Department of Neurology University of Pittsburgh School of Medicine

University of Pittsburgh Physicians

2017 Annual Report

Annual Report for the Period July 1, 2016 through June 30, 2017

TABLE OF CONTENTS

Department Overview/Mission/Activities 1

Department Educational and Clinical Activities 6

Department Division Activities 13

Department Institutes and National Center Affiliations 26

Research and Scholarly Activities 32

Faculty Summaries by Division

Cognitive and Behavioral Neurology 33

Epilepsy 34

General Neurology 41

Headache Division 45

Movement Disorders 48

Neurocritical Care 54

Neuroimmunology/MS 56

Neuromuscular Diseases 58

Neuro-Oncology 61

Research Division 62

Vascular Neurology 70

St. Margaret’s/McKeesport 75

Northshore – Erie 76

Heritage Valley 78

Faculty Service on Study Sections and Advisory Committees 80

Department Grant Activity 93

Grant and Funding Information 94

Faculty Research Collaborations 102

Faculty Honors, Editorial Service and Professional Affiliations 114

Faculty Mentoring and Teaching Contributions 139

Members of the Faculty 140

House Officers 142

Research Mentoring 146

Graduate Level Teaching, Mentorships, and Service 154

Medical School Teaching, Mentorships, and Service 156

Grand Rounds and Special Lectures 162

Bibliography 168

Financials 220

Department Overview, Mission and Activities

Introduction

The Department of Neurology continues to advance its mission, capabilities, and reputation for academic, clinical

and research activities. We strive to foster a working environment that supports and encourages the development

and growth of our faculty and staff's professional careers. From July 1, 2016 through June 30, 2017, there were 63

faculty members with primary appointments in Neurology and we expect additional faculty to join us next year. The

Department welcomed Drs. Erin Canale, Cynthia Kenmuir, Karuna Mandava, Robyn Massa, Ajitesh Ojha, Athur

Sonberg, Cosmin Sandulescu, and Ahmed Yassin with a variety of specialties in General Neurology, Epilepsy, and

Neuromuscular. Secondary appointments are held by Bing Wang, MD, PhD, Mary Ganguli, MD, William Klunk,

MD, PhD, Robert Sweet, MD, Cheryl Bernstein, MD, James Becker, PhD, Nancy Minshew, MD, Brian Jankowitz,

MD, Udai Pandey, PhD, and Charles Reynolds, MD in recognition of their clinical and research interactions with

the Department of Neurology. Many faculty members maintain secondary appointments throughout the University

providing clinical and research collaborations.

The Department continues to make significant advances in patient care, teaching, and clinical and basic research,

consistent with the mission of the Neurology Department, the School of Medicine, and University of Pittsburgh

Physicians (UPP). Key areas of excellence include the UPMC Stroke Institute; the UPMC Headache Center; the

Alzheimer’s disease Research Center (ADRC); the Pittsburgh Institute for Neurodegenerative Diseases (PIND); and

the American Parkinson Disease Association Advanced Center for Parkinson’s Research. The Neuromuscular,

Epilepsy, Headache, Cognitive and Behavioral Neurology, Stroke, Movement, Neuro-immunology/Multiple

Sclerosis, Women’s Neurology and General Neurology divisions provide key clinical diagnosis and treatment.

We are committed to providing compassionate, comprehensive, timely and high quality service to our patients. Our

clinical faculty receives a large number of referrals for sub-specialty care from community neurologists, other

community specialists, and other clinical department faculty physicians.

Our clinical and research faculty value the role of providing education and support for future physicians and

researchers. We provide our residents, medical students, graduate students and postdoctoral student researchers with

an enriched and supportive professional environment that creates a high-value educational experience. The

Department conducts weekly Neurology Grand Rounds; our program in 2016-2017 featured 34 lectures, 3 of whom

were Visiting Professors from other institutions. We also had 3 Neurology & Neurosurgery Combined Grand

Rounds, 14 Resident Presentations, 9 In-House presentations and 5 presentations from other departments at

UPMC. In addition, multiple conferences and lectures were overseen by our clinical divisions or research centers.

The department also co-sponsors special lectures through PIND, the ADRC and in conjunction with the Department

of Medicine and Neurosurgery.

Clinical research activities benefit our current patients, allow access to cutting-edge therapeutic trials, and provide

significant advances in the overall field of clinical neurology and our clinical research programs have grown

significantly. We develop, maintain, and promote innovative and integrated research programs that promote

fundamental discoveries in basic science areas.

The Department of Neurology faculty and staff are very involved with medically related organizations on the local,

national, and international levels. This involvement extends beyond the medical realm to groups providing support

to patients and caregivers, organizing and supporting fundraising efforts for voluntary health organizations and

raising awareness of neurological diseases. Many of our faculty members and staff have national leadership positions

on NIH advisory or research review committees, in voluntary health organizations, and professional societies.

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Leadership

Lawrence Wechsler, M.D., Chair of the Department of Neurology is professor of Neurology and

Neurological Surgery at the University of Pittsburgh School of Medicine and is former director of the

University of Pittsburgh Medical Center (UPMC) Stroke Institute. He also serves as Vice President

for Telemedicine in the Physician Services Division. Prior to assuming the chair position, Dr.

Wechsler served as Vice Chair for Clinical Affairs and maintained oversight of all clinical operations

within the department. Under his direction the neurology department has continued to expand both

its clinical operations and research activities. Dr. Wechsler’s interests include acute stroke therapy, imaging

and telemedicine. He has participated in many clinical trials of treatments for stroke as an investigator or member

of the steering committee. He was Editor in Chief of the Journal of Neuroimaging from 1999-2007. Dr. Wechsler

holds memberships in several organizations, including the American Neurological Association, American Stroke

Association, American Society of Neuroimaging and the American Academy of Neurology. Dr. Wechsler has

authored or co-authored numerous articles related to stroke and stroke therapy. At UPMC, Dr. Wechsler developed

and implemented the telemedicine program for acute stroke assessment. Beginning in 2006, telemedicine has been

implemented in all UPMC system hospitals to provide access to acute stroke assessment and treatment by faculty of

the UPMC Stroke Institute. Additionally, several other non UPMC facilities are now utilizing telemedicine similarly

for stroke care.

There are 4 vice chairs in the Department of Neurology:

Steven H. Graham, M.D., Ph.D. is Professor of Neurology and Vice Chair for Research. He directs

the operations of the Research Division. Chief among his responsibilities is recruiting world-quality

researchers to an expanding basic science program. Dr. Graham is an accomplished researcher in

neuronal cell death following ischemic injury. He is Associate Chief of Staff for Research for the

Pittsburgh VA Healthcare System and is the Director of the Geriatric Research Educational and

Clinical Center, the major focus of which is cerebrovascular disease.

Paula Clemens, M.D. is Professor of Neurology and Vice Chair for Veterans Affairs. She is Chief

of the Neurology Service at the Pittsburgh VA Healthcare System, responsible for clinical care and

teaching at the VA. She is also an accomplished researcher in clinical and basic studies of treatments

for disorders of skeletal muscle, one of an elite group of researchers who utilize gene therapy in the

experimental treatment of neuromuscular diseases.

Tim Greenamyre, MD, PhD is Professor of Neurology and Vice Chair for Academic Affairs, UPMC

Endowed Chair in Movement Disorders and Director of the Pittsburgh Institute for Neurodegenerative

Diseases. Dr. Greenamyre’s research focuses on the cause of Parkinson’s disease and he is the

Director of an NINDS Program Project Grant entitled “Mitochondrial Proteins in Parkinson’s Disease”

Maxim Hammer, MD is Associate Professor of Neurology and Vice Chair of Clinical Affairs and

Director of Inpatient Services, which involves oversight of inpatient neurological care at many UPMC

hospitals, and Director of Stoke Services at UPMC Mercy Hospital. Dr. Hammer oversees all aspects

of inpatient and outpatient clinical care. His research interests lie predominantly in novel approaches

to acute stroke.

Additional leadership is provided by the Executive Committee: the Department Chair; Vice Chairs; the Division

Chiefs; and Patrick Conway, Department Executive Administrator; Leslie Dunn, Academic Administrator; and Mary

Ann Mirzabeigi, Clinical Administrator.

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Research Activities

The Department of Neurology has a sustained commitment to excellence in the three major components of

academic medicine: teaching, clinical care and research that advances medical knowledge and therapy. Research

funding for clinical, basic, and translational studies in the department has increased steadily over the past few

years and in FY 2017 the department received $14,534,661 in Extramural Research Grant Support and $1,094,550

in Industry Clinical Trial Support.

Basic Research

The Department of Neurology has a strong basic science research program that aims to understand the molecular

mechanisms of neurological diseases and develop new treatment strategies for these disorders. The department’s

basic research program includes the Pittsburgh Institute for Neurodegenerative Disorders, the Alzheimer’s Disease

Research Center and the Geriatric Research Education and Clinical Center. Other areas of focus include

neuromuscular disorders, traumatic brain injury and epilepsy.

Neurology faculty secured funding for a number of new research projects in FY17, including:

• Dr. Edward Burton received funding for a seed grant from the Aging Institute of UPMC Senior Services to

study the pathophysiology underlying age-related neurological diseases such as Parkinson’s disease.

• Dr. Jun Chen received funding for an R01 from NINDS. The project, “Inducible DNA Repair in Cerebral

Ischemia” will test the hypothesis that enhancement of FEN1-dependent DNA repair activity improves long-

term neurological outcomes after cerebral ischemia by promoting the repair process of injured neurons and

white matter.

• Dr. Roberto DiMaio received funding from RIMED Foundation. Selective NOX2 Inhibitor in the Prevention

of Parkinson Disease-Related Neurodegeneration and Movement Disorder to explore and define the role of

NOX2/mitochondria interplay in iPD and models thereof.

• Dr. Steven Graham received funding from the NIH NIHDS for a new R01. The project explores the role

of the neuron specific ubiquitin ligase/hydrolase protein UCHL1 in axonal function and repair in traumatic

brain injury. Novel brain permeable UCHL1 TAT fusion proteins that repair axons will be tested in vitro

and in vivo.

• Dr. Timothy Greenamyre received funding Biogen Pharmaceuticals for Testing Parkinson’s Therapeutics

in Novel Animal Model to study the hypothesis that a brief exposure to a pesticide, like rotenone, such as

one might get occupationally, or even with intensive home gardening, might set off a cascade of pathological

events that could lead – after a prolonged period of neurological normalcy – to development of PD.

• Dr. Timothy Greenamyre received funding from the Blechman Foundation for Clenbuterol Project to

develop proof-of-concept for the prioritized hit, the β2AR-agonist clenbuterol, in a novel progressive model

of endogenous synucleinopathy and Parkinsonism.

• Dr. Timothy Greenamyre received funding for an R21 from NINDS. A Slowly Progressive, Endogenous

Synucleinopathy Model of Parkinson’s Disease to characterize and further develop a novel, progressive

model of Parkinson’s disease.

• Dr. Milos Ikonomovic received funding for an R01 from NIA. Development of a PET Tracer Selective for

Cerebral Amyloid Angiopathy to design, produce, and characterize novel compounds for labeling toxic

deposits of amyloid-beta peptide in brain blood vessels, for use in future imaging studies in living patients.

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• Dr. Emily Rocha received funding from the Parkinson’s Foundation. Loss of Glucocerebrodidase Increase Dopaminergic Neuronal Vulnerability by Impairing Autophagic Flux to test the hypothesize that reduced

GCase activity causes autophagic impairment and is implicated in the pathogenesis of PD. This project will

provide insight into the mechanism that impairs autophagic flux and promotes α-synuclein accumulation in

PD and test the translational potential of GCase.

• Dr. Shanshan Song received funding from American Heart Association, Targeted Knockout of Microgial

Na+/H+ Exchanger-1 in Mice Improves Neurological Function Recovery After Stroke to investigate effects

of selective deletion of microglial Nhe1 in Cx3cr1-CreER;Nhe1f/f mice on neuroinflammation and tissue

repair after ischemic stroke.

• Dr. Dandan Sun received funding from NINDS for a new R01, Liberation of Intracellular Zinc and Neuronal

Cell Death. The project tests the hypothesis that interfering with a cellular process that trigger the Kv2.1-

mediated apoptotic K+ current surge may provide an effective, highly specific therapeutic strategy for

neuroprotection in stroke and related injury.

Clinical Research

Clinical research in the Department of Neurology continues to expand and significant numbers of patients with

neurologic diseases are enrolled in ongoing clinical trials. This is an invaluable resource for continued development

of research in the department, and attracts patients to our medical center. The clinical research program includes

two major research centers: The UPMC Stroke Institute and the NIA-funded Alzheimer’s Disease Research Center

(ADRC). Other areas of clinical research concentration include epilepsy, multiple sclerosis, headache and

neuromuscular disorders.

• Dr. Sara Berman is the site project director for the Dominantly-Inherited Alzheimer’s Network (DIAN)

NIA grant and is the site project director for the first DIAN treatment trial in FY 17. She continued this work

with the Grifols multicenter, randomized, controlled study to evaluate the efficacy and safety of short-term

plasma exchange followed by long-term plasmapheresis with infusion of human albumin combined with

intravenous immunoglobin in patients with mild-moderate Alzheimer’s disease and initiated a new trial with

Lundbeck in patients with mild to moderate AD.

• Drs. Paula Clemens and Larry Wechsler are the Directors of the University of Pittsburgh site in the

NINDS-funded NeuroNEXT, a national clinical trials network established to coordinate Phase 1-2

neuroscience clinical trials and Stroke Net.

• Dr. Paula Clemens is the site project director for the Pompe Study. The purpose of this study is to deterimine

if co-administration of investigational new drugs ATB200 and AT2221 is safe in adults with Pompe disease.

• Dr. Paula Clemens is the site project direct for the AMICUS study, “Open-label, Ascending-Dose, First-in-

Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Intravenous Infusions of ATB200

Alone and ATB200 Co-administered with Oral AT2221 in Adult Subjects with Pompe Disease who were

Previously Treated with Alglucosidase alfa”.

• Dr. Paula Clemens received funding from TRiNDS LLC for a Phase II, Dose Finding Study to Access the

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NS-065/NCNP-01 in Boys with Duchenne

Muscular Dystrophy. University of Pittsburgh is the coordinating center..

• Dr. Islam Zayden is the site P.I. for the Open-Label, multicenter, expanded access program for Ocrelizumab

in patients with primary progress Multiple Sclerosis study. The purpose of this study is to collect safety data

and to monitor the clinical conditional of patients with PPMS who are taking ocrelizumab based on MRI,

EDSS score, or clinical judgment.

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• Dr. Oscar Lopez is the Director of the NIA-funded Alzheimer Disease Research Center (ADRC), which has

been successfully renewed through 2020. He completed a project examining amyloid deposition, vascular

disease and clinical progress of AD. He is also the project leader on a PiB PET imaging Program Project

Grant. In FY 15 he completed a trial (Cytox) comparing the functional integrity of the mTOR pathway with

the PET scan amyloid status (positive or negative) in subjects with a diagnosis of MCI. Several

pharmaceutical trials to improve function in patients with AD are being conducted. New studies have been

initiated in FY 15 with Avid and studies conducted under the NIA-funded Alzheimer’s Disease Cooperative

Study.

• Dr. Oscar Lopez, Co-I, received funding from Cleveland Clinic for a U01. Biomarkers for the Lewy Body

Dementia. This study enrolls subjects that have a baseline evaluation and at least two years of follow up data

and biofluid collection. The study will evaluate motor and behavioral evaluations.

• Dr. Oscar Lopez is the site PI for the ADNI 3 study. This study continues the previously funding ADNA-1,

ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia

and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical

biomarker characteristics of the entire spectrum of Alzheimer’s disease (AD). The overall goal of the study

is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in

AD research.

• Dr. Oscar Lopez and Dr. Beth Snitz received funding for an R01 from NIA. Role of Midlife Cardiovascular

Disease on Alzheimer’s Pathology and Cerebrovascular Reactivity in the Young-Old to further the

understanding of the relationship between AD pathology and neurodegeneration, cerebrovascular reactivity

and midlife CaVD.

• Dr. Ayra Puwanant received funding from MDA. Sub Regional Body Composition and Clinical Endpoint

in Myotonic Dystrophy to test the hypothesis that sub-regional LTM in the preferentially affected muscles

may provide a sensitive endpoint that can be bridged to meaningful clinical outcomes for clinical trials in

DM. The study cohort involves 20 individuals with DM1 and 20 individuals with DM2, and 20 age-matched

healthy individuals.

• Dr. Beth Snitz received funding from NIH for an R01. Alzheimer Neuroimaging-Biomarkers in Pre-Clinical

Cognitive Decline from a Population-Based Study to will investigate in vivo brain imaging of the two

neuropathological hallmarks of Alzheimer Disease (AD) in older adults evidencing pre-clinical cognitive

decline. Appling these imaging tools to a carefully selected and characterized group of recruited participants,

leveraging at least four years of serial, annual cognitive data from a population-based study to define pre-

clinical cognitive decline.

• Dr. Beth Snitz, Co-I, received funding on R01 from NIH. Connectomics of Brain Aging and Dementia to

implement the HCP LifeSpan imaging protocol, and will use the HCP behavioral and cognitive assessments.

• Valerie Suski is the site P.I. for the RESTORE study (a clinical study of patients with symptomatic

neurogenic orthostatic hypotension to assess sustained effects of Droxidopa therapy). The purpose of this

study is to evaluate the time to treatment in patients with PD, MSA, PAF, NDAN, or DBH Deficiency who

have been previously stabilized with droxidopa therapy for symptoms of orthostatic hypotension.

• Lawrence Wechsler is the Director of the University of Pittsburgh NINDS funded Stroke Trials Network as

a Regional Coordinating Center (RCC). The primary goals of the StrokeNet are to maintain a dynamic,

collaborative and sustainable administrative structure to rapidly implement stroke clinical trials, enroll

patients across a wide range of adult and pediatric populations to promote the career development of the next

generation of clinical-investigators in the neurosciences.

• Lawrence Wechsler is the P.I. for the Sanbio Stem Cell Trial study. The SanBio Stem Cell trial is a Double-

Blind, Controlled Phase 2b Study of the Efficacy of Modified Stem Cells (SB623) in Patients with Chronic

Motor Deficit from Ischemic Stroke.

• Dr. Zongqi Xia received funding from NINDS for an R01. Integrating Electronic Health Records and

Genomics to Predict Multiple Sclerosis Drug Response to gain insights into the factors that determine

treatment response and enable physicians to match an individual MS patients clinical and genomic profile

with uniquely tailored therapy to maximize effectiveness, delay disease progression and reduce overall costs.

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Educational Activities

The Adult Neurology Residency Training Program

The Neurology Residency Training Program continues to attract outstanding physicians from the United States and

around the world for state-of-the-art training in the diagnosis and treatment of diseases of the nervous system.

Twenty-eight residents train in the four-year program, which begins with one year of internal medicine residency

and then proceeds for three years of fulltime training in neurology. Resident trainees receive detailed instruction and

practical daily experience in the technique of the neurological examination, localization of abnormalities in the

nervous system, differential diagnosis, and neurological investigation and therapeutics. For a solid underpinning of

basic neuroscience for their clinical training, our residents are taught neuroanatomy, neurophysiology,

neurochemistry, neuroradiology, neuropathology, neuropharmacology as well as retrieval and analysis of current

medical information. There has been an increased emphasis on the fundamentals and application of evidence-based

neurology with special emphasis on the use of online data for decision-making assistance. Under the direction of

an outstanding faculty of attending neurologists, residents assume progressive oversight of patient care during the

course of their training. During the last two years of training, ample elective time allows each resident to develop

skills and expertise tailored to his or her particular interests, while the core curriculum assures a high degree of

competency in general neurology. The residents are given multiple opportunities to teach via formal lectures, small

group conferences and grand rounds presentations, activities which begin to prepare them for careers in academic

neurology, which most pursue. The vast majority of the graduating residents pursue fellowship training.

Neurology Boot Camp: Incoming PGY2 residents are greeted by an innovative and unique method of introducing

trainees to the rapidly growing field of neurology. This experience, termed “Neurology Boot Camp,” immerses our

junior trainees in a month-long fulltime intensive experience fashioned to provide a strong base of knowledge and

understanding upon which the remainder of their experience will build. This introductory course makes use of

extensive case studies, case simulations, an intensive Basic Neurologic Life Support lecture series, a series of

interactive neuroradiology-neuroanatomy correlation sessions, and hands-on rapid medical information retrieval.

Experience in initial training fosters the achievement of a high level of core clinical competency earlier in the course

of training, and lays an even stronger foundation of skills for ongoing lifelong self-education. The program continues

with a renewed emphasis on functional neuroanatomy, localization, and exercises in clinical neuroanatomy mainly

the neurological examination.

Introductory lectures are given in EEG, EMG, and neuroimaging and lectures are also provided about neurologic

emergencies, neurologic tactics.

Dr. John Doyle co-directs the Neurology Residency Program with Dr. Robert Kaniecki and Dr. Ajitesh Ojha is

Assistant Program Director.

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Advanced Neurological Fellowships

Advanced training fellowships in Clinical Neurophysiology, Stroke, Endovascular Neurology and Movement

Disorders are offered through the Department of Neurology. In July 2002, the Stroke fellowship here was one of

the first in the county to receive ACGME approval. Fellows enter these highly competitive positions after

completing a full neurology residency.

Clinical Neurophysiology fellowships emphasize electroencephalography, peripheral neuromuscular physiology,

epilepsy, and neuromuscular disease. Fellows select either an EEG-epilepsy or EMG-neuromuscular track, but have

broader exposure to clinical neurophysiology. There are two funded positions, but the program is accredited for up

to four fellows.

Stroke fellowships provide comprehensive training encompassing the whole spectrum of the rapidly evolving field

of vascular neuroscience. Stroke fellows gain extensive experience with clinical management of complex disorders,

advanced neuroimaging techniques, intravenous and endovascular reperfusion therapies, telestroke, secondary

stroke prevention strategies including endovascular and surgical options for large vessel stroke, advanced diagnostic

and therapeutic options for cardioembolic stroke and evidenced based medical management for stroke prevention.

In addition, fellows are expected to participate in clinical trials addressing all facets of stroke diagnosis and

management. Independent research projects leading to publication in peer review journals are strongly

encouraged. The Stroke fellowship has been expanded to include exposure to interventional and open

neurosurgical given the close integration between the stroke and interventional services. Three ACGME accredited

fellowship positions are offered yearly. Endovascular Neurology: The UPMC neuroendovascular center is one of the highest volume centers in the country.

Fellowship includes training in the whole gammut of neurointerventional procedures such as diagnostic

angiography, stroke intervention, extra and intracranial stenting, aneurysm coiling avm.a-v fistula embolization

and spinal diagnostic angiography and interventions. CAST accreditation is expected to be in place during

2015. Fellows are trained by an interventional team comprised by two vascular neurologists and two vascular

neurosurgeons. The UPMC neuroendovascular fellowship has a strong track record of training neurologists and is

multidisciplinary being fully integrated within neurology and neurosurgery. Considerable experience is obtained

from an extremely active acute stroke service and a busy vascular neurosurgery practice. One fellowship position

is offered yearly.

Movement Disorders Fellowship

Overview

The Movement Disorders Fellowship Program at the University of Pittsburgh brings together resources of the

University of Pittsburgh, Pittsburgh Institute of Neurodegenerative diseases (PIND) and the University of

Pittsburgh Medical Center (UPMC) to provide a unique educational environment with extensive resources

available for clinical and research training in the field of movement disorders. The fellowship program seeks

candidates committed to an academic career in the neurosciences with specialization in Movement disorders.

Consequently, this program emphasizes both clinical and research training in a 1 or 2-year training program.

All fellows will be thoroughly trained in clinical evaluation and management of Movement Disorders. In

addition to developing clinical expertise to become a Movement Disorder Specialist, each fellow will also

participate in one of three individualized research tracks: a Clinical research track, a basic science research track,

or a translational research track which combines elements of clinical and basic science research.

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The description that follows serves only as a guide, as each fellowship will be individualized based on the

applicants interests and goals.

Fellowship Goals and Objectives

1. To be prepared for a career in academic neurology as a movement disorders specialist.

2. To gain clinical expertise in the recognition and treatment of all Movement disorders including Parkinsonian

disorders, Huntington disease, Dystonia, tremor, Tourette Syndrome, chorea, athetosis, tardive

dyskinesia/medication-related movement disorders, ballism, myoclonus, tics, spasticity, rigidity, restless

legs syndrome, gait disorders, ataxia and other movement disorders.

3. To understand the pathophysiology (biochemical, pharmacologic, genetic and physiologic mechanisms) of

movement disorders

4. To learn how to employ pharmacologic, surgical, physiotherapeutic and other treatment approaches to

movement disorders. This includes learning techniques in botulinum toxin injections and programming for

deep brain stimulation.

5. To become familiar with counseling patients and families with movement disorders

6. To acquire skills in clinical, basic science or translational research essential to research methodology of

interest to the applicant. Examples include critical appraisal of relevant literature, clinical rating scales in

the assessment of movement disorders, grant and manuscript writing skills, the conduct of clinical trials,

study design, secondary data analysis or laboratory techniques for a particular project.

7. To develop and present results of clinical, basic science and/or translational research in movement disorders.

This may take the form of a peer-reviewed publication and/or presentation at a scientific meeting.

Fellowship activities

The above goals are accomplished by an experience organized around the following areas:

Clinical Activities

Each fellow will gain expertise in outpatient management of movement disorders under supervision of faculty.

Our faculty represents a diverse range of interests in movement disorders and is committed to teaching fellows.

