Division of GERIATRIC MEDICINEPittsburgh, PA 15261 Department of Medicine School of Medicine. ......

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Division of GERIATRIC MEDICINE 2019 ANNUAL REPORT

Transcript of Division of GERIATRIC MEDICINEPittsburgh, PA 15261 Department of Medicine School of Medicine. ......

Division of

Neil Resnick, MDDivision Chief

GERIATRIC MEDICINE

2019

ANNUAL REPORT

1218 Scaife Hall3550 Terrace StreetPittsburgh, PA 15261

D e p a r t m e nt of Me d i c i n eSchool o f Medic ine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

TABLE OF CONTENTSMessage from the Chief 1

Faculty Listing 3

Clinical Activities 5

Clinical Quality Improvements 7

Clinical Locations 11

Research and Other Scholarly Activities 13

Teaching Activities 30

Three-Year Bibliography 34

Acknowledgments 66

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Lisa Gundel, MPPMDivision Administrator, Geriatric Medicine

Educationally, we again filled our fellowship and T32 slots with excellent trainees, including two subspecialty fellows graduating, one in geriatric palliative care and one in geriatric cardiology. Another fellow completed her T32 masters degree in Medical Education, during which she created and evaluated an Interprofessional Dedicated Education Unit (IPDEU), which is now embedded on UPMC Presbyterian’s Neurosurgery ward. Substantial enhancements occurred at the residency level, and we also expanded and enhanced our required interdisciplinary medical school training course which now also comprises >200 students from 10 healthcare disciplines. The course is led by Dr. Rollin Wright who also published her innovative hospitalist and dementia teaching modules in Annals of Internal Medicine Online. Finally, our Pepper Center provided a university-wide leadership training program for junior faculty members in aging.

In research, we continued our collaboration with Dr. Toren Finkel and the Aging Institute, expanded our NIH-funded Center of Excellence in Long-Term Care Research, renewed our T32 in Gerontology, and submitted the renewal of our NIH Center of Excellence in Aging (Pepper). We also recruited 2 new faculty (Drs. Makaroun, Rizzo). Finally, faculty members won research awards and continued to serve on editorial boards as well as advisory boards of NIH, CDC, ACIP, AGS, and NOF, and as consultants to CMS, HEDIS and NQF.

The Division of Geriatric Medicine’s mission is to enhance the health of older adults by providing superb clinical care, by training others to do the same, and by conducting research to ensure that tomorrow’s care is better than today’s.

Given the national declines in funding, we are focusing more than ever on innovation as our primary strategy for achieving our goals. Our efforts in FY19 reflect this vision. Clinically, the Division grew our practice by 5% and integrated our ambulatory sites. We launched new programs in Chronic Care Management and Transitional Care Management, utilizing Medicare funding to create the infrastructure needed to improve care of our patients with multiple comorbidity. We enhanced our shared savings program with UPMC’s Health Plan: we added patients, exceeded quality benchmarks, and saved >$550,000.

Division of

“The Division of Geriatric Medicine’s mission is to enhance the health of older adults by providing superb clinical care, by training others to do the same, and by conducting research to ensure that tomorrow’s care is better than today’s.”

GERIATRIC MEDICINE

GERIATRIC MEDICINE Fast Facts

32academic faculty

members

$5.5milin research funding

#12among geriatric

programs in the U.S.- U.S. News and World Report

Neil M. Resnick, MDChief, Division of Geriatric MedicineThomas Detre Professor of MedicineAssociate Director, Aging InstituteDirector, Hartford Center of Excellence in Geriatrics

1

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Lisa Gundel, MPPMDivision Administrator, Geriatric Medicine

Educationally, we again filled our fellowship and T32 slots with excellent trainees, including two subspecialty fellows graduating, one in geriatric palliative care and one in geriatric cardiology. Another fellow completed her T32 masters degree in Medical Education, during which she created and evaluated an Interprofessional Dedicated Education Unit (IPDEU), which is now embedded on UPMC Presbyterian’s Neurosurgery ward. Substantial enhancements occurred at the residency level, and we also expanded and enhanced our required interdisciplinary medical school training course which now also comprises >200 students from 10 healthcare disciplines. The course is led by Dr. Rollin Wright who also published her innovative hospitalist and dementia teaching modules in Annals of Internal Medicine Online. Finally, our Pepper Center provided a university-wide leadership training program for junior faculty members in aging.

In research, we continued our collaboration with Dr. Toren Finkel and the Aging Institute, expanded our NIH-funded Center of Excellence in Long-Term Care Research, renewed our T32 in Gerontology, and submitted the renewal of our NIH Center of Excellence in Aging (Pepper). We also recruited 2 new faculty (Drs. Makaroun, Rizzo). Finally, faculty members won research awards and continued to serve on editorial boards as well as advisory boards of NIH, CDC, ACIP, AGS, and NOF, and as consultants to CMS, HEDIS and NQF.

The Division of Geriatric Medicine’s mission is to enhance the health of older adults by providing superb clinical care, by training others to do the same, and by conducting research to ensure that tomorrow’s care is better than today’s.

Given the national declines in funding, we are focusing more than ever on innovation as our primary strategy for achieving our goals. Our efforts in FY19 reflect this vision. Clinically, the Division grew our practice by 5% and integrated our ambulatory sites. We launched new programs in Chronic Care Management and Transitional Care Management, utilizing Medicare funding to create the infrastructure needed to improve care of our patients with multiple comorbidity. We enhanced our shared savings program with UPMC’s Health Plan: we added patients, exceeded quality benchmarks, and saved >$550,000.

Division of

“The Division of Geriatric Medicine’s mission is to enhance the health of older adults by providing superb clinical care, by training others to do the same, and by conducting research to ensure that tomorrow’s care is better than today’s.”

GERIATRIC MEDICINE

GERIATRIC MEDICINE Fast Facts

32academic faculty

members

$5.5milin research funding

#12among geriatric

programs in the U.S.- U.S. News and World Report

Neil M. Resnick, MDChief, Division of Geriatric MedicineThomas Detre Professor of MedicineAssociate Director, Aging InstituteDirector, Hartford Center of Excellence in Geriatrics

2

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

FACULTYNeil M. Resnick, MDChief, Division of Geriatric MedicineThomas Detre Professor of MedicineAssociate Director, Aging InstituteDirector, Hartford Center of Excellence in Geriatrics

Namita S. Ahuja-Yende, MDClinical Assistant Professor of MedicineMedical Director, UPMC Heritage Shadyside Nursing CenterMedical Director, UPMC Health Plan I-SNP Program

Becky D. Clarkson, PhDResearch Instructor in Medicine

Daniel E. Forman, MDProfessor of MedicineChair, Section of Geriatric Cardiology

Amelia S. Gennari, MDAssociate Professor of Medicine

Susan L. Greenspan, MDProfessor of MedicineDirector, Osteoporosis Prevention and Treatment Center

Aditi U. Gurkar, PhDAssistant Professor of Medicine

Steven M. Handler, MD, PhDAssociate Professor of Medicine, Biomedical Informatics, and Clinical & Translational ResearchAssociate Professor of RAND-University of Pittsburgh Health Institute (RUPHI)Core Faculty, Center for Critical Care NephrologyDirector of Geriatric Telemedicine ProgramsChief Medical Informatics Officer (CMIO), UPMC Community Provider Services

Joseph T. Hanlon, PharmD, MSProfessor of Medicine

Shuja Hassan, MDAssistant Professor of MedicineMedical Director, UPMC Canterbury Place

Mary P. Kotlarczyk, PhDResearch Assistant Professor of MedicineAssociate Director, Osteoporosis Prevention and Treatment Center

Elizabeth Metrovich, DOClinical Assistant Professor of Medicine

David A. Nace, MD, MPHAssociate Professor of MedicineDirector of Long Term Care & Flu Programs, University of PittsburghInstitute on Aging, Medical Director

Neelesh K. Nadkarni, MD, PhDAssistant Professor of Medicine

John Naumovski, MDClinical Assistant Professor of Medicine

Anne B. Newman, MD, MPHProfessor of Medicine, Secondary Appointment

Elizabeth A. O'Keefe, MDAssociate Professor of MedicineAssociate Director, Geriatrics Fellowship program

David A. Pasquale, DOClinical Assistant Professor of Medicine

Subashan Perera, PhDProfessor of Medicine and BiostatisticsCore Co-Leader & Senior Statistician, Data Management and Analysis Core of the Pittsburgh Claude D. Pepper Older Americans Independence Center

Beth Porter, MDClinical Assistant Professor of Medicine

Sangeeta Rana, MD, MPHAssistant Professor of Medicine

Eric G. Rodriguez, MD, MPHAssociate Professor of Medicine

Michelle I. Rossi, MD, MPHAssociate Professor of Medicine and EpidemiologyAssociate Director of Clinical Care Activities, Geriatric ResearchEducation and Clinical Center (GRECC) VA Pittsburgh Healthcare SystemDirector, Geriatric Evaluation and Management (GEM) Clinic, VA Pittsburgh Healthcare System

Fred H. Rubin, MDProfessor of MedicineChairman, Department of Medicine at UPMC Shadyside

Karen E. Glasser Scandrett, MD, MPHAssistant Professor of MedicineDirector, Geriatric Fellowship Program

Leslie P. Scheunemann, MD, MPHAssistant Professor of Medicine

Stasa D. Tadic, MD, MSAssociate Professor of MedicineAcademic Chief, Geriatric Medicine, UPMC MercyPhysician Leader, Supportive Services, UPMC Health Plan

Adele L. Towers, MD, MPHAssociate Professor of Medicine & PsychiatrySenior Clinical Advisor, UPMC EnterprisesDirector of Risk Adjustment, UPMC Enterprises

Shachi Tyagi, MD, MSAssistant Professor of Medicine

Adrian Visoiu, MDClinical Associate Professor of Medicine

Keisha Ward, MDClinical Assistant Professor of Medicine

Debra K. Weiner, MDProfessor of MedicineAssociate Director, Geriatric Fellowship Program

Rollin M. Wright, MD, MA, MPHAssistant Professor of MedicineChair of Education Committee, Division of Geriatric Medicine

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

FACULTYNeil M. Resnick, MDChief, Division of Geriatric MedicineThomas Detre Professor of MedicineAssociate Director, Aging InstituteDirector, Hartford Center of Excellence in Geriatrics

Namita S. Ahuja-Yende, MDClinical Assistant Professor of MedicineMedical Director, UPMC Heritage Shadyside Nursing CenterMedical Director, UPMC Health Plan I-SNP Program

Becky D. Clarkson, PhDResearch Instructor in Medicine

Daniel E. Forman, MDProfessor of MedicineChair, Section of Geriatric Cardiology

Amelia S. Gennari, MDAssociate Professor of Medicine

Susan L. Greenspan, MDProfessor of MedicineDirector, Osteoporosis Prevention and Treatment Center

Aditi U. Gurkar, PhDAssistant Professor of Medicine

Steven M. Handler, MD, PhDAssociate Professor of Medicine, Biomedical Informatics, and Clinical & Translational ResearchAssociate Professor of RAND-University of Pittsburgh Health Institute (RUPHI)Core Faculty, Center for Critical Care NephrologyDirector of Geriatric Telemedicine ProgramsChief Medical Informatics Officer (CMIO), UPMC Community Provider Services

Joseph T. Hanlon, PharmD, MSProfessor of Medicine

Shuja Hassan, MDAssistant Professor of MedicineMedical Director, UPMC Canterbury Place

Mary P. Kotlarczyk, PhDResearch Assistant Professor of MedicineAssociate Director, Osteoporosis Prevention and Treatment Center

Elizabeth Metrovich, DOClinical Assistant Professor of Medicine

David A. Nace, MD, MPHAssociate Professor of MedicineDirector of Long Term Care & Flu Programs, University of PittsburghInstitute on Aging, Medical Director

Neelesh K. Nadkarni, MD, PhDAssistant Professor of Medicine

John Naumovski, MDClinical Assistant Professor of Medicine

Anne B. Newman, MD, MPHProfessor of Medicine, Secondary Appointment

Elizabeth A. O'Keefe, MDAssociate Professor of MedicineAssociate Director, Geriatrics Fellowship program

David A. Pasquale, DOClinical Assistant Professor of Medicine

Subashan Perera, PhDProfessor of Medicine and BiostatisticsCore Co-Leader & Senior Statistician, Data Management and Analysis Core of the Pittsburgh Claude D. Pepper Older Americans Independence Center

Beth Porter, MDClinical Assistant Professor of Medicine

Sangeeta Rana, MD, MPHAssistant Professor of Medicine

Eric G. Rodriguez, MD, MPHAssociate Professor of Medicine

Michelle I. Rossi, MD, MPHAssociate Professor of Medicine and EpidemiologyAssociate Director of Clinical Care Activities, Geriatric ResearchEducation and Clinical Center (GRECC) VA Pittsburgh Healthcare SystemDirector, Geriatric Evaluation and Management (GEM) Clinic, VA Pittsburgh Healthcare System

Fred H. Rubin, MDProfessor of MedicineChairman, Department of Medicine at UPMC Shadyside

Karen E. Glasser Scandrett, MD, MPHAssistant Professor of MedicineDirector, Geriatric Fellowship Program

Leslie P. Scheunemann, MD, MPHAssistant Professor of Medicine

Stasa D. Tadic, MD, MSAssociate Professor of MedicineAcademic Chief, Geriatric Medicine, UPMC MercyPhysician Leader, Supportive Services, UPMC Health Plan

Adele L. Towers, MD, MPHAssociate Professor of Medicine & PsychiatrySenior Clinical Advisor, UPMC EnterprisesDirector of Risk Adjustment, UPMC Enterprises

Shachi Tyagi, MD, MSAssistant Professor of Medicine

Adrian Visoiu, MDClinical Associate Professor of Medicine

Keisha Ward, MDClinical Assistant Professor of Medicine

Debra K. Weiner, MDProfessor of MedicineAssociate Director, Geriatric Fellowship Program

Rollin M. Wright, MD, MA, MPHAssistant Professor of MedicineChair of Education Committee, Division of Geriatric Medicine

4

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

CLINICAL ACTIVITIES

We focus on prevention and management of the complex medical and psychosocial problems that afflict older adults. Even excluding our VA efforts, we are responsible for thousands of ambulatory visits and hospital discharges, and nearly 15,000 long term care visits at 13 different facilities.In FY19, we also built on the success of our telemedicine efforts,

which had previously reduced unplanned nursing home transfers, contributed to our two successful $20 million CMS Innovation Center grants, and led UPMC Enterprises in 2017 to create Curavi HealthTM: in FY19, Curavi acquired a New York telemedicine company and it now serves more than 100 nursing homes in 14 states. To further help UPMC reduce readmissions, we expanded our Geriatric Trauma Service, which provides a proactive approach to >2000 older trauma patients admitted annually to UPMC Presbyterian (PUH); propensity analyses showed that we cut readmissions by 42%. Our delirium prevention (HELP) program at UPMC Shadyside cut readmissions hospital-wide by 17% (JAGS 2018). With radiology, we devised a new program to reinsert PEG tubes in NH patients and avoid ED visits. We initiated a novel transition service for older TAVR and heart failure patients discharged to NHs. With orthopedics, we expanded our Fracture Liaison Service (JBMR 2017) to ensure that, in addition to fracture repair, older patients receive appropriate therapy for osteoporosis; the service is now the model for the National Osteoporosis Foundation, and we are now working with UPMC Health Plan to scale it. We also grew two novel ambulatory geriatric subspecialty services: one in geriatric cardiology and another in geriatric chronic pain, and we partnered with nursing on two Beckwith awards to create delirium prevention rooms, both at UPMC PUH and Mercy hospitals. In FY19, we were asked to help UPMC Mercy create a Geriatric Center of Excellence. In just a few months, and benefiting from our previous efforts at UPMC Magee, Mercy was able to gain certification as a level 3 Geriatric ED as well as a NICHE site, and is committed to staffing every ward with at least one geriatric nurse specialist. Finally, we just recruited a new Clinical Chief and filled an open clinician position to start in December 2019. And for 2019, U.S. News and World Report ranked us #12 in Geriatrics.

In addition to our clinical volume, which is large for an academic geriatric division, our effort comprises several special features:

• Physician Excellence: 15 of our faculty are now in America’s Top Docs and/or Best Doctors inAmerica. And, of the 73 physicians (of >3000) to receive UPMC’s Award of Excellence in 2019, 4

T h e D i v i s i o nd e v e l o p e d t h e

Pat ient -CenteredMedica l Homespec ifica l ly for

ger iatr ic pat ients

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

were from our faculty.• Vertically-Integrated Care Across the Entire Health Care Spectrum• Chronic Care Management (CCM): We were the first NCQA-certified Patient Centered Medical

Home designed specifically for geriatric patients (Gennari et al., Cleveland Clin J Med, 2012;79:359-66). We have now augmented it by creating a program to manage patients with multiple chronic conditions in compliance with the new CCM billing code. The program is based on patient goals, involves all members of the care team, and is designed to anticipate and avert problems in our most complicated patients.

• Group Visits: For >15 years, Dr. Towers has led one of the first such programs in an academic center.

• Integrated Geriatric Subspecialty Care: Consultative care is provided by fellowship-trained geriatricians, many of whom have additional training in cardiology, chronic pain, gait/mobility, sarcopenia, falls, osteoporosis, pulmonary/critical care, insomnia, incontinence, rheumatology, depression, dementia, audiology, or palliative care. DXA testing is provided by a dually-trained geriatric endocrinologist (Dr. Greenspan).

• Geriatric Pharmacists and Social Workers: Our geriatric pharmacists review medications, provide education, and counsel patients (cf: Gavini, Gennari, Ruby, Consult Pharm, 2015;30:153). This service is especially important for patients recently discharged from the hospital or SNF and for those on warfarin. Our social workers serve both inpatients and outpatients. They help with care transitions, family conferences, and end of life/palliative care discussions. They also provide resources to address care deficits and financial issues, and they educate patients and families on a variety of topics including dementia and insurance coverage.

• Emergency Care: Both UPMC Magee and UPMC Mercy now screen for delirium in every older patient in the Emergency Room, and pharmacists review the medications of every patient with a positive screening test.

• Hospitalist and Consult Services: At Shadyside, we staff a geriatrics hospitalist service and a consult service.

• HELP Program: Based on Dr. Inouye’s program and led by Drs. Rubin and Hassan, this service prevents delirium and has saved >$7 million/year since 2008 at UPMC Shadyside (Rubin, JAGS2011 and JAGS 2018)

• UPMC Presbyterian (PUH) Geriatric Trauma Service: Dr. Scandrett initiated this service in 2016 to meet the needs of >2000 older patients admitted annually to our Level 1 trauma hospital. Readmissions were cut 42%.

• Fracture Liaison Service (UPMC PUH-Shadyside): Dr. Greenspan created this national model to ensure that, in addition to surgical repair, those with a fracture are evaluated and treated for osteoporosis (JBMR 2017).

• Telemedicine Service for all of our institutionalized residents, both after hours and on weekends.• Transitional Care Management/Readmission Prevention: Each of our patients is contacted within

48 hours of hospital discharge to review their progress, medications, unanticipated problems, and plans for medical follow-up. Uniquely, we have a similar process for our patients discharged from SNFs. In addition, for each readmission, the clinicians involved (PCP, hospitalist, NH physician, pharmacist, social worker, and/or home care) strive to identify interventions to prevent future readmissions, both at the patient and the system level.

• Advanced Heart Failure: A new unit, created at UPMC’s Canterbury SNF, is led by Drs. Hassan and

NCQA-certified1st

5

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

CLINICAL CARE

We focus on prevention and management of the complex medical and psychosocial problems that afflict older adults. Even excluding our VA efforts, we are responsible for thousands of ambulatory visits and hospital discharges, and nearly 15,000 long term care visits at 13 different facilities.In FY19, we also built on the success of our telemedicine efforts,

which had previously reduced unplanned nursing home transfers, contributed to our two successful $20 million CMS Innovation Center grants, and led UPMC Enterprises in 2017 to create Curavi HealthTM: in FY19, Curavi acquired a New York telemedicine company and it now serves more than 100 nursing homes in 14 states. To further help UPMC reduce readmissions, we expanded our Geriatric Trauma Service, which provides a proactive approach to >2000 older trauma patients admitted annually to UPMC Presbyterian (PUH); propensity analyses showed that we cut readmissions by 42%. Our delirium prevention (HELP) program at UPMC Shadyside cut readmissions hospital-wide by 17% (JAGS 2018). With radiology, we devised a new program to reinsert PEG tubes in NH patients and avoid ED visits. We initiated a novel transition service for older TAVR and heart failure patients discharged to NHs. With orthopedics, we expanded our Fracture Liaison Service (JBMR 2017) to ensure that, in addition to fracture repair, older patients receive appropriate therapy for osteoporosis; the service is now the model for the National Osteoporosis Foundation, and we are now working with UPMC Health Plan to scale it. We also grew two novel ambulatory geriatric subspecialty services: one in geriatric cardiology and another in geriatric chronic pain, and we partnered with nursing on two Beckwith awards to create delirium prevention rooms, both at UPMC PUH and Mercy hospitals. In FY19, we were asked to help UPMC Mercy create a Geriatric Center of Excellence. In just a few months, and benefiting from our previous efforts at UPMC Magee, Mercy was able to gain certification as a level 3 Geriatric ED as well as a NICHE site, and is committed to staffing every ward with at least one geriatric nurse specialist. Finally, we just recruited a new Clinical Chief and filled an open clinician position to start in December 2019. And for 2019, U.S. News and World Report ranked us #12 in Geriatrics.

In addition to our clinical volume, which is large for an academic geriatric division, our effort comprises several special features:

• Physician Excellence: 15 of our faculty are now in America’s Top Docs and/or Best Doctors in America. And, of the 73 physicians (of >3000) to receive UPMC’s Award of Excellence in 2019, 4

T h e D i v i s i o n d e v e l o p e d t h e

Pat ient -Centered Medica l Homespec ifica l ly for

ger iatr ic pat ients

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

were from our faculty.• Vertically-Integrated Care Across the Entire Health Care Spectrum• Chronic Care Management (CCM): We were the first NCQA-certified Patient Centered Medical

Home designed specifically for geriatric patients (Gennari et al., Cleveland Clin J Med,2012;79:359-66). We have now augmented it by creating a program to manage patients withmultiple chronic conditions in compliance with the new CCM billing code. The program is basedon patient goals, involves all members of the care team, and is designed to anticipate and avertproblems in our most complicated patients.

• Group Visits: For >15 years, Dr. Towers has led one of the first such programs in an academiccenter.

• Integrated Geriatric Subspecialty Care: Consultative care is provided by fellowship-trainedgeriatricians, many of whom have additional training in cardiology, chronic pain, gait/mobility,sarcopenia, falls, osteoporosis, pulmonary/critical care, insomnia, incontinence, rheumatology,depression, dementia, audiology, or palliative care. DXA testing is provided by a dually-trainedgeriatric endocrinologist (Dr. Greenspan).

• Geriatric Pharmacists and Social Workers: Our geriatric pharmacists review medications, provideeducation, and counsel patients (cf: Gavini, Gennari, Ruby, Consult Pharm, 2015;30:153). Thisservice is especially important for patients recently discharged from the hospital or SNF and forthose on warfarin. Our social workers serve both inpatients and outpatients. They help with caretransitions, family conferences, and end of life/palliative care discussions. They also provideresources to address care deficits and financial issues, and they educate patients and families on avariety of topics including dementia and insurance coverage.

• Emergency Care: Both UPMC Magee and UPMC Mercy now screen for delirium in every olderpatient in the Emergency Room, and pharmacists review the medications of every patient with apositive screening test.

• Hospitalist and Consult Services: At Shadyside, we staff a geriatrics hospitalist service and aconsult service.

• HELP Program: Based on Dr. Inouye’s program and led by Drs. Rubin and Hassan, this serviceprevents delirium and has saved >$7 million/year since 2008 at UPMC Shadyside (Rubin, JAGS2011 and JAGS 2018)

• UPMC Presbyterian (PUH) Geriatric Trauma Service: Dr. Scandrett initiated this service in 2016 tomeet the needs of >2000 older patients admitted annually to our Level 1 trauma hospital.Readmissions were cut 42%.

• Fracture Liaison Service (UPMC PUH-Shadyside): Dr. Greenspan created this national model toensure that, in addition to surgical repair, those with a fracture are evaluated and treated forosteoporosis (JBMR 2017).

• Telemedicine Service for all of our institutionalized residents, both after hours and on weekends.• Transitional Care Management/Readmission Prevention: Each of our patients is contacted within

48 hours of hospital discharge to review their progress, medications, unanticipated problems, andplans for medical follow-up. Uniquely, we have a similar process for our patients discharged fromSNFs. In addition, for each readmission, the clinicians involved (PCP, hospitalist, NH physician,pharmacist, social worker, and/or home care) strive to identify interventions to prevent futurereadmissions, both at the patient and the system level.

• Advanced Heart Failure: A new unit, created at UPMC’s Canterbury SNF, is led by Drs. Hassan and

NCQA-certified1st

6

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Mathier and designed to reduce readmissions following discharge of patients with TAVR or advanced heart failure.

• Program for All-Inclusive Care of the Elderly (PACE): Directed by one of our adjunct faculty andworking closely with the Division, this multisite program allows frail elderly to continue living athome.

• Nursing Home (NH) and Assisted Living: We provide care for hundreds of these residents, as wellas training and medical leadership to more than a dozen facilities to improve care and reduceunnecessary admissions.

• Provision of Non-Reimbursable Services: our readmission prevention service, an anticoagulationprogram for frail patients, Lifeline® even for those unable to pay, 55 Alive (to assess drivingsafety), and respite care.

CLINICAL QUALITY IMPROVEMENT INITIATIVESOur initiatives focus on each relevant setting. Some highlights include:

Ambulatory CareChronic Care Management (CCM). Focused on frailty and/or multimorbidity, we work with each such patient to develop a care plan in the context of their goals, life expectancy, and current functional status. Because we use this information to develop an action plan and reach out between office visits to assess progress, we qualify for CMS’s chronic care billing code which helps to defray the costs. It also enables us to provide targeted, multidisciplinary care from pharmacists, social workers, and CRNPs to additional patients, and also same day appointments and continuity of care between care settings. These initiatives led to a 97% score on CG CAHPS. Based on our success, other departments have begun to implement the model as well.

Transitional Care Management. In FY19, to determine whether Medicare’s new TCM billing code could enable us to further improve our transitional care, we hired a pharmacy technician to identify, track, and coordinate transitions for all of our patients discharged from a hospital, rehabilitation facility, or SNF. She ensures that each patient is called within two business days of discharge to address questions, unexpected problems, and any anticipated difficulty in being seen for follow-up within two weeks. The program has been well received by patients, staff, and physicians, and won the “2019 People’s Choice” award at the UPMC PUH-SHY Quality Fair. By tracking its efficacy and cost, we hope to be able to systematize the program and disseminate it.

Depression. We continue our CRNP-led depression screening and management program. Based on the PROSPECT study, which was developed by our geropsychiatrists (JAMA, 2004), we screen each of our patients with the PHQ-2, followed as needed by the PHQ-9. A positive score triggers the provider to evaluate and treat the patient according to an algorithm we adapted with input from our geropsychiatrists. Patients are followed for 6-12 months by an interdisciplinary team that monitors response and assists with problem-solving.

Annual Wellness Visits. In FY19, we more than doubled the number of these visits by automatically scheduling patients to see a CRNP before/after their routine PCP visit. During the visit, the focus is on preventive services, immunizations, diet and exercise, and advance directives. We continue to garner top scores for preventive services across UPP.

Emergency CareIn 2015, we and our colleagues in the Magee-Women’s Emergency Department became one of just two US programs selected to work with leaders from the American College of Emergency Physicians and the Society of Academic Emergency Physicians to improve care of older emergency patients. Funded by the Hartford Foundation, our first project began with development of a quality improvement program to enhance detection and management of delirium. Repeated QI cycles have improved nurse-administered screening of older adults from 33% to 90% and the rate of physician confirmatory testing to 85%, with a positive screen triggering a pharmacist review of medications. Reliability was enhanced in FY19 by incorporating the tools and process into the EMR, which has also enabled us to help disseminate the program to UPMC Mercy. The Magee team is now developing a standardized care plan for admitted patients and refining educational tools for patients and family. Follow up of patients with a positive score is underway to determine who can be safely discharged from the ED and the support required. A second project recently began to improve pain management for geriatric patients. The goal is to train ED physicians to provide regional anesthesia with femoral blocks for patients with hip fractures.

Inpatient CareMagee Acute Care and Transitions Program (ACT). Our program was based on two tenets: optimal geriatric care requires anticipating problems and preventing them, and improved systems can help to do so. Led by Dr. Visoiu, over 8 years we identified new problems in medication reconciliation (Marcum et al., J Am Geriatr Soc, 2015 [2 articles]), expanded and enhanced our Geriatric Consult Service, and worked with orthopedics to improve protocols for all fracture patients. We also sustained our previous advances, maintaining low ALOS, complication rates, and readmissions (10%). More gratifying, improvement in these metrics was sustained across the entire medical service for years. Unfortunately, faced with staff turnover, an unforeseen faculty shortage, and increased demand for our help on the PUH Trauma service, we had to suspend the MWH ACT although we continue to provide inpatient Geriatric consults.

Delirium Pathway Project. Led by Dr. Visoiu, we worked with leaders in psychiatry, nursing, ED, and IT to design a Pathway to improve the approach to delirium in older patients. The goal is universal screening, prevention, and enhanced interprofessional management, from the ED to the wards. As described above, we integrated ED screening of all patients >65 years old. Unexpected departures of key faculty and UPMC’s CMIO delayed further intervention, so we switched our focus to reducing nursing documentation, partnering with UPMC’s CNO (Lorenz) and CQO (Minnier). We found that documentation could be substantially streamlined; for instance, we reduced required nurse documentation for a new admission from 36 electronic screens to 8. The hope was to use the freed up time to enable enhanced screening and intervention – not only for delirium, but for other problems as well. Unfortunately, the initiative was suspended owing to UPMC’s new partnership with Microsoft and anticipated changes in the EMR. Fortunately, under Dr. Rubin’sleadership, the successful HELP program continues at Shadyside on 11 wards (JAGS, 2017).Supportive Services Program. Developed in partnership with UPMC’s Health Plan and the Section of Palliative Care, early analyses proved that this program improved care and saved over $500,000/year. Based on its success at UPMC’s PUH, Dr. Tadic launched a new base at UPMC Mercy in FY14 where, over the past 5 years, it has also generated a demand for consults on patients not insured by the Health Plan. Both sites are staffed by a nurse who is backed up by faculty members from geriatrics and palliative care. By identifying and consulting proactively on high risk patients, our goal is to minimize complications, ensure a seamless post-discharge transition, and reduce readmissions.

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Mathier and designed to reduce readmissions following discharge of patients with TAVR or advanced heart failure.

• Program for All-Inclusive Care of the Elderly (PACE): Directed by one of our adjunct faculty and working closely with the Division, this multisite program allows frail elderly to continue living at home.

• Nursing Home (NH) and Assisted Living: We provide care for hundreds of these residents, as well as training and medical leadership to more than a dozen facilities to improve care and reduce unnecessary admissions.

• Provision of Non-Reimbursable Services: our readmission prevention service, an anticoagulation program for frail patients, Lifeline® even for those unable to pay, 55 Alive (to assess driving safety), and respite care.

CLINICAL QUALITY IMPROVEMENT INITIATIVESOur initiatives focus on each relevant setting. Some highlights include:

Ambulatory CareChronic Care Management (CCM). Focused on frailty and/or multimorbidity, we work with each such patient to develop a care plan in the context of their goals, life expectancy, and current functional status. Because we use this information to develop an action plan and reach out between office visits to assess progress, we qualify for CMS’s chronic care billing code which helps to defray the costs. It also enables us to provide targeted, multidisciplinary care from pharmacists, social workers, and CRNPs to additional patients, and also same day appointments and continuity of care between care settings. These initiatives led to a 97% score on CG CAHPS. Based on our success, other departments have begun to implement the model as well.

Transitional Care Management. In FY19, to determine whether Medicare’s new TCM billing code could enable us to further improve our transitional care, we hired a pharmacy technician to identify, track, and coordinate transitions for all of our patients discharged from a hospital, rehabilitation facility, or SNF. She ensures that each patient is called within two business days of discharge to address questions, unexpected problems, and any anticipated difficulty in being seen for follow-up within two weeks. The program has been well received by patients, staff, and physicians, and won the “2019 People’s Choice” award at the UPMC PUH-SHY Quality Fair. By tracking its efficacy and cost, we hope to be able to systematize the program and disseminate it.

Depression. We continue our CRNP-led depression screening and management program. Based on the PROSPECT study, which was developed by our geropsychiatrists (JAMA, 2004), we screen each of our patients with the PHQ-2, followed as needed by the PHQ-9. A positive score triggers the provider to evaluate and treat the patient according to an algorithm we adapted with input from our geropsychiatrists. Patients are followed for 6-12 months by an interdisciplinary team that monitors response and assists with problem-solving.

Annual Wellness Visits. In FY19, we more than doubled the number of these visits by automatically scheduling patients to see a CRNP before/after their routine PCP visit. During the visit, the focus is on preventive services, immunizations, diet and exercise, and advance directives. We continue to garner top scores for preventive services across UPP.

Emergency CareIn 2015, we and our colleagues in the Magee-Women’s Emergency Department became one of just two US programs selected to work with leaders from the American College of Emergency Physicians and the Society of Academic Emergency Physicians to improve care of older emergency patients. Funded by the Hartford Foundation, our first project began with development of a quality improvement program to enhance detection and management of delirium. Repeated QI cycles have improved nurse-administered screening of older adults from 33% to 90% and the rate of physician confirmatory testing to 85%, with a positive screen triggering a pharmacist review of medications. Reliability was enhanced in FY19 by incorporating the tools and process into the EMR, which has also enabled us to help disseminate the program to UPMC Mercy. The Magee team is now developing a standardized care plan for admitted patients and refining educational tools for patients and family. Follow up of patients with a positive score is underway to determine who can be safely discharged from the ED and the support required. A second project recently began to improve pain management for geriatric patients. The goal is to train ED physicians to provide regional anesthesia with femoral blocks for patients with hip fractures.

Inpatient CareMagee Acute Care and Transitions Program (ACT). Our program was based on two tenets: optimal geriatric care requires anticipating problems and preventing them, and improved systems can help to do so. Led by Dr. Visoiu, over 8 years we identified new problems in medication reconciliation (Marcum et al., J Am GeriatrSoc, 2015 [2 articles]), expanded and enhanced our Geriatric Consult Service, and worked with orthopedics to improve protocols for all fracture patients. We also sustained our previous advances, maintaining low ALOS, complication rates, and readmissions (10%). More gratifying, improvement in these metrics was sustained across the entire medical service for years. Unfortunately, faced with staff turnover, an unforeseen faculty shortage, and increased demand for our help on the PUH Trauma service, we had to suspend the MWH ACT although we continue to provide inpatient Geriatric consults.

Delirium Pathway Project. Led by Dr. Visoiu, we worked with leaders in psychiatry, nursing, ED, and IT to design a Pathway to improve the approach to delirium in older patients. The goal is universal screening, prevention, and enhanced interprofessional management, from the ED to the wards. As described above, we integrated ED screening of all patients >65 years old. Unexpected departures of key faculty and UPMC’s CMIO delayed further intervention, so we switched our focus to reducing nursing documentation, partnering with UPMC’s CNO (Lorenz) and CQO (Minnier). We found that documentation could be substantially streamlined; for instance, we reduced required nurse documentation for a new admission from 36 electronic screens to 8. The hope was to use the freed up time to enable enhanced screening and intervention – not only for delirium, but for other problems as well. Unfortunately, the initiative was suspended owing to UPMC’s new partnership with Microsoft and anticipated changes in the EMR. Fortunately, under Dr. Rubin’s leadership, the successful HELP program continues at Shadyside on 11 wards (JAGS, 2017).Supportive Services Program. Developed in partnership with UPMC’s Health Plan and the Section of Palliative Care, early analyses proved that this program improved care and saved over $500,000/year. Based on its success at UPMC’s PUH, Dr. Tadic launched a new base at UPMC Mercy in FY14 where, over the past 5 years, it has also generated a demand for consults on patients not insured by the Health Plan. Both sites are staffed by a nurse who is backed up by faculty members from geriatrics and palliative care. By identifying and consulting proactively on high risk patients, our goal is to minimize complications, ensure a seamless post-discharge transition, and reduce readmissions.

8

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Inpatient Delirium and Dementia. Since 2016, Dr. Tadic has mentored two nurses in their quality improvement initiatives at UPMC Mercy. One employs delirium screening and prevention for inpatients over age 65 on the 12E medical progressive unit. Another uses a designated space (room 10026 on 10E) to help prevent dementia in patients with a history of dementia. Both projects have reduced use of sedative agents as the incidence of delirium declined.

Geriatric Medicine Trauma Consult Service at PUH. We continue providing geriatric consultation for high risk patients at PUH, in partnership with general medicine. Propensity analyses by the Wolff Center in FY18 documented a 42% reduction in readmissions for such patients despite being selected for increased vulnerability.

Fracture Liaison Service (FLS). As national pressure mounts to decrease length of stay, most fracture patients are now discharged without assessment or treatment of the underlying cause. With extramural funding, Dr. Greenspan designed this novel service, which increased bone density screening in such patients from 9% to 57% and appropriate medical treatment from 4% to 45%. This would have translated into an improved rating in the HEDIS measure from 1 star to 4 stars. More importantly, it was accompanied by reduction in the re-fracture rate from 10% to 1.3%. Based on these results, UPMC has supported the program which is now the model advocated by the National Osteoporosis Foundation.

Home CareLiving at Home (Dr. Rodriguez, Medical Director). This team-based preventive program collaborates with PCPs to provide advanced care coordination for roughly 500 high risk, community-dwelling elderly with evidence of inadequate social support and cognitive and functional compromise. Nurses and social workers make home visits to assist with managing medications, keeping medical appointments, arranging in-home and community services, and defining goals of care. Results have been excellent (Castle, Resnick, et al., JApplied Gerontol, 2014), and participation in the program has been consistently associated with lower rates of emergency department visits and hospitalizations.

Long-Term Care (LTC)Reducing Unplanned Admissions. Led by Drs. Nace and Handler, in collaboration with the Aging Institute and Senior Communities, we established a comprehensive program to reduce unplanned admissions from nursing homes (NHs) to the hospital. It focuses on four key phases: a) improved understanding of patients’ care goals, b) earlier detection of deterioration, c) improved communication among team members, and d) use of clinical care pathways. The program reduced unplanned admissions across UPMC-owned NHs by 45% (from 4.9/1000 patient days in Jan 2010 to 2.7 in June 2013, with subsequent plateau). Outcomes of this program were responsible for UPMC Community Provider Services receiving a $19 million CMS Innovation Award (“RAVEN”) to implement and evaluate the program in 20 non-UPMC facilities. Based on the success of the new program, which netted savings of $5 million (Health Affairs 2017), CMS awarded us another $20 million to sustain the intervention in the 20 NHs, replicate it in another 20 NHs, and test a new payment model for all 40 NHs that pays both them and their practitioners to provide higher-level care on site.

