Fudan University, Shanghai, P. R. China.

Research Grants:

S# Research Project name Total Research grant

Source Remarks

1 Higher Education commission grant for the maintenance

Rs. 10,00000/- HEC granted Completed

2 Pharmacological Investigation on some indigenous plants/Hypericum perforatum, potentially useful for depression, pain and addiction

Rs. 40,000/- University of Peshawar granted

Completed

3 Selected Serotnin Re-uptake Inhibitor (SSRI), fluxetine, drug dependence and analgesia

Rs. 1,80,000/- University of Peshawar granted

Completed

4 Biopharmaceutical profile of Risperidone

Rs. 4,95,000/- University of Peshawar granted

Completed

5 Effects of Selected Medicinal Plants combination on Hypertension, Dyslipidemia and Depression

Rs. 2,76,500/- University of Peshawar granted

Completed

6 Evaluation of antidepressants Rs. 4,62,648/- University of Peshawar completed

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on Bacterial resistance to antibiotics

granted

7 Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain.

Rs.7,153,222/- HEC under NRPU In progress

8 Novel targeted heterocyclic compound(s) beta hydroxy ketone derivative-Potential candidates for Alzheimer's disease.

Rs.58,86,560/- HEC under NRPU Approved.

List of M.Phil and Ph.D Students (Supervised): List of Ph.D. Students:

S.# Name Research Title Year of completion

1 Amir Bad Shah

Development And Evaluation Of Extended Release Matrix Tablets Of Risperidone,

Olanzapine and Prochlorperazine Maleate (AntiPsychotic Drugs)

11/06/2010

2 Khalid Rauf Effect of Bacopa Monnieri on Morphine Dependence and Tolerance to Analgesia in

Animal Models

08/03/2012

3 Sami Ullah Development and Comparative Evaluation of Controlled Release Tablets vs. Conventional

Tablets of Olanzapine and Prochlorperazine for Clinical Safety and Therapeutic Efficacy

25/6/2014

4 Gowhar Ali Preclinical Evaluation of Selected Synthetic Bioisosteric Nitrogen Containing Salicyl Alcohol

Derivatives in Inflammation, Pyrexia,

18/2/2014

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Ulcerogenicity and Pain Modalities

5 Ihsan Ullah Evaluation of some selected medicinal plants and their combinations in Cisplatin induced Vomiting in Vomit model (S); Behavioral Neurochemical

correlates

03/10/2013

6 Rehmat Shah Preclinical and clinical evaluation of selected antiphsychotics induced toxicity, biochemical

and histoathological approach

Thesis submitted

7 Shehla Akbar Evaluation of 6-methoxyflavanone on anxiety and neuropathic pain models; a behavioural and

pharmacokinetic study

Completed

2017

8 Khwaja Fawad ‘Evaluation Of Synthesized Bis-Aminomethylene Derivatives Of Hydroquinone For Anti-

Inflammatory, Anti-Pyretic, Anti-Nociceptive, And Gastric Ulcerogenic Activities In Animal

Models’’

Experimental completed

10 Muhammad Shahid

Pharmacological screening of compounded topical preparations in the rodent neuropathic

pain paradigms

In progress

11 Nisar Ahmad Synthesis and pharmacological profiling of gabapentin and pregabalin derivatives as

potential therapeutic agents in the treatment of neuropathic pain

Experimental completed

12 Muhammad Asif

Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of

neuropathic pain.

Enrolled

13 Najeeb Ullah Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of

neuropathic pain.

Enrolled

14 Rahim Ullah

(Co-Super.)

Evaluation of selected flavonoids in Neuropathy and Alzheimer

Enrolled

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List of M.Phil. Students:S# Name Research Title Year of

completion

1 Munasib Khan Pharmacological investigation on indigenous plant, HYPERICUM PERFORATUM, potentially useful for pain and addiction

27/7/2005

2 Rukhsana Ghafar

(Co-Super.)

