Diagnostic & Treatment Challenges in the Adolescent Patient: Sleep….. Why Bother? Helene A....
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![Page 1: Diagnostic & Treatment Challenges in the Adolescent Patient: Sleep….. Why Bother? Helene A. Emsellem, MD November 6, 2015 MoKan 2015 Sleep Conference.](https://reader035.fdocuments.in/reader035/viewer/2022081506/5697bfa11a28abf838c959b9/html5/thumbnails/1.jpg)
Diagnostic & Treatment Challenges in the
Adolescent Patient:
Sleep….. Why Bother?
Helene A. Emsellem, MD
November 6, 2015
MoKan 2015 Sleep Conference
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Objectives• Brief overview of sleep & sleep needs• What makes adolescent sleep special
– sleep requirements– circadian delay
• Adolescent consequences of insufficient sleep
• Treatment & coping strategies• Politics of school start times• Sleep & the college student/ post-grads• Identifying sleep disorders in teens
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Sleep is mandatory… eventually
SURVIVAL: water, food, air & SLEEP
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What is sleep & what does it do?
• Restores us physically• Resets us
psychologically• We learn during sleep• We grow during sleep• Caloric management is
sleep dependent
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Sleep? .... What happens when we don’t get enough?
• Impaired cognitive function– difficulty with FOCUS, ATTENTION &
CONCENTRATION– irritability– impaired memory– Impaired inhibitory control– subjective sleepiness
- prolonged auditory reaction time- prolonged visual reaction time
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Impaired motor function
– Prolonged motor reaction time
– Tremor – Poor coordination– Blurred vision
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Crashes• Drowsiness or fatigue
is a factor in at least 72,000 crashes each year, killing more than 830 and injuring many others, (NHTSA, 2009).
• Young drivers age 25 or under are involved in more than one-half of fall-asleep crashes.
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Teen driving risks related to:
• Inexperience• Risk taking – limit testing• Maturational changes increasing sleep
needs• Changes in sleep patterns reducing
nocturnal sleep time & circadian disruption• Homework demands, part-time jobs,
extracurricular activities, late night socializing– Brightest and hardest working teens at highest
risk ( M. Carskadon 1990)
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School Start Times & MVAs
• A 1 hour delay in school start times in 1 large county in Kentucky resulted in a 16.5% drop in crash rates for teen drivers over 2 years
• During the same time, the state teen crash rate increased 7.8%
• There was a significant increase in the percentage of students that got at least 8 hours of sleep each night (from 35.7% to 50.0%)
Danner, F. & Phillips, B. (2008) Adolescent Sleep, School Start Times and Teen Motor Vehicle Crashes. Journal of Clinical Sleep. 4(6): 533-535.
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Social Implications of Insufficient Sleep
• Poor school performance• Reduced school “engagement”• Difficulty with interpersonal relationships• Crashes • Impaired judgment• Risk taking behaviors - Substance abuse:
alcohol, nicotine, stimulants• Poor sports performance• Lack of creativity & humor
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Medical Implications:Impaired: immune function → infections
(acne) weight control → obesity BP control → hypertension blood sugar control → diabetes mood → depression
HEADACHES
REM Pressure →
Micro sleeps intruding into the day → Impaired learning!
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Sleep & Metabolism
Purpose of fat: energy storage for survival ~ insulation
Prolonged wakefulness
in primitive days
meant DANGER
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The longer I’m awake the more calories I burn…. Right?
• Prolonged wakefulness →
– Impaired cellular LEPTIN metabolism – appetite (via Ghrelin) Weight gain
Obesity: 20.5% teens (2011-2012, CDC)
linked to: insufficient sleep
24/7 society
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Overlapping Symptoms: Sleepiness & ADHD
• Sleepy children more likely to manifest sleepiness as hyperactivity
• Sleepy teens --- just look sleepy• Cardinal symptoms overlap:
– Difficulty with:• FOCUS• ATTENTION• CONCENTRATION
• Cannot diagnose ADD when sleepy!
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Use of stimulants in sleepy teens misdiagnosed with
ADD/ADHD:
Prolonged wakefulness →Increasing sleep restriction →Increasing irritability &
exhaustion →Worsening school performance
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Sleep RequirementsAges 5 – 12: 10-11 hrsTeenagers: 9.25 hrs! (8.5-9.5)Adults: 7-9 hrs
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What is sleep?
Synaptic Homeostasis Hypothesis:During the day we are building connections ---strengthening synapses
At night we downscale ---restore synaptic homeostasis
---enhance learning
“Sleep is the price we pay for plasticity”
G. Tononi & C. Cirelli, Sleep Medicine Reviews, Vol. 10, no 1:49-62, 2006
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Glial Washing
• Glial supportive cells in the brain• Form the GLYMPHATIC system• Enhanced removal of toxic waste
– Including amyloid proteins assoc with Alzheimer’s
• During slow wave sleep
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REM Sleep• Dreaming• No memories of the dream
process formed• Cognitive cortex off line• Muscle paralysis (atonia)• REM bursts
• LEARNING
Positive effect of sleep on learning does not occur if sleep restricted!!!!
