Update on Scalable SA Project #OFADevWorkshop Hal Rosenstock Mellanox Technologies.
Dia Care-2014-Rosenstock-dc14-0001.pdf
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Transcript of Dia Care-2014-Rosenstock-dc14-0001.pdf
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Advancing Basal InsulinReplacement in Type 2 DiabetesInadequately Controlled WithInsulin Glargine Plus Oral Agents:A Comparison of AddingAlbiglutide, a Weekly GLP-1Receptor Agonist, Versus Thrice-Daily Prandial Insulin LisproDOI: 10.2337/dc14-0001
OBJECTIVE
GLP-1 receptor agonists may provide an alternative to prandial insulin for advanc-ing basal insulin therapy. Harmony 6 was a randomized, open-label, active-controlled trial testing once-weekly albiglutide vs thrice-daily prandial insulinlispro as an add-on to titrated once-daily insulin glargine.
RESEARCH DESIGN AND METHODS
Patients taking basal insulin (with or without oral agents) with HbA1c 710.5% (5391 mmol/mol) entered a glargine standardization period, followed by randomi-zation to albiglutide, 30 mg weekly (n = 282), subsequently uptitrated to 50 mg, ifnecessary, or thrice-daily prandial lispro (n = 281) while continuing metforminand/or pioglitazone. Glargine was titrated to fasting plasma glucose of