In addition to outpatient clinics with a wide range of movement disorder patients, specific opportunities exist in

the following fellowship experiences:

a. Comprehensive Movement Disorders Clinic: Every two weeks, all faculty and fellows meet for

movement rounds, which is either a live patient discussion of an interesting case or video rounds. There

is also a clinic in which all movement faculty see patients and a physical therapist is on site to assist in

evaluating and treating movement disorders.

b. Huntington disease Clinic: Once a month, this multidisciplinary clinic serves individuals with

Huntington disease. This includes patient visits with a movement specialist, social worker and genetic

counselor.

c. Dystonia/Botulinum toxin Clinic: Every two weeks, patients with dystonia are evaluated and treated,

many with botulinum toxin injections.

d. Tourette Syndrome Clinic: Once a month, this multidisciplinary clinic at Children’s Hospital evaluates

pediatric movement disorders, primarily tic disorders. This includes an adult movement disorders

specialist, pediatric neurologist and a psychologist.

e. Deep Brain Stimulation: Our clinic is involved in pre-surgical evaluations and postoperative

programming and management of a large number of patients treated surgically with deep brain

stimulation. We work closely with neurosurgery and have bimonthly interdisciplinary meetings with

neurology, neurosurgery, and neurophysiology to discuss cases as well as clinical/scientific aspects of

DBS therapy.

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Research Activities

An individualized program for each fellow will be developed in consultation with faculty in one of three research

tracks:

Clinical research track: Clinical research may include a wide range of topics with any movement disorder

including epidemiology, observational studies, clinical trials, retrospective case reviews, phone surveys,

physiology or other areas of clinical research.

Basic Science research track: Basic science research opportunities exist within any of the wide variety of

laboratories associated with the PIND and the University of Pittsburgh neuroscience community, encompassing

work on in vitro/in vivo disease modeling, pathology, and neurophysiology as well as genetic, molecular,

biochemical, and behavioral aspects of neurodegenerative diseases and other movement disorders

Translational research track: This track emphasizes applying basic science concepts to clinical research.

Examples of translational research include investigations of biomarkers, genetic studies or pilot studies for novel

diagnostic or treatment interventions.

Fellowship Curriculum

Regardless of the track selected, the goal of the Fellowship program is two-fold: (1) To become an expert in

the clinical management of movement disorders, and (2) To successfully develop an area of research expertise.

Fellows are expected to complete at least one research project from conception to publication by the end of

fellowship (typically two years). Because clinical experience informs research activities, fellows will have an

initiation period of the first several months engaged in mostly outpatient movement disorders clinics

(approximately six half-days a week). The remainder of the time during this period is to be used to develop

plans for research. By the end of the initiation period, a project and mentor(s) should be identified, at which

point more time will be reserved for research for the remainder of the fellowship (clinic time may range from

2-5 half-days a week). The duration of the initiation period has an estimated range of 3-6 months. These

numbers are meant to serve only as a guideline to give applicants and idea of what to expect as research and

clinical time will vary based on individual interests, needs and goals.

Learning experiences There are a variety of learning experiences during the course of the Movement disorders fellowship. In addition

to mentorship and faculty supervision during outpatient movement disorder clinics, there are Movement disorder

rounds every two weeks. During these sessions, faculty or fellows present a patient or videos to review with

the faculty from the Movement Division, house staff and medical students. A Movement disorder fellow

organizes these sessions. There is also a movement disorders lecture series given by faculty. Fellows may also

wish to attend grand rounds and review our collection of videos of movement disorders. Each fellow will have

access to a video camera to document movement disorders seen in clinic and then review them with faculty so

that each new patient is discussed in detail. Research methodologies specific to the fellows project will be

reviewed, and a timeline for clinical and research activities will be established at the beginning of fellowship to

ensure goals are accomplished in a timely fashion. Fellows will receive feedback regularly on their progress,

and fellowship program activities will be flexible to cater to individual needs. It is expected that fellows will

attend at least one relevant scientific meeting per year and present their research project at such a venue and/or

in a peer-reviewed publication.

Resources

The University of Pittsburgh, PIND and UPMC provide a rich and unique academic environment for career

development in the neurosciences. The Movement Disorders division is comprised of six faculty, clinical staff

and research associates who specialize in clinical care of movement disorders and have a broad range of

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research interests spanning basic, translational and clinical research. The division also has a digitized movement

disorder video database as a learning and research tool. Additionally, the PIND movement disorder research registry is a rapidly expanding resource of patients who have expressed interest in participating in clinical

research, and have been consented to be contacted for research activities. PIND also has several basic science

opportunities for research and we have ongoing collaborations with the Departments of medicine, psychiatry

and epidemiology at the University of Pittsburgh. Fellows have access to all of these resources during their

Movement disorder fellowship at the University of Pittsburgh.

Headache Medicine - fellowship is a 1-year UCNS accredited fellowship which accepts one applicant each year.

Headache fellows are exposed to the spectrum of headache conditions with intense clinical training under the

supervision of 5 faculty members. Outpatient and inpatient management of headache is emphasized, with additional

training in botulinum toxin injections and pericranial nerve blockade provided. Opportunities exist for elective time

in neuro-otology, neuro-ophthalmology, pain, pediatrics, and head trauma/concussion subspecialties.

Epilepsy - Fellowship provides one year of balanced educational and clinical experience in diagnosing and treating

the most complex forms of epilepsy, including expertise in presurgical evaluation and treatment of the most

challenging cases, along with the use of VNS, RNS and diets. In short, the Program is focused on the training of

academic epileptologists and includes the amount of clinical research that may be escalated commensurate with the

candidates’ aspirations. Currently, the program is undergoing an ACGME accreditation and required structural

changes.

Neurology Medical Student Clerkship

Dr. Laurie Knepper is the director of the University of Pittsburgh School of Medicine Neurology Clerkship and

the Neurology fourth year electives. Sara Carter is the medical student coordinator and administrator. The

Clinical Neurology clerkship is a third-year core clerkship. Students are scheduled per preference in one of six

clinical sites: the inpatient ward service, the inpatient consults service, the VA medical center, Shadyside

Hospital, Children’s Hospital, and neurology outpatient clinics. Students who are on the inpatient service are

also scheduled one half day weekly in the outpatient clinic, as are students who are rotating at Children’s

Hospital.

Each Wednesday students attend a total of nine case-based didactic lectures given by neurology faculty and

residents. These include Neuroradiology, Peripheral Nerve Diseases, Stroke, Movement Disorders, Seizures,

Headache, Multiple Sclerosis, and an NBME subject examination review. Neurology residents have also put

together four neurologic emergency cases which they take turns presenting as one of the student didactics.

Students attend a pediatric Neurology case conference via teleconference at Children’s Hospital at 1pm on

Tuesdays. Students perform an OSCE neurologic exam on a standardized patient at the end of their first week

as a formative exercise; they receive feedback on professionalism and accuracy/ completion of components.

They also attend a two-hour Neuropathology small group session which includes gross sections of brain and

review of neuropathology. Finally, the students take an evening of stroke night call until 11pm with the senior

resident. This enables the students to observe the patient sign-out process and the acute evaluation and

management of stroke patients.

The main educational emphasis of the clerkship is on being able to perform a complete and organized

neurologic examination by the end of their rotation. This is demonstrated by Dr. Knepper at orientation and the

OSCE neurologic exam is at the end of the first week. The students receive a hard copy of a syllabus, which is

also available online on the UPSOM Navigator System. This outlines the clerkship goals and

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objectives and how these are assessed. It also includes information about required forms and conferences, as

well as a list of suggested neurology texts and websites available either online or through the Scaife Health

Science Library. The neurology faculty have also put together a topical syllabus that contains a chapter for each

of the major neurologic disorders, which the students are encouraged to read as they progress through their

rotation. Each student is also loaned a copy of the book Neurology Blueprints.

The students are evaluated in several ways throughout the clerkship. A mid-clerkship evaluation of each student

is done by faculty or a resident and includes feedback as well as student self-reflection on their progress. Faculty

and residents also observe a complete patient history and physical exam for each student and fill out a form

that is signed by students and preceptors. This year there is a redesigned an EMR note review exercise. Each

student is now required to submit one note in the middle of the rotation, for which they receive formative

feedback, and a second note at the end, on which they are graded by one of five reviewers per a standardized

form. Students maintain an online learning log detailing patients they encounter, reviewed weekly by the course

director. The standard UPSOM clinical evaluation form is distributed through Medhub to all faculty, fellows

and residents with whom each student has worked and they submit them as they see fit. This evaluation

encompasses clinical knowledge, clinical skills, data reporting (oral and written, clinical reasoning, problem

solving, and differential diagnosis), professionalism and communication. The students are graded as follows:

clinical evaluations: 50%; the Neurology NBME exam: 25%; the observed patient history and exam: 10%;

EMR note review: 10%, Professionalism: 5%.

Dr. Knepper serves on the Curriculum, Retention, and Promotions Committees. She also leads the Department

of Neurology Medical Education Curriculum Committee.

Future Initiatives

Plans for the Department of Neurology include initiatives in the clinical, research, and teaching areas of our mission.

The department continues to expand with resultant improvement in clinical patient diagnosis and treatment activities.

The department continues to expand the MyUPMC access to include electronic registration and Care Anywhere to

afford patients autonomy and flexibility as active consumers of healthcare services. The department will continue

optimization of the Electronic Health Record (EHR) and review existing workflows to provide further efficiency

and streamlining as faculty and staff has become engaged participants of the upgrades. Additionally, we continue

to improve our self check-in kiosks and biometric screening device workflow to ensure efficiency and patient

satisfaction. The Department will utilize meaningful use data to report quality measures indicative of a fully

integrated EHR. Additionally, the department will work with Press Ganey to obtain and promote patient satisfaction

and best practices amongst all divisions as the department continues to expand to various locations within the

community.

With the expansion of the clinical research, residency, and fellowship programs, the department will focus on

streamlined patient throughput in clinical and administrative space to improve workflow and access to necessary

resources. The project will encompass all clinical and administrative staffing to provide timely and appropriate care

in patient friendly locations utilizing sufficient resources from clinic, multi-disciplines, and community resources.

Neurology’s research program continues to grow. Our researchers have specific plans to increase funding for basic,

clinical and translational research. The department has become one of the top nationwide for NIH research funding

and will strive to achieve more funding. The firm establishment and expansion of the clinical and translational

research programs in neurodegenerative diseases will receive increased attention and resources.

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The education of medical students, residents, and fellows continues to be a high priority. The department will

continue to improve and further develop the didactic programs for neurology residents under the direction of

residency director John Doyle, M.D. Fellowships will be organized and further developed in Vascular Neurology,

Movement Disorders, Neurobehavioral, and Neuromuscular Disease.

The administrative functions of the department are continuously reviewed and improvements made whenever

appropriate. The roles of our Division Chiefs have been expanded to support department administrative efforts. The

Executive Committee consists of the 10 Division Chiefs and the Vice Chairs for Research, Academic, Clinical

Affairs and VA Affairs. The Executive Committee has expanded with the addition of a Director of Inpatient Services

to lead a neurohospitalist division. The Executive Committee will continue to regularly review Department

operations and initiate improvements, modify policy, and advise expansion of clinical, research and teaching

programs as appropriate.

Clinical Activities

The 2015-2016 academic year saw continuing growth in the diagnosis and treatment services of the clinical practice

in the Department of Neurology (University of Pittsburgh Physicians–Neurology). The Department includes the

Divisions of Epilepsy, General Neurology, Headache, Movement Disorders, Neuromuscular Disorders,

Neuroimmunology/Multiple Sclerosis, Cognitive and Behavioral Neurology, and Vascular Neurology The

continued growth of the Alzheimer Disease Research Center in Neurology has expanded services in behavioral

neurology and memory disorders. Each division maintains a distinct mix of patient care, clinical research, and

teaching activities.

Neurology maintains a highly visible presence at several locations throughout Western Pennsylvania. The majority

of clinical activity takes place in the Oakland health system facilities, as well as meeting the needs in other

geographical areas. The Department has a state-of-the-art headache center located in Oakland. The Monroeville-

Oxford Drive, UPMC Shadyside, and UPMC Passavant offices offer general neurology and sleep appointments, as

well as Electromyograms (EMG) in an outpatient setting. UPMC Mercy also offers a full spectrum of outpatient

services including a fully accredited sonography laboratory. The Northshore Neurology practice encompasses a vast

array of outpatient services including general neurology, EEG, EMG, and acupuncture. The department continues

to provide services in St. Margaret’s, McKeesport, West Mifflin and Monaca which provides patient access to

general neurology, EMG and Botox therapy to patients located in these communities. Additionally, the department

also expanded services to Seneca which provides general neurology services as well as telemed patient services for

stroke, movement disorders, and MS.

Faculty members continue to be very active in community programs relating to their subspecialties, such as the MS

Society; National Parkinson’s Foundation; Pittsburgh Parkinson’s Foundation; the ALS Society; the National

Headache Society; Epilepsy Foundation of America; Muscular Dystrophy Association; Myasthenia Gravis

Association; Huntington’s Disease Society of America; and the Alzheimer’s Association. This includes serving on

community or professional advisory boards, and national boards of directors.

Financially, the Neurology clinical practice continues to maintain strong controls over expenditures and consistent

efforts at revenue enhancement including further expansion of clinical practice locations. Clinic operations and

staffing patterns are continuously monitored to ensure optimum return on financial investments. The growing

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presence of physician extenders and multi-disciplinary clinics provides a multitude of services and ensures timely

handling of all areas of care thus increasing efficiency and patient satisfaction. Faculty members are encouraged to optimize their clinic time and to fully and efficiently utilize the time they spend in the clinic. With the optimization

of electronic medical records, faculty is afforded the ability to access records on-demand in clinic and from remote

locations while improving patient care. The patient population continues to grow and clinic accessibility has

expanded to meet the demand. Neurology clinic accessibility has been significantly enhanced with new faculty,

appointment time management, and appropriate utilization of support staff.

Department Clinical Divisions

Division of Cognitive and Behavioral Neurology

Oscar Lopez, MD, Chief of the Cognitive and Behavioral Neurology Division directs the NIA-funded

Alzheimer’s Disease Research Center (ADRC) and is Co-Leader of the ADRC Clinical Core and conducts both

NIH and industry-sponsored experimental therapeutic studies of Alzheimer’s disease. Dr. Lopez’s main area

of concentration is Alzheimer’s disease research, and other related dementias. He led an NIH-funded study

examining predictors of Alzheimer’s disease in mild cognitive impairment (MCI) until April 2013. Dr. Lopez

is currently conducting studies, as principal investigator and co-investigator, of the factors that modulate the

transition from normal to mild cognitive impairment (MCI) and to dementia in relationship to cerebral amyloid

deposition. These studies examine how cardiovascular and cerebrovascular factors create a vulnerability state

for Alzheimer’s disease and neurodegeneration, and how they affect physiologically relevant compensatory

mechanisms in the brain using MRI, FDG-PET, and Pittsburgh Compound B (PiB) and tau ligand technologies.

Dr. Lopez has published, as first author or co-author, 18 peer-reviewed manuscripts between July 2016 and

June 2017. The Division of Cognitive and Behavioral Neurology has a paper published or accepted for

publication every week and a half.

Beth Snitz, PhD is a neuropsychologist with a clinical and research focus on mild cognitive impairment in

aging and early detection and prediction of Alzheimer’s disease. Her research interests also include cognitive

correlates of beta-amyloid, as measured by Pittsburgh Compound B (PiB) – PET and tau deposition, as

measured with [18F]AV1451 PET imaging. Dr. Snitz is involved 6 NIH-funded grants. She has published 9

peer-reviewed articles between July 2016 and June 2017.

She is leading the project entitled ‘Subjective cognitive complaints, longitudinal cognitive decline, and beta-

amyloid deposition in non-demented older adults.’ This research investigated subjective cognitive complaints

as a potential facet of early beta-amyloid-associated, sub-clinical neuronal dysfunction, along with subtle

cognitive deficits and gradual cognitive decline. She was awarded an R01 from the NIA for the project entitled

“Alzheimer Neuroimaging-biomarkers in pre-clinical cognitive decline from a population based study.

Dr. Snitz involved in multiple NIH-funded projects. 1) She is the leader of the Clinical Core of the NIA-funded

program project grant ‘Imaging Pathophysiology in Aging and neurodegeneration (PI: Klunk); 2) she is a co-

investigator on ‘Mild Cognitive Impairment: A prospective community study’ (PI: Ganguli), a population study

of predictors and outcomes of MCI in small-town Southwestern Pennsylvania. 3) She is the

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Clinical Core leader of Alzheimer’s Disease Research Center (PI: Lopez); 4) She is the clinical Core leader of

the Human Connectome Project (PI: Becker). She actively collaborates with colleagues Drs. Ganguli, Klunk,

and Lopez on epidemiologic and clinical studies of cognitive aging, MCI and PiB-PET imaging, including a

longitudinal study of normal aging and beta-amyloid deposition; and a study of cognitive correlates of early

striatal beta-amyloid deposition in early onset familial AD.

In addition to her clinical and research pursuits she is actively involved in Medical Student education at the

University where she is involved in clinical teaching, and mentoring medical students.

Epilepsy Division

During the 2016-2017 academic year, the Epilepsy Division staff included: Anto Bagić, MD, PhD, FACNS

(Professor of Neurology and Neurosurgery, the Division Chief, and Director of the Epilepsy Center, EMU, and

MEG Epilepsy Program), Arun Antony, MD (Assistant Professor Neurology; Director of Continues EEG Service),

Gena Ghearing, MD (Assistant Professor of Neurology; Director, EEG Laboratory and Clinical Neurophysiology

Fellowship; until 12/31/2016), Rick Hendrickson, PhD (Assistant Professor of Neurology, Neuropsychologist;

until 05/01/2017), Jullie W. Pan, MD, PhD (Professor of Neurology), Alexandra Urban, MD (Assistant Professor

of Neurology, Medical Director, Epilepsy Surgery Program; Director of EEG Laboratory and Clinical

Neurophysiology Fellowships since 01/01/2017), and Naoir Zaher, MD (Assistant Professor of Neurology). Maria

Baldwin, MD (Assistant Professor Neurology) and Anne C. Van Cott, MD (Associate Professor of Neurology,

Neurology Service/VA Pittsburgh Healthcare System) are academic members of the Epilepsy Division. Additional

clinical care has been provided by Jill Bischoff, CRNP. Our staff specializes in the comprehensive evaluation and

treatment of patients with all forms of epilepsy including those that are very difficult to diagnose or manage.

In addition to the Department of Neurology, clinical and research activities of the Epilepsy Division take place in

the context of the University of Pittsburgh Comprehensive Epilepsy Center (UPCEC) which is a Level 4

National Association of Epilepsy Centers (NAEC) Epilepsy Center that provides state-of-the-art diagnostic and

treatment services to adults and children with epileptic seizures and related paroxysmal disorders. It is a joint

program combining the resources of the University of Pittsburgh School of Medicine, the University of Pittsburgh

Medical Center (UPMC), Presbyterian University Hospital (PUH) and Children's Hospital of Pittsburgh (CHP).

Established in 1986, among one of the first dozen specialized epilepsy centers in the Country- over the last 30 years

(1986-2016), it has been providing regional referral and consultation services to Pennsylvania, Ohio, West Virginia,

and beyond.

Some Clinical Highlights: Our center remained at the forefront of medical technology, with the most modern digital

video-EEG equipment, latest imaging capabilities (PET, SPECT, MRI, fMRI, and PET-MRI), including a state-of-

the-art magnetoencephalography (MEG) facility, and the EMU equipped with automatic remotely-controlled

SPECT injectors. We improved further by upgrading one more room with new equipment for invasive monitoring.

These advanced diagnostic capabilities, coupled with sustained and comprehensive efforts providing the optimal

care for the hardest-to-treat epilepsy patients with medically uncontrolled seizures, in concert with the Adult

Epilepsy Surgery Program, resulted in a continuation of the large surgical volume and consistently filled the EMU,

continuation of implantation of the RNS Stimulators and adoption of laser ablation in our routine treatment options.

Thus, we remain among one of the leading Epilepsy Centers in the Country.

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Expanding Diagnostic Options for Surgical Candidates: Stereo EEG (SEEG) evaluation is a novel technique

adopted by UPMC in 2013 for localization of seizure onset and analysis of seizure spread. Although a widely-used

method in Europe, only the most capable centers in the United States have the capability of performing this

complicated procedure. SEEG evaluation samples the brain in a 3D space by placing electrodes stereotactically in

the desired locations even when the regions are deep inside the brain. In addition to sampling of the structures deep

inside the brain (i.e. insula, interhemispheric region, orbitofrontal region, operculum, hippocampus) SEEG

evaluation is indicated in patients with multiple seizure foci in both cerebral hemispheres, patients with a network

involvement and those who failed a previous evaluation using subdural grids. After electrode placement in the brain,

cutting edge software allows co-registration of the electrode positions on to the patient’s MRI to pinpoint the location

of abnormal wave forms in all planes of intracranial space. Further analysis of the waveforms during and in between

seizures aims to determine the “epileptogenic zone”, which is the smallest region of the brain that should be resected

to render the patient seizure free. Electrical stimulation of the electrode contacts in the brain is performed to map

cortical functions and to induce seizures for analysis. SEEG evaluation avoids the need for a craniotomy, which is

necessary in a subdural grid evaluation, thereby decreasing pain while offering better aesthetic appeal. Over the last

year, the majority of our patients needing invasive monitoring underwent SEEG as oppose to subdural grid

placement.

Expanding Therapeutic Options for Patients with Pharmacoresistant Epilepsy: The UPMC UPCEC remains

among the top tier of the USA epilepsy centers that offer the full spectrum of all available and evidence-supported

treatment options for drug resistant epilepsy, including Responsive Neurostimulation (RNS) and newly adopted laser

ablation. However, the limiting factor, as it was emphasized in the 2012 IOM Report (“Epilepsy Across the

Spectrum: Promoting Health and Understanding”), is not the availability of treatment options, but the timely referral

for their appropriate consideration without unacceptable delays.

Leading the System-Wide Optimization of Clinical Care: In an attempt to optimize the patient care for epilepsy

patients system-wide, the Epilepsy Service Line was established through the Neurological Institute. The UPCEC

leadership is proposing a new UPMC System-wide Epilepsy Program and suggests the specifics of the organizational

concept and corresponding needs. The key strategic orientation is to improve an access to the specialized care as the

bottleneck of epilepsy care countrywide. While our internal logistics improved considerably over the last five years,

their further optimization is a part of the overall plan for the UPMC System. It is expected that this will lead not

only to standardization but also optimization of care in terms of timeliness, medication choices, utilization of

expertise and resources, and ultimately translate into better outcomes.

In summary, clinical facilities at the center and the expertise of the staff result in definitive diagnoses in patients

with seizures of uncertain origin and medication regimens for optimal seizure control and minimal side-effects.

Patients with medication-resistant seizures can be evaluated for all surgical treatment alternatives including the most

complex surgeries, a Vagal Nerve Stimulator (VNS), RNS implantation and laser ablation. Patients also have access

to neuropsychological evaluations, medication response monitoring, rehabilitation, psychosocial services, referrals

and the possibility of participating in promising clinical drug trials.

Research conducted at the UPCEC had contributed to the introduction of multiple new antiepileptic drugs over the

past decades. Currently, in addition to multiple smaller studies, the major ongoing multicenter trails include: The

ROSE (Radiosurgery vs Lobectomy for Temporal Lobe Epilepsy) Trail (NIH-funded, completed), MONEAD

(Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs) study (NIH-funded), the Established

Status Epilepticus Treatment Trial (ESETT), and “ASCEND: Vagus Nerve Stimulation Titration Protocol to

Improve Tolerance and Accelerate Adaptation” (aka the E-40 Study).

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New Line of Research at UPMC: Since joining the University of Pittsburgh April 2013, the laboratory of Jullie W.

Pan, MD, PhD has focused on studying and identifying the metabolic dysfunction that is commonly seen in

medically intractable epilepsy. As many of their projects are highly translational, they use and develop advanced

imaging methods including MR spectroscopic imaging (MRSI) to achieve this. The group has identified networks

of brain dysfunction in epilepsy and has found that outcomes of localization-related epilepsy (temporal and extra-temporal) patients are significantly related to concordance between MRSI abnormalities with surgical resection.

Currently, as a part of their NIH-supported project (R01 EB-011639), the group is collaborating with NYU (New

York University) to further develop and evaluate the role of MR spectroscopic imaging in surgical epilepsy. The

team remains very active in forging national and international collaborations.

General Neurology Division

Currently, physicians from the Division of General Neurology see outpatients at the Kaufmann Building in Oakland,

UPMC Monroeville, and UPMC Passavant. Members of the division also see inpatients at UPMC Presbyterian,

Magee Woman’s Hospital, and UPMC Passavant. The Division Chief is John Doyle, MD who is also director of

the residency program. Other members of the division are Dr. Angela Lu, Dr. Simin Khavandgar, and Dr. Kelly

Kay.

Dr. Doyle sees general neurology outpatients in the Neurology Division, Kaufmann Clinic where he supervises eight

neurology residents in neurology continuity clinic. Dr. Angela Lu sees out-patients at the Kaufmann Clinic and

provides EMG services at UPMC Passavant. She also provides EEG interpretation services at UPMC Presbyterian.

Dr. Kelly Kay conducts a general neurology clinic and electrodiagnostic (EMG) testing at the

UPMC Monroeville satellite center. Dr. Simin Khavandgar sees general neurology patients and patients with sleep

disorders at UPMC Monroeville, and performs EMG studies at that site.

