Diagnostic Criteria for Cholangitis

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Share Like Tweet 0 0 Download SocBut tons http://www.m edicalcriteria.com . Unifying Concepts. All rights reserved. Diagnostic Criteria for Cholangitis User Rating: / 33 Poor Best Written by G. Firman MD Wednesday, 27 May 2009 19:00  Diagnostic criteria of acute cholangitis: Tokyo Guidelines  A. Clinical context and clinical manifest ations 1. History of biliary disease 2. Fever and/or chills 3. Jaundice 4. Abdominal pain (right upper quadrant or upper abdominal) B. Laboratory data 5. Evidence of inflammatory response a 6. Abnormal liver function tests b C. Imaging findings 7. Biliary dilatation, or evidence of an etiology (stricture, stone, stent etc) Suspected diagnosis Two or more items in A Definite diagnosis (1) Charcot’s triad (2 + 3 + 4) (2) Two or more items in A + both items in B and item C a Abnorm al WBC count, increase of serum C-reactive protein (CRP) level, and other changes indicating inflammat ion b Increas ed serum ALP, r-GTP (GGT), AST, and ALT levels  Crit eria for sev erity assessment of acute cholangitis: Tokyo Guidelines Severity of acute cholangitis Criterion Mild (grade I ) Moderate (grade I I ) Severe (grade I I I ) Onset of organ dysfunction No No Yes Response to initial medi cal treatment a Yes No No  a Consisting of general supportive care and antibiotics  Definitions of severity assessment criteria for acute cholangitis  Mild (grade I) acute cholangitis “Mild (grade I)” acute cholangitis is defined as acute cholangitis which responds to the initial medical treatment a  Moderate (grade II) acute cholangitis “Moderate (grade II)” acute cholangitis is defined as acute cholangitis that does not respond to the initial medical treatment a and Diag nost ic Cri teri a for Ch olan git is http://www.med icalcri teria.com/sit e/i ndex.php?view=art icle &cat id =54... 1 of 2 19-02-2012 15:18

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is not accompanied by organ dysfunction

 

Severe (grade III) acute cholangitis

“Severe (grade III)” acute cholangitis is defined as acute cholangitis that is associated with the onset of dysfunction at least in any

one of the following organs/systems:

1. Cardiovascular system: Hypotension requiring dopamine >/= 5 ug/kg per min, or any dose of dobutamine

2. Nervous system: Disturbance of consciousness

3. Respiratory system: PaO2/FiO2 ratio < 300

4. Kidney: Serum creatinine > 2.0 mg/dl

5. Liver: PT-INR > 1.56. Hematological system: Platelet count < 100 000 /ul

 

Note: compromised patients, e.g., elderly (>75 years old) and patients with medical comorbidities, should be monitored closelya

General supportive care and antibiotics

 

References:

Lee CC, Chang IJ, Lai YC, Chen SY, Chen SC. Epidemiology and prognostic determinants of patients with bacteremic

cholecystitis or cholangitis. Am. J. Gastroenterol. 2007 Mar;102(3):563-9. [Medline]

1.

Wada K, Takada T, Kawarada Y, Nimura Y, Miura F, Yoshida M, Mayumi T, Strasberg S, Pitt HA, Gadacz TR, Büchler MW, Belghiti J, de Santibanes E, Gouma DJ, Neuhaus H, Dervenis C, Fan ST, Chen MF, Ker CG, Bornman PC, Hilvano

SC, Kim SW, Liau KH, Kim MH. Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines. J

Hepatobiliary Pancreat Surg. 2007;14(1):52-8. [Medline]

2.

 

Created: Jul 16, 2007

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Last Updated on Saturday, 28 January 2012 14:10

 

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