DNA, RNA, & Protein Synthesis Discovery of DNA DNA Structure DNA Replication Protein Synthesis.
discovery of the structure of dna
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Transcript of discovery of the structure of dna
DISCOVERY OF THE STRUCTURE OF DNA
Hank Oliver and Chelsea Peacock
Frederick Griffith
Discovered the process called transformation
Found a transforming agent that survived heat and change a bacteria to virulent
Oswald Avery and Colleagues
Proved DNA was the transforming compound Used protein-destroying enzymes to destroy proteins, RNA-destroying enzymes to destroy RNA, and DNA- destroying enzymes to destroy DNA. Transformation was stopped when DNA-destroying enzymes were used.
Alfred Hershey & Martha Chase
Performed experiment with T2 bacteriophage
Using radiolabeled proteins and DNA and followed them.
Experiment proved DNA was transforming agent
Rosalind Franklin & Raymond Gosling Worked together to produce the first X-
ray diffraction pictures of DNA Their picture of DNA was stolen by
Watson & Crick to determine the structure of DNA
Erwin Chargaff
The amount of cytosine equals the amount of guanine and the amount of adenine equals the amount of thymine.
Adenine ALWAYS pairs with Thymine; Guanine ALWAYS pairs with Cytosine – Chargaff’s Rule
Maurice Wilkins
Studied the orientation of purines and pyrimidines in DNA
Developed well-defined X-ray diffraction pictures of DNA which led to Watson and Crick’s DNA model
James Watson & Francis Crick First to determine structure of DNA Double helix Chargaff’s Rule Made of sugar-phosphate backbone with
bases hydrogen bonded together holding two strands together
References
Griffith Experiment
http://www.nature.com/scitable/topicpage/isolating-hereditary-material-frederick-griffith-oswald-avery-336
Avery Experiment
http://study-biology.wikispaces.com/DNA+and+Genetic+Information
Hershey & Chase Experiment
http://www.accessexcellence.org/RC/VL/GG/hershey.php
Rosalind Franklin’s X-ray Picture
http://biology.kenyon.edu/courses/biol63/dna-prot/xray.html
Rosalind Franklin Picture
http://askabiologist.asu.edu/Rosalind_Franklin-DNA
Raymond Gosling Picture
http://kingscollections.org/exhibitions/archives/dna/key-individuals/gosling
Image for Chargaff’s Rule
http://www.odec.ca/projects/2004/mcgo4s0/public_html/t2/dna.html
Chargaff Picture
http://sanycao-sbi4u.blogspot.com/2012/02/scientists-great-contributions.html
References
Maurice Wilkins Picture
http://scarc.library.oregonstate.edu/coll/pauling/dna/pictures/portrait-wilkinsmodel.html
Watson and Crick Picture
http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/biomolecules/dna/watson-crick-wilkins-franklin.aspx
DNA Structure
http://library.thinkquest.org/24355/data/details/media/dnastructure.html