The General Neurology Division is integral to the training of both medical students and neurology residents. Several

members work closely with medical students during required neurology rotations. Dr. Doyle directs the neurology

continuity clinics for neurology residents, and is assisted by Dr. Angela Lu. During resident training, the neurology

resident must conduct a half-day clinic each week, and follow the patients seen there for the remainder of the training

period. Extensive instruction in clinical neurology, the use of online information retrieval during patient encounters,

neuroimaging, and effective patient management and communication is provided. Resident responsibility

progressively increases during the three-year period of residency. The out-patient clinics prepare residents for

clinical practice at the completion of their training.

Headache Division

Robert Kaniecki MD, Laurie Knepper MD, Barbara Vogler MD, Josif Stakic MD, Claire Yanta MD

Kimberly McGonigle PA-C, Katie Marlin PA-C

Our group continues to provide outpatient clinical services at the Headache Center situated in central Oakland.

Annual clinical volumes at the Headache Center continue to expand to over 12,000 visits per year. In addition to

typical clinical assessments the clinicians provide emergency parenteral therapies, nerve blocks and trigger point

injections, and botulinum toxin administration to appropriate patients with severe or chronic headaches. In addition

to outpatient responsibilities, Drs. Vogler and Yanta spend time on the Neurology Consult service and Drs. Kaniecki

and Knepper on the Neurology Ward service at Presbyterian University Hospital; residents and medical students are

supervised on both services. Dr. Stakic and Dr. Yanta attend at Shadyside Hospital. Lectures

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on headache and pain are delivered by Dr. Kaniecki to the first, second and third-year medical students and to

residents and graduate students in Neurology, Psychiatry, Internal Medicine, Family Practice, Pharmacology, and

Pain Medicine. Drs. Knepper and Stakic also lecture to the medical students. All faculty members supervise resident

and medical student rotations though the Headache Center while all physicians assist in the fellowship training

program.

In 2012 Dr. Kaniecki was named Director of the Headache Fellowship program, and in 2013 Assistant Director of

the Neurology Residency program. Dr. Kaniecki serves as chairman of the Scientific Review Committee, as a

member of the residency selection, residency curriculum, and compensation committees, and the executive

committee for the Department of Neurology. Dr. Kaniecki remains on the editorial board and acts a co-editor of the

Abstracts and Citations section for the journal Headache. In 2012 the Headache Division’s fellowship program in

Headache Medicine was initially accredited by the United Council for Neurological Subspecialties, and in June 2014

received notice of 5-year accreditation status. In 2016 Dr. Kaniecki was again awarded the Excellence in Clinical

Teaching Award in the residency program.

In 2016 Dr. Knepper was named Director of the Neurology Clerkship. She also serves on the Pediatric Neurology

milestone committee, the Promotions committee, the Retention committee, and the Neurology Medical Student

Curriculum committee. She serves as Chair of imaging task force curriculum committee.

She also is a member of the Women in Neurology Core Group.

Dr. Stakic is participating in the Masters in Education program here at the University of Pittsburgh. In 2016 he was

part of a University of Pittsburgh team charged with the development of a neuroscience curriculum for the Republic

of Kazakhstan’s Nazarbayev University newly established School of Medicine

Dr. Yanta was named assistant Director of the Neurology Clerkship in 2016. She continues to expand her capacity

in this role.

Dr. Andrew Levin accepted a position in our fellowship program from the 2017-2018 academic year. He has also

accepted a subsequent faculty position to begin in July 2018.

Dr. Kaniecki continues to conduct clinical research and publish in the field of Headache, and supervises student and

resident research projects resulting in poster presentations at scientific meetings. Drs. Kaniecki, Vogler, Knepper,

Stakic, and Yanta have all received board certification in Headache Medicine from the United Council for

Neurological Subspecialties. The Headache Center is planning to continue the expansion of clinical and research

services and its educational programs for medical students, Neurology residents, and Headache fellows.

Movement Disorders Division

The Movement Disorders Division is directed by J. Timothy Greenamyre, M.D., Ph.D. and includes Drs. Sarah

Berman, Ed Burton, Franca Cambi, Houman Homayoun, Valerie Suski and Amber Van Laar. Additional

clinical services are provided by Jessica Kappel, PA-C. The Movement Disorders Division has three broad

objectives: (i) to provide subspecialty care in Parkinson’s disease and other movement disorders; (ii) provide

education in movement disorders for medical students, graduate students, residents and fellows; and (iii) carry out

research in basic and clinical aspects of movement disorders. The American Parkinson Disease Association (APDA)

has designated the Division as a Center for Advanced Research, one of only 9 such centers in the nation. The

Division currently provides subspecialty care to patients with movement disorders through the Comprehensive

Movement Disorders Clinic, with participation by faculty and staff from the Departments of Physical Medicine and

Rehabilitation, Otolaryngology and Neurological Surgery. Many individuals seen in the clinic also volunteer to

participate in clinical trials of new treatments and in studies supported by the NIH and the VA Healthcare

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System. Clinical programs have grown steadily over the last few years and include the continued expansion of deep

brain stimulation as a treatment for advanced Parkinson disease (in collaboration with the Department of

Neurological Surgery) and a Dystonia/Botulinum Toxin Clinic. The Huntington Disease Clinic continues to grow

and is a Huntington Study Group research site and has been designated by the Huntington’s Disease Society of

America as a Center of Excellence.

During the past year, the Movement Disorders faculty continued to provide bedside and didactic teaching to

undergraduates, medical students and residents. Once a month there is a clinical conference for faculty, residents,

fellows and students at which interesting or difficult-to-diagnose cases are presented. There is a regular lecture

series for residents, and the Movement Disorders lecture series for the first year medical students has been revised

and has received excellent evaluations.

As it expands, the Division continues to have a vigorous and well-funded research program that investigates both

clinical and basic aspects of movement disorders. Each of the faculty has been successful in obtaining extramural

funding for their projects. Several new collaborative projects have begun, which cross traditional boundaries of

scientific discipline and academic department.

Neurocritical Care Division

The Neurocritical Care (NCC) Division of the Department of Neurology was established in July 2012 in a

collaborative effort with the Department of Critical Care Medicine (CCM). The past year has seen further academic

development of our core faculty; growth in NCC related research activities, and expansion of the NCC Fellowship

with the addition of new training opportunities.

The clinical focus of NCC is on the 20 bed Neurovascular and 10 bed Neurotrauma ICU at UPMC Presbyterian

hospital. Unit based, disease specific patient management protocols have been developed to optimize the basic

foundation of clinical care. In addition, a number of unit based, multidisciplinary quality improvement projects with

other members of the NCC team (advanced practice providers, nurses, pharmacists and therapists) have been

completed. These projects included development of a nursing driven fever management algorithm, introduction of

pupillometry, and use of phenobarbital to manage alcohol withdrawal.

Faculty updates include Lori Shutter, MD being selected as a Hedwig van Ameringen Executive Leadership in

Academic Medicine (ELAM) Fellow by the University of Pittsburgh. This program is a year-long part-time

fellowship for women faculty that is dedicated to developing the professional and personal skills required to lead

and manage in today's complex health care environment, with special attention to the unique challenges facing

women in leadership positions. She continues to excel as an educator and was named for the 2nd year in a row as

CCM Faculty of the Year by the critical care fellows in 2016. Her research focus is the area of traumatic brain injury

and advanced monitoring in neurocritical care. Bradley Molyneaux, MD, PhD is an Assistant Professor,

Departments of Neurology, Critical Care Medicine and Neurosurgery. He assists with the fellowship program, is

introducing multiple new clinical management protocols, and establishing his research lab. His research interests

include mechanisms of injury and repair of the cerebral cortex. to identify new mechanisms of neuroprotection and

plasticity after injury. Sherry Chou, MD is an Associate Professor, Critical Care Medicine, Neurology and

eurosurgery. She serves as a clinical research mentor for residents and fellows, collaborates with Neurosurgery on

neuro-monitoring and biomarkers studies in subarachnoid hemorrhage, and is developing the Neurocritical Care

Research Biorepository. Ruchira Jha, MD is an Assistant Professor, Critical Care Medicine, Neurology and

Neurosurgery. She holds a University of Pittsburgh Clinical and Translational Science Institute KL2 career

development award, and collaborates with Neurosurgery and the Safar Center for Resuscitation on research

involving the SUR-1 receptor and brain edema after brain trauma.

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The educational mission of the division continues to expand. The residents are active members of the Neurovascular

ICU during their required rotation, and we have seen increased interest of the neurology residents in NCC

fellowships. The UPMC NCC fellowship has a 5 year accreditation by the United Council of Neurological

Subspecialties (UCNS) and now has 3 accredited tracks for training opportunities within the Multidisciplinary

Critical Care Training Program of the Department of Critical Care Medicine. The tracks consist of the traditional 2-

year training program, a 1 year track for physicians who have obtained critical care training through another medical

specialty, and a 1 year track for Neurosurgery residents who desire specialty training in NCC. Now in its fourth year,

the program has had two graduates, both of whom took academic positions as leaders in development of NCC

programs. Josh Keegan, MD will be starting his second year of fellowship in July 2016, and is following a career

development track in clinical leadership and administration. The 1st year incoming fellow as of July 2016 will be

Namir Khandker, MD, who completed his Neurology residency at Case Western.

Research activities for the Division of NCC focus on efforts to understand the pathophysiology of neurological

injury and clinical management of critically ill neurology patients. There are a number of ongoing clinical trials with

NCC faculty in leadership roles and additional projects are being considered.

In summary, the Division of Neurocritical Care continues to show successful growth in all aspects of the academic,

clinical, educational, and research missions.

Neuroimmunology/Multiple Sclerosis Division

The Neuroimmunology Division includes faculty Drs. Rock Heyman, Islam Zaydan, and Zongqi Xia. Division

physician assistants are Ryan Orie, Jennifer Bajek and Lauren Tankesley. This active division has a

comprehensive outpatient clinical program that has earned awards for its excellence. The MS program is designated

as a Comprehensive MS Care Center by the National MS Society, recognizing comprehensive clinical, research, and

educational programs. Clinical Supervisor Margie O’Leary, Speech Pathologist and Ryan Orie PA-C are board

certified in MS care. Kathleen Brandfass, MS, PT, Director of Neurologic Physical therapy, Center for

Rehabilitation Services is on site with our team. The program includes comprehensive care for all aspects of care

with close affiliations with many services at UPMC and throughout the region to meet the needs of people with MS

at all levels of disease severity. Clinical nurses include Margie O’Leary and Mary Skoff. The infusion center nurses

are Jennifer Victoria Young, Ann Caputo-Dunlap, and Melina Badanich. Many patients with other immunologic

conditions such as neuromyelitis optica (NMO), Sjogren's syndrome or sarcoidosis involving the central nervous

system are seen by this division in support of regional physicians. Ardrena Hill assist with clinical care, Jenna Pyle

provides administrative support for the division.

Division research continues and includes involvement in multi-center studies of oral or infusion therapies for MS

and NMO. Some of the agents used in current protocols are daclizumab, Ibudilast, and ocrelizumab. Other research

projects regarding MS and gastrointestinal dysfunction, MS related ataxia measures, and studies of the genetics of

myelin disorders are underway. The research coordinator, Kerry Oddis, and assistant, Darlene Punjack, provide

organization and support for these trials. Sandra Alhaj manages our Registry for MS and Related Disorders, which

has been supported by the Ethel Vincent Charitable Trust. This registry aids in the recruitment for multiple different

studies. With the addition of Dr. Xia, translational research done in our division and at UPMC and the University of

Pittsburgh is expanding.

Educational programs by division staff are directed towards people with MS, caregivers, allied health professionals,

medical students, residents, and physicians. Medical students and neuroscience students are

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frequently present in the office with our professionals and student nurses off work with our infusion Center nurse

staff. Division personnel frequently lecture to the numerous support groups throughout the region and often

nationally. Recent presentations by divisional professional staff at the CMSC meeting encompassed many areas of

MS care. Division educational conferences occur every Thursday morning. The division also works with regional

health insurance organizations to better organize and access the evolving MS care landscape. We work closely with

the National Multiple Sclerosis Society to provide education and care.

Neuromuscular Diseases Division

The Neuromuscular Division is directed by David Lacomis, MD. Dr. Lacomis and division members, Paula

Clemens, MD, Araya Puwanant MD, and Sasa Zivkovic, MD provide care for neuromuscular patients including

those seen in the affiliated Muscular Dystrophy Association Clinic and MDA-ALS Center (UPMC-Presbyterian

campus). Dr. Clemens also treats patients at the Pittsburgh VA Medical Center in Oakland including a

multidisciplinary clinic for veterans with ALS. Drs. Puwanant and Zivkovic also treat patients at UPMC-Shadyside.

The division trains fellows in clinical neurophysiology and provides electrodiagnostic services (electromyography

and autonomic testing) at UPMC-Presbyterian (Lacomis, Zivkovic, and Puwanant) and UPMC-Shadyside (Zivkovic

and Puwanant). Dr. Puwanant also performs single fiber EMG at UPMC-Presbyterian. Dr. Lacomis performs needle

muscle biopsies and is in charge of the neuromuscular pathology services in the Neuropathology Division. Dr.

Clemens works with trainees through her research program and oversees the neurology residency training program

at the VA Pittsburgh Healthcare System as Neurology Division Chief there.

Dr. Clemens conducts an active research program that includes both basic and clinical studies. Basic research

projects include characterization of the molecular pathology of mouse models of muscle wasting in muscular

dystrophy, muscle injury, idiopathic inflammatory myopathy and nerve injuries, and several methods of modulation

of NF-B signaling pathways for amelioration of the skeletal muscle phenotype in these disorders and modulation

of the immunity. Dr. Clemens is the elected Medical Director of a multi-center academic trials group, the

Cooperative International Neuromuscular Research Group (CINRG) devoted to natural history studies and treatment

trials for Duchenne muscular dystrophy (DMD) and other forms of muscular dystrophy. She chairs 2 multi-center

studies for this group with ongoing funding from the Department of Defense and NIH and she participates as a co-

site PI with Dr. Hoda Abdel-Hamid for other CINRG studies. Dr. Clemens is the chair for a multi-center DMD

treatment trial for a new dissociative steroid that is funded in part by an NIH Small Business Innovations Research

grant as well as other sources. Furthermore, Dr. Clemens is the chair for a multi-center DMD treatment trial for exon

53 skipping therapy, sponsored by NS Pharma, Inc. Dr. Clemens is also contributing Pompe disease patient

information to the Lysosomal Storage Diseases registry at UPMC (Dr. David Finegold, PI) and as a member of the

Pompe Registry Board of Advisors for Sanofi/Genzyme. She is site PI for a recently initiated treatment trial for

adult-onset Pompe patients sponsored by Amicus, Inc. Dr. Clemens is co-director of the University of Pittsburgh

NeuroNEXT clinical study site (funded by NINDS). Dr. Clemens serves on the Data Safety Monitoring Board for a

study sponsored by Pfizer and 2 studies sponsored by the NIH. Dr. Clemens is a steering group member of a group

organized by the Centers for Disease Control to update the Care Considerations for DMD.

Another major area of research involves ALS including participation in multicenter studies of serial biomarkers as

well as DNA banking and gene discovery. Drs. Zivkovic are developing a transcranial magnetic stimulation program

for ALS and using this methodology as part of a multicenter study of mexiletine. Dr. Lacomis provides subjects and

tissues for induced skin pluripotent stem cell research (with Drs. Carlisle, Friedlander, and Donnelly) and also serves

as the Director of Clinical Research in the Live Like Lou Center for ALS Research in the

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University of Pittsburgh Brain Institute directed by Dr. Peter Strick, and he works in close collaboration with Dr.

Christopher Donnelly. The expanding Center is dedicated to all types of ALS research and Neurotechnology

development leading to improved quality of life for patients. An ongoing project is development of an internal

biofluid repository.

Dr. Lacomis is a member of the Adjudication Committee for a study of “Tocilizumab in the Treatment of Refractory

Polymyositis and Dermatomyositis”, directed by Chester Oddis, MD from Rheumatology, and he is also working

on a Scleroderma Myopathy project with Drs. Medsger and Domsic from that division. Last, Dr. Lacomis is a section

co-editor for “What’s in the Literature.” published in the Journal of Clinical Neuromuscular Disease and serves on

its editorial board.

Dr. Zivkovic served as a site-investigator for the International Study of Guillain-Barre syndrome outcomes (IGOS)

and is site-investigator for the study “Expanded Access Protocol for Patisiran” for treatment of transthyretin amyloid

neuropathy. He is a member of IGOS GBS Electrodiagnosis Expertise Group. He is also a member of Brighton

Collaboration working group on immunization-associated events, including vasculitis and vasculitic neuropathy. He

is also working with Dr Soman from Cardiology and Dr Sehgal from Hematology as a part of TTR-Amyloidosis

working group. Dr Zivkovic also serves on AANEM Quality Improvement Committee and AAN. Subspecialty

Quality Advisors Group.

Dr. Puwanant is the Principal Investigator of the study “Sub-regional Body Composition and Clinical Endpoint in

Myotonic Dystrophy”, funded by the Muscular Dystrophy Association (MDA). Dr. Puwanant is the Executive

Committee Member of the NINDS-funded Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)

at the University of Pittsburgh. She is a member of Medical Scientific Advisory Board of the Myasthenia Gravis

Foundation of America. Dr. Puwanant also serves as a reviewer for European Journal of Neurology, European

Neurology, and Journal of the Neurological Sciences.

Research activities for 2017-18 include continued participation in ongoing ALS studies. Drs. Clemens and Abdel-

Hamid continue with muscular dystrophy trials through participation in CINRG, a multi-site academic clinical trials

network. Dr. Clemens takes an active role in CINRG, as Medical Director and study chair for 4 multi-center

protocols. Drs. Zivkovic and Lacomis will be site investigators in a treatment trial of mexiletene for ALS with

monitoring of cortical excitability via transcranial magnetic stimulation (TMS) as well as other outcome measures.

Dr. Lacomis will be the site PI for a new biomarker and deep phenotyping study of ALS using TMS, threshold

tracking, motor unit number estimation, and biofluid collection. The study will assess lower motor neuron burden

and also cognitive function. Dr. Puwanant will be the PI of the new MDA-funded study for myotonic dystrophy.

The study will evaluate sub-regional body composition, measured by DXA estimates, as a novel imaging biomarkers

for disease progression in myotonic dystrophy and the enrollment process will start in the summer of 2017.

Neurooncology Program

The Adult Neurooncology Program is the major regional referral center for patients with central nervous system

tumors, cancer metastatic to the nervous system, and patients with neurologic complications of cancer. Frank

Lieberman, MD (Professor of Neurology, Neurosurgery, and Medical Oncology and Director of the Adult

Neurooncology Program) provides inpatient consultation care for inpatients at the UPMC Shadyside and

Presbyterian campuses. Dr. Jan Drappatz serves as Associate Director of the Adult Neurooncology Program and

is Associate Professor of Neurology and Medical Oncology. The Adult Neurooncology program is committed to

expanding access of brain tumor patients to promising phase I and II clinical trials of novel anticancer agents,

molecularly targeted drug therapies for malignant and low grade gliomas, and primary central nervous system

lymphoma. The faculty of the Neuro-oncology Program provides the neurologic neurooncology expertise for the

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Neuro-oncology Specialty Care Center within the UPMC Hillman Cancer Center on the Shadyside campus. The

SCC is comprised of neurology, neurosurgery, and radiation oncology faculty, all combining to provide coordinated

multispecialty care to patients with primary and metastatic brain, skull base, and spinal tumors. The Neuro-oncology

Program faculty also provide expert consultation and management of non-metastatic neurologic complications of

cancer, including management of seizure disorders, cancer related pain syndromes, neurologic side effects of

chemotherapy and radiation therapy, and paraneoplastic neurologic disorders. Neuro-oncology faculty members

administer chemotherapy for patients with primary brain tumors and oversee and care for patients participating in

clinical trials through the University of Pittsburgh Cancer Institute.

On June 30, 2017, Dr. Megan Mantica, after completing her neurology resident as one of the chief residents in the

Department of Neurology, will be the first neurooncology fellow in our newly approved UCNS Neurooncology

Fellowship program. Dr. Mantica will be participating in patient care both inpatient and outpatient as well as our

translational clinical trial program.

The neuro-oncology program participates in a number of varied studies:

• The translational brain clinical trials program focuses on molecularly targeted drug trials of novel agents for

malignant gliomas. With the reconfiguration of the national cancer clinical trial consortia, Dr. Lieberman has

maintained a leadership role in Adult Brain Tumor Consortium and the NRG Consortium and in the

Experimental Imaging and Biomarker committees of ECOG-ACRIN. Dr. Drappatz is a member of the CNS

Tumor Committee for the Alliance for Clinical Trials in Oncology consortium.

• Through our participation in the ABTC, the Neuro-oncology Program provides patients with access to clinical

trials focused on novel molecularly targeted drugs in phase1 development. The Alliance, ECOG, and NRG

Consortia will be focusing on phase 2 and 3 clinical trials. The range of options for patients therefore spans

novel drugs in early phase development to more mature therapeutics being compared to current standards in

terms of efficacy.

o Our current NCI sponsored clinical trials portfolio includes multicenter trials of molecularly

targeted drugs, novel viral vector based therapeutics, vaccine trials, and immune checkpoint

inhibitor trials. We are participating in an ongoing trial of molecularly targeted drugs for patients

with recurrent or progressive meningiomas with specific mutations.

• We also participate in industry sponsored clinical trials evaluating novel pharmaceuticals, viral vectors

targeting tumor vasculature, and were one of the major US sites for the phase III trial which demonstrated

the efficacy of tumor treating fields for patients with newly diagnosed GBM.

In collaboration with Ajay Naranjan and Dade Lunsford in the Department of Neurosurgery, the Neuro-oncology

Program are conducting an industry sponsored trial evaluating gamma knife radiosurgery combined with

bevacizumab treatment in patients with recurrent glioblastoma. This study is actively accruing patients. The Adult

Neuro-oncology Program is collaborating with other members of the Adult Brain Tumor Consortium to evaluate

novel MRI and PET imaging techniques in assessing treatment response to molecularly targeted therapies, including

the use of 7T MRI to monitor the effects of anti-angiogenic therapies on the vascular anatomy of malignant gliomas.

Dr. Hoby Hetherington, Professor of Radiology, is leading a project imaging tumor metabolites using 7T MRI. In

collaboration with Dr. James Mountz, Dr. Lieberman and colleagues are evaluating a novel PET tracer which

selectively identifies apoptotic cells as a potential tool for determining whether malignant gliomas are responding

to treatment before there is a change in tumor size:

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• Dr. Nduka Amankulor, Assistant Professor of Neurosurgery, is investigating the interactions between

different mutational profiles in glioblastomas and the immune response. Dr. Amankulor is developing models

for elucidating the mechanisms through which IDH1 mutations in human gliomas affect gliomagenesis and

provide targets for molecular therapy.

• In collaboration with Colin Champ, Assistant Professor of Radiation Oncology, we are planning a phase I

clinical trial to address safety and dose-finding for 2-deoxyglucose in conjunction with a restricted ketogenic

diet for patients with newly diagnosed GBM. This is the first step in evaluated this metabolic therapy in

patients with malignant gliomas.

• Dr. Lieberman is currently serving as a member of the Biomarker Committee of the ECOG-ACRIN

consortium, which is tasked with developing the clinical trial infrastructure to evaluate advanced quantitative

imaging technologies to the evaluation of tumor treatment response. From 2012-2013, Dr. Lieberman chaired

the Clinical Trial Design Working Group of the Quantitative Imaging Network, following a year as co-chair

with Brenda Kurland, now a faculty member in the Department of Biostatistics in UPGSPH.

• With the recruitment of Dr. Gary Kohenbash, we are expanding an active immunotherapy clinical trials

program for high and low grade gliomas. Our institution conducted the first vaccine trials for low grade

gliomas. We are participating in the ABTC 16-024 study evaluating anti-LAG3 or CD137 (urelumab) alone

and in combination with nivulomab for patients with recurrent GBM. This is one of the first trials to combine

different classes of immune checkpoint inhibitors for treatment of GBM.

• With the recruitment of Dr. Sameer Agnahotri, we are establishing a laboratory program employing

molecularly engineered animal models of malignant brain tumors to explore the molecular pathways required

for malignant behavior. Dr. Agnahotri is also using these animal models to evaluate potential molecularly

targeted therapeutic drugs to optimize the choice of candidate drugs for human clinical trials.

• Drs. Jonathan Engh and Nduka Amankulor, director and co-director of the neurooncologic neurosurgery

division in the Department of Neurosurgery are collaborating in an UPMC Cancer Center collaboration to

establish tumors, derived from patient tumor tissue removed during surgery, in mice. This project will also

provide test systems for evaluating novel therapeutic agents and also have the potential to personalize

therapeutic testing by matching potential therapeutic agents to a specific patient’s tumor model.

• In collaboration with Dr. Lieberman, Marina Nikoforova and Ronald Hamilton in the Department of

Pathology are using micro-dissection based genetic analysis of brain tumor specimens removed at surgery to

better characterize molecular subgroups of glioblastoma, oligodendroglioma, anaplastic astrocyoma, and low

grade astrocytoma’s with different prognosis and response to therapy. Dr. Nikoforova is applying genome

wide SNIP analysis to paraffin embedded specimens. The molecular neuropathology program at UPMC is

one of the few centers in the world with CLIA certified deep sequencing technology and the neuro-oncology

program is currently participating in the development of a genetic profiling data base in which the genetic

profiling information obtained during clinical diagnostic testing can be used to provide patients with specific

tumor genetic profiles access to clinical trials with molecularly targeted agents aimed at the relevant genetic

abnormalities.