Telemedicine. Led by Dr. Handler, and in coordination with Curavi, in FY19 we

expanded our telemedicine service still further. Acquisition of New York’s TripleCare has enabled us to now cover >100 NHs across 14 states. In addition, we expanded our hours of coverage, from 84 to 108 hours of night and weekend coverage per week. Our combined entity has now conducted more than 25,000 consults resulting in >7,800 avoided hospitalizations.

Teledementia. Led by Dr. Rossi, we continued our innovative VA teledementia program (JAGS 2017) and added more VA partners from across the country. Together, they are utilizing national VA and CMS databases to evaluate the novel program’s health impact, as well as its effect on polypharmacy and under-prescribing. In 2017, Dr. Rossi added a new component: telesupport for those who care for these challenging patients. The program has decreased caregiver burden, and she next plans to expand the intervention into patient’s homes.

Dementia Care Management Initiative. The Division has led local and state initiatives to reduce unnecessary antipsychotic usage among nursing home residents. During our leadership of the Pennsylvania Dementia Care Partnership, usage declined 30% statewide in the past 7 years. In addition, by emphasizing an interprofessional team approach, usage at Division-affiliated SNFs has declined as well and is now 15.0%—a level below state and national averages.

Antimicrobial Stewardship. Under Dr. Nace’s leadership, and funded by AHRQ, the Division is spearheading new approaches to antimicrobial stewardship in long-term care. First, he helped to develop a national antimicrobial toolkit (https://www.ahrq.gov/nhguide/index.html). Second, he and his colleagues completed the Optimizing Antibiotic Stewardship in LTC Settings (OASIS) project, which involved 12 sites in Wisconsin and PA. Employing a systems approach, they compared antibiotic prescribing workflows at each site. Communication and collaboration between nursing staff and prescribers were identified as the highest priority targets. Based on the results, a post-prescribing review (“antibiotic timeout”) was tested and analysis of the results is underway. Third, since suspected UTI is the leading cause of inappropriate antibiotic use in the LTC setting, Dr. Nace launched the “Improving Outcomes of UTI Management (IOU)” project. As part of this study, the first evidence-based guidelines for diagnosis and treatment of uncomplicated cystitis were developed and pilot tested in 25 facilities (12 intervention and 13 control sites). The intervention led to a 27% reduction in inappropriate treatment of asymptomatic bacteriuria, a 17% reduction in overall antibiotic use for UTI, and a 67% reduction in C. difficile infections, all without a change in mortality or hospitalizations. The guidelines and tools have been disseminated to all of the original control sites and to two more dissemination cohorts, thereby reaching >50 homes across the country. Based on this work, Dr. Nace received a 2019 grant from the PA Department of Health to train nurses, prescribers, and pharmacists to use the Modified Medication Appropriateness Index for Uncomplicated Cystitis (MMAI-UC), a modified version of a tool used in the IOU study. In addition to training, the project will determine the reliability of applying the tool across disciplines to test whether the MMAI-UC can be used as an antibiotic quality measure. This work is important because all current antibiotic stewardship measures report utilization, but none report on the more important aspect – appropriateness of antibiotic use. Dr. Nace hopes to develop an automated scoring version of this tool which can be incorporated into the National Healthcare Safety Networks (NHSN) reporting system. Dr. Nace and his team received the 2019 ABIM/AMDA Choosing Wisely Champion award for their work on improving antibiotic stewardship for UTI.

Optimal Influenza Vaccines for Older Adults. The Division is collaborating with the Pittsburgh Vaccination Research Group to evaluate the effectiveness of different influenza vaccines in non-frail, pre-frail, and frail older adults. Led by Dr. Nace, this research is also investigating the impact of sarcopenia in vaccine

Drs. Keisha Ward and Rollin Wright were among the many divisional faculty recognized for long term care this year.

9

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Inpatient Delirium and Dementia. Since 2016, Dr. Tadic has mentored two nurses in their quality improvement initiatives at UPMC Mercy. One employs delirium screening and prevention for inpatients over age 65 on the 12E medical progressive unit. Another uses a designated space (room 10026 on 10E) to help prevent dementia in patients with a history of dementia. Both projects have reduced use of sedative agents as the incidence of delirium declined.

Geriatric Medicine Trauma Consult Service at PUH. We continue providing geriatric consultation for high risk patients at PUH, in partnership with general medicine. Propensity analyses by the Wolff Center in FY18 documented a 42% reduction in readmissions for such patients despite being selected for increased vulnerability.

Fracture Liaison Service (FLS). As national pressure mounts to decrease length of stay, most fracture patients are now discharged without assessment or treatment of the underlying cause. With extramural funding, Dr. Greenspan designed this novel service, which increased bone density screening in such patients from 9% to 57% and appropriate medical treatment from 4% to 45%. This would have translated into an improved rating in the HEDIS measure from 1 star to 4 stars. More importantly, it was accompanied by reduction in the re-fracture rate from 10% to 1.3%. Based on these results, UPMC has supported the program which is now the model advocated by the National Osteoporosis Foundation.

Home CareLiving at Home (Dr. Rodriguez, Medical Director). This team-based preventive program collaborates with PCPs to provide advanced care coordination for roughly 500 high risk, community-dwelling elderly with evidence of inadequate social support and cognitive and functional compromise. Nurses and social workers make home visits to assist with managing medications, keeping medical appointments, arranging in-home and community services, and defining goals of care. Results have been excellent (Castle, Resnick, et al., J Applied Gerontol, 2014), and participation in the program has been consistently associated with lower rates of emergency department visits and hospitalizations.

Long-Term Care (LTC)Reducing Unplanned Admissions. Led by Drs. Nace and Handler, in collaboration with the Aging Institute and Senior Communities, we established a comprehensive program to reduce unplanned admissions from nursing homes (NHs) to the hospital. It focuses on four key phases: a) improved understanding of patients’ care goals, b) earlier detection of deterioration, c) improved communication among team members, and d) use of clinical care pathways. The program reduced unplanned admissions across UPMC-owned NHs by 45% (from 4.9/1000 patient days in Jan 2010 to 2.7 in June 2013, with subsequent plateau). Outcomes of this program were responsible for UPMC Community Provider Services receiving a $19 million CMS Innovation Award (“RAVEN”) to implement and evaluate the program in 20 non-UPMC facilities. Based on the success of the new program, which netted savings of $5 million (Health Affairs2017), CMS awarded us another $20 million to sustain the intervention in the 20 NHs, replicate it in another 20 NHs, and test a new payment model for all 40 NHs that pays both them and their practitioners to provide higher-level care on site.

Telemedicine. Led by Dr. Handler, and in coordination with Curavi, in FY19 we

expanded our telemedicine service still further. Acquisition of New York’s TripleCare has enabled us to now cover >100 NHs across 14 states. In addition, we expanded our hours of coverage, from 84 to 108 hours of night and weekend coverage per week. Our combined entity has now conducted more than 25,000 consults resulting in >7,800 avoided hospitalizations.

Teledementia. Led by Dr. Rossi, we continued our innovative VA teledementia program (JAGS 2017) and added more VA partners from across the country. Together, they are utilizing national VA and CMS databases to evaluate the novel program’s health impact, as well as its effect on polypharmacy and under-prescribing. In 2017, Dr. Rossi added a new component: telesupport for those who care for these challenging patients. The program has decreased caregiver burden, and she next plans to expand the intervention into patient’s homes.

Dementia Care Management Initiative. The Division has led local and state initiatives to reduce unnecessary antipsychotic usage among nursing home residents. During our leadership of the Pennsylvania Dementia Care Partnership, usage declined 30% statewide in the past 7 years. In addition, by emphasizing an interprofessional team approach, usage at Division-affiliated SNFs has declined as well and is now 15.0%—a level below state and national averages.

Antimicrobial Stewardship. Under Dr. Nace’s leadership, and funded by AHRQ, the Division is spearheading new approaches to antimicrobial stewardship in long-term care. First, he helped to develop a national antimicrobial toolkit (https://www.ahrq.gov/nhguide/index.html). Second, he and his colleagues completed the Optimizing Antibiotic Stewardship in LTC Settings (OASIS) project, which involved 12 sites in Wisconsin and PA. Employing a systems approach, they compared antibiotic prescribing workflows at each site. Communication and collaboration between nursing staff and prescribers were identified as the highest priority targets. Based on the results, a post-prescribing review (“antibiotic timeout”) was tested and analysis of the results is underway. Third, since suspected UTI is the leading cause of inappropriate antibiotic use in the LTC setting, Dr. Nace launched the “Improving Outcomes of UTI Management (IOU)” project. As part of this study, the first evidence-based guidelines for diagnosis and treatment of uncomplicated cystitis were developed and pilot tested in 25 facilities (12 intervention and 13 control sites). The intervention led to a 27% reduction in inappropriate treatment of asymptomatic bacteriuria, a 17% reduction in overall antibiotic use for UTI, and a 67% reduction in C. difficile infections, all without a change in mortality or hospitalizations. The guidelines and tools have been disseminated to all of the original control sites and to two more dissemination cohorts, thereby reaching >50 homes across the country. Based on this work, Dr. Nace received a 2019 grant from the PA Department of Health to train nurses, prescribers, and pharmacists to use the Modified Medication Appropriateness Index for Uncomplicated Cystitis (MMAI-UC), a modified version of a tool used in the IOU study. In addition to training, the project will determine the reliability of applying the tool across disciplines to test whether the MMAI-UC can be used as an antibiotic quality measure. This work is important because all current antibiotic stewardship measures report utilization, but none report on the more important aspect – appropriateness of antibiotic use. Dr. Nace hopes to develop an automated scoring version of this tool which can be incorporated into the National Healthcare Safety Networks (NHSN) reporting system. Dr. Nace and his team received the 2019 ABIM/AMDA Choosing Wisely Champion award for their work on improving antibiotic stewardship for UTI.

Optimal Influenza Vaccines for Older Adults. The Division is collaborating with the Pittsburgh Vaccination Research Group to evaluate the effectiveness of different influenza vaccines in non-frail, pre-frail, and frail older adults. Led by Dr. Nace, this research is also investigating the impact of sarcopenia in vaccine

Drs. Keisha Ward and Rollin Wright were among the many divisional faculty recognized for long term care this year.

10

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

CLINICAL LOCATIONS

UPMC Benedum Geriatric Center—UPMC Montefiore3459 Fifth Avenue, 4 EastPittsburgh (Oakland), PA 15213

UPMC Senior Care—UPMC ShadysideShadyside Medical Building5200 Centre Avenue, Suite 405Pittsburgh (Shadyside), PA 15232

University of Pittsburgh Osteoporosis Prevention and Treatment CenterKaufmann Medical Building3471 Fifth Avenue, Suite 1110Pittsburgh (Oakland), PA 15213

11

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

CLINICAL LOCATIONS

UPMC Benedum Geriatric Center—UPMC Montefiore3459 Fifth Avenue, 4 EastPittsburgh (Oakland), PA 15213

UPMC Senior Care—UPMC ShadysideShadyside Medical Building5200 Centre Avenue, Suite 405Pittsburgh (Shadyside), PA 15232

University of Pittsburgh Osteoporosis Prevention and Treatment CenterKaufmann Medical Building3471 Fifth Avenue, Suite 1110Pittsburgh (Oakland), PA 15213

12

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

RESEARCH AND OTHER SCHOLARLY ACTIVITIES

The Division of Geriatric Medicine seeks to: (1) conduct cutting-edge research to improve the health of older adults and (2) train the next generation of investigators to do the same. Areas of inquiry includebiology of aging, mobility/falls, frailty/sarcopenia, cardiology, chronic pain, osteoporosis, polypharmacy, incontinence, insomnia, rehabilitation, elder abuse, telemedicine, and long term care. Our funding contributed to Pitt’s being among the nation’s top recipients of NIH funding in aging.

Divisional faculty have found that: (1) healthspan can be reliably assessed in mice, which will enable investigators to better focus on interventions most relevant and promising for human testing (Rizzo); (2) response to physiologic DNA damage drives aging rather than the damage itself (Gurkar); (3) a new biomarker index predicts mortality independent of organ-based comorbidity (Newman); (4) in cognitively normal seniors, there appear to be 2 phenotypes of geriatric urge incontinence, one in which the brain plays the dominant role and a behavioral approach is optimal, and another in which the brain’s role is not key and for which medication may be more effective (Clarkson, Resnick); (5) the HELP program reduces not only delirium and falls but also readmissions (Rubin); (6) among incapacitated ICU patients, discussions often fail to include the patient’s own values and preferences (Scheunemann); and (7) nearly 40% of patients discharged from hospital to a nursing home suffer an adverse event, the majority of which could be prevented (Handler).

This past year, our faculty members were once again recognized for their research. They gave more than 50 presentations at annual meetings of the American Geriatrics Society, Gerontological Society of America, and AMDA. Additionally, both Drs. Scheunemann and Makaroun won AGS Presidential Poster Awards, and Dr. Nace won the ABIM/AMDA Choosing Wisely Award.

Division faculty also served on editorial boards and as visiting professors, committee chairs, and keynote speakers at national and international meetings. For example, Dr. Newman is Editor of the Journal of

Gerontology: Medical Sciences, and Dr. Nace is Associate Editor of JAMDA. Dr. Greenspan serves as President of the National Osteoporosis Foundation. Dr. Forman acted as protagonist in the AGS Plenary Debate Session on statin use while Dr. Hanlon gave the prestigious Peter Lamy Lecture at the ASCP Annual Meeting and served on the AGS’ “Beers Drugs” Update Panel. In addition, Drs. Greenspan and Newman served on NIA’s Board of Scientific Counselors and External Advisory Council, respectively, while Dr. Greenspan also served on NIA’s Clinical Trials Advisory Panel. And, Dr. Forman served as Chairman of the American Heart Association’s Committee on Older Populations.

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

With the departure of 5 investigators to prestigious positions elsewhere, we have spent the past 5 years recruiting and rebuilding. The Research Expenditures graph below reflects funding for which we serve as PI at Pitt, but omits >$2 million of our VA research funding, as well as Dr. Newman’s funding.

Current Division-led ResearchNIH Centers/Program Projects:

• P30 Pepper Older American’s Independence Center (Greenspan)

• T32 to promote training in geriatrics/gerontology (Greenspan)• Center of Excellence in Chronic Pain (Weiner)• Leadership K07 to create a Long-term Care Research Network (Greenspan)

NIH R01/R56/R21s: • Nitrite for HFpEF, and a modified approach to geriatric rehab (MACRO; both R01s [Forman])• CNS mechanisms mediating therapeutic response in overactive bladder (R01 and R56, Resnick)• Pathophysiology of nocturia and behavioral treatment for nocturia (two R21s, Tyagi)• CNS mechanisms involved in situational urgency (R21, Clarkson)• Neural resilience in mobility impairment (Rosano/Hanlon)• Efficacy of zoledronic acid for osteoporosis in institutionalized elderly (R01, Greenspan, Nace,

Resnick)• Efficacy of denosumab for osteoporosis in long-term care (R01, Greenspan, Nace, Resnick)• PCORI trial of home vs. center based cardiac rehabilitation (Forman)• A pragmatic multisite NIH/PCORI-funded trial to prevent injurious falls among high risk elderly

(Greenspan/Resnick)• R00 supplement (Gurkar)

CMS/CMMI-funded:• RAVEN to reduce SNF transfers (Handler, Nace)

VA funding:• Role of hip arthritis in chronic low back pain (Weiner)• Development and validation of clinical prediction rules in seniors with lumbar spinal stenosis

(Weiner)• Patient-centered vs. image-directed treatment of chronic low back pain (Weiner)• Telemedicine approach to improve care of community-based dementia patients (Rossi)

Career Development:• K23 on Alzheimers (Nadkarni)

AHRQ grants: • Reducing adverse drug events in nursing homes (Handler, Hanlon)

I n t h e l a s t f o u r y e a r s ,t h e D i v i s i o n ’s r e s e a r c h

e x p e n d i t u r e s h a v e i n c r e a s e d s t e a d i l y,

w i t h F Y 1 9 t o t a l s b e i n g n e a r l y

than FY15

3x more

13

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

RESEARCH AND OTHER SCHOLARLY ACTIVITIES

The Division of Geriatric Medicine seeks to: (1) conduct cutting-edge research to improve the health of older adults and (2) train the next generation of investigators to do the same. Areas of inquiry include biology of aging, mobility/falls, frailty/sarcopenia, cardiology, chronic pain, osteoporosis, polypharmacy, incontinence, insomnia, rehabilitation, elder abuse, telemedicine, and long term care. Our funding contributed to Pitt’s being among the nation’s top recipients of NIH funding in aging.

Divisional faculty have found that: (1) healthspan can be reliably assessed in mice, which will enable investigators to better focus on interventions most relevant and promising for human testing (Rizzo); (2) response to physiologic DNA damage drives aging rather than the damage itself (Gurkar); (3) a new biomarker index predicts mortality independent of organ-based comorbidity (Newman); (4) in cognitively normal seniors, there appear to be 2 phenotypes of geriatric urge incontinence, one in which the brain plays the dominant role and a behavioral approach is optimal, and another in which the brain’s role is not key and for which medication may be more effective (Clarkson, Resnick); (5) the HELP program reduces not only delirium and falls but also readmissions (Rubin); (6) among incapacitated ICU patients, discussions often fail to include the patient’s own values and preferences (Scheunemann); and (7) nearly 40% of patients discharged from hospital to a nursing home suffer an adverse event, the majority of which could be prevented (Handler).

This past year, our faculty members were once again recognized for their research. They gave more than 50 presentations at annual meetings of the American Geriatrics Society, Gerontological Society of America, and AMDA. Additionally, both Drs. Scheunemann and Makaroun won AGS Presidential Poster Awards, and Dr. Nace won the ABIM/AMDA Choosing Wisely Award.

Division faculty also served on editorial boards and as visiting professors, committee chairs, and keynote speakers at national and international meetings. For example, Dr. Newman is Editor of the Journal of

Gerontology: Medical Sciences, and Dr. Nace is Associate Editor of JAMDA. Dr. Greenspan serves as President of the National Osteoporosis Foundation. Dr. Forman acted as protagonist in the AGS Plenary Debate Session on statin use while Dr. Hanlon gave the prestigious Peter Lamy Lecture at the ASCP Annual Meeting and served on the AGS’ “Beers Drugs” Update Panel. In addition, Drs. Greenspan and Newmanserved on NIA’s Board of Scientific Counselors and External Advisory Council, respectively, while Dr. Greenspan also served on NIA’s Clinical Trials Advisory Panel. And, Dr. Forman served as Chairman of the American Heart Association’s Committee on Older Populations.

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

With the departure of 5 investigators to prestigious positions elsewhere, we have spent the past 5 years recruiting and rebuilding. The Research Expenditures graph below reflects funding for which we serve as PI at Pitt, but omits >$2 million ofour VA research funding, as well as Dr. Newman’s funding.

Current Division-led ResearchNIH Centers/Program Projects:

• P30 Pepper Older American’sIndependence Center(Greenspan)

• T32 to promote training in geriatrics/gerontology (Greenspan)• Center of Excellence in Chronic Pain (Weiner)• Leadership K07 to create a Long-term Care Research Network (Greenspan)

NIH R01/R56/R21s: • Nitrite for HFpEF, and a modified approach to geriatric rehab (MACRO; both R01s [Forman])• CNS mechanisms mediating therapeutic response in overactive bladder (R01 and R56, Resnick)• Pathophysiology of nocturia and behavioral treatment for nocturia (two R21s, Tyagi)• CNS mechanisms involved in situational urgency (R21, Clarkson)• Neural resilience in mobility impairment (Rosano/Hanlon)• Efficacy of zoledronic acid for osteoporosis in institutionalized elderly (R01, Greenspan, Nace,

Resnick)• Efficacy of denosumab for osteoporosis in long-term care (R01, Greenspan, Nace, Resnick)• PCORI trial of home vs. center based cardiac rehabilitation (Forman)• A pragmatic multisite NIH/PCORI-funded trial to prevent injurious falls among high risk elderly

(Greenspan/Resnick)• R00 supplement (Gurkar)

CMS/CMMI-funded:• RAVEN to reduce SNF transfers (Handler, Nace)

VA funding:• Role of hip arthritis in chronic low back pain (Weiner)• Development and validation of clinical prediction rules in seniors with lumbar spinal stenosis

(Weiner)• Patient-centered vs. image-directed treatment of chronic low back pain (Weiner)• Telemedicine approach to improve care of community-based dementia patients (Rossi)

Career Development:• K23 on Alzheimers (Nadkarni)

AHRQ grants: • Reducing adverse drug events in nursing homes (Handler, Hanlon)

I n t h e l a s t f o u r y e a r s ,t h e D i v i s i o n ’s r e s e a r c h

e x p e n d i t u r e s h a v e i n c r e a s e d s t e a d i l y,

w i t h F Y 1 9 t o t a l s b e i n g n e a r l y

than FY153x more

14

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Improving outcomes of UTI in long-term care facilities (Nace)• Telemedicine to transform medication review for high- risk drugs in the nursing home (Handler)• Two complementary grants to devise and implement a novel antibiotic stewardship intervention

for nursing homes (Nace)

Pitt/UPMC funding: • Factors involved in premature and delayed aging using next generation DNA sequencing

(Greenspan/Resnick)• Transcranial stimulation to treat urge incontinence (Clarkson)• Oral nitrite therapy to improve skeletal muscle bioenergetics in older patients (Forman)

Funded Collaborations Divisional faculty also frequently collaborate with researchers outside of the division including

P01/P50s:• Care of Alzheimer’s patients (ADRC, Lopez/Rodriguez and Nadkarni)• Molecular Transducers of Physical Activity Clinical Centers [MotrPAC, Forman/Jakicik])• Sarcopenia mechanisms (SOMMA, Forman/Newman)• Mechanisms of stochastic damage of aging (Robbins, Perera)• Evaluation of new approaches to lower urinary tract dysfunction due to spinal cord injury (Kanai,

Perera)

R01s:• Reduce adverse drug events after discharge to nursing homes (Handler/Kane-Gill)• Task-specific approach to improving gait and mobility (Brach, Perera)• Osteoporosis risk in smokers (Greenspan, Bon)• Activating patients with osteoporosis (Saag, Greenspan)• Aging’s impact on urothelial function (Resnick, Birder)• Impact of obesity on body composition, gait, and function in older adults (Cham, Perera)• Assessing the impact of improved vitamin D status on vascular health and metabolic syndrome risk

(Rajakumar, Greenspan)• Reducing Sedentary Behavior RESET BP (Kline, Perera)

R56/R21/R24/R18s:• Biomarkers to predict lung function decline in physiologically normal smokers (Perera, Sciurba)• Establishment of the research infrastructure to facilitate analyses of Medicare Advantage plans

(Gurwitz, Greenspan)• Dissemination of a diabetes prevention program in seniors (Venditti, Greenspan)• A PCORI-funded trial to examine exercise for fracture prevention in community elderly

(Greenspan/McTigue) A PCORI-funded trial to devise and evaluate a novel group exerciseprogram to reduce falls in assisted living facilities (Brach, Perera)

K01:• To devise a falls risk monitoring algorithm using a data mining technique (Boyce, Perera)• 3 VA Merit Reviews: patterns, determinants, and consequences among veterans receiving opiates

from VA and non-VA sources (Gellad/Hanlon)• Improving safety and appropriateness of prescribing for demented veterans who receive drugs

within and outside of the VA (Hanlon/Gellad)

• Cumulative CNS drug dosage and serious fall injuries (Hanlon, Thorpe)

Additionally, our research training grants support junior faculty, fellows, and medical students. Our T32, which was recently renewed, now includes collaboration with the Aging Institute. Dr. Studenski’s former NIH K07 Leadership Award created a Concentration in Aging Research for Pitt’s Clinical Research Training Program. Until 2017, our Pepper Center funded an embedded K award through the Research Education Core led by Dr. Greenspan. And, Drs. Nace and Wright collaborate on the university’s HRSA-funded Geriatric Education Center (GWEP).

Faculty Research Interests and ActivitiesNeil M. Resnick, MD Division ChiefA Professor of Medicine and Division Chief, Dr. Resnick focuses his research on the pathophysiology and therapy of geriatric syndromes. He serves as PI and Co-I for NIH-funded multidisciplinary studies of urinary incontinence that incorporate physiologic, neuroimaging, clinical, pharmacological and behavioral research aims. In addition, he serves as PI for two foundation-funded initiatives to develop system-based approaches to prevent, detect, and treat delirium in hospitalized patients. He is also a Co-Investigator on Dr. Greenspan’s research in geriatric osteoporosis, including her R01-funded studies in the nursing home and a PCORI-funded study of falls. Finally, he co-directs the Research and Career Development Core of the NIH-funded Pittsburgh Older Americans Independence Center, and he leads the Older Adult Research Network for the Pittsburgh Clinical and Translational Science Institute (CTSI).

Study Sections• Reviewer, Study Section (Ad Hoc), Division of Research Grants, NIH, 1983-present• Member, Abstract Review Committee, American Geriatrics Society, 1985-present• Member, Governing Board, Simon Foundation, 1986-present• Reviewer, Study Section, Gerontology and Geriatrics (Ad Hoc), NIA/NIH, 1988-present• Reviewer, Gerontological Society of America, 1989-present

Advisory Committee Memberships and Leadership Positions• Member, Scientific Advisory Board, Simon Foundation, 1984-present• Member, Scientific Advisory Board, American Federation of Aging Research, 1989-present• Member, Invited Panel, American College of Physician, “Meet the Professor”, 1990-present• Member, Advisory Committee, Alliance for Aging Research, 1991-present• Member, Advisory Committee, Geriatric Research Education and Clinical Center (GRECC),

Pittsburgh VA Health System, 1999-present• Member, Long Term Care Committee, University of Pittsburgh, 1999-present• Member, Board of Directors, Pennsylvania American Geriatrics Society, 2000-present• Co-Director, Pennsylvania American Geriatrics Society CME course: Clinical Update in Geriatric

Medicine, 2000-present• Co-Chair, Council of State Affiliates, American Geriatrics Society, 2003-present• Member, National Mentoring Program, American Geriatrics Society, 2005-present• Member, Board of Directors, Pittsburgh Regional Health Initiative (PRHI), 2012-present• Member, Board of Directors, Jewish Healthcare Foundation, 2012-present• Advisor, CMS/Medicare Innovation Advisors Program, 2014-present• Member, Board of Directors, American Geriatrics Society, 2018-present

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Improving outcomes of UTI in long-term care facilities (Nace)• Telemedicine to transform medication review for high- risk drugs in the nursing home (Handler)• Two complementary grants to devise and implement a novel antibiotic stewardship intervention

for nursing homes (Nace)

Pitt/UPMC funding: • Factors involved in premature and delayed aging using next generation DNA sequencing

(Greenspan/Resnick)• Transcranial stimulation to treat urge incontinence (Clarkson)• Oral nitrite therapy to improve skeletal muscle bioenergetics in older patients (Forman)

Funded CollaborationsDivisional faculty also frequently collaborate with researchers outside of the division including

P01/P50s:• Care of Alzheimer’s patients (ADRC, Lopez/Rodriguez and Nadkarni)• Molecular Transducers of Physical Activity Clinical Centers [MotrPAC, Forman/Jakicik])• Sarcopenia mechanisms (SOMMA, Forman/Newman)• Mechanisms of stochastic damage of aging (Robbins, Perera)• Evaluation of new approaches to lower urinary tract dysfunction due to spinal cord injury (Kanai,

Perera)

R01s:• Reduce adverse drug events after discharge to nursing homes (Handler/Kane-Gill)• Task-specific approach to improving gait and mobility (Brach, Perera)• Osteoporosis risk in smokers (Greenspan, Bon)• Activating patients with osteoporosis (Saag, Greenspan)• Aging’s impact on urothelial function (Resnick, Birder)• Impact of obesity on body composition, gait, and function in older adults (Cham, Perera)• Assessing the impact of improved vitamin D status on vascular health and metabolic syndrome risk

(Rajakumar, Greenspan)• Reducing Sedentary Behavior RESET BP (Kline, Perera)

R56/R21/R24/R18s:• Biomarkers to predict lung function decline in physiologically normal smokers (Perera, Sciurba)• Establishment of the research infrastructure to facilitate analyses of Medicare Advantage plans

(Gurwitz, Greenspan)• Dissemination of a diabetes prevention program in seniors (Venditti, Greenspan)• A PCORI-funded trial to examine exercise for fracture prevention in community elderly

(Greenspan/McTigue) A PCORI-funded trial to devise and evaluate a novel group exercise program to reduce falls in assisted living facilities (Brach, Perera)

K01:• To devise a falls risk monitoring algorithm using a data mining technique (Boyce, Perera)• 3 VA Merit Reviews: patterns, determinants, and consequences among veterans receiving opiates

from VA and non-VA sources (Gellad/Hanlon)• Improving safety and appropriateness of prescribing for demented veterans who receive drugs

within and outside of the VA (Hanlon/Gellad)

• Cumulative CNS drug dosage and serious fall injuries (Hanlon, Thorpe)

Additionally, our research training grants support junior faculty, fellows, and medical students. Our T32, which was recently renewed, now includes collaboration with the Aging Institute. Dr. Studenski’s former NIH K07 Leadership Award created a Concentration in Aging Research for Pitt’s Clinical Research Training Program. Until 2017, our Pepper Center funded an embedded K award through the Research Education Core led by Dr. Greenspan. And, Drs. Nace and Wright collaborate on the university’s HRSA-funded Geriatric Education Center (GWEP).

Faculty Research Interests and ActivitiesNeil M. Resnick, MD Division ChiefA Professor of Medicine and Division Chief, Dr. Resnick focuses his research on the pathophysiology and therapy of geriatric syndromes. He serves as PI and Co-I for NIH-funded multidisciplinary studies of urinary incontinence that incorporate physiologic, neuroimaging, clinical, pharmacological and behavioral research aims. In addition, he serves as PI for two foundation-funded initiatives to develop system-based approaches to prevent, detect, and treat delirium in hospitalized patients. He is also a Co-Investigator on Dr. Greenspan’s research in geriatric osteoporosis, including her R01-funded studies in the nursing home and a PCORI-funded study of falls. Finally, he co-directs the Research and Career Development Core of the NIH-funded Pittsburgh Older Americans Independence Center, and he leads the Older Adult Research Network for the Pittsburgh Clinical and Translational Science Institute (CTSI).

Study Sections• Reviewer, Study Section (Ad Hoc), Division of Research Grants, NIH, 1983-present• Member, Abstract Review Committee, American Geriatrics Society, 1985-present• Member, Governing Board, Simon Foundation, 1986-present• Reviewer, Study Section, Gerontology and Geriatrics (Ad Hoc), NIA/NIH, 1988-present• Reviewer, Gerontological Society of America, 1989-present

Advisory Committee Memberships and Leadership Positions• Member, Scientific Advisory Board, Simon Foundation, 1984-present• Member, Scientific Advisory Board, American Federation of Aging Research, 1989-present• Member, Invited Panel, American College of Physician, “Meet the Professor”, 1990-present• Member, Advisory Committee, Alliance for Aging Research, 1991-present• Member, Advisory Committee, Geriatric Research Education and Clinical Center (GRECC),

Pittsburgh VA Health System, 1999-present• Member, Long Term Care Committee, University of Pittsburgh, 1999-present• Member, Board of Directors, Pennsylvania American Geriatrics Society, 2000-present• Co-Director, Pennsylvania American Geriatrics Society CME course: Clinical Update in Geriatric

Medicine, 2000-present• Co-Chair, Council of State Affiliates, American Geriatrics Society, 2003-present• Member, National Mentoring Program, American Geriatrics Society, 2005-present• Member, Board of Directors, Pittsburgh Regional Health Initiative (PRHI), 2012-present• Member, Board of Directors, Jewish Healthcare Foundation, 2012-present• Advisor, CMS/Medicare Innovation Advisors Program, 2014-present• Member, Board of Directors, American Geriatrics Society, 2018-present

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Professional Affiliations and Society Memberships• Member, Gerontological Society of America, 1981-present• Member, Urodynamics Society, 1982-present• Member, American Urological Association (Affiliate Member), 1985-present

Editorships• Editorial Board, Current Geriatrics Reports, 2014-present

Major Lectureships and Seminars• Invited Lecturer, Update in Geriatric Medicine, Pennsylvania American Geriatrics Society, 2000-

present• Lecturer, Governor’s School (University of Pittsburgh Health Scholars Academy), 2000-present• Lecturer, Meet the Professor Sessions, American College of Physicians Annual Meeting, 2017-

present• Invited Lecturer, International Continence Society Annual Scientific Meeting, Philadelphia, 2018• Invited Lecturer, Annual Scientific Meeting, Gerontological Society of America (GSA), Boston, MA,

2018Honors and Awards

• Honoree, Best Doctors in America, Best Doctors Inc, 1992-present• Honoree, Top Doctors in America, Castle Connolly’s Guide to America’s Top Physicians, 2000-

present• Honoree, Best Doctors, Pittsburgh Magazine, 2002-present

Becky D. Clarkson, PhDDr. Clarkson is a Research Assistant Professor of Medicine. Originally trained as a medical physicist, she uses her experience of developing clinical tests and diagnostic tools to integrate brain imaging and bladder provocation to understand and treat bladder dysfunction related to higher control mechanisms. Her NIH-funded research focuses on environmental triggers of urinary leakage and using MRI to characterize the central neural control system of the continence mechanism. She is currently using the findings from this research as the basis for developing therapies for urgency incontinence which focus on bladder control, specifically behavioral therapies, and brain stimulation methods.

Advisory Committee Memberships and Leadership Positions• Co-Chair, Brain Bladder Research and Imaging Network, 2016-present• Co-Chair, Biomedical Engineering section, INTEL ISEF, 2018

Professional Affiliations and Society Memberships• Member, Institute for Physics and Engineering in Medicine, 2004-present• Member, International Continence Society, 2007-present• Member, International Consultation on Incontinence Research Society, 2018

Major Lectureships and Seminars• Invited Speaker, Neurogenic Bladder Research Group (NBRG) Meeting, 2019

Daniel E. Forman, MDA Professor of Medicine, Dr. Forman is dually trained in geriatrics and cardiology. He holds appointments in both Divisions at UPMC as well as in both the Geriatrics Research Education and Clinical Center (GRECC) and the Cardiology Division at the Pittsburgh VA. With NIH funding, he is studying the benefit of nitrate capsules

for fatigue and function in older adults with heart failure and preserved ejection fraction. In two other NIH projects, he is studying the impact of exercise on skeletal muscle gene transcription (Molecular Transducers of Physical Activity in Humans [MoTrPAC]) and the impact of exercise training on cognition (Investigating Gains in Neurocognition in an Intervention Trial of Exercise [IGNITE]). At the VA, he is comparing the impact of different training regimens (strength, aerobic, and inspiratory muscle training) on skeletal muscle morphology, gene expression, and functional capacity. He is also researching the utility of prehabilitation in frail elderly prior to abdominal and cardiothoracic surgery. Finally, Dr. Forman is funded by PCORI to devise novel strategies to improve cardiac rehabilitation, especially methods to improve enrollment, adherence, and value for complex, older cardiovascular patients.

Study Sections

• Scientific Reviewer, Increasing Use of Cardiovascular and Pulmonary Rehabilitation in Traditional and Community Settings Study Section (NHLBI RFA-HL-18-019), 2018

• Scientific Reviewer, NHLBI UG3/U24 study section, 2019Advisory Committee Memberships and Leadership Positions

• Chair, Advocacy Workgroup, Geriatric Cardiology Section, American College of Cardiology, 2014-present

• Chair, International Workgroup, Geriatric Cardiology Section, American College of Cardiology, 2014-present

• Member and Representative, Cholesterol Guideline Committee and American Geriatric Society, American College of Cardiology/American Heart Association, 2017-present

• Chair, Geriatric Cardiology Panel, Annual Update in Geriatric Medicine, University of Pittsburgh, 2019

Professional Affiliations and Society Memberships• Member, Geriatric Cardiology Section, American College of Cardiology, 2010-present

Editorships

• Editorial Board, Journal of the American Geriatrics Society, 2014-present• Associate Editor-in-Chief, Journal of Geriatric Cardiology, 2015-present• Editorial Board, Journal of Cardiopulmonary Rehabilitation and Prevention, 2016-present• Editorial Board, Journal of the American Geriatrics Society, Cardiology, 2016-present• Editorial Board, The Journal of Gerontology: Medical Sciences, 2017-present• Guest Editor, Circulation, 2017-present• Guest Editor, Journal of the American College of Cardiology, 2018-present

Major Lectureships and Seminars

• Invited Lecturer, Department of Physical Medicine and Rehabilitation Panther Grand Rounds, University of Pittsburgh, 2018

• Invited Speaker, Plenary Session Debate, American Geriatric Society Annual Meeting, Orlando, FL, 2018

• Invited Speaker, National VA Webinar sponsored by Promising Practices, Office of Rural Health, 2018

• Invited Speaker, American Association of Cardiovascular and Pulmonary Rehabilitation Annual Meeting, Louisville, KY, 2018

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Professional Affiliations and Society Memberships• Member, Gerontological Society of America, 1981-present• Member, Urodynamics Society, 1982-present• Member, American Urological Association (Affiliate Member), 1985-present

Editorships• Editorial Board, Current Geriatrics Reports, 2014-present

Major Lectureships and Seminars• Invited Lecturer, Update in Geriatric Medicine, Pennsylvania American Geriatrics Society, 2000-

present• Lecturer, Governor’s School (University of Pittsburgh Health Scholars Academy), 2000-present• Lecturer, Meet the Professor Sessions, American College of Physicians Annual Meeting, 2017-

present• Invited Lecturer, International Continence Society Annual Scientific Meeting, Philadelphia, 2018• Invited Lecturer, Annual Scientific Meeting, Gerontological Society of America (GSA), Boston, MA,

2018Honors and Awards

• Honoree, Best Doctors in America, Best Doctors Inc, 1992-present• Honoree, Top Doctors in America, Castle Connolly’s Guide to America’s Top Physicians, 2000-

present• Honoree, Best Doctors, Pittsburgh Magazine, 2002-present

Becky D. Clarkson, PhDDr. Clarkson is a Research Assistant Professor of Medicine. Originally trained as a medical physicist, she uses her experience of developing clinical tests and diagnostic tools to integrate brain imaging and bladder provocation to understand and treat bladder dysfunction related to higher control mechanisms. Her NIH-funded research focuses on environmental triggers of urinary leakage and using MRI to characterize the central neural control system of the continence mechanism. She is currently using the findings from this research as the basis for developing therapies for urgency incontinence which focus on bladder control, specifically behavioral therapies, and brain stimulation methods.

