Dermal Toxicology Specialty Section What is Dermal Toxicology?The Dermal Toxicology Specialty...
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Dermal Toxicology Specialty Section EOH SIisjointly sponsored by UM D N J– RobertW ood Johnson M edical Schooland Rutgers,TheState University ofNew Jersey. EOH SIisjointly sponsored by UM D N J– RobertW ood Johnson M edical Schooland Rutgers,TheState University ofNew Jersey. What is Dermal Toxicology? The Dermal Toxicology Specialty Section Benefits of DTSS Membership The Officers of the DTSS The Dermal Toxicology Specialty Section provides an opportunity for interactions between scientists involved in skin toxicology, pharmacology and basic skin biology. The areas of research encompassed by Dermal Toxicology include both mechanistic studies of toxicity to the skin itself as well as toxicity to other organs due to absorption through the skin. Of particular interest is the application of these results to the production of risk assessment models for cutaneous exposure to a wide range of potential toxicants, ranging from environmental agents to synthetic chemicals to cosmetics. As results, research within Dermal Toxicology has broad applications in such areas as carcinogenesis, alternative model systems, pharmacokinetics and regulatory issues. In order to promote research within the field, the Dermal Toxicology Specialty Section offers student and post-doctoral awards at the SOT Annual Meeting for accepted abstracts as recognition for exceptional research involving skin toxicology and pharmacology. In the past, a generous contribution from the publishing company, Taylor and Francis, has supplemented these awards with a check and a subscription to Cutaneous and Ocular Toxicology. Awards Awards Networking Networking Access to people in Access to people in the field the field Free membership Free membership President Robert L. Bronaugh, Ph.D. U.S. FDA Interests: The percutaneous absorption and metabolism of topically applied chemicals Vice-President James N. McDougal, Ph.D. Wright State University Interests: skin absorption, molecular biology of skin irritation, systems biology, and biologically-based toxicokinetic models Vice-President Elect David W. Hobson, Ph.D., DABT H&H Scientific Services, LLP Interests:Dermatopharmaceutical R&D, tissue repair and wound healing product R&D, risk assessment and toxicolkinetics / pharmacokinetics Secretary-Treasurer Cindy A. Ryan Procter & Gamble Interests: The development of a cell-based in vitro alternative method for skin sensitization testing Senior Councilor Debra Laskin, Ph.D. Rutgers University Interests: Immunotoxicology, inflammation, and immune mechanisms in liver and lung lnjury Junior Councilor Bill Reifenrath, Ph.D. Stratacor Inc Interests: Topical drug development, models for skin absorption, chemistry of arthropod attractants/repellents Past-President Nancy Monteiro-Riviere, Ph.D. North Carolina State University Interests: Dermatotoxicology, chemical absorption and nanomaterial interactions with skin both in vivo and in vitro Student Representative Adrienne Black Rutgers University Interests: Mechanisms of ultraviolet light signal transduction The skin, as the largest and most visible organ of the body, is subject to constant exposure to a wide range of materials. These materials may be natural or synthetic and can be biological, chemical or physical in origin. The skin itself may be the target of these agents or they may be absorbed into the body to cause toxicity in other organs. Dermal toxicology is, therefore, the study of the adverse reactions of the skin resulting from such exposures. A main focus of the research within the field of dermal toxicology is involved in predicting such reactions when the skin is exposed to a particular agent. Cutaneous risk assessments are a primary tool used in the cosmetics industry as well as determining both occupational and environmental exposures. Dermal toxicology is also a major factor in the development of topical pharmaceuticals. Transdermal delivery of medication requires penetration of the skin barrier so as to maximize absorption while minimizing local irritation and toxicity. The formulation of medications targeted to the skin must also achieve this balance. In addition, the application of materials to the skin must be accounted for in pharmacokinetic models for transport of substances throughout the body. Basic research in skin biology also provides ample opportunities for investigation in dermal toxicology. This research offers a more complete understanding of the molecular mechanisms underlying the processes involved in the generation of these adverse reactions. With this information, improved models could be produced that allow for more accurate predications of potential toxicity as well as provide potential molecular targets for the prevention and treatment of these reactions. Take the Skin Quiz The Skin Quiz The Skin Quiz Why take the Skin Quiz? 1.It’s easy! 2. You’re guaranteed to pass! 3. You don’t have to study! 4. You’ll be registered to win a memory stick! All participants will be entered into a drawing to win a 1 G memory stick. The winner will be announced at the DTSS Annual Meeting on Wednesday, March 5 from 6:00 to 7:30 pm. You have to be in it to win it! www.freeimages.co. uk www.classroomclipar t.com Examples of dermatotoxic materials: Poison Ivy Chemicals Cosmetics and Lotions www.classroomclipar t.com Occupational Exposure www.classroomclipart.com Ultraviolet light www.freeimages.co.uk www.freeimages.co.uk Jewelry
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Transcript of Dermal Toxicology Specialty Section What is Dermal Toxicology?The Dermal Toxicology Specialty...
