Depth of Penetration by Wavelength...Intense Pulsed Light Nd:YAG Micro= dermabrasion. CO 2 Er:YAG...
Transcript of Depth of Penetration by Wavelength...Intense Pulsed Light Nd:YAG Micro= dermabrasion. CO 2 Er:YAG...
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Depth of Penetration by Wavelength (not to scale)1064
Nd:YAG755
Alexandrite
1540
Er:Glass
1550
Fiber Laser
694
Ruby
585-595
Pulse Dye1440
Nd:YAG2940
Er:YAG
1320
Nd:YAGIntense Pulsed LightMicro=
dermabrasion
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CO2
Er:YAG 1064nm
1320nm IPL
1550nm
Fractional
21st centuryEarly 1980s
PDL
Skin Laxity
RF, IPL
Non-ablative
1440nm
CAP
Ablative
H
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Market Opportunity
• Skin rejuvenation is one of the leading growth drivers in aesthetic medicine.– Over nine million procedures are
performed each year, generating more than four billion dollars in fees for physicians
– The category is forecasted to grow to 11 million annual procedures within five years
– Baby Boomers account for 51% of the US population with an ample disposable income available
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44%of population
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44%of population
70%of US disposable income
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Trends are favorable …
Large number of aging baby boomers in the U.S., Europe and Japan
Skin rejuvenation is now the most popular energy-based aesthetic procedure1
Skin rejuvenation is the second most common procedure after LHR
Skin rejuvenation will experience market-beating growth in procedure volume (4% CAGR) and will be roughly equivalent to LHR by 2017
Skin rejuvenation has very good procedure fees and account for roughly half of all worldwide procedure fees for energy based aesthetic treatments
1. Medical Insight, 2013, p32
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Generation X has a population of 50 million, ages 31-45.
Though their numbers are fewer than Boomers, they lead in cosmetic procedures.
They account for almost 4 million or 42.9% of procedures performed in 2011.
Gen X is more accepting of cosmetic procedures than past generations.
Many consider these procedures simply part of their budget, for personal ‘maintenance’= EASY RETENTION
Who Else Purchases Aesthetic Procedures?
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Fitzpatrick Skin Types
I II III IV V VI
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9/2/10
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Dermatoheliosis
9/2/10
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Solar Elastosis
9/2/10
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SmartSkin CO2
LaserSkinRenewalSM
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Documented Efficacy and Safety in Multiple Publications
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Standard
Skin Resurfacing
Micro-Ablative
Skin Resurfacing
CO2
d
d*
(*) Interlaced scanning to
reduce tissue temperature
increase
(**) Spot pitch
* *
* *
Cmbination of CO2 and micro-ablative technologies
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Standard
Skin ResurfacingMicro-Ablative
Skin Resurfacing
CO2
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Spot pitch – influences how much tissue is ablated
Power – determines the ablation depth
Dwell time – defines lateral thermal effect
How does it work?
