Our Mission:

To integrate mobile-diagnostics into clinical care.

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DigiSight Integrates mHealth Data

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DigiSight Works With 13 Ophthalmic Tests Today

Test Mobile Technology

1) Visual acuity (Snellen near-vision equivalent) Mobile application

2) Amsler/Metamorphopsia Mobile application

3) Low light acuity Mobile application

4) Inverse acuity Mobile application

5) Contrast sensitivity Mobile application

6) Inverse contrast Mobile application

7) Low light contrast Mobile application

8) Color discrimination Mobile application

9) Acuity + contrast Mobile application

10) DigiGrid proprietary acuity Mobile application

11) Fundus images (in development) Smartphone Add-on

12) Anterior segment imaging (in development) Smartphone Add-on

13) Continuous IOP (in development) Implantable Device

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The Product: Single, Secure Portal for mHealth

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•  Single Portal unites data feeds from multiple diagnostics to create a complete clinical view of patients

•  Physician-friendly interface for patient examinations

•  Data automatically linked to physician portal through cloud architecture

•  Data is transmitted securely and in HIPAA-compliant way

•  Creates comprehensive data-analytics by integrating all diagnostics Confidential

Use Cases Benefit Clinical Care And Financial Performance

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DigiSight

Platform

Financial/Workflow

Clinical Care

Research

Commercial

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Case Study: High Frequency Monitoring

Completed Clinical Studies to Date

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Name Title Location Sponsor

NEI Intravitreal Ranibizumab For Neovascular AMD: Treat And Extend Vs. Monthly Exams With PRN Therapy

Multiple sites NEI Genentech

LIBERTY A Clinical Trial To Assess The Impact Of Home Monitoring To Decrease The Treatment Burden For Neovascular Macular Degeneration

Retinal Consultants of Arizona (Phoenix, AZ)

Genentech

Diabetic Screening

Camera Phone Telemedicine-based Screening for Diabetic Eye Disease

SCVMC (Santa Clara, CA)

Completed

UCLA Use Of A Mobile Internet Application To Increase Communication Among The Diabetic Patient, Diabetologist And Ophthalmologist

Jules Stein Eye Institute (Los Angeles, CA)

UCLA

Kyung Hee University

Reliability Of The Smartphone-based Electronic Visual Acuity Testing; Applications In Remote Monitoring And Clinical Research Of Macular Pathology

Kyung Hee University (Seoul, Korea)

Kyung Hee University

CPMC Relationship between standard Snellen visual acuity and various tests of near VA

CPMC (San Francisco, CA)

DigiSight

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Clinical and Pilot Trial Partners

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Ophthalmology Is A Great Place To Start

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Concentrated Specialty

•  15,000 ophthalmologists in US •  Diagnose, treat, follow patients •  Efficient decision making process •  Focused adoption strategy

Mobile Is Good For Ophth Dx

•  Many diagnostics are mobile-friendly (eg - VA, Amsler, micro-perrimetry, IOP, refractive error)

Large & Motivated Patient Populations

•  30 million patients with AMD, DR, Glaucoma or Cataracts

•  Loss of sight is one of most feared conditions and is chronic

•  Neurological conditions diagnosed in part by ocular tests

Important Outcomes

•  Blindness is expensive and a major cost for payers and society

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Large Patient Populations

Retinitis Pigmentosa

Retinal Vein Occlusion

AMD

Trauma

Glaucoma

DR/DME

Dry AMD

- 2.0 4.0 6.0 8.0 10.0 12.0 US Patients (MM)

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Team

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Name Past Companies Domain Experience

Doug Foster CEO

Robertson, Stephens Inc., Pequot Capital, Longitude Capital

•  Medical device commercialization

•  Finance

Alison Polkinhorne Vice President Product

Sun Microsystems, Ardent, Ipsilon, NVidia •  Product management •  UI/UX development

Doug Merrell Chief Software Architect

DuPont Company, VI Laboratories, Ardent

•  Software engineering

Ed Kanner Vice President Finance

Ernst & Young LLC, Sanderling Ventures LLC, NEKTAR Therapeutics

•  Finance •  Human resources

Ritu Tandon Senior Business Manager

STEM Leadership, Education Pioneers •  Product management

Jin Li iOS Engineer

IGT, Lucid Design, Reality Digital, Cengage Learning

•  Software engineering

Mike Terry Consultant

Raytheon •  Software engineering

>150 years experience with platform systems and healthcare ventures

Scientific Advisory Board Phil Rosenfeld, MD, PhD Bascom Palmer Eye Institute Miami, FL

Pravin Dugel, MD Retinal Consultants of Arizona Phoenix, AZ

George Williams, MD William Beaumont Hospital Detroit, MI

Larry Singerman, MD Retina Associates of Cleveland Cleveland, OH

Jeffrey Heier, MD Ophthalmic Consultants of Boston Boston, MA

David Boyer, MD Retina Vitreous Associates Los Angeles, CA

K. Bailey Freund, MD VRM Consultants New York, NY

Anne Fung, MD Genentech San Francisco, CA

Neil Friedman, MD Mid-Peninsula Ophthalmology Palo Alto, CA

Allen Ho, MD Mid Atlantic Retina Philadelphia, PA

David Brown, MD Retina Consultants Houston Houston, TX

Peter Kaiser, MD Cleveland Clinic Cleveland, OH

Michael Trese, MD William Beaumont Hospital Detroit, MI

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Conclusion

" Clear Strategy: Be the leading mHealth company for ophthalmology, then expand into other specialties

" Large Market: Over 30mm patients with acute ophthalmic conditions

" Unmet Need: mDx do not integrate into clinical practice; healthcare benefits from integrated data

" Expert Team: Medical device experience, software experience, and the world’s leading ophthalmologists

" Traction: DigiSight integrates 13 tests, used in multiple studies and by major pharma

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Thank You! For Further Information:

Doug Foster dfoster@digisight.net

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