• The development of more effective therapies for patients with skull base and spinal tumors continues to be a

major focus of the Adult Neuro-oncology Program. In collaboration with Neurosurgery faculty Jonathan

Engh, Paul Gardner, and head and neck surgeon Carl Snyderman, Drs. Lieberman and Drappatz and Hussein

Tawbi (Division of Hematology/Oncology) care for patients with complex skull base meningioma’s, and

skull base and spinal chordomas.

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• In collaboration with Paula Sherwood (School of Nursing) the neurooncology program is participating in

studies of caregiver stress in families of brain tumor patients.

• The adult neurooncology faculty collaborate with neuropsychologist Dr. Robert Ferguson, newly recruited

to the Behavioral Oncology Program, in the evaluation of patients with cognitive problems associated with

cancer therapy. Dr. Ferguson is evaluating cognitive rehabilitation strategies for this group of patients

Quality Improvement:

o Neuro-Onc Task Force Initiative: development of hospital system wide multidisciplinary care guidelines to

optimize care of high-grade glioma patients.

Clinical Operations:

o Implementation of the Glio-Pilot project, a clinical pathway for neuro-oncology patients utilizing patient

navigators to improve patient experience and optimize utilization of support services

The Adult Neuro-oncology Program also provides training in neurooncology for neurology residents, neurosurgery

residents, hematology/oncology fellows, and medical students. Residents and fellows attend the neurooncology

clinics at the Hillman Center as well as participate in the neurooncology inpatient consultation service at UPMC

Shadyside. Dr. Lieberman directs a weekly multidisciplinary Neurooncology tumor board which guides the

treatment of complex cases throughout the UPMC Cancer Center network.

The neurooncology program faculty is also involved in continuing medical education at the national level. Dr.

Lieberman serves on the exam committee of the UCNS for neurooncology. This year, Drs. Drappatz and Lieberman

prepared the Neurooncology coursework for the Oakstone Board Review Course in Hematology and Oncology, in

which Hematology Oncology Division faculty are the featured faculty.

Teleneurology (Telemedicine)

Under the direction of Dr. Wechsler, the Department of Neurology began using telemedicine technology in 2008 for

the treatment of stroke patients within the UPMC system. Since that time, the stroke telemedicine network has

expanded to include more than 23 facilities both within and without the UPMC hospital system, and in 2015 has

begun preparations for a stroke telemedicine connection with hospitals in China. In addition, 2014 and 2015 saw

the expansion of this system to include inpatient general neurologic consultations in 2 hospitals.

Our department has been expanding its teleneurology relationships into the outpatient environment. We have

established telestroke clinics whereby Drs. Jovin and Jadhav provide outpatient consultations for potential

neurointerventional cases. In addition, Dr. Valerie Suski, from the Movement Disorders division, and Dr. Islam

Zaydan, from the Neuroimmunology/MS division, provide telemedicine outpatient consultation clinics in their

respective specialties.

Vascular Neurology

The Division is synonymous with the UPMC Stroke Institute and its activities are described under the Stroke Institute

activities.

Women’s Neurology

The Division of Women’s Neurology is directed by Janet Waters, MD, MBA. It is the newest division in the

Department of Neurology and was established in July 2011. This unique interdisciplinary program bridges

neurology with obstetrics, gynecology, obstetrical anesthesia, gynecological oncology, and women’s medicine, and

focuses on gender differences in medical evaluation, diagnosis, and implementation of treatment and care. Its

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specialists consider how hormonal and reproductive changes throughout a woman’s lifespan, including pregnancy

and menopause, as well as the use of oral contraceptives and assisted reproduction, impact neurological health and

disease. In 2015, a number of subspecialists joined the Division of Women’s Neurology while continuing to practice

within the division of their subspecialty. The following physicians have been welcomed into the Division of

Women’s Neurology; Dr. Araya Puwanant, MD of Neuromuscular Disease, Dr. Islam Zayden, MD of Neuro-

Ophthamology and Neuroimmunology, Dr. Robert Kaniecki, MD of the Headache Center, Dr. Valerie Suski, DO,

of Movement Disorders, Dr. Anto Bagic, MD and Dr. Alexandra Urban, MD of the Division of Epilepsy, and Dr.

Tudor Jovin, MD and Dr. Matthew Starr, MD of the Stroke Institute. There are three areas of emphasis: clinical

care, development of research, and patient and physician education. The division offers a clinical program where patients can see physicians specializing in clinical evaluation of the female neurological patient. The Obstetrical

Neurology Clinic offers Neurology services to women with neurologic disease during pregnancy and the post-

partum period and is the only program of its kind in Pennsylvania. Similar services are provided to inpatients on the

obstetrical service at Magee Women’s Hospital. This year, an Epilepsy Monitoring Room was established in the

Obstetrical ICU. Pregnant women with seizure disorders who are admitted to this unit can undergo continuous EEG

and video monitoring while under the close care of the obstetrical team. Inpatient neurologic consultation is also

provided to patients with breast and gynecological cancer with central and peripheral nervous system involvement.

A unique aspect to the division is the clinical and research collaboration with physicians at Magee Women’s Hospital

and the neuro-obstetrical concentration. With over 10,000 deliveries a year, Magee is one of the largest obstetrical

hospitals in the country and houses the extensive Magee Obstetric Medical and Infant (MOMI) research database

with information on more than 100,000 deliveries since 1995. These resources are unlike those anywhere else in

the country and can be used to answer clinical questions regarding women and neurological illness.

In 2016, a study was initiated using the Magee database to determine whether pregnant women with Arnold Chiari

One malformation may safely undergo vaginal delivery.

Due to persistent collaborative efforts through the Women’s Neurology Division, the UPMC became a part of the

two cardinal NIH-funded multicenter observational studies: 1. Women with Epilepsy: Pregnancy Outcomes and

Deliveries (WEPOD that is focused at examining the patterns of fertility among women with epilepsy (WWE)

compared to an age matched group of women without epilepsy (WWoE), and 2. Maternal Outcomes and

Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) that aims to establish the relationship between

antiepileptic drug (AED) exposure and outcomes in the mother and child as well as describe and explain the

variability in AED exposure and response.

Dr. Janet Waters was invited to speak at the American Academy of Neurology Meeting in April of 2016 on the topic

of Neurologic Issues in Pregnancy. She was also a primary editor of the recently published textbook, Neurologic Illness in Pregnancy, Principles and Practice.

In October of 2016, the Division of Women’s Neurology at UPMC will join forces with the Division of Women’s

Neurology at Harvard University to establish the first annual Obstetrical Neurology Conference. Course Directors

will be Janet Waters, MD, MBA and Angela O’Neal, MD, Division Chief of Neurology at the Brigham and

Women’s Hospital in Boston. This will be a multidisciplinary presentation to Neurologists, Obstetricians and Family

Practitioners that will include topics where the fields of Neurology and Obstetrics intersect. Speakers from both

institutions have accepted invitations to present and include members of the Departments of Neurology,

Neurosurgery, Obstetrical Anesthesia, and the Magee Women’s Institute.

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Department Institutes and National Center Affiliations

Alzheimer Disease Research Center (Director: Oscar Lopez)

The ADRC at the University of Pittsburgh, currently directed by Oscar Lopez, MD, was

established in 1985 by a grant from the National Institute on Aging (NIA) and has been

successfully renewed through 2020. The center initially focused on behavioral,

neuropsychological and neuropsychiatric changes over the course of the disease and has

evolved into a broadly based, full-service dementia research center, fulfilling its missions to

conduct clinical, basic, and translational research; provide excellent patient care and follow-up, and educate students,

residents, fellows, faculty, community physicians, and the lay community. Areas of research specialization include

neuroimaging and new neuroimaging modalities, neuropsychiatric symptoms and manifestations in Alzheimer’s

disease and other dementias, neuropathology, genetics, examination of factors that can alter the clinical course of

the disease, and the overlap of Alzheimer’s disease with other neurodegenerative disorders. A wide range of basic

and clinical research studies within the University community are supported by the patient registry, data, biological

materials, or expert consultation from the ADRC. The ADRC has one of the richest databases in the country for the

study of dementia. The ADRC cohort comprises of more than 5,000 patients and the brain bank has more than 650

brains.

The ADRC continues with multiple active research projects and scientific collaborations. During 2016, it has

provided clinical, radiological, genetic, and blood/plasma information to 51 federal- industry-, and foundation-based

grants, and to 28 different principal investigators. In addition, it has conducted 27 national, 12 international, and 11

local collaborative projects. We participate in several national consortia including the Alzheimer’s Disease

Cooperative Study (ADCS), Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Alzheimer’s Disease

Genetics Initiative (ADGI), and the National Alzheimer’s Collaborative Center (NACC) and the Dominantly

Inherited Alzheimer Network (DIAN). It has participated of 11 industry-based trials and projects, and supports two

research studies on African Americans: The influence of African dancing on neurocognitive decline and Novel

multiplexing proteonomics to study the periphery in AD.

Current research studies funded by the ADRC include:

• The identification of amyloid pathology more than 15 years prior to the onset of symptoms in early onset AD

• The examination of the factors that may promote or delay the progression of mild cognitive impairment to

very early AD

• The examination of aging effects on microglia and their role in the early pathology of AD

• Learning new fact knowledge through a basal ganglia reinforcement-learning system

• The exploration of cerebrovascular dynamics in the presence of cerebral amyloid.

• The standardization of synaptic density ligands.

• Head-to-head studies with two tau protein ligands.

• The analysis of synapse loss in AD using a novel Beta Amyloid peptide sensor.

• The genetics of behavioral symptoms in Alzheimer’s disease.

• The standardization of tau ligands for the diagnosis of neurodegenerative disorders.

• The psychiatric impact of disclosing an abnormal amyloid scan to individuals with MCI.

The clinical research component of the ADRC includes an evaluation and treatment program for individuals

experiencing memory impairment. Accurate diagnoses are established through an interdisciplinary approach with

evaluations in neurology, psychiatry, neuropsychology, medicine and social work. After diagnosis, eligible subjects

are followed longitudinally and participate in additional ADRC research studies. Currently, cutting-edge

neuroimaging studies and several experimental therapeutic trials are ongoing in Alzheimer’s disease and related

dementias.

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The PITT ADRC has been taken the necessary steps to ensure robust and unbiased results following strict scientific

methodology since its inception in 1985. Our research plan ensures that each core and project generates high quality,

reproducible, diagnostic evaluations, neuropsychological, and behavioral assessments to ensure robust and unbiased

results when our subjects are included in local, national, and international studies. For example, each participant in

our center is independently examined by a neurologist and a psychiatrist. After the initial examination, the final

diagnosis is reached at a consensus conference where all the neurologists, psychiatrists, neuropsychologists, and

clinicians discussed the clinical, laboratory, and neuroimaging features of each study participant. Because of this

carefully designed process, our diagnostic accuracy has been uniformly high, historically over 93% for AD

diagnosis.

American Parkinson Disease Association Center for Advanced Research

The University of Pittsburgh School of Medicine was designated an American Parkinson

Disease Association Center for Advanced Research in 2006. The APDA is the nation’s largest

grassroots Parkinson’s organization and has been providing patient and caregiver support, free

educational materials and scientific research support for 45 years. As an

Advanced Center, Pitt is part of a network of nine APDA centers at major universities and

healthcare centers across the country. Dr. Tim Greenamyre, the Love Family Professor and Vice-Chair of Neurology,

Chief of the Movement Disorders Division, and Director of the Pittsburgh Institute for Neurodegenerative Diseases,

directs the Pitt APDA Center for Advanced Research.

MDA-ALS Center; Live Like Lou Center for ALS Research

The University of Pittsburgh Center for ALS Research was designated by

Dr. Arthur Levine in 2006 with Robert Bowser, PhD (Pathology) as the

founding director and David Lacomis, MD (Neurology) as the founding

medical director. In 2011 following Dr. Bowser’s departure, Dr. Lacomis

assumed the leadership role in collaboration with colleagues in Neurosurgery (Dr. Robert

Friedlander), Neurology and Neuropathology (Julia Kofler, MD). In 2015, the Center was

incorporated in the newly formed Live Like Lou Center for ALS Research in the University

of Pittsburgh Brain Institute directed by Dr. Peter Strick. Dr. Lacomis serves as the Director

of Clinical Research, and the clinical arm extends to the MDA-ALS Center and

multidisciplinary clinic. The Center recruited a leading ALS researcher (Christopher Donnelly) and we are working

together on developing an institutional biofluid and tissue repository and expanding pluripotent skin stem cell

studies. Long-term goals are to implement clinical trials, spark innovation, and improve quality of life via

neurotechnology. Other ongoing collaborative projects include identification of cerebrospinal fluid and serum

biomarkers and DNA banking. The pluripotent stem cell study will allow examination of human motor neurons and

glia from patients and controls with ALS. In addition, Dr. Kofler maintains a large brain and spinal cord tissue bank

that will be utilized for future investigations. Patients seen in the MDA-ALS Center are able to participate in the

research noted above as well as in a clinical trial of mexiletene and an upcoming trial of a compound that may

ameliorate cramps. They also benefit from seeing multiple experts [including neurologists (Lacomis, Zivkovic,

Puwanant), a nurse practitioner (Rebecca Molczan, CRNP), physical and occupational therapist, dietician, social

worker, swallow and speech therapists, an MDA patient care representative, and an ALSA social worker] in a

multidisciplinary setting.

Geriatric Research Education and Clinical Center

The Geriatric Research Education and Clinical Center (GRECC) is funded by the

Department of Veterans Affairs and provides an integrated program of basic

biomedical, clinical and health services research, education of trainees and

practitioners, and clinical demonstration projects designed to advance knowledge

regarding care of the elderly, with an emphasis on stroke. The research component

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of the GRECC consists of three elements; (1) basic science, (2) health services research, and (3) rehabilitation

research. The basic science component is focused on the identification of novel genes whose products play a role in

regulating cell death after ischemia, and the development of strategies to reduce expression of neurotoxic response

genes or enhance expression of neuroprotective gene products in response to stroke. Health services research is

directed at addressing inappropriate prescribing and the overuse of medications in the elderly VA population

(geriatric polypharmacy). Rehabilitation research includes studies designed to determine the optimal parameters for

rehabilitation of aphasia resulting from stroke, to determine the degree that hearing impairment contributes to

cognitive dysfunction in the elderly, to develop a quality-of-life instrument for stroke survivors, develop innovative cardiac rehabilitation strategies and to address pain assessment and treatment in the elderly. The GRECC faculty

expended over $4.8M in direct costs from federally funded research during the federal Fiscal Year (FY) 2017 in

addition to the GRECC’s $1.9M VA core funding.

The education component of the GRECC is designed to ensure that existing knowledge in geriatrics and new research

findings are integrated into clinical practice and disseminated locally, regionally and nationally, and consists of two

elements; (1) postgraduate fellowship training in geriatrics for physicians, clinical rotations for internal medicine

residents and medical students, and clinical and didactic offerings for trainees in associated

health science fields, and (2) continuing medical education in geriatrics for physicians and other health service

practitioners. There were 141 GRECC trainees (including fellows, residents, medical students, and associated health

trainees) during FY2016 and approximately 929 attendees at GRECC CME activities.

There were fouractive GRECC clinical demonstration projects: 1) The Pittsburgh Intensive Residential Aphasia

Treatment and Educational program (PIRATE) is a novel residential outpatient aphasia rehabilitation program.

PIRATE provides a 21-day program of intensive aphasia treatment for veterans who reside at the John Heinz

Community Living Center in Aspinwal during treatment. 2) The Dementia Telemedicine Clinic that provides

comprehensive geriatric, neurological, psychiatric and social work services for Veterans with dementia including

telehealth services for patients at regional VA Medical Centers and Community Based Outpatient Clinics. These

clinical demonstration projects are intended to pilot novel ways of delivering care to elderly veterans. 3) A new

inpatient and outpatient cardiac rehabilitation (CR) program was developed that employees a large multi-disciplinary

team consisting of a cardiologist, geriatrician, nutritionist, psychologist, social worker, pulmonologist, nurse,

physical therapist, pharmacist, and specialists in sleep, pain management, smoking cessation, diabetes care, yoga,

and tai chi. The CR program stands out as a model of care that can accommodate patients with a range of medical

complexities as well as the logistic challenges associated with living far from the VA campus. 4) A new Geriatric

Polypharmacy E-consult program was developed that consists of a team of a geriatric pharmacist, geriatrician, and

project coordinator to provide e-consults to rural primary care providers at multiple Community Based Outpatient

Clinics (CBOCs) affiliated with the VAPHS for Veterans >65 and taking 10 or more regularly scheduled

prescriptions and non-prescription medications or who were taking any high risk medications.

Dr. Steven Graham, Professor and Vice chair of Neurology, is Director of the GRECC. Other Neurology faculty

members in the GRECC are Jun Chen, MD, Edward Burton MD, J. Timothy Greenamyre MD, Milos

Ikonomovic, MD, Guodong Cao, PhD, Xiaoming Hu, PhD, and Dandan Sun MD, PhD. Faculty from the

Department of Medicine, Divisions of Geriatric Medicine and General Internal Medicine, Neurological Surgery and

Communications Sciences Departments in the School of Rehabilitation Sciences are also members of the GRECC.

Pittsburgh Institute for Neurodegenerative Diseases

It is estimated that approximately one in four Americans will suffer from a

neurodegenerative disease, and virtually all of us will have a family member

with one of these conditions. Unfortunately, the underlying mechanisms of

neurodegeneration – and how they lead to disease – are not well understood.

The complexity of these diseases makes it impossible for any single

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scientist to find the cause or cure. Instead, it will require an integrated, collaborative, interdisciplinary approach –

involving interactive groups of scientists and clinicians – to make headway towards cures. This was the vision behind

the creation of the Pittsburgh Institute for Neurodegenerative Diseases (PIND).

Ultimately established at the University of Pittsburgh with generous one-time gifts from the Scaife Family

Foundation and the DSF Charitable Foundation, the PIND brings together in one place scientists and clinician-

scientists from diverse disciplines and perspectives – and several School of Medicine departments (Neurology,

Neurobiology, Pharmacology, Pathology & Structural Biology) – to collaborate on studies of neurodegenerative

disorders.

By virtue of both philosophy and architecture, the PIND is a center where there are no walls between individual

scientists, and where there are no barriers between basic scientific inquiry and translation of the latest findings into

new treatments. As such, the mission of the PIND is to transform cutting-edge science into novel therapies and

diagnostics that directly benefit individuals affected by neurodegenerative diseases, such as Parkinson’s disease,

Alzheimer’s disease, stroke, Huntington’s disease, multiple sclerosis (MS) and amyotrophic lateral sclerosis (Lou

Gehrig’s disease). The PIND’s research portfolio spans from basic laboratory studies of molecular and cellular

mechanisms of neurodegeneration all the way to clinical trials, including gene therapy in individuals with

Parkinson’s disease.

The mission of the PIND is bolstered by and integrated with clinical programs in the Department of Neurology,

including the Alzheimer’s Disease Research Center, the Comprehensive Movement Disorders Clinic, the UPMC

Stroke Institute, and the Muscular Dystrophy Association ALS Center. As such, we are actively engaged in clinical

research in neurodegenerative diseases, coordinating or participating in therapeutic trials in Parkinson’s disease,

Alzheimer’s disease, Huntington’s disease, stroke, MS and ALS, and we are a site for trials for both the Parkinson

Study Group and the Huntington Study Group. We have been designated by the American Parkinson Disease

Association as an Advanced Center for Parkinson Disease Research, the only one in the Commonwealth of

Pennsylvania. Additionally, we have been designated as a Center of Excellence by the Huntington’s Disease Society

of America.

Together, the PIND and its associated clinical programs are making sure and steady progress in addressing the

multiple challenges that neurodegenerative diseases present. The PIND is directed by J. Timothy Greenamyre, MD,

PhD.

The UPMC Stroke Institute

The UPMC Stroke Institute was the first stroke center in Western Pennsylvania to receive

The Joint Commission (TJC) designation as a Primary Stroke Center in 2004 and achieved

Comprehensive Stroke Center designation in 2013. The Stroke Institute continues to lead

as a major referral center, provider of high quality acute stroke management, and contributes

to the advancement in the field by participating in and leading enrollment to the most

pertinent clinical research trials for the field. The program focuses on quality patient care

using a multi-disciplinary team approach, flourishing clinical research program, and ongoing educational efforts for

health professionals and the community at large. Tudor Jovin, MD is the Director of the UPMC Stroke Institute.

The Stroke Institute is comprised of a cerebrovascular specific clinical service that provides in person coverage at

three hospitals (UPMC Presbyterian, UPMC Mercy, and UPMC Shadyside) resulting in over 2000 cerebrovascular

inpatients seen annually. In addition, an extensive telestroke network is in place providing remote stroke care at 28

hospital facilities throughout Western Pennsylvania and 1 site in Maryland. The outpatient Stroke clinic is staffed

by the stroke specialists, fellows, and nurse practitioners. Multiple medical and ancillary services are

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coordinated to provide the patient with a comprehensive approach to care and to promote the best outcome for the

patient. Ashutosh Jadhav serves as the Fellowship Director for the UPMC Stroke Institute, an ACGME

neurovascular fellowship, which accommodates 3 stroke fellows yearly. In addition, an interventional neurology

fellowship is fully integrated within the Stroke Institute. The fellows, residents, medical students and visiting

physicians from abroad enjoy a rich educational experience supported by resources and experts from other

disciplines interested in cerebrovascular disease and research.

Our faculty, Drs. Marcelo Rocha, Ashutosh Jadhav, Matt Starr, Cynthia Kenmuir, Tudor Jovin, Greg Walker, and

Lawrence Wechsler all neurologists with additional training in vascular neurology provide patient care and support

the fellows, residents and medical students during their medical training while actively involved in research either

through participation in multicenter clinical trials or through pursuit of internal research projects. Dr. Jadhav has

assumed leadership of stroke services at the UPMC Mercy and Shadyside campus’ and continues to staff the outpatient stroke office there. Dr. Tudor Jovin and Ashutosh Jadhav continue to expand the scope of the neuro-

interventional practice through the clinical services they provide in addition to research.

Throughout the year the Stroke Institute faculty and staff provide education for health professionals and the

community at large. An annual CME program, Stroke Update, is offered with the goal of providing physicians

(locally and nationally) current information on medical, interventional, and surgical management of the stroke

patient and updates on scientific advances in stroke and clinical trial activity. Additionally, the 10th annual all day

nursing conference with continuing education credits focusing on stroke was provided this year. The Institute

supports community programs and provides stroke education in many local settings. Both faculty and staff are

active on the local, state and national level providing education and participating in legislative activities to promote

stroke care. In addition, Stroke Institute faculty occupy leadership position as Principal Investigators or steering

committee members on several national and international trials pertaining to the field of acute stroke interventions

or recovery. The ongoing commitment to research by Stroke Institute faculty and fellows has materialized into over

15 stroke institute initiated study papers presented at major national or international meetings as well authorship in

over 20 peer-reviewed papers.

The unique UPMC hospital system allows the faculty and staff to work with all UPMC community-based hospitals,

improving the standards of stroke care. Telemedicine equipment for 24/7 stroke assessment has also been introduced

at UPMC Passavant/Passavant-Cranberry, UPMC St. Margaret, UPMC McKeesport, UPMC Magee, UPMC

Horizon, and UPMC Northwest and UPMC Bedford. In 2008, the Institute began to expand services to non-UPMC

affiliated hospitals and now provides telemedicine to regional hospitals such as Monongahela Valley Hospital,

Meritus Hospital in Hagerstown, MD, The Washington Hospital, Washington, PA, Jameson Hospital, and Heritage

Valley Medical Center – Beaver Valley campus, Uniontown Hospital, Armstrong County Memorial Hospital, Excela

health system with Westmoreland, Latrobe, and Frick hospitals, and Mon General Hospital in Morgantown West

Virginia. Since implementation of telemedicine within UPMC, over 3500 urgent stroke consults have been

conducted via telemedicine and over 1300 patients have been treated with IV thrombolytics. Depending on the site

capability, patients are either transferred to UPMC PUH for ongoing specialty stroke care or remain at the local

hospital for post thrombolytic stroke care.

Veterans Administration Neurology Service

The VA Neurology Service is a busy clinical in-patient consult and out-patient service

within the Medical Service Line at the VA Pittsburgh Healthcare System (VAPHS). It

provides out-patient and in-patient services to veterans with dementia, movement

disorders, headache, epilepsy, stroke, multiple sclerosis, neuromuscular disorders, neurological complications of

medical diseases and other neurological conditions. Physicians perform out-patient lumbar punctures for diagnosis

and botulinum toxin injections for the treatment of focal dystonias and there is a TOUCH program for natalizumab

infusions. We provide management of vagal nerve stimulators for the treatment of epilepsy and of deep brain

stimulators for the treatment of movement disorders.

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The clinical services of VAPHS include out-patient clinics at University Drive and Heinz VAMC facilities, in-

patient consultations at the University Drive and Heinz VAMC facilities and an EEG Laboratory at the University

Drive VAMC facility. The VAPHS is a referral center for VAMC facilities in Erie, Butler, and Altoona, PA and

Clarksburg, WV. We also provide electronic consults as part of an expanding telemedicine program at VAPHS. The

VAPHS EEG Laboratory is accredited by the American Board of Registration of Electroencephalographers and

Evoked Potential Technologists (ABRET).

The VA neurology service is fortunate to have a group of expert sub-specialists from the department of neurology

who work together as VA neurologists. Dr. Edward Burton directs our local movement disorders center, which

participates in the central VA Parkinson's Disease, Research, Education and Clinical Center (PADRECC). Dr.

Burton is a movement disorders specialist in the VA Neurology Service. He was joined in March 2014 by Dr.