Advisory Committee Memberships and Leadership Positions• Co-Chair, Brain Bladder Research and Imaging Network, 2016-present• Co-Chair, Biomedical Engineering section, INTEL ISEF, 2018

Professional Affiliations and Society Memberships• Member, Institute for Physics and Engineering in Medicine, 2004-present• Member, International Continence Society, 2007-present• Member, International Consultation on Incontinence Research Society, 2018

Major Lectureships and Seminars• Invited Speaker, Neurogenic Bladder Research Group (NBRG) Meeting, 2019

Daniel E. Forman, MDA Professor of Medicine, Dr. Forman is dually trained in geriatrics and cardiology. He holds appointments in both Divisions at UPMC as well as in both the Geriatrics Research Education and Clinical Center (GRECC) and the Cardiology Division at the Pittsburgh VA. With NIH funding, he is studying the benefit of nitrate capsules

for fatigue and function in older adults with heart failure and preserved ejection fraction. In two other NIH projects, he is studying the impact of exercise on skeletal muscle gene transcription (Molecular Transducers of Physical Activity in Humans [MoTrPAC]) and the impact of exercise training on cognition (Investigating Gains in Neurocognition in an Intervention Trial of Exercise [IGNITE]). At the VA, he is comparing the impact of different training regimens (strength, aerobic, and inspiratory muscle training) on skeletal muscle morphology, gene expression, and functional capacity. He is also researching the utility of prehabilitation in frail elderly prior to abdominal and cardiothoracic surgery. Finally, Dr. Forman is funded by PCORI to devise novel strategies to improve cardiac rehabilitation, especially methods to improve enrollment, adherence, and value for complex, older cardiovascular patients.

Study Sections

• Scientific Reviewer, Increasing Use of Cardiovascular and Pulmonary Rehabilitation in Traditionaland Community Settings Study Section (NHLBI RFA-HL-18-019), 2018

• Scientific Reviewer, NHLBI UG3/U24 study section, 2019Advisory Committee Memberships and Leadership Positions

• Chair, Advocacy Workgroup, Geriatric Cardiology Section, American College of Cardiology, 2014-present

• Chair, International Workgroup, Geriatric Cardiology Section, American College of Cardiology,2014-present

• Member and Representative, Cholesterol Guideline Committee and American Geriatric Society,American College of Cardiology/American Heart Association, 2017-present

• Chair, Geriatric Cardiology Panel, Annual Update in Geriatric Medicine, University of Pittsburgh,2019

Professional Affiliations and Society Memberships• Member, Geriatric Cardiology Section, American College of Cardiology, 2010-present

Editorships

• Editorial Board, Journal of the American Geriatrics Society, 2014-present• Associate Editor-in-Chief, Journal of Geriatric Cardiology, 2015-present• Editorial Board, Journal of Cardiopulmonary Rehabilitation and Prevention, 2016-present• Editorial Board, Journal of the American Geriatrics Society, Cardiology, 2016-present• Editorial Board, The Journal of Gerontology: Medical Sciences, 2017-present• Guest Editor, Circulation, 2017-present• Guest Editor, Journal of the American College of Cardiology, 2018-present

Major Lectureships and Seminars

• Invited Lecturer, Department of Physical Medicine and Rehabilitation Panther Grand Rounds,University of Pittsburgh, 2018

• Invited Speaker, Plenary Session Debate, American Geriatric Society Annual Meeting, Orlando, FL,2018

• Invited Speaker, National VA Webinar sponsored by Promising Practices, Office of Rural Health,2018

• Invited Speaker, American Association of Cardiovascular and Pulmonary Rehabilitation AnnualMeeting, Louisville, KY, 2018

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Invited Speaker, Cardiology Grand Rounds, Case Western University School of Medicine, 2018• Invited Speaker, Update in Internal Medicine 2018, University of Pittsburgh, 2018• Invited Speaker, American Heart Association Scientific Sessions, Chicago, IL, 2018• Invited Speaker, Aging and Cancer Brainstorming Workshop, University of Pittsburgh, 2019• Invited Speaker, Workshop on Embedding/Sustaining a Focus on Function in Specialty Research

and Care, NIA U13 conference, Washington, DC, 2019• Invited Speaker, Annual Update in Geriatric Medicine, University of Pittsburgh, 2019• Invited Speaker, Delegation from the American Heart Association at the 15th International

Congress of Update in Cardiology and Cardiovascular Surgery (UCCVS), Antalya, Turkey, 2019• Keynote speaker, American Geriatrics Society, Portland, Oregon, 2019• Invited Speaker, Meyers Visiting Professor of Geriatric Medicine, University of Massachusetts

School of Medicine, 2019

Amelia S. Gennari, MDDr. Gennari leads the Division's innovative efforts in developing a Geriatric Patient Centered Medical Home and serves as head of the Division's Clinical Task Force. Additionally, she has a strong commitment to education and plays an active role in teaching medical students, residents and geriatric fellows in the inpatient, outpatient and long term care settings.

Advisory Committee Memberships and Leadership Positions• Member, Education Committee, University of Pittsburgh, 2015-present• Co-Director, New Resident Green Team Configuration, University of Pittsburgh Medical Center,

2018Honors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2017-present

Susan L. Greenspan, MDA Professor of Medicine, Dr. Greenspan is dually-trained in Geriatrics and in Endocrinology, and she serves as UPMC’s Director of the Osteoporosis Prevention and Treatment Center and as Director of Bone Health at Magee Women’s Hospital. Her research focuses on geriatric osteoporosis, including its pathophysiology, evaluation, and treatment. Her current R01s focus on osteoporosis in institutionalized elderly, including new treatment modalities and new assessments of bone strength. In addition, she is PI of our NIH-funded Pepper Center, our NIH T32 Pitt Integrated Clinical and Geroscience Research Training Program, and has a K07 that has developed a research registry and network for research in senior communities. A former member of NIH/NIA’s Board of Scientific Counselors, she now serves on NIA’s Clinical Trial Advisory Panel. She is also President of the National Osteoporosis Foundation and a member of its Board of Trustees.

Advisory Committee Memberships and Leadership Positions• Co-Founder and Core Faculty, International Society of Clinical Densitometry Certification

Program, 1997-present• Core Faculty, National Osteoporosis Foundation (in association with ISO) annual meeting, 2010-

present• Director, T32 training grant, 2014-present• Member, NIH/NIA Clinical Trials Advisory Program (CTAP), 2014-present• Team Member, FNIH Sarcopenia Project, 2017-present

• Co-Chair, National Bone Health Alliance, 2018-present• Member, Steering Committee, American Society of Bone and Mineral Research Secondary

Fracture Prevention, 2018-present• Member, Steering Committee, Fracture Liaison Service Key Outcome Measures, 2018-present

Editorships• Editorial Board, Journal of Gerontology, Medical Sciences, 1999-present• Editorial Board, National Osteoporosis Foundation, 2004-present

Major Lectureships and Seminars• Lecturer, Endocrine Society Fellows Series, 2018-present• Lecturer, ASBMR Society Fellows Forum, 2018-present

Aditi U. Gurkar, PhDDr. Gurkar’s interest is in understanding the biology of aging and age-related diseases. Her NIH-funded research focuses on identifying the signaling mechanisms that drive aging in response to endogenous DNA damage. By defining these molecular mechanism(s), she hopes to identify novel therapeutic targets that can be exploited to extend healthspan.

Advisory Committee Memberships and Leadership Positions• Poster judge, Research Day, Department of Medicine, Pittsburgh, April 2019

Editorships

• Ad hoc reviewer, DNA Repair, 2019Major Lectureships and Seminars

• Invited speaker, The Pittsburgh Institute for Neurodegenerative Diseases, February 2019• Invited speaker, Geriatric Medicine and Psychiatry Fellowship Integrated Lecture Series on

“Biology of Aging,” April 2019• Invited speaker, Veterans Administration Research Day 2019, May 2019• Invited speaker, American Aging Association 48th Annual Meeting, San Francisco CA, May 2019• Invited speaker, 8th Annual University of Pittsburgh and Tsinghua University Joint Symposium,

May 2019 Honors and Awards

• First prize, Bench Junior Faculty, Aging Institute Research Day, University of Pittsburgh, 2018

Steven M. Handler, MD, PhDAn Associate Professor of Geriatrics, Dr. Handler also holds appointments in Biomedical Informatics and in Clinical and Translational Research. In addition to his role as Director of Geriatric Telemedicine Programs, he serves as Medical Director for Telemedicine and Health Information for the RAVEN (Reduce AVoidable hospitalization using Evidence-based interventions for Nursing facilities in Western Pennsylvania) CMS Innovation Award. A practicing geriatrician, Dr. Handler’s primary research focuses on medication and patient safety, telemedicine, and clinical decision support systems for older adults in the post-acute and long-term care setting.

Advisory Committee Memberships and Leadership Positions• Steering Committee Member, Long-Term Care Research Network, American Medical Directors

Association (AMDA), 2006-present

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Invited Speaker, Cardiology Grand Rounds, Case Western University School of Medicine, 2018• Invited Speaker, Update in Internal Medicine 2018, University of Pittsburgh, 2018• Invited Speaker, American Heart Association Scientific Sessions, Chicago, IL, 2018• Invited Speaker, Aging and Cancer Brainstorming Workshop, University of Pittsburgh, 2019• Invited Speaker, Workshop on Embedding/Sustaining a Focus on Function in Specialty Research

and Care, NIA U13 conference, Washington, DC, 2019• Invited Speaker, Annual Update in Geriatric Medicine, University of Pittsburgh, 2019• Invited Speaker, Delegation from the American Heart Association at the 15th International

Congress of Update in Cardiology and Cardiovascular Surgery (UCCVS), Antalya, Turkey, 2019• Keynote speaker, American Geriatrics Society, Portland, Oregon, 2019• Invited Speaker, Meyers Visiting Professor of Geriatric Medicine, University of Massachusetts

School of Medicine, 2019

Amelia S. Gennari, MDDr. Gennari leads the Division's innovative efforts in developing a Geriatric Patient Centered Medical Home and serves as head of the Division's Clinical Task Force. Additionally, she has a strong commitment to education and plays an active role in teaching medical students, residents and geriatric fellows in the inpatient, outpatient and long term care settings.

Advisory Committee Memberships and Leadership Positions• Member, Education Committee, University of Pittsburgh, 2015-present• Co-Director, New Resident Green Team Configuration, University of Pittsburgh Medical Center,

2018Honors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2017-present

Susan L. Greenspan, MDA Professor of Medicine, Dr. Greenspan is dually-trained in Geriatrics and in Endocrinology, and she serves as UPMC’s Director of the Osteoporosis Prevention and Treatment Center and as Director of Bone Health at Magee Women’s Hospital. Her research focuses on geriatric osteoporosis, including its pathophysiology, evaluation, and treatment. Her current R01s focus on osteoporosis in institutionalized elderly, including new treatment modalities and new assessments of bone strength. In addition, she is PI of our NIH-funded Pepper Center, our NIH T32 Pitt Integrated Clinical and Geroscience Research Training Program, and has a K07 that has developed a research registry and network for research in senior communities. A former member of NIH/NIA’s Board of Scientific Counselors, she now serves on NIA’s Clinical Trial Advisory Panel. She is also President of the National Osteoporosis Foundation and a member of its Board of Trustees.

Advisory Committee Memberships and Leadership Positions• Co-Founder and Core Faculty, International Society of Clinical Densitometry Certification

Program, 1997-present• Core Faculty, National Osteoporosis Foundation (in association with ISO) annual meeting, 2010-

present• Director, T32 training grant, 2014-present• Member, NIH/NIA Clinical Trials Advisory Program (CTAP), 2014-present• Team Member, FNIH Sarcopenia Project, 2017-present

• Co-Chair, National Bone Health Alliance, 2018-present• Member, Steering Committee, American Society of Bone and Mineral Research Secondary

Fracture Prevention, 2018-present• Member, Steering Committee, Fracture Liaison Service Key Outcome Measures, 2018-present

Editorships• Editorial Board, Journal of Gerontology, Medical Sciences, 1999-present• Editorial Board, National Osteoporosis Foundation, 2004-present

Major Lectureships and Seminars• Lecturer, Endocrine Society Fellows Series, 2018-present• Lecturer, ASBMR Society Fellows Forum, 2018-present

Aditi U. Gurkar, PhDDr. Gurkar’s interest is in understanding the biology of aging and age-related diseases. Her NIH-funded research focuses on identifying the signaling mechanisms that drive aging in response to endogenous DNA damage. By defining these molecular mechanism(s), she hopes to identify novel therapeutic targets that can be exploited to extend healthspan.

Advisory Committee Memberships and Leadership Positions• Poster judge, Research Day, Department of Medicine, Pittsburgh, April 2019

Editorships

• Ad hoc reviewer, DNA Repair, 2019Major Lectureships and Seminars

• Invited speaker, The Pittsburgh Institute for Neurodegenerative Diseases, February 2019• Invited speaker, Geriatric Medicine and Psychiatry Fellowship Integrated Lecture Series on

“Biology of Aging,” April 2019• Invited speaker, Veterans Administration Research Day 2019, May 2019• Invited speaker, American Aging Association 48th Annual Meeting, San Francisco CA, May 2019• Invited speaker, 8th Annual University of Pittsburgh and Tsinghua University Joint Symposium,

May 2019Honors and Awards

• First prize, Bench Junior Faculty, Aging Institute Research Day, University of Pittsburgh, 2018

Steven M. Handler, MD, PhDAn Associate Professor of Geriatrics, Dr. Handler also holds appointments in Biomedical Informatics and in Clinical and Translational Research. In addition to his role as Director of Geriatric Telemedicine Programs, he serves as Medical Director for Telemedicine and Health Information for the RAVEN (Reduce AVoidable hospitalization using Evidence-based interventions for Nursing facilities in Western Pennsylvania) CMS Innovation Award. A practicing geriatrician, Dr. Handler’s primary research focuses on medication and patient safety, telemedicine, and clinical decision support systems for older adults in the post-acute and long-term care setting.

Advisory Committee Memberships and Leadership Positions• Steering Committee Member, Long-Term Care Research Network, American Medical Directors

Association (AMDA), 2006-present

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Technical Expert, “Developing a Patient Safety Culture Instrument for Nursing Home Use,” WestatResearch Corporation, 2006-present

• Member, Health Information Technology (HIT) Subcommittee, American Medical DirectorsAssociation (AMDA), 2008-present

• Developer, Institute for Healthcare Improvement (IHI), Trigger Tool for Measuring Adverse DrugEvents in the Nursing Home, 2009-present

• Technical Expert and Physician Lead, Physician and Patient Safety, Raising Awareness for ReducingAdverse Events in Nursing Homes Campaign, Centers for Medicare and Medicaid Services (CMS),2014-present

• Safety Expert Panelist, Center for Medicare and Medicaid Services’ (CMS) Innovation Center,F-329 (Unnecessary Drugs) Guidance for State Surveyors Redesign Committee, 2012-present

• Member, Center for Medicare and Medicaid Services’ (CMS) Innovation Center, Enhanced Careand Coordination Provider (ECCP) Medical Director Council, 2013-present

• Member, Executive Committee for Quality Prescribing Campaign, AMDA/Society for Post-Acuteand Long-Term Care, 2015-present

• Member, Taskforce on Quality Improvement in Nursing Home Regulation and Oversight, PA Dept.of Health, 2015-present

• Member, Framework Development to Support Measure Development for Telehealth, NationalQuality Foundation (NQF), 2016-present

• Member, Workgroup, Society for Post-Acute and Long-Term Care (AMDA), Telemedicine 2017-present

• Matter Expert, Subject telemedicine and co-author of Implementing Telehealth in Post-Acute andLong-Term Care Settings (PALTC), West Health Institute, 2019-present

Joseph T. Hanlon, PharmD, MSAn Emeritus Professor of Medicine, Dr. Hanlon is also a geriatric pharmacist and health scientist with both the Center for Health Equity Research and Promotion (CHERP) and the Geriatric Research Education and Clinical Center (GRECC) at the Pittsburgh VA. His research focuses on three themes: 1) drug-related problems, 2) racial disparities in medication use, and 3) drug-induced geriatric syndromes. He serves as a Co-I and Consultant on a number of federally funded grants and on the editorial boards of four journals.

Advisory Committee Memberships and Leadership Positions• Member, Geriatric Advisory Panel, “Modifying the Impact of ICU-Induced Neurological

Dysfunction-USA Study” (MIND-USA), Vanderbilt University, 2009-2018• Member, “Beers List” Updating Panel, American Geriatrics Society, 2011-present• Member, Technical Advisory Committee, PACE Program, Harrisburg, PA, 2012-2018• Consultant, VA funded Patient Safety Center of Inquiry: Safeguarding Ambulatory Care For

Veterans With Chronic Kidney Disease, 2016-2018• Consultant, “Addressing Behavior and Mood in Assisted Living: Organizational Characteristics

Related to the Use of Antipsychotic and Psychotropic Medications and Alternative Practices,”University of North Carolina-Chapel Hill, 2016-present

• Consultant, “Reducing High-Risk Geriatric Polypharmacy via EHR Nudges” (NIA funded R21),RAND Boston, 2017-present

• Consultant, “Pilot Study of Standardized Patient-Centered Medication Review (Spectorx) in HomeHospice” (NIA funded R21), UMASS-Worcester, 2018-present

Editorships• Editorial Board, Dementia Panel, Annals of Pharmacotherapy, 2003-present• Editorial Board, Journal of Gerontology: Medical Sciences, 2014-present• Editorial Board, Drugs and Aging, 2014-present• Editorial Board, Journal of American Medical Directors Association, 2018-present

Shuja Hassan, MDDr. Hassan provides primary care and consultative services to older adults at UPMC Senior Care-Shadyside. He is board certified in Internal Medicine and Geriatrics. Dr Hassan is also the Medical Director at UPMC Canterbury Place, a long-term care facility.

Advisory Committee Memberships and Leadership Positions• Associate Director, Geriatrics Rotation, UPMC Shadyside, 2004-present• Co-Director, Clinical Update in Geriatric Medicine CME Course, American Geriatrics Society

(Pennsylvania Chapter), University of Pittsburgh, 2009-presentMajor Lectureships and Seminars

• Presenter, Annual Clinical Update in Geriatric Medicine Conference, Pittsburgh, PA, May 2019Honors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Mary P. Kotlarczyk, PhDDr. Kotlarczyk is a Research Assistant Professor of Medicine and Associate Director of the Osteoporosis Prevention and Treatment Center. Dr. Kotlarczyk is also a current Scholar of the Pittsburgh Claude D. Pepper Older Americans Independence Center. Her research focuses musculoskeletal health and physical function in older adults, particularly those residing in long-term care communities.

Advisory Committee Memberships and Leadership Positions• Member, Pittsburgh Claude D. Pepper Center Long-term Care Workgroup, 2015-present• Co-facilitator, Pittsburgh Claude D. Pepper Center Leadership and Cultural Coaching Workshop

Series for Junior Faculty, 2017-present• Member, Early Career Faculty Workgroup for the Pepper Older Americans Independence Center

(OAIC) Coordinating Center, 2018-present• Member, Pittsburgh Claude D. Pepper Center Muscle Aging Workgroup, 2019-present

Professional Affiliations and Society Memberships• Member, Osteoporosis Special Interest Group, American Geriatrics Society, 2016-present• Member, Junior Faculty Research Special Interest Group, American Geriatrics Society, 2017-

present

David A. Nace, MD, MPHDr. Nace is an Associate Professor of Medicine whose research focuses primarily on infectious disease in long-term care, particularly antimicrobial stewardship, vaccine preventable diseases, and outbreak prevention and response. He is the PI of the Improving Outcomes of UTI Management in LTC Study, an AHRQ funded dissemination and implementation project. As part of the IOU project Dr. Nace’s team developed guidelines for the diagnosis and treatment of uncomplicated cystitis in nursing home residents and is testing the implementation of these guidelines in a national cohort of nursing homes. Dr. Nace’s team received the AMDA/ABIM Choosing Wisely Campaign Award in March 2019 for this work. Dr. Nace is now leading work

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

• Technical Expert, “Developing a Patient Safety Culture Instrument for Nursing Home Use,” Westat Research Corporation, 2006-present

• Member, Health Information Technology (HIT) Subcommittee, American Medical Directors Association (AMDA), 2008-present

• Developer, Institute for Healthcare Improvement (IHI), Trigger Tool for Measuring Adverse Drug Events in the Nursing Home, 2009-present

• Technical Expert and Physician Lead, Physician and Patient Safety, Raising Awareness for Reducing Adverse Events in Nursing Homes Campaign, Centers for Medicare and Medicaid Services (CMS), 2014-present

• Safety Expert Panelist, Center for Medicare and Medicaid Services’ (CMS) Innovation Center, F-329 (Unnecessary Drugs) Guidance for State Surveyors Redesign Committee, 2012-present

• Member, Center for Medicare and Medicaid Services’ (CMS) Innovation Center, Enhanced Care and Coordination Provider (ECCP) Medical Director Council, 2013-present

• Member, Executive Committee for Quality Prescribing Campaign, AMDA/Society for Post-Acute and Long-Term Care, 2015-present

• Member, Taskforce on Quality Improvement in Nursing Home Regulation and Oversight, PA Dept. of Health, 2015-present

• Member, Framework Development to Support Measure Development for Telehealth, National Quality Foundation (NQF), 2016-present

• Member, Workgroup, Society for Post-Acute and Long-Term Care (AMDA), Telemedicine 2017-present

• Matter Expert, Subject telemedicine and co-author of Implementing Telehealth in Post-Acute and Long-Term Care Settings (PALTC), West Health Institute, 2019-present

Joseph T. Hanlon, PharmD, MSAn Emeritus Professor of Medicine, Dr. Hanlon is also a geriatric pharmacist and health scientist with both the Center for Health Equity Research and Promotion (CHERP) and the Geriatric Research Education and Clinical Center (GRECC) at the Pittsburgh VA. His research focuses on three themes: 1) drug-related problems, 2) racial disparities in medication use, and 3) drug-induced geriatric syndromes. He serves as a Co-I and Consultant on a number of federally funded grants and on the editorial boards of four journals.

Advisory Committee Memberships and Leadership Positions• Member, Geriatric Advisory Panel, “Modifying the Impact of ICU-Induced Neurological

Dysfunction-USA Study” (MIND-USA), Vanderbilt University, 2009-2018• Member, “Beers List” Updating Panel, American Geriatrics Society, 2011-present• Member, Technical Advisory Committee, PACE Program, Harrisburg, PA, 2012-2018• Consultant, VA funded Patient Safety Center of Inquiry: Safeguarding Ambulatory Care For

Veterans With Chronic Kidney Disease, 2016-2018• Consultant, “Addressing Behavior and Mood in Assisted Living: Organizational Characteristics

Related to the Use of Antipsychotic and Psychotropic Medications and Alternative Practices,” University of North Carolina-Chapel Hill, 2016-present

• Consultant, “Reducing High-Risk Geriatric Polypharmacy via EHR Nudges” (NIA funded R21), RAND Boston, 2017-present

• Consultant, “Pilot Study of Standardized Patient-Centered Medication Review (Spectorx) in Home Hospice” (NIA funded R21), UMASS-Worcester, 2018-present

Editorships• Editorial Board, Dementia Panel, Annals of Pharmacotherapy, 2003-present• Editorial Board, Journal of Gerontology: Medical Sciences, 2014-present• Editorial Board, Drugs and Aging, 2014-present• Editorial Board, Journal of American Medical Directors Association, 2018-present

Shuja Hassan, MDDr. Hassan provides primary care and consultative services to older adults at UPMC Senior Care-Shadyside. He is board certified in Internal Medicine and Geriatrics. Dr Hassan is also the Medical Director at UPMC Canterbury Place, a long-term care facility.

Advisory Committee Memberships and Leadership Positions• Associate Director, Geriatrics Rotation, UPMC Shadyside, 2004-present• Co-Director, Clinical Update in Geriatric Medicine CME Course, American Geriatrics Society

(Pennsylvania Chapter), University of Pittsburgh, 2009-presentMajor Lectureships and Seminars

• Presenter, Annual Clinical Update in Geriatric Medicine Conference, Pittsburgh, PA, May 2019Honors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Mary P. Kotlarczyk, PhDDr. Kotlarczyk is a Research Assistant Professor of Medicine and Associate Director of the Osteoporosis Prevention and Treatment Center. Dr. Kotlarczyk is also a current Scholar of the Pittsburgh Claude D. Pepper Older Americans Independence Center. Her research focuses musculoskeletal health and physical function in older adults, particularly those residing in long-term care communities.

Advisory Committee Memberships and Leadership Positions• Member, Pittsburgh Claude D. Pepper Center Long-term Care Workgroup, 2015-present• Co-facilitator, Pittsburgh Claude D. Pepper Center Leadership and Cultural Coaching Workshop

Series for Junior Faculty, 2017-present• Member, Early Career Faculty Workgroup for the Pepper Older Americans Independence Center

(OAIC) Coordinating Center, 2018-present• Member, Pittsburgh Claude D. Pepper Center Muscle Aging Workgroup, 2019-present

Professional Affiliations and Society Memberships• Member, Osteoporosis Special Interest Group, American Geriatrics Society, 2016-present• Member, Junior Faculty Research Special Interest Group, American Geriatrics Society, 2017-

present

David A. Nace, MD, MPHDr. Nace is an Associate Professor of Medicine whose research focuses primarily on infectious disease in long-term care, particularly antimicrobial stewardship, vaccine preventable diseases, and outbreak prevention and response. He is the PI of the Improving Outcomes of UTI Management in LTC Study, an AHRQ funded dissemination and implementation project. As part of the IOU project Dr. Nace’s team developed guidelines for the diagnosis and treatment of uncomplicated cystitis in nursing home residents and is testing the implementation of these guidelines in a national cohort of nursing homes. Dr. Nace’s team received the AMDA/ABIM Choosing Wisely Campaign Award in March 2019 for this work. Dr. Nace is now leading work

22

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

to develop a potential antibiotic stewardship quality measure that can be used by facilities and physicians. This would be the first quality measure that describes appropriateness of antibiotic prescribing as opposed to the existing crude utilization measures. This pilot work is being funded by the PA Department of Health. Dr. Nace is Co-PI on a CD-funded study evaluating the humoral and cellular response to the influenza vaccine in a cohort of adults 50 years and older by frailty status. He is also conducting a Pepper Center-funded pilot study to evaluate the impact of sarcopenia on humoral and cellular response among older adults. He serves as Co-Medical Director for our recently-renewed $39 million CMS Innovations Award project (RAVEN), which has developed innovative approaches to reducing unplanned hospital transfers from nursing homes. Finally, he collaborates with other Division researchers on a variety of NIH, AHRQ, and foundation-funded studies of older adults regarding infection control, osteoporosis, adverse drug events, palliative care, interprofessional training, and quality assessment and improvement.

Advisory Committee Memberships and Leadership Positions• Chair, PMDA Public Policy Committee, 1997-present• Abstract Reviewer, Gerontological Society of America, 1999-Present• Member, UPMC Influenza Task Force, 2004-Present• Member, UPMC Senior Communities Board of Directors, 2004-Present• Chair, UPMC Senior Communities PT Committee, 2006-Present• Member, UPMC Health System Infection Control Expert Work Group, 2009-Present• POLST Champion, PA POLST Coalition, 2010-present• Chair, Pennsylvania Dementia Care Partnership, 2012-present• Member, UPMC Health System PT Committee, 2012-Present• Member, Department of Medicine, Clinical Directors Council, 2012-Present• Vice Chair, AMDA Public Policy Committee, 2015-present• Curriculum Developer, AMDA, LTC CME Curriculum, 2015-present• Vice President, The Society of Post-Acute and LTC Medicine, AMDA, 2018-2019

Editorships• Manuscript Reviewer, American Journal of Geriatric Pharmacotherapy, 2004-Present• Manuscript Reviewer, Infection Control and Hospital Epidemiology, 2004-Present• Manuscript Reviewer, Vaccine, 2010-Present• Manuscript Reviewer, Annals of Internal Medicine, 2010-Present• Associate Editor, Journal of the American Medical Directors Association, 2017-present

Major Lectureships and Seminars

• Lecturer, Clinical Update in Geriatric Medicine, Pennsylvania Geriatrics Society, Pittsburgh, PA,2017-present

Honors and Awards• Honoree, Best Doctors in America, Best Doctors, Inc, 2009-present• Honoree, Best Doctors, Pittsburgh Magazine, 2009-present• Appointee, PA Governors Long-Term Care Council, Janauary 2019

Neelesh K. Nadkarni, MD, PhDAn Assistant Professor of Medicine and of Neurology at the School of Medicine, Dr. Nadkarni is a Principal Investigator of the study that examines the influence of Alzheimer's disease and cerebral small-vessel disease on walking, thinking, and cognitive-motor interactions in cognitively normal mobility unimpaired older adults.

He is also a PI on two pilot studies, one that examines the effect of cannabis on gait and cognition in older adults with chronic pain, and another on the relationship between cardiac amyloidosis and cerebral amyloidosis in healthy older adults. He is also co-investigator at the Alzheimer's Disease Research Center involved in several studies in Alzheimer's disease and actively collaborates with faculty in Neurology, Psychiatry, and Radiology in the School of Medicine, in the School of Rehabilitation Sciences, and in the Graduate School of Public Health at the University of Pittsburgh.

Anne B. Newman, MD, MPHDr. Newman is the Distinguished Professor and Chair of the Department of Epidemiology, with a secondary appointment as Professor of Medicine in Geriatrics. A member of NIH/NIA’s National Advisory Council on Aging, she is Principal Investigator for several large population studies and clinical trials and also serves as Director of the Center for Aging and Population Health at the Graduate School of Public Health. In addition, she collaborates with Dr. Greenspan as Co-PI of our Pepper Center, with Dr. Hanlon in the Health ABC Study, and with Dr. Nadkarni on the LIFE Study and the ENRGISE Study. Her research focuses on the factors associated with disability and healthy aging.

Advisory Committee Memberships and Leadership Positions• Member, Advisory Board, NIH/NIA Baltimore Longitudinal Study of Aging (BLSA), 2005-present• Member, Scientific Advisory Board, The Irish Longitudinal Study of Aging (TILDA), 2009-present• Member, External Advisory Committee, ALLHAT (Antihypertensive and Lipid-Lowering Treatment

to Prevent Heart Attack Trial), 2011-present• Member, External Advisory Committee, KURE (Korean Urban Rural Elderly) Study, 2012-present• Member, National Advisory Council on Aging (NACA), National Institute on Aging, 2014-present

Editorships• Editorial Board, Journal of Aging and Health, 2010-present• Editor-in-Chief, Journal of Gerontology: Medical Science, 2016-present

Elizabeth A. O'Keefe, MDDr. O'Keefe is an Associate Professor and Clinician-Educator with experience in many fields of Internal Medicine and Geriatrics derived from years of medical practice in the United Kingdom and South Africa. She has several publications relating to functional bowel disease in the elderly and has served as a reviewer for Journal of the American Geriatrics Society.

Advisory Committee Memberships and Leadership Positions• Organizer, CAMPC Clerkship Geriatrics Workshop, University of Pittsburgh, 2008-present• Co-Developer, Geriatric Survivor teaching module, Geriatrics (Macy) Course, University of

Pittsburgh, 2011-present• Coordinator, LTC session at Charles Morris, Geriatrics (Macy) Course, University of Pittsburgh,

2011-present• Member, Education Committee, University of Pittsburgh, 2014-present

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2013-present

David A. Pasquale, DODr. Pasquale provides geriatric primary care and consultative services at the Benedum Geriatric Center

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

to develop a potential antibiotic stewardship quality measure that can be used by facilities and physicians. This would be the first quality measure that describes appropriateness of antibiotic prescribing as opposed to the existing crude utilization measures. This pilot work is being funded by the PA Department of Health. Dr. Nace is Co-PI on a CD-funded study evaluating the humoral and cellular response to the influenza vaccine in a cohort of adults 50 years and older by frailty status. He is also conducting a Pepper Center-funded pilot study to evaluate the impact of sarcopenia on humoral and cellular response among older adults. He serves as Co-Medical Director for our recently-renewed $39 million CMS Innovations Award project (RAVEN), which has developed innovative approaches to reducing unplanned hospital transfers from nursing homes. Finally, he collaborates with other Division researchers on a variety of NIH, AHRQ, and foundation-funded studies of older adults regarding infection control, osteoporosis, adverse drug events, palliative care, interprofessional training, and quality assessment and improvement.

Advisory Committee Memberships and Leadership Positions• Chair, PMDA Public Policy Committee, 1997-present• Abstract Reviewer, Gerontological Society of America, 1999-Present• Member, UPMC Influenza Task Force, 2004-Present• Member, UPMC Senior Communities Board of Directors, 2004-Present• Chair, UPMC Senior Communities PT Committee, 2006-Present• Member, UPMC Health System Infection Control Expert Work Group, 2009-Present• POLST Champion, PA POLST Coalition, 2010-present• Chair, Pennsylvania Dementia Care Partnership, 2012-present• Member, UPMC Health System PT Committee, 2012-Present• Member, Department of Medicine, Clinical Directors Council, 2012-Present• Vice Chair, AMDA Public Policy Committee, 2015-present• Curriculum Developer, AMDA, LTC CME Curriculum, 2015-present• Vice President, The Society of Post-Acute and LTC Medicine, AMDA, 2018-2019

Editorships• Manuscript Reviewer, American Journal of Geriatric Pharmacotherapy, 2004-Present• Manuscript Reviewer, Infection Control and Hospital Epidemiology, 2004-Present• Manuscript Reviewer, Vaccine, 2010-Present• Manuscript Reviewer, Annals of Internal Medicine, 2010-Present• Associate Editor, Journal of the American Medical Directors Association, 2017-present

Major Lectureships and Seminars

• Lecturer, Clinical Update in Geriatric Medicine, Pennsylvania Geriatrics Society, Pittsburgh, PA, 2017-present

Honors and Awards• Honoree, Best Doctors in America, Best Doctors, Inc, 2009-present• Honoree, Best Doctors, Pittsburgh Magazine, 2009-present• Appointee, PA Governors Long-Term Care Council, Janauary 2019

Neelesh K. Nadkarni, MD, PhDAn Assistant Professor of Medicine and of Neurology at the School of Medicine, Dr. Nadkarni is a Principal Investigator of the study that examines the influence of Alzheimer's disease and cerebral small-vessel disease on walking, thinking, and cognitive-motor interactions in cognitively normal mobility unimpaired older adults.

He is also a PI on two pilot studies, one that examines the effect of cannabis on gait and cognition in older adults with chronic pain, and another on the relationship between cardiac amyloidosis and cerebral amyloidosis in healthy older adults. He is also co-investigator at the Alzheimer's Disease Research Center involved in several studies in Alzheimer's disease and actively collaborates with faculty in Neurology, Psychiatry, and Radiology in the School of Medicine, in the School of Rehabilitation Sciences, and in the Graduate School of Public Health at the University of Pittsburgh.

Anne B. Newman, MD, MPHDr. Newman is the Distinguished Professor and Chair of the Department of Epidemiology, with a secondary appointment as Professor of Medicine in Geriatrics. A member of NIH/NIA’s National Advisory Council on Aging, she is Principal Investigator for several large population studies and clinical trials and also serves as Director of the Center for Aging and Population Health at the Graduate School of Public Health. In addition, she collaborates with Dr. Greenspan as Co-PI of our Pepper Center, with Dr. Hanlon in the Health ABC Study, and with Dr. Nadkarni on the LIFE Study and the ENRGISE Study. Her research focuses on the factors associated with disability and healthy aging.

Advisory Committee Memberships and Leadership Positions• Member, Advisory Board, NIH/NIA Baltimore Longitudinal Study of Aging (BLSA), 2005-present• Member, Scientific Advisory Board, The Irish Longitudinal Study of Aging (TILDA), 2009-present• Member, External Advisory Committee, ALLHAT (Antihypertensive and Lipid-Lowering Treatment

to Prevent Heart Attack Trial), 2011-present• Member, External Advisory Committee, KURE (Korean Urban Rural Elderly) Study, 2012-present• Member, National Advisory Council on Aging (NACA), National Institute on Aging, 2014-present

Editorships• Editorial Board, Journal of Aging and Health, 2010-present• Editor-in-Chief, Journal of Gerontology: Medical Science, 2016-present

Elizabeth A. O'Keefe, MDDr. O'Keefe is an Associate Professor and Clinician-Educator with experience in many fields of Internal Medicine and Geriatrics derived from years of medical practice in the United Kingdom and South Africa. She has several publications relating to functional bowel disease in the elderly and has served as a reviewer for Journal of the American Geriatrics Society.

Advisory Committee Memberships and Leadership Positions• Organizer, CAMPC Clerkship Geriatrics Workshop, University of Pittsburgh, 2008-present• Co-Developer, Geriatric Survivor teaching module, Geriatrics (Macy) Course, University of

Pittsburgh, 2011-present• Coordinator, LTC session at Charles Morris, Geriatrics (Macy) Course, University of Pittsburgh,

2011-present• Member, Education Committee, University of Pittsburgh, 2014-present

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2013-present

David A. Pasquale, DODr. Pasquale provides geriatric primary care and consultative services at the Benedum Geriatric Center

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

located in UPMC Montefiore Hospital. Advisory Committee Memberships and Leadership Positions

• Member, Education Committee, University of Pittsburgh, 2018-presentHonors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Subashan Perera, PhDDr. Perera is a Professor of Medicine and Biostatistics with special interest in clinical trials, aging, time series analysis, item response theory, data mining, and predictive modeling. His work has involved estimating criteria for clinically meaningful change in physical performance measures of the elderly, examining their association with future outcomes using large data sets, and using item response theory to analyze rating scales used in elderly populations. Dr. Perera also co-leads the Data Management, Analysis, and Informatics Core of our Pepper Center, in addition to serving as co-investigator for multiple grants funded by the NIH, AHRQ, and within and outside of the Division.

Study Sections• Reviewer, Science Foundation Ireland President of Ireland Future Research, 2018

Advisory Committee Memberships and Leadership Positions• Member, External Data and Safety Monitoring Board Mechanistic Approach to Preventing

Atrophy and Restoring Function in Older Adults Trial (PI: Dreyer), 2014-present• Member, Data and Safety Monitoring Board Long-term effects of weight loss and supplemental

protein on physical function R01 AG050656, 2016-present• Member, Data and Safety Monitoring Board, Sedentary Time and Aging Research (STAR) Program

Project (P01 AG052352; PIs: Kerr & La Croix), 2017-present• Member, Pragmatic Clinical Studies Review Panel, Patient Centered Outcomes Research Institute,

2018• Member, NIDDK Urology and Nephrology Clinical Small Business Applications Special Emphasis

Panel, 2018-2019• Member, Data and Safety Monitoring Board, Hip Muscle Power, Lateral Balance Function, and

Falls in Aging (R01 AG060051; PI: Gray), 2018-2019

Eric G. Rodriguez, MD, MPHDr. Rodriguez is an Associate Professor of Medicine who serves as a Co-Investigator on grants related to the study of Alzheimer’s disease.

