Development of the skin and its derivatives · 2014-08-22 · Skin function and anatomy Skin...
Transcript of Development of the skin and its derivatives · 2014-08-22 · Skin function and anatomy Skin...
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Development of the skin and its derivatives
Dr Annemiek Beverdam – School of Medical Sciences, UNSW Wallace Wurth Building Room 234 – [email protected]
Resources: http://php.med.unsw.edu.au/embryology/
Larsen’s Human Embryology The Developing Human: Clinically Oriented Embryology
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Lecture overview Skin function and anatomy
Skin origins
Development of the overlying epidermis
Development of epidermal appendages:
Hair follicles Glands Nails Teeth
Development of melanocytes
Development of the Dermis
Dr Annemiek Beverdam – School of Medical Sciences, UNSW Wallace Wurth Building Room 234 – [email protected]
Resources: http://php.med.unsw.edu.au/embryology/
Larsen’s Human Embryology The Developing Human: Clinically Oriented Embryology
![Page 3: Development of the skin and its derivatives · 2014-08-22 · Skin function and anatomy Skin origins Development of the overlying epidermis Development of epidermal appendages: Hair](https://reader033.fdocuments.in/reader033/viewer/2022042822/5f99020d186ce06c6f346e51/html5/thumbnails/3.jpg)
Skin Function and Anatomy
Largest organ of our body Protects inner body from outside world (pathogens, water, sun) ThermoregulaMon Diverse: thick vs thin skin, scalp skin vs face skin, etc Consists of: -‐ Overlying epidermis -‐ Epidermal appendages:
-‐ Hair follicles, -‐ Glands: sebaceous, sweat, apocrine, mammary -‐ Nails -‐ Teeth
-‐ Melanocytes -‐ Dermis -‐ Hypodermis
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Trilaminar embryo
Ectoderm (Neural crest) brain, spinal cord, eyes, peripheral nervous system
epidermis of skin and associated structures, melanocytes, cranial connective tissues (dermis)
Mesoderm musculo-skeletal system
limbs connective tissue of skin and organs urogenital system, heart, blood cells
Endoderm epithelial linings of gastrointestinal and respiratory tracts
Skin origins
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Ectoderm Overlying epidermis, epidermal appendages,
nerve endings
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Neural Crest Melanocytes
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Mesoderm Dermis, Hypodermis
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Page 342 S.F. Gilbert Developmental Biology 5th ediMon
Embryonic development:
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Epidermal development Surface ectoderm
Skin/Interfollicular epidermis: straMfied squamous epithelium Appendages:
Hair follicles Glands (sebaceous, sweat, apocrine, mammary, lacrimal, salivary) Nails Teeth
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StraMfied skin/IFE
KeraMn 5/14
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Involucrin Loricrin
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Epidermal Appendages
-‐ Hair follicles, -‐ Glands: sebaceous, sweat, apocrine, mammary, salivary, lacrimal
-‐ Nails -‐ Teeth
Share common developmental mechanisms
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Hair follicle development and cycling Epidermal appendage
Involved in thermoregulation/sun protection
Month 2-‐4: Onset hair follicle development Hair follicles develop first in cranial region
Month 5: most hair follicles present ≈ 5,000,000 hair follicles
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Hair follicle development
Hair germ
Hair peg
Bulbous hair peg
Invasion of dermis cells
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Hair follicle development
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Postnatal hair follicle cycling
Telogen: rest Anagen: growth Catagen: regression
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Epidermal gland development Epidermal appendages
Sebaceous glands: sebrum/vernix
Sweat glands Apocrine glands (‘smelly’ glands)
Mammary glands Salivary glands Lacrimal glands
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Epidermal gland development Epidermal appendages
Sebaceous glands: develop from hair follicle (4 weeks +) Sweat glands: develop from basal layer IFE (20 weeks+)
Apocrine glands: develop in association with HFs, most lost late in fetal dev.
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Mammary gland development Epidermal appendage
4 weeks:
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Nails
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Nail development Ectoderm
Week 10: epidermal thickening, nail field
h`p://discovery.lifemapsc.com/library/review-‐of-‐medical-‐embryology/chapter-‐75-‐development-‐of-‐the-‐nails
Week 11: nail anlagen moves proximally, nail folds, proximal hair fold: formaMon of formaMve zone
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Nail development Ectoderm
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Teeth
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Tooth development Ectoderm/cranial neural crest derived mesenchyme
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Tooth development Week 6: dental lamina forms
Week 7-‐8: formaMon of tooth buds: Bud stage
Week 8: formaMon of dental papilla: Cap and Bell Stage
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Tooth development H"('-"G#<&&<1#
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Melanocytes
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Melanocyte development Neural crest
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Melanocyte development Neural crest
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Melanocyte development Neural crest
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Dermis development Somitic mesoderm
Somatic lateral plate mesoderm Cranial neural crest derived mesenchyme
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Lecture overview Skin
Skin origins
Development of the overlying epidermis
Development of epidermal appendages:
Hair follicles Glands
Mammary glands Nails Teeth
Development of Melanocytes
Development of the Dermis
Dr Annemiek Beverdam – School of Medical Sciences, UNSW Wallace Wurth Building Room 234 – [email protected]
Resources: http://php.med.unsw.edu.au/embryology/
Larsen’s Human Embryology The Developing Human: Clinically Oriented Embryology