Phytochemical and biological evaluation of Valeriana Wallichii plant

25/02/2006

3 Muhammad Tayyab Abbas

Studies on selective serotonin reuptake inhibitor (SSRI) Fluoxetin in the management of opioid (Heroin) dependence and analgesia

15/5/2007

4 Nasiara Pharmacological investigation of indigenous plant Valeriana wallichii for depression in animal models

07/1/2008

5 Nematullah Khan

‘’Effect of Hypericum Perforatum on Naloxone induced Heroin withdrawl symptoms and negative motivational properties’’

27/5/2009

6 Zia Ahmed ‘’Effect of fasting on serum lithium in preclinical and clinical models

26/10/2009

7 Muzaffar Abbas

Effect of Bacopa Monniera on pain perception and depression in animal models

13/01/2009

8 Muhammad Ayaz

Evaluation of anti-depressants on bacterial resistance to antibiotics

01/11/2012

9 Muhammad Shahid

‘’Heoatitixicity and Nephrotoxicity of Morphine and Illicit Street Heroin and its Amelioration by Extract of Bacopa Monniera

20/11/2013

10 Javaid Alam Comparative Evaluation of Selected Antioxidants and their Combinations in Cisplatin Induced Vomiting in Pigeons

14/4/2014

11 Urooj Aman Evaluation of Methanol Extract Of Passiflora Incarnata on Pain and Anxiety Models

23/01/2015

12 Jehanzeb Evaluation of topical gabapentine in animal 30/05/2016

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models of peripheral neuropathic pain

13 Anum Muzaffar

Clinical investigation on the impact of cannabis abuse on the thyroid hormones and associated psychiatric manifestations.

18/11/2016

14 Amna Nisar Defensive of vulvudynia in diabetic and non.diabetic middle age female and its association with psychosexual problem

19/07/2017

List of Research Publications:

1. Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Abdul Sadiq,

Gowhar Ali, Muhammad Ovais,Muhammad Shahid, Ashfaq Ahmad, Abdul Wadud,

Mohamed El-Shazly, Nisar hmad, Sajjad Ahmad.Anti-Alzheimer's studies on β-

sitosterol isolated from Polygonum hydropiper L. Frontiers in Pharmacology (DOI:

10.3389/fphar.2017.00697) (Accepted) (IF: 4.4)

2. Muhammad Shahid, Fazal Subhan, Nisar Ahmad, Robert D.E. Sewell. The

flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and

hypoalgesia. Biomedicine and Pharmacotherapy (Accepted, 2017) (IF: 2.326)

3. Muhammad Shahid, Fazal Subhan, Gowhar Ali, Ihsan Ullah, Javaid Alam, Sami

Ullah, Khalid Rauf. Neuroprotective effect of Bacopa monnieri against morphine-

induced histopathological changes in the cerebellum of rats. Pakistan Journal of

Pharmaceutical Sciences (Accepted, 2017). (IF: 0.649)

4. Khwaja Fawad, Nazar Ul Islam, Fazal Subhan, Muhammad Shahid, Gowhar Ali,

Faiz-Ur Rahman, Wajahat Mehmood4, Nisar Ahmad. Novel hydroquinone

derivatives alleviate pain, inflammation and pyrexia without aspirin-like gastric

ulcerogenicity. Tropical Journal of Pharmaceutical Research. ( Accepted, 2017) (IF:

0.569)

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5. Nisar Ahmad, Fazal Subhan, NazarUl Islam, Muhammad Shahid, Faiz Ur Rahman,

Robert D.E. Sewell. Gabapentin and its salicylaldehyde derivative alleviate allodynia

and hypoalgesia in a cisplatin-induced neuropathic pain model. European journal of

Pharmacology.( doi.org/10.1016/j.ejphar.2017.08.040) (In press, 2017) (IF: 2.896)

6. M Shahid, F Subhan, N Ahmad, I Ullah. A bacosides containing Bacopa monnieri

extract alleviates allodynia and hyperalgesia in the chronic constriction injury model

of neuropathic pain in rats BMC complementary and alternative medicine 17 (1),

293. (2017) (IF: 1.987)

7. Shahid M, Subhan F, Ahmad N, Ullah I. A bacosides containing Bacopa

monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction

injury model of neuropathic pain in rats. BMC Complementary and Alternative

Medicine 17:293. (2017) (IF: 1.987)

8. Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J. Neuroprotective and

Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants.