Advisory Committee Memberships and Leadership Positions• Rater, McMaster Online Rating of Evidence, 2014-present• Member, Advisory Committee, NIH Data and Safety Monitoring, Mindfulness, Education, and

Exercise for Cognitive Function study, 2016-presentHonors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2014-present• Honoree, Best Doctors in America, Best Doctors, Inc., 2014-present

Michelle I. Rossi, MD, MPHDr. Rossi's research focuses on appropriate medication use in older adults, chronic pain in older adults, and development and evaluation of new models of care in older adults (i.e., innovative models of dementia care

and driving safety assessment). Her teaching activities include a variety of clinical, didactic, and mentoring interactions with medical students, residents, and fellows, as well as teaching non-physician clinician trainees (nurse practitioner, physician assistant, psychology, pharmacy, speech therapy, occupational therapy, physical therapy, social work, speech therapy, audiology) in geriatric medicine topics. Dr. Rossi is the current Associate Director for Clinical Care with the GRECC of the VA Pittsburgh Healthcare System. She is the Director of the Geriatric Evaluation and Management (GEM) Clinic at the VA Pittsburgh Healthcare System, which is an interdisciplinary outpatient consultative clinic that provides frail older veterans with comprehensive geriatric assessment. She also directs the VA Dementia Clinic and the VA TeleDementia Clinic, which provide care to veterans with dementia and support to their families over the course of their illness. In addition, Dr. Rossi is Medical Director of the VA Geriatric Driving Safety Clinic, which uses an interdisciplinary team to assess driving safety in veterans with cognitive decline.

Advisory Committee Memberships and Leadership Positions• Director, Geriatrics Rotation, Internal Medicine residents, UPMC Presbyterian/MUH, 2009-present• Faculty and Planning Committee, VA Webinar Series for Homecare Nurses, other Home-based

Primary Care Team Members, 2012-present• Committee Member, VAPHS IRB, 2017-present

Fred H. Rubin, MDA Professor of Medicine, Dr. Rubin’s research has focused on evaluating the adaptability, sustainability, and impact of Dr. Sharon Inouye’s Hospital Elder Life Program (HELP). He has shown that it is as effective at preventing delirium at UPMC Shadyside, a large community-based hospital, as it was in the academic setting in which it was first developed and that it can decrease readmissions. By demonstrating both its efficacy and cost-savings, he has convinced hospital management to incorporate the program into its annual budget.

Advisory Committee Memberships and Leadership Positions• Program Director, Medicine Grand Rounds, UPMC Shadyside, 1992-present• Planning Committee, Update in Geriatric Medicine CME course, University of Pittsburgh, 1988-

present• Planning Committee, Update in Internal Medicine, University of Pittsburgh, 1999-present• President, Pennsylvania Geriatrics Society, Western Division, 2010-2018• Program Co-Director, 16th annual Internal Conference on the Hospital Elder Life Program (HELP),

2018Major Lectureships and Seminars

• Invited Lecturer, Update in Geriatric Medicine, Pittsburgh, PA, April 2019Honors and Awards

• Honoree, Top Doctors in America, Castle Connolly’s Guide to America’s Top Physicians, 2017-present

• Honoree, Best Doctors in America, Best Doctors, Inc., 2017-present• Honoree, Best Doctors in Pittsburgh, Pittsburgh Magazine, 2017-present

Leslie P. Scheunemann, MD, MPHAn Assistant Professor of Medicine with dual training in geriatrics and in pulmonary/critical care, Dr. Scheunemann receives support as a Pepper KL2 Scholar through the Geriatric Division’s NIA Pepper Grant. Her research focuses on developing and testing transitional care interventions to improve health, functioning, and quality of life among older adults who survive critical illness and their family caregivers.

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

located in UPMC Montefiore Hospital. Advisory Committee Memberships and Leadership Positions

• Member, Education Committee, University of Pittsburgh, 2018-presentHonors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Subashan Perera, PhDDr. Perera is a Professor of Medicine and Biostatistics with special interest in clinical trials, aging, time series analysis, item response theory, data mining, and predictive modeling. His work has involved estimating criteria for clinically meaningful change in physical performance measures of the elderly, examining their association with future outcomes using large data sets, and using item response theory to analyze rating scales used in elderly populations. Dr. Perera also co-leads the Data Management, Analysis, and Informatics Core of our Pepper Center, in addition to serving as co-investigator for multiple grants funded by the NIH, AHRQ, and within and outside of the Division.

Study Sections• Reviewer, Science Foundation Ireland President of Ireland Future Research, 2018

Advisory Committee Memberships and Leadership Positions• Member, External Data and Safety Monitoring Board Mechanistic Approach to Preventing

Atrophy and Restoring Function in Older Adults Trial (PI: Dreyer), 2014-present• Member, Data and Safety Monitoring Board Long-term effects of weight loss and supplemental

protein on physical function R01 AG050656, 2016-present• Member, Data and Safety Monitoring Board, Sedentary Time and Aging Research (STAR) Program

Project (P01 AG052352; PIs: Kerr & La Croix), 2017-present• Member, Pragmatic Clinical Studies Review Panel, Patient Centered Outcomes Research Institute,

2018• Member, NIDDK Urology and Nephrology Clinical Small Business Applications Special Emphasis

Panel, 2018-2019• Member, Data and Safety Monitoring Board, Hip Muscle Power, Lateral Balance Function, and

Falls in Aging (R01 AG060051; PI: Gray), 2018-2019

Eric G. Rodriguez, MD, MPHDr. Rodriguez is an Associate Professor of Medicine who serves as a Co-Investigator on grants related to the study of Alzheimer’s disease.

Advisory Committee Memberships and Leadership Positions• Rater, McMaster Online Rating of Evidence, 2014-present• Member, Advisory Committee, NIH Data and Safety Monitoring, Mindfulness, Education, and

Exercise for Cognitive Function study, 2016-presentHonors and Awards

• Honoree, Best Doctors, Pittsburgh Magazine, 2014-present• Honoree, Best Doctors in America, Best Doctors, Inc., 2014-present

Michelle I. Rossi, MD, MPHDr. Rossi's research focuses on appropriate medication use in older adults, chronic pain in older adults, and development and evaluation of new models of care in older adults (i.e., innovative models of dementia care

and driving safety assessment). Her teaching activities include a variety of clinical, didactic, and mentoring interactions with medical students, residents, and fellows, as well as teaching non-physician clinician trainees (nurse practitioner, physician assistant, psychology, pharmacy, speech therapy, occupational therapy, physical therapy, social work, speech therapy, audiology) in geriatric medicine topics. Dr. Rossi is the current Associate Director for Clinical Care with the GRECC of the VA Pittsburgh Healthcare System. She is the Director of the Geriatric Evaluation and Management (GEM) Clinic at the VA Pittsburgh Healthcare System, which is an interdisciplinary outpatient consultative clinic that provides frail older veterans with comprehensive geriatric assessment. She also directs the VA Dementia Clinic and the VA TeleDementia Clinic, which provide care to veterans with dementia and support to their families over the course of their illness. In addition, Dr. Rossi is Medical Director of the VA Geriatric Driving Safety Clinic, which uses an interdisciplinary team to assess driving safety in veterans with cognitive decline.

Advisory Committee Memberships and Leadership Positions• Director, Geriatrics Rotation, Internal Medicine residents, UPMC Presbyterian/MUH, 2009-present• Faculty and Planning Committee, VA Webinar Series for Homecare Nurses, other Home-based

Primary Care Team Members, 2012-present• Committee Member, VAPHS IRB, 2017-present

Fred H. Rubin, MDA Professor of Medicine, Dr. Rubin’s research has focused on evaluating the adaptability, sustainability, and impact of Dr. Sharon Inouye’s Hospital Elder Life Program (HELP). He has shown that it is as effective at preventing delirium at UPMC Shadyside, a large community-based hospital, as it was in the academic setting in which it was first developed and that it can decrease readmissions. By demonstrating both its efficacy and cost-savings, he has convinced hospital management to incorporate the program into its annual budget.

Advisory Committee Memberships and Leadership Positions• Program Director, Medicine Grand Rounds, UPMC Shadyside, 1992-present• Planning Committee, Update in Geriatric Medicine CME course, University of Pittsburgh, 1988-

present• Planning Committee, Update in Internal Medicine, University of Pittsburgh, 1999-present• President, Pennsylvania Geriatrics Society, Western Division, 2010-2018• Program Co-Director, 16th annual Internal Conference on the Hospital Elder Life Program (HELP),

2018Major Lectureships and Seminars

• Invited Lecturer, Update in Geriatric Medicine, Pittsburgh, PA, April 2019Honors and Awards

• Honoree, Top Doctors in America, Castle Connolly’s Guide to America’s Top Physicians, 2017-present

• Honoree, Best Doctors in America, Best Doctors, Inc., 2017-present• Honoree, Best Doctors in Pittsburgh, Pittsburgh Magazine, 2017-present

Leslie P. Scheunemann, MD, MPHAn Assistant Professor of Medicine with dual training in geriatrics and in pulmonary/critical care, Dr. Scheunemann receives support as a Pepper KL2 Scholar through the Geriatric Division’s NIA Pepper Grant. Her research focuses on developing and testing transitional care interventions to improve health, functioning, and quality of life among older adults who survive critical illness and their family caregivers.

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Advisory Committee Memberships and Leadership Positions• Member, Ethics and Conflicts of Interest Committee, American Thoracic Society, 2016-present• Member, Aging and Geriatrics Special Interest Committee, American Thoracic Society, 2017-

present• Member, Junior Faculty Research Group, American Geriatrics Society, 2017-present

Major Lectureships and Seminars• Presenter, Western PA Geriatrics Society Clinical Update, Pittsburgh, PA, 2016-present• Lecturer, ICU Survivorship Series, University of Pittsburgh Internal Medicine Residency, 2016-

present• Invited Ethics Discussant, New Jersey Thoracic Society Annual Meeting, 2018• Invited Lecturer, Geriatrics Annual Update, 2018• Invited Lecturer, Panther Grand Rounds, Department of Physical Medicine and Rehabilitation,

University of Pittsburgh, 2018• Invited Lecturer, Office for Advanced Practice Providers Fall 2018 CME Conference, Pittsburgh,

PA, 2018• Invited Lecturer, Department of Occupational Therapy, University of Pittsburgh, 2018-present

Honors and Awards• Health Services/Epidemiology Research Award, Department of Medicine Research Day, University

of Pittsburgh, April 2019

Stasa D. Tadic, MD, MSAn Associate Professor of Medicine, Dr. Tadic has remained involved in the study of geriatric urinary incontinence. Formerly supported by an NIA K23 Career Development Award, he is a member of the Geriatric Continence Research team (Drs. Resnick, Griffiths, and Clarkson). Although now more focused in the clinical arena, he continues to play a role in the group’s efforts.

Advisory Committee Memberships and Leadership Positions• Academic Chief, Geriatric Medicine, UPMC Mercy, 2015-present• Team Member and Co-Author, Delirium Progressive Medical Unit and Dementia Room QI

projects, Beckwith Institute, 2016-present

Adele L. Towers, MD, MPHDr. Towers's research interests are the study of healthcare financing and dementia prevention and treatment.

Study Sections• Member, Study Section, AHRQ HSQR, 2017-present

Major Lectureships and Seminars• Lecturer, Geriatric Medicine Workshops, University of Pittsburgh, 1990-present• Lecturer, Practicing Medicine, What Awaits You?, University of Pittsburgh, 2011-present• Preceptor, Benedum Geriatric Clinic, University of Pittsburgh Medical Center, 2018-2019• Invited Lecturer, Health 2.0 Conference, Panel Discussion, Santa Clara, CA, 2018• Invited Lecturer, RISE Conference, RISE Risk Adjustment Academy, Palm Springs, CA, 2018• Invited Lecturer, 11th Annual Risk Adjustment Forum for Medicare Advantage, Medicaid and

Commercial Plans, Fairmont Grand Del Mar, San Diego, CA, 2018• Invited Lecturer, RISE Conference, RISE Risk Adjustment Academy, Nashville, TN, March 2019• Invited Lecturer, Risk Adjustment Forum, Chicago, IL, 2019

• Presenter, Webinar, Natural Language Processing, Chilmark Research, 2019• Presenter, AHIP Webinar, 2019

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present• Top Doctor, 2018 Exceptional Women In Medicine, December 2018

Shachi Tyagi, MD, MSAn Assistant Professor of Medicine, Dr. Tyagi is supported by an NIH-R21 Grant. Her research interests include nocturia and geriatric insomnia, including their causes, treatment, and impact, both on each other and on the risk of falls.

Keisha Ward, MDDr. Ward provides geriatric primary care and consultative services at the Benedum Geriatric Center.

Professional Affiliations and Society Memberships• Member, American Geriatric Society, 2017-present• Member, Long Term Care Committee, Divison of Geriatrics, 2017-present

Debra K. Weiner, MDA Professor of Medicine with training in geriatrics, rheumatology, and acupuncture, Dr. Weiner researches chronic pain. She is PI of two VA Merit Review studies: 1) a multisite pilot study designed to improve management of chronic low back pain (CLBP) in older adults and 2) a multisite prospective cohort study to ascertain predictors of outcome in veterans undergoing decompressive laminectomy for lumbar spinal stenosis. She is PI (along with Dr. Neelesh Nadkarni) of a Pepper Center-funded pilot project evaluating the impact of medical marijuana on mobility and cognitive function in older adults. She also collaborates on NIH-funded studies that evaluate the contribution of hip osteoarthritis to pain and function in older adults with CLBP and that develop pain education programs for pre-professional students. Finally, she is Co-Director of the University of Pittsburgh's NIDA-funded Center of Excellence in Pain Education.

Study Sections• Ad Hoc Reviewer, Grant Applications, NIH, 2013-present

Advisory Committee Memberships and Leadership Positions• Member, Professional Advisory Board, American Chronic Pain Association, 2011-present• Member, Education Committee, Geriatric Medicine Division, UPMC, 2012-present• Co-Director, Center of Excellence in Pain Education, University of Pittsburgh, 2015-present• Co-Developer, Chronic Pain Management course, UPMC Houstaff, Internal Medicine, 2017-

present• Presenter, Internal Medicine Residency Interns, University of Pittsburgh, 2018-present• Acting Associate Director, Education and Evaluation, Geriatric Research, Education and Clinical

Center, VA Pittsburgh Healthcare System, 2018-presentEditorships

• Editorial Board, Pain Medicine, 2000-present• Senior Editor, Pain Medicine, 2011-present

Major Lectureships and Seminars• Lecturer, VA Scan-ECHO Virtual Pain Care Conference, 2018-present• Lecturer, VA Pittsburgh GRECC Interprofessional Trainees, 2018-present

27

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Advisory Committee Memberships and Leadership Positions• Member, Ethics and Conflicts of Interest Committee, American Thoracic Society, 2016-present• Member, Aging and Geriatrics Special Interest Committee, American Thoracic Society, 2017-

present• Member, Junior Faculty Research Group, American Geriatrics Society, 2017-present

Major Lectureships and Seminars• Presenter, Western PA Geriatrics Society Clinical Update, Pittsburgh, PA, 2016-present• Lecturer, ICU Survivorship Series, University of Pittsburgh Internal Medicine Residency, 2016-

present• Invited Ethics Discussant, New Jersey Thoracic Society Annual Meeting, 2018• Invited Lecturer, Geriatrics Annual Update, 2018• Invited Lecturer, Panther Grand Rounds, Department of Physical Medicine and Rehabilitation,

University of Pittsburgh, 2018• Invited Lecturer, Office for Advanced Practice Providers Fall 2018 CME Conference, Pittsburgh,

PA, 2018• Invited Lecturer, Department of Occupational Therapy, University of Pittsburgh, 2018-present

Honors and Awards• Health Services/Epidemiology Research Award, Department of Medicine Research Day, University

of Pittsburgh, April 2019

Stasa D. Tadic, MD, MSAn Associate Professor of Medicine, Dr. Tadic has remained involved in the study of geriatric urinary incontinence. Formerly supported by an NIA K23 Career Development Award, he is a member of the Geriatric Continence Research team (Drs. Resnick, Griffiths, and Clarkson). Although now more focused in the clinical arena, he continues to play a role in the group’s efforts.

Advisory Committee Memberships and Leadership Positions• Academic Chief, Geriatric Medicine, UPMC Mercy, 2015-present• Team Member and Co-Author, Delirium Progressive Medical Unit and Dementia Room QI

projects, Beckwith Institute, 2016-present

Adele L. Towers, MD, MPHDr. Towers's research interests are the study of healthcare financing and dementia prevention and treatment.

Study Sections• Member, Study Section, AHRQ HSQR, 2017-present

Major Lectureships and Seminars• Lecturer, Geriatric Medicine Workshops, University of Pittsburgh, 1990-present• Lecturer, Practicing Medicine, What Awaits You?, University of Pittsburgh, 2011-present• Preceptor, Benedum Geriatric Clinic, University of Pittsburgh Medical Center, 2018-2019• Invited Lecturer, Health 2.0 Conference, Panel Discussion, Santa Clara, CA, 2018• Invited Lecturer, RISE Conference, RISE Risk Adjustment Academy, Palm Springs, CA, 2018• Invited Lecturer, 11th Annual Risk Adjustment Forum for Medicare Advantage, Medicaid and

Commercial Plans, Fairmont Grand Del Mar, San Diego, CA, 2018• Invited Lecturer, RISE Conference, RISE Risk Adjustment Academy, Nashville, TN, March 2019• Invited Lecturer, Risk Adjustment Forum, Chicago, IL, 2019

• Presenter, Webinar, Natural Language Processing, Chilmark Research, 2019• Presenter, AHIP Webinar, 2019

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present• Top Doctor, 2018 Exceptional Women In Medicine, December 2018

Shachi Tyagi, MD, MSAn Assistant Professor of Medicine, Dr. Tyagi is supported by an NIH-R21 Grant. Her research interests include nocturia and geriatric insomnia, including their causes, treatment, and impact, both on each other and on the risk of falls.

Keisha Ward, MDDr. Ward provides geriatric primary care and consultative services at the Benedum Geriatric Center.

Professional Affiliations and Society Memberships• Member, American Geriatric Society, 2017-present• Member, Long Term Care Committee, Divison of Geriatrics, 2017-present

Debra K. Weiner, MDA Professor of Medicine with training in geriatrics, rheumatology, and acupuncture, Dr. Weiner researches chronic pain. She is PI of two VA Merit Review studies: 1) a multisite pilot study designed to improve management of chronic low back pain (CLBP) in older adults and 2) a multisite prospective cohort study to ascertain predictors of outcome in veterans undergoing decompressive laminectomy for lumbar spinal stenosis. She is PI (along with Dr. Neelesh Nadkarni) of a Pepper Center-funded pilot project evaluating the impact of medical marijuana on mobility and cognitive function in older adults. She also collaborates on NIH-funded studies that evaluate the contribution of hip osteoarthritis to pain and function in older adults with CLBP and that develop pain education programs for pre-professional students. Finally, she is Co-Director of the University of Pittsburgh's NIDA-funded Center of Excellence in Pain Education.

Study Sections• Ad Hoc Reviewer, Grant Applications, NIH, 2013-present

Advisory Committee Memberships and Leadership Positions• Member, Professional Advisory Board, American Chronic Pain Association, 2011-present• Member, Education Committee, Geriatric Medicine Division, UPMC, 2012-present• Co-Director, Center of Excellence in Pain Education, University of Pittsburgh, 2015-present• Co-Developer, Chronic Pain Management course, UPMC Houstaff, Internal Medicine, 2017-

present• Presenter, Internal Medicine Residency Interns, University of Pittsburgh, 2018-present• Acting Associate Director, Education and Evaluation, Geriatric Research, Education and Clinical

Center, VA Pittsburgh Healthcare System, 2018-presentEditorships

• Editorial Board, Pain Medicine, 2000-present• Senior Editor, Pain Medicine, 2011-present

Major Lectureships and Seminars• Lecturer, VA Scan-ECHO Virtual Pain Care Conference, 2018-present• Lecturer, VA Pittsburgh GRECC Interprofessional Trainees, 2018-present

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

TEACHING ACTIVITIES

Division faculty members teach trainees at every level, from high school student to practicing physician. In addition to the training noted in the research section, we also teach advanced practice providers and trainees in pharmacy, nursing, psychology, chaplaincy, physical/occupational therapy, and social work.

Medical StudentsLed by Dr. Wright, we teach an innovative and required week-long interprofessional geriatrics course for more than 200 students from the schools of medicine (MS-3), nursing, dentistry, pharmacy, and allied health (OT, PT, Speech, Social Work, Nutrition & Dietetics, and PAs). Evaluation shows improved knowledge, attitudes, and skills in geriatric medicine and team-based practices. In addition, Drs. Scheunemann and Resnick direct a novel Geriatrics Area of Concentration, which enables medical students to “major” in geriatrics (12 in FY19). In FY19, Drs. Greenspan and Wright mentored three medical students, whose projects resulted in two David Martin awards and five poster presentations at local and national conferences. Finally, we sponsor scholarly projects for three to seven students/year, many of whom are funded by our T32.

Medical ResidentsWe teach a required month-long geriatrics experience in the clinic, home, hospital, and nursing home settings for all UPMC PUH and Mercy residents in internal medicine. For FY20, the residency agreed to revise the PUH residency program: all interns will spend two weeks on the geriatrics consult service and all PGY2 residents will spend a month with us, split between our geriatric hospitalist service and our outpatient and SNF practices. Led by Dr. Wright, we also offer an innovative Geriatrics Track that allows four to nine residents to “major” in geriatrics; these residents base their continuity clinic in geriatrics and also care for panels of homebound patients. Dr. Wright has also created four advanced geriatrics rotations which attracted three additional Track and non-Track residents. Several of these innovations have been featured at national AGS meetings, including the “Roadmap,” milestones, and pharmacology QI projects, as well as a new curriculum to teach residents how to communicate and work with patients and families living with dementia.

Geriatric Medicine FellowshipIn FY19 we trained four clinical fellows, including a board-certified cardiologist who completed an innovative training track in geriatric cardiology in preparation for an academic career. Our geriatric-palliative care fellow is completing her training program, which includes an integrative scholarly project, and our academic-track fellow completed her Masters in Medical Education and has accepted an academic position. We also recruited four excellent fellows for FY20.

• Presenter, 27th Annual Clinical Update in Geriatric Medicine, Pittsburgh PA, 2018• Course Director, Pittsburgh Pain Practicum, VA GeriScholars Program, 2018-present• Presenter, Department of Physical Medicine & Rehabilitation Grand Rounds, University of Texas

Southwestern, Dallas TX, 2018

Rollin M. Wright, MD, MA, MPHAn Assistant Professor of Medicine, Dr. Wright's interests as a clinician educator include curriculum development and evaluation in geriatric medicine, education research, advanced dementia, interprofessional education, terminal decline, and skilled and long-term care. Her education research is funded by a HRSA Geriatric Workforce Enhancement Program (GWEP) grant.

Advisory Committee Memberships and Leadership Positions• Assistant Chair, American Medical Directors Association Annual Program Planning Committee,

2014-present• Course Director, Interprofessional Geriatrics Week, October 2015-present• Project Director, HRSA Geriatric Workforce Enhancement Program Project 3 (Advanced Dementia

Communication Competency), 2015-2018• Chair, Education Committee, Division of Geriatric Medicine, University of Pittsburgh, 2015-present• Chair, Awards Committee, Pennsylvania Geriatrics Society-Western Division, 2016-Present

Major Lectureships and Seminars• Invited lecturer, University of Pittsburgh Annual Medical Ethics Conference, University of

Pittsburgh, March 2019• Symposium Speaker, 2019 AMDA-PALTC annual conference, Atlanta, GA, March 2019• Invited Lecturer, Pennsylvania Medical Society Update in Internal Medicine, Pittsburgh, PA, April

2019• Invited Lecturer, UPMC Mercy Geriatric Clinical Update, UPMC Mercy Hospital, May 2019

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

T h e D i v i s i o n h o s t sa n a n n u a l C M E c o u r s e

t h a t a t t r a c t e d o v e r

and rece ived anat iona l awardfrom the Amer icanGer iatr ics Soc iety

400 in 2019attendees

29

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

TEACHING ACTIVITIES

Division faculty members teach trainees at every level, from high school student to practicing physician. In addition to the training noted in theresearch section, we also teach advanced practice providers and trainees in pharmacy, nursing, psychology, chaplaincy, physical/occupational therapy, and social work.

Medical StudentsLed by Dr. Wright, we teach an innovative and required week-long interprofessional geriatrics course for more than 200 students from the schools of medicine (MS-3), nursing, dentistry, pharmacy, and allied health (OT, PT, Speech, Social Work, Nutrition & Dietetics, and PAs). Evaluation shows improved knowledge, attitudes, and skills in geriatric medicine and team-based practices. In addition, Drs. Scheunemann and Resnick direct a novel Geriatrics Area of Concentration, which enables medical students to “major” in geriatrics (12 in FY19). In FY19, Drs. Greenspan and Wright mentored three medical students, whose projects resulted in two David Martin awards and five poster presentations at local and national conferences. Finally, we sponsor scholarly projects for three to seven students/year, many of whom are funded by our T32.

Medical ResidentsWe teach a required month-long geriatrics experience in the clinic, home, hospital, and nursing home settings for all UPMC PUH and Mercy residents in internal medicine. For FY20, the residency agreed to revise the PUH residency program: all interns will spend two weeks on the geriatrics consult service and all PGY2 residents will spend a month with us, split between our geriatric hospitalist service and our outpatient and SNF practices. Led by Dr. Wright, we also offer an innovative Geriatrics Track that allows four to nine residents to “major” in geriatrics; these residents base their continuity clinic in geriatrics and also care for panels of homebound patients. Dr. Wright has also created four advanced geriatrics rotations which attracted three additional Track and non-Track residents. Several of these innovations have been featured at national AGS meetings, including the “Roadmap,” milestones, and pharmacology QI projects, as well as a new curriculum to teach residents how to communicate and work with patients and families living with dementia.

Geriatric Medicine FellowshipIn FY19 we trained four clinical fellows, including a board-certified cardiologist who completed an innovative training track in geriatric cardiology in preparation for an academic career. Our geriatric-palliative care fellow is completing her training program, which includes an integrative scholarly project, and our academic-track fellow completed her Masters in Medical Education and has accepted an academic position. We also recruited four excellent fellows for FY20.

• Presenter, 27th Annual Clinical Update in Geriatric Medicine, Pittsburgh PA, 2018• Course Director, Pittsburgh Pain Practicum, VA GeriScholars Program, 2018-present• Presenter, Department of Physical Medicine & Rehabilitation Grand Rounds, University of Texas

Southwestern, Dallas TX, 2018

Rollin M. Wright, MD, MA, MPHAn Assistant Professor of Medicine, Dr. Wright's interests as a clinician educator include curriculum development and evaluation in geriatric medicine, education research, advanced dementia, interprofessional education, terminal decline, and skilled and long-term care. Her education research is funded by a HRSA Geriatric Workforce Enhancement Program (GWEP) grant.

Advisory Committee Memberships and Leadership Positions• Assistant Chair, American Medical Directors Association Annual Program Planning Committee,

2014-present• Course Director, Interprofessional Geriatrics Week, October 2015-present• Project Director, HRSA Geriatric Workforce Enhancement Program Project 3 (Advanced Dementia

Communication Competency), 2015-2018• Chair, Education Committee, Division of Geriatric Medicine, University of Pittsburgh, 2015-present• Chair, Awards Committee, Pennsylvania Geriatrics Society-Western Division, 2016-Present

Major Lectureships and Seminars• Invited lecturer, University of Pittsburgh Annual Medical Ethics Conference, University of

Pittsburgh, March 2019• Symposium Speaker, 2019 AMDA-PALTC annual conference, Atlanta, GA, March 2019• Invited Lecturer, Pennsylvania Medical Society Update in Internal Medicine, Pittsburgh, PA, April

2019• Invited Lecturer, UPMC Mercy Geriatric Clinical Update, UPMC Mercy Hospital, May 2019

Honors and Awards• Honoree, Best Doctors, Pittsburgh Magazine, 2016-present

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

T h e D i v i s i o n h o s t sa n a n n u a l C M E c o u r s e

t h a t a t t r a c t e d o v e r

and rece ived anat iona l awardfrom the Amer icanGer iatr ics Soc iety

400 in 2019attendees

30

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

In FY19, the geriatric medicine and psychiatry fellowships embraced and embedded a longitudinal curriculum developed by Dr. Wright to teach fellows how to work with people and families living with dementia and how to lead team-based dementia behavior problem solving in the long-term care setting. Five fellows presented final projects to improve the challenging dementia behaviors of five patients they followed during the fellowship year. Dr. Wright presented this curriculum at the 2019 AMDA-PALTC conference.

Dr. Wright also mentored Rachel Jantea, our first T32 education fellow. Dr. Jantea completed a Masters of Science in Medical Education as well as a research project in which she designed, implemented, and evaluated an innovative curriculum designed to teach interprofessional teamwork to health sciences students rotating through her Interprofessional Dedicated Education Unit (IPDEU) at PUH. She also presented this at two national conferences.

Advanced Practice Provider StudentsWe continue to train both Physician Assistant and CRNP students in acute care geriatrics.

High School Students (University of Pittsburgh Health Scholars Academy)The Division teaches in this highly competitive—and highly rated—summer program on aging; 25 elite high school students from throughout Pennsylvania are selected to participate each year.

Continuing Medical Education (CME)Recognized by a national award from AGS, this year our annual CME course again attracted 400 attendees from more than 20 states. Dr. Greenspan continues to teach programs on osteoporosis which she helped to create for the American Academy of Family Medicine, ISCD, and the National Osteoporosis Foundation. Several faculty led “Meet the Professor” sessions at national meetings (e.g., ACP, AGS).

OtherOur faculty author chapters on aging for major textbooks, including Cecil’s (Resnick; Greenspan), UpToDate (Weiner), Braunwald’s The Heart (Forman), and DiPiro’s Pharmacotherapy: A Pathophysiologic Approach (Hanlon). Division faculty have also developed geriatric curricula for surgical subspecialties, including ENT, urology, and gynecology.

Clinical Fellows, FY2019

Current FellowsNivedita Gunturi, MDMedical School: Sri Ramachandra University, IndiaResidency: UPMC

Departing FellowsAlison O'Donnell, DO, MPHMedical School: Philadelphia College of Osteopathic MedicineResidency: Allegheny Health Network, Pittsburgh, PACurrent Position: Private Practice

Deirdre O'Neill Vailas, MD, MS

Medical School: University of AlbertaResidency: University of AlbertaCurrent Position: Assistant Professor, Department of Medicine, Division of Cardiology, University of Alberta

Pratik Pandit, MDMedical School: Florida State University College of MedicineResidency: Saint Louis UniversityCurrent Position: Physician, Jacksonville, FL

Fellow ActivitiesAlison O'Donnell, DO, MPH

Presentations and Abstracts• O’Donnell A, Rana S, “Management of bone pain from ‘metastatic’ sarcoidosis,” Department of

Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019• O’Donnell A, Pandit P, Bowers K, Naumovski J, “Dirty Urine: A Brief Intervention to Decrease

Urine Culture Contamination Rates,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to use fluoroquinolones more judiciously?,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to use fluoroquinolones more judiciously?,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

• O’Donnell A, Rana S, “Management of bone pain from ‘metastatic’ sarcoidosis,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

• Naumovski J, Pandit P, O’Donnell A, Bucci L, “Once again: ‘treat the patient not the laboratory’ – A case of Pseudohypoglycemia,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

Deirdre O'Neill Vailas, MD, MSPresentations and Abstracts

• Vailas DE, Rossi MI, “A case of Lyme Neuroborreliosis,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

Awards• Detweiler Traveling Fellowship Award, Royal College of Physicians and Surgeons of Canada, July

2018

Geriatrics Fellowship, Class of 2019 with Karen E. Glasser Scandrett, MD, fellowship director and Linda Eazor, fellowship coordinator.

31

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

In FY19, the geriatric medicine and psychiatry fellowships embraced and embedded a longitudinal curriculum developed by Dr. Wright to teach fellows how to work with people and families living with dementia and how to lead team-based dementia behavior problem solving in the long-term care setting. Five fellows presented final projects to improve the challenging dementia behaviors of five patients they followed during the fellowship year. Dr. Wright presented this curriculum at the 2019 AMDA-PALTC conference.

Dr. Wright also mentored Rachel Jantea, our first T32 education fellow. Dr. Jantea completed a Masters of Science in Medical Education as well as a research project in which she designed, implemented, and evaluated an innovative curriculum designed to teach interprofessional teamwork to health sciences students rotating through her Interprofessional Dedicated Education Unit (IPDEU) at PUH. She also presented this at two national conferences.

Advanced Practice Provider StudentsWe continue to train both Physician Assistant and CRNP students in acute care geriatrics.

High School Students (University of Pittsburgh Health Scholars Academy)The Division teaches in this highly competitive—and highly rated—summer program on aging; 25 elite high school students from throughout Pennsylvania are selected to participate each year.

Continuing Medical Education (CME)Recognized by a national award from AGS, this year our annual CME course again attracted 400 attendees from more than 20 states. Dr. Greenspan continues to teach programs on osteoporosis which she helped to create for the American Academy of Family Medicine, ISCD, and the National Osteoporosis Foundation. Several faculty led “Meet the Professor” sessions at national meetings (e.g., ACP, AGS).

OtherOur faculty author chapters on aging for major textbooks, including Cecil’s (Resnick; Greenspan), UpToDate(Weiner), Braunwald’s The Heart (Forman), and DiPiro’s Pharmacotherapy: A Pathophysiologic Approach(Hanlon). Division faculty have also developed geriatric curricula for surgical subspecialties, including ENT, urology, and gynecology.

Clinical Fellows, FY2019

Current FellowsNivedita Gunturi, MDMedical School: Sri Ramachandra University, IndiaResidency: UPMC

Departing FellowsAlison O'Donnell, DO, MPHMedical School: Philadelphia College of Osteopathic MedicineResidency: Allegheny Health Network, Pittsburgh, PACurrent Position: Private Practice

Deirdre O'Neill Vailas, MD, MS

Medical School: University of AlbertaResidency: University of AlbertaCurrent Position: Assistant Professor, Department of Medicine, Division of Cardiology, University of Alberta

Pratik Pandit, MDMedical School: Florida State University College of MedicineResidency: Saint Louis UniversityCurrent Position: Physician, Jacksonville, FL

Fellow ActivitiesAlison O'Donnell, DO, MPH

Presentations and Abstracts• O’Donnell A, Rana S, “Management of bone pain from ‘metastatic’ sarcoidosis,” Department of

Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019• O’Donnell A, Pandit P, Bowers K, Naumovski J, “Dirty Urine: A Brief Intervention to Decrease

Urine Culture Contamination Rates,” Department of Medicine Research Day, University ofPittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to usefluoroquinolones more judiciously?,” Department of Medicine Research Day, University ofPittsburgh, Pittsburgh, PA, April 2019

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,”Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to usefluoroquinolones more judiciously?,” American Geriatrics Society Annual National Meeting,Portland, OR, May 2019

• O’Donnell A, Rana S, “Management of bone pain from ‘metastatic’ sarcoidosis,” AmericanGeriatrics Society Annual National Meeting, Portland, OR, May 2019

• Naumovski J, Pandit P, O’Donnell A, Bucci L, “Once again: ‘treat the patient not the laboratory’ –A case of Pseudohypoglycemia,” American Geriatrics Society Annual National Meeting, Portland,OR, May 2019

Deirdre O'Neill Vailas, MD, MSPresentations and Abstracts

• Vailas DE, Rossi MI, “A case of Lyme Neuroborreliosis,” American Geriatrics Society AnnualNational Meeting, Portland, OR, May 2019

Awards• Detweiler Traveling Fellowship Award, Royal College of Physicians and Surgeons of Canada, July

2018

Geriatrics Fellowship, Class of 2019 with Karen E. Glasser Scandrett, MD, fellowship director and Linda Eazor, fellowship coordinator.

32

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Pratik Pandit, MDPresentations and Abstracts

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,”Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “Dirty Urine: A Brief Intervention to DecreaseUrine Culture Contamination Rates,” Department of Medicine Research Day, University ofPittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves touse fluoroquinolones more judiciously?,” Department of Medicine Research Day, University ofPittsburgh, Pittsburgh, PA, April 2019

• Naumovski J, Pandit P, O’Donnell A, Bucci L, “Once again: ‘treat the patient not the laboratory’ –A case of Pseudohypoglycemia,” American Geriatrics Society Annual National Meeting, Portland,OR, May 2019

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,”American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to usefluoroquinolones more judiciously?,” American Geriatrics Society Annual National Meeting,Portland, OR, May 2019

Postdoctoral Fellows, FY2019

Rachel Jantea, MDMentors: Rollin Wright, MD, MA, MPH, and Debra Weiner, MD Dr. Jantea designed a collaborative-practice curriculum for health profession students and providers caring for older adults on a neurological trauma unit at UPMC. She is studying its impact on educational and healthcare outcomes.

THREE-YEAR BIBLIOGRAPHY

Neil M. Resnick, MD Division Chief

Clarkson BD, Karim HT, Griffiths DJ, Resnick NM. Functional connectivity of the brain in older women with urgency urinary incontinence. Neurourol Urodyn. 2018 Nov;37(8):2763-2775.

Clarkson BD, Griffiths D, Resnick NM. Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence? Neurourol Urodyn. 2018 Nov;37(8):2597-2605.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Castle N, Resnick N. Service-Enriched Housing: The Staying at Home Program. J Appl Gerontol. 2016 Aug;35(8):857-77.

Namita S. Ahuja-Yende, MDBellon JE, Bilderback A, Ahuja-Yende NS, Wilson C, Altieri Dunn SC, Brodine D, Boninger ML. University of Pittsburgh Medical Center Home Transitions Multidisciplinary Care Coordination Reduces Readmissions for Older Adults. J Am Geriatr Soc. 2019 Jan;67(1):156-163.

Becky D. Clarkson, PhDClarkson BD, Karim HT, Griffiths DJ, Resnick NM. Functional connectivity of the brain in older women with urgency urinary incontinence. Neurourol Urodyn. 2018 Nov;37(8):2763-2775.