Micro-ablative laser skin
renewal
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Clinical Results
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Clinical Results
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Compared with other Fractional
Systems
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•1440nm wavelength is
absorbed ~2-2.5x better
than 1540nm in water
•1440nm confines effect to
the zone of photodamage
~300 mm thick
•Less energy is required for
effective treatment
•Less pain
•Greater safety in peri-orbital
area
1540 nm1440 nm
Unnecessary treated tissue
Wavelength AbsorptionDepth of Penetration
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Service Offerings
• Wrinkle reduction
• Coagulation resulting in tissue
tightening
• Scar and Striae treatment*
• Treatment of pigmentation and
redness Powered By MultiPlex™
1 Pending FDA clearance
• 1440 nm Nd:YAG
• 1320 nm Nd:YAG
• 560 – 950 nm Pulsed Light
Non-ablative skin rejuvenation
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• CAP technology produces
varying levels of heat
distribution in the skin:
– Apex pulses create high
intensity lesions remodeling
collagen
– Low level heating surrounds
the apex pulses creating
collagen stimulation
Apex High
Fluence PulseLow Level Heating
CAP
CAP Technology
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Cross section of 50 year old skin Cross section of 18 year old skin
Epidermis
Photo aged skin~300 µm (dermis)
Healthy skin(dermis)
Epidermis
Healthy skin(dermis)
Photo aged skin: minimal - none
Advantage: Target Tx Approach
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Dermal Tissue Histology
E. Tanghetti, MD / R. Weiss, MD
Columns
Width = 100 µm
Acute
inflammation
Depth = ~1.0 µm
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• Fibrosis creates inflammation
Inflammation in simple terms does the following:
• Inflammatory mediators induce fibroblast and cytokines activity
• Fibroblasts start tissue repair and enhance new collagen production
So the fibrosis causes a would healing response that leads to delayed tissue
contraction because of the inflammation created
Histology Outcomes
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Multiplex Tx
Before Immediately Post 2 Days Post
Co
urt
esy
Dr.
B. B
iesm
an
Skin Laxity
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Micro-thermal Rejuvenation
Baseline 1 Month Post 3 Tx
3.0 J/cm²
Co
urt
esy
Dr.
R. W
eiss
Peri-Orbital Line Treatment with
1440 nm
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Courtesy J. Lloyd, MD Post 4 TX
Clinical Results with 1440 nm
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Acne Scarring
Baseline 1 Month Post 5 Tx
Court
esy A
. M
yers
, R
N
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Micro-thermal Rejuvenation
Baseline 1 Month Follow up 6 Month Follow up
3.0 J/cm²
Co
urt
esy
Dr.
M. G
old
Pigment Reduction with 1440 nm
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1540 Fractional Clinical Results
• Well tolerated treatment
• Mild tolerated pain, no need for anesthetic • Effective collagen shrinkage • FDA-cleared for soft tissue coagulation• Long term collagen growth
• Rapid healing
• 3 to 5 Tx. Intervalls of 14 days apart or more• No infections, bleeding, oozing• No down time – can shave or wash face
immediately • Mild erythema• Mild edema 1-2 days
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Icon – 1540 Specifications
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1540 Fractional Laser Microlenses
4
0
XF™ Microlens
• Extra Fast
• High speed with increased surface coverage
• Allows for a full face, one pass treatment in under 15 minutes
XD™ Microlens
• Extra Deep
• Uses unique lens design to allow for maximum depth of penetration, up to 2mm depth
Imprint of XD
treatment on the skin
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1540 post 3 TX; dr. sinclair, FL
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1540 Fractional Laser Handpiece
Pre-Treatment Post-Treatment: after 4 treatments
Photos courtesy of Dwight Scarborough, MD
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1540 post 3 TX
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Fraxel® DUAL 1550/1927Treatment Overview
• Predictable, reproducible results
• Safe on – All skin types– Anywhere on the body
• Advanced continuous motion handpiece for consistent, even treatment
The Fraxel DUAL 1550/1927 laser is safe and easy to delegate to a trained professional*
*Please check your local regulations
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Skin Reaction Progression 1550 nm - Post 1 Treatment
Before 1550 Treatment Immediately Post 2 Days Post1 Day Post
3 Days Post 1 Month Post5 Days Post4 Days Post
All before and after photos are un-retouched. Results may vary. Courtesy of Solta Medical Aesthetic Clinic
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Skin Reaction Progression 1927 nm - Post 1 Treatment
10 mJ
TL 7 50% Coverage
8 passes
All before and after photos are un-retouched. Results may vary. Courtesy of Solta Medical Aesthetic Clinic
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Clear + Brilliant® OverviewIntegrated Skincare +
Original Perméa™
SkinCeuticals available in U.S. and Canada Markets only
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Patient ProfilesShelly, 26
• Uses skincare products and
sunscreen, gets facials
• Has tried microdermabrasion and
chemical peels
• Doesn’t have textural
irregularities… yet!