Houman Homayoun and in July 2014 by Dr. Franca Cambi. Dr. Islam Zaydan joined the VA neurology service

during 2016 and now leads our clinical program in multiple sclerosis. Dr. Steven Graham is director of the Geriatrics

Research, Education and Clinical Center (GRECC), a VA institute focused on multi-disciplinary aspects of geriatrics

care and research. The VA neurology division participates in the education component of the GRECC as a clinical

training site for geriatric psychiatry fellows throughout the year. We also serve as a training site for the geriatrics

fellowship programs at UPMC and St. Margaret’s Hospitals. Dr. Anne Van Cott directs the VAPHS epilepsy services

and participates in the VA Epilepsy Centers of Excellence. She was joined in July 2015 by epilepsy specialist, Dr.

Maria Baldwin. In addition to out-patient clinical care and EEG interpretation, Dr. Baldwin is focusing on providing

neurology telehealth care through video-facilitated remote access visits and electronic consults. She will also be

providing an ambulatory EEG service. Dr. Paula Clemens leads a multi-disciplinary clinic for ALS patients.

The VA Neurology Service is a principal training site for our neurology residency program. On a rotating basis, two

residents are stationed at the VA to provide in-patient and out-patient care on an academic teaching service attended

by one of our attending neurologists. A third resident position is filled by a senior resident doing an out-patient clinic

rotation. The residents also benefit from the contributions to the didactic training program provided by VA

physicians, especially including instruction in EEG reading by Dr. Anne Van Cott. The VA neurology service further

contributes to the educational mission of the neurology department by serving as a clinical rotation site for medical

students in their third year of training and for acting interns in their fourth year of training. Dr. Van Cott directs the

VA clinical rotation site for medical students on their neurology rotation.

The majority of the neurologists on the VA service are engaged in clinical and basic research in addition to their

clinical and educational endeavors. Several VA neurologists held VA research grants during the year as described

in their individual faculty descriptions.

The VA Neurology Faculty for 2016-2017 was comprised of Dr. Paula Clemens, Chief of Service; and Drs. Maria

Baldwin, Ed Burton, Franca Cambi, Kathy Gardner, Steven Graham, Houman Homayoun, Eric Ogren, Anne Van

Cott and Islam Zaydan.

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32

Research and Scholarly Activities

Cognitive and Behavioral Neurology Division

Oscar Lopez, MD

Professor of Neurology

Chief, Cognitive and Behavioral Neurology

Dr Lopez continues actively involved in research. He is the Director of the University of

Pittsburgh Alzheimer’s Disease Research Center (ADRC); the ADRC was recently funded for

the cycle 2016-2020. In addition, he is the principal investigator of 4 NIH-funded grants, and he

is co-investigator in 7 NIH- and 1 DOD-funded projects.

Dr. Lopez is currently conducting studies, as principal investigator and co-investigator, of the

factors that modulate the transition from normal to mild cognitive impairment (MCI) and to dementia in relationship

to cerebral amyloid deposition. These studies examine how Dr Lopez continues actively involved in research. He

is the Director of the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC); the ADRC was

recently funded for the cycle 2016-2020. In addition, he is the principal investigator of 4 NIH-funded grants,

and he is co-investigator in 8 NIH- and 1 DOD-funded projects.

Dr. Lopez is currently conducting studies, as principal investigator and co-investigator, of the factors that

modulate the transition from normal to mild cognitive impairment (MCI) and to dementia in relationship to

cerebral amyloid deposition. These studies examine how cardiovascular and cerebrovascular factors create a

vulnerability state for AD and neurodegeneration, and how they affect physiologically relevant compensatory

mechanisms in the brain using MRI, FDG-PET, and Pittsburgh Compound B (PiB) and tau ligand technologies.

In collaboration with Dr. Janssen from Harvard University, he is examining the overall function of HDL,

specifically apoAI, ApoJ, and apoE concentrations of HDL with and without apoCIII, in relationship to amyloid

deposition in the brain, and incident dementia. We found that these proteins, rather than being broadly

distributed across the entire population of HDL, define subpopulations of HDL that each comprise a minority

of HDL particles. The central hypothesis of the study is that apolipoproteins form new discoverable HDL

subspecies that contain more value for risk prediction than the present homogenous measures of HDL levels.

In collaboration with Dr Sekikawa from University of Pittsburgh, he is examining the presence of amyloid

deposition in the brain of a Japanese population in the city of Osaka, Japan. This study will examine whether

a population with a different lifestyle from Western populations has different patterns of amyloid deposition.

The findings in the Japanese cohort will be compared to The Mayo Clinic Aging Study and to the Program

Project Grant at the University of Pittsburgh.

Dr. Lopez continues involved in the study of genetics and behavioral manifestations of dementing disorders. He

has been member of the panel assembled by the American Psychiatric Association to provide the guidelines for the

use of antipsychotic medication in patients with dementia [The American Psychiatric Association Practice

Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients with Dementia. American Journal of Psychiatry. 2016 May 1; 173(5): 543-546].

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Beth Snitz, PhD

Assistant Professor of Neurology

Associate Director - Alzheimer Disease Research Center Outreach, Recruitment and

Education Core

Associate Director - Alzheimer Disease Research Center Clinical Core

Dr. Snitz is a neuropsychologist with a clinical and research focus on mild cognitive impairment

in aging and early detection and prediction of Alzheimer’s disease (AD). Her research interests

also include cognitive correlates of beta-amyloid deposition as measured by Pittsburgh

Compound B (PiB) – PET imaging; subjective memory complaints; and epidemiology of

cognitive aging.

This past academic year Dr. Snitz began work on a newly funded R01 grant, ‘ALZHEIMER NEUROIMAGING-

BIOMARKERS IN PRE-CLINICAL COGNITIVE DECLINE FROM A POPULATION-BASED STUDY’. The

project will investigate in vivo brain imaging of the two neuropathological hallmarks of AD in older adults

evidencing subtle cognitive decline, specifically: Pittsburgh Compound-B (PiB)-PET to image amyloid-beta (Aβ)

plaque deposition, and [F-18]AV-1451 to image aggregated tau pathology. The study will investigate the sequence

of pathologic events early in AD and thereby inform prevention strategies regarding the timing of interventions

Dr. Snitz is PI of an Alzheimer Disease Research Center (ADRC) Project investigating subjective memory decline

with neuroimaging, psychological and cognitive assessments. She is Director of the Clinical Core of the NIA-funded

program project grant ‘In Vivo PiB PET Amyloid Imaging: Normals, MCI & Dementia’ (Klunk, PI). She is a clinical

neuropsychologist in the ADRC, and co-investigator on ‘Mild Cognitive Impairment: A prospective community

study’ (Ganguli, PI), a population study of predictors and outcomes of MCI in small-town Southwestern

Pennsylvania. She leads the Clinical Team of the newly funded U01, ‘BRAIN CONNECTOMICS IN AGING’, a

Human Connectome Project grant (Becker, PI). Dr. Snitz collaborates closely with colleagues Drs. Ganguli, Klunk,

Lopez and Becker on epidemiologic, clinical and neuro-imaging studies of cognitive aging, MCI and AD.

Epilepsy Division

Anto Bagić, MD, MSc, PhD

Professor of Neurology and Neurosurgery

Chief, Epilepsy Division

Director, Epilepsy Monitoring Unit (ECU)

Chief Scientific Advisor, MEG research

Director, UPMC MEG Epilepsy Program

Director, University of Pittsburgh Comprehensive Epilepsy Center (UPCEC)

Director, Epilepsy Fellowship

Founding Director, Center for Advanced Brain Magnetic Source Imaging (CABMSI;

2005-2009)

President, American Clinical MEG Society (ACMEGS), 2012 – 2015

Immediate Past President, ACMEGS, 2015

Dr. Bagić conducted an Outpatient Epilepsy Clinic, had major attending responsibilities in the EMU, continued to

solely provide interpretations of MEG-EEG studies of epilepsy patients and maintained a monthly Vagal Nerve

Stimulator (VNS) Clinic. Under his direction, the EMU reached a record number of admissions; the MEG Epilepsy

Program sustained its annual volume of MEG-EEG epilepsy studies, while continued Epilepsy Division team efforts

in concert with Adult Epilepsy Surgery Program and Children’s Hospital of Pittsburgh Pediatric Epilepsy Program

resulted in a Level 4 NAEC designation for both Programs (PUH and CHP). The Adult UPCEC team has been

offering the RNS® System among the leading Level IV epilepsy centers in the Country. During the

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past year, a laser ablation became a treatment option available for the selected patients with epilepsy at UPMC.

Working collaboratively with the PUH leadership, he secured the funding for another expansion of the EMU from

6 to 8 fully-equipped beds that comes with the Hospital support for 4 fully-funded epilepsy fellowship positions

annually. Dr. Bagić’s continued responsibility is to further expand the Epilepsy Program that has already grown to

include six sub-specialized adult epileptologists while continuing to direct and further develop the UPMC MEG

Epilepsy Program. UPMC Neurological Institute Epilepsy Subservice Line is the latest organizational framework

through which the PUH Epilepsy Program headed by Dr. Bagić is taking a lead in organizing, standardizing and

overall improving epilepsy care UPMC-wide.

Nationally, Dr. Bagić continued to be very active within the American Clinical MEG Society (ACMEGS) where he

is a founding member, served on the Board of Directors, as a treasurer, President and now in the role of Immediate

Past President he is working on two national surveys focused on the practice (USA MEG Centers are surveyed) and

use (NAEC Epilepsy Centers are surveyed). He is increasingly active on the Board of the National Association of

Epilepsy Centers where he is taking the lead on various specific projects.

Internationally, Dr. Bagić continues his activities within the International Society for Advancement of Clinical MEG

(ISACM) and the Magnetoencephalography International Consortium for Alzheimer’s Disease (MAGIC-AD). He

is a Chair of the upcoming international Program (“Quo Vadis Clinical MEG Worldwide?”) at the 31st International

Congress of Clinical Neurophysiology (ICCN 2018; May 1-6, 2018, Washington, DC, USA) where the very first

dialogue between the leading MEG societies (Japan, USA and Europe) will take place. During the past academic

year, Dr. Bagić presented on the major international meetings, where he also chaired various sessions, published

several articles in major journals, and has a few related articles in review and several in preparation. Recently, he

spearheaded efforts of the ACMEGS on publishing its second Position Statement (“The Value of

Magnetoencephalography (MEG)/Magnetic Source Imaging (MSI) in Noninvasive Presurgical Mapping of

Eloquent Cortices of Patients Preparing for Surgical Interventions”) in Journal of Clinical Neurophysiology.

Dr. Bagić’s research is focused on applications of MEG in studying epilepsy, language, cognition and brain

plasticity. Dr. Bagić is a co-investigator or consultant on multiple MEG-based studies ongoing at UPMC, including

NIH-funded R01 grants. Additionally, he is a site Principal Investigator on three multicenter clinical studies: The

ROSE (Radiosurgery vs Lobectomy for Temporal Lobe Epilepsy) Trail (NIH-funded), MONEAD (Maternal Outcomes

and Neurodevelopmental Effects of Antiepileptic Drugs) study (NIH-funded), and “ASCEND: Vagus Nerve Stimulation

Titration Protocol to Improve Tolerance and Accelerate Adaptation” (aka the E-40 Study, funded by the

Cyberonics/LivaNova).

Currently, the most active MEG research efforts are on studying dementia, music and brain plasticity. Over the last

few years, in the context of EMU and Surgical Epilepsy Program, research interactions with the Brain Modulation

Laboratory (Department of Neurosurgery, directed by R. Mark Richardson, MD, PhD) intensified, yielded a few

upcoming publications.

During the next year, Dr. Bagić will focus on advancing and/or finalizing some of his ongoing studies, starting new

epilepsy projects that involve connectivity analyses and combining MEG and EEG source localization in studying

intractable epilepsy, accelerating the surgical epilepsy program and expanding the Epilepsy Division. Academically,

Dr. Bagić will continue his teaching roles within the Residency Program, Epilepsy Fellowship, Clinical

Neurophysiology Fellowship, MS1 Neuroscience Course, MS4 Clinical Pharmacology, and Epidemiology Course.

Some of Dr. Bagić’s short-term goals are: ensuring sustained recruitment of fellows for epilepsy fellowship at UPMC

and organizing all Pittsburgh researchers studying any aspect of epilepsy in Pittsburgh Epilepsy Research Special

Interest Group. His clinical efforts during the next year will be centered on optimizing patient flow in the expanded

EMU, fostering the growth of the outpatient epilepsy program, including particular attention to transition and transfer

of epilepsy patients from pediatric to adult epileptologists, starting epilepsy support groups for specific

subpopulations such as patients who have undergone epilepsy surgery and intensifying divisional activities through

the Epilepsy Foundation of America.

One of Dr. Bagić’s standing goals is to engage all physician members of Epilepsy Division in various epilepsy

advocacy activities.

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Puja Aggarwal, MD

Clinical Assistant Professor

Dr. Aggarwal has been a member of the neurology faculty since 2014. She completed her

neurology residency at Ohio State University and a fellowship in Clinical Neurophysiology at

Cornell University New York Presbyterian Hospital. She continues to be an active member of

the American Academy of Neurology and American Epilepsy Society. She continues to evaluate

and treat patients with Epilepsy along with managing Vagus Nerve Stimulators. Dr. Aggarwal

Dr. Aggarwal has been a participant in overseeing fellows through overseeing fellow during the

Continuous EEG rotation.

Arun Antony, MD

Assistant Professor of Neurology

Dr. Antony joined the Epilepsy Division in 2013 after completing two years of subspecialty

fellowship training in Epilepsy, EEG and clinical Neurophysiology at the Cleveland Clinic

(Cleveland, OH). He is board certified in Neurology, Clinical Neurophysiology and Epilepsy.

Dr. Antony helped design the implantation schema templates, streamline work flow and helped

with waveform analysis in the stereo EEG (SEEG) program for seizure localization at UPMC.

Dr. Antony has special interest in treating patients with seizures not responding to medications, spells of unknown

etiology and surgical treatment of epilepsy. In addition to his Outpatient Epilepsy clinic, Dr. Antony has attending

responsibilities in Ambulatory (24-48 hour) EEG review, Continuous EEG monitoring and the Epilepsy monitoring

unit where prolonged EEG monitoring is performed to confirm if a known spell is an epileptic seizure, to diagnose

the type and frequency of seizures and to evaluate for epilepsy surgery.

His research is focused on functional connectivity in epileptogenesis, seizure spread and treatment of epilepsy.

Joanna Fong, MD

Assistant Professor of Neurology

Dr. Fong joined the Department of Neurology in September 2013 and came to us from

Cleveland Clinic where she was a clinical assistant professor in Department of Neurology

in the Epilepsy and Sleep Medicine Division. Dr. Fong received her MD in 2005 from Ohio

State University Medical Center and completed her neurology residency, epilepsy

fellowship, and sleep medicine fellowship at Cleveland Clinic in 2011. Her main focus is

the medical management of patients with epilepsy, non-epileptic behavioral spells, sleep

apnea, insomnia, sleep related movement disorders, and hypersomnia.

Dr. Fong’s activities this year included serving as attending on the continuous video EEG monitoring service

in multiple UPMC hospitals and reading all ambulatory EEG studies from UPMC Presbyterian hospital. She

works with medical students and epilepsy fellows on the epilepsy outpatient clinics. Dr. Fong also presented

multiple didactic lectures to family residents, sleep medicine residents and fellows, and neurology residents

in the past few years.

Dr. Fong has been actively participating in EEG reading at various hospital, including UPMC Shadyside,

Passavant, Presbyterian, Magee, and Mercy hospital. She also reads sleep studies from UPMC Montefiore

and Monroeville sleep lab.

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Gena Ghearing, MD

Assistant Professor of Neurology

Dr. Ghearing has been continuing to work to increase the activity of the adult surgical epilepsy

program which is now averaging approximately one surgery each week. Many of these cases

have been complicated cases which require prolonged extraoperative intracranial EEG

monitoring and cortical stimulation studies. The program is also incorporating subtraction ictal

SPECT, MEG, PET, 3T MRI and functional MRI into the evaluation with the cooperation of

colleagues. We have continued the weekly epilepsy surgery conference. This has allowed the

exchange of information and facilitated advances among those interested in epilepsy who work

in neurology, neuropsychology, neurosurgery, MRI, nuclear medicine, MEG, and other interested groups.

Dr. Ghearing’s activities this year included serving as attending on the Epilepsy Monitoring Unit service, the

Neurology Ward service and the Neurology Consult service, as well as seeing patients in the epilepsy clinic. These

rotations include teaching medical students, neurology residents, clinical neurophysiology fellows, and occasional

medicine, neurosurgery, and psychiatry residents. Dr. Ghearing also presented multiple lectures to neurology

residents on topics related to seizures as well as giving other lectures on epilepsy to other audiences including

medical students, critical care fellows, psychiatry residents, and the neurology and neuropsychiatry departments.

Dr. Ghearing continues to be the director of the EEG lab at Presbyterian Hospital, which includes 6 ambulatory EEG

machines for prolonged outpatient recordings and 12 Video EEG machines, which can be utilized for monitoring in

the ICU. We also perform upper and lower extremity evoked potentials, brainstem auditory evoked responses, and

visual evoked potentials. The video continuous ICU services perform 180-190 of studies each month at Presbyterian

and Montefiore hospitals. In addition, the EEG lab at Presbyterian Hospital continues to be a site for training

neurology residents, clinical neurophysiology fellows, epilepsy fellows, and EEG technicians.

Rick Hendrickson, PhD

Assistant Professor of Neurology

Neuropsychologist, Epilepsy Division

Dr. Hendrickson provided clinical neuropsychological services for the Epilepsy Division. His

cognitive assessments are part of comprehensive pre-surgery evaluations for patients with

epilepsy referred to the Department of Neurosurgery for improved seizure control via surgical

alternatives. He also evaluated patients with difficult to control seizures referred to the Epilepsy

Monitoring Unit for differential diagnosis and treatment planning.

In the last year, Dr. Hendrickson’s research contributed to a paper that he authored on patients

with epilepsy and non-epileptic behavioral seizures. He also co-authored a paper that evaluated the neurocognitive

outcomes of patients shortly after an anterior temporal lobectomy that was recently submitted. In addition, he co-

authored a presentation assessing the utility of simultaneous scalp and intracranial EEG in patients with intractable

seizures.

He continued to provide neuropsychological services for a collaborative study of Neurosurgery and Neurology for

patients with temporal lobe epilepsy. Dr. Hendrickson is a co-investigator on Dr. Popescu’s study of cognitive and

psychological functioning of patients with epilepsy and non-epileptic spells.

For the next year, he plans to analyze a database of psychological and neuropsychological variables for an additional

paper of patients with epilepsy and non-epileptic behavioral seizures. He will again provide neuropsychological

services with his main clinical responsibilities addressing the needs of the Epilepsy Division, primarily performing

inpatient assessments.

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Jullie Pan, PhD

Professor of Neurology

Since joining University of Pittsburgh April 2013, our laboratory has continued to work on

developments and applications of advanced MR imaging for the better understanding of epilepsy.

With the 7T human scanner, we have implemented a highly sensitive transceiver array to provide

homogeneous, high contrast and high resolution imaging. In collaboration with the Cleveland

Clinic, we have established a better than 750um isotropic resolution 3D imaging acquisition, for

which an example from an epilepsy patient is shown below (Figure 1). This increased resolution

and contrast will be examined with our team’s image processing expertise to ascertain the added information

available from the ultra-high field images. We have also advanced our ability to rapidly acquire high resolution

spectroscopic imaging at 3T and 7T, based on rosette strategies with k-space coverage. Currently, high consistency

data at a spatial resolutions of 8x8x10mm (0.64cc) covering a frontal-parietal region 48mm thick can be achieved

at 3T in 6-10min, will allow realistic and accurate whole brain MRSI with conventional imaging durations. Aspects

of this work have been presented at the 2015 International Society for Magnetic Resonance in Medicine Toronto

Canada and 2015 American Epilepsy Society meeting Seattle WA. This work is funded by R01-EB011639 and R01-

NS090417 (PI, JW Pan).

Our group has also made progress with rodent studies of epileptogenesis. With the goal of understanding the

metabolic pathophysiology that arises from prolonged seizures (status epilepticus), we have implemented a modified

Hellier Dudeck chemoconvulsant status model to generate a variable injury condition. This condition is of interest

as human epidemiology studies have found that one of the factors in status epilepticus that can influence the

subsequent development of epilepsy is seizure complexity including duration. In initial work studying

epileptogenesis following a 1.5hr and 3hr status epilepticus period, we have found many changes in several

metabolites including N-acetyl aspartate, glutamine, myo-inositol as well as T2 relaxometry. An example of this

work is also shown below (Figure 2) showing the T2 relaxometric changes and a typical spectrum from the CA3

region of the hippocampus. This work showed a metabolomics perspective on the neuronal and astrocytic changes

in the post-status time period and is currently in press with the Journal of Cerebral Blood Flow and Metabolism

2015. This work is funded by R21-NS083035 (PI, JW Pan).

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Figure 1. Ultra-high field 7T

imaging: MP2RAGE T1

weighted imaging dataset with

750um isotropic resolution from

a patient who has right sided

schizencephaly and intractable

epilepsy.

Note dpi quality of image has

been downsampled for ease of

transfer.

Alexandra Urban, MD

Assistant Professor of Neurology

Program Director for the Epilepsy Fellowship

Director of Clinical Neurophysiology Fellowship

Director of the PUH EEG Laboratory

Alexandra Popescu MD joined the Epilepsy Division in 2009 after completing a clinical

neurophysiology fellowship focused on EEG and Epilepsy at Vanderbilt University in

Nashville, Tennessee. At the conclusion of her fellowship, Dr. Popescu was awarded with the

“Clinical Neurophysiology Fellowship Award” for exceptional skills in clinical neurophysiology.

She was appointed Medical Director of Adult Epilepsy Surgery Program at UPMC in 2013. Dr. Urban also has

coordinated the Responsive Neuro Stimulation (RNS) clinic since 2015. She serves as the Medical Director of the

PUH EEG laboratory – the central EEG Laboratory for the entire UPMC System of 32 hospitals. In this position,

she leads, guides and develops clinical programs and quality studies ensuring that the laboratory meets the latest

standards of care and implements policies and procedures based on latest clinical practice guidelines (CPG).

Dr. Urban was appointed as the Assistant Program Director of the Epilepsy Fellowship in 2016 and Program Director

in January 2017, guiding 2-4 fellows per year.

Recently, Dr. Urban took the lead in the preparing the successful application for ACGME accreditation of the

epilepsy fellow which was approved for four positions annually. The ACGME Epilepsy fellowship application,

includes over 80 pages of Epilepsy fellowship policies and procedures, skills and competencies, milestones,

fellowship structure and evaluations. ACGME accreditation is a very important milestone in keeping the UPMC

Comprehensive Epilepsy Program at the forefront of the field nationally.

Dr. Urban was also elected Program Director for Clinical Neurophysiology Fellowship in January 2017.

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Figure 2. Rodent model of

epilepsy. T2 relaxometry from

hippocampal slice, (A) control

and (B) kainate treated rat. In the

kainate rate, there is increased

T2 in the amygdala, piriform

cortex with a smaller ventricle

reflecting the edematous brain.

(C) MR spectroscopy

measurement (2mm isotropic)

from CA3 region of

hippocampus showing

metabolites as indicated.

Significant changes between

kainate and control rats are

found in N-acetyl aspartate,

glutamine and myo-inositol.

Anne C. Van Cott, MD, FAAN

Neurology Service/ VA Pittsburgh Healthcare System

Associate Professor of Neurology

In the past academic year, Dr. Van Cott has continued her clinical and research work in epilepsy.

Dr. Van Cott continues to collaborate with a University of Pittsburgh colleague on a project

examining traumatic brain injury in veterans. She is the principal investigator at the VA for Dr.

Hetherington’s (Director of the Magnetic Resonance Research Center) NIH funded study to

assess metabolic changes in veterans exposed to blast injury using Multiplexed Multiband 7T

MR technology. She is collaborating with Dr. Amy Wagner on a project examining the genetic

influences on epileptogenesis and bio-susceptibility to Post-Traumatic Epilepsy.

She enjoys caring for veterans with epilepsy. She continues to serve as the director of the EEG laboratory at the VA

Pittsburgh Health Care System which is accredited by the American Board of Electroencephalographic and Evoked

Potential Technologists (ABRET) and has expanded the services provided by the laboratory.

As an Associate Professor of Neurology, she is an active member of the Neurology Department’s Medical Student

Curriculum Committee and works at the education coordinator at the VA. In the Spring of 2017, she was a Faculty

Facilitator for the Integrated Case Studies Course for the School of Medicine and served as a Neuroscience

Facilitator for the School of Medicine. She shares the organizational responsibilities for the University Department’s

Women in Neurology organization. She continues to play an active role in the education of residents, specifically

with regards to electroencephalography interpretation. She enjoys serving as a mentor to several residents and a

PhD candidate.

Dr. Van Cott also is a member in several national organizations. She is an active member of the VA Epilepsy Center

of Excellences (ECoE), serves on the Southeast ECoE Steering Committee and serves as the ECoE Chair of the

Women Veterans with Epilepsy Workgroup. Locally, she serves as a member of the Clinical Systems Improvement

Task Committee at the Pittsburgh VA.