Clarkson BD, Griffiths D, Resnick NM. Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence? Neurourol Urodyn. 2018 Nov;37(8):2597-2605.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Pratik Pandit, MDPresentations and Abstracts

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “Dirty Urine: A Brief Intervention to Decrease Urine Culture Contamination Rates,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to use fluoroquinolones more judiciously?,” Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA, April 2019

• Naumovski J, Pandit P, O’Donnell A, Bucci L, “Once again: ‘treat the patient not the laboratory’ – A case of Pseudohypoglycemia,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

• Pandit P, O’Donnell A, Hurst A, Naumovski J, “Daylight saving time and nursing home falls,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

• O’Donnell A, Pandit P, Bowers K, Naumovski J, “How often do we have to remind ourselves to use fluoroquinolones more judiciously?,” American Geriatrics Society Annual National Meeting, Portland, OR, May 2019

Postdoctoral Fellows, FY2019

Rachel Jantea, MDMentors: Rollin Wright, MD, MA, MPH, and Debra Weiner, MD Dr. Jantea designed a collaborative-practice curriculum for health profession students and providers caring for older adults on a neurological trauma unit at UPMC. She is studying its impact on educational and healthcare outcomes.

THREE-YEAR BIBLIOGRAPHY

Neil M. Resnick, MD Division Chief

Clarkson BD, Karim HT, Griffiths DJ, Resnick NM. Functional connectivity of the brain in older women with urgency urinary incontinence. Neurourol Urodyn. 2018 Nov;37(8):2763-2775.

Clarkson BD, Griffiths D, Resnick NM. Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence? Neurourol Urodyn. 2018 Nov;37(8):2597-2605.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Castle N, Resnick N. Service-Enriched Housing: The Staying at Home Program. J Appl Gerontol. 2016 Aug;35(8):857-77.

Namita S. Ahuja-Yende, MDBellon JE, Bilderback A, Ahuja-Yende NS, Wilson C, Altieri Dunn SC, Brodine D, Boninger ML. University of Pittsburgh Medical Center Home Transitions Multidisciplinary Care Coordination Reduces Readmissions for Older Adults. J Am Geriatr Soc. 2019 Jan;67(1):156-163.

Becky D. Clarkson, PhDClarkson BD, Karim HT, Griffiths DJ, Resnick NM. Functional connectivity of the brain in older women with urgency urinary incontinence. Neurourol Urodyn. 2018 Nov;37(8):2763-2775.

Clarkson BD, Griffiths D, Resnick NM. Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence? Neurourol Urodyn. 2018 Nov;37(8):2597-2605.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

34

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Body Composition Study Population. Circ Heart Fail. 2017 Sep;10(9).

McIntosh N, Fix GM, Allsup K, Charns M, McDannold S, Manning K, Forman DE. A Qualitative Study of Participation in Cardiac Rehabilitation Programs in an Integrated Healthcare System. Mil Med. 2017 Sep;182(9):e1757-e1763.

Damluji AA, Cohen ER, Moscucci M, Myerburg RJ, Cohen MG, Brooks MM, Rich MW, Forman DE. Insulin Provision Therapy and Mortality in Older Adults with Diabetes Mellitus and Stable Ischemic Heart Disease: Insights from BARI-2D Trial. Int J Cardiol. 2017 Aug 15;241:35-40.

Pandey A, Khan H, Newman AB, Lakatta EG, Forman DE, Butler J, Berry JD. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction; The Health ABC Study (Health, Aging, and Body Composition). Hypertension. 2017 Feb;69(2):267-74.

Williams VJ, Hayes JP, Forman DE, Salat DH, Sperling RA, Verfaellie M, Hayes SM. Cardiorespiratory Fitness is Differentially Associated with Cortical Thickness in Young and Older Adults. NeuroImage. 2017 Feb 1;146:1084-92.

Skaar E, Ranhoff AH, Nordrehaug JE, Forman DE, Schaufel MA. Conditions for Autonomous Choice: A Qualitative Study of Older Adults' Experience of Decision-Making in TAVR. J Geriatr Cardiol. 2017 Jan;14(1):42-8.

Jhamb M, McNulty ML, Ingalsbe G, Childers JW, Schell J, Conroy MB, Forman DE, Hergenroeder A, Dew MA. Knowledge, Barriers and Facilitators of Exercise in Dialysis Patients: A Qualitative Study of Patients, Staff and Nephrologists. BMC Nephrol. 2016 Nov 24;17(1):192.

Ó Hartaigh B, Lovato LC, Pahor M, Buford TW, Dodson JA, Forman DE, Buman MP, Demons JL, Santanasto AJ, Liu C, Miller ME, McDermott MM, Gill TM; LIFE Study Group. Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2016 Dec;64(12):2511-16.

Krishnaswami A, Go AS, Forman DE, Leong TK, Lee H, Maurer MS, McCulloch CE. Multimorbidity is strongly associated with long-term but not short-term mortality after cardiac valve replacement. Int J Cardiol. 2016 Jul 15;215:417-21.

Amelia S. Gennari, MD

Howerton M, Suhrie E, Jones N, Gennari A and Ruby CM. Evaluation of direct oral anticoagulant dosing and monitoring in two geriatric outpatient clinics. The Senior Care Pharmacist. 2019 Mar;34(3):192-205.

Susan L. Greenspan, MDAlqahtani BA, Sparto PJ, Whitney SL, Greenspan SL, Perera S, Brach JS. Psychometric Properties of Lower Extremity Strength Measurements Recorded in Community Settings in Independent Living Older Adults. Exp Aging Res. 2019 May-Jun;45(3):282-292.

Nayak S, Greenspan SL. A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk. Osteoporos Int. 2019 Apr;30(4):705-720.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Daniel E. Forman, MDDodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005320.

Damluji AA, Bandeen-Roche K, Berkower C, Boyd CM, Al-Damluji MS, Cohen MG, Forman DE, Chaudhary R, Gerstenblith G, Walston JD, Resar JR, Moscucci M. Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock. J Am Coll Cardiol. 2019 Apr 23;73(15):1890-1900.

Santos M, West E, Skali H, Forman DE, Nadruz W Junior, Shah AM. Resting Heart Rate and Chronotropic Response to Exercise: Prognostic Implications in Heart Failure Across the Left Ventricular Ejection Fraction Spectrum. J Card Fail. 2018 Nov;24(11):753-762.

Skaar E, Eide LSP, Norekvål TM, Ranhoff AH, Nordrehaug JE, Forman DE, Schoenenberger AW, Hufthammer KO, Kuiper KK, Bleie Ø, Packer EJS, Langørgen J, Haaverstad R, Schaufel MA. A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation. Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):153-160.

Krishnaswami A, Kim DH, McCulloch CE, Forman DE, Maurer MS, Alexander KP, Rich MW. Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial. Am J Med. 2018 Oct;131(10):1220-1227.e1.

Nadruz W Jr, West E, Sengeløv M, Grove GL, Santos M, Groarke JD, Forman DE, Claggett B, Skali H, Nohria A, Shah AM. Cardiovascular phenotype and prognosis of patients with heart failure induced by cancer therapy. Heart. 2019 Jan;105(1):34-41.

Edmiston E, Dolansky MA, Zullo M, Forman DE. Octogenarians' post-acute care use after cardiac valve surgery and recovery: clinical implications. Geriatr Nurs. 2018 Jul - Aug;39(4):371-375.

Cavalcante JL, Rijal S, Abdelkarim I, Althouse AD, Sharbaugh MS, Fridman Y, Soman P, Forman DE, Schindler JT, Gleason TG, Lee JS, Schelbert EB. Cardiac Amyloidosis Is Prevalent in Older Patients with Aortic Stenosis and Carries Worse Prognosis. J Cardiovasc Magn Reson. 2017 Dec 7;19(1):98.

Nadruz W Jr, West E, Sengeløv M, Santos M, Groarke JD, Forman DE, Claggett B, Skali H, Shah AM. Prognostic Value of Cardiopulmonary Exercise Testing in Heart Failure With Reduced, Midrange, and Preserved Ejection Fraction. J Am Heart Assoc. 2017 Oct 31;6(11).

Lam PH, Dooley DJ, Fonarow GC, Butler J, Bhatt DL, Filippatos GS, Deedwania P, Forman DE. White M, Fletcher RD, Arundel C, Blackman MR, Adamopoulos C, Kanonidis IE, Aban IB, Ptel K, Aronow WS, Allman RM, Anker SD, Pitt P, Ahmed A. Similar Clinical Benefits From Below-target- and Target-dose Enalapril in Patients with Heart Failure in the SOLVD Treatment Trial. Eur J Heart Fail. 2018 Feb;20(2):359-369.

Forman DE, Santanasto AJ, Boudreau RM, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AM. Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and

35

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Body Composition Study Population. Circ Heart Fail. 2017 Sep;10(9).

McIntosh N, Fix GM, Allsup K, Charns M, McDannold S, Manning K, Forman DE. A Qualitative Study of Participation in Cardiac Rehabilitation Programs in an Integrated Healthcare System. Mil Med. 2017 Sep;182(9):e1757-e1763.

Damluji AA, Cohen ER, Moscucci M, Myerburg RJ, Cohen MG, Brooks MM, Rich MW, Forman DE. Insulin Provision Therapy and Mortality in Older Adults with Diabetes Mellitus and Stable Ischemic Heart Disease: Insights from BARI-2D Trial. Int J Cardiol. 2017 Aug 15;241:35-40.

Pandey A, Khan H, Newman AB, Lakatta EG, Forman DE, Butler J, Berry JD. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction; The Health ABC Study (Health, Aging, and Body Composition). Hypertension. 2017 Feb;69(2):267-74.

Williams VJ, Hayes JP, Forman DE, Salat DH, Sperling RA, Verfaellie M, Hayes SM. Cardiorespiratory Fitness is Differentially Associated with Cortical Thickness in Young and Older Adults. NeuroImage. 2017 Feb 1;146:1084-92.

Skaar E, Ranhoff AH, Nordrehaug JE, Forman DE, Schaufel MA. Conditions for Autonomous Choice: A Qualitative Study of Older Adults' Experience of Decision-Making in TAVR. J Geriatr Cardiol. 2017 Jan;14(1):42-8.

Jhamb M, McNulty ML, Ingalsbe G, Childers JW, Schell J, Conroy MB, Forman DE, Hergenroeder A, Dew MA. Knowledge, Barriers and Facilitators of Exercise in Dialysis Patients: A Qualitative Study of Patients, Staff and Nephrologists. BMC Nephrol. 2016 Nov 24;17(1):192.

Ó Hartaigh B, Lovato LC, Pahor M, Buford TW, Dodson JA, Forman DE, Buman MP, Demons JL, Santanasto AJ, Liu C, Miller ME, McDermott MM, Gill TM; LIFE Study Group. Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2016 Dec;64(12):2511-16.

Krishnaswami A, Go AS, Forman DE, Leong TK, Lee H, Maurer MS, McCulloch CE. Multimorbidity is strongly associated with long-term but not short-term mortality after cardiac valve replacement. Int J Cardiol. 2016 Jul 15;215:417-21.

Amelia S. Gennari, MD

Howerton M, Suhrie E, Jones N, Gennari A and Ruby CM. Evaluation of direct oral anticoagulant dosing and monitoring in two geriatric outpatient clinics. The Senior Care Pharmacist. 2019 Mar;34(3):192-205.

Susan L. Greenspan, MDAlqahtani BA, Sparto PJ, Whitney SL, Greenspan SL, Perera S, Brach JS. Psychometric Properties of Lower Extremity Strength Measurements Recorded in Community Settings in Independent Living Older Adults. Exp Aging Res. 2019 May-Jun;45(3):282-292.

Nayak S, Greenspan SL. A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk. Osteoporos Int. 2019 Apr;30(4):705-720.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Daniel E. Forman, MDDodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Goldstein D, Forman DE, Alexander KP, Gill TM, Chaudhry SI. Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005320.

Damluji AA, Bandeen-Roche K, Berkower C, Boyd CM, Al-Damluji MS, Cohen MG, Forman DE, Chaudhary R, Gerstenblith G, Walston JD, Resar JR, Moscucci M. Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock. J Am Coll Cardiol. 2019 Apr 23;73(15):1890-1900.

Santos M, West E, Skali H, Forman DE, Nadruz W Junior, Shah AM. Resting Heart Rate and Chronotropic Response to Exercise: Prognostic Implications in Heart Failure Across the Left Ventricular Ejection Fraction Spectrum. J Card Fail. 2018 Nov;24(11):753-762.

Skaar E, Eide LSP, Norekvål TM, Ranhoff AH, Nordrehaug JE, Forman DE, Schoenenberger AW, Hufthammer KO, Kuiper KK, Bleie Ø, Packer EJS, Langørgen J, Haaverstad R, Schaufel MA. A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation. Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):153-160.

Krishnaswami A, Kim DH, McCulloch CE, Forman DE, Maurer MS, Alexander KP, Rich MW. Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial. Am J Med. 2018 Oct;131(10):1220-1227.e1.

Nadruz W Jr, West E, Sengeløv M, Grove GL, Santos M, Groarke JD, Forman DE, Claggett B, Skali H, Nohria A, Shah AM. Cardiovascular phenotype and prognosis of patients with heart failure induced by cancer therapy. Heart. 2019 Jan;105(1):34-41.

Edmiston E, Dolansky MA, Zullo M, Forman DE. Octogenarians' post-acute care use after cardiac valve surgery and recovery: clinical implications. Geriatr Nurs. 2018 Jul - Aug;39(4):371-375.

Cavalcante JL, Rijal S, Abdelkarim I, Althouse AD, Sharbaugh MS, Fridman Y, Soman P, Forman DE, Schindler JT, Gleason TG, Lee JS, Schelbert EB. Cardiac Amyloidosis Is Prevalent in Older Patients with Aortic Stenosis and Carries Worse Prognosis. J Cardiovasc Magn Reson. 2017 Dec 7;19(1):98.

Nadruz W Jr, West E, Sengeløv M, Santos M, Groarke JD, Forman DE, Claggett B, Skali H, Shah AM. Prognostic Value of Cardiopulmonary Exercise Testing in Heart Failure With Reduced, Midrange, and Preserved Ejection Fraction. J Am Heart Assoc. 2017 Oct 31;6(11).

Lam PH, Dooley DJ, Fonarow GC, Butler J, Bhatt DL, Filippatos GS, Deedwania P, Forman DE. White M, Fletcher RD, Arundel C, Blackman MR, Adamopoulos C, Kanonidis IE, Aban IB, Ptel K, Aronow WS, Allman RM, Anker SD, Pitt P, Ahmed A. Similar Clinical Benefits From Below-target- and Target-dose Enalapril in Patients with Heart Failure in the SOLVD Treatment Trial. Eur J Heart Fail. 2018 Feb;20(2):359-369.

Forman DE, Santanasto AJ, Boudreau RM, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AM. Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and

36

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Sciamanna C, Ballentine NH, Bopp M, Brach JS, Chinchilli VM, Ciccolo JT, Conroy MB, Fisher A, Fox EJ, Greenspan SL, Jan De Beur Suzanne M, Kearcher K, Kraschnewski JL, McTigue KM, McAuley E, Morone NE, Paranjape A, Rodriguez-Colon S, Rosenzweig A, Smyth JM, Stewart KJ, Stuckey HL. Working to Increase Stability through Exercise (WISE): Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries. Contemp Clin Trials. 2018 Nov;74:1-10.

Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Sep;33(9):1612-1621.

Nayak S, Greenspan SL. How Can We Improve Osteoporosis Care? A Systematic Review and Meta-Analysis of the Efficacy of Quality Improvement Strategies for Osteoporosis. J Bone Miner Res. 2018 Sep;33(9):1585-1594.

Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1053-1061.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Danila MI, Outman RC, Rahn EJ, Mudano AS, Redden DT, Li P, Allison JJ, Anderson FA, Wyman A, Greenspan SL, LaCroix AZ, Nieves JW, Silverman SL, Siris ES, Watts NB, Miller MJ, Curtis JR, Warriner AH, Wright NC, Saag KG. Evaluation of a Multimodal, Direct-to-Patient Educational Intervention Targeting Barriers to Osteoporosis Care: A Randomized Clinical Trial. J Bone Miner Res. 2018 May;33(5):763-772.

Geusens P, Marin F, Kendler DL, Russo LA, Zerbini CA, Minisola S, Body JJ, Lespessailles E, Greenspan SL, Bagur A, Stepan JJ, Lakatos P, Casado E, Moericke R, López-Romero P, Fahrleitner-Pammer A. Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial. J Bone Miner Res. 2018 May;33(5):783-794.

Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018 May;15(5):615-621.

Greenspan SL, Singer A, Vujevich K, Marchand B, Thompson DA, Hsu YJ, Vaidya D, Stern LS, Zeldow D, Lee DB, Karp S, Recker R. Implementing a fracture liaison service open model of care utilizing a cloud-based tool. Osteoporos Int. 2018 Apr;29(4):953-960.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S. Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur. Osteoporos Int. 2018

Feb;29(2):501-506.

Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2018 Jan 20;391(10117):230-240. Erratum in: Lancet. 2018 Dec 1;392(10162):2352.

Litwic AE, Compston JE, Wyman A, Siris ES, Gehlbach SH, Adachi JD, Chapurlat R, Díez-Pérez A, LaCroix AZ, Nieves JW, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Silverman S, Watts NB, Greenspan SL, March L, Gregson CL, Cooper C, Dennison EM; Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators. Self-perception of fracture risk: what can it tell us? Osteoporos Int. 2017 Dec;28(12):3495-3500.

Huppert TJ, Karim H, Lin CC, Alqahtani BA, Greenspan SL, Sparto PJ. Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy. PLoS One. 2017 Oct 12;12(10):e0184918.

Alqahtani BA, Ferchak MA, Huppert TJ, Sejdic E, Perera S, Greenspan SL, Sparto PJ. Standing balance and strength measurements in older adults living in residential care communities. Aging Clin Exp Res. 2017 Oct;29(5):1021-1030.

Khalid AT, Moore CG, Hall C, Olabopo F, Rozario NL, Holick MF, Greenspan SL, Rajakumar K. Utility of sun-reactive skin typing and melanin index for discerning vitamin D deficiency. Pediatr Res. 2017 Sep;82(3):444-451.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Nayak S, Greenspan SL. Osteoporosis Treatment Efficacy for Men: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2017 Mar;65(3):490-495.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Danila MI, Outman RC, Rahn EJ, Mudano AS, Thomas TF, Redden DT, Allison JJ, Anderson FA, Anderson JP, Cram PM, Curtis JR, Fraenkel L, Greenspan SL, LaCroix AZ, Majumdar SR, Miller MJ, Nieves JW, Safford MM, Silverman SL, Siris ES, Solomon DH, Warriner AH, Watts NB, Yood RA, Saag KG. A multi-modal intervention for Activating Patients at Risk for Osteoporosis (APROPOS): Rationale, design, and uptake of online study intervention material. Contemp Clin Trials Commun. 2016 Dec 15;4:14-24.

Chalhoub D, Orwoll ES, Cawthon PM, Ensrud KE, Boudreau R, Greenspan S, Newman AB, Zmuda J, Bauer D,

37

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Sciamanna C, Ballentine NH, Bopp M, Brach JS, Chinchilli VM, Ciccolo JT, Conroy MB, Fisher A, Fox EJ, Greenspan SL, Jan De Beur Suzanne M, Kearcher K, Kraschnewski JL, McTigue KM, McAuley E, Morone NE, Paranjape A, Rodriguez-Colon S, Rosenzweig A, Smyth JM, Stewart KJ, Stuckey HL. Working to Increase Stability through Exercise (WISE): Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries. Contemp Clin Trials. 2018 Nov;74:1-10.

Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Sep;33(9):1612-1621.

Nayak S, Greenspan SL. How Can We Improve Osteoporosis Care? A Systematic Review and Meta-Analysis of the Efficacy of Quality Improvement Strategies for Osteoporosis. J Bone Miner Res. 2018 Sep;33(9):1585-1594.

Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1053-1061.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Danila MI, Outman RC, Rahn EJ, Mudano AS, Redden DT, Li P, Allison JJ, Anderson FA, Wyman A, Greenspan SL, LaCroix AZ, Nieves JW, Silverman SL, Siris ES, Watts NB, Miller MJ, Curtis JR, Warriner AH, Wright NC, Saag KG. Evaluation of a Multimodal, Direct-to-Patient Educational Intervention Targeting Barriers to Osteoporosis Care: A Randomized Clinical Trial. J Bone Miner Res. 2018 May;33(5):763-772.

Geusens P, Marin F, Kendler DL, Russo LA, Zerbini CA, Minisola S, Body JJ, Lespessailles E, Greenspan SL, Bagur A, Stepan JJ, Lakatos P, Casado E, Moericke R, López-Romero P, Fahrleitner-Pammer A. Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial. J Bone Miner Res. 2018 May;33(5):783-794.

Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018 May;15(5):615-621.

Greenspan SL, Singer A, Vujevich K, Marchand B, Thompson DA, Hsu YJ, Vaidya D, Stern LS, Zeldow D, Lee DB, Karp S, Recker R. Implementing a fracture liaison service open model of care utilizing a cloud-based tool. Osteoporos Int. 2018 Apr;29(4):953-960.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S. Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur. Osteoporos Int. 2018

Feb;29(2):501-506.

Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2018 Jan 20;391(10117):230-240. Erratum in: Lancet. 2018 Dec 1;392(10162):2352.

Litwic AE, Compston JE, Wyman A, Siris ES, Gehlbach SH, Adachi JD, Chapurlat R, Díez-Pérez A, LaCroix AZ, Nieves JW, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Silverman S, Watts NB, Greenspan SL, March L, Gregson CL, Cooper C, Dennison EM; Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators. Self-perception of fracture risk: what can it tell us? Osteoporos Int. 2017 Dec;28(12):3495-3500.

Huppert TJ, Karim H, Lin CC, Alqahtani BA, Greenspan SL, Sparto PJ. Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy. PLoS One. 2017 Oct 12;12(10):e0184918.

Alqahtani BA, Ferchak MA, Huppert TJ, Sejdic E, Perera S, Greenspan SL, Sparto PJ. Standing balance and strength measurements in older adults living in residential care communities. Aging Clin Exp Res. 2017 Oct;29(5):1021-1030.

Khalid AT, Moore CG, Hall C, Olabopo F, Rozario NL, Holick MF, Greenspan SL, Rajakumar K. Utility of sun-reactive skin typing and melanin index for discerning vitamin D deficiency. Pediatr Res. 2017 Sep;82(3):444-451.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Nayak S, Greenspan SL. Osteoporosis Treatment Efficacy for Men: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2017 Mar;65(3):490-495.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Danila MI, Outman RC, Rahn EJ, Mudano AS, Thomas TF, Redden DT, Allison JJ, Anderson FA, Anderson JP, Cram PM, Curtis JR, Fraenkel L, Greenspan SL, LaCroix AZ, Majumdar SR, Miller MJ, Nieves JW, Safford MM, Silverman SL, Siris ES, Solomon DH, Warriner AH, Watts NB, Yood RA, Saag KG. A multi-modal intervention for Activating Patients at Risk for Osteoporosis (APROPOS): Rationale, design, and uptake of online study intervention material. Contemp Clin Trials Commun. 2016 Dec 15;4:14-24.

Chalhoub D, Orwoll ES, Cawthon PM, Ensrud KE, Boudreau R, Greenspan S, Newman AB, Zmuda J, Bauer D,

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Cummings S, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Areal and volumetric bone mineral density and risk of multiple types of fracture in older men. Bone. 2016 Nov;92:100-106.

Prasad C, Greenspan SL, Vujevich KT, Brufsky A, Lembersky BC, van Londen GJ, Jankowitz RC, Puhalla SL, Rastogi P, Perera S. Risedronate may preserve bone microarchitecture in breast cancer survivors on aromatase inhibitors: A randomized, controlled clinical trial. Bone. 2016 Sep;90:123-6.

Rajakumar K, Moore CG, Yabes J, Olabopo F, Haralam MA, Comer D, Holick MF, Greenspan SL. Estimations of dietary vitamin D requirements in black and white children. Pediatr Res. 2016 Jul;80(1):14-20.

Compston JE, Wyman A, FitzGerald G, Adachi JD, Chapurlat RD, Cooper C, Díez-Pérez A, Gehlbach SH, Greenspan SL, Hooven FH, LaCroix AZ, March L, Netelenbos JC, Nieves JW, Pfeilschifter J, Rossini M, Roux C, Saag KG, Siris ES, Silverman S, Watts NB, Anderson FA Jr. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res. 2016 Jul;31(7):1466-72.

Aditi U. Gurkar, PhDGurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3-mediated stress responses acceleratesoxidative DNA damage induced aging. Redox Biol. 2018 Sep;18:191-199.

Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU., McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radical Biol Med. 2018 Aug 20;124:79-96.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence and aging. Redox Biol. 2018 Jul;17:259-273.

Steven M. Handler, MD, PhDDriessen J, Chang W, Patel P, Wright RM, Ernst K, Handler SM. Nursing Home Provider Perceptions of Telemedicine for Providing Specialty Consults. Telemed J E Health. 2018 Jul;24(7):510-516.

Driessen J, Castle NG, Handler SM. Perceived Benefits, Barriers, and Drivers of Telemedicine From the Perspective of Skilled Nursing Facility Administrative Staff Stakeholders. J Appl Gerontol. 2018 Jan;37(1):110-120.

Pruskowski J, Handler SM. The DE-PHARM Project: A Pharmacist-Driven Deprescribing Initiative in a Nursing Facility. Consult Pharm. 2017 Aug 1;32(8):468-478.

Kane-Gill SL, Niznik JD, Kellum JA, Culley CM, Boyce RD, Marcum ZA, He H, Perera S, Handler SM. Use of Telemedicine to Enhance Pharmacist Services in the Nursing Facility. Consult Pharm. 2017 Feb 1;32(2):93-98.

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing Home Data from Multiple

Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252.

Jiang Y, Sereika SM, DeVito Dabbs A, Handler SM, Schlenk EA. Using mobile health technology to deliver decision support for self-monitoring after lung transplantation. Int J Med Inform. 2016 Oct;94:164-71.

Smith KJ, Handler SM, Kapoor WN, Martich GD, Reddy VK, Clark S. Automated Communication Tools and Computer-Based Medication Reconciliation to Decrease Hospital Discharge Medication Errors. Am J Med Qual. 2016 Jul;31(4):315-22.

Joseph T. Hanlon, PharmD, MSYum B, Archambault A, Levitan EB, Dharamdasani T, Kneifati-Hayek J, Hanlon JT, Diaz I, Maurer MS, Lachs MS, Safford MM, Goyal P. Indications for β-Blocker Prescriptions in Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2019 Jul;67(7):1461-1466.

Radomski TR, Zhao X, Hanlon JT, Thorpe JM, Thorpe CT, Naples JG, Sileanu FE, Cashy JP, Hale JA, Mor MK, Hausmann LRM, Donohue JM, Suda KJ, Stroupe KT, Good CB, Fine MJ, Gellad WF. Use of a medication-based risk adjustment index to predict mortality among veterans dually-enrolled in VA and medicare. Healthc (Amst). 2019 Apr 25.

Moyo P, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Donohue JM, Hausmann LRM, Hanlon JT, Good CB, Fine MJ, Gellad WF. Dual Receipt of Prescription Opioids From the Department of Veterans Affairs and Medicare Part D and Prescription Opioid Overdose Death Among Veterans: A Nested Case-Control Study. Ann Intern Med. 2019 Apr 2;170(7):433-442.

Moyo P, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Donohue JM, Hausmann LRM, Hanlon JT, Good CB, Fine MJ, Gellad WF. Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans. Res Social Adm Pharm. 2019 Aug;15(8):1007-1013.

Schleiden LJ, Thorpe CT, Cashy JP, Gellad WF, Good CB, Hanlon JT, Mor MK, Niznik JD, Pleis JR, Van Houtven CH, Thorpe JM. Characteristics of dual drug benefit use among veterans with dementia enrolled in the Veterans Health Administration and Medicare Part D. Res Social Adm Pharm. 2019 Jun;15(6):701-709.

Aspinall SL, Springer SP, Zhao X, Cunningham FE, Thorpe CT, Semla TP, Shorr RI, Hanlon JT. Central Nervous System Medication Burden and Risk of Recurrent Serious Falls and Hip Fractures in Veterans Affairs Nursing Home Residents. J Am Geriatr Soc. 2019 Jan;67(1):74-80.

Niznik JD, Zhang S, Mor MK, Zhao X, Ersek M, Aspinall SL, Gellad WF, Thorpe JM, Hanlon JT, Schleiden LJ, Springer S, Thorpe CT. Adaptation and Initial Validation of Minimum Data Set (MDS) Mortality Risk Index to MDS Version 3.0. J Am Geriatr Soc. 2018 Dec;66(12):2353-2359.

Thorpe CT, Gellad WF, Mor MK, Cashy JP, Pleis JR, Van Houtven CH, Schleiden LJ, Hanlon JT, Niznik JD, Carico RL Jr, Good CB, Thorpe JM. Effect of Dual Use of Veterans Affairs and Medicare Part D Drug Benefits on Antihypertensive Medication Supply in a National Cohort of Veterans with Dementia. Health Serv Res. 2018 Dec;53 Suppl 3:5375-5401.

Carico R, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Hausmann LRM, Donohue JM, Suda KJ, Stroupe K, Hanlon JT, Good CB, Fine MJ, Gellad WF. Receipt of Overlapping

39

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Cummings S, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Areal and volumetric bone mineral density and risk of multiple types of fracture in older men. Bone. 2016 Nov;92:100-106.

Prasad C, Greenspan SL, Vujevich KT, Brufsky A, Lembersky BC, van Londen GJ, Jankowitz RC, Puhalla SL, Rastogi P, Perera S. Risedronate may preserve bone microarchitecture in breast cancer survivors on aromatase inhibitors: A randomized, controlled clinical trial. Bone. 2016 Sep;90:123-6.

Rajakumar K, Moore CG, Yabes J, Olabopo F, Haralam MA, Comer D, Holick MF, Greenspan SL. Estimations of dietary vitamin D requirements in black and white children. Pediatr Res. 2016 Jul;80(1):14-20.

Compston JE, Wyman A, FitzGerald G, Adachi JD, Chapurlat RD, Cooper C, Díez-Pérez A, Gehlbach SH, Greenspan SL, Hooven FH, LaCroix AZ, March L, Netelenbos JC, Nieves JW, Pfeilschifter J, Rossini M, Roux C, Saag KG, Siris ES, Silverman S, Watts NB, Anderson FA Jr. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res. 2016 Jul;31(7):1466-72.

Aditi U. Gurkar, PhDGurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3-mediated stress responses acceleratesoxidative DNA damage induced aging. Redox Biol. 2018 Sep;18:191-199.

Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU., McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radical Biol Med. 2018 Aug 20;124:79-96.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence and aging. Redox Biol. 2018 Jul;17:259-273.

Steven M. Handler, MD, PhDDriessen J, Chang W, Patel P, Wright RM, Ernst K, Handler SM. Nursing Home Provider Perceptions of Telemedicine for Providing Specialty Consults. Telemed J E Health. 2018 Jul;24(7):510-516.

Driessen J, Castle NG, Handler SM. Perceived Benefits, Barriers, and Drivers of Telemedicine From the Perspective of Skilled Nursing Facility Administrative Staff Stakeholders. J Appl Gerontol. 2018 Jan;37(1):110-120.

Pruskowski J, Handler SM. The DE-PHARM Project: A Pharmacist-Driven Deprescribing Initiative in a Nursing Facility. Consult Pharm. 2017 Aug 1;32(8):468-478.

Kane-Gill SL, Niznik JD, Kellum JA, Culley CM, Boyce RD, Marcum ZA, He H, Perera S, Handler SM. Use of Telemedicine to Enhance Pharmacist Services in the Nursing Facility. Consult Pharm. 2017 Feb 1;32(2):93-98.

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing Home Data from Multiple

Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252.

Jiang Y, Sereika SM, DeVito Dabbs A, Handler SM, Schlenk EA. Using mobile health technology to deliver decision support for self-monitoring after lung transplantation. Int J Med Inform. 2016 Oct;94:164-71.

Smith KJ, Handler SM, Kapoor WN, Martich GD, Reddy VK, Clark S. Automated Communication Tools and Computer-Based Medication Reconciliation to Decrease Hospital Discharge Medication Errors. Am J Med Qual. 2016 Jul;31(4):315-22.

Joseph T. Hanlon, PharmD, MSYum B, Archambault A, Levitan EB, Dharamdasani T, Kneifati-Hayek J, Hanlon JT, Diaz I, Maurer MS, Lachs MS, Safford MM, Goyal P. Indications for β-Blocker Prescriptions in Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2019 Jul;67(7):1461-1466.

Radomski TR, Zhao X, Hanlon JT, Thorpe JM, Thorpe CT, Naples JG, Sileanu FE, Cashy JP, Hale JA, Mor MK, Hausmann LRM, Donohue JM, Suda KJ, Stroupe KT, Good CB, Fine MJ, Gellad WF. Use of a medication-based risk adjustment index to predict mortality among veterans dually-enrolled in VA and medicare. Healthc (Amst). 2019 Apr 25.

Moyo P, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Donohue JM, Hausmann LRM, Hanlon JT, Good CB, Fine MJ, Gellad WF. Dual Receipt of Prescription Opioids From the Department of Veterans Affairs and Medicare Part D and Prescription Opioid Overdose Death Among Veterans: A Nested Case-Control Study. Ann Intern Med. 2019 Apr 2;170(7):433-442.

Moyo P, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Donohue JM, Hausmann LRM, Hanlon JT, Good CB, Fine MJ, Gellad WF. Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans. Res Social Adm Pharm. 2019 Aug;15(8):1007-1013.

Schleiden LJ, Thorpe CT, Cashy JP, Gellad WF, Good CB, Hanlon JT, Mor MK, Niznik JD, Pleis JR, Van Houtven CH, Thorpe JM. Characteristics of dual drug benefit use among veterans with dementia enrolled in the Veterans Health Administration and Medicare Part D. Res Social Adm Pharm. 2019 Jun;15(6):701-709.

Aspinall SL, Springer SP, Zhao X, Cunningham FE, Thorpe CT, Semla TP, Shorr RI, Hanlon JT. Central Nervous System Medication Burden and Risk of Recurrent Serious Falls and Hip Fractures in Veterans Affairs Nursing Home Residents. J Am Geriatr Soc. 2019 Jan;67(1):74-80.

Niznik JD, Zhang S, Mor MK, Zhao X, Ersek M, Aspinall SL, Gellad WF, Thorpe JM, Hanlon JT, Schleiden LJ, Springer S, Thorpe CT. Adaptation and Initial Validation of Minimum Data Set (MDS) Mortality Risk Index to MDS Version 3.0. J Am Geriatr Soc. 2018 Dec;66(12):2353-2359.

Thorpe CT, Gellad WF, Mor MK, Cashy JP, Pleis JR, Van Houtven CH, Schleiden LJ, Hanlon JT, Niznik JD, Carico RL Jr, Good CB, Thorpe JM. Effect of Dual Use of Veterans Affairs and Medicare Part D Drug Benefits on Antihypertensive Medication Supply in a National Cohort of Veterans with Dementia. Health Serv Res. 2018 Dec;53 Suppl 3:5375-5401.

Carico R, Zhao X, Thorpe CT, Thorpe JM, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Hausmann LRM, Donohue JM, Suda KJ, Stroupe K, Hanlon JT, Good CB, Fine MJ, Gellad WF. Receipt of Overlapping

40

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Opioid and Benzodiazepine Prescriptions Among Veterans Dually Enrolled in Medicare Part D and the Department of Veterans Affairs: A Cross-sectional Study. Ann Intern Med. 2018 Nov 6;169(9):593-601.

Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. J Am Med Dir Assoc. 2018 Sep;19(9):765-769.e3.

Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW, Ensrud K, Cauley JA; Study of Osteoporotic Fractures (SOF) Research Group. Anxiety symptoms and risk of dementia and mild cognitive impairment in the oldest old women. Aging Ment Health. 2018 Apr;22(4):474-482.

Gellad WF, Thorpe JM, Zhao X, Thorpe CT, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Hausmann LRM, Donohue JM, Gordon AJ, Suda KJ, Stroupe KT, Hanlon JT, Cunningham FE, Good CB, Fine MJ. Impact of Dual Use of Department of Veterans Affairs and Medicare Part D Drug Benefits on Potentially Unsafe Opioid Use. Am J Public Health. 2018 Feb;108(2):248-255.

Gray SL, Hart LA, Perera S, Semla TP, Schmader KE, Hanlon JT. Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc. 2018 Feb;66(2):282-288.

Sagawa N, Marcum ZA, Boudreau RM, Hanlon JT, Albert SM, O'Hare C, Satterfield S, Schwartz AV, Vinik AI, Cauley JA, Harris TB, Newman AB, Strotmeyer ES; Health Aging Body Composition Study. Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study. Eur J Ageing. 2018 Jan 19;15(3):321-330.

Niznik J, Zhao X, Jiang T, Hanlon JT, Aspinall SL, Thorpe J, Thorpe C. Anticholinergic Prescribing in Medicare Part D Beneficiaries Residing in Nursing Homes: Results from a Retrospective Cross-Sectional Analysis of Medicare Data. Drugs Aging. 2017 Dec;34(12):925-939.

Jasuja GK, Bhasin S, Rose AJ, Reisman JI, Hanlon JT, Miller DR, Morreale AP, Pogach LM, Cunningham FE, Park A, Wiener RS, Gifford AL, Berlowitz DR. Provider and Site-Level Determinants of Testosterone Prescribing in the Veterans Healthcare System. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3226-3233.

Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Anxiety symptoms and risk of cognitive decline in older community-dwelling men. Int Psychogeriatr. 2017 Jul;29(7):1137-1145.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Jasuja GK, Bhasin S, Reisman JI, Hanlon JT, Miller DR, Morreale AP, Pogach LM, Cunningham FE, Park A, Berlowitz DR, Rose AJ. Who Gets Testosterone? Patient Characteristics Associated with Testosterone Prescribing in the Veteran Affairs System: a Cross-Sectional Study. J Gen Intern Med. 2017 Mar;32(3):304-311.

Thorpe JM, Thorpe CT, Gellad WF, Good CB, Hanlon JT, Mor MK, Pleis JR, Schleiden LJ, Van Houtven CH.

Dual Health Care System Use and High-Risk Prescribing in Patients With Dementia: A National Cohort Study. Ann Intern Med. 2017 Feb 7;166(3):157-163.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Thorpe CT, Fowler NR, Harrigan K, Zhao X, Kang Y, Hanlon JT, Gellad WF, Schleiden LJ, Thorpe JM. Racial and Ethnic Differences in Initiation and Discontinuation of Antidementia Drugs by Medicare Beneficiaries. J Am Geriatr Soc. 2016 Sep;64(9):1806-14.

Marcum ZA, Perera S, Thorpe JM, Switzer GE, Castle NG, Strotmeyer ES, Simonsick EM, Ayonayon HN, Phillips CL, Rubin S, Zucker-Levin AR, Bauer DC, Shorr RI, Kang Y, Gray SL, Hanlon JT; Health ABC Study. Antidepressant Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study. Ann Pharmacother. 2016 Jul;50(7):525-33.