“What else can I do for my skin?”
Shelly needs to be proactive in her skin care:
•Continue current skin care regimen
•Add Clear + Brilliant® treatments to microdermabrasion
Model, not an actual patient
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Patient ProfilesJeanine, 31
• Wants radiant skin with minimal
downtime
• Doesn’t want to use injectables
• Getting all she can from
chemical peels
“I want more but don’t have a lot of free time. What can I get for a radiant glow?”
Jeanine needs elevated continuum of care:
•Continue current skincare regimen
•Add Clear + Brilliant® treatments to chemical peels
Model, not an actual patient
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Patient ProfilesSarah, 37
• Takes care of her skin, but
has years of photo damage
• Is new to laser procedures
• Wants long term results with little
downtime
“I have some sun damage. Is there anything I can do to even out my tone?”
Sarah needs a comprehensive regimen:
•Continue at home skin care
•Clear + Brilliant® Perméa™ treatments
Model, not an actual patient
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Patient ProfilesDiane, 43
• Uses professional skincare products
• Started Botox®/fillers a few years ago
• May benefit from a more aggressive
treatment
“I’m not ready for a big laser treatment just
yet – is there something else you can offer me?”
Diane needs a treatment to bridge the gap:
•Continue current skin care regimen
•Supplement Botox®, fillers with Clear + Brilliant®
Model, not an actual patient
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Patient ProfilesCaroline, 50
• Uses professional skin care
products, Botox®/fillers and peels
• Received a series of Fraxel® laser
treatments in the past
“I need a refresher for my skin.
Is there an affordable option?”
Caroline needs maintenance care:
•Continue current skin care regimen
•Offer Clear + Brilliant® to maintain results from Fraxel
Model, not an actual patient
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Managing Patient ExpectationsTreatment Experience
• Multiple treatments are ideal
– Spaced 2-4 weeks apart
• Maintenance treatments, as desired
• Appointment will take approximately
35-60 minutes Depends on treatment area(s)
– Topical anesthetic agent: 15-30 min
– Procedure time: 20-30 min
Most patients describe an increased sensation of heat or
“prickling” during treatment
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Managing Patient ExpectationsResults
• Uniform skin tone
• Improved texture
• More radiant skin
• Minimized pore size appearance
• Skin that looks and feels clear and brilliant
• Immediate and progressive – improves over
multiple treatments
In a clinical study, 100%* of patients
reported improvements in their skin
*Data on file. N=28; 100% reported improvements after 5 treatments Model, not an actual patient
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Clear + Brilliant® ResultsHealing Progression Photos
Before
Before and after photos have not been retouched. Individual results may vary.
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Immediately
Post Treatment
“Felt redness very next day and
felt dryness for a while”
“A little puffy around my eyes”
“A little red and rough to the
touch”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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1 Day
Post Treatment
“Skin peeling and no dryness”
“Skin has a rough texture”
“Skin feels a bit scaly”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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2 Days
Post Treatment
“Skin is much smoother”
“Rough skin starting to flake off”
“Complexion is starting to look
better”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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3 Days
Post Treatment
“Brightened skin tone”
“Make-up goes on so much
smoother!”
“Skin just looks better”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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4 Days
Post Treatment
“Clearer skin and pores are
tighter”
“Skin is much smoother”
“There is a glow to my skin!”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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1 Week
Post Treatment
“Short downtime & smoother
skin after treatment”
“Everything just looks better”
“Tone is even, more natural!”
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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2 WeeksPost Treatment
Clear + Brilliant® ResultsHealing Progression Photos
Before and after photos have not been retouched. Individual results may vary.
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Before and after photos have not been retouched. Individual results may vary.