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Matt Walker, personal communication.
Brain Plasticity associated with Learning during Sleep
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How does your brain know
when to turn sleep on?• How many hours you’ve been awake: (Process S)
• Day – night cycle (Process C)
• Body temperature• Circadian rhythm of hormones• Genetics (HLA D1)– are you a night
owl?
•Habit
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Entrainment of Sleep Behaviors
• Regulated bed time
• Bedtime routine• Controlled
environment• Positive
reinforcement
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Loss of Environmental Sleep Cues
Adolescence
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Process S – Building sleep debt
TEENS
Later onset of alertness
Slower build-up of sleepiness
Longer internal day
(>24 hours)Emsellem & Whitely, Joseph Henry Press
Homeostatic sleep drive
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6 pm midnight 6 am 6 pmnoon
Normal sleep phase
10 pm - 7am
Process S (Homeostatic sleep drive)
* Brain thinks forward calculates bedtime from time you wake up + 15-16 hours, then makes you sleepy again
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Process C: clock dependent alertness
Emsellem & Whitely, Joseph Henry Press
Suppression of perception of sleepiness during the day
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Retino-hypothalamic Pathway
• Documented in rat• Receptor = retinal
ganglion cells• Secretes melatonin• Connects to
Suprachiasmatic nucleus
• Aligns brain clock to day-night cycle
• (Process C = clock dependent alertness)
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CLOCK BIOLOGY
Controllable variables: sleep habits
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“Light is a DRUG that promotes WAKEFULNESS”
Charles A. Czeisler, PhD, MD Director of Sleep Medicine Harvard Medical School
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Dim Light Melatonin Onset
4-6 hours before bedtime melatonin
secretion begins and gradually suppresses the
SCN and clock dependent alertness
allowing us to manifest our sleep debt and fall
asleep
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Changes in Sleep with Adolescence Coincide with
Tanner Stages & Progress thru Puberty
Longer internal clock time (24.3 hrs)
Slower accumulation of sleepiness during the day later bedtime & wake-up time
Reduced potency of light as a sleep-wake cue in the morning
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Emsellem & Whitely, Joseph Henry Press
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6 pm6 am
6 pmnoon
Normal sleep phase
Delayed sleep phase
10 pm – 7 am
12 am – 9 am
Net result: can’t fall asleep on time have to get up too early insufficient sleep
Evils of Puberty: Predominant Process S
Delayed Sleep Phase of Adolescence
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Mammalian models
of adolescent phase delay
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Why is This Such a Big Issue in 2015?
• Early school start times
• 24-7 “Lit” Society (electronics in bedroom)
• AP Classes & college stress
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Late Bedtime
LessSleep
WeekendSleep-in
Tired duringschool week
TeenWorld
Adolescent Vicious Cycle
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Consequence of Weekend Sleep-ins
6 pm6 am
6 pmnoon
IDEAL sleep time
Weekend catch up sleep
Brain thinks forward calculates bedtime from time you wake up + 15-16 hours,
then makes you sleepy again
Late sleep-ins reset the circadian clock LATER
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Teen Coping Strategies:
Education: understand forces at play
Control your surroundings: Reduce late-night exposure to
•Light -(orange lens sun glasses)•Sound•Food
Limit caffeine & chocolate intake
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Be organized• Don’t leave homework for late at night
– Or the last minute
• Lay out clothes the night before• Make a “to-do” list & structure after school
time• Keep a diary or journal to clear your head• Charge phone in the kitchen
• Establish a REGULAR sleep-wake schedule
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• Make the bedroom a comfortable, calm place• Have an internet & cell phone sign-off time• Do some yoga / relaxation exercise• Move the TV out of the bedroom• Don’t go to bed hungry
• If sleep doesn’t happen then stay in a “sleep conducive” position in bed with lights out and listen to music/book – set a 15 minute sleep timer
• Keep a sleep log and confess your sleep schedule!
(www.snoozeorlose.com)
Evening Routine
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Reinforce your own sleep scheduleset a reasonable lights out time
limit late weekend sleep-ins arise by 9 AM on weekends
Controlled nappingshort nap after school (20-30 min)
weekend mid-afternoon longer nap
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Enhance Morning Wakefulness
with
• LIGHT, FOOD, Exercise
Daily Exercise enhances sleep
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2014 NSF Sleep in America Poll
Sleep in the Modern Family• Teens don’t meet minimum sleep
requirements• Electronics in the bedroom less sleep• Parents’ poor sleep habits kids’ poor
sleep habits– 26% of parents text during the night
• 45% school aged kids have TV in bedroom• Kids who drink caffeine sleep less• More rules = more sleep
– Older kids less rules
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PARENTS
Set a GOOD EXAMPLE
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Treatment Intervention
Melatonin 200 micrograms at 5 PM to simulate dim light melatonin onset
? ChronotherapyLight therapy
Light visor – 10,000 lux of lightWeekday morningsAt necessary wake up timeLight may make things worse if
used incorrectly!