Frontiers in Aging Neuroscience (2017) 9:168. (IF: 4.348)

9. Ahmad N, Subhan F, Islam NU, Shahid M, Rahman FU, Fawad K. A Novel

Pregabalin Functionalized Salicylaldehyde Derivative Afforded Prospective Pain,

Inflammation, and Pyrexia Alleviating Propensities. 350, Archiv der Pharmazie

(2017). (IF: 2.043)

10. S Akbar, F Subhan, N Karim, U Aman, S Ullah, M Shahid, N Ahmad..

Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral

and pharmacokinetic approach. European journal of pharmacology 801, 19-27.

(2017). (IF: 2.9)

11. Shahid, M., Subhan, F., Ahmad, N., Ali, G., Akbar, S., Fawad, K., Sewell, R.,.

Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic

nerve constriction injury neuropathic pain model. European Journal of Pain (2017).

(I.F; 3.019).

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12. Alam, J., Subhan, F., Ullah, I., Shahid, M., Ali, G., Sewell, R.D.,. Synthetic and

natural antioxidants attenuate cisplatin-induced vomiting. BMC Pharmacology and

Toxicology 18, 4. (2017) (I.F; 2.288).

13. Alam, J., Subhan, F., Ullah, I., Shahid, M., Ali, G., Sewell, R.D.,. Erratum to:

Synthetic and natural antioxidants attenuate cisplatin-induced vomiting. BMC

Pharmacology and Toxicology 18, 9. (2017) (I.F; 2.288).

14. Ullah, I., Subhan, F., Lu, Z., Chan, S.W., Rudd, J.A.,. Action of Bacopa monnieri to

antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew). Journal

of Pharmacological Sciences 133, 232-239 (2017). (I.F; 2.415)

15. Ayaz, M., Subhan, F., Sadiq, A., Ullah, F., Ahmed, J., Sewell, R.,. Cellular efflux

transporters and the potential role of natural products in combating efflux mediated

drug resistance. Frontiers in bioscience (Landmark edition) 22, 732. (2016) (IF;

2.497)

16. S Akbar, F Subhan, N Karim, M Shahid, N Ahmad, G Ali, W Mahmood 6-

Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the

streptozotocin-induced diabetic neuropathic pain. Biomedicine & Pharmacotherapy

84, 962-971. (2016). (IF: 2.759)

17. Muhammad Ayaz , Muhammad Junaid, Farhat Ullah, Abdul Sadiq, Fazal Subhan,

Mir Azam Khan, Waqar Ahmad, Gowhar Ali, Muhammad Imran, and Sajjad

Ahmad. Molecularly Characterized Solvent Extracts and Saponins from Polygonum

hydropiper L. Show High Anti-Angiogenic, Anti-Tumor, Brine Shrimp, and

Fibroblast NIH/3T3 Cell Line Cytotoxicity Frontiers in Pharmacology

www.frontiersin.org.7: 24 (2016) (IF: 3.80)

18. Urooj Aman, Fazal Subhan, Muhammad Shahid, Shehla Akbar, Nisar Ahmad,

Gowhar Ali, Khwaja Fawad, Robert DE Sewell. Passiflora incarnata attenuation of

neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic

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antinociceptive and behavioural mechanisms. BMC Complementary and Alternative

Medicine 16:1. (2016) (IF: 2.020)

19. Muhammad Shahid, Fazal Subhan, Ihsan Ullah, Gowhar Ali, Javaid Alam, Rehmat

Shah. Beneficial effects of Bacopa monnieri extract on opioid induced toxicity.

Heliyon 2:e00068. (2016).

20. Zia Ahmed, Fazal Subhan, Saba Ahmed, Qazi Abdur Rasheed, Sagheer Ahmed,

Muhammad Shahid, Saeed Farooq. Development of fixed dose combination tablets

of aripiprazole plus divalproex sodium and their simultaneous determination using

HPLC-UV. Drug Development and Industrial Pharmacy:1-39. (2016) (IF: 2.101)

21. Mohammad Ayaz, Fazal Subhan, Jawad Ahmed, Arif-ullah Khan, Sajid Hussain.

Citalopram and venlafaxine differentially augments antimicrobial properties of

antibiotics. Acta Poloniae Pharmaceutica 72:1269-1278. (2015) (IF: 0.737)

