Designing your Research Project Designing your Research Project Ivan J Perry Department of...
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![Page 1: Designing your Research Project Designing your Research Project Ivan J Perry Department of Epidemiology & Public Health University College Cor.](https://reader036.fdocuments.in/reader036/viewer/2022082817/56649e6b5503460f94b69c8c/html5/thumbnails/1.jpg)
Designing your Research Designing your Research ProjectProject
Ivan J Perry
Department of Epidemiology & Public Health
University College Cor
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Learning objectives• Understand the nature of science, with particular reference to the
core concept of measurement of causes and effects
• Explain the concept of hypothesis testing in quantitative research and understand the need to specify hypotheses in terms of measurement
• Understand that epidemiological methods provide a conceptual
framework for the conduct of clinical and population based research.
• Understand the need to address bias,confounding and chance in designing your research project.
• Understand the importance of sampling and the concept of target populations, study populations and study samples
• List the major elements to be addressed in drafting a research protocol
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ScenarioScenario
It is suggested that occupational exposure to volatile anaesthetic agents causes depression. You wish to test this hypothesis.
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Seeking to understand the world by a process of observation or experimentation
Measurement - core activity
Measurement of causes and effects or exposures (gene and environment) and disease
To test hypothesis relating cause to effect
Hypothesis must be testable/capable of being disproved or refuted
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In the late eighteenth century, Antoine Lavoisier, introduced the scientific approach to problem solving:
Theory
Hypothesis
Observations or Experiment
Interpretation
Results
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Question or hypothesis: must be clearly stated (descriptive vs.. analytical research) Would qualitative methods be more appropriate?
Science/research: essentially an exercise in measurement
Study design: appropriate to question/hypothesis and feasible?
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Prevalence of Asthma in children with and without pets at home.
Incidence of Diabetes in smokers and non-smokers
Be as specific as possible (e.g. Prevalence or Incidence)
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Quantitative Study Designs
Randomised Controlled Trial
Case ControlCohort
Ecological Cross-sectional
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How will exposure and outcomes be measured?
How will validity (accuracy) and reliability (precision) be determined?
Are established questionnaires/instruments available?
Need for standardised methods to minimise random error (chance) and systematic measurement error (measurement bias).
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Define target population: -to whom will the findings apply
Study Population: -available for study -sufficiently representative of target
population
Study Sample: -representative (in statistical sampling terms) of study population
Concept of sampling: -variation/sampling error
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Study population and study sample?
Methods of sampling: random, stratified, systematic, cluster, convenience.
Representativeness of sample (selection bias).
Methods of recruitment and expected response rate (selection bias)
Sample size (chance, type I and type II errors).
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Data collection methods, questionnaires (interview or postal), physical measurements, blood tests.
Data to be collected (potential confounding variables).
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EpiData/Microsoft Access
Avoid Microsoft Excel
Minitab/SPSS
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Ethics Committee
Informed Consent
Confidentiality/Data Protection
Conflicts of Interests
Research Integrity