DHA and Reproductiongynecology.sbmu.ac.ir/uploads/DHA_spain_2017.pdf · DHA and Reproduction...
Transcript of DHA and Reproductiongynecology.sbmu.ac.ir/uploads/DHA_spain_2017.pdf · DHA and Reproduction...
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DHA and Reproduction
S.Salehpour
Professor Ob/gyn
Infertility fellowship
Medical director
Gyn ward and IVF center
Taleghani hospital
SBMU
Tehran_ Iran
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What is DHA?
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summary
1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
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1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
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• DHA has neurodevelopmental benefits • DHA can reduce suseptibility to adolescence mood
disorders ( jour of lipid research_2015)
• Diet rich in fatty fish, meats, eggs, fish oil is recommended
for teen ages • Positive role for EPA in the treatment of adult depression (Grosso et al 2014)
• DHA ↑ plasma serotonin and melatonin • Supplementation with DHA is important after weaning ( jour of lipid research- 2015)
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1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
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DHA and spermatogenesis
• DHA ↑ cell membrane flexibility better cell function and maturity
• ↓ DHA in mice ↓ sperm morphology (JBC 2017)
• ↓ DHA ↑ cytoplasm around sperm head • ↓DHA ↓ sperm endocytosis • Level of DHA is increased from spermatogonia to
spermatocyte and might play a role in sperm differentiation
(JBC 2017)
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DHA and seminal plasma
• ↑AA/ DHA in seminal plasma ↑ infertility (clini nut 2010)
• DHA has anti inflammatory effect ( j nutr 2008)
• Antioxidants ↓AA/ DHA ↑ clinical pregnancy rate in IVF
( biomed papmed 2015)
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• DHA restores all impairement of male reproduction
• DHA supplementation restores fertility and spermatogenesis in mice
( j lipid res 2010)
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DHA and oogenesis
• EPA and DHA ↓ ovarian PG E2 enhance ovulation
(science direct 2009)
• DHA supplement ↑PG E3 and PGF 3α in ratsbetter ovulation
( science direct 2009)
• PUFA supplement ↑ steroidogenesis ( j Rep inf 2014)
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• Omega 3 and PUFA supplement better ovulation
(ferti steri supp 2011)
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Effect of PUFA on fertilization in ICSI
PUFA supplement in female
↑ fertilized oocytes
↑ good quality embryos
↑ implantation and pregnancy rate
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DHA and endometriosis
PUFA supplement
• ↓ endometriosis volume
• ↓ interleukin- 6
• ↓ TNF -α
• ↓ VEGF
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1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
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DHA during embryogenesis • PUFA improve brain
development and function ( poult sci 2017) • DHA is incorporated into
brain and retina during the last trimester and first two years of life
• Higher prenatal fish
consumption in pregnancy improvement of neurodevelopment in offspring
• Fish consumption = methylmercury exposure
• Mercury toxicity in pregnancy neurodevelopmental delay in children
(Amj epid 2008)
• Fish consumption ↓ preterm birth ↑ birth weight
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DHA in pregnancy
• Neurodevelopmental benefits
• ? ↓ preterm birth
• ↓ asthma and allergy in offspring ( current opi 2012)
• No decrease in IUGR, preclampsia, GDM (Amj clin nut 2007)
• ? No decrease in peripartum depression ( Br j nut 2010)
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• 200-300 mg /day DHA in pregnancy
• Optimal visual and cognitive development in offspring
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1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
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DHA in menopause
• DHA modulate perimenopausal symptoms and improve quality of life, and sexual life
• DHA improve audiometric indices in perimenopause
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1. DHA and puberty
2. DHA and fertility
3. DHA and pregnancy
4. DHA and menopause
5. DHA and cancers
![Page 25: DHA and Reproductiongynecology.sbmu.ac.ir/uploads/DHA_spain_2017.pdf · DHA and Reproduction S.Salehpour Professor Ob/gyn Infertility fellowship Medical director ... Effect of PUFA](https://reader036.fdocuments.in/reader036/viewer/2022062605/5fcda4ceb2de896b2439c89f/html5/thumbnails/25.jpg)
• DHA consumption during adolescence and midlife
↓ decrease breast cancer
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Thanks for your attention
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