22. Gowhar Ali, Fazal Subhan, Muzaffar Abbas, Jehan Zeb, Muhammad Shahid,

Robert DE Sewell. A streptozotocin-induced diabetic neuropathic pain model for

static or dynamic mechanical allodynia and vulvodynia: validation using topical and

systemic gabapentin. Naunyn-Schmiedeberg's Archives of Pharmacology DOI:

10.1007/s00210-015-1145-y. (2015) (IF: 2.471)

23. Rehmat Shah, Fazal Subhan, Gowhar Ali, Ihsan Ullah, Sami Ullah, Muhammad

Shahid, Nisar Ahmad, Khwaja Fawad. Olanzapine induced biochemical and

histopathological changes after its chronic administration in rats. Saudi

Pharmaceutical Journal, DOI:10.1016/j.jsps.2015.06.006. (2015) (IF: 1.283)

24. Muhammad Ayaz, Fazal Subhan, Jawad Ahmed, Arif-ullah Khan, Farhat Ullah,

Ihan Ullah, Gowhar Ali, Sajid Hussain. Sertraline enhances the activity of

antimicrobial agents against pathogens of clinical relevance. Journal of Biological

Research-Thessaloniki 22:4. (2015) (IF: 0.65)

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25. Ihsan Ullah, Fazal Subhan, Muhammad Ayaz, Rehmat Shah, Gowhar Ali, Ikram Ul

Haq, Sami Ullah. Anti-emetic mechanisms of Zingiber officinale against cisplatin

induced emesis in the pigeon; behavioral and neurochemical correlates. BMC

Complementary and Alternative Medicine 15:1. (2015) (IF: 2.020)

26. Muhammad Ayaz, Muhammad Junaid, Fazal Subhan, Farhat Ullah, Abdul Sadiq,

Sajjad Ahmad, Muhammad Imran, Zul Kamal, Sajid Hussain, Syed Majid Shah.

Heavy metals analysis, phytochemical, phytotoxic and anthelmintic investigations of

crude methanolic extract, subsequent fractions and crude saponins from Polygonum

hydropiper L. BMC Complementary and Alternative Medicine 14:465. (2014) (IF:

2.020)

27. Ihsan Ullah, Fazal Subhan, John A Rudd, Khalid Rauf, Javaid Alam, Muhammad

Shahid, RD Sewell. Attenuation of cisplatin-induced emetogenesis by standardized

Bacopa monnieri extracts in the pigeon: Behavioral and neurochemical correlations.

Planta Medica 80:1569-1579. (2014) (IF: 2.152)

28. Muhammad Shahid, Fazal Subhan. Comparative histopathology of acetaminophen

induced hepatotoxicity in animal models of mice and rats. Pharmacologyonline

(2014) 3:32-43.

29. Muhammad Shahid, Fazal Subhan. Protective effect of Bacopa monniera methanol

extract against carbon tetrachloride induced hepatotoxicity and nephrotoxicity.

Pharmacologyonline 2:18-28. (2014)

30. Waqar Ahmad, Imran Khan, Mir Azam Khan, Manzoor Ahmad, Fazal Subhan,

Nasiara Karim. Evaluation of antidiabetic and antihyperlipidemic activity of

Artemisia indica linn (aeriel parts) in Streptozotocin induced diabetic rats. Journal of

Ethnopharmacology 151 (2014) 618–623. (IF: 2.998)

31. Zia Ahmed, Fazal Subhan, Muhammad Tahir Shah and Saeed Farooq. Effect of

fasting on serum lithium levels: An experimental study in animal models. Pakistan

Journal of Pharmaceutical Sciences. (2014), 27, 33-37. (IF: 0.682)

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32. Sami Ullah, Fazal Subhan, Syed Muhammad Sultan, Amir Badshah, Aziz

Muhammad, Khalid Rauf, Gowhar Ali. Development, in Vitro Characterization and

Comparative Pharmacokinetic Evaluation of Novel Controlled Release Matrix

Tablets vs. Conventional Tablets of Olanzapine in Healthy Human Volunteers.

