Diabetes milletes immunopathaogenesis
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Diabetes Milletes Immunopathaogenesis
Dr. Ryad KhanfarBy : Abdelrahman Al-daqqa
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β-Cell-Specific T Cells Are Present in Healthy Individuals but Do Not Attack β Cells
They can then be stimulated by the corresponding autoantigen when it is adequately presented to them in the context of MHC molecules.
Autoantigens : insulin insulin (or proinsulin), GAD, IA.2, a tyrosine phosphatase, and IGRP.
They induce the production of T cells or autoantibodies in NOD mice or diabetic patients.
Regularity T-cells slow down
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Genetics : AIRE , HlA-DR3/4Environmental : i.e ; viral
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Are immunological tests useful?
The autoantibodiesautoantibodies response to islet cell antigens predict the risk of developing IDDM.
The titre of ICAtitre of ICA also is important (if ICA high-> 500 times more likely to develop IDDM) .
However , no available immunological intervention for tom prevent B-cell destruction , so these tests are not effectivenot effective until discovering a new txt !
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Ref .
JOHN B. ZABRISKIE , Essential Clinical Immunology , Cambridge University .
Luheun A, Diana J, Zacconi P, Cooke A. “Immune crosstalk in type 1 Diabetes milletes “, pubmed , 2010 Jul;10(7):501-13. doi : 10.1038/nri2787 .
Diana J, Simoni Y, Furio L , “Cross talk btw neutrophils, B-1a cells and plasmacytoid dendritic cells initiate autoimmune diabetes ”2013 Jan;19(1):65-73. doi: 10.1038/nm.3042. Epub 2012 Dec 16 .
ABBAS , Cellular and Molecular Immunology , 7th edition .
GABRILE VIRELLA , Clinical immunologyClinical immunology , 5th edition
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