Mary P. Kotlarczyk, PhD

Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL. Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer. Front Oncol. 2019 Jul 9;9:525.

Brach JS, Almeida GJ, Perera S, Hergenroeder A, Kotlarczyk M, Gibbs BB. The Role of the Environment on Sedentary Behavior in Community-Dwelling Older Adults. J Hous Elderly. 2019;33(1):31-40.

Hergenroeder AL, Barone Gibbs B, Kotlarczyk MP, Kowalsky RJ, Perera S, Brach JS. Accuracy of Objective Physical Activity Monitors in Measuring Steps in Older Adults. Gerontol Geriatr Med. 2018 Jun 17;4:2333721418781126.

Maria S, Samsonraj RM, Munmun F, Glas J, Silvestros M, Kotlarczyk MP, Rylands R, Dudakovic A, van Wijnen AJ, Enderby LT, Lassila H, Dodda B, Davis VL, Balk J, Burow M, Bunnell BA, Witt-Enderby PA. Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis. J Pineal Res. 2018 Apr;64(3).

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Billaud M, Phillippi JA, Kotlarczyk MP, Hill JC, Ellis BW, St Croix CM, Cantu-Medéllin N, Kelley EE, Gleason TG. Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve. J Thorac Cardiovasc Surg. 2017 Nov;154(5):1756-1762.

Phillippi JA, Hill JC, Billaud M, Green BR, Kotlarczyk MP, Gleason TG. Bicuspid Aortic Valve Morphotype Correlates With Regional Antioxidant Gene Expression Profiles in the Proximal Ascending Aorta. Ann Thorac Surg. 2017 Jul;104(1):79-87.

41

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Opioid and Benzodiazepine Prescriptions Among Veterans Dually Enrolled in Medicare Part D and the Department of Veterans Affairs: A Cross-sectional Study. Ann Intern Med. 2018 Nov 6;169(9):593-601.

Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. J Am Med Dir Assoc. 2018 Sep;19(9):765-769.e3.

Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW, Ensrud K, Cauley JA; Study of Osteoporotic Fractures (SOF) Research Group. Anxiety symptoms and risk of dementia and mild cognitive impairment in the oldest old women. Aging Ment Health. 2018 Apr;22(4):474-482.

Gellad WF, Thorpe JM, Zhao X, Thorpe CT, Sileanu FE, Cashy JP, Hale JA, Mor MK, Radomski TR, Hausmann LRM, Donohue JM, Gordon AJ, Suda KJ, Stroupe KT, Hanlon JT, Cunningham FE, Good CB, Fine MJ. Impact of Dual Use of Department of Veterans Affairs and Medicare Part D Drug Benefits on Potentially Unsafe Opioid Use. Am J Public Health. 2018 Feb;108(2):248-255.

Gray SL, Hart LA, Perera S, Semla TP, Schmader KE, Hanlon JT. Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc. 2018 Feb;66(2):282-288.

Sagawa N, Marcum ZA, Boudreau RM, Hanlon JT, Albert SM, O'Hare C, Satterfield S, Schwartz AV, Vinik AI, Cauley JA, Harris TB, Newman AB, Strotmeyer ES; Health Aging Body Composition Study. Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study. Eur J Ageing. 2018 Jan 19;15(3):321-330.

Niznik J, Zhao X, Jiang T, Hanlon JT, Aspinall SL, Thorpe J, Thorpe C. Anticholinergic Prescribing in Medicare Part D Beneficiaries Residing in Nursing Homes: Results from a Retrospective Cross-Sectional Analysis of Medicare Data. Drugs Aging. 2017 Dec;34(12):925-939.

Jasuja GK, Bhasin S, Rose AJ, Reisman JI, Hanlon JT, Miller DR, Morreale AP, Pogach LM, Cunningham FE, Park A, Wiener RS, Gifford AL, Berlowitz DR. Provider and Site-Level Determinants of Testosterone Prescribing in the Veterans Healthcare System. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3226-3233.

Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Anxiety symptoms and risk of cognitive decline in older community-dwelling men. Int Psychogeriatr. 2017 Jul;29(7):1137-1145.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Jasuja GK, Bhasin S, Reisman JI, Hanlon JT, Miller DR, Morreale AP, Pogach LM, Cunningham FE, Park A, Berlowitz DR, Rose AJ. Who Gets Testosterone? Patient Characteristics Associated with Testosterone Prescribing in the Veteran Affairs System: a Cross-Sectional Study. J Gen Intern Med. 2017 Mar;32(3):304-311.

Thorpe JM, Thorpe CT, Gellad WF, Good CB, Hanlon JT, Mor MK, Pleis JR, Schleiden LJ, Van Houtven CH.

Dual Health Care System Use and High-Risk Prescribing in Patients With Dementia: A National Cohort Study. Ann Intern Med. 2017 Feb 7;166(3):157-163.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Thorpe CT, Fowler NR, Harrigan K, Zhao X, Kang Y, Hanlon JT, Gellad WF, Schleiden LJ, Thorpe JM. Racial and Ethnic Differences in Initiation and Discontinuation of Antidementia Drugs by Medicare Beneficiaries. J Am Geriatr Soc. 2016 Sep;64(9):1806-14.

Marcum ZA, Perera S, Thorpe JM, Switzer GE, Castle NG, Strotmeyer ES, Simonsick EM, Ayonayon HN, Phillips CL, Rubin S, Zucker-Levin AR, Bauer DC, Shorr RI, Kang Y, Gray SL, Hanlon JT; Health ABC Study. Antidepressant Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study. Ann Pharmacother. 2016 Jul;50(7):525-33.

Mary P. Kotlarczyk, PhD

Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL. Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer. Front Oncol. 2019 Jul 9;9:525.

Brach JS, Almeida GJ, Perera S, Hergenroeder A, Kotlarczyk M, Gibbs BB. The Role of the Environment on Sedentary Behavior in Community-Dwelling Older Adults. J Hous Elderly. 2019;33(1):31-40.

Hergenroeder AL, Barone Gibbs B, Kotlarczyk MP, Kowalsky RJ, Perera S, Brach JS. Accuracy of Objective Physical Activity Monitors in Measuring Steps in Older Adults. Gerontol Geriatr Med. 2018 Jun 17;4:2333721418781126.

Maria S, Samsonraj RM, Munmun F, Glas J, Silvestros M, Kotlarczyk MP, Rylands R, Dudakovic A, van Wijnen AJ, Enderby LT, Lassila H, Dodda B, Davis VL, Balk J, Burow M, Bunnell BA, Witt-Enderby PA. Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis. J Pineal Res. 2018 Apr;64(3).

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Billaud M, Phillippi JA, Kotlarczyk MP, Hill JC, Ellis BW, St Croix CM, Cantu-Medéllin N, Kelley EE, Gleason TG. Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve. J Thorac Cardiovasc Surg. 2017 Nov;154(5):1756-1762.

Phillippi JA, Hill JC, Billaud M, Green BR, Kotlarczyk MP, Gleason TG. Bicuspid Aortic Valve Morphotype Correlates With Regional Antioxidant Gene Expression Profiles in the Proximal Ascending Aorta. Ann Thorac Surg. 2017 Jul;104(1):79-87.

42

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Kotlarczyk MP, Billaud M, Green BR, Hill JC, Shiva S, Kelley EE, Phillippi JA, Gleason TG. Regional Disruptions in Endothelial Nitric Oxide Pathway Associated With Bicuspid Aortic Valve. Ann Thorac Surg. 2016 Oct;102(4):1274-81.

David A. Nace, MD, MPHNiznik JD, Zhao X, He M, Aspinall SL, Hanlon JT, Nace D, Thorpe JM, Thorpe CT. Factors Associated With Deprescribing Acetylcholinesterase Inhibitors in Older Nursing Home Residents With Severe Dementia. J Am Geriatr Soc. 2019 Sep;67(9):1871-1879.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Neelesh K. Nadkarni, MD, PhDRosso AL, Metti AL, Faulkner K, Redfern M, Yaffe K, Launer L, Elizabeth Shaaban C, Nadkarni NK, Rosano C. Complex Walking Tasks and Risk for Cognitive Decline in High Functioning Older Adults. J Alzheimers Dis. 2019;71(s1):S65-S73.

Perera S, Nadkarni NK, Wert D, VanSwearingen J, Brach JS. Intraclass Correlation Coefficients for Planning Cluster Randomized Trials in Community-Dwelling Older Adults. J Aging Health. 2018 Dec 6:898264318816216.

Wanigatunga AA, Manini TM, Cook DR, Katula J, Fielding RA, Kramer AF, Verghese J, Rapp SR, Sink KM, King AC, Buford TW, Anton S, Nadkarni N, Jennings JM, Reid K, Espeland MA, Gill TM, Pahor M, Nocera JR. Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-

Limited Older Adults. Front Aging Neurosci. 2018 Nov 15;10:341.

Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M; LIFE Study Group. Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun. 2017 Dec 21;9:77-80.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Nadkarni NK, Ricci E. Effectiveness of a Timing and Coordination Group Exercise Program to Improve Mobility in Community-Dwelling Older Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Oct 1;177(10):1437-1444.

Nadkarni NK, Lopez OL, Perera S, Studenski SA, Snitz BE, Erickson KI, Mathis CA, Nebes RD, Redfern M, Klunk WE. Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):431-437.

Nadkarni NK, Perera S, Snitz BE, Mathis CA, Price J, Williamson JD, DeKosky ST, Klunk WE, Lopez OL. Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. JAMA Neurol. 2017 Jan 1;74(1):82-90.

Nadkarni NK, Boudreau RM, Studenski SA, Lopez OL, Liu G, Kritchevsky S, Yaffe K, Newman AB, Rosano C. Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults. Neurology. 2016 Nov 8;87(19):1993-1999.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Wert D, Nadkarni NK, Ricci E. Stakeholder involvement in the design of a patient-centered comparative effectiveness trial of the "On the Move" group exercise program in community-dwelling older adults. Contemp Clin Trials. 2016 Sep;50:135-42.

Buford TW, Miller ME, Church TS, Gill TM, Henderson R, Hsu FC, McDermott MM, Nadkarni N, Pahor M, Stafford RS, Carter CS; LIFE Study Research Group. Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):974-81.

Anne B. Newman, MD, MPHBraganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S. Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight. 2019 May 23;5.

Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2019 May 14.

Garg PK, Biggs ML, Barzilay J, Djousse L, Hirsch C, Ix JH, Kizer JR, Tracy RP, Newman AB, Siscovick DS, Mukamal KJ. Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. Diab Vasc Dis Res. 2019 Sep;16(5):483-485.

Jung AY, Miljkovic I, Rubin S, Kritchevsky SB, Klepin HD, Newman AB, Cauley J, Ayonayon H, Harris TB, Murphy RA. Adherence to Cancer Prevention Guidelines among Older White and Black Adults in the Health ABC Study. Nutrients. 2019 May 3;11(5).

Marron MM, Harris TB, Boudreau RM, Clish CB, Moore SC, Murphy RA, Murthy VL, Sanders JL, Shah RV,

43

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Kotlarczyk MP, Billaud M, Green BR, Hill JC, Shiva S, Kelley EE, Phillippi JA, Gleason TG. Regional Disruptions in Endothelial Nitric Oxide Pathway Associated With Bicuspid Aortic Valve. Ann Thorac Surg. 2016 Oct;102(4):1274-81.

David A. Nace, MD, MPHNiznik JD, Zhao X, He M, Aspinall SL, Hanlon JT, Nace D, Thorpe JM, Thorpe CT. Factors Associated With Deprescribing Acetylcholinesterase Inhibitors in Older Nursing Home Residents With Severe Dementia. J Am Geriatr Soc. 2019 Sep;67(9):1871-1879.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Neelesh K. Nadkarni, MD, PhDRosso AL, Metti AL, Faulkner K, Redfern M, Yaffe K, Launer L, Elizabeth Shaaban C, Nadkarni NK, Rosano C. Complex Walking Tasks and Risk for Cognitive Decline in High Functioning Older Adults. J Alzheimers Dis. 2019;71(s1):S65-S73.

Perera S, Nadkarni NK, Wert D, VanSwearingen J, Brach JS. Intraclass Correlation Coefficients for Planning Cluster Randomized Trials in Community-Dwelling Older Adults. J Aging Health. 2018 Dec 6:898264318816216.

Wanigatunga AA, Manini TM, Cook DR, Katula J, Fielding RA, Kramer AF, Verghese J, Rapp SR, Sink KM, King AC, Buford TW, Anton S, Nadkarni N, Jennings JM, Reid K, Espeland MA, Gill TM, Pahor M, Nocera JR. Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-

Limited Older Adults. Front Aging Neurosci. 2018 Nov 15;10:341.

Datta R, Trentalange M, Van Ness PH, McGloin JM, Guralnik JM, Miller ME, Walkup MP, Nadkarni N, Pahor M, Gill TM, Quagliarello V, Juthani-Mehta M; LIFE Study Group. Serious adverse events of older adults in nursing home and community intervention trials. Contemp Clin Trials Commun. 2017 Dec 21;9:77-80.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Nadkarni NK, Ricci E. Effectiveness of a Timing and Coordination Group Exercise Program to Improve Mobility in Community-Dwelling Older Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Oct 1;177(10):1437-1444.

Nadkarni NK, Lopez OL, Perera S, Studenski SA, Snitz BE, Erickson KI, Mathis CA, Nebes RD, Redfern M, Klunk WE. Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):431-437.

Nadkarni NK, Perera S, Snitz BE, Mathis CA, Price J, Williamson JD, DeKosky ST, Klunk WE, Lopez OL. Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. JAMA Neurol. 2017 Jan 1;74(1):82-90.

Nadkarni NK, Boudreau RM, Studenski SA, Lopez OL, Liu G, Kritchevsky S, Yaffe K, Newman AB, Rosano C. Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults. Neurology. 2016 Nov 8;87(19):1993-1999.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Wert D, Nadkarni NK, Ricci E. Stakeholder involvement in the design of a patient-centered comparative effectiveness trial of the "On the Move" group exercise program in community-dwelling older adults. Contemp Clin Trials. 2016 Sep;50:135-42.

Buford TW, Miller ME, Church TS, Gill TM, Henderson R, Hsu FC, McDermott MM, Nadkarni N, Pahor M, Stafford RS, Carter CS; LIFE Study Research Group. Antihypertensive Use and the Effect of a Physical Activity Intervention in the Prevention of Major Mobility Disability Among Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):974-81.

Anne B. Newman, MD, MPHBraganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S. Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight. 2019 May 23;5.

Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2019 May 14.

Garg PK, Biggs ML, Barzilay J, Djousse L, Hirsch C, Ix JH, Kizer JR, Tracy RP, Newman AB, Siscovick DS, Mukamal KJ. Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. Diab Vasc Dis Res. 2019 Sep;16(5):483-485.

Jung AY, Miljkovic I, Rubin S, Kritchevsky SB, Klepin HD, Newman AB, Cauley J, Ayonayon H, Harris TB, Murphy RA. Adherence to Cancer Prevention Guidelines among Older White and Black Adults in the Health ABC Study. Nutrients. 2019 May 3;11(5).

Marron MM, Harris TB, Boudreau RM, Clish CB, Moore SC, Murphy RA, Murthy VL, Sanders JL, Shah RV,

44

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Tseng GC, Wendell SG, Zmuda JM, Newman AB. Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men. Metabolites. 2019 Apr 30;9(5).

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019 Aug;67(8):1559-1564.

Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Brown T, Kiel DP, Cummings SR, Shardel M, Guralnik J, Woodhouse LJ, Pahor M, Binder E, D'Agostino RB, Xue QL, Orwoll E, Landi F, Orwig D, Schaap L, Latham N NK, Hirani V, Kwok T, Pereira S, Rooks D, Kashiwa M,

Torres-Gonzalez M, Menetski JP, Correa-De-Araujo R, Bhasin S; Sarcopenia Definition and Outcomes Consortium Conference participants. Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci. 2019 Mar 14.

Verreijen AM, Engberink MF, Houston DK, Brouwer IA, Cawthon PM, Newman AB, Tylavsky FA, Harris TB, Weijs PJM, Visser M. Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2019 Mar 1;109(3):535-543.

Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2019 Feb 21.

Fanning J, Rejeski WJ, Chen SH, Nicklas BJ, Walkup MP, Axtell RS, Fielding RA, Glynn NW, King AC, Manini TM, McDermott MM, Newman AB, Pahor M, Tudor-Locke C, Miller ME; LIFE Study Investigators. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 Feb 19.

Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, Borecki IB, Broer L, Buchman AS, Byberg L, Campbell H, Campos-Obando N, Cauley JA, Cawthon PM, Chambers JC, Chen Z, Cho NH, Choi HJ, Chou WC, Cummings SR, de Groot LCPGM, De Jager PL, Demuth I, Diatchenko L, Econs MJ, Eiriksdottir G, Enneman AW, Eriksson J, Eriksson JG, Estrada K, Evans DS, Feitosa MF, Fu M, Gieger C, Grallert H, Gudnason V, Lenore LJ, Hayward C, Hofman A, Homuth G, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Johnson T, Biffar R, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koller DL, Kooner JS, Kraus WE, Kritchevsky S, Kutalik Z, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Lerch MM, Lewis JR, Lill C, Lind L, Lindgren C, Liu Y, Livshits G, Ljunggren Ö, Loos RJF, Lorentzon M, Luan J, Luben RN, Malkin I, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Nethander M, Newman AB, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Peacock M, Perola M, Peters A, Prince RL, Psaty BM, Räikkönen K, Ralston SH, Ripatti S, Rivadeneira F, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schipf S, Shin CS, Smith AV, Smith SB, Soranzo N, Spector TD, Stancáková A, Stefansson K, Steinhagen-Thiessen E, Stolk L, Streeten EA, Styrkarsdottir U, Swart KMA, Thompson P, Thomson CA, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Uitterlinden AG, van Duijn CM, van Schoor NM, Vandenput L, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, J Wareham N, Waterworth D, Weedon MN, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Zhou Y, Nielson CM, Harris TB, Demissie S, Kiel DP, Ohlsson C.

Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 Feb 1;109(2):276-287.

Duan-Porter W, Vo TN, Ullman K, Langsetmo L, Strotmeyer ES, Taylor BC, Santanasto AJ, Cawthon PM, Newman AB, Simonsick EM, Waters TM, Ensrud KE. Hospitalization-Associated Change in Gait Speed and Risk of Functional Limitations for Older Adults. J Gerontol A Biol Sci Med Sci. 2019 Feb 4.

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study. A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity. Metabolism. 2019 May;94:28-38.

McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; ASPREE Investigator Group. Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 22.

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16.

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Tseng GC, Wendell SG, Zmuda JM, Newman AB. Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men. Metabolites. 2019 Apr 30;9(5).

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019 Aug;67(8):1559-1564.

Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Brown T, Kiel DP, Cummings SR, Shardel M, Guralnik J, Woodhouse LJ, Pahor M, Binder E, D'Agostino RB, Xue QL, Orwoll E, Landi F, Orwig D, Schaap L, Latham N NK, Hirani V, Kwok T, Pereira S, Rooks D, Kashiwa M,

Torres-Gonzalez M, Menetski JP, Correa-De-Araujo R, Bhasin S; Sarcopenia Definition and Outcomes Consortium Conference participants. Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci. 2019 Mar 14.

Verreijen AM, Engberink MF, Houston DK, Brouwer IA, Cawthon PM, Newman AB, Tylavsky FA, Harris TB, Weijs PJM, Visser M. Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2019 Mar 1;109(3):535-543.

Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2019 Feb 21.

Fanning J, Rejeski WJ, Chen SH, Nicklas BJ, Walkup MP, Axtell RS, Fielding RA, Glynn NW, King AC, Manini TM, McDermott MM, Newman AB, Pahor M, Tudor-Locke C, Miller ME; LIFE Study Investigators. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 Feb 19.

Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, Borecki IB, Broer L, Buchman AS, Byberg L, Campbell H, Campos-Obando N, Cauley JA, Cawthon PM, Chambers JC, Chen Z, Cho NH, Choi HJ, Chou WC, Cummings SR, de Groot LCPGM, De Jager PL, Demuth I, Diatchenko L, Econs MJ, Eiriksdottir G, Enneman AW, Eriksson J, Eriksson JG, Estrada K, Evans DS, Feitosa MF, Fu M, Gieger C, Grallert H, Gudnason V, Lenore LJ, Hayward C, Hofman A, Homuth G, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Johnson T, Biffar R, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koller DL, Kooner JS, Kraus WE, Kritchevsky S, Kutalik Z, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Lerch MM, Lewis JR, Lill C, Lind L, Lindgren C, Liu Y, Livshits G, Ljunggren Ö, Loos RJF, Lorentzon M, Luan J, Luben RN, Malkin I, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Nethander M, Newman AB, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Peacock M, Perola M, Peters A, Prince RL, Psaty BM, Räikkönen K, Ralston SH, Ripatti S, Rivadeneira F, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schipf S, Shin CS, Smith AV, Smith SB, Soranzo N, Spector TD, Stancáková A, Stefansson K, Steinhagen-Thiessen E, Stolk L, Streeten EA, Styrkarsdottir U, Swart KMA, Thompson P, Thomson CA, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Uitterlinden AG, van Duijn CM, van Schoor NM, Vandenput L, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, J Wareham N, Waterworth D, Weedon MN, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Zhou Y, Nielson CM, Harris TB, Demissie S, Kiel DP, Ohlsson C.

Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 Feb 1;109(2):276-287.

Duan-Porter W, Vo TN, Ullman K, Langsetmo L, Strotmeyer ES, Taylor BC, Santanasto AJ, Cawthon PM, Newman AB, Simonsick EM, Waters TM, Ensrud KE. Hospitalization-Associated Change in Gait Speed and Risk of Functional Limitations for Older Adults. J Gerontol A Biol Sci Med Sci. 2019 Feb 4.

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study. A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity. Metabolism. 2019 May;94:28-38.

McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; ASPREE Investigator Group. Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 22.

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019 Jan 16.

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke

46

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 Jan 3;104(1):112-138.

Lunney JR, Albert SM, Boudreau R, Ives D, Newman AB, Harris T. Fluctuating Physical Function and Health: Their Role at the End of Life. J Palliat Med. 2019 Apr;22(4):424-426.

Pahor M, Anton SD, Beavers DP, Cauley JA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, Lovato LC, Lu J, Manini TM, McDermott MM, Miller ME, Newman AB, Radziszewska B, Stowe CL, Tracy RP, Walkup MP, Wu SS, Ambrosius WT; ENRGISE study investigators. Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2018 Dec 12.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141.

Venditti EM, Zgibor JC, Vander Bilt J, Kieffer LA, Boudreau RM, Burke LE, Glynn NW, Jakicic JM, Smith KJ, Semler LN, Rager JR, Albert SM, Newman AB. Mobility and Vitality Lifestyle Program (MOVE UP): A Community Health Worker Intervention for Older Adults With Obesity to Improve Weight, Health, and Physical Function. Innov Aging. 2018 Jun 18;2(2):igy012.

Odden MC, Koh WJH, Arnold AM, Rawlings AM, Psaty BM, Newman AB. Trajectories of Nonagenarian Health: Sex, Age, and Period Effects. Am J Epidemiol. 2019 Feb 1;188(2):382-388.

Buford TW, Manini TM, Kairalla JA, McDermott MM, Vaz Fragoso CA, Chen H, Fielding RA, King AC, Newman AB, Tranah GJ. Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc. 2018 Sep 18;7(18):e010009.

Liu Z, Hsu FC, Trombetti A, King AC, Liu CK, Manini TM, Fielding RA, Pahor M, Newman AB, Kritchevsky S, Gill TM; LIFE Study investigators. Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med. 2018 Oct 24;16(1):185.

Manini TM, Buford TW, Kairalla JA, McDermott MM, Vaz Fragoso CA, Fielding RA, Hsu FC, Johannsen N, Kritchevsky S, Harris TB, Newman AB, Cummings SR, King AC, Pahor M, Santanasto AJ, Tranah GJ. Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. Geroscience. 2018 Dec;40(5-6):497-511.

Lai HT, de Oliveira Otto MC, Lemaitre RN, McKnight B, Song X, King IB, Chaves PH, Odden MC, Newman AB, Siscovick DS, Mozaffarian D. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study. BMJ. 2018 Oct 17;363:k4067.

Sagawa N, Marcum ZA, Boudreau RM, Hanlon JT, Albert SM, O'Hare C, Satterfield S, Schwartz AV, Vinik AI, Cauley JA, Harris TB, Newman AB, Strotmeyer ES; Health Aging Body Composition Study. Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study. Eur J Ageing. 2018 Jan 19;15(3):321-330.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1472-1481.

Cui C, Sekikawa A, Kuller LH, Lopez OL, Newman AB, Kuipers AL, Mackey RH. Aortic Stiffness is Associated with Increased Risk of Incident Dementia in Older Adults. J Alzheimers Dis. 2018;66(1):297-306.

Callahan KE, Lovato L, Miller ME, Marsh AP, Fielding RA, Gill TM, Groessl EJ, Guralnik J, King AC, Kritchevsky SB, McDermott MM, Manini T, Newman AB, Rejeski WJ. Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2018 Oct;66(10):1927-1933.

Marron MM, Ives DG, Boudreau RM, Harris TB, Newman AB. Racial Differences in Cause-Specific Mortality Between Community-Dwelling Older Black and White Adults. J Am Geriatr Soc. 2018 Oct;66(10):1980-1986.

McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. N Engl J Med. 2018 Oct 18;379(16):1499-1508.

McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018 Oct 18;379(16):1519-1528.

47

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 Jan 3;104(1):112-138.

Lunney JR, Albert SM, Boudreau R, Ives D, Newman AB, Harris T. Fluctuating Physical Function and Health: Their Role at the End of Life. J Palliat Med. 2019 Apr;22(4):424-426.

Pahor M, Anton SD, Beavers DP, Cauley JA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, Lovato LC, Lu J, Manini TM, McDermott MM, Miller ME, Newman AB, Radziszewska B, Stowe CL, Tracy RP, Walkup MP, Wu SS, Ambrosius WT; ENRGISE study investigators. Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2018 Dec 12.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141.

Venditti EM, Zgibor JC, Vander Bilt J, Kieffer LA, Boudreau RM, Burke LE, Glynn NW, Jakicic JM, Smith KJ, Semler LN, Rager JR, Albert SM, Newman AB. Mobility and Vitality Lifestyle Program (MOVE UP): A Community Health Worker Intervention for Older Adults With Obesity to Improve Weight, Health, and Physical Function. Innov Aging. 2018 Jun 18;2(2):igy012.

Odden MC, Koh WJH, Arnold AM, Rawlings AM, Psaty BM, Newman AB. Trajectories of Nonagenarian Health: Sex, Age, and Period Effects. Am J Epidemiol. 2019 Feb 1;188(2):382-388.

Buford TW, Manini TM, Kairalla JA, McDermott MM, Vaz Fragoso CA, Chen H, Fielding RA, King AC, Newman AB, Tranah GJ. Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc. 2018 Sep 18;7(18):e010009.

Liu Z, Hsu FC, Trombetti A, King AC, Liu CK, Manini TM, Fielding RA, Pahor M, Newman AB, Kritchevsky S, Gill TM; LIFE Study investigators. Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BMC Med. 2018 Oct 24;16(1):185.

Manini TM, Buford TW, Kairalla JA, McDermott MM, Vaz Fragoso CA, Fielding RA, Hsu FC, Johannsen N, Kritchevsky S, Harris TB, Newman AB, Cummings SR, King AC, Pahor M, Santanasto AJ, Tranah GJ. Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. Geroscience. 2018 Dec;40(5-6):497-511.

Lai HT, de Oliveira Otto MC, Lemaitre RN, McKnight B, Song X, King IB, Chaves PH, Odden MC, Newman AB, Siscovick DS, Mozaffarian D. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study. BMJ. 2018 Oct 17;363:k4067.

Sagawa N, Marcum ZA, Boudreau RM, Hanlon JT, Albert SM, O'Hare C, Satterfield S, Schwartz AV, Vinik AI, Cauley JA, Harris TB, Newman AB, Strotmeyer ES; Health Aging Body Composition Study. Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study. Eur J Ageing. 2018 Jan 19;15(3):321-330.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1472-1481.

Cui C, Sekikawa A, Kuller LH, Lopez OL, Newman AB, Kuipers AL, Mackey RH. Aortic Stiffness is Associated with Increased Risk of Incident Dementia in Older Adults. J Alzheimers Dis. 2018;66(1):297-306.

Callahan KE, Lovato L, Miller ME, Marsh AP, Fielding RA, Gill TM, Groessl EJ, Guralnik J, King AC, Kritchevsky SB, McDermott MM, Manini T, Newman AB, Rejeski WJ. Self-Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc. 2018 Oct;66(10):1927-1933.

Marron MM, Ives DG, Boudreau RM, Harris TB, Newman AB. Racial Differences in Cause-Specific Mortality Between Community-Dwelling Older Black and White Adults. J Am Geriatr Soc. 2018 Oct;66(10):1980-1986.

McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. N Engl J Med.2018 Oct 18;379(16):1499-1508.

McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018 Oct 18;379(16):1519-1528.

48

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Cauley JA, Manini TM, Lovato L, Talton J, Anton SD, Domanchuk K, Kennedy K, Stowe CL, Walkup M, Fielding RA, Kritchevsky SB, McDermott MM, Newman AB, Ambrosius WT, Pahor M; ENRGISE Investigators. The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results. J Gerontol A Biol Sci Med Sci. 2018 Sep 8.

Tranah GJ, Katzman SM, Lauterjung K, Yaffe K, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality. Sci Rep. 2018 Aug 8;8(1):11887.

Demb J, Wei EK, Izano M, Kritchevsky S, Swede H, Newman AB, Shlipak M, Akinyemiju T, Gregorich S, Braithwaite D. Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study. J Geriatr Oncol. 2019 Mar;10(2):265-271.

Nicholson CJ, Singh K, Saphirstein RJ, Gao YZ, Li Q, Chiu JG, Leavis P, Verwoert GC, Mitchell GF; AortaGen Consortium, Porter T, Morgan KG. Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. J Am Heart Assoc. 2018 Jul 18;7(15).

Tranah GJ, Maglione JE, Yaffe K, Katzman SM, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR; Health, Aging and Body Composition Study. Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly. Int J Geriatr Psychiatry. 2018 Oct;33(10):1319-1326.

Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs DR Jr, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Navas Acien A, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S, Barr RG. Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2018 Nov 1;187(11):2265-2278.

Albert SM, King J, Jones JR, Danielson ME, Park Y, Newman AB. Using the Infrastructure of State Aging Services to Promote Prevention Behavior. Prev Chronic Dis. 2018 Jul 5;15:E90.

Christensen MA, Dixit S, Dewland TA, Whitman IR, Nah G, Vittinghoff E, Mukamal KJ, Redline S, Robbins JA, Newman AB, Patel SR, Magnani JW, Psaty BM, Olgin JE, Pletcher MJ, Heckbert SR, Marcus GM. Sleep characteristics that predict atrial fibrillation. Heart Rhythm. 2018 Sep;15(9):1289-1295.

Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SD. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis. Ageing Res Rev. 2018 Sep;46:42-59.

Jammy GR, Boudreau RM, Singh T, Sharma PK, Ensrud K, Zmuda JM, Reddy PS, Newman AB, Cauley JA. Volumetric bone mineral density (vBMD), bone structure, and structural geometry among rural South Indian, US Caucasian, and Afro-Caribbean older men. Arch Osteoporos. 2018 May 22;13(1):60.

Moorthi RN, Doshi S, Fried LF, Moe SM, Sarnak MJ, Satterfield S, Schwartz AV, Shlipak M, Lange-Maia BS, Harris TB, Newman AB, Strotmeyer ES. Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study. Nephrol Dial Transplant. 2019 Apr 1;34(4):625-632.

O'Connell MDL, Marron MM, Boudreau RM, Canney M, Sanders JL, Kenny RA, Kritchevsky SB, Harris TB, Newman AB. Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging and Body

Composition Study. J Gerontol A Biol Sci Med Sci. 2018 May 4.

Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Sep;33(9):1612-1621.

Wu C, Geldhof GJ, Xue QL, Kim DH, Newman AB, Odden MC. Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts. Am J Epidemiol. 2018 Aug 1;187(8):1752-1762.

Wu C, Newman AB, Dong BR, Odden MC. Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study. J Am Geriatr Soc. 2018 Jul;66(7):1303-1310.

Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB. Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):114-120.

Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle A, Fried L, Sarnak MJ, Gutierrez OM. Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline. Am J Nephrol. 2018;47(4):242-250.

Hengeveld LM, Wijnhoven HAH, Olthof MR, Brouwer IA, Harris TB, Kritchevsky SB, Newman AB, Visser M; Health ABC Study. Prospective associations of poor diet quality with long-term incidence of protein-energy malnutrition in community-dwelling older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2018 Feb 1;107(2):155-164.

Hammond CA, Blades NJ, Chaudhry SI, Dodson JA, Longstreth WT Jr, Heckbert SR, Psaty BM, Arnold AM, Dublin S, Sitlani CM, Gardin JM, Thielke SM, Nanna MG, Gottesman RF, Newman AB, Thacker EL. Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circ Heart Fail. 2018 Mar;11(3):e004476.

Henderson RM, Miller ME, Fielding RA, Gill TM, Glynn NW, Guralnik JM, King A, Newman AB, Manini TM, Marsh AP, Pahor M, McDermott MM, Rejeski J, Tudor-Locke C, Kritchevsky SB; LIFE Study Investigators. Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):688-694.

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A; CHARGE Neurology Working Group, Chauhan G, Christensen K, Cocca M; COGENT-Kidney Consortium, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H; GIANT Consortium, Gigante B, Graff M, Gu CC, Gu D, Gupta

49

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Cauley JA, Manini TM, Lovato L, Talton J, Anton SD, Domanchuk K, Kennedy K, Stowe CL, Walkup M, Fielding RA, Kritchevsky SB, McDermott MM, Newman AB, Ambrosius WT, Pahor M; ENRGISE Investigators. The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results. J Gerontol A Biol Sci Med Sci. 2018 Sep 8.

Tranah GJ, Katzman SM, Lauterjung K, Yaffe K, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality. Sci Rep. 2018 Aug 8;8(1):11887.

Demb J, Wei EK, Izano M, Kritchevsky S, Swede H, Newman AB, Shlipak M, Akinyemiju T, Gregorich S, Braithwaite D. Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study. J Geriatr Oncol. 2019 Mar;10(2):265-271.

Nicholson CJ, Singh K, Saphirstein RJ, Gao YZ, Li Q, Chiu JG, Leavis P, Verwoert GC, Mitchell GF; AortaGen Consortium, Porter T, Morgan KG. Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. J Am Heart Assoc. 2018 Jul 18;7(15).

Tranah GJ, Maglione JE, Yaffe K, Katzman SM, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR; Health, Aging and Body Composition Study. Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly. Int J Geriatr Psychiatry. 2018 Oct;33(10):1319-1326.

Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs DR Jr, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Navas Acien A, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S, Barr RG. Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2018 Nov 1;187(11):2265-2278.

Albert SM, King J, Jones JR, Danielson ME, Park Y, Newman AB. Using the Infrastructure of State Aging Services to Promote Prevention Behavior. Prev Chronic Dis. 2018 Jul 5;15:E90.

Christensen MA, Dixit S, Dewland TA, Whitman IR, Nah G, Vittinghoff E, Mukamal KJ, Redline S, Robbins JA, Newman AB, Patel SR, Magnani JW, Psaty BM, Olgin JE, Pletcher MJ, Heckbert SR, Marcus GM. Sleep characteristics that predict atrial fibrillation. Heart Rhythm. 2018 Sep;15(9):1289-1295.

Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SD. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis. Ageing Res Rev. 2018 Sep;46:42-59.

Jammy GR, Boudreau RM, Singh T, Sharma PK, Ensrud K, Zmuda JM, Reddy PS, Newman AB, Cauley JA. Volumetric bone mineral density (vBMD), bone structure, and structural geometry among rural South Indian, US Caucasian, and Afro-Caribbean older men. Arch Osteoporos. 2018 May 22;13(1):60.

Moorthi RN, Doshi S, Fried LF, Moe SM, Sarnak MJ, Satterfield S, Schwartz AV, Shlipak M, Lange-Maia BS, Harris TB, Newman AB, Strotmeyer ES. Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study. Nephrol Dial Transplant. 2019 Apr 1;34(4):625-632.

O'Connell MDL, Marron MM, Boudreau RM, Canney M, Sanders JL, Kenny RA, Kritchevsky SB, Harris TB, Newman AB. Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging and Body

Composition Study. J Gerontol A Biol Sci Med Sci. 2018 May 4.

Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, Nagaraj N, Hoffman AR, Lane NE, Stefanick ML, Barrett-Connor E, Dam T, Cawthon PM, Orwoll ES, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018 Sep;33(9):1612-1621.

Wu C, Geldhof GJ, Xue QL, Kim DH, Newman AB, Odden MC. Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts. Am J Epidemiol. 2018 Aug 1;187(8):1752-1762.

Wu C, Newman AB, Dong BR, Odden MC. Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study. J Am Geriatr Soc. 2018 Jul;66(7):1303-1310.

Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB. Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):114-120.

Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle A, Fried L, Sarnak MJ, Gutierrez OM. Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline. Am J Nephrol. 2018;47(4):242-250.

Hengeveld LM, Wijnhoven HAH, Olthof MR, Brouwer IA, Harris TB, Kritchevsky SB, Newman AB, Visser M; Health ABC Study. Prospective associations of poor diet quality with long-term incidence of protein-energy malnutrition in community-dwelling older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2018 Feb 1;107(2):155-164.

Hammond CA, Blades NJ, Chaudhry SI, Dodson JA, Longstreth WT Jr, Heckbert SR, Psaty BM, Arnold AM, Dublin S, Sitlani CM, Gardin JM, Thielke SM, Nanna MG, Gottesman RF, Newman AB, Thacker EL. Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circ Heart Fail. 2018 Mar;11(3):e004476.

Henderson RM, Miller ME, Fielding RA, Gill TM, Glynn NW, Guralnik JM, King A, Newman AB, Manini TM, Marsh AP, Pahor M, McDermott MM, Rejeski J, Tudor-Locke C, Kritchevsky SB; LIFE Study Investigators. Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):688-694.

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A; CHARGE Neurology Working Group, Chauhan G, Christensen K, Cocca M; COGENT-Kidney Consortium, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H; GIANT Consortium, Gigante B, Graff M, Gu CC, Gu D, Gupta

50

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y; Lifelines Cohort Study, Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH Jr, Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400.

Baker JF, Newman AB, Kanaya A, Leonard MB, Zemel B, Miljkovic I, Long J, Weber D, Harris TB. The Adiponectin Paradox in the Elderly: Associations With Body Composition, Physical Functioning, and Mortality. J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):247-253.

Lunney JR, Albert SM, Boudreau R, Ives D, Satterfield S, Newman AB, Harris T; Health Aging and Body Composition Study. Mobility Trajectories at the End of Life: Comparing Clinical Condition and Latent Class Approaches. J Am Geriatr Soc. 2018 Mar;66(3):503-508.

Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, Fenech M, Koh WP. Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer. 2018 Jun 1;142(11):2234-2243.

Trombetti A, Hars M, Hsu FC, Reid KF, Church TS, Gill TM, King AC, Liu CK, Manini TM, McDermott MM, Newman AB, Rejeski WJ, Guralnik JM, Pahor M, Fielding RA; LIFE Study Investigators. Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med. 2018 Mar 6;168(5):309-316.

Yeri A, Murphy RA, Marron MM, Clish C, Harris TB, Lewis GD, Newman AB, Murthy VL, Shah RV. Metabolite Profiles of Healthy Aging Index Are Associated With Cardiovascular Disease in African Americans: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):68-72.

Lunney JR, Albert SM, Boudreau R, Ives D, Satterfield S, Newman AB, Harris T; Health ABC study. Three Year Functional Trajectories Among Old Age Survivors and Decedents: Dying Eliminates a Racial Disparity. J Gen Intern Med. 2018 Feb;33(2):177-181.

Cochrane SK, Chen SH, Fitzgerald JD, Dodson JA, Fielding RA, King AC, McDermott MM, Manini TM, Marsh

AP, Newman AB, Pahor M, Tudor-Locke C, Ambrosius WT, Buford TW; LIFE Study Research Group. Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. J Am Heart Assoc. 2017 Dec 2;6(12).

Murphy RA, Moore S, Playdon M, Kritchevsky S, Newman AB, Satterfield S, Ayonayon H, Clish C, Gerszten R, Harris TB. Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):73-80.

Chen W, Newman AB, Fried LF, Rifkin DE, Shlipak MG, Sarnak MJ, Katz R, Madero M, Raphael KL, Bushinsky DA, Ix JH. Relationship of acid-base status with arterial stiffness in community-living elders: the Health ABC Study. Nephrol Dial Transplant. 2018 Sep 1;33(9):1572-1579.

Jacob ME, Marron MM, Boudreau RM, Odden MC, Arnold AM, Newman AB. Age, Race, and Gender Factors in Incident Disability. J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):194-197.

Best JR, Liu-Ambrose T, Metti AL, Rosso AL, Satterfield S, Studenski S, Newman AB, Rosano C; Health, Aging and Body Composition Study. Longitudinal Associations Between Walking Speed and Amount of Self-reported Time Spent Walking Over a 9-Year Period in Older Women and Men. J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1265-1271.

Sanders JL, Guo W, O'Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR. Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):953-959.

Rejeski WJ, Walkup MP, Fielding RA, King AC, Manini T, Marsh AP, McDermott M, Miller EY, Newman AB, Tudor-Locke C, Axtell RS, Miller ME; LIFE Study Investigators. Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):660-667.

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, Liu X, Ang WQ, Zhang W, Feitosa MF, Venturini C, van der Most PJ, Rosengren A, Wood AR, Beaumont RN, Jones SE, Ruth KS, Yaghootkar H, Tyrrell J, Havulinna AS, Boers H, Mägi R, Kriebel J, Müller-Nurasyid M, Perola M, Nieminen M, Lokki ML, Kähönen M, Viikari JS, Geller F, Lahti J, Palotie A, Koponen P, Lundqvist A, Rissanen H, Bottinger EP, Afaq S, Wojczynski MK, Lenzini P, Nolte IM, Sparsø T, Schupf N, Christensen K, Perls TT, Newman AB, Werge T, Snieder H, Spector TD, Chambers JC, Koskinen S, Melbye M, Raitakari OT, Lehtimäki T, Tobin MD, Wain LV, Sinisalo J, Peters A, Meitinger T, Martin NG, Wray NR, Montgomery GW, Medland SE, Swertz MA, Vartiainen E, Borodulin K, Männistö S, Murray A, Bochud M, Jacquemont S, Rivadeneira F, Hansen TF, Oldehinkel AJ, Mangino M, Province MA, Deloukas P, Kooner JS, Freathy RM, Pennell C, Feenstra B, Strachan DP, Lettre G, Hirschhorn J, Cusi D, Heid IM, Hayward C, Männik K, Beckmann JS, Loos RJF, Nyholt DR, Metspalu A, Eriksson JG, Weedon MN, Salomaa V, Franke L, Reymond A, Frayling TM, Kutalik Z. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun. 2017 Sep 29;8(1):744.

Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR; Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) and Action for Health Movement and Memory Ancillary Study Research Groups. Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory

51

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y; Lifelines Cohort Study, Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH Jr, Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400.

Baker JF, Newman AB, Kanaya A, Leonard MB, Zemel B, Miljkovic I, Long J, Weber D, Harris TB. The Adiponectin Paradox in the Elderly: Associations With Body Composition, Physical Functioning, and Mortality. J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):247-253.

Lunney JR, Albert SM, Boudreau R, Ives D, Satterfield S, Newman AB, Harris T; Health Aging and Body Composition Study. Mobility Trajectories at the End of Life: Comparing Clinical Condition and Latent Class Approaches. J Am Geriatr Soc. 2018 Mar;66(3):503-508.

Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, Fenech M, Koh WP. Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer. 2018 Jun 1;142(11):2234-2243.

Trombetti A, Hars M, Hsu FC, Reid KF, Church TS, Gill TM, King AC, Liu CK, Manini TM, McDermott MM, Newman AB, Rejeski WJ, Guralnik JM, Pahor M, Fielding RA; LIFE Study Investigators. Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med. 2018 Mar 6;168(5):309-316.

Yeri A, Murphy RA, Marron MM, Clish C, Harris TB, Lewis GD, Newman AB, Murthy VL, Shah RV. Metabolite Profiles of Healthy Aging Index Are Associated With Cardiovascular Disease in African Americans: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):68-72.

Lunney JR, Albert SM, Boudreau R, Ives D, Satterfield S, Newman AB, Harris T; Health ABC study. Three Year Functional Trajectories Among Old Age Survivors and Decedents: Dying Eliminates a Racial Disparity. J Gen Intern Med. 2018 Feb;33(2):177-181.

Cochrane SK, Chen SH, Fitzgerald JD, Dodson JA, Fielding RA, King AC, McDermott MM, Manini TM, Marsh

AP, Newman AB, Pahor M, Tudor-Locke C, Ambrosius WT, Buford TW; LIFE Study Research Group. Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. J Am Heart Assoc. 2017 Dec 2;6(12).

Murphy RA, Moore S, Playdon M, Kritchevsky S, Newman AB, Satterfield S, Ayonayon H, Clish C, Gerszten R, Harris TB. Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):73-80.

Chen W, Newman AB, Fried LF, Rifkin DE, Shlipak MG, Sarnak MJ, Katz R, Madero M, Raphael KL, Bushinsky DA, Ix JH. Relationship of acid-base status with arterial stiffness in community-living elders: the Health ABC Study. Nephrol Dial Transplant. 2018 Sep 1;33(9):1572-1579.

Jacob ME, Marron MM, Boudreau RM, Odden MC, Arnold AM, Newman AB. Age, Race, and Gender Factors in Incident Disability. J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):194-197.

Best JR, Liu-Ambrose T, Metti AL, Rosso AL, Satterfield S, Studenski S, Newman AB, Rosano C; Health, Aging and Body Composition Study. Longitudinal Associations Between Walking Speed and Amount of Self-reported Time Spent Walking Over a 9-Year Period in Older Women and Men. J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1265-1271.

Sanders JL, Guo W, O'Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR. Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):953-959.

Rejeski WJ, Walkup MP, Fielding RA, King AC, Manini T, Marsh AP, McDermott M, Miller EY, Newman AB, Tudor-Locke C, Axtell RS, Miller ME; LIFE Study Investigators. Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):660-667.

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, Liu X, Ang WQ, Zhang W, Feitosa MF, Venturini C, van der Most PJ, Rosengren A, Wood AR, Beaumont RN, Jones SE, Ruth KS, Yaghootkar H, Tyrrell J, Havulinna AS, Boers H, Mägi R, Kriebel J, Müller-Nurasyid M, Perola M, Nieminen M, Lokki ML, Kähönen M, Viikari JS, Geller F, Lahti J, Palotie A, Koponen P, Lundqvist A, Rissanen H, Bottinger EP, Afaq S, Wojczynski MK, Lenzini P, Nolte IM, Sparsø T, Schupf N, Christensen K, Perls TT, Newman AB, Werge T, Snieder H, Spector TD, Chambers JC, Koskinen S, Melbye M, Raitakari OT, Lehtimäki T, Tobin MD, Wain LV, Sinisalo J, Peters A, Meitinger T, Martin NG, Wray NR, Montgomery GW, Medland SE, Swertz MA, Vartiainen E, Borodulin K, Männistö S, Murray A, Bochud M, Jacquemont S, Rivadeneira F, Hansen TF, Oldehinkel AJ, Mangino M, Province MA, Deloukas P, Kooner JS, Freathy RM, Pennell C, Feenstra B, Strachan DP, Lettre G, Hirschhorn J, Cusi D, Heid IM, Hayward C, Männik K, Beckmann JS, Loos RJF, Nyholt DR, Metspalu A, Eriksson JG, Weedon MN, Salomaa V, Franke L, Reymond A, Frayling TM, Kutalik Z. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun. 2017 Sep 29;8(1):744.

Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR; Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) and Action for Health Movement and Memory Ancillary Study Research Groups. Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory

52

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):484-491.

Forman DE, Santanasto AJ, Boudreau R, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AB. Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population. Circ Heart Fail. 2017 Sep;10(9).

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. J Hypertens. 2018 Jan;36(1):43-53.

Sparto PJ, Newman AB, Simonsick EM, Caserotti P, Strotmeyer ES, Kritchevsky SB, Yaffe K, Rosano C; Health ABC Study. Contributions to lateral balance control in ambulatory older adults. Aging Clin Exp Res. 2018 Jun;30(6):633-641.

Shaaban CE, Aizenstein HJ, Jorgensen DR, MacCloud RL, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C; LIFE Study Group. In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T. AJNR Am J Neuroradiol. 2017 Oct;38(10):1923-1928.

Yano Y, O'Donnell CJ, Kuller L, Kavousi M, Erbel R, Ning H, D'Agostino R, Newman AB, Nasir K, Hofman A, Lehmann N, Dhana K, Blankstein R, Hoffmann U, Möhlenkamp S, Massaro JM, Mahabadi AA, Lima JAC, Ikram MA, Jöckel KH, Franco OH, Liu K, Lloyd-Jones D, Greenland P. Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies. JAMA Cardiol. 2017 Sep 1;2(9):986-994.

van der Meij BS, Wijnhoven HAH, Lee JS, Houston DK, Hue T, Harris TB, Kritchevsky SB, Newman AB, Visser M. Poor Appetite and Dietary Intake in Community-Dwelling Older Adults. J Am Geriatr Soc. 2017 Oct;65(10):2190-2197.

Kuller LH, Lopez OL, Gottdiener JS, Kitzman DW, Becker JT, Chang Y, Newman AB. Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly. J Am Heart Assoc. 2017 Jul 22;6(7).

Manini TM, Anton SD, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu C, McDermott MM, Miller ME, Tracy RP, Walston JD, Radziszewska B, Lu J, Stowe C, Wu S, Newman AB, Ambrosius WT, Pahor M; ENRGISE Pilot study investigators. ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design. J Am Geriatr Soc. 2017 Sep;65(9):1961-1968.

Sharma PK, Bunker CH, Singh T, Ganguly E, Reddy PS, Newman AB, Cauley JA. Burden and Correlates of Falls among Rural Elders of South India: Mobility and Independent Living in Elders Study. Curr Gerontol Geriatr Res. 2017;2017:1290936.

Shechter A, Foster GD, Lang W, Reboussin DM, St-Onge MP, Zammit G, Newman AB, Millman RP, Wadden TA, Jakicic JM, Strotmeyer ES, Wing RR, Pi-Sunyer FX, Kuna ST; Sleep Ahead Research Group of the Look Ahead Research Group. Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes. J Sleep Res. 2017 Dec;26(6):747-755.

Winovich DT, Longstreth WT Jr, Arnold AM, Varadhan R, Zeki Al Hazzouri A, Cushman M, Newman AB, Odden MC. Factors Associated With Ischemic Stroke Survival and Recovery in Older Adults. Stroke. 2017 Jul;

48(7):1818-1826.

Cruz-Almeida Y, Rosso A, Marcum Z, Harris T, Newman AB, Nevitt M, Satterfield S, Yaffe K, Rosano C; Health ABC Study. Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms. J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1270-1276.

Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM; LIFE Study Investigators. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. J Gerontol B Psychol Sci Soc Sci. 2018 Oct 10;73(8):1501-1513.

Lange-Maia BS, Newman AB, Jakicic JM, Cauley JA, Boudreau RM, Schwartz AV, Simonsick EM, Satterfield S, Vinik AI, Zivkovic S, Harris TB, Strotmeyer ES. Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study. Exp Gerontol. 2017 Oct 1;96:38-45.

Jensen MK, Jensen RA, Mukamal KJ, Guo X, Yao J, Sun Q, Cornelis M, Liu Y, Chen MH, Kizer JR, Djoussé L, Siscovick DS, Psaty BM, Zmuda JM, Rotter JI, Garcia M, Harris T, Chen I, Goodarzi MO, Nalls MA, Keller M, Arnold AM, Newman AB, Hoogeveen RC, Rexrode KM, Rimm EB, Hu FB, Ramachandran VS, Katz R, Pankow JS, Ix JH. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet. 2017 Jun 1;26(11):2156-2163.

Gill TM, Beavers DP, Guralnik JM, Pahor M, Fielding RA, Hauser M, Manini TM, Marsh AP, McDermott MM, Newman AB, Allore HG, Miller ME; LIFE Study Investigators. The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial. BMC Med. 2017 Mar 28;15(1):65.

Smitson CC, Scherzer R, Shlipak MG, Psaty BM, Newman AB, Sarnak MJ, Odden MC, Peralta CA. Association of Blood Pressure Trajectory With Mortality, Incident Cardiovascular Disease, and Heart Failure in the Cardiovascular Health Study. Am J Hypertens. 2017 Jun 1;30(6):587-593.

Smagula SF, Beach S, Rosso AL, Newman AB, Schulz R. Brain Structural Markers and Caregiving Characteristics as Interacting Correlates of Caregiving Strain. Am J Geriatr Psychiatry. 2017 Jun;25(6): 582-591.

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Kaplan CM, Waters T, Ayonayon HN, Rubin SM, Newman AB, Harris T. Are Preferences for Aggressive Medical Treatment Associated with Healthcare Utilization in the Very Old? J Palliat Med. 2017 Mar 23.

McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; ASPREE Investigator Group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1586-1593.

Wu C, Smit E, Sanders JL, Newman AB, Odden MC. A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1437-1444.

Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, Newman AB, Kammerer CM. Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):484-491.

Forman DE, Santanasto AJ, Boudreau R, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AB. Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population. Circ Heart Fail. 2017 Sep;10(9).

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. J Hypertens. 2018 Jan;36(1):43-53.

Sparto PJ, Newman AB, Simonsick EM, Caserotti P, Strotmeyer ES, Kritchevsky SB, Yaffe K, Rosano C; Health ABC Study. Contributions to lateral balance control in ambulatory older adults. Aging Clin Exp Res. 2018 Jun;30(6):633-641.

Shaaban CE, Aizenstein HJ, Jorgensen DR, MacCloud RL, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C; LIFE Study Group. In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T. AJNR Am J Neuroradiol. 2017 Oct;38(10):1923-1928.

Yano Y, O'Donnell CJ, Kuller L, Kavousi M, Erbel R, Ning H, D'Agostino R, Newman AB, Nasir K, Hofman A, Lehmann N, Dhana K, Blankstein R, Hoffmann U, Möhlenkamp S, Massaro JM, Mahabadi AA, Lima JAC, Ikram MA, Jöckel KH, Franco OH, Liu K, Lloyd-Jones D, Greenland P. Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies. JAMA Cardiol. 2017 Sep 1;2(9):986-994.

van der Meij BS, Wijnhoven HAH, Lee JS, Houston DK, Hue T, Harris TB, Kritchevsky SB, Newman AB, Visser M. Poor Appetite and Dietary Intake in Community-Dwelling Older Adults. J Am Geriatr Soc. 2017 Oct;65(10):2190-2197.

Kuller LH, Lopez OL, Gottdiener JS, Kitzman DW, Becker JT, Chang Y, Newman AB. Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly. J Am Heart Assoc. 2017 Jul 22;6(7).

Manini TM, Anton SD, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu C, McDermott MM, Miller ME, Tracy RP, Walston JD, Radziszewska B, Lu J, Stowe C, Wu S, Newman AB, Ambrosius WT, Pahor M; ENRGISE Pilot study investigators. ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design. J Am Geriatr Soc. 2017 Sep;65(9):1961-1968.

Sharma PK, Bunker CH, Singh T, Ganguly E, Reddy PS, Newman AB, Cauley JA. Burden and Correlates of Falls among Rural Elders of South India: Mobility and Independent Living in Elders Study. Curr Gerontol Geriatr Res. 2017;2017:1290936.

Shechter A, Foster GD, Lang W, Reboussin DM, St-Onge MP, Zammit G, Newman AB, Millman RP, Wadden TA, Jakicic JM, Strotmeyer ES, Wing RR, Pi-Sunyer FX, Kuna ST; Sleep Ahead Research Group of the Look Ahead Research Group. Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes. J Sleep Res. 2017 Dec;26(6):747-755.

Winovich DT, Longstreth WT Jr, Arnold AM, Varadhan R, Zeki Al Hazzouri A, Cushman M, Newman AB, Odden MC. Factors Associated With Ischemic Stroke Survival and Recovery in Older Adults. Stroke. 2017 Jul;

48(7):1818-1826.

Cruz-Almeida Y, Rosso A, Marcum Z, Harris T, Newman AB, Nevitt M, Satterfield S, Yaffe K, Rosano C; Health ABC Study. Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms. J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1270-1276.

Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM; LIFE Study Investigators. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. J Gerontol B Psychol Sci Soc Sci. 2018 Oct 10;73(8):1501-1513.

Lange-Maia BS, Newman AB, Jakicic JM, Cauley JA, Boudreau RM, Schwartz AV, Simonsick EM, Satterfield S, Vinik AI, Zivkovic S, Harris TB, Strotmeyer ES. Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study. Exp Gerontol. 2017 Oct 1;96:38-45.

Jensen MK, Jensen RA, Mukamal KJ, Guo X, Yao J, Sun Q, Cornelis M, Liu Y, Chen MH, Kizer JR, Djoussé L, Siscovick DS, Psaty BM, Zmuda JM, Rotter JI, Garcia M, Harris T, Chen I, Goodarzi MO, Nalls MA, Keller M, Arnold AM, Newman AB, Hoogeveen RC, Rexrode KM, Rimm EB, Hu FB, Ramachandran VS, Katz R, Pankow JS, Ix JH. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet. 2017 Jun 1;26(11):2156-2163.

Gill TM, Beavers DP, Guralnik JM, Pahor M, Fielding RA, Hauser M, Manini TM, Marsh AP, McDermott MM, Newman AB, Allore HG, Miller ME; LIFE Study Investigators. The effect of intervening hospitalizations on the benefit of structured physical activity in promoting independent mobility among community-living older persons: secondary analysis of a randomized controlled trial. BMC Med. 2017 Mar 28;15(1):65.

Smitson CC, Scherzer R, Shlipak MG, Psaty BM, Newman AB, Sarnak MJ, Odden MC, Peralta CA. Association of Blood Pressure Trajectory With Mortality, Incident Cardiovascular Disease, and Heart Failure in the Cardiovascular Health Study. Am J Hypertens. 2017 Jun 1;30(6):587-593.

Smagula SF, Beach S, Rosso AL, Newman AB, Schulz R. Brain Structural Markers and Caregiving Characteristics as Interacting Correlates of Caregiving Strain. Am J Geriatr Psychiatry. 2017 Jun;25(6): 582-591.

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Kaplan CM, Waters T, Ayonayon HN, Rubin SM, Newman AB, Harris T. Are Preferences for Aggressive Medical Treatment Associated with Healthcare Utilization in the Very Old? J Palliat Med. 2017 Mar 23.

McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; ASPREE Investigator Group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1586-1593.

Wu C, Smit E, Sanders JL, Newman AB, Odden MC. A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1437-1444.

Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, Newman AB, Kammerer CM. Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Family Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411-1416.

Odden MC, Koh WJH, Arnold AM, Psaty BM, Newman AB. Health and Functional Status of Adults Aged 90 Years in the United States. JAMA Intern Med. 2017 May 1;177(5):732-734.

Houston DK, Tooze JA, Garcia K, Visser M, Rubin S, Harris TB, Newman AB, Kritchevsky SB; Health ABC Study. Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc. 2017 Aug;65(8):1705-1711.

Santanasto AJ, Glynn NW, Lovato LC, Blair SN, Fielding RA, Gill TM, Guralnik JM, Hsu FC, King AC, Strotmeyer ES, Manini TM, Marsh AP, McDermott MM, Goodpaster BH, Pahor M, Newman AB; LIFE Study Group. Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility. J Am Geriatr Soc. 2017 Jul;65(7):1427-1433.

Singh T, Sharma PK, Jammy GR, Cauley JA, Bunker CH, Reddy PS, Newman AB. Design of the Mobility and Independent Living in Elders Study: An older adult cohort in rural India. Geriatr Gerontol Int. 2017 Jan;17(1):31-40.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SL, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY). 2017 Jan 10;9(1):209-246.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017 Apr;16(2):329-338.

Ahiawodzi PD, Kerber RA, Taylor KC, Groves FD, O'Brien E, Ix JH, Kizer JR, Djoussé L, Tracy RP, Newman AB, Siscovick DS, Robbins J, Mukamal K. Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers. 2017 May - Jun;22(3-4):361-366.

Murphy RA, Moore SC, Playdon M, Meirelles O, Newman AB, Milijkovic I, Kritchevsky SB, Schwartz A, Goodpaster BH, Sampson J, Cawthon P, Simonsick EM, Gerszten RE, Clish CB, Harris TB; Health ABC Study. Metabolites Associated With Lean Mass and Adiposity in Older Black Men. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1352-1359.

Pandey A, Khan H, Newman AB, Lakatta EG, Forman DE, Butler J, Berry JD. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition). Hypertension. 2017 Feb;69(2):267-274.

Rosano C, Guralnik J, Pahor M, Glynn NW, Newman AB, Ibrahim TS, Erickson K, Cohen R, Shaaban CE, MacCloud RL, Aizenstein HJ. Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults. Am J Geriatr Psychiatry. 2017 Mar;25(3):209-217.

Aubertin-Leheudre M, Anton S, Beavers DP, Manini TM, Fielding R, Newman A, Church T, Kritchevsky SB, Conroy D, McDermott MM, Botoseneanu A, Hauser ME, Pahor M; LIFE Research Group. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc. 2017 Apr 1;18(4):312-319.

Roshanravan B, Patel KV, Fried LF, Robinson-Cohen C, de Boer IH, Harris T, Murphy RA, Satterfield S, Goodpaster BH, Shlipak M, Newman AB, Kestenbaum B; Health ABC study. Association of Muscle Endurance, Fatigability, and Strength With Functional Limitation and Mortality in the Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):284-291.

Zgibor JC, Ye L, Boudreau RM, Conroy MB, Vander Bilt J, Rodgers EA, Schlenk EA, Jacob ME, Brandenstein J, Albert SM, Newman AB. Community-Based Healthy Aging Interventions for Older Adults with Arthritis and Multimorbidity. J Community Health. 2017 Apr;42(2):390-399.

Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, Schminke U, Stitziel NO, Tada H, van Setten J, Smith AV, Vojinovic D, Yanek LR, Yao J, Yerges-Armstrong LM, Amin N, Baber U, Borecki IB, Carr JJ, Chen YI, Cupples LA, de Jong PA, de Koning H, de Vos BD, Demirkan A, Fuster V, Franco OH, Goodarzi MO, Harris TB, Heckbert SR, Heiss G, Hoffmann U, Hofman A, Išgum I, Jukema JW, Kähönen M, Kardia SL, Kral BG, Launer LJ, Massaro J, Mehran R, Mitchell BD, Mosley TH Jr, de Mutsert R, Newman AB, Nguyen KD, North KE, O'Connell JR, Oudkerk M, Pankow JS, Peloso GM, Post W, Province MA, Raffield LM, Raitakari OT, Reilly DF, Rivadeneira F, Rosendaal F, Sartori S, Taylor KD, Teumer A, Trompet S, Turner ST, Uitterlinden AG, Vaidya D, van der Lugt A, Völker U, Wardlaw JM, Wassel CL, Weiss S, Wojczynski MK, Becker DM, Becker LC, Boerwinkle E, Bowden DW, Deary IJ, Dehghan A, Felix SB, Gudnason V, Lehtimäki T, Mathias R, Mook- Kanamori DO, Psaty BM, Rader DJ, Rotter JI, Wilson JG, van Duijn CM, Völzke H, Kathiresan S, Peyser PA, O'Donnell CJ; CHARGE Consortium. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520.

Fung CH, Vitiello MV, Alessi CA, Kuchel GA; AGS/NIA Sleep Conference Planning Committee and Faculty. Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning. J Am Geriatr Soc. 2016 Dec;64(12):e238-e247.

Georgiopoulou VV, Kalogeropoulos AP, Chowdhury R, Binongo JN, Bibbins-Domingo K, Rodondi N, Simonsick EM, Harris T, Newman AB, Kritchevsky SB, Butler J; Health ABC Study. Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults: The Health ABC Study. Am J Prev Med. 2017 Feb;52(2):144-153.

Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA; Health ABC Study. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):e1.

Chaker L, Baumgartner C, den Elzen WP, Collet TH, Ikram MA, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies ML, Iervasi G, Medici M, Stott DJ, Dullaart RP, Ford I, Bremner A, Newman AB, Wanner C, Sgarbi JA, Dörr M, Longstreth WT Jr, Psaty BM, Ferrucci L, Maciel RM, Westendorp RG, Jukema JW, Ceresini G, Imaizumi M, Hofman A, Bakker SJ, Franklyn JA, Khaw KT, Bauer DC, Walsh JP, Razvi S, Gussekloo J, Völzke H,

55

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Family Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411-1416.

Odden MC, Koh WJH, Arnold AM, Psaty BM, Newman AB. Health and Functional Status of Adults Aged 90 Years in the United States. JAMA Intern Med. 2017 May 1;177(5):732-734.

Houston DK, Tooze JA, Garcia K, Visser M, Rubin S, Harris TB, Newman AB, Kritchevsky SB; Health ABC Study. Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc. 2017 Aug;65(8):1705-1711.

Santanasto AJ, Glynn NW, Lovato LC, Blair SN, Fielding RA, Gill TM, Guralnik JM, Hsu FC, King AC, Strotmeyer ES, Manini TM, Marsh AP, McDermott MM, Goodpaster BH, Pahor M, Newman AB; LIFE Study Group. Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility. J Am Geriatr Soc. 2017 Jul;65(7):1427-1433.

Singh T, Sharma PK, Jammy GR, Cauley JA, Bunker CH, Reddy PS, Newman AB. Design of the Mobility and Independent Living in Elders Study: An older adult cohort in rural India. Geriatr Gerontol Int. 2017 Jan;17(1):31-40.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SL, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY). 2017 Jan 10;9(1):209-246.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017 Apr;16(2):329-338.

Ahiawodzi PD, Kerber RA, Taylor KC, Groves FD, O'Brien E, Ix JH, Kizer JR, Djoussé L, Tracy RP, Newman AB, Siscovick DS, Robbins J, Mukamal K. Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers. 2017 May - Jun;22(3-4):361-366.

Murphy RA, Moore SC, Playdon M, Meirelles O, Newman AB, Milijkovic I, Kritchevsky SB, Schwartz A, Goodpaster BH, Sampson J, Cawthon P, Simonsick EM, Gerszten RE, Clish CB, Harris TB; Health ABC Study. Metabolites Associated With Lean Mass and Adiposity in Older Black Men. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1352-1359.

Pandey A, Khan H, Newman AB, Lakatta EG, Forman DE, Butler J, Berry JD. Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition). Hypertension. 2017 Feb;69(2):267-274.

Rosano C, Guralnik J, Pahor M, Glynn NW, Newman AB, Ibrahim TS, Erickson K, Cohen R, Shaaban CE, MacCloud RL, Aizenstein HJ. Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults. Am J Geriatr Psychiatry. 2017 Mar;25(3):209-217.

Aubertin-Leheudre M, Anton S, Beavers DP, Manini TM, Fielding R, Newman A, Church T, Kritchevsky SB, Conroy D, McDermott MM, Botoseneanu A, Hauser ME, Pahor M; LIFE Research Group. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc. 2017 Apr 1;18(4):312-319.

Roshanravan B, Patel KV, Fried LF, Robinson-Cohen C, de Boer IH, Harris T, Murphy RA, Satterfield S, Goodpaster BH, Shlipak M, Newman AB, Kestenbaum B; Health ABC study. Association of Muscle Endurance, Fatigability, and Strength With Functional Limitation and Mortality in the Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):284-291.

Zgibor JC, Ye L, Boudreau RM, Conroy MB, Vander Bilt J, Rodgers EA, Schlenk EA, Jacob ME, Brandenstein J, Albert SM, Newman AB. Community-Based Healthy Aging Interventions for Older Adults with Arthritis and Multimorbidity. J Community Health. 2017 Apr;42(2):390-399.

Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, Schminke U, Stitziel NO, Tada H, van Setten J, Smith AV, Vojinovic D, Yanek LR, Yao J, Yerges-Armstrong LM, Amin N, Baber U, Borecki IB, Carr JJ, Chen YI, Cupples LA, de Jong PA, de Koning H, de Vos BD, Demirkan A, Fuster V, Franco OH, Goodarzi MO, Harris TB, Heckbert SR, Heiss G, Hoffmann U, Hofman A, Išgum I, Jukema JW, Kähönen M, Kardia SL, Kral BG, Launer LJ, Massaro J, Mehran R, Mitchell BD, Mosley TH Jr, de Mutsert R, Newman AB, Nguyen KD, North KE, O'Connell JR, Oudkerk M, Pankow JS, Peloso GM, Post W, Province MA, Raffield LM, Raitakari OT, Reilly DF, Rivadeneira F, Rosendaal F, Sartori S, Taylor KD, Teumer A, Trompet S, Turner ST, Uitterlinden AG, Vaidya D, van der Lugt A, Völker U, Wardlaw JM, Wassel CL, Weiss S, Wojczynski MK, Becker DM, Becker LC, Boerwinkle E, Bowden DW, Deary IJ, Dehghan A, Felix SB, Gudnason V, Lehtimäki T, Mathias R, Mook-Kanamori DO, Psaty BM, Rader DJ, Rotter JI, Wilson JG, van Duijn CM, Völzke H, Kathiresan S, Peyser PA, O'Donnell CJ; CHARGE Consortium. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520.

Fung CH, Vitiello MV, Alessi CA, Kuchel GA; AGS/NIA Sleep Conference Planning Committee and Faculty. Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning. J Am Geriatr Soc. 2016 Dec;64(12):e238-e247.

Georgiopoulou VV, Kalogeropoulos AP, Chowdhury R, Binongo JN, Bibbins-Domingo K, Rodondi N, Simonsick EM, Harris T, Newman AB, Kritchevsky SB, Butler J; Health ABC Study. Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults: The Health ABC Study. Am J Prev Med. 2017 Feb;52(2):144-153.

Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA; Health ABC Study. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):e1.

Chaker L, Baumgartner C, den Elzen WP, Collet TH, Ikram MA, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies ML, Iervasi G, Medici M, Stott DJ, Dullaart RP, Ford I, Bremner A, Newman AB, Wanner C, Sgarbi JA, Dörr M, Longstreth WT Jr, Psaty BM, Ferrucci L, Maciel RM, Westendorp RG, Jukema JW, Ceresini G, Imaizumi M, Hofman A, Bakker SJ, Franklyn JA, Khaw KT, Bauer DC, Walsh JP, Razvi S, Gussekloo J, Völzke H,

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Franco OH, Cappola AR, Rodondi N, Peeters RP; Thyroid Studies Collaboration. Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2016 Nov;101(11):4270-4282.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc. 2016 Nov;64(11):e189-e194.

Jacob ME, Yee LM, Diehr PH, Arnold AM, Thielke SM, Chaves PH, Gobbo LD, Hirsch C, Siscovick D, Newman AB. Can a Healthy Lifestyle Compress the Disabled Period in Older Adults? J Am Geriatr Soc. 2016 Oct;64(10):1952-1961.

Miner B, Tinetti ME, Van Ness PH, Han L, Leo-Summers L, Newman AB, Lee PJ, Vaz Fragoso CA. Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition. J Am Geriatr Soc. 2016 Oct;64(10):2042-2050.

Nadkarni NK, Boudreau RM, Studenski SA, Lopez OL, Liu G, Kritchevsky S, Yaffe K, Newman AB, Rosano C. Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults. Neurology. 2016 Nov 8;87(19):1993-1999.

Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728.

Gill TM, Guralnik JM, Pahor M, Church T, Fielding RA, King AC, Marsh AP, Newman AB, Pellegrini CA, Chen SH, Allore HG, Miller ME; LIFE Study Investigators. Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial. Ann Intern Med. 2016 Dec 20;165(12):833-840.

Wu C, Shlipak MG, Stawski RS, Peralta CA, Psaty BM, Harris TB, Satterfield S, Shiroma EJ, Newman AB, Odden MC; Health ABC Study. Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study. Am J Hypertens. 2017 Feb;30(2):151-158.

deFilippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M, Church T, Espeland M, Krithevsky SB, Stafford R, Seliger SL; LIFE Study Group. Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention. Am Heart J. 2016 Sep;179:151-6.

Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW; LIFE Study Investigators. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Arch Phys Med Rehabil. 2017 Jan;98(1):11-24.e3.

Santanasto AJ, Goodpaster BH, Kritchevsky SB, Miljkovic I, Satterfield S, Schwartz AV, Cummings SR, Boudreau RM, Harris TB, Newman AB. Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):513-519.

Chalhoub D, Orwoll ES, Cawthon PM, Ensrud KE, Boudreau R, Greenspan S, Newman AB, Zmuda J, Bauer D,

Cummings S, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Areal and volumetric bone mineral density and risk of multiple types of fracture in older men. Bone. 2016 Nov;92:100-106.

Grosicki GJ, Standley RA, Murach KA, Raue U, Minchev K, Coen PM, Newman AB, Cummings S, Harris T, Kritchevsky S, Goodpaster BH, Trappe S; Health ABC Study. Improved single muscle fiber quality in the oldest-old. J Appl Physiol (1985). 2016 Oct 1;121(4):878-884.

Rosano C, Perera S, Inzitari M, Newman AB, Longstreth WT, Studenski S. Digit Symbol Substitution test and future clinical and subclinical disorders of cognition, mobility and mood in older adults. Age Ageing. 2016 Sep;45(5):688-95.

Newman AB, Dodson JA, Church TS, Buford TW, Fielding RA, Kritchevsky S, Beavers D, Pahor M, Stafford RS, Szady AD, Ambrosius WT, McDermott MM; LIFE Study Group. Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized Trial. JAMA Cardiol. 2016 Aug 1;1(5):568-74.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L; CHARGE Longevity Working Group, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJ; Body Composition Genetics Consortium, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A, Uh HW, van Duijn CM, van Heemst D, Vandenput L, Vasan RS, Völker U, Willems SM, Ohlsson C, Wallaschofski H, Kaplan RC. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016 Oct;15(5):811-24.

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher

T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 Oct;15(5):792-800.

Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB; Long Life Family Study Research Group. Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology. J Am Geriatr Soc. 2016 Aug;64(8):1679-83.

Newman AB, Sanders JL, Kizer JR, Boudreau RM, Odden MC, Zeki Al Hazzouri A, Arnold AM. Trajectories of function and biomarkers with age: the CHS All Stars Study. Int J Epidemiol. 2016 Aug;45(4):1135-1145.

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Ayonayon HN, Rubin SM, Newman AB, Harris

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Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Franco OH, Cappola AR, Rodondi N, Peeters RP; Thyroid Studies Collaboration. Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2016 Nov;101(11):4270-4282.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc. 2016 Nov;64(11):e189-e194.

Jacob ME, Yee LM, Diehr PH, Arnold AM, Thielke SM, Chaves PH, Gobbo LD, Hirsch C, Siscovick D, Newman AB. Can a Healthy Lifestyle Compress the Disabled Period in Older Adults? J Am Geriatr Soc. 2016 Oct;64(10):1952-1961.

Miner B, Tinetti ME, Van Ness PH, Han L, Leo-Summers L, Newman AB, Lee PJ, Vaz Fragoso CA. Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition. J Am Geriatr Soc. 2016 Oct;64(10):2042-2050.

Nadkarni NK, Boudreau RM, Studenski SA, Lopez OL, Liu G, Kritchevsky S, Yaffe K, Newman AB, Rosano C. Slow gait, white matter characteristics, and prior 10-year interleukin-6 levels in older adults. Neurology. 2016 Nov 8;87(19):1993-1999.

Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728.

Gill TM, Guralnik JM, Pahor M, Church T, Fielding RA, King AC, Marsh AP, Newman AB, Pellegrini CA, Chen SH, Allore HG, Miller ME; LIFE Study Investigators. Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial. Ann Intern Med. 2016 Dec 20;165(12):833-840.

Wu C, Shlipak MG, Stawski RS, Peralta CA, Psaty BM, Harris TB, Satterfield S, Shiroma EJ, Newman AB, Odden MC; Health ABC Study. Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study. Am J Hypertens. 2017 Feb;30(2):151-158.

deFilippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M, Church T, Espeland M, Krithevsky SB, Stafford R, Seliger SL; LIFE Study Group. Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention. Am Heart J. 2016 Sep;179:151-6.

Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW; LIFE Study Investigators. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Arch Phys Med Rehabil. 2017 Jan;98(1):11-24.e3.

Santanasto AJ, Goodpaster BH, Kritchevsky SB, Miljkovic I, Satterfield S, Schwartz AV, Cummings SR, Boudreau RM, Harris TB, Newman AB. Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):513-519.

Chalhoub D, Orwoll ES, Cawthon PM, Ensrud KE, Boudreau R, Greenspan S, Newman AB, Zmuda J, Bauer D,

Cummings S, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group. Areal and volumetric bone mineral density and risk of multiple types of fracture in older men. Bone. 2016 Nov;92:100-106.

Grosicki GJ, Standley RA, Murach KA, Raue U, Minchev K, Coen PM, Newman AB, Cummings S, Harris T, Kritchevsky S, Goodpaster BH, Trappe S; Health ABC Study. Improved single muscle fiber quality in the oldest-old. J Appl Physiol (1985). 2016 Oct 1;121(4):878-884.