Journal of the Chemical Society of Pakistan (2013) 35:947-954. (IF: 0.345)

33. Nasir Ullah, Nazar Ul Islam, Gowhar Ali, Fazal Subhan, Ikhtiar Khan. Bioisosteric

synthesis of nitrogen containing derivatives of salicyl alcohol, their in vivo

pharmacological studies with molecular modeling. Medicinal Chemistry Research

(2013) 22:4677–4684. (IF: 1.402)

34. Khalid Rauf, Fazal Subhan, AM Al-Othman, I Khan, A Zarrelli, MR Shah.

Preclinical Profile of Bacopasides From Bacopa monnieri (BM) As An Emerging

Class of Therapeutics for Management of Chronic Pains. Current Medicinal

Chemistry (2013) 20:1028-1037. (IF: 3.853)

35. Khalid Rauf, Fazal Subhan, Muzaffar Abbas, Syed Mobasher Ali, Gowhar Ali,

Muhammad Ashfaq, Ghulam Abbas. Inhibitory Effect of Bacopasides on

Spontaneous Morphine Withdrawal Induced Depression in Mice. Phytotherapy

Research (2013). (IF: 2.660)

36. Khalid Rauf, Fazal Subhan, Ghulam Abbas, Gowhar Ali, Syed Mobasher Ali Abid,

Usman Arshad, Muhammad Junaid Hassan Sharif. Bacopa monnieri inhibits

locomotor hyperactivity induced by morphine without altering noradrenaline.

Pharmacologyonline (2013) 1:172-181.

37. Munasib Khan, Fazal Subhan, Arif-ullah Khan, Muzaffar Abbas, Gowhar Ali,

Khalid Rauf, Anwarul Hassan Gilani. Nature cures nature: Hypericum perforatum

attenuates physical withdrawal signs in opium dependent rats. Pharmaceutical

Biology (2013):1-5. (IF: 1.241)

38. Gowhar Ali, Fazal Subhan, Abdul Wadood, Ajmal Khan, Nasir Ullah, Nazar Ul

Islam, Ikhtiar Khan. Pharmacological evaluation, molecular docking and dynamics

simulation studies of salicyl alcohol nitrogen containing derivatives. African Journal

of Pharmacy and Pharmacology (2013) 7:585-596. (IF: 0.8)

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39. Gowhar Ali, Fazal Subhan, Nazar Ul Islam, Nasir Ullah, Muhammad Shahid, Sami

Ullah, Ihsan Ullah, Rehmat Shah, Ikhtiar Khan, Robert DE Sewell, Ghulam Abbas.

Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of

salicyl alcohol and aspirin in rats: biochemical and histological study. Archives of

Pharmacal Research (2013):1-11. (IF: 2.046)

40. Gowhar Ali, Fazal Subhan, Nazar Ul Islam, Nasir Ullah, Robert D. E Sewell,

Muhammad Shahid, Ikhtiar Khan. Synthetically modified bioisosteres of salicyl

alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and

histological correlates. Naunyn-Schmiedeberg's Archives of Pharmacology (2013):1-

10. (IF: 2.471)

41. Gowhar Ali, Fazal Subhan, Nazar Ul Islam, Inamullah Khan, Khalid Rauf, Sami

Ullah, Muzaffar Abbas, Abdur Rauf. Input of Isosteric and Bioisosteric Approach

in Drug Design. Journal of the Chemical Society of Pakistan (2013). (IF: 0.345)

42. Amir Badshah, Fazal Subhan, NH Shah, NI Bukhari, M Saeed, KU Shah. Once

daily controlled release matrix tablet of Prochlorperazine maleate: influence of

Ethocel® and/or Methocel® on in vitro drug release and bioavailability. Drug

Development and Industrial Pharmacy (2012 ) 38:190-199. (IF: 2.101)

43. Ihsan Ullah, Fazal Subhan, Khalid Rauf, Amir Badshah, Gowhar Ali. Role of

gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon.

African Journal of Pharmacy and Pharmacology (2012) 6:2592-2599. (IF: 0.8)

44. Rehmat Shah, Fazal Subhan, Khalid Rauf, Sami Ullah, Gowhar Ali. Case report

study of urea cycle disorder from North-west part of Pakistan. Pharmacologyonline

(2012) 1:1-5.