Naoir Zaher, MD

Assistant Professor of Neurology

Dr. Zaher has been a member of the neurology faculty since 09/2015. He completed neurology

residency at Henry ford Hospital and Neurophysiology/epilepsy track fellowship at Vanderbilt

University. He is an attending in the epilepsy monitoring unit, where patients with refractory

epilepsy are admitted for evaluation of seizure focus and potential epilepsy surgery. He also

has an epilepsy clinic in which he evaluates and treats patients with seizures. During the

academic year 2016-2017, Dr. Zaher expanded his clinical work to involve more critical care

EEG monitoring

In addition to his clinical responsibilities, Dr. Zaher is interested in clinical research. He is planning to start a

retrospective study looking at the value of continuous EEG in predicting outcome in patients with intracranial

hemorrhage. He also teaches medical students rotating through epilepsy clinic, and residents and fellows in the

Neurophysiology lab at the University of Pittsburgh.

In the coming year, Dr. Zaher will continue to care for patients with epilepsy and teach medical students, residents

and fellows. He intends to expand his clinical duties by taking the role of the Director of critical care EEG, and

planning to mentor fellows interested in doing critical care EEG track fellowship.

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General Neurology Division

John J. Doyle, MD

Associate Professor of Neurology

Chief, General Neurology Division

Director, Residency Training

Dr. Doyle became Residency Program Director for the Department of Neurology in October,

2006. He has supervised resident recruitment since, and all available positions have been

successfully filled with excellent applicants. He directs the course entitled “An introduction

to clinical neurology” (“boot camp”) each year for PGY-2 residents as they start formal

neurology training. The resident complement for the program has been increased to seven adult neurology residents

per year.

Dr. Doyle was the recipient of the Program Director’s Recognition Award from the American Academy of

Neurology in 2016. The Award was presented at the meeting of the American Academy of Neurology in Vancouver,

Canada.

Dr. Doyle’s chief interests lie in clinical neurology and neurologic education. He sees patients in the outpatient clinic

where most of his clinical sessions include neurology residents who are fulfilling training requirements for continuity

clinics. The goals in the clinic are to foster the clinical application of basic neurologic science, the mastery of clinical

neurology, including the interpretation and judicious use of neurologic diagnostic tests, and to offer effective

treatment where available, Dr. Doyle anticipates that by the time the residents complete their training, they will be

competent to enter practice. At the present time, he supervises seven neurology residents on a weekly basis.

Dr. Doyle instructs neurology residents and residents in other disciplines such as psychiatry and physical medicine,

and medical students on the neurology in-patient consultation service. His commitment is six to eight weeks per

year. On average, more than 60 consultations are seen each week.

Dr. Doyle participates in didactic medical student education; he is co-director of the Neuroscience Course for the

PMS1 Medical Students. He lectures extensively in the course and participates in multiple small group case-based

sessions. He is intimately involved in planning the curriculum for the course.

Dr. Doyle has received three “Neurology Resident Teaching Awards” (2002, 2006, and 2010); the “Preceptor of the

Year Award” from third-year medical students (2010) and a national award for “Excellence in Neurologic

Education” from the American Academy of Neurology (2010). In addition, Dr. Doyle has received the “Program

Director’s Recognition Award” from the American Academy of Neurology (2016).

Dr. Doyle is board certified in Neurology and Electrodiagnostic Medicine.

Neil A. Busis, MD

Clinical Professor of Neurology

Director, Community Neurology

Chief, UPP Department of Neurology – Shadyside

Director, Neurodiagnostic Laboratory – UPMC Shadyside

Dr. Busis provided leadership for the UPP Neurology Service at UPMC Shadyside. He directed

an outpatient and consultation service with other neurologists, two physician assistants, and

internal medicine and family practice resident physicians. The active teaching service also

included third and fourth year medical students. As Director of the

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Neurodiagnostic Laboratory at UPMC Shadyside Dr. Busis worked with administration, staff and other providers to

ensure that high quality outpatient and inpatient EEGs and EMGs were provided in a timely fashion. He coordinated

routine, STAT and continuous EEG reading at UPMC Shadyside with the EEG specialists at UPMC Presbyterian-

Shadyside and coordinated EMG services with physicians from the Department of Physical Medicine &

Rehabilitation. He coordinated general neurology activities at UPMC Shadyside with the UPMC Stroke and Neuro-

Oncology Services.

Dr. Busis was again named among the Top Doctors by Pittsburgh Magazine and in Best Doctors and Top Doctors

nationally. Dr. Busis served on the Board of Directors and the Meeting Management Committee of the American

Academy of Neurology and the Coding Subcommittee of the Medical Economics and Management Committee. He

is the principle investigator of the American Academy of Neurology’s research studies on burnout, career

satisfaction and well-being in U.S. neurologists (four publications so far). He serves on the American Medical

Association’s (AMA) Current Procedural Terminology (CPT) Advisory Committee as the alternate representative

from American Academy of Neurology. He is on the steering committee of the National Academy of Medicine

Action Collaborative on Clinician Well-being and Resilience and is co-lead of its Messaging and Communications

Working Group. He has been deeply involved in neurological practice management issues including coding, billing,

payment, regulation and the move from fee-for-service to value based reimbursement. He had two publications in

Neurology this past academic year.

He lectured on a variety of topics locally, regionally, and nationally including coding, billing, reimbursement, quality

measures and burnout/career satisfaction and well-being. He was an organizer of the UPMC Neurology CME course.

He lectured on neurologist well-being and burnout at the University of Rochester and the Clerkship and Program

Directors Conference: Wellness and Burnout During Training at the American Academy of Neurology Annual

Meeting. He gave several other lectures at the American Academy of Neurology Fall Conference and Annual

Meeting on coding and billing, career choice, well-being and burnout.

Dr. Busis participated in the UPMC Shadyside Total Quality Council, helping to develop and present quality

programs in stroke, EMG, and EEG. A program to reduce venous thromboembolism on neurology inpatient services

has been successfully implemented. A program to assess and reduce neurology resident burnout is being developed.

Kelly Kay, DO

Clinical Assistant Professor of Neurology

Dr. Kay joined the Department of Neurology in 2011. She received her Doctor of Osteopathic

Medicine degree from Lake Erie College of Osteopathic Medicine in 2004 and completed her

residency in neurology at Allegheny General Hospital in Pittsburgh in 2008, followed by a

fellowship in clinical neurophysiology. Dr. Kay practices general neurology and performs

EMG/nerve conduction studies in the Monroeville office. Dr. Kay also rounds on the inpatient

neurology and consultation service on the Oakland campus and enjoys working with the

neurology residents and medical students.

Simin Khavandgar, MD

Clinical Assistant Professor of Neurology

Dr. Khavandgar is primarily focused on outpatient clinical neurology and sleep medicine

practice. She sees patients in the neurology and sleep medicine clinics at UPMC Monroeville

center. She has a special interest in the interface of neurology and sleep medicine, including

diagnosis and treatment of sleep disorders associated with movement disorders such as

Parkinson’s disease, cerebrovascular disorders, and multiple sclerosis as well as other sleep

disorders including narcolepsy, central and obstructive sleep apnea. In addition, she has

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subspecialty training in clinical neurophysiology and performs diagnostic electromyography for patients with a

range of neuromuscular disorders. Dr. Khavandgar also participates in a range of educational activities including

didactic lectures for medical students and residents, and precepting rotating neurology residents and

neurophysiology fellows. She continues to expand the scope of her educational activities at various levels, especially

as it pertains to sleep neurology. She is also looking forward to participate in clinical research opportunities on sleep

disorders in neurological disorders.

Erek Lam, MD Clinical Assistant Professor of Neurology

Dr. Lam is a general neurologist with subspecialty interest in sleep medication who practices at

UPMC Passavant and sees both inpatients and outpatients. His specialty includes sleep disorders,

specifically narcolepsy, restless legs syndrome, REM sleep behavior disorder, and other

abnormal behaviors during sleep. He has a special interest in sleep disorders in patients with

neurologic disease. Dr. Lam is board certified in neurology and sleep medicine. He interprets

sleep studies at UPMC Passavant. He continues to instruct medical students and is involved in

teaching at the University of Pittsburgh Medical School where he gives annual lectures on sleep

physiology and sleep disorders. He also provides lectures and informational sessions to the North Hills community

and UPMC. He has published several peer reviewed papers pertaining to sleep medicine and neurology previously.

Angela Lu, MD

Clinical Associate Professor of Neurology

Dr. Lu is a general neurologist who focuses on out-patient clinical care. Her practice is at the

primary office in Oakland.

Dr. Lu completed her fellowship training in clinical neurophysiology at the University of

Pittsburgh Medical Center in 2008. She utilizes this expertise in performing EMG studies at

UPMC Passavant, and interpreting EEG studies at multiple UPMC hospitals.

Dr. Lu actively participates in both medical student and resident teaching activities. She

precepts several neurology residents in their weekly out-patient continuity clinics. She also frequently works with

medical students & internal medicine residents in the out-patient clinic setting during their neurology clerkships/

rotations. She lectures to medical students on peripheral neuropathy and leads small group clinical neuroscience

sessions. She also instructs neurology residents and fellows in EEG interpretation.

Eric Ogren, MD

Assistant Professor of Neurology

Dr. Ogren continues to provide inpatient and outpatient neurological services for the Pittsburgh

and Butler Veterans Administration Healthcare Systems. During the week, he sees patients at the

Oakland VA Hospital, the H. John Heinz III Progressive Care Center and the Butler VA Hospital.

He supervises house-staff in the Monday and Tuesday Oakland VA Neurology Clinics. He is

part of the Neurobehavioral program at the H. John Heinz III VA and he’s also a consultant to

the Poly-trauma team for veterans with traumatic brain injury.

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Ajitesh Ojha, MD

Clinical Assistant Professor of Neurology

Assistant Program Director, Neurology Residency Program

During the 2016-2017, Dr. Ojha started his first year as faculty in the Department of

Neurology. He spent most of his time serving as a neurohospitalist and was actively involved

in the neurology consult and general neurology inpatient teams. As a result, he worked

extensively both with neurology residents as well as medical students, psychiatry residents

and medicine residents. A significant portion of his time was spent in clinical education of

both residents and medical students.

He also spent his clinical time at UPMC Passavant, seeing consults there on a regular basis. On his off service

weeks, he performed EMGs at UPMC Shadyside and UPMC Presbyterian, interpreted EEGs at multiple UPMC

hospitals and interpreted autonomic studies at UPMC Presbyterian.

In addition to the time spent on his clinical/educational duties, Dr. Ojha was significantly invested in neurology

resident mentoring and career growth, serving as the Assistant Program Director of Neurology. He was

involved in resident feedback/evaluation meetings, recruitment of future residents during interview season as

well as helping with initiation of quality improvement projects for the residents. His contributions to medical

education also consist of giving lectures to 1st year medical students and serving as a facilitator in their small

group sessions. In terms of research, he completed a project focusing on EMG use in ICU patients with

neuromuscular diseases which is currently under review for publication.

In the upcoming year, he plans to continue his active clinical duties while continuing to play a significant role

in both medical education and resident mentoring. He will be taking a more prominent role in recruitment of

future residents and will be serving as an interviewer while continuing his role as the Assistant Program

Director. On the clinical side, he will also be involved in the general teleneurology initiative that is scheduled

to start near the end of 2017.

Janet Waters, MD

Clinical Assistant Professor of Neurology

Chief, Women’s Neurology Division

Dr. Waters joined the Department of Neurology in July 2010. She completed her medical

training at The George Washington University School of Medicine and her neurology residency

at Mount Sinai Medical Center in New York City. She also earned an MBA at the Nance School

of Business at Cleveland State University. She is board certified in Neurology. Dr. Waters is

Chief of the Division of Women’s Neurology. She sees women with neurologic disease in

pregnancy and in the postpartum period. She also sees women with breast and gynecologic

cancer with neurologic manifestations of their disease. Together with faculty from Harvard University, she directed

the first Obstetrical Neurology Conference in Pittsburgh in October of 2016.

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Headache Division

Robert G. Kaniecki, MD

Assistant Professor of Neurology

Chief, Headache Division

Founder and Director, The Headache Center, University of Pittsburgh

Director, Headache Fellowship

Assistant Director, Neurology Residency Program

During the academic year 2015-2016 Dr. Kaniecki continued his role as Director of the

outpatient Headache Center which he founded in 2000. He remains clinically active in the

evaluation and management of headache patients, personally scheduling 300-400 patients each

month. The Headache Center at the University of Pittsburgh has developed into one of the largest headache programs

in the country with over 13,000 outpatient visits per year. It is staffed by 5 physicians and 2 physician assistants at

a state-of-the-art 3700 square-foot outpatient facility. A Headache fellow is receiving training during the 2017-2018

academic year. The Center continues to provide an assortment of medical options for the management of headache,

as well as interventional procedures of neural blockade and botulinum toxin delivery.

Dr. Kaniecki also oversees inpatient headache management program and continues to recruit for additional faculty

to staff the Headache program. In 2017, for the 7th consecutive year, Dr. Kaniecki was named to the Best Doctors

in Pittsburgh list. In 2016, for the 5th time in 14 years, Dr. Kaniecki received the Excellence in Teaching Award from

the neurology residents.

In addition to his clinical responsibilities, Dr. Kaniecki continues to participate in clinical research. Since 2006 he

has served as chairman of the scientific review committee for the Department of Neurology. He sits on the Editorial

Board for the journal Headache and since 2008 he has served as Abstracts Editor for the journal.

Since 2012 Dr. Kaniecki has served as the Director of the Headache Fellowship Training Program and since 2013

he has acted as Assistant Director of the Neurology Residency program. He serves on the residency selection

committee, the quality improvement committee, the compensation committee, and the executive committee for the

Department of Neurology. Dr. Kaniecki remains active in medical education. He delivers the headache and pain

pharmacology lectures for the first-year medical students and also participates in didactic and clinical education of

second, third, and fourth-year medical students. Lectures in the medicine, pain, and neuropharmacology programs

were also delivered again this academic year. Many residents participate in preceptorships at the Headache Center,

and Dr. Kaniecki is an active teacher on rounds, in lecture, and with journal club venues. Outside the University of

Pittsburgh system Dr. Kaniecki remains active in continuing medical education, delivering multiple invited CME

presentations during the 2016-2017 academic year. He acted as a key contributor to recent editions of the MKSAP-17 (Internal Medicine) and Continuum (Neurology) continuing education programs and in 2017 is completing work

on MKSAP-18.

During the upcoming academic year Dr. Kaniecki expects to continue his active clinical duties and participation in

medical educational programs. He intends to expand the educational opportunities in headache for the neurology

residents at the University of Pittsburgh. Plans for participation in a major multi-center clinical trial are also in

progress, and he will continue to participate in single institutional clinical studies involving the diagnosis and

treatment of patients with headache. He mentored medical student, neurology resident, and headache fellow research

projects which generated poster presentations at national scientific meetings.

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Kathy Gardner, MD

Assistant Professor of Neurology

Dr. Gardner's research is focused on the genetics of both common and rare hemiplegic forms of

migraine. She has an ongoing cohort of migraine families and hemiplegic migraineurs for

linkage and mutation analysis. Dr. Gardner also has a study ongoing at the Children’s Hospital

NF clinic to characterize headache types and frequency in subjects of all ages with NF-1 titled

“Headaches in Neurofibromatosis-1.” She is an advisor and board member for the local chapter

of the Neurofibromatosis Clinics Association and is Co-Director of the Children’s Hospital

Neurofibromatosis Clinic.

Laurie Knepper, MD

Associate Professor of Neurology

For the past 1 ½ year I have been the 3rd year Neurology Clerkship Director. We have made

many updates and revisions to our clerkship. Most importantly our end of the year evaluations,

this year note that 94% of students felt the clerkship was well organized and that they received

clear learning objectives. 90% reported that we met those goals. 90% of students rated the

overall quality of the clerkship outstanding and 92% noted that it provided an adequate

experience in Neurology. 85 - 88% felt that overall teaching was of good quality.

Students still feel they need feedback. A continued emphasis was placed on case based didactics – many attendings

and fellows took time to provide this for the 3-hour weekly student didactic sessions. Review of these case based

didactics have been excellent. This year 4 residents revised Neurology emergency cases and different residents gave

this didactic session each month. It was well received by the students. I continue to do the end of rotation NBME

board exam review with an average of 4.7/5 on my student evaluations. I also moderate, with the students via

teleconference, the pediatric neurology weekly case conference. This year our students continued to four points

above the national neurology NBME exam score. This past year, fourth year medical students matched in adult

neurology residency programs including: Mayo Clinic, University of Michigan, Mt Sinai and MGH/Brigham

Women’s. 3 students also chose pediatric neurology for their residencies. I wrote letters of recommendation for

three of these students and advised them before and during the application and interview process. This year Dr.

Kenmuir codirected and ran the four-week Stroke mini elective, it again received 4.8 /5 evaluation scores. It filled

within minutes of the course opening online for these first year UPSOM students. I presented the Neurology

Clerkship Entrustable Professional Activities Student Project at the AAMC Learn Serve and Lead conference,

November 2016. This project enabled us to address the skills our students felt they were not

learning well during their neurology Clerkship. We are now in our second year of addressing and assessing four of

the Entrustable activities with a graded EMR note review with written feedback to each student mid clerkship and

after clerkship completion. Last year, Dr. Claire Yanta and Dr. Andrew Levin assisted with this time intensive

project. This next year Dr. Stakic and Dr. Ohja are joining the note review group. We have recorded one of our

neuroanatomy online modules on the UPSOM Navigator site – Dr. Wilson Heredia designed this and recorded this.

We have been working on 2 more neuroanatomy review modules and pediatric neurology modules, these will soon

be recorded. I also teach small groups in the first-year neuroscience course, the advanced physical exam course and

4 morning sessions in the second-year Integrated Case Studies course. I have already met with students interested

in applying for neurology residency this up coming year.

I also continue to precept 2 residents in clinic and I am a resident mentor for one resident each year. I moderated

morning report every 4-6 weeks this past year.

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As a core member of the WIN neurology group, I have organized the annual new resident/fellow/faculty neurology

picnic in July and help to organize several yearly informal events. Clinical duties are unchanged. I see patients in

the outpatient headache center six half days each week. I rotate on the inpatient ward, eight weeks each year. I

enjoy teaching both residents and medical students during these times.

Josif Stakic, MD

Assistant Professor of Neurology

Dr. Stakic has been a member of the neurology faculty since 2012. He completed a headache

fellowship training at University of Pittsburgh in 2012. Currently Dr. Stakic sees patients at the

department of neurology headache center where he uses medications, natural measure strategies

and innovative injectable therapies in managing episodic and chronic headache patients. His

inpatient responsibilities included 8 weeks of service seeing general neurology patients at

Shadyside campus. Dr. Stakic enrolled in the masters program in medical education offered by

University of Pittsburgh Institute for Clinical Research Education in 2015. In 2015-2016 academic year Dr. Stakic

participated in the neuroscience curriculum mentoring project through University of Pittsburgh School of Medicine

and Nazarbayev University School of Medicine. In the following academic year Dr. Stakic will continue to care for

headache and neurology patients in the headache clinic and inpatient setting. He will continue to take classes working

towards the completion of the masters program. In addition, he plans to assist in running the first year neuroscience

course at University of Pittsburgh School of Medicine. He will continue his involvement in medical student and

resident education through didactic lectures and clinical precepting.

Barbara Vogler, MD

Clinical Assistant Professor of Neurology

Dr. Vogler joined the Department of Neurology at the UPP Headache Center in August 2006.

Since that time, she has worked with numerous University of Pittsburgh medical students and

neurology residents both in the outpatient and inpatient setting.

In addition to her clinical responsibilities, Dr. Vogler is director of the clinical research section

of the Headache Center.

Claire Yanta

Clinical Instructor of Neurology

During the 2016-2017 academic year, Dr. Yanta continued to evaluate and treat patients in the

Headache Center and acted as attending physician for the neurology consult services at both the

Presbyterian and Shadyside campuses. She also acted as a supervising physician in the outpatient

resident clinic and on the inpatient consult service on the Presbyterian campus. In addition, she

continued in her role as course director for the neurology component of the Advanced Physical

Examination course for the medical students and delivered a cognitive neurology lecture in the

neuroscience course. She also continued in her role as assistant clerkship director for the UPSOM-MSIII/IV

neurology rotation.

In the coming year, she is looking forward beginning her first year as a dual faculty member for both UPMC and

UPSOM. She will continue to act as a supervising physician in outpatient resident clinic as well as on the inpatient

neurology consult service. She will continue in her position as course instructor for the neurology component of the

APE course and as assistant clerkship director for the neurology clerkship. She will also be continuing her role as a

FAST advisor to the medical students.

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Movement Disorders Division

J. Timothy Greenamyre, MD, PhD

Love Family Professor and Vice-Chair for Academic Affairs

Chief, Movement Disorders Division

Director, Pittsburgh Institute for Neurodegenerative Diseases

Scientific Director, University of Pittsburgh Tsinghua University Scholars Program

Dr. Greenamyre is Chief of the Movement Disorders Division, Love Family Professor and

Vice-Chair of Neurology. Dr. Greenamyre established the Comprehensive Movement

Disorders Clinic, which serves as the focal point for clinical care, research and teaching of

disorders, such as Parkinson’s disease, Huntington’s disease, tremor and dystonia. The

Movement Disorders Division consists of 7 clinician-investigators, a nurse, a medical assistant and 2 clinical

coordinators. Dr. Greenamyre maintains an active clinical practice and is an investigator in several clinical studies.

Since 2009, Dr. Greenamyre has been named as one of America’s Top Physicians and as one of the Best Doctors in

America. In 2015, Dr. Greenamyre was inducted into the Association of American Physicians, an honor extended to

individuals with outstanding credentials in biomedical science and/or translational biomedical research.

Dr. Greenamyre is Director of the Pittsburgh Institute for Neurodegenerative Diseases (PIND), an interdepartmental,

interdisciplinary institute that occupies the 7th floor of the new Biomedical Science Tower 3. The PIND consists of

approximately 100 faculty, postdocs, students and staff in an open-lab, collaborative environment – and is dedicated

to the study of neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s diseases, as well as

ALS, MS and other related disorders. In the PIND, there is an emphasis on defining disease mechanisms with the

ultimate goal of developing new diagnostic and therapeutic modalities.

In terms of teaching, Dr. Greenamyre serves on several PhD thesis committees and as the primary mentor on K-

awards for junior faculty, and he is the supervisor of several postdoctoral research fellows. He has mentored 25

postdoctoral fellows and his previous trainees have been very successful. Most have remained in academia, where

they range from Full Tenured Professor (and Residency Director) to Assistant Professor, tenure track. Other trainees

have gone into industry (Roche, Merck, Organon, and Shire) or taken ‘non-traditional’ positions, including CEO of

the Michael J. Fox Foundation. He has also mentored 3 MD-PhD students.

Dr. Greenamyre is engaged in both clinical and basic laboratory research. His work is funded by NINDS, NIEHS,

the American Parkinson Disease Association, the Parkinson’s Disease Foundation and the Michael J. Fox

Foundation. He is an investigator in the Huntington Study Group and the Parkinson Study Group. His laboratory

investigates basic mechanisms of neurodegeneration. He is a member of the Scientific Advisory Board of the

Michael J. Fox Foundation and the Parkinson’s Disease Foundation and the Advisory Board of the Neurological

Institute “C. Mondino” in Pavia, Italy. He is Editor-in-Chief of Neurobiology of Disease and MedLink Neurology

and a member of the editorial boards of several other scientific journals, including the Journal of Clinical Investigation.

Sarah B. Berman, MD, PhD

Assistant Professor of Neurology

Dr. Berman has been a member of the neurology faculty since 2005, after completing neurology

residency and fellowship training at the Johns Hopkins University. She continues to be an

active member of the Movement Disorders Division and treats patients with Parkinson’s

disease and other movement disorders as part of the Comprehensive Movement Disorders

Clinic. In addition, she continues to evaluate and manage patients with deep brain stimulators

(DBS) implanted for Parkinson’s disease, tremor, and dystonia.

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She oversees management and programming of stimulators, other aspects of treatment, and evaluations and referrals

for new patient candidates. Since 2008, she also evaluates patients at the Alzheimer’s Disease Research Center.

Dr. Berman is also a principal investigator with the Pittsburgh Institute for Neurodegenerative Diseases (PIND),

where she continues to be engaged in an active research program focusing on the role of mitochondria in

neurodegenerative diseases, particularly Parkinson’s disease (PD). Dr. Berman’s research focuses on the role of

mitochondrial dynamics in neurodegenerative diseases. Mitochondria, the energy-producing organelles in cells, are

dynamic in neurons, undergoing frequent division (fission) and fusion, and being transported in a regulated fashion.

These processes are critical for synapse function and formation, programmed cell death mechanisms, and protection

of mitochondrial DNA, and specific defects in mitochondrial fusion genes cause neurodegenerative diseases.

Mitochondrial dynamics have been increasingly implicated in neurodegenerative diseases, particularly PD, but these

mitochondrial processes have been very difficult to study directly, particularly in the brain. Using novel

methodology, Dr. Berman’s laboratory directly studies the role of mitochondrial dynamics in neurotoxicity of PD

models and aging, and her results have suggested that neurotoxicity can be affected by altering mitochondrial

dynamics. This year, Dr. Berman has five-year funding from the NIH National Institute of Neurologic Disorders

and Stroke and funding from the Parkinson Disease Foundation (PDF) for a collaborative project with Dr. Edward

Burton in the PIND, as well as PDF postdoctoral support for a separate project.

Dr. Berman continued as an active participant in the clinical training of residents and medical students this year

through lectures for neurology residents, and for the third-year medical student neurology lecture series. In addition,

she has continued to provide lectures around the academic community. She also provided clinical teaching to

residents and medical students during inpatient attending duties and outpatient clinics. She currently mentors two

postdoctoral fellows as well both an undergraduate and medical student.

