DNA nanotechnology: Geometric sorting boards
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Transcript of DNA nanotechnology: Geometric sorting boards
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DNA nanotechnology: Geometric sorting
boards
Speaker: Zong-Han LiInstructor: Kun-Mao Chao
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David W. Grainger Nature Nanotechnology 4, 543 - 544 (2009)
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DNA Origami Surface patterning with DNA tiles DNA tiny chips Geometrical self-assembly
Outline
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A: single-stranded DNA and staple strands.
B: Design of a self-assembled DNA origami structure and geometry of the incorporated double-stranded DNAs.
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DNA Origami
Endo, M. and Sugiyama, H. 2011. Recent Progress in DNA Origami Technology. Current Protocols in Nucleic Acid Chemistry. 45:12.8.1–12.8.19.
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a:Nanoscale DNA tiles
b:DNA tiles decorated with different functional reagents are used to create a variety of functional devices from a mixed solution of tiles.
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Surface patterning with DNA tiles.
David W. GraingerNature Nanotechnology 4, 543 - 544 (2009)doi:10.1038/nnano.2009.249
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DNA tiny chips
Tiny, triangular DNA structures self-assemble on silicon.Credit: IBM
R. J. Kershner et al Nature Nanotechnology 4, 557 - 561 (2009)
DNA Origami for Faster, Smaller Computer Chips
IBM suggests that it could take up to 10 years to test and refine the process for manufacturing.
6nm
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Geometrical self-assembly
DNA nanotechnology: Geometrical self-assemblyAndrew J. TurberfieldNature Chemistry 3, 580–581 (2011) doi:10.1038/nchem.1097
Attractive interactions between DNA origami tiles are coded in their complementary shaped edges, recapitulating the binding of complementary sequences of bases to form a DNA double helix.
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Thanks for your attention