45. Khalid Rauf, Fazal Subhan, Muzaffar Abbas, Ikram ul Haq, Gowhar Ali,

Muhammad Ayaz. Effect of acute and sub chronic use of Bacopa monnieri on

dopamine and serotonin turnover in mice whole brain. African Journal of Pharmacy

and Pharmacology (2012) 6:2767-2774. (IF: 0.8)

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46. Khalid Rauf, Fazal Subhan, R.D.E. Sewell. A bacoside containing Bacopa monnieri

extract reduces both morphine hyperactivity plus the elevated striatal dopamine and

serotonin turnover. Phytotherapy Research (2012) 26:758-763. (IF: 2.660)

47. Khalid Rauf, Fazal Subhan, Muzaffar Abbas, Amir Badshah, Ihsan Ullah, Sami

Ullah. Effect of bacopasides on acquisition and expression of morphine tolerance.

Phytomedicine (2011) 18:836-842. (IF: 3.126)

48. Zahid Nazar, Javaid Akhtar, Saeed Farooq, Muhammad Irfan, Rubina Shaheen,

Muneer Ahmad, Naila Riaz Awan, Zia Ahmad, Fazal Subhan, Athar Mahmood

Safi. Adverse side effects of lithium and fasting (Ramadan). Journal of Postgraduate

Medical Institute (Peshawar-Pakistan) (2011) 23.

49. Arif-ullah Khan, Anwarul-Hassan Gilani, Munasib Khan, Fazal Subhan.

Pharmacological explanation for medicinal use of St. John's wort in the hypo-

motility disorder of gut. Latin American Journal of Pharmacy (2011) 580-583. (IF:

0.372)

50. Amir Badshah, Fazal Subhan, Khalid Rauf, Nadeem Irfan Bukhari, Kifayatullah

Shah, Samiullah Khan, Zia Ahmed, Ihsanullah Khan. Development of controlled-

release matrix tablet of risperidone: influence of methocel®-and ethocel®-based

novel polymeric blend on in vitro drug release and bioavailability. AAPS

PharmSciTech (2011) 12:525-533. (IF: 1.641)

51. Muzaffar Abbas, Fazal Subhan, Khalid Rauf, Munasib Khan, Syed Nadeem-ul-

Hassan Mohani. The involvement of biogenic amines in the antidepressant effect of

Bacopa monnieri. Pharmacologyonline (2011) 1:112-123.

52. Muzaffar Abbas, Fazal Subhan, N. Mohani, Khalid Rauf, G. Ali, M. Khan. The

involvement of opioidergic mechanisms in the activity of Bacopa monnieri extract

and its toxicological studies. African Journal of Pharmacy and Pharmacology

(2011) 5:1120-1124. (IF: 0.8)

53. Fazal Subhan, Nasiara Karim, Anwarul Hassan Gilani, Robert DE Sewell.

Terpenoid content of Valeriana wallichii extracts and antidepressant‐like response

profiles. Phytotherapy Research (2010) 24:686-691. (IF: 2.660)

17

54. Fazal Subhan, Muzaffar Abbas, Khalid Rauf, Abdul Baseer. Anti GIT motility,

toxicological and phytochemical studies on Bacopa monnieri. Pharmacologyonline

(2010) 3:937-950.

55. Fazal Subhan, Muzaffar Abbas, Khalid Rauf, Mohammad Arfan, Robert DE

Sewell, Gowhar Ali. The role of opioidergic mechanism in the activity of Bacopa

monnieri extract against tonic and acute phasic pain modalities. Pharmacologyonline

(2010) 3:903-914.

56. Arifullah Khan, Munasib Khan, Fazal Subhan, Anwarul Hassan Gilani.

Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum

oblongifolium–possible mechanism of action. Phytotherapy Research (2010)

24:1027-1032. (IF: 2.660)

57. Saeed Farooq, Zahid Nazar, Javed Akhter, Mohammad Irafn, Fazal Subhan, Zia

Ahmed, Ijaz Hassan Khatak, Farooq Naeem. Effect of fasting during Ramadan on

serum lithium level and mental state in bipolar affective disorder. International

Clinical Psychopharmacology (2010) 25:323-327. (IF: 2.456)