Dr. Berman also continued her involvement in service to the PD patient community and sits on the Board of Directors

of the National Parkinson Foundation chapter, the Parkinson Foundation of Western Pennsylvania. This past year,

she worked with the Foundation to establish the monthly presence of the Foundation’s outreach director in the

Movement Disorders clinic, in order to provide information about available services and programs to any interested

patients with PD. She has also continued to serve on the United Mitochondrial Disease Foundation grant review

committee as well.

Over the course of the academic year Dr. Berman will continue to expand her research into mitochondrial

involvement in neurodegenerative diseases and will continue to publish and present her findings. She will continue

her clinical activities and expansion of the deep brain stimulator program in the Movement Disorders Division. She

will continue her work with the Alzheimer’s Disease Research Center. She plans to continue resident and medical

student teaching activities, and community service activities through involvement with the local Parkinson’s patient

advocacy group, the United Mitochondrial Disease Foundation, and educational outreach forums with local patient

support groups.

Edward A Burton, MD, DPhil, FRCP

Associate Professor of Neurology

Associate Professor of Molecular Genetics and Biochemistry

UPMC Endowed Chair in Movement Disorders

Dr. Burton is a movement disorders neurologist specializing in the diagnosis and

management of Parkinson’s disease (PD), progressive supranuclear palsy (PSP) and

dystonia. The central aim of Dr. Burton’s research work is to understand the mechanisms

underlying pathogenesis in these conditions and to develop more effective therapies to

control symptoms and mitigate disease progression. The Burton lab has taken two

complementary approaches to investigating the pathogenic mechanisms underlying these conditions:

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1. The zebrafish has many potential advantages for the study of neurological diseases and is especially

suitable for screening approaches to identify genetic and chemical modifiers, and to study gene-

environment interactions. In addition, zebrafish provide opportunities to carry out in vivo imaging studies,

since larvae are translucent. Dr. Burton’s group has identified and characterized the zebrafish homologues

of human synucleins and torsins implicated in PD and dystonia, generated transgenic and knockout

zebrafish models that replicate many of the biochemical and pathological features of PD, PSP, and

dystonia, and developed high-throughput neurobehavioral assays suitable for drug discovery applications

in these models.

2. Recombinant viral vectors can be used to deliver genetic material, including short RNA sequences that

reduce expression of genes involved in disease pathogenesis, to the brain. Dr. Burton’s group developed

a viral vector that targets the SNCA gene implicated in Parkinson’s disease; the vector reduces expression

of α-synuclein in the mammalian brain in vivo after intra-cerebral inoculation. In collaboration with J.

Timothy Greenamyre MD, PhD, Dr. Burton’s group showed that α-synuclein knockdown prevents motor

abnormalities and neurodegeneration in a rat model of Parkinson’s disease caused by exposure to an

agricultural pesticide implicated in the etiology of sporadic PD. These exciting results suggest that

therapies targeting α-synuclein may be useful in preventing the progression of PD.

Franca Cambi, MD, PhD

Professor of Neurology

Dr. Cambi joined the Department of Neurology at the University of Pittsburgh in June 2014.

Dr. Cambi’s research is focused on the functional, biochemical, molecular and clinical

underpinnings of myelin disorders. Her work has ranged from investigations on the basic

mechanisms that regulate oligodendrocyte differentiation and myelin formation to the

understanding of how disruption of their regulation leads to human myelin disease. In the

academic year 2016-17, her research group has shown that GSK3b is a regulator of

oligodendrocyte apoptosis using two experimental models of demyelination, toxic (cuprizone) and immune

mediated (Experimental Allergic Encephalomyelitis or EAE). Apoptosis is recognized as the main mechanism of

oligodendrocyte loss in Multiple Sclerosis caused either by immune mediated injury or a direct degenerative process.

The cuprizone is a model of degenerative oligodendrocyte loss and the EAE is a model of immune mediated

oligodendrocyte loss. By using a novel inducible conditional knockout (cKO) of GSK3b in mature OL, we have

shown that depletion of GSK3b protects OL from cell death induced by cuprizone and reduces demyelination.

Specifically, we show that GSK3b-deficient OLs are protected against caspase-dependent apoptosis resulting in

higher number of surviving mature OL and reduced activation of astrocytes and microglia. At peak of demyelination,

there is significant preservation of myelinated axons in the GSK3bcKO. These data demonstrate that GSK3b is pro-

apoptotic for caspase-dependent of oligodendrocytes and its depletion is sufficient to promote survival of

oligodendrocytes and attenuate myelin loss (manuscript in preparation). In preliminary studies with the MOG

induced EAE, we show that depletion of oligodendrocytic GSK3b attenuates the clinical course of motor deficits,

reduces OL loss and is associated with less demyelination. To gain an understanding of early molecular changes that

may mediate this protection and identify genes that are differentially expressed in the GSK3b cKO vs. controls, we

have performed gene-profiling studies by RNA Seq. We have found increased expression of “protective genes”

involved in apoptosis, survival and mitochondrial function in the GSK3bcKO and these represent targets for drug

development. These studies have discovered a novel previously unexplored function of GSK3b in OL cell death and open a new area of research aimed at target identification.

To determine the role of oligodendrocytes in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), we have

focused on a gene FUS, which is mutated in inherited and sporadic ALS and in Frontotemporal Lobe Dementia. We

have generated a cKO in which FUS is depleted in oligodendrocytes. The initial phenotypic characterization of the

FUS OL cKO has revealed an interesting behavioral phenotype consistent with hyperactivity and impulsivity.

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We have characterized motor function and activity longitudinally in the same cohorts of FUS fl/fl (FUS littermates)

and FUS OL cKO mice. Statistically significant interactions between genotype and age were identified in the FUS

OL cKO vs. FUS littermates for vertical time. Because vertical activity represents an exploratory behavior, the

greater vertical activity would suggest hyperactivity. Furthermore, the time spent in the center of the open field was

higher for the FUS OL cKO vs. FUS fl/fl littermates. Exploration of the center over periphery is an indication of

reduced anxiety-like behavior and would suggest impulsivity in the FUS OL cKO mice. Our collaborator Dr. Zhu

at the University of Kentucky has generated a cKO in which FUS is depleted in motor neurons where to examine

the role of FUS in motor neuron degeneration and loss.

Dr. Cambi has participated in residents teaching and clinical training during resident’s rotation in the neurology

outpatient and inpatient services. In addition, she has worked with one of the Movement Disorders Fellows in her

outpatient clinic.

In Academic year 2017-2018, we will perform molecular studies to examine the mechanisms by which GSK3b

protects oligodendrocytes against immune and non-immune apoptosis with the goal of identifying targets that can

be engaged in treatment strategies. We will characterize the spatial and temporal expression of selected genes

identified by RNA Seq in both models of demyelination. We will correlate their temporal and spatial expression

with OL cell loss and glial activation. These genes may represent novel targets for potential therapeutic interventions

in MS.

The initial characterization of FUS cKO in oligodendrocytes has revealed an unanticipated phenotype consistent

with hyperactivity and impulsivity. These findings are clinically relevant to the cognitive and behavioral defects

caused by FUS mutations in human disease and suggest that FUS deficient OL may contribute to cognitive deficits.

We will characterize further the behavioral defects by testing anxiety, exploratory and sociability behaviors in FUS

OL cKO and littermates. We will elucidate the neuroanatomical substrate by examining cortical and hippocampal

neuron number and their dendrite arborization. We will examine whether age-dependent motor neuron loss occurs

in the FUS cKO.

Dr. Cambi plans to continue her involvement with resident teaching and training in clinical settings and formal

lectures.

Eric K. Hoffmann, PhD

Research Assistant Professor of Neurology

Pittsburgh Institute for Neurodegenerative Diseases

Eric K. Hoffman, PhD, is conducting investigations to develop cell culture models of the

neurodegenerative processes associated with Parkinson’s disease (PD). Research efforts are

focusing on the use of CRISPR/Cas9 gene editing technology to generate knockout and knock-

in cell lines targeting genes linked to PD. Specific genes under investigation include the

LRRK2 kinase gene and the alpha synuclein gene. Point mutations in these genes have been

increasingly implicated in familial PD. Ongoing studies are characterizing mutations in the alpha synuclein gene

and how these alterations may influence aggregation of this protein. Also under investigation are cell lines containing

PD associated mutations in the LRRK2 gene. These lines are currently being characterized to determine the effect

these mutations have on kinase activity. Future studies will involve the use of these cell culture models under

conditions of oxidative stress to better understand how this factor contributes to the process of neurodegeneration.

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In the coming academic year, Dr. Hoffman plans to continue his research efforts on the mechanisms of oxidative

stress and neurodegeneration in Parkinson’s disease. Studies will focus on the use of CRISPR/Cas9 genome editing

methods as a means to further define the function of proteins that have been implicated in the etiology of Parkinson’s

disease.

In the coming academic year, Dr. Hoffman plans to continue his research efforts on the mechanisms of oxidative

stress and neurodegeneration in Parkinson’s disease. Studies will focus on antioxidant gene expression in response

to oxidative stress and the use of CRISPR/Cas9 genome editing methods as a means to further define the function

of proteins that have been implicated in the etiology of Parkinson’s disease.

Houman Homayoun, MD

Assistant Professor of Neurology

Dr. Homayoun is interested in clinical aspects of various movement disorders. His primary

interest is in chronic management of patients with Parkinson’s disease, atypical

parkinsonism, essential tremor, dystonia, tic disorders and Tourette Syndrome, Huntington’s

disease, medication-induced dyskinesia, myoclonus, blepharospasm, hemifacial spasm,

cerebellar ataxia, as well as uncommon movement disorders. He has a special interest in

the surgical treatment of movement disorders through deep brain stimulation. Dr.

Homayoun is the medical director of the multidisciplinary deep brain stimulation program at University of

Pittsburgh Medical Center and participates in pre-surgical assessment and post-surgical management of deep

brain stimulation therapy for patients with Parkinson’s disease, essential tremor, and dystonia. In this regard,

his main role is in patient selection and post-surgical programming of deep brain stimulation. This area is also

a focus of his clinical research interests as well. In addition, Dr. Homayoun is participating in the treatment of

patients with different movement disorders, primarily dystonia, with Botulinum Toxin injection. When needed,

he uses electromyogram (EMG) guidance for botulinum toxin injection into limbs and neck. Along with his

clinical duties, Dr. Homayoun also has a great interest in teaching neurology to residents and medical students

in both outpatient and inpatient settings and participate in didactic courses for neurology and internal medicine

residents.

Samay Jain, MD

Assistant Professor of Neurology

Clinical Director, Movement Disorders Division

Dr. Jain is Clinical Director of the Movement Disorders Division and Assistant Professor of

Neurology. He works in the Comprehensive Movement Disorders Clinic at University of

Pittsburgh Medical Center. Dr. Jain received a B.A. in Cognitive Science and M.D. from the

University of Virginia. He then went to the Cleveland Clinic for his Residency in Neurology,

followed by a Movement Disorders fellowship in the Neurological Institute at Columbia

University in New York City.

Dr. Jain is interested in developing accurate and early clinical diagnosis techniques and therapy for movement

disorders, as well as complications later in disease. He has presented research pertaining to Parkinson disease,

Tourette syndrome, essential tremor, dystonia, myoclonus, encephalitic movement disorders, historical neurology

and pediatric movement disorders. Currently he is investigating the non-motor features of Parkinson disease with

funding from the National Institutes of Health. This project aims to improve diagnosis and treatment of Parkinson

disease with assessments of non-motor features using clinical and physiologic measures. He is also site investigator

for a trial of exercise in Parkinson disease patients. Dr. Jain is also coordinating studies about Parkinson disease with

the Department of Epidemiology in the University of Pittsburgh Graduate School of Public Health. He has received

funding for his work from the NIH, Michael J. Fox Foundation, National Science Foundation, Tourette Syndrome

Association, and pharmaceutical companies.

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Dr. Jain has also established a movement disorder research registry for patients and a protocol for videographing

movement disorder patients. These videos are archived in a database where they are used for clinical, teaching and

research purposes. He coordinates Movement disorder video rounds for faculty, staff, medical education and health

care personnel. These rounds serve as a platform for discussion of movement disorders seen in clinic, helping

establish a collaborative and educational environment for patient care and education. Dr. Jain also regularly teaches

medical students, and helps coordinate a rotation for residents in the Movement disorders division. Dr. Jain is

director of the University of Pittsburgh Movement Fellowship.

In 2014, Dr. Jain lead team SPark which won the Pitt Innovation Challenge. SPark is a smartphone / smartwatch for

Parkinson disease. SPark uses motion sensors in smartphones and smartwatches, to detect and predict motor

problems and their relation to medication dose. It then optimizes medication schedules, which can be reviewed by

clinicians and sent to patients for real-time monitoring and efficient, easy communication.

Valerie Renee Suski, DO

Clinical Assistant Professor of Neurology

Clinical Director – Movement Division

Co-Director – Movement Disorders Fellowship Program

Dr. Suski joined the Department of Neurology in January 2008 after completing her Neurology

residency at Virginia Commonwealth University Health System/Medical College of Virginia

and a clinical Movement Disorders fellowship at Duke University.

Dr. Suski is an active member of the Movement Disorders Division providing evaluation and

treatments including botulinum toxin and deep brain stimulator programming to patients with a wide variety of

movement disorders.

She has been the director of the UPMC Huntington's Disease Clinic since July 2009. Since 2015, Dr. Suski was

awarded the Huntington’s Disease Society of America (HDSA) Center of Excellence and a grant that enabled her to

build this clinic. Now, the clinic is a multidisciplinary, including specialists in neurology, social work, genetic

counseling, physical therapy, occupational therapy, speech therapy, nutrition and clinical trials. It provides care for

both patients with Huntington's disease and their families in a ‘one-stop-shop’ fashion. She is a member of the

Huntington’s Study Group and is currently participating in 5 Huntington’s disease clinical trials.

Dr. Suski provides the services of the Movement Disorders Clinic through Telemedicine once a month to a remote

community location where this subspecialty is needed. She is especially interested in non-motor complications in

Parkinson's disease, atypical Parkinsonism, dystonia, tremor and Huntington's disease. She is also extremely active

in service to the Parkinson Support Group and Huntington Support Group community in the Western Pennsylvania

region.

Dr. Suski has been active in the clinical training of Neurology residents via the outpatient clinics, inpatient

Neurology ward and consultation services. She will be supervising the weekly Neurology Resident Continuity

Clinic. She also participates in medical student education, teaching them in the outpatient clinics and during the

inpatient services. In 2017, she became the Clinical Director of the Movement Disorder and co-Director of the

Movement Disorders Fellowship.

Over the course of the 2017-2018 academic year, Dr. Suski plans to continue her clinical activities and involvement

in the Comprehensive Movement Disorders Clinic. Other plans include curriculum development for the Movement

Disorders fellows and neurology residents with clinical skills teaching and assessment and deeper involvement in

medical student teaching, and academic writing.

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Neurocritical Care

Lori Shutter, MD, FCCM, FNCS

Professor, Critical Care Medicine, Neurology and Neurosurgery

Vice Chair of Education, Department of Critical Care Medicine

Director, Neurocritical Care Fellowship Program

Medical Director, Neurovascular & Neurotrauma ICUs

Dr. Shutter is the Vice Chair for Education in the Department of Critical care Medicine, directs

the Multidisciplinary Critical Care Fellowship Training Program, serves as medical director of

the Neurovascular and Neurotrauma ICUs, and leads development of the Neurocritical Care

(NCC) Program. Her clinical work is primarily in the Neurovascular and Neurotrauma ICUs where she cares for

patients with stroke, subarachnoid hemorrhage, status epilepticus, and traumatic brain injury.

During the past academic year Dr. Shutter has been participating in the Hedwig van Ameringen Executive

Leadership in Academic Medicine (ELAM) Fellowship. This prestigious and highly competitive program provided

her with intensive leadership training that included extensive coaching, networking and mentoring opportunities

aimed at expanding the national pool of qualified women candidates for leadership in academic medicine, dentistry

and public health. For the second year in a row she received a Presidential Citation from the Neurocritical Care

Society, and was named Faculty of the Year by the fellows in the Department of Critical Care Medicine.

She has lead efforts to strengthen collaborative relationships between critical care and the neurosciences through

educational activities, creation of clinical practice guidelines, and facilitating quality improvement and research

activities. Dr. Shutter continues her work with the Neurology Residency Curriculum Committee, as well as the

educational training and rotations in NCC for the Neurology Residency Training Program. She continues to actively

mentor neurology residents who are interested in NCC fellowship training.

NCC research activities occur both on an individual level and through collaborations with Neurosurgery, Neurology

and Emergency Medicine. Current projects in which Dr. Shutter has a leadership role include SHINE to evaluate

glucose control methods after stroke, Neurological Emergencies Treatment Trial (NETT) Network , and a study

looking at goal-directed management of neurocardiac injury after subarachnoid hemorrhage.

Sherry Chou, MD, MSc, FNCS

Visiting Associate Professor

Dr. Chou is a board-certified neurologist with subspecialty training and board certifications in

critical care and vascular neurology. Dr. Chou’s clinical practice focuses on patients with

critical injuries to their central nervous system. Her research focuses on the use of human

molecular biomarkers to probe mechanisms and predict outcomes in acute brain injury

conditions such as subarachnoid hemorrhage (SAH) and hypoxic ischemic brain injury from

cardiac arrest. She is funded with a K23 award, and the goals of this work include: 1) to better

define human pathophysiology of SAH-related vasospasm and brain injury using molecular

biomarkers, 2) to develop novel diagnostic molecular biomarkers in SAH, and 3) to define novel molecular

therapeutic targets for secondary brain injury in SAH. Dr. Chou also participates as co-investigator in multicenter

clinical trials in acute brain injuries including ischemic stroke, intracerebral hemorrhage, SAH, and traumatic brain

injury.

Dr. Chou has published over 50 papers, reviews and book chapters, and has received numerous honors for her

research and scholarly work contributions.

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Bradley Molyneaux, MD, PhD

Assistant Professor of Neurology

Dr. Molyneaux has been a member of the neurology faculty since 2013. He completed

neurology residency and neurocritical care fellowship at Massachusetts General Hospital and

Brigham and Woman’s Hospital at Harvard University. He shares an appointment in the

Department of Critical Care Medicine and is an attending neurointensivist in the Neurovascular

and Neurotrauma Intensive Care Units, where the patients he cares for include those with stroke,

subarachnoid hemorrhage, status epilepticus, and traumatic brain injury. He is also a member of

the Post Cardiac Arrest Service, providing consultative neurocritical care to patients after cardiac arrest.

Dr. Molyneaux is the site principal investigator for several multicenter clinical trials initiated during the past year,

including ATACH-II, which is testing whether early, intensive antihypertensive treatment is beneficial in

intracerebral hemorrhage, and GAMES-RP, which is testing whether glyburide can ameliorate malignant edema

after large ischemic strokes. As a member of the Post Cardiac Arrest Service, he is engaged in collaborative research

focused on optimizing the management of patients after cardiac arrest to improve outcome.

As a principal investigator in the Pittsburgh Institute for Neurodegenerative Diseases (PIND), Dr. Molyneaux’s

laboratory is investigating mechanisms of injury and repair of the cerebral cortex. By purifying individual subtypes

of projection neurons from the developing neocortex and sequencing their transcriptomes, he has identified

transcription factors that play critical roles in cortical projection neuron development, discovered novel noncoding

RNA’s that are unique to individual subtypes of neurons, and gained new insight into the complexity of the cortical

transcriptome. He is applying similar methods to identify new mechanisms of neuroprotection and plasticity after

injury.

Dr. Molyneaux teaches medical students, residents, and fellows who rotate in the neurocritical care units at the

University of Pittsburgh Medical Center. He is also the faculty advisor for the weekly Neurovascular and

Neurocritical Care lecture series, teaches in the medical student first year basic neuroscience course, and gives

lectures as part of the Critical Care Medicine Fellowship core lecture series.

In the coming year, Dr. Molyneaux will continue to care for patients in the Neurovascular and Neurotrauma Intensive

Care Units and teach medical students, residents and fellows. He will continue developing his basic and clinical

research program investigating mechanisms of neuroprotection and repair in the setting of stroke and traumatic brain

injury.

Ruchira Menka Jha, MD

Clinical Instructor Critical Care Medicine

Dr. Jha’s research focus is on cerebral edema using traumatic brain injury as a model under the

mentorship of Dr. Patrick Kochanek at the Safar Center for Resuscitation Research. Her specific

interest is on a pathway involving sulfonylurea receptor-1 and evaluating the role of this pathway

from multiple translational angles in human subjects as well as animal models. She is also

exploring this and related pathways in other neurological diseases that involve cerebral edema

such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage. Her current work is

supported by the NIH KL2 TR001856 grant.

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Research Projects over the past year:

▪ Characterization of the role of Sulfonylurea Receptor (SUR1) in cerebral edema in a combined injury mouse

model of controlled cortical impact and hemorrhagic shock.

This project involves evaluation of attenuation of cerebral edema by SUR1 blockade using the existing FDA

approved medication, Glyburide/Glibenclamide. A temporal-spatial map of SUR1 expression is also being

generated.

▪ Investigating whether SUR1 is measurable/quantifiable in human cerebrospinal fluid from patients with severe

traumatic brain injury. We have demonstrated that it is feasible to quantify SUR1 protein in human CSF in

traumatic brain injury. Levels are undetectable in controls, and elevated in traumatic brain injury. The trajectory

of Sur1 appears to correlate with measures of cerebral edema. Current studies are ongoing in a larger cohort of

patient to validate our findings.

▪ Investigating the impact of genetic polymorphisms in the SUR1 gene (ABCC8) on the development of cerebral

edema in patients with severe traumatic brain injury. Our work has revealed multiple single nucleotide

polymorphisms (SNP) that are associated with measures of cerebral edema and outcomes. The goal of this

project is to explore the potential functional significance of these SNPs.

Neuroimmunology/Multiple Sclerosis

Rock Heyman, MD

Associate Professor of Neurology

Chief, Division of Neuroimmunology/Multiple Sclerosis

Dr. Rock Heyman provides direct clinical care for over 1600 people with Multiple Sclerosis

(MS) and related disorders. He has a system for comprehensive care which includes not only on

site and in system multi-disciplinary care, but also integrates support services from many other

health and community programs including innovative programs to address domestic violence

issues and even support for companion animals of people with MS. He has developed the

department of neurology’s on-site infusion center, where both FDA approved and investigational

agents are given.

Dr. Heyman is an active advocate for people with MS as well as health care professionals treating and researching

MS. He devotes his efforts at the national level to working with the National MS Society (NMSS), serving on their

Medical Advisory Board (executive committee) and various task forces. He is a core member of the Comprehensive

Care Center Affiliation committee. Regionally Dr. Heyman serves the Allegheny District Chapter of the NMSS on

the Board of Trustees (executive committee), medical advisor, research advocate, and chairman of the Healthcare

Advisory Committee. Dr. Heyman also is a member of the Consortium of MS Centers abstract review committee.

Dr. Heyman’s educational efforts also center on Multiple Sclerosis. He lectures to the University of Pittsburgh

medical, physical therapy, and occupational therapy students as well other regional health care professionals. Dr.

Heyman is the lecturer for the medical school’s classes on MS and related disorders and teaches in the first year

medical school neuroscience small group sessions and problem based learning sessions. He has assisted in the

development of course materials for the Neuroscience Course. He has presented numerous CME programs

regionally and nationally as well as producing enduring CME materials for physicians and other health care

professionals as well as educational works (brochures, videos) for patients nationally. The clinical care he provides

at the Kaufmann Building site usually also involves teaching medical students, neurology residents, and fellows in

clinical MS care and spinal cord injury medicine. Dr. Heyman believes strongly in patient education and he supports

numerous patient support and education groups throughout the region and assists with both regional and national

media issues regarding MS.

Dr. Heyman is involved in all of the division’s multi-center research trials, as either a principle or co-investigator.

He currently supports research activities related to MS and Neuroimmunology in the department of Genetics

(leukodystrophy) as well as with Children’s Hospital White Matter Disorders program. He serves as either a

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treating physician or blinded examiner in trials of MS and is certified in the use of the EDSS and MSFC rating

scales. He has developed a Lumbar Puncture Clinic which assists patients, referring physicians, and research trials

with efficient acquisition of spinal fluid using state of the art techniques.

Dr Heyman plans continued expansion of his and his division’s services in all aspects of his mission, clinical care,

education, research, and advocacy.

Zongqi Xia, MD, PhD

Assistant Professor of Neurology and Biomedical Informatics

Dr. Xia joined the Department of Neurology in 2016 and holds a secondary appointment in the

Department of Biomedical Informatics. He is a core faculty member in the Pittsburgh Institute

for Multiple Sclerosis Care and Research and a principal investigator in the Pittsburgh Institute

of Neurodegenerative Diseases. He completed clinical training at Harvard-affiliated Partners

Neurology Residency Program (at Brigham and Women’s Hospital and Massachusetts General

Hospital) in 2009 and post-doctoral fellowship at the Brigham and Women’s Hospital, Harvard

Medical School and Broad Institute of Harvard University and Massachusetts Institute of Technology in 2013.

Dr. Xia leads the Laboratory of Translational Neurology and Neuroinflammation. His collaborative interdisciplinary

research team harnesses multi-dimensional patient-derived information (genomics, transcriptomics, epignomics,

microbiomes, immune profiling, electronic health records, biometric measurements, neuroimaging, cognitive

performance, and social structure) and deploys integrative quantitative science approaches to gain insights into the

underlying disease process and translate these findings into the clinical arena. The overall mission of his research

program is to bring precision medicine to multiple sclerosis (MS) and other related disorders of neuroinflammation

and neurodegeneration by providing individualized risk prediction,

prevention, and management.