Dermal Toxicology Specialty SectionEOHSI is jointly sponsored by UMDNJ – Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey. EOHSI is jointly sponsored by UMDNJ – Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey.
What is Dermal Toxicology? The Dermal Toxicology Specialty Section Benefits of DTSS MembershipThe Officers of the DTSS
The Dermal Toxicology Specialty Section provides an opportunity for interactions between scientists involved in skin toxicology, pharmacology and basic skin biology. The areas of research encompassed by Dermal Toxicology include both mechanistic studies of toxicity to the skin itself as well as toxicity to other organs due to absorption through the skin. Of particular interest is the application of these results to the production of risk assessment models for cutaneous exposure to a wide range of potential toxicants, ranging from environmental agents to synthetic chemicals to cosmetics. As results, research within Dermal Toxicology has broad applications in such areas as carcinogenesis, alternative model systems, pharmacokinetics and regulatory issues.
In order to promote research within the field, the Dermal Toxicology Specialty Section offers student and post-doctoral awards at the SOT Annual Meeting for accepted abstracts as recognition for exceptional research involving skin toxicology and pharmacology. In the past, a generous contribution from the publishing company, Taylor and Francis, has supplemented these awards with a check and a subscription to Cutaneous and Ocular Toxicology.
AwardsAwards
NetworkingNetworking
Access to people in the fieldAccess to people in the field
Free membershipFree membershipPresident
Robert L. Bronaugh, Ph.D.U.S. FDA
Interests: The percutaneous absorption and metabolism
of topically applied chemicals
Vice-PresidentJames N. McDougal, Ph.D.
Wright State UniversityInterests: skin absorption,
molecular biology of skin irritation,systems biology, and biologically-
basedtoxicokinetic models
Vice-President ElectDavid W. Hobson, Ph.D., DABT
H&H Scientific Services, LLPInterests:Dermatopharmaceutical R&D,
tissue repair and wound healing product R&D, risk assessment and toxicolkinetics /
pharmacokinetics
Secretary-TreasurerCindy A. Ryan
Procter & GambleInterests: The development of a
cell-based in vitro alternative method for skin sensitization
testing
Senior CouncilorDebra Laskin, Ph.D.Rutgers University
Interests: Immunotoxicology, inflammation,and immune mechanisms in liver and lung lnjury
Junior CouncilorBill Reifenrath, Ph.D.
Stratacor IncInterests: Topical drug development,
models for skin absorption, chemistry of arthropod attractants/repellents
Past-PresidentNancy Monteiro-Riviere, Ph.D.
North Carolina State University Interests: Dermatotoxicology, chemical absorption
and nanomaterial interactions with skin both in vivo and in vitro
Student RepresentativeAdrienne Black
Rutgers UniversityInterests: Mechanisms of ultraviolet
light signal transduction
The skin, as the largest and most visible organ of the body, is subject to constant exposure to a wide range of materials. These materials may be natural or synthetic and can be biological, chemical or physical in origin. The skin itself may be the target of these agents or they may be absorbed into the body to cause toxicity in other organs. Dermal toxicology is, therefore, the study of the adverse reactions of the skin resulting from such exposures.
A main focus of the research within the field of dermal toxicology is involved in predicting such reactions when the skin is exposed to a particular agent. Cutaneous risk assessments are a primary tool used in the cosmetics industry as well as determining both occupational and environmental exposures.
Dermal toxicology is also a major factor in the development of topical pharmaceuticals. Transdermal delivery of medication requires penetration of the skin barrier so as to maximize absorption while minimizing local irritation and toxicity. The formulation of medications targeted to the skin must also achieve this balance. In addition, the application of materials to the skin must be accounted for in pharmacokinetic models for transport of substances throughout the body.
Basic research in skin biology also provides ample opportunities for investigation in dermal toxicology. This research offers a more complete understanding of the molecular mechanisms underlying the processes involved in the generation of these adverse reactions. With this information, improved models could be produced that allow for more accurate predications of potential toxicity as well as provide potential molecular targets for the prevention and treatment of these reactions.
Take the Skin Quiz
The Skin QuizThe Skin Quiz
Why take the Skin Quiz?1. It’s easy!2. You’re guaranteed to pass!3. You don’t have to study!4. You’ll be registered to win a memory stick!
All participants will be entered into a drawing to win a 1 G memory stick. The winner will be announced at the DTSS Annual Meeting on Wednesday, March 5
from 6:00 to 7:30 pm.
You have to be in it to win it!
www.freeimages.co.uk
www.classroomclipart.com
Examples of dermatotoxic materials:
Poison Ivy Chemicals
Cosmetics and Lotions
www.classroomclipart.com
Occupational Exposure
www.classroomclipart.com
Ultraviolet light
www.freeimages.co.uk
www.freeimages.co.uk
Jewelry
