Diabetes Part 1
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Transcript of Diabetes Part 1
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Care of Clients with Diabetes Mellitus
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Part 1 - Basics
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ADA Guidelines for Diagnosis
Normal serum glucose: 70-110Diabetes FBS > 126 on 2 occasions Random glucose > 200 with symptoms
Pre-diabetes FBS > 100 Random glucose 140- 200
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Type 1 Diabetes
Autoimmune reaction in which beta cells that produce insulin are destroyed
Genetic predisposition: HLA linkage
Environmental triggers can stimulate an autoimmune response Viral infections: mumps, rubella,
coxsackievirus 3
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Treatment Type 1 Diabetes
DietExerciseInsulinMonitoring
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Type 2 Diabetes- Etiology
Insulin resistanceDecreased production of insulin by
beta cellsLiver releases too much glucoseGenetics
http://www.diabetes.org
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Type 2 Diabetes- symptoms
Few symptoms initially Fatigue Altered vision Nocturia Skin infections, vaginal infections,
poor wound healing
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Type 2 Diabetes Risk Factors
Obesity Family history Over age 45 High-risk ethnic group: African, Native
American, Hispanic Delivery of baby > 9 pounds History of: gestational diabetes,
polycystic ovary syndrome Hypertension
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Type 2 diabeteschildren & adolescents
Incidence on the rise No symptoms in early stage of
disease Symptoms: frequent infections,
weight loss with increased appetite, blurry vision, polyuria, bed wetting
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Acanthosis nigricans
Area of darkened skin & velvety thickening on the child’s neck, armpits, groin, or other areas of skin folds.
Sign of insulin resistance Found in 90% of children with type 2 Most often seen in African American
& Hispanics
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Acanthosis nigricans
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Type 2 diabetes in children
Prevention: Exercise 1 hr/day, healthy diet
Test high risk groups age 10 years or more every 2 years Overweight Family history Hispanic, African American, Asian
American
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Treatment Type 2 Diabetes
DietMonitoring blood glucoseExerciseOral MedicationInsulin
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Gestational diabetes
Last half of pregnancy placenta produces insulin antagonist (human placental lactogen)
Leads to increased placental destruction of insulin
Insulin production needs to increase 2-3 X non- pregnant level
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Gestational Diabetes: Diagnosis
1 hour glucose challenge test using a 50 gram oral glucose if results > 140 mg/dl will have to retest with:
3 hour glucose tolerance test using 100 gram oral glucose: diagnosis confirmed when any 2 or more glucose values are over 140 mg/dl 14
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Gestational Diabetes: Treatment
Blood glucose self-monitoringDietExerciseStress managementPharmacologic therapy: insulin
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Gestational diabetes- effects on infant
Macrosomia- 9.9 lbs or >
Hypoglycemia- for first 72 hours of life Infant accustomed to increase in
glucose which leads to hyperinsulinemia in the infant. At birth the glucose supply from mother is no longer present but infants pancreas continues to produce large amounts of insulin.
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Gestational Diabetes
No longer have diabetes after delivery of infant
Women with gestational diabetes have up to a 45% risk of recurrence with next pregnancy and up to 63% risk of developing type 2 diabetes later in life
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Diet
Food Guide Pyramid www.mypyramid.gov
Carbohydrate Counting 15 gm CHO= 1
exchange 45-60 grams per
meal
Plate MethodExchange List
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Diet education
Initially should be done by dietitian Never skip meals if on oral
sulfonylureas Learn to recognize food portions Alcohol suppresses liver production of
sugar
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Diet Education
Remember: No foods are forbidden for people
with diabetes It’s not carbs the patient should
worry about It’s the amount of carbs consumed Portion control !!!!
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Carbohydrate
Healthy carbs come from fruit, veggies, whole grains, legumes and low-fat milk
Need to monitor intake and divide throughout the day
Sugar is allowed within reason Fiber is recommended
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Food Labels
Locate serving size Locate total grams
of carbohydrate 15 g = 1 carb
choice Ignore sugar
grams
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X
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Exercise
Regular Consistent Aerobic: 30 min/day most days Resistance training: 2-3
times/week Type 1- increases insulin
sensitivity Type 2- wt loss, decrease insulin resistance
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Self-Monitoring of Blood Glucose (SMBG)
Modern meters Small blood volume (0.3 to 4 L) Ability to use alternate sites Shorter results time: 5 to 10
seconds Very accurate if maintained
properly
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Monitoring Glycemic Control
A1C formerly know as Hgb A1C
Blood test measuring glycosylated Hgb A Glycosylation: glucose binds irreversibly
to Hgb A1C reflects mean glucose level past 2-3
months Check every 3-6 months
Normal < 6%Goal for diabetic < 7%
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Targets for Glucose ControlType 1 and Type 2 Diabetes
Fasting/Pre-meal glucose
Post-meal glucose2 hr. after start of
meal
Bedtime glucose
A1C
70-130 mg/dL
<180 mg/dL
100-140 mg/dL
7%
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A1C and blood sugar results
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Insulin Therapy
Type 1- always required
Type 2- during periods of stress, illness, surgery and when all other treatments fail
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Insulin
36% with type 2 diabetes use insulin within 5 years of diagnosis 50%
require Weight gain can be significant: 5-10
kg 1st yr Insulin dose needed varies Most serious side effect is
hypoglycemia
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Terms describing time & effect of insulin
Onset: time span after administration when insulin will begin to effect the blood glucose level
Peak: time span after administration when the insulin will have the greatest effect on the blood glucose level
Duration: time span after administration when insulin will continue to effect the blood glucose level
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Basal & Bolus
Basal Insulin: insulin required to suppress hepatic glucose production between meals
Bolus Insulin: insulin required to maintain normal glucose disposal after meals
Normal process of pancreas in healthy person 31
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Storage of Insulin
Open vial at room temperature 30 days
No direct sunlight Do not store in freezer Keep out of glove compartment Extra vial in door of refrigerator
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Mixing Insulin
Always draw up clear first to prevent contamination of fast acting insulin
Can be pre-drawn and stored in refrigerator for 1 week Store needle upright & agitate
syringe before administering
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Box 18.3 Mixing insulin (Figures only)
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Sliding Scale
Used with intensive insulin therapy and during hospitalization to maintain euglycemia
Accu-check should be no more than ½ hour prior to the administration of the corrective insulin dose
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Sites for injection
AbdomenBack of armMiddle anterior thighUpper buttocks
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Rotation of sites
Insulin injections should be given in the same region at a specific time of day & rotated within that region
Due to difference in absorption rates of sites
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Insulin devises
Insulin pump- receives rapid acting insulin continuously per subcutaneous route
Insulin pen- good for visually impaired and people with problems with dexterity
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Insulin Pumps
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Insulin Pump site
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Insulin Pump: During hospitalization
Have physician write orders to leave the pump in place
Don’t discontinue the pump unless insulin therapy is given IV or subcutaneously
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Insulin Pump: During hospitalization
Patient should change their site every 2-3 days
and
Whenever blood glucose is over 240 mg/dl for 2 tests in a row
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Oral Antihyperglycemic Agentsfor Type 2 Diabetes
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ClassSulfonylureas
Biguanides
Thiazolidinediones
Meglitinides
α-Glucosidase inhibitors
DPP-4 Inhibitors