58. Amir Badshah, Fazal Subhan, Khalid Rauf. Controlled release matrix tablets of

olanzapine: influence of polymers on the in vitro release and bioavailability. AAPS

PharmSciTech (2010) 11:1397-1404. (IF: 1.641)

59. Fazal Subhan, Nematullah Khan, R.D.E Sewell. Adulterant profile of illicit street

heroin and reduction of its precipitated physical dependence withdrawal syndrome

by extracts of St John's wort (Hypericum perforatum). Phytotherapy Research

(2009) 23:564-571. (IF: 2.660)

60. Fazal Subhan. Anti-inflammatory activity of methanolic and aqueous extracts of

Valeriana wallichii rhizome. Presented at the 1st National symposium, old plants,

new remedies (2008) Department of Pharmacy, University of Malakand.

61. Fazal Subhan. Antidepressant and phytochemical studies on Bacopa monniera.

Presented at the 1st National symposium, old plants, new remedies, (2008)

Department of Pharmacy, University of Malakand.

18

62. Fazal Subhan. Effect of Hydroethanolic extracts of Hypericum perforatum on

Naloxone induced opium withdrawal syndrome in rats. Presented at the 1st National

symposium, old plants, new remedies, (2008) Department of Pharmacy, University

of Malakand.

63. Fazal Subhan, Munasib Khan, Mohammad Ibrar, Arifullah Khan, AH Gilani.

Antagonism of antinociceptive effect of hydro-ethanolic extract of Hypericum

perforatum Linn. by a non selective opioid receptor antagonist, naloxone. Pakistan

Journal of Biological Sciences (2007) 10:792.

64. Fazal Subhan, Nasiara Karim, Muhammad Ibrar. Antiinflammatory activity of

methanolic and aqueous extracts of Valeriana wallichii DC rhizome. Pakistan

Journal of Plant Sciences (2007) 13:103-108.

65. Mohammad Ibrar, Fazal Subhan, Farrukh Hussain. Post Harvest Treatment of

Medicinal Plants using simple facilities. Peshawar University Teacher Association

Journal (2005) 12:59-66.

66. Anwar H Gilani, Arif-ullah Khan, Qaiser Jabeen, Fazal Subhan, Rukhsana Ghafar.

Antispasmodic and blood pressure lowering effects of Valeriana wallichii are

mediated through K+ channel activation. Journal of Ethnopharmacology (2005)

100:347-352. (IF: 2.998)

67. Anwarul Hassan Gilani, Arifullah Khan, Fazal Subhan, Munasib Khan.

Antispasmodic and bronchodilator activities of St John's wort are putatively

mediated through dual inhibition of calcium influx and phosphodiesterase.

Fundamental and Clinical Pharmacology (2005) 19:695-705. (IF: 2.12)

68. Fazal Subhan, Munasib Khan, Ibrar. Mohammad, Nazar Ul Islam, Anwarul Hassan

Gilani, Arifullah Khan. Effect of Aqueous–Ethanolic extract of Hypericum

perforatum on naloxone precipitated opium withdrawal syndrome. Presented at the

2nd International conference on traditional medicine & Materia Medica, (2004)

Tehran, Iran.

19

69. Mohammad Ibrar, Fazal Subhan, Amir Zada Khan. Medicinal plants cultivation,

collection and preservation. Peshawar University Teacher Association Journal

(2003) 10:49-56.

70. Fazal Subhan, Abdul Matin Khan, Ahmad Yar Sial, Muhammad Azam Zia, Haroon

ur Rashid. Drug dependence-neurotransmitter systems and paradigm for assessment.

Pakistan Armed forces Medical Journal (2002) 52:76-83.

71. Fazal Subhan, Amir Zada Khan, Mohammad Saeed, I Khan. Effect of chronic

treatment of antidepressants on dopamine and its metabolites in the brain areas of

nucleus accumbens and striatum: An animal study. Scientific Khyber (2002) 15.

72. Fazal Subhan, Mohammad Ibrar, Amir Zada Khan, M Arfan, G Nawab. Effect of

Ajuga bracteosa on serum level of triiodothyronin (T3) and thyroxin (T4) in rabbits.

Journal of Science and Technology (2002) 26:7-9.