Rosano C, Perera S, Inzitari M, Newman AB, Longstreth WT, Studenski S. Digit Symbol Substitution test and future clinical and subclinical disorders of cognition, mobility and mood in older adults. Age Ageing. 2016 Sep;45(5):688-95.

Newman AB, Dodson JA, Church TS, Buford TW, Fielding RA, Kritchevsky S, Beavers D, Pahor M, Stafford RS, Szady AD, Ambrosius WT, McDermott MM; LIFE Study Group. Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized Trial. JAMA Cardiol. 2016 Aug 1;1(5):568-74.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L; CHARGE Longevity Working Group, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJ; Body Composition Genetics Consortium, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A, Uh HW, van Duijn CM, van Heemst D, Vandenput L, Vasan RS, Völker U, Willems SM, Ohlsson C, Wallaschofski H, Kaplan RC. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016 Oct;15(5):811-24.

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher

T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 Oct;15(5):792-800.

Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB; Long Life Family Study Research Group. Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology. J Am Geriatr Soc. 2016 Aug;64(8):1679-83.

Newman AB, Sanders JL, Kizer JR, Boudreau RM, Odden MC, Zeki Al Hazzouri A, Arnold AM. Trajectories of function and biomarkers with age: the CHS All Stars Study. Int J Epidemiol. 2016 Aug;45(4):1135-1145.

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Ayonayon HN, Rubin SM, Newman AB, Harris

58

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

T; Health ABC Study. Symptom Burden and End-of-Life Treatment Preferences in the Very Old. J Pain Symptom Manage. 2016 Sep;52(3):404-11.

Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA; Health ABC Study. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1688-1694.

McCabe EL, Larson MG, Lunetta KL, Newman AB, Cheng S, Murabito JM. Association of an Index of Healthy Aging With Incident Cardiovascular Disease and Mortality in a Community-Based Sample of Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1695-1701.

Kim F, Biggs ML, Kizer JR, Brutsaert EF, de Filippi C, Newman AB, Kronmal RA, Tracy RP, Gottdiener JS, Djoussé L, de Boer IH, Psaty BM, Siscovick DS, Mukamal KJ. Brain natriuretic peptide and insulin resistance in older adults. Diabet Med. 2017 Feb;34(2):235-238.

Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB. The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol. 2016 Aug;81:1-7.

Barbour KE, Lui LY, McCulloch CE, Ensrud KE, Cawthon PM, Yaffe K, Barnes DE, Fredman L, Newman AB, Cummings SR, Cauley JA; Study of Osteoporotic Fractures. Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1609-1615.

Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA. The FoxO3 gene and cause-specific mortality. Aging Cell. 2016 Aug;15(4):617-24.

Best JR, Liu-Ambrose T, Boudreau RM, Ayonayon HN, Satterfield S, Simonsick EM, Studenski S, Yaffe K, Newman AB, Rosano C; Health, Aging and Body Composition Study. An Evaluation of the Longitudinal, Bidirectional Associations Between Gait Speed and Cognition in Older Women and Men. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1616-1623.

Henderson RM, Lovato L, Miller ME, Fielding RA, Church TS, Newman AB, Buford TW, Pahor M, McDermott MM, Stafford RS, Lee DS, Kritchevsky SB; LIFE Study Investigators. Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1519-1524.

Lange-Maia BS, Cauley JA, Newman AB, Boudreau RM, Jakicic JM, Glynn NW, Zivkovic S, Dam TL, Caserotti P, Cawthon PM, Orwoll ES, Strotmeyer ES; Osteoporotic Fractures in Men (MrOS) Study Group. Sensorimotor Peripheral Nerve Function and Physical Activity in Older Men. J Aging Phys Act. 2016 Oct;24(4):559-566.

Rosario BL, Rosso AL, Aizenstein HJ, Harris T, Newman AB, Satterfield S, Studenski SA, Yaffe K, Rosano C; Health ABC Study. Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):968-73.

Subashan Perera, PhDBrach JS, Almeida GJ, Perera S, Hergenroeder A, Kotlarczyk M, Gibbs BB. The Role of the Environment on Sedentary Behavior in Community-Dwelling Older Adults. J Hous Elderly. 2019;33(1):31-40.

Alqahtani BA, Sparto PJ, Whitney SL, Greenspan SL, Perera S, Brach JS. Psychometric Properties of Lower Extremity Strength Measurements Recorded in Community Settings in Independent Living Older Adults. Exp Aging Res. 2019 May-Jun;45(3):282-292.

Merrill Z, Perera S, Chambers A, Cham R. Age and body mass index associations with body segment parameters. J Biomech. 2019 May 9;88:38-47.

Hanlon JT, Perera S, Drinka PJ, Crnich CJ, Schweon SJ, Klein-Fedyshin M, Wessel CB, Saracco S, Anderson G, Mulligan M, Nace DA. The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. J Am Geriatr Soc. 2019 Mar;67(3):539-545.

Zhang Z, Perera S, Donohue C, Kurosu A, Mahoney AS, Coyle JL, Sejdić E. The Prediction of Risk of Penetration-Aspiration Via Hyoid Bone Displacement Features. Dysphagia. 2019 Mar 27.

Perera S, Nadkarni NK, Wert D, VanSwearingen J, Brach JS. Intraclass Correlation Coefficients for Planning Cluster Randomized Trials in Community-Dwelling Older Adults. J Aging Health. 2018 Dec 6:898264318816216.

Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. J Am Med Dir Assoc. 2018 Sep;19(9):765-769.e3.

Hergenroeder AL, Barone Gibbs B, Kotlarczyk MP, Kowalsky RJ, Perera S, Brach JS. Accuracy of Objective Physical Activity Monitors in Measuring Steps in Older Adults. Gerontol Geriatr Med. 2018 Jun 17;4:2333721418781126.

Almarwani M, Van Swearingen JM, Perera S, Sparto PJ, Brach JS. The Effect of Auditory Cueing on the Spatial and Temporal Gait Coordination in Healthy Adults. J Mot Behav. 2019;51(1):25-31.

Jacobs ZG, Elnicki DM, Perera S, Weiner DK. An E-learning Module on Chronic Low Back Pain in Older Adults: Effect on Medical Resident Attitudes, Confidence, Knowledge, and Clinical Skills. Pain Med. 2018 Jun 1;19(6):1112-1120.

Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018 May;15(5):615-621.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Jestrović I, Coyle JL, Perera S, Sejdić E. Influence of attention and bolus volume on brain organization during swallowing. Brain Struct Funct. 2018 Mar;223(2):955-964.

Wert DM, Perera S, Nutini JF, Ricci EM, Coffman L, Turnquist R, VanSwearingen J, Brach J. Motor Control-based Group Exercise: Can It be Delivered as Effectively by Lay Leaders? Transl J Am Coll Sports Med. 2018 Feb;3(3):19-27.

Gray SL, Hart LA, Perera S, Semla TP, Schmader KE, Hanlon JT. Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc. 2018 Feb;66(2):282-288.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term

59

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

T; Health ABC Study. Symptom Burden and End-of-Life Treatment Preferences in the Very Old. J Pain Symptom Manage. 2016 Sep;52(3):404-11.

Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA; Health ABC Study. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1688-1694.

McCabe EL, Larson MG, Lunetta KL, Newman AB, Cheng S, Murabito JM. Association of an Index of Healthy Aging With Incident Cardiovascular Disease and Mortality in a Community-Based Sample of Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1695-1701.

Kim F, Biggs ML, Kizer JR, Brutsaert EF, de Filippi C, Newman AB, Kronmal RA, Tracy RP, Gottdiener JS, Djoussé L, de Boer IH, Psaty BM, Siscovick DS, Mukamal KJ. Brain natriuretic peptide and insulin resistance in older adults. Diabet Med. 2017 Feb;34(2):235-238.

Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB. The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol. 2016 Aug;81:1-7.

Barbour KE, Lui LY, McCulloch CE, Ensrud KE, Cawthon PM, Yaffe K, Barnes DE, Fredman L, Newman AB, Cummings SR, Cauley JA; Study of Osteoporotic Fractures. Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1609-1615.

Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA. The FoxO3 gene and cause-specific mortality. Aging Cell. 2016 Aug;15(4):617-24.

Best JR, Liu-Ambrose T, Boudreau RM, Ayonayon HN, Satterfield S, Simonsick EM, Studenski S, Yaffe K, Newman AB, Rosano C; Health, Aging and Body Composition Study. An Evaluation of the Longitudinal, Bidirectional Associations Between Gait Speed and Cognition in Older Women and Men. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1616-1623.

Henderson RM, Lovato L, Miller ME, Fielding RA, Church TS, Newman AB, Buford TW, Pahor M, McDermott MM, Stafford RS, Lee DS, Kritchevsky SB; LIFE Study Investigators. Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1519-1524.

Lange-Maia BS, Cauley JA, Newman AB, Boudreau RM, Jakicic JM, Glynn NW, Zivkovic S, Dam TL, Caserotti P, Cawthon PM, Orwoll ES, Strotmeyer ES; Osteoporotic Fractures in Men (MrOS) Study Group. Sensorimotor Peripheral Nerve Function and Physical Activity in Older Men. J Aging Phys Act. 2016 Oct;24(4):559-566.

Rosario BL, Rosso AL, Aizenstein HJ, Harris T, Newman AB, Satterfield S, Studenski SA, Yaffe K, Rosano C; Health ABC Study. Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):968-73.

Subashan Perera, PhDBrach JS, Almeida GJ, Perera S, Hergenroeder A, Kotlarczyk M, Gibbs BB. The Role of the Environment on Sedentary Behavior in Community-Dwelling Older Adults. J Hous Elderly. 2019;33(1):31-40.

Alqahtani BA, Sparto PJ, Whitney SL, Greenspan SL, Perera S, Brach JS. Psychometric Properties of Lower Extremity Strength Measurements Recorded in Community Settings in Independent Living Older Adults. Exp Aging Res. 2019 May-Jun;45(3):282-292.

Merrill Z, Perera S, Chambers A, Cham R. Age and body mass index associations with body segment parameters. J Biomech. 2019 May 9;88:38-47.

Hanlon JT, Perera S, Drinka PJ, Crnich CJ, Schweon SJ, Klein-Fedyshin M, Wessel CB, Saracco S, Anderson G, Mulligan M, Nace DA. The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. J Am Geriatr Soc. 2019 Mar;67(3):539-545.

Zhang Z, Perera S, Donohue C, Kurosu A, Mahoney AS, Coyle JL, Sejdić E. The Prediction of Risk of Penetration-Aspiration Via Hyoid Bone Displacement Features. Dysphagia. 2019 Mar 27.

Perera S, Nadkarni NK, Wert D, VanSwearingen J, Brach JS. Intraclass Correlation Coefficients for Planning Cluster Randomized Trials in Community-Dwelling Older Adults. J Aging Health. 2018 Dec 6:898264318816216.

Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. J Am Med Dir Assoc. 2018 Sep;19(9):765-769.e3.

Hergenroeder AL, Barone Gibbs B, Kotlarczyk MP, Kowalsky RJ, Perera S, Brach JS. Accuracy of Objective Physical Activity Monitors in Measuring Steps in Older Adults. Gerontol Geriatr Med. 2018 Jun 17;4:2333721418781126.

Almarwani M, Van Swearingen JM, Perera S, Sparto PJ, Brach JS. The Effect of Auditory Cueing on the Spatial and Temporal Gait Coordination in Healthy Adults. J Mot Behav. 2019;51(1):25-31.

Jacobs ZG, Elnicki DM, Perera S, Weiner DK. An E-learning Module on Chronic Low Back Pain in Older Adults: Effect on Medical Resident Attitudes, Confidence, Knowledge, and Clinical Skills. Pain Med. 2018 Jun 1;19(6):1112-1120.

Bon J, Zhang Y, Leader JK, Fuhrman C, Perera S, Chandra D, Bertolet M, Diergaarde B, Greenspan SL, Sciurba FC. Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc. 2018 May;15(5):615-621.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Jestrović I, Coyle JL, Perera S, Sejdić E. Influence of attention and bolus volume on brain organization during swallowing. Brain Struct Funct. 2018 Mar;223(2):955-964.

Wert DM, Perera S, Nutini JF, Ricci EM, Coffman L, Turnquist R, VanSwearingen J, Brach J. Motor Control-based Group Exercise: Can It be Delivered as Effectively by Lay Leaders? Transl J Am Coll Sports Med. 2018 Feb;3(3):19-27.

Gray SL, Hart LA, Perera S, Semla TP, Schmader KE, Hanlon JT. Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc. 2018 Feb;66(2):282-288.

Kotlarczyk MP, Perera S, Nace DA, Resnick NM, Greenspan SL. Identifying Sarcopenia in Female Long-Term

60

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S. Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur. Osteoporos Int. 2018 Feb;29(2):501-506.

O'Connell C, Mahboobin A, Drexler S, Redfern MS, Perera S, Nau AC, Cham R. Effects of acute peripheral/central visual field loss on standing balance. Exp Brain Res. 2017 Nov;235(11):3261-3270.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Nadkarni NK, Ricci E. Effectiveness of a Timing and Coordination Group Exercise Program to Improve Mobility in Community-Dwelling Older Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Oct 1;177(10):1437-1444.

Alqahtani BA, Ferchak MA, Huppert TJ, Sejdic E, Perera S, Greenspan SL, Sparto PJ. Standing balance and strength measurements in older adults living in residential care communities. Aging Clin Exp Res. 2017 Oct;29(5):1021-1030.

Gatouillat A, Dumortier A, Perera S, Badr Y, Gehin C, Sejdić E. Analysis of the pen pressure and grip force signal during basic drawing tasks: The timing and speed changes impact drawing characteristics. Comput Biol Med. 2017 Aug 1;87:124-131.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Movahedi F, Kurosu A, Coyle JL, Perera S, Sejdić E. A comparison between swallowing sounds and vibrations in patients with dysphagia. Comput Methods Programs Biomed. 2017 Jun;144:179-187.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Tyagi S, Perera S, Brach JS. Balance and Mobility in Community-Dwelling Older Adults: Effect of Daytime Sleepiness. J Am Geriatr Soc. 2017 May;65(5):1019-1025.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Lewis RA, Christie WC, Day DG, Craven ER, Walters T, Bejanian M, Lee SS, Goodkin ML, Zhang J, Whitcup SM, Robinson MR; Bimatoprost SR Study Group. Bimatoprost Sustained-Release Implants for Glaucoma Therapy: 6-Month Results From a Phase I/II Clinical Trial. Am J Ophthalmol. 2017 Mar;175:137-147.

Kane-Gill SL, Niznik JD, Kellum JA, Culley CM, Boyce RD, Marcum ZA, He H, Perera S, Handler SM. Use of Telemedicine to Enhance Pharmacist Services in the Nursing Facility. Consult Pharm. 2017 Feb 1;32(2):93-98.

Zhang Z, VanSwearingen J, Brach JS, Perera S, Sejdić E. Most suitable mother wavelet for the analysis of fractal properties of stride interval time series via the average wavelet coefficient method. Comput Biol Med. 2017 Jan 1;80:175-184.

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing Home Data from Multiple Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252.

Lowry KA, Sebastian K, Perera S, Van Swearingen J, Smiley-Oyen AL. Age-Related Differences in Locomotor Strategies During Adaptive Walking. J Mot Behav. 2017 Jul-Aug;49(4):435-440.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Nadkarni NK, Lopez OL, Perera S, Studenski SA, Snitz BE, Erickson KI, Mathis CA, Nebes RD, Redfern M, Klunk WE. Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):431-437.

Nadkarni NK, Perera S, Snitz BE, Mathis CA, Price J, Williamson JD, DeKosky ST, Klunk WE, Lopez OL. Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. JAMA Neurol. 2017 Jan 1;74(1):82-90.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Jestrović I, Coyle JL, Perera S, Sejdić E. Functional connectivity patterns of normal human swallowing: difference among various viscosity swallows in normal and chin-tuck head positions. Brain Res. 2016 Dec 1;1652:158-169.

Almarwani M, VanSwearingen JM, Perera S, Sparto PJ, Brach JS. Challenging the motor control of walking: Gait variability during slower and faster pace walking conditions in younger and older adults. Arch Gerontol Geriatr. 2016 Sep-Oct;66:54-61.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Wert D, Nadkarni NK, Ricci E. Stakeholder involvement in the design of a patient-centered comparative effectiveness trial of the "On the Move" group exercise program in community-dwelling older adults. Contemp Clin Trials. 2016 Sep;50:135-42.

Rosano C, Perera S, Inzitari M, Newman AB, Longstreth WT, Studenski S. Digit Symbol Substitution test and future clinical and subclinical disorders of cognition, mobility and mood in older adults. Age Ageing. 2016 Sep;45(5):688-95.

Lo-Ciganic WH, Donohue JM, Jones BL, Perera S, Thorpe JM, Thorpe CT, Marcum ZA, Gellad WF. Trajectories of Diabetes Medication Adherence and Hospitalization Risk: A Retrospective Cohort Study in a Large State Medicaid Program. J Gen Intern Med. 2016 Sep;31(9):1052-60.

Prasad C, Greenspan SL, Vujevich KT, Brufsky A, Lembersky BC, van Londen GJ, Jankowitz RC, Puhalla SL, Rastogi P, Perera S. Risedronate may preserve bone microarchitecture in breast cancer survivors on aromatase inhibitors: A randomized, controlled clinical trial. Bone. 2016 Sep;90:123-6.

Marcum ZA, Perera S, Thorpe JM, Switzer GE, Castle NG, Strotmeyer ES, Simonsick EM, Ayonayon HN, 61

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Care Residents: A Comparison of Current Guidelines. J Am Geriatr Soc. 2018 Feb;66(2):316-320.

Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S. Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur. Osteoporos Int. 2018 Feb;29(2):501-506.

O'Connell C, Mahboobin A, Drexler S, Redfern MS, Perera S, Nau AC, Cham R. Effects of acute peripheral/central visual field loss on standing balance. Exp Brain Res. 2017 Nov;235(11):3261-3270.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Nadkarni NK, Ricci E. Effectiveness of a Timing and Coordination Group Exercise Program to Improve Mobility in Community-Dwelling Older Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Oct 1;177(10):1437-1444.

Alqahtani BA, Ferchak MA, Huppert TJ, Sejdic E, Perera S, Greenspan SL, Sparto PJ. Standing balance and strength measurements in older adults living in residential care communities. Aging Clin Exp Res. 2017 Oct;29(5):1021-1030.

Gatouillat A, Dumortier A, Perera S, Badr Y, Gehin C, Sejdić E. Analysis of the pen pressure and grip force signal during basic drawing tasks: The timing and speed changes impact drawing characteristics. Comput Biol Med. 2017 Aug 1;87:124-131.

Langmann GA, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017 Aug;65(8):1777-1783.

Perera S, Nace DA, Resnick NM, Greenspan SL. The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist. 2018 Jul 13;58(4):e197-e204.

Movahedi F, Kurosu A, Coyle JL, Perera S, Sejdić E. A comparison between swallowing sounds and vibrations in patients with dysphagia. Comput Methods Programs Biomed. 2017 Jun;144:179-187.

Hanlon JT, Zhao X, Naples JG, Aspinall SL, Perera S, Nace DA, Castle NG, Greenspan SL, Thorpe CT. Central Nervous System Medication Burden and Serious Falls in Older Nursing Home Residents. J Am Geriatr Soc. 2017 Jun;65(6):1183-1189.

Tyagi S, Perera S, Brach JS. Balance and Mobility in Community-Dwelling Older Adults: Effect of Daytime Sleepiness. J Am Geriatr Soc. 2017 May;65(5):1019-1025.

Kotlarczyk MP, Perera S, Ferchak MA, Nace DA, Resnick NM, Greenspan SL. Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation. Osteoporos Int. 2017 Apr;28(4):1347-1353.

Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, Shorr RI, Bauer DC, Marcum ZA; Health ABC Study. Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults. J Clin Pharm Ther. 2017 Apr;42(2):228-233.

Lewis RA, Christie WC, Day DG, Craven ER, Walters T, Bejanian M, Lee SS, Goodkin ML, Zhang J, Whitcup SM, Robinson MR; Bimatoprost SR Study Group. Bimatoprost Sustained-Release Implants for Glaucoma Therapy: 6-Month Results From a Phase I/II Clinical Trial. Am J Ophthalmol. 2017 Mar;175:137-147.

Kane-Gill SL, Niznik JD, Kellum JA, Culley CM, Boyce RD, Marcum ZA, He H, Perera S, Handler SM. Use of Telemedicine to Enhance Pharmacist Services in the Nursing Facility. Consult Pharm. 2017 Feb 1;32(2):93-98.

Zhang Z, VanSwearingen J, Brach JS, Perera S, Sejdić E. Most suitable mother wavelet for the analysis of fractal properties of stride interval time series via the average wavelet coefficient method. Comput Biol Med. 2017 Jan 1;80:175-184.

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing Home Data from Multiple Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252.

Lowry KA, Sebastian K, Perera S, Van Swearingen J, Smiley-Oyen AL. Age-Related Differences in Locomotor Strategies During Adaptive Walking. J Mot Behav. 2017 Jul-Aug;49(4):435-440.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Nadkarni NK, Lopez OL, Perera S, Studenski SA, Snitz BE, Erickson KI, Mathis CA, Nebes RD, Redfern M, Klunk WE. Cerebral Amyloid Deposition and Dual-Tasking in Cognitively Normal, Mobility Unimpaired Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):431-437.

Nadkarni NK, Perera S, Snitz BE, Mathis CA, Price J, Williamson JD, DeKosky ST, Klunk WE, Lopez OL. Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. JAMA Neurol. 2017 Jan 1;74(1):82-90.

Naples JG, Kotlarczyk MP, Perera S, Greenspan SL, Hanlon JT. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women. Am J Geriatr Psychiatry. 2016 Dec;24(12):1221-1227.

Jestrović I, Coyle JL, Perera S, Sejdić E. Functional connectivity patterns of normal human swallowing: difference among various viscosity swallows in normal and chin-tuck head positions. Brain Res. 2016 Dec 1;1652:158-169.

Almarwani M, VanSwearingen JM, Perera S, Sparto PJ, Brach JS. Challenging the motor control of walking: Gait variability during slower and faster pace walking conditions in younger and older adults. Arch Gerontol Geriatr. 2016 Sep-Oct;66:54-61.

Brach JS, Perera S, Gilmore S, VanSwearingen JM, Brodine D, Wert D, Nadkarni NK, Ricci E. Stakeholder involvement in the design of a patient-centered comparative effectiveness trial of the "On the Move" group exercise program in community-dwelling older adults. Contemp Clin Trials. 2016 Sep;50:135-42.

Rosano C, Perera S, Inzitari M, Newman AB, Longstreth WT, Studenski S. Digit Symbol Substitution test and future clinical and subclinical disorders of cognition, mobility and mood in older adults. Age Ageing. 2016 Sep;45(5):688-95.

Lo-Ciganic WH, Donohue JM, Jones BL, Perera S, Thorpe JM, Thorpe CT, Marcum ZA, Gellad WF. Trajectories of Diabetes Medication Adherence and Hospitalization Risk: A Retrospective Cohort Study in a Large State Medicaid Program. J Gen Intern Med. 2016 Sep;31(9):1052-60.

Prasad C, Greenspan SL, Vujevich KT, Brufsky A, Lembersky BC, van Londen GJ, Jankowitz RC, Puhalla SL, Rastogi P, Perera S. Risedronate may preserve bone microarchitecture in breast cancer survivors on aromatase inhibitors: A randomized, controlled clinical trial. Bone. 2016 Sep;90:123-6.

Marcum ZA, Perera S, Thorpe JM, Switzer GE, Castle NG, Strotmeyer ES, Simonsick EM, Ayonayon HN, 62

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Phillips CL, Rubin S, Zucker-Levin AR, Bauer DC, Shorr RI, Kang Y, Gray SL, Hanlon JT; Health ABC Study. Antidepressant Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study. Ann Pharmacother. 2016 Jul;50(7):525-33.

Eric G. Rodriguez, MD, MPHWright RM, Malec M, Shega J, Rodriguez E, Kulas J, Morrow L, Rodakowski J, Semla T, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part XI: Dementia. Pain Med. 2016 Nov;17(11):1993-2002.

Polsunas PJ, Sowa G, Fritz JM, Gentili A, Morone NE, Raja SN, Rodriguez E, Schmader K, Scholten JD, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part X: Sacroiliac Joint Syndrome. Pain Medicine. 2016 Sep;17(9):1638-47.

Karp JF, DiNapoli EA, Wetherell J, Bolon C, Rodriguez E, Shega J, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part IX: Anxiety. Pain Med. 2016 Aug;17(8):1423-35.

Michelle I. Rossi, MD, MPHChang W, Homer M, Rossi MI. Use of Clinical Video Telehealth as a Tool for Optimizing Medications for Rural Older Veterans with Dementia. Geriatrics. 2018 Jul 30;3(3):44.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Powers BB, Homer MC, Morone N, Edmonds N, Rossi MI. Creation of an Interprofessional Teledementia Clinic for Rural Veterans: Preliminary Data. J Am Geriatr Soc. 2017 May;65(5):1092-99.

Fred H. Rubin, MD

Rubin FH, Bellon J, Bilderback A, Urda K, Inouye SK. Effect of the Hospital Elder Life Program on Risk of 30-Day Readmission. J Am Geriatr Soc. 2018 Jan;66(1):145-149.

Leslie P. Scheunemann, MD, MPHScheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB. Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units. JAMA Intern Med. 2019 May 1;179(5):676-684.

Scheunemann LP, Khalil R, Rajagopal PS, Arnold RM. Development and Pilot Testing of a Simulation to Study How Physicians Facilitate Surrogate Decision Making Based on Critically Ill Patients' Values and Preferences. J Pain Symptom Manage. 2019 Feb;57(2):216-223.e8.

Cunningham TV, Scheunemann LP, Arnold RM, White D. How do clinicians prepare family members for the role of surrogate decision-maker? J Med Ethics. 2018 Jan;44(1):21-26.

Chiarchiaro J, Ernecoff NC, Scheunemann LP, Hough CL, Carson SS, Peterson MW, Anderson WG, Steingrub JS, Arnold RM, White DB. Physicians Rarely Elicit Critically Ill Patients’ Previously Expressed Treatment

Preferences in ICUs. Am J Respir Crit Care Med. 2017 Jul 15;196(2):242-245.

Stasa D. Tadic, MD, MSTyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Shachi Tyagi, MD, MSTyagi S, Perera S, Brach JS. Balance and Mobility in Community-Dwelling Older Adults: Effect of Daytime Sleepiness. J Am Geriatr Soc. 2017 May;65(5):1019-1025.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Debra K. Weiner, MDMadill ES, Samuels R, Newman DP, Boudreaux-Kelley M, Weiner DK. Development of an Evaluative, Educational, and Communication-Facilitating App for Older Adults with Chronic Low Back Pain: Patient Perceptions of Usability and Utility. Pain Med. 2019 May 7.

Karp JF, Zhang J, Wahed AS, Anderson S, Dew MA, Fitzgerald GK, Weiner DK, Albert S, Gildengers A, Butters M, Reynolds CF 3rd. Improving Patient Reported Outcomes and Preventing Depression and Anxiety in Older Adults With Knee Osteoarthritis: Results of a Sequenced Multiple Assignment Randomized Trial (SMART) Study. Am J Geriatr Psychiatry. 2019 Oct;27(10):1035-1045.

Vina ER, Hausmann LRM, Obrosky DS, Youk A, Ibrahim SA, Weiner DK, Gallagher RM, Kwoh CK. Social & psychological factors associated with oral analgesic use in knee osteoarthritis management. Osteoarthritis Cartilage. 2019 Jul;27(7):1018-1025.

Hausmann LRM, Youk A, Kwoh CK, Gallagher RM, Weiner DK, Vina ER, Obrosky DS, Mauro GT, McInnes S, Ibrahim SA. Effect of a Positive Psychological Intervention on Pain and Functional Difficulty Among Adults with Osteoarthritis: A Randomized Clinical Trial. JAMA Netw Open. 2018 Sep 7;1(5):e182533.

Karp JF, Gao X, Wahed AS, Morse JQ, Rollman BL, Weiner DK, Reynolds CF 3rd. Effect of Problem-Solving Therapy Versus Supportive Management in Older Adults with Low Back Pain and Depression While on Antidepressant Pharmacotherapy. Am J Geriatr Psychiatry. 2018 Jul;26(7):765-777.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Jacobs ZG, Elnicki DM, Perera S, Weiner DK. An E-learning Module on Chronic Low Back Pain in Older Adults: Effect on Medical Resident Attitudes, Confidence, Knowledge, and Clinical Skills. Pain Med. 2018 Jun 1;19(6):1112-1120.

Hausmann LRM, Youk A, Kwoh CK, Ibrahim SA, Hannon MJ, Weiner DK, Gallagher RM, Parks A. Testing a 63

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

Phillips CL, Rubin S, Zucker-Levin AR, Bauer DC, Shorr RI, Kang Y, Gray SL, Hanlon JT; Health ABC Study. Antidepressant Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study. Ann Pharmacother. 2016 Jul;50(7):525-33.

Eric G. Rodriguez, MD, MPHWright RM, Malec M, Shega J, Rodriguez E, Kulas J, Morrow L, Rodakowski J, Semla T, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part XI: Dementia. Pain Med. 2016 Nov;17(11):1993-2002.

Polsunas PJ, Sowa G, Fritz JM, Gentili A, Morone NE, Raja SN, Rodriguez E, Schmader K, Scholten JD, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part X: Sacroiliac Joint Syndrome. Pain Medicine. 2016 Sep;17(9):1638-47.

Karp JF, DiNapoli EA, Wetherell J, Bolon C, Rodriguez E, Shega J, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part IX: Anxiety. Pain Med. 2016 Aug;17(8):1423-35.

Michelle I. Rossi, MD, MPHChang W, Homer M, Rossi MI. Use of Clinical Video Telehealth as a Tool for Optimizing Medications for Rural Older Veterans with Dementia. Geriatrics. 2018 Jul 30;3(3):44.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Powers BB, Homer MC, Morone N, Edmonds N, Rossi MI. Creation of an Interprofessional Teledementia Clinic for Rural Veterans: Preliminary Data. J Am Geriatr Soc. 2017 May;65(5):1092-99.

Fred H. Rubin, MD

Rubin FH, Bellon J, Bilderback A, Urda K, Inouye SK. Effect of the Hospital Elder Life Program on Risk of 30-Day Readmission. J Am Geriatr Soc. 2018 Jan;66(1):145-149.

Leslie P. Scheunemann, MD, MPHScheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB. Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units. JAMA Intern Med. 2019 May 1;179(5):676-684.

Scheunemann LP, Khalil R, Rajagopal PS, Arnold RM. Development and Pilot Testing of a Simulation to Study How Physicians Facilitate Surrogate Decision Making Based on Critically Ill Patients' Values and Preferences. J Pain Symptom Manage. 2019 Feb;57(2):216-223.e8.

Cunningham TV, Scheunemann LP, Arnold RM, White D. How do clinicians prepare family members for the role of surrogate decision-maker? J Med Ethics. 2018 Jan;44(1):21-26.

Chiarchiaro J, Ernecoff NC, Scheunemann LP, Hough CL, Carson SS, Peterson MW, Anderson WG, Steingrub JS, Arnold RM, White DB. Physicians Rarely Elicit Critically Ill Patients’ Previously Expressed Treatment

Preferences in ICUs. Am J Respir Crit Care Med. 2017 Jul 15;196(2):242-245.

Stasa D. Tadic, MD, MSTyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Shachi Tyagi, MD, MSTyagi S, Perera S, Brach JS. Balance and Mobility in Community-Dwelling Older Adults: Effect of Daytime Sleepiness. J Am Geriatr Soc. 2017 May;65(5):1019-1025.

Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017 Aug;36(6):1472-1478.

Tyagi S, Perera S, Clarkson BD, Tadic SD, Resnick NM. Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used. J Urol. 2017 Mar;197(3 Pt 1):753-758.

Debra K. Weiner, MDMadill ES, Samuels R, Newman DP, Boudreaux-Kelley M, Weiner DK. Development of an Evaluative, Educational, and Communication-Facilitating App for Older Adults with Chronic Low Back Pain: Patient Perceptions of Usability and Utility. Pain Med. 2019 May 7.

Karp JF, Zhang J, Wahed AS, Anderson S, Dew MA, Fitzgerald GK, Weiner DK, Albert S, Gildengers A, Butters M, Reynolds CF 3rd. Improving Patient Reported Outcomes and Preventing Depression and Anxiety in Older Adults With Knee Osteoarthritis: Results of a Sequenced Multiple Assignment Randomized Trial (SMART) Study. Am J Geriatr Psychiatry. 2019 Oct;27(10):1035-1045.

Vina ER, Hausmann LRM, Obrosky DS, Youk A, Ibrahim SA, Weiner DK, Gallagher RM, Kwoh CK. Social & psychological factors associated with oral analgesic use in knee osteoarthritis management. Osteoarthritis Cartilage. 2019 Jul;27(7):1018-1025.

Hausmann LRM, Youk A, Kwoh CK, Gallagher RM, Weiner DK, Vina ER, Obrosky DS, Mauro GT, McInnes S, Ibrahim SA. Effect of a Positive Psychological Intervention on Pain and Functional Difficulty Among Adults with Osteoarthritis: A Randomized Clinical Trial. JAMA Netw Open. 2018 Sep 7;1(5):e182533.

Karp JF, Gao X, Wahed AS, Morse JQ, Rollman BL, Weiner DK, Reynolds CF 3rd. Effect of Problem-Solving Therapy Versus Supportive Management in Older Adults with Low Back Pain and Depression While on Antidepressant Pharmacotherapy. Am J Geriatr Psychiatry. 2018 Jul;26(7):765-777.

Weiner DK, Gentili A, Coffey-Vega K, Morone N, Rossi M, Perera S. Biopsychosocial Profiles and Functional Correlates in Older Adults with Chronic Low Back Pain: A Preliminary Study. Pain Med. 2018 Apr 16.

Jacobs ZG, Elnicki DM, Perera S, Weiner DK. An E-learning Module on Chronic Low Back Pain in Older Adults: Effect on Medical Resident Attitudes, Confidence, Knowledge, and Clinical Skills. Pain Med. 2018 Jun 1;19(6):1112-1120.

Hausmann LRM, Youk A, Kwoh CK, Ibrahim SA, Hannon MJ, Weiner DK, Gallagher RM, Parks A. Testing a 64

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Positive Psychological Intervention for Osteoarthritis. Pain Med. 2017 Oct 1;18(10):1908-1920.

Luiggi-Hernandez JG, Woo J, Hamm M, Greco CM, Weiner DK, Morone NE. Mindfulness for Chronic Low Back Pain: A Qualitative Analysis. Pain Med. 2018 Nov 1;19(11):2138-2145.

Hausmann LRM, Ibrahim SA, Kwoh CK, Youk A, Obrosky DS, Weiner DK, Vina E, Gallagher RM, Mauro GT, Parks A. Rationale and design of the Staying Positive with Arthritis (SPA) Study: A randomized controlled trial testing the impact of a positive psychology intervention on racial disparities in pain. Contemp Clin Trials. 2018 Jan;64:243-253.

Havran M, Scholten JD, Breuer P, Lundberg J, Kochersberger G, Newman D, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult-Step-by-Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part XII: Leg Length Discrepancy. Pain Med. 2016 Dec;17(12):2230-2237.

Wright R, Malec M, Shega JW, Rodriguez E, Kulas J, Morrow L, Rodakowski J, Semla T, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part XI: Dementia. Pain Med. 2016 Nov;17(11):1993-2002.

Maree RD, Marcum ZA, Saghafi E, Weiner DK, Karp JF. A Systematic Review of Opioid and Benzodiazepine Misuse in Older Adults. Am J Geriatr Psychiatry. 2016 Nov;24(11):949-963.

Polsunas PJ, Sowa G, Fritz JM, Gentili A, Morone NE, Raja SN, Rodriguez E, Schmader K, Scholten JD, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part X: Sacroiliac Joint Syndrome. Pain Med. 2016 Sep;17(9):1638-47.

Karp JF, McGovern J, Marron MM, Gerszten P, Weiner DK, Okonkwo D, Kanter AS. Clinical and neuropsychiatric correlates of lumbar spinal surgery in older adults: results of a pilot study. Pain Manag. 2016 Nov;6(6):543-552.

Karp JF, DiNapoli EA, Wetherell J, Bolon C, Rodriguez E, Shega J, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part IX: Anxiety. Pain Med. 2016 Aug;17(8):1423-35.

Rollin M. Wright, MD, MA, MPHDriessen J, Chang W, Patel P, Wright RM, Ernst K, Handler SM. Nursing Home Provider Perceptions of Telemedicine for Providing Specialty Consults. Telemed J E Health. 2018 Jul;24(7):510-516.

Wright R, Malec M, Shega J, Rodriguez E, Kulas J, Morrow L, Rodakowski J, Semla T, Weiner DK. Deconstructing Chronic Low Back Pain in the Older Adult—Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part XI: Dementia. Pain Med. 2016 Nov;17(11):1993-2002.

ACKNOWLEDGMENTSThis report was produced by the Office of Academic Affairs in the Department of Medicine.

EXECUTIVE EDITORNichole Radulovich, MEd, CRAExecutive Administrator

SENIOR EDITOR, FACT-CHECKER, AND GRAPHIC DESIGNKatie NaumanAcademic Affairs Administrator

PROJECT COORDINATORSKristen BagwellWeb Producer

Jane-Ellen RobinetCommunications Coordinator

GERIATRIC MEDICINE CONTENT MANAGERSLorraine PolliniManager of Translational Research Operations for HIV-AIDS

Jake RomanowskiExecutive Administrative Coordinator and Assistant to John W. Mellors, MD

DATABASE DEVELOPMENT AND SUPPORTNemanja TomicDatabase Developer

Photo credits:All photos courtesy of the Division of Geriatric Medicine/Department of Medicine except page 17: Google maps, “ID clinic locations,” accessed October 2019.

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ACKNOWLEDGMENTSThis report was produced by the Office of Academic Affairs in the Department of Medicine.

EXECUTIVE EDITORNichole Radulovich, MEd, CRAExecutive Administrator

SENIOR EDITOR, FACT-CHECKER, AND GRAPHIC DESIGNKatie NaumanAcademic Affairs Administrator

PROJECT COORDINATORSKristen BagwellWeb Producer

Jane-Ellen RobinetCommunications Coordinator

GERIATRIC MEDICINE CONTENT MANAGERSMichelle ArdolinoAdministrative Assistant to Dr. Neil Resnick and Lisa Gundel

Vanessa BenkovichDivision Operations Manager

DATABASE DEVELOPMENT AND SUPPORTNemanja TomicDatabase Developer

Photo credits:All photos courtesy of the Division of Geriatric Medicine/Department of Medicine except page 11: Google maps, “Geriatric Medicine clinic locations,” accessed October 2019.

Department of Medicine 2019 Annual ReportDivision of Geriatric Medicine

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Division of

GERIATRIC MEDICINE

2019

ANNUAL REPORT

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