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DIABETIC DYSLIPIDEMIA A MAJOR RISK FACTOR IN

CARDIOVASCULAR DISEASES

Banciu Andreea Maria

Grigore Mihai

Associated Professor: Minerva Boitan

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INTRODUCTION

Over the last 30 years, DM had changed from beeing associated with aging to one of the major causes of premature morbidity in most coutries.

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INTRODUCTION The mechanism by which Diabetes leads to

these complications is complex and not yet fully underderstood, but involves: High glucose levels Abnormal lipid levels

Major Diabetes complications are: Cardiovascular diseases (CVD), nephropathy, retinopathy, amputation.

CVD is the major complication responsable for more than 50 % and up to 80 % of deaths in people with Diabetes

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Cerebrovascular diseases

Retinopathy

Coronary Heart Disease

Nephropathy

Neuropathy

Diabetic foot

Peripheral Vascular Disease

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PROPORTION OF HOSPITAL BED DAYS USED FOR THE TREATMENT OF DIABETIC

COMPLICATIONS

Total cardiovascu-lar diseasesAcute complica-tionsNephropathyRetinopathyNeuropathyOther

Source: International Diabetes Federation, 1999

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MATHERIALS AND METHOD

A retrospective study including 100 patients from Sibiu Country Emergency Hospital 61 men 39 women

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MATHERIALS AND METHOD

Type of Diabetes I – 11 II - 89

Urban 51, Rural 49 Treatment

Insulin 61 Oral Antidiabetes 39

Treatment

InsulinOral An-tidiabetes

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RESULTS

The mean age of the population was 55.52 years

Range: 38 - 69 years By age, the lot was devided in 4 groups:

I (< 40 years) II (40 – 50 years) III (50 – 60 years) – the predominant group IV (> 60 years)

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RESULTS

Group I Group II Group III Group III

Men 1 9 41 10

Women 1 3 26 9

Type I Diabetes 1 3 5 2

Type II Diabete 1 9 62 0

5

15

25

35

45

55

65

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RESULTS BMI (Body Mass Index) calculated by

deviding weight in kilogrammes by the square of height in metres shown that over 60 % of patients had BMI > 30.00 kg/m2, most of them are Type II Diabetes Mellitus patients.

60 % of patients are obese (moderate / severe / very severe)

21 % of patients are overweight (> 25 kg/m2) Mean BMI: 33.45 Mean BMI in men: 31.56 Mean BMI in women: 35.28

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RESULTS

Type I Diabetes Type II Diabetes

< 18.49 1 0

18.50 - 24.99 4 6

25.00 -29,99 3 18

30.00 - 34.99 3 24

35.00 - 39.99 0 19

> 40 0 22

2.5

7.5

12.5

17.5

22.5

27.5

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LIPID PROFILE

58 % of patients had elevated Cholesterol levels

Over 50 % of patients had increased Triglycerides

41 % had increased LDL – Cholesterol 40 had decreased HDL - Cholesterol

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LIPID PROFILE

Cholesterol Triglycerides LDL HDL

Low 0 0 34 40

Normal 42 48 25 29

High 58 52 41 31

5

15

25

35

45

55

65

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CONCLUSIONS Besides Obesity, which is the principal risck

for DM patients, hypertension, hypothyrodism and other comorbidities had a substantial risk for cardiovascular diseases

HypertensionCardiac Insuf-ficiencyGoutHyperthyroidismHypothyroidismPancreatitis

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CONCLUSIONS

CVD is more frequent in men, the group of age between 50 – 60 years.

Type II Diabetes Mellitus is more preditable to a CV risk

Dyslipidemia is influenced by gender (men had more elevated Tryglicerides, decreased HDL – Cholesterol and descreased LDL – Cholesterol, comparing to women who had increased LDL – Cholesterol than men).

The main CVD, possible complications of dyslipidemia of DM patient are: Coronary Heart Disease (41 %), Arteriopathy (16 %), Cerebrovascular Diseases (4 %).

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CONCLUSIONS

Isch

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Perif

eral

Arte

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Cereb

rova

scul

ar D

isea

ses

0

10

20

30

40

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REFERENCES1. American Diabetes Association - American Diabetes Association Complete Guide to Diabetes: The

Ultimate Home Reference from the Diabetes Experts, 2014

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5. DeFronzo R.A - International Textbook of Diabetes Mellitius, Ed. Wiley Blackwell, 2013

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11. Kwiterovich P - The Johns Hopkins Textbook of Dyslipidemia, Ed. Williams, 2009

12. Lilly L – Pathophysiology of Heart Diseases, Ed. Williams, 2010

13. Longo D – Manual of Medicine, Ed. McGraw Hill Proffesional, 2013

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THANK YOU !