73. Fazal Subhan. Rewarding properties of serotonin selective reuptake inhibitor,

paroxetine: Behavioural and biochemical correlates. Peshawar University Teacher

Association Journal (2002) 9:27-33.

74. Ikhtiar Khan, Gul Nawab, Ijaz Ahmad, Fazal Subhan. Thyroid hormones level in

healthy population of N.W.F.P. Scientific Khyber (2002) 15:9-16.

75. Abdul Subhan Ijaz, Fazal Subhan, Nazar ul Islam, Saeed Ahmad, Arif Ali Rajer.

Synthesis of pharmacologically active isatin derivatives. Scientific Khyber (2002)

15:9-16.

76. Fazal Subhan, David M Pache, Robert DE Sewell. CCKb receptor antagonism

attenuates negative motivational properties and somatic physical signs of morphine

withdrawal. Pharmacology Reviews and Communications (2000) 11:27-37.

77. Fazal Subhan, David M Pache, Robert DE Sewell. Potentiation of opioid-induced

conditioned place preference by the selective serotonin reuptake inhibitor fluoxetine.

European Journal of Pharmacology (2000) 390:137-143. (IF: 2.532)

20

78. Fazal Subhan, Paul N Deslandes, David M Pache, Robert DE Sewell. Do

antidepressants affect motivation in conditioned place preference? European Journal

of Pharmacology (2000) 408:257-263. (IF: 2.532)

79. Muhammad Saeed, Anwar ul Hassan Gilani, Zafar Iqbal, Fazal Subhan, Jamshid

Ali Khan. Screening of some 4-acetyl-4-phenylpiprridine derivatives for their

effects on blood pressure and smooth muscle contraction. Scientific Khyber (2000)

13:59-62.

80. Daniel M Hutcheson, Fazal Subhan, David M Pache, Rafael Maldonado, Marie-

Claudé Fournié-Zaluski, Bernard P Roques, Robert DE Sewell. Analgesic doses of

the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative

stimulus properties. European Journal of Pharmacology (2000) 401:197-204. (IF:

2.532)

81. Fazal Subhan, D.M Pache, P.S.J Spencer, R.D.E Sewell. Effect of the selective

serotonin reuptake inhibitor, fluoxetine, on the rewarding properties of opioids as

assessed by conditioned place preference. Journal of Pharmacy and Pharmacology

(1999) 51:(Supp) 14.

82. Fazal Subhan, DM Pache, RDE Sewell. CCKB receptor antagonism attenuates

naloxone‐induced morphine withdrawal conditioned place aversion and escape

behaviour. Journal of Pharmacy and Pharmacology (1998) 50:205-205.

83. Fazal Subhan, Nazar ul Islam, Azmath Rasheed, Abdul Subhan Ijaz, Mehboob

Alam. Biochemical and histological effects induced by the antiviral drug, N-

methylisatin-3-thio semicarbazone in rabbits. Journal of Science and Technology

University of Peshawar (1998) 22:17-21.

84. Fazal Subhan, R.D.E. Sewell. Effect of rewarding doses of morphine or fluoxetine

on the striatal and nucleus accumbens levels of dopamine and its metabolites: A

comparative study. Pakistan Journal of Pharmacy (1997) 10:23-34.

85. Fazal Subhan, D.M Hutcheson, D.M Pache, R.D.E Sewell. RB 1000 and the CCKB

antagonist, CI 988 fail to affect a morphine interoceptive cue. Psychopharmacology

(1997):(Supp) 11, 13.

21

86. Fazal Subhan, Azmat Rasheed, Mohammad Arfan. Effect of Ajuga bracteosa on

some of the biochemical parameters in rabbits. Hamdard Medicus (1996)

XXXIX:84-89.

87. A Rasheed, M Riaz, Fazal Subhan, S Javid. Blood glucose level and body

temperature after concomitant administration of chloramphenicol and aspirin in

rabbits. Pakistan Journal of Zoology (1992) 24:360-362. (IF: 0.404)

88. A Rasheed, M Alam, Fazal Subhan. Pharmacokinetics of N-methylisatin-3-

thiosemicarbazone in rabbit. Pakistan Veterinary Journal (1987) 7. (IF: 1.392)

22