Clear + Brilliant® Perméa™ ResultsBefore and After Photos
Before Perméa (followed by C E Ferulic®) 1 Week Post 6 Treatments
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Clear + Brilliant® Perméa™ ResultsBefore and After Photos
Before Perméa 1 Week Post 6 Treatments
Before and after photos have not been retouched. Individual results may vary.
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• 755 nm, 532 nm, 1064 nm
• 550-750 picosecond pulse duration
• Boost™ for 70% pressure increase
• FOCUS™ Lens Array
No other pico laser has all this!
PicoSure® Product Overview
Broad US FDA clearances:
PicoSure 755 and 1064 are FDA cleared to treat tattoos and pigmented lesions in
skin types I-VI. PicoSure 755 with Focus is FDA cleared to treat pigmented
lesions in skin types I-VI and acne scars and wrinkles in skin types I-IV.
PicoSure 532 is FDA cleared to treat tattoos in skin types I-III.
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• Diffractive lens redistributes and delivers 755 nm energy
• Low and high intensity energies lighten unwanted pigment
• High intensity energy leads to LIOBs, Pressurewaves, cell signaling and dermal remodeling
Focus™ Lens Array
• Only PicoSure’s unique injury can trigger temporary cell membrane permeability,
enhanced inflammation, increased collagen & elastin, with virtually no downtime
LIOB
Focus
Increased Collagen and Elastin
Reduced Unwanted Pigmentation
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Focus™ uniquely creates intra-epidermal injuriesactivates pressurewaves and cell signaling
Images courtesy of Emil Tanghetti, MD
LIOBs after a single pulse viewed via Confocal Microscope
LIOBs
100x mag.
LIOB
Focal injuries
Dermal
inflammation
10 min post
24 hrs post
24 hrs post
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How does Focus compare histologically?
Fraxel Restore dual non-ablative
Fraxel Repair CO2 ablative
PicoSure Focus
Columns of thermal injury, epidermal injury, and open lesions Elegant injury limited to
the epidermis, no open
lesions, and virtually no
downtime
1550nm 1927nm 755nm10600nm
Courtesy of Bob Weiss, MD and Emil Tanghetti, MD
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Collagen & Elastin ~ 6 months after 4 Focus Tx
Blue stain shows increased
collagen deposition
Courtesy of David McDaniel, MD
Before After
Gray stain shows
increased density of
elastin fibers
Before After
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Focus Lens Array
Pre Immediate Post 3 hours Post 24 hours Post
Impressive Results with Minimal Discomfort/DowntimeImages courtesy of D. McDaniel, MD
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Pigment & Acne Scar Treatment
Before After 4 Focus Tx
Courtesy of Emil Tanghetti, MD
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Pigment Treatment
Courtesy of Lisa Espinoza, MD
Before After 4 Focus Tx
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Wrinkle & Pigment Treatment
Courtesy of Emil Tanghetti, MD
Before After 2 Focus Tx
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Skin Revitalization
Courtesy of F. Tseng, MD
Before After 1 Focus Tx
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Pre Immediate Post 3 hrs Post 24 hrs Post
4 Days Post 1 Week Post2 Days Post
TraditionalFractional
CO2
Photo series 1 and 3 courtesy of David McDaniel, MDPhoto series 2 courtesy of Solta Medical Aesthetic Center
PicoSureFocus
Pre Immediate Post 24 hrs Post
TraditionalNon-ablative Downtime
Downtime
1
2
3
3 Days Post
Downtime
No downtime Skin RevitalizationUniquely stimulate your skin refreshing processes
Lighten unwanted pigment and discolorationIncrease collagen, elastin and skin reflectivity
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THE CHALLENGE – NON-ABLATIVE VS. ABLATIVE
2-5 days downtimevs.No to minimal downtime
Immediate resultsvs.Progressive results
Look years youngervs.Look refreshed
Operator: MD, DOvs.Operator: NP, PA or DO, MD
Non-ablative Ablative CO2
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Aging gracefully is 20% Nature
and 80% Nurture
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