DEVELOPMENT OF CONNECTIVE TISSUE Mesenchyme Loose Connective Tissue Mesenchymal Cells Fibroblasts...
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Transcript of DEVELOPMENT OF CONNECTIVE TISSUE Mesenchyme Loose Connective Tissue Mesenchymal Cells Fibroblasts...
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DEVELOPMENT OF CONNECTIVE TISSUE
Mesenchyme Loose Connective Tissue
MesenchymalCells
Fibroblasts
Fibers
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Cell Lineage from Mesenchymal Cells
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TYPES OF CONNECTIVE TISSUE Loose Connective
Tissue Dense Irregular
Connective TissueDense Regular
Connective Tissue
(e.i. mesentery, omentum) (e.i. dermis of skin) (e.i. tendons, ligaments,cornea)
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DENSE IRREGULAR CONNECTIVE TISSUE (DERMIS OF SKIN)
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DENSE REGULAR CONNECTIVE TISSUE
Tendon (longitudinal Section) Tendon (tranverse Section)
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ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL
Internalelasticlamina
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CONNECTIVE TISSUE FIBERS
Collagenous Fibers (bundles)
Reticular Fibers (networks)
Elastic Fibers(anastomosing bundles)
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RETICULAR CONNECTIVE TISSUE
reticular fibers(argyrophilic)
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COLLAGEN
FIBERBUNDLE
FiberFibril
Microfibril
Periodic Bands
Tropocollagen
alpha 1 peptidealpha 2 peptide
TEM of Collagen Fibers SEM of Collagen Fibers
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SCANNING EM OF COLLAGEN FIBER BUNDLES
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procollagen
tropocollagen
ground substance
(mucopolysaccharide)
RER
TEM of Fibroblast and Collagen Bundles
Collagen Types
I - skin, bone, tendon cornea (most common type)II- cartilage, embryonic corneaIII- reticular fibers, loose c.t., blood vessel walls, dermisIV- basal lamina of epithelium
(no fibers, mat of randomly-oriented molecules)
FIBROBLAST
collagen fiberbundles
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TEM OF FIBROBLAST WITH COLLAGEN BUNDLES
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FIXED CONNECTIVE TISSUE CELL TYPES
Fibroblast(fiber producing cell)
Fibrocyte(mesenchymal- pluropotent)
Adipocytes (fat storage)
Fixed Macrophage(histiocyte)
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Adipocytes
fibroblast
Macrophage (light micrograph)
TEM of Macrophage
Fixed Connective Tissue Cells
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MONONUCLEAR PHAGOCYTIC SYSTEM
Mononuclearwanderingcell
coalescence
Giant Cell
Macrophages Osteoclasts Kupffer CellsMicroglial
CellsSinusoidalEndothelia
lymph nodes
bone marrow
connective tissue
lung
serous cavities
spleenbone
resorption
liversinusoids
central nervous system
liver spleen marrow
Monocyte
(reticuloendothelial system)
( all characterized by phagocytic activity)
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LYMPHOCYTES AND PLASMA CELLS (Agents of the immune response)
differentiation stimulated byimmune activation
Lymphocytes Plasma Cells(produce
immunoglobulins-antibodies)
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EOSINOPHILES MAST CELLS
actively phagocyticdestroy immune complexes (antigen-antibody)
Secretion Products:1. Slow-reaction substance of anaphalaxis2. Heparin- anticoagulant3. Histamine- stimulates inflammation4. Serotonin- vasoconstrictor5. Eosinophil Chemotactic Factor
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Connective Tissue Cells
Macrophage
Plasma Cell
Lymphocyte
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TRANSMISSION EM OF AN EOSINOPHILE
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TRANSMISSION EM OF A MAST CELL