DISEASE CONCEPT OF ALCOHOLISM AND DRUG...
Transcript of DISEASE CONCEPT OF ALCOHOLISM AND DRUG...
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DISEASE CONCEPT OF ALCOHOLISM
AND DRUG ADDICTION
Mark Publicker, MD, DFASAM
Diplomate. American Board of
Addiction Medicine
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NEURAL CIRCUITRY OF REWARD
Present in all animals
Produces pleasure for behaviors needed for survival:
Eating
Drinking
Sex
Nurturing
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ALL DRUGS OF ABUSE BIND TO THE
NEURAL CIRCUITRY OF REWARD
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SELF-STIMULATION STUDIES
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AMERICAN SOCIETY OF ADDICTION
MEDICINE (ASAM) DEFINITION
Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry
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ADDICTION
An overwhelmingly powerful compulsion to use a substance, with progressively diminished capacity to resist it, despite escalating personal harm
The use is at the expense of natural rewards
The development of a negative emotional state
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RISK FACTORS
40 - 50 % genetic vulnerability (epigenetics)
Trauma, neglect, abuse
Parenting
Peer group
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RISK FACTORS
Drug availability
Stress
Social isolation (especially in adolescence)
Traumatic brain injury
Mental illness:
Bipolar, ADHD, PTSD, Schizophrenia, Anxiety disorders
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ADDICTION AS A DISEASE OF THE
BRAIN
Imaging studies consistently show specific abnormalities in the brain function of addicted individuals
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ALCOHOL SPECT SCAN
Alcoholic brain Normal brain
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HEROIN AND CANNABIS SPECT SCANS
Heroin
Cannabis
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COCAINE PET SCAN
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DISEASE OF MALADAPTIVE*LEARNING
Addiction is the hijacking of the brain mechanisms for
learning and memory.
These mechanisms (brain circuits and chemicals) are there to shape behaviors with that, through rewards and cues,
promote survival
*wrong response to a situation
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ADDICTION AND COGNITION (THINKING)
Addiction as the cause
Pre-existing causes predisposing to addiction
ADHD
Fetal alcohol syndrome
Traumatic brain injury
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ADDICTION AND COGNITION
Cognitive deficits impair ability to benefit from counseling: more sessions, more reinforcement needed, role of Alcoholics Anonymous
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VOLKOW: DOPAMINE AND SALIENCE*
Increases in dopamine are not directly related to reward per se, as was previously believed, but rather to the prediction of reward and for salience
*Salience: motivationally important
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GEORGE KOOB
“Addiction is a cycle of spiraling dysregulation of brain reward systems that progressively increases, resulting in compulsive drug use and a loss of control over drug taking”
Counteradaptive* hedonic** dysregulation
*Opposite of a proper, effective change
**Pleasure
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NEUROADAPTATION
Drugs change the brain’s pleasure and reward balance
The brain has powerful mechanisms to oppose this change,
The counteradaptive action overshoots
Repeated cycles of use lead to long-lasting neuroplastic changes
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ALLOSTASIS
Change to a new, vulnerable state
Activation of stress circuitry
Deficit state: inhibition of brain reward system
Increased reward threshold
Altered hedonic tone
Drugs create the stress that require that they be used to create the very problem that they have created
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Craving and relapse can be triggered by salient cues and stress
Kindling
Stress: foot shock, foot shock
Searching
CRAVING
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STRESS REINSTATEMENT
PARADIGM
Our patient’s lives:
Foot shock, foot shock, foot shock
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Addiction is a chronic, progressive brain
disease
In the course of repeated drug use long-
lasting changes occur in the circuitry
involved in memory, learning, motivation
and reward as well as inhibitory control
Craving and relapse can be triggered by
salient cues and stress
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GEORGE CARLIN
“Just because you got the monkey off your back doesn’t mean that the circus left town.”
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Facebook: @medadditiontreatment
Facebook for the Northern New England Society of Addiction Medicine: @ASAM.NorthernNE
Website: www.markpublicker.com