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Effect of AM Light on Sleep Phase
6 pm midnight 6 am 6 pmnoon 3 AM – 11 AM
11 PM – 7 AM
Core body temp minimum
Light BEFORE Core Body Temperature Minimum will
aggravate phase delay
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Why not use hypnotics to force sleep at the correct
time?
It doesn’t work!
Must try to initiate sleep within the patient’s circadian “window of
opportunity” for sleep
It is critical to “move” the window
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Advocate for CHANGE
• Educate teens and parents• Incorporate sleep education
into health curricula• National Sleep Foundation
School Start Time initiative toolkit
• Politic your school system
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Relationships between hours of sleep & health-risk
behaviors in US adolescent students
• 70% of HS students do not get recommended hours of sleep
• Insufficient sleep in teens associated with:– Physical fighting -- Not exercising– Cigarette use -- Feeling sad or
hopeless– Marijuana use -- Seriously considering– Sexual activity suicide
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Recommendation of CDC
“Public health intervention is greatly needed, and the consideration of delayed school start times may hold promise as one effective step in a comprehensive approach to address this problem.”
McKnight-Eily LR, et al "Relationships between hours of sleep and health-risk behaviors in US adolescent students" Prev Med 2011;
DOI:10.1016/j.ymed.2011.06.020.
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Sleep on Campus
• Split sleep schedule• Delayed sleep phase syndrome
6 pm midnight6 am
6 pmnoon
Normal sleep phase
Delayed sleep phaseDelayed sleep phase
11pm-7am
3am-11am
Reinforced by late weekend sleep-ins
Flexibility to nap – better coping
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Sleep Disorders in Teens
• Obstructive sleep apnea• Narcolepsy• Restless Legs Syndrome• Parasomnias• Insomnia
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Sleepy Teens Differential Dx
Insufficient sleepMedication side effects
Medical disorders
Narcolepsy & primary disorders of alertness
Obstructive sleep apnea
RLS/PLSM
Depression
Substance Abuse
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NARCOLEPSY• Peak age of onset teens thru
20s• Pentad of symptoms
– Sleepiness– Hypnogogic hallucinations– Sleep Paralysis– Cataplexy– Fragmented nighttime sleep
• Must be well-rested for valid diagnostic testing
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Same
patient
@ age
16 & 17
8/11/2014Poly TST 380 minutes
8/12/2014MSLT Sleep Latency REM Latency
7:59 1 1.5 2.59:46 2 17 18.5
12:05 3 6.5 71:46 4 5 24.5
Mean Sleep Latency 7.5Mean REM Latency 13.1Naps with REM 4
8/16/2015Poly TST 472 minutes
8/17/2015MSLT Sleep Latency REM Latency
10:06 1 20 N/A12:00 2 15.35 N/A
2:05 3 9.5 N/A4:04 4 20 N/A6:03 5 20 N/A
Mean Sleep Latency 17Mean REM Latency N/ANaps with REM 0
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Sleep & Mood Disorders
risk of mood disorder in sleep deprived teens
• Mood disorder may disturb sleep onset/maintenance
• Precipitation of RLS/PLMS by SSRIs• Sleepiness as medication
complication frequency of Delayed phase with
Bipolar disorder
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Sleep Apnea in Teens
RISK FACTORS• Overweight / obesity• Tonsil/adenoid enlargement• Retrognathia• Prader Willi syndrome• Neuromuscular diseases• + Family history
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Sleep Apnea in Teens
SYMPTOMS• +/- snoring• Restless sleep• Daytime sleepiness• ADD / ADHD• Depression
EVALUATION• Overnight sleep study (not portable)
End tidal CO2 & special scoring rules
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Sleep Apnea in Teens
TREATMENT• Weight loss• Tonsillectomy • CPAP
• ? Mandibular appliance• ? Mandibular advancement
surgery• ? Apnicure WINX system
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Parasomnias
• Night terrors• Sleep talking• Sleep walking
• Decreased frequency with age
• Recur with stress• Familial predisposition
Differential diagnosis: seizures
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BRUXISM
• May be sufficiently severe to:– Disturb sleep– Cause tooth wear
• Increased frequency with:– Apnea– Medication induced
May require RX
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Restless Leg Syndrome
• Familial occurrence• Childhood/teen onset in some• Check iron levels• Remove offending drugs
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Sleep is as important to health as diet & exercise
The National Sleep Foundation
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