Currently, there are three ongoing research initiatives. First, the research group is participating in a multi-centered,

prospective cohort study of individuals at risk for MS. Investigating the risk factors of MS and mapping the sequence

of events leading to the onset of disease will pave the way to ultimately test primary prevention strategies in high-

risk individuals. Second, the research group is conducting a longitudinal prospective cohort study to investigate the

biological and clinical predictors of disease course and treatment response in MS. Gaining insights into the factors

that influence the variable patient response to treatment and the diverse trajectories of disease progression in MS

will be the key to provide individually tailored therapy. Third, the research group is developing computational

approaches to ascertain treatment response and testing algorithms that predict treatment response using electronic

health records data. Tools that leverage real-life clinical data for outcome prediction in chronic neurological

disorders have the potential for widespread dissemination at the point of care.

Dr. Xia currently receives funding from two NIH grants: K08 and R01. In addition, Dr. Xia is the site PI of the

International Multiple Sclerosis Microbiome Study (iMSMS). The goal of this consortium project is to investigate

the gut microbial profiles characteristic of multiple sclerosis patients through the use of genetic and molecular

biology techniques and study the extent to which an individual’s genetics affect the gut microbiome. Finally, Dr.

Xia is the site PI of two multi-center clinical trials: (1) PCORI-funded trial called “Discontinuation of Disease

Modifying Therapies (DMTs) in Multiple Sclerosis (MS)”; (2) University of Texas Southwestern-sponsored trial

called “Multi-center, randomized, double-blinded assessment of Tecfidera in extending the time to a first attack in

radiologically isolated syndrome (RIS) (ARISE)”.

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Dr. Xia has published five peer-reviewed articles, including one first author research article in JAMA Neurology,

two senior author articles in Neurology and an editorial in the NEJM.

Islam Zaydan, MD

Assistant Professor of Neurology

Dr. Zaydan joined the Department of Neurology in October 2010. He completed his Internal

Medicine training in Egypt and in Marshall University SOM. His medicine training was

followed by a Neurology residency and a clinical Neuro-Ophthalmology fellowship at Virginia

Commonwealth University Health System/Medical College of Virginia. He was on the faculty

at Virginia Commonwealth University Health Systems for 4 years following his training.

Dr. Zaydan is an active member of the Comprehensive UPMC Multiple Sclerosis Center

providing evaluation and treatments of patient with central demyelinating disease. This is a multidisciplinary center

consisting of physicians, social workers, physical therapists, and clinical trial coordinators that provides care for

both patients with Multiple Sclerosis, Devic’s disease and their families. He was a board member of the Virginia

Chapter of the MS society and is currently participating in several Multiple Sclerosis clinical trials.

Dr. Zaydan is a fellowship trained neuro-ophthalmologist and holds a joint appointment at the UPMC

Ophthalmology Department (UPMC Eye and Ear Institute)/Neuro-Ophthalmology Division where he provides

evaluations and treatments of various neuro-ophthalmologic problems including ocular motility disturbances, optic

nerve diseases, and visual field/perception disturbances. He has written several chapters on the striate cortex and

cerebellum and has presented at the North American Neuro-Ophthalmology Society annual meetings.

Dr. Zaydan is especially interested in optic nerve diseases, as well as ocular motor and visual perception

complications of MS and is active in service to the Multiple Sclerosis Support Group community in the Western

Pennsylvania region.

Neuromuscular Diseases

David Lacomis, MD

Professor of Neurology and Pathology

Chief, Division of Neuromuscular Diseases

Director of Clinical Research, Live Like Lou Center for ALS Research

Co-Director, Clinical Neruophysiology Fellowship Program

Dr. Lacomis is the director of the Muscular Dystrophy Association Clinic and MDA-ALS Center

and the Director of Clinical Research for the Live Like Lou Center for ALS Research in the

University of Pittsburgh Brain Institute, specializing in amyotrophic lateral sclerosis (ALS),

myasthenia gravis, and muscle diseases. He is the co-director of the EMG Laboratory at UPMC

Presbyterian and the director of the Autonomics Laboratory, and he also serves as an assistant director of the Clinical

Neurophysiology Fellowship Program in charge of the EMG component. He is in charge of the Neuromuscular

Pathology Service. He remained active in teaching medical students in the Neuroscience Course and housestaff from

Neurology and Pathology. Dr. Lacomis was again named among the Top Doctors by Pittsburgh Magazine and in

Best Doctors and Top Doctors nationally.

Dr. Lacomis has been involved in a number of major ALS research projects in the past year. He is the site principal

investigator (PI) for an ongoing multi-center study for the discovery and validation of biomarkers obtained by serial

assays. Biofluid acquisition is complete, and projects are ongoing. He is also the site PI of a DNA banking study in

collaboration with investigators from the Mayo Clinic Jacksonville. He is a site Co-PI in a study of mexiletine in

ALS and the site PI in another biomarker study with deep phenotyping and comprehensive

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evaluation of the disease course including measures such as transcranial magnetic stimulation and motor unit number

estimation. With ALS investigator Christopher Donnelly, he is developing an institutional DNA and biofluid

repository for ALS research. Along with collaborators from the Brain Institute, he is developing an induced

pluripotent skin stem cell program. Dr. Lacomis continues to collaborate with colleagues from the division of

Rheumatology in studying autoimmune myopathies and serves on the Adjudication Committee for the study of

“Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis” with Chester V. Oddis, Sponsor

Investigator.

Dr. Lacomis also worked with former fellows David Avila and Diana Mnatsakanova on several projects resulting in

a case presentation entitled, “Quadriceps sparing weakness in a young woman”, at the AANEM annual meeting,

an AANEM case report on thoracic outlet syndrome for CME, and book chapters on topics including thoracic outlet

syndrome, GNE myopathy, and the use of diagnostic testing in neuromuscular disease.

Dr. Lacomis held a workshop on “When is Muscle Biopsy Useful in Evaluation and Management of Myopathy?” at

the annual American College of Rheumatology meeting, presented a lecture on “Repetitive Nerve Stimulation in

Neuromuscular Junction Disorders” at the ASET Annual Conference, and lectured on “Electrodiagnostic Approach

to Weakness in the ICU setting,” at the Twenty-sixth Annual Electrodiagnostic Medicine Course, UPMC Health

System.

Dr. Lacomis serves on the Scientific Advisory Committee for the Myasthenia Gravis Foundation of America, and is

on the editorial board of the Journal of Clinical Neuromuscular Diseases. He co-authors a section on “What’s in the

Literature” for each edition of the Journal of Clinical Neuromuscular Disease.

William Musser, MD

Clinical Assistant Professor

Dr. Musser is a Clinical Assistant Professor in the Department of Psychiatry at the University of

Pittsburgh School of Medicine. He teaches neurology to psychiatry residents in their longitudinal

course. He also serves as a consultant in Forensic Neurology cases in Western Pennsylvania.

Araya Puwanant, MD Assistant Professor of Neurology

Dr. Puwanant pursues clinical research focused on myotonic dystrophy, myasthenia gravis, and

neurologic channelopathies. The genetics, pathophysiology, and developing new approaches to

treatment of myotonic dystrophy is her primary area of interest. This includes investigations of

biomarkers as well as optimal outcome measures and clinical trials. She was a past recipient of

the Muscular Dystrophy Association (MDA) Clinical Research Training Grant and was an

investigator for the NIH-funded Wellstone Muscular Dystrophy Cooperative Research Center.

Currently, she is PI on a longitudinal study of Sub-Regional Body Composition and Clinical

Endpoints in Myotonic Dystrophy, funded by the MDA. She serves as a site PI on a PCORI-funded study for

Comparative Effectiveness of Disease-Modifying Treatments for Myasthenia Gravis. Furthermore, she is co-

investigator in ALS DNA and biomarkers study and an open-label clinical trial of intravenous infusion of ATB200

co-administered with oral AT2221 in adult subjects with Pompe Disease. Dr. Puwanant also serves on the Advisory

Committee for the NINDS funded NeuroNEXT Clinical Research Site at the University of Pittsburgh and the

Medical and Scientific Advisory Board of the Myasthenia Gravis Foundation of America (MGFA).

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Dr. Puwanant evaluates patients in the Neuromuscular Clinic and ALS Multidisciplinary Clinic, sponsored by the

MDA, at the Kaufman Medical Building. She provides electromyography (EMG) service at UPMC Presbyterian

and Shadyside and performs single fiber EMG at the Presbyterian EMG Lab. She directs Neuromuscular Clinic and

provides inpatient consultation service at UPMC Shadyside Hospital. The active teaching service also comprises

medical students and residents. In addition, she teaches a didactic course for first year medical students on Muscle

Cellular and Pathologic Basic of Disease and offers multiple lectures in the Neuromuscular Lecture Series for

neurology residents and fellows.

In the coming year, Dr. Puwanant will continue working on her MDA and PCORI funded studies, developing her

clinical research program on myotonic dystrophy, as well as collaborating with other investigators. She will serve

on the Advisory Committees for the NeuroNEXT Clinical Research Site at the University of Pittsburgh and the

MGFA. She is planning to submit the NINDS career development award (K23) in 2018. She will complete and

submit 2 manuscripts related to outcome measures in myotonic dystrophy. In addition, she will continue her clinical

activities as a neuromuscular and EMG specialist at UPMC Presbyterian and Shadyside.

Saša Živković, MD, PhD

Associate Professor of Neurology

In the academic year July 1, 2016 through June 30, 2017, Dr Zivkovic continued his clinical and

research work focusing on amyotrophic lateral sclerosis, peripheral neuropathy and neurologic

complications of organ transplantation.

Dr. Zivkovic specializes in the treatment of patients with neuromuscular disorders and

participates in the work of the MDA Neuromuscular Clinic and MDA-ALS Multidisciplinary

Clinic. He evaluates patients in neuromuscular clinic and performs electrodiagnostic testing at

Presbyterian and UPMC Shadyside hospitals EMG labs and performs approximately 400 EMG

and nerve conduction studies annually. Dr. Zivkovic remains active in clinical research as a member of the North-

Eastern ALS Consortium (NEALS), and Inflammatory Neuropathy Consortium (INC). He is a site investigator on

a multicenter study treatment of familial amyloid neuropathy with patisiran.

As a working group member of Brighton Collaboration (Working groups on vasculitis and vasculitic neuropathy),

he has co-authored four studies studies on association of vaccination with SLE, vasculitis and vasculitic neuropathy

in Vaccine. Drs Zivkovic, Ali and El-Dokla have also contributed a chapter on spinal cord organization to Conn’s

Translational Neuroscience, edited by Dr Michael Conn. In collaboration with Dr Mnatsakanova, Dr Zivkovic has

published a review on iatrogenic amyloid neuropathy after domino liver transplantation in World Journal of

Hepatology. In collaboration with Drs Gonzalez and Puwanant, he co-authored a manuscript on myasthenia gravis

triggered by immune checkpoint inhibitors in Neuromuscular Disorder. He also continued his clinical research on

the evaluation of neuromuscular function and peripheral neuropathy in the elderly in collaboration with Dr. Else

Strotmeyer, Graduate School of Public Health which resulted in 2 publications.

Dr Zivkovic actively participates in the education of medical students at the University of Pittsburgh, and teaches in

the course Neuroscience and Clinical Neuroscience Clerkship. He has also been teaching neurology and PM&R

residents and clinical neurophysiology fellows in EMG lab, outpatient clinics and inpatient neurology service at

UPMC Presbyterian, and has received the award for Excellence in Clinical Teaching in Neurology residency

program at UPMC. Dr Zivkovic was selected again by his peers as one of Best Doctors in America (Best Doctors,

Inc.). He serves as an editorial advisory board member for World Journal of Hepatology. He also served as an ad

hoc reviewer for journals Muscle and Nerve, Neurology, Transplantation and Transplantation International.

In academic year 2017-2018, Dr. Zivkovic will participate in clinical treatment trials of ALS at UPMC with Dr.

David Lacomis, and will continue clinical research on peripheral neuropathy, and on decline of peripheral nerve

function in elderly. He will serve as site PI for Pittsburgh site of multicenter study on treatment of ALS with

mexiletine and as site PI for Pittsburgh site of multicenter study on treatment of familial amyloid neuropathy with

patisiran. He will also continue clinical research on inflammatory neuropathies and neurologic complications of

organ transplantation.

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Neuro-Oncology

Frank S. Lieberman, MD

Professor of Neurology and Medical Oncology

Director Adult Neuro-Oncology Program UMPC Cancer Center

Dr. Lieberman is director of the adult neuro-oncology program at UPMC Cancer Centers. His

clinical and research efforts encompassed both the treatment of primary CNS tumors and the

neurological complications of cancer. Brain tumor translational investigations focus on the

application of molecular genetic techniques and functional imaging techniques to develop

strategies for individually optimized molecularly targeted treatment of patients with malignant

gliomas, the most common brain tumors in adults.

Dr. Lieberman serves as institutional principal investigator for UPMC in the Adult Brain Tumor Consortium He is

the institutional representative for CNS tumor committees for the NRG, and ECOG-ACRIN oncology clinical trials

consortia. He serves on the Experimental Imaging and Biomarkers committees for ECOG-ACRIN and is the

former chair of the Clinical Trials Design and Development committee for the Quantitative Imaging Network.

Dr. Lieberman is a member of the phase 1 and phase 2 centers in UPMC Cancer Center and one of the faculty

directing institutional participation in the NCI Experimental Therapeutics National Clinical Trials Network.

In collaboration with Jan Drappatz (co-director Neurooncology Program), Ron Hamilton, and Marina Nikaforovna,

Dr. Lieberman is applying Next Generation Sequencing techniques to the development of individualized molecular

therapies for patients with malignant gliomas. UPMC is one of an elite group of cancer centers with CLIA approved

NGS for use in patients undergoing resection for cancer. Drs. Lieberman and Drappatz are the neurooncology

program investigators in UPCI’s molecular pathology database program in which patients whose tumors are

analyzed by NGS participate in a database associated with the UPCI Phase 1 Trials Center. This allows for

identification of potential subjects for molecularly targeted therapeutic clinical trials across tumor types.

Dr. Lieberman has a national leadership role in the development of vaccines for treatment of gliomas. In

collaboration with Dr. Hideho Okada, Dr. Lieberman served as principal investigator for one of the first dendritic

cell vaccine trials for low grade gliomas and coinvestigator for similar trials in high grade gliomas. Despite Dr.

Okada’s relocation to University of California, San Francisco, these collaborations have continued, and the arrival

of Dr. Gary Kohenbash in January 2017 begins a new collaboration testing immunotherapeutic strategies for patients

with glioblastoma.

Dr. Lieberman is also collaborating with Dr. Sameer Agnahotri, recruited in October, 2016, to expand the molecular

genetics program begun in collaboration with Dr. Nikaforovna to include intracranial mouse models of glioblastoma

and medulloblastoma. Dr. Agnahotri’s will be using these models to test candidate molecularly targeted therapeutic

agents in preclinical studies to optimize the choice of agents for human clinical trials.

Dr. Lieberman Previously served as the chairperson of the Clinical Trials Design working group for the Quantitative

Imaging Network and continues collaborations with Dr. James Mountz in the development of novel PET tracers for

assessing tumor response in clinical trials for glioblastoma. In collaboration with Dr. Mountz, Dr. Kohenbash, Dr.

Ashok Panigrahy, and Dr. Carolyn Anderson, Dr. Lieberman is exploring novel techniques for monitoring delivery

of effector T cells and tumor response in clinical trials of Chimeric Antigen Recptor T Cells.

Dr. Lieberman continues to collaborate in projects, led by Paula Sherwood, addressing caregiver stress in families

of patients with primary brain tumors.

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Dr. Lieberman directs the clinical Neuro-Oncology program for UPMC Hillman Cancer Center, is director of the

neuro-oncology rotation at UPMC Hillman-Shadyside for neurology residents and fellows and is an attending for

Neurology house staff morning report. He provides neuro-oncology consultation service for UPMC Presbyterian,

Magee, and Shadyside hospitals. He directs the Neuro-Oncology Tumor Board; a weekly CME category 1 approved

academic teaching case management conference and a monthly Neuro-Oncology Tumor Board conference at UPMC

Shadyside which is a case presentation and topic review format for the oncology community. He also serves on the

bioethics committee at UPMC Shadyside.

Dr. Lieberman is a member of the Society for Neuro-Oncology and the Neurooncology Section of the American

Academy of Neurology. He currently serves on the committee administering the subspecialty neurooncology board

examination for the United Council of Neurologic Specialities. He is a member of the American Association of

Cancer Researchers and American Society of Clinical Oncology.

Dr. Lieberman has a long interested in the intersection between religion and medical practice, and the application of

the principles of Jewish religious law to clinical bioethics. He is a member of a working group of faculty in the

University of Pittsburgh School Of Medicine, the law school, and the Religious Studies Program, aspiring to develop

a program for religion and medicine at University of Pittsburgh. He is the director of a new clinical case conference

addressing how religious faith affects the care of patients form both patient and physician perspectives.

Jan Drappatz, MD

Associate Professor of Neurology

Associate Director, Adult Neurooncology Program

As a board- certified neurologist specializing in the field of neuro-oncology, my primary areas

of research involve the development of novel agents for the treatment of glioblastoma, central

nervous system lymphoma, and other primary and metastatic brain tumors. I have served as the

principal investigator of numerous clinical trials to identify effective therapies for patients with

brain tumors and other neurological ailments associated with cancer.

Research Division

Guodong Cao, PhD

Associate Professor of Neurology

Dr. Cao and his group continue his projects to investigate the effect of nicotinamide

phosphoribosyl transferase (NAMPT) on white matter restoration and neurovascular remodeling

after brain ischemia funded by NIH and the Department of Veteran Affair. Recently he

established a novel approach to convert reactive astrocytes surrounding infarct core into

oligodendrocytes in situ in brain ischemia. This approach will not only convert detrimental

astrocytes into beneficial oligodendrocytes, which can restore damaged white matter, but also

prevent the formation of astrocytic scar. This novel finding has been funded by the Department of Veteran Affair.

Dr. Cao is also investigating whether reprogrammed oligodendrocytes will enhance cognitive functional

improvement following brain ischemia as well as white matter and neurological restoration in traumatic brain injury.

Dr. Cao has served on the Editorial Board for 16 journals.

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Jun Chen, MD

Professor of Neurology and Pharmacology

Dr. Chen’s laboratory studies the cellular and molecular mechanisms underlying neuronal

degeneration and brain repair in models of cerebral ischemia or traumatic brain injury (TBI). A

number of publications from this lab have had major influence on the field and are among the

most cited manuscripts in journals. Having been engaged in the field for 25 years, the most

significant contributions from Dr. Chen’s laboratory include the findings on: 1) the role of

mitochondrial signaling pathways in neuronal death and brain dysfunction in various neuronal

injury models; 2) the role of oxidative DNA damage and repair in ischemic brain injury and

recovery; 3) the role of microglial/macrophage polarization as a double-edged sword in ischemic brain injury and

repair; and 4) the role of microglia and oligodendrocytes in white matter repair after stroke or TBI. The current focus

of Dr. Chen’s laboratory is three-fold. The first focus is to determine the role & mechanism of endothelial

dysfunction and immunological responses (microglial/macrophage polarization, infiltration and reprogramming of

circulation immune cells) in the pathogenesis of blood brain barrier damage, neurovascular dysfunction and

neurological deficits after stroke. The second focus is to investigate how white matter injury and repair may

contribute to long term neurological deficits & recovery after stroke or TBI, with particular focus on demyelination

and remyelination mechanisms. The third focus is to extend the long term research on the base excision repair (BER)

pathway of DNA repair into an exciting new era, i.e. studying the role of DNA repair (through the newly discovered

long-patch BER pathway) in functional recovery after stroke.

Dr. Chen has actively participated in teaching graduate students. He is a training faculty member of the CNUP and

MD/PhD programs and a dissertation advisor for graduate students. Dr. Chen teaches two different graduate study

courses (Cell and Molecular Neurobiology MSNBIO 2100 and Neuropharmacology MSMPHL 3375). He has been

a PhD advisor of the neuroscience program at Fudan University since 2004.

Dr. Chen has continued to serve at national and international levels. He is a member of study sections NIH, AHA,

and VA, and also serves as a reviewer or consul member for various international science foundations. He is the

current Treasurer of the International Society of Cerebral Blood Flow and Metabolism. He serves as an editorial

board member for 13 professional journals, including Journal of Neuroscience, Journal of Cerebral Blood Flow and

Metabolism, Stroke, Neurobiology of Disease, and Progress in Neurobiology, etc.

Paula R. Clemens, MD

Professor of Neurology

Chief, Division of Veterans Affairs

During the academic year from July 1, 2016 to June 30, 2017, Dr. Clemens provided leadership

for the Neurology Service at the VA Pittsburgh Healthcare System (VAPHS) and served as a

Vice Chair for the Department of Neurology. She directed an out-patient and consultation service

with 9 part-or full-time neurologists and 3 neurology resident physician positions at VAPHS.

The active teaching service also comprised third and fourth year medical students, geriatrics

fellows and geriatric psychiatry fellows during the course of the year. More information on the

VAPHS Neurology Service is included elsewhere in this annual report. Dr. Clemens chairs the Institutional Biosafety

Committee at VAPHS.

Dr. Clemens pursues basic and clinical research focused on discovering and improving treatment of skeletal muscle

diseases. Her basic research projects include characterization of the molecular pathology of mouse models of muscle

wasting in muscular dystrophy, muscle injury, idiopathic inflammatory myopathy and nerve injury. The Clemens

Laboratory explores the modulation of NF-B signaling pathways for amelioration of the skeletal muscle phenotype

and modulation of immunity in these disorders. Human clinical research studies directed by Dr.

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Clemens include leadership as the Medical Director of a multi-center academic trials group devoted to the study of

therapeutic agents for patients with muscular dystrophy, the Cooperative International Neuromuscular Research

Group (CINRG). Dr. Clemens serves on the Data Safety Monitoring Board for a study sponsored by Pfizer, Inc. and

2 studies sponsored by the NIH.

Dr. Clemens co-directs an NIAMS-funded P50 Center of Research Translation of Systemic Exon Skipping for

Muscular Dystrophy and an NINDS-funded NeuroNEXT clinical study site. NeuroNEXT is a nationwide clinical

trials network established to conduct neuroscience clinical trials. The University of Pittsburgh is an active enrolling

site in ongoing NeuroNEXT trials. She also leads a Department of Defense-funded clinical treatment trial in

muscular dystrophy. Dr. Clemens is the chair for a multi-center DMD treatment trial for a new dissociative steroid

that is funded in part by an NIH Small Business Innovations Research grant as well as other sources. Furthermore,

Dr. Clemens is the chair for a multi-center DMD treatment trial for exon 53 skipping therapy, sponsored by NS

Pharma, Inc.

Dr. Clemens leads the clinical and research activities in late-onset Pompe disease at the University of Pittsburgh.

She manages lumizyme infusion therapy for patients with late-onset Pompe disease. She is the University of

Pittsburgh site investigator for the Pompe Registry and also serves on the Pompe Registry Board of Advisors. She

is site PI for an industry-sponsored treatment trial in adult-onset Pompe disease.

Dr. Clemens precepts third and fourth year medical students rotating on the VAPHS Neurology Service. She is a

career advisor for students in the Medical Scientist Training Program (MSTP) and the Physician Scientist Training

Program (PSTP).

Dr. Clemens is a member of a steering group organized by the Centers for Disease Control to update the Care

Considerations for DMD that will be published during the coming year, and she also participated as a working group

member to prepare a comprehensive document of ‘Management of Cardiac Impairment in Neuromuscular Disease’

for the American Heart Association.

In the coming year, Dr. Clemens will continue her basic and clinical research program in the treatment of

neuromuscular disease. She will continue her clinical activities as a neuromuscular specialist, her involvement in

the neurology residency clinical training program, and her leadership of the neurology service at VAPHS.

Steven H. Graham, MD, PhD

Connolly Family Chair in the Stroke Institute

Professor and Vice-chairman for Research

Director, Geriatric Research Educational and Clinical Center

Associate Chief of Staff for Research, VA

Dr. Graham’s research focuses on the mechanisms by which neurons die after stroke and brain

trauma. Ongoing research projects address the role of the the protein, UCH-L1 also known as

Parkin 5 in stroke, traumatic brain injury and neurodegeneration. UCHL1 activity is required

to maintain axonal transport and synaptic function. New findings this year have shown that

axonal injury in mice with traumatic brain injury may be reduced by treatment with a novel protein fusing UCHL1

and elements of the prothrombin domain of the HIV capsid protein TAT. This novel protein readily enters the brain

and neurons when given systemically. These and other findings lead to the funding of new R01 award from NIH

NINDS to explore the role of UCHL1 in the pathogenesis and treatment of TBI.

Dr. Graham is the Director of the Geriatric Research, Educational and Clinical Center (GRECC) at the VA. The

GRECC is a multidepartmental center that aims to develop new treatments, educate providers and students and pilot

new methods of delivering clinical care for elderly Veterans. The research foci of the GRECC includes stroke,

traumatic brain injury, Alzheimer’s disease, communication disorders, and cardiac rehabilitation. Dr.

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Graham is also serving as Associate Chief of Staff for Research at the VA. As Vice-chair for Research of the

Department of Neurology he oversees the rapidly growing research program of the Department. Dr. Graham

precepts medical students and residents on the inpatient services at the VA. He is also a staff neurologist at the VA

with a special interest in stroke and dementia.

Dr. Graham will continue his ongoing NIH-funded studies regarding the mechanisms by which UCHL1 restores

axonal function in stroke and TBI. As GRECC Director, he plans to recruit new faculty and further develop its

research program in cerebrovascular disease and geriatrics.

Teresa G. Hastings, PhD

Associate Professor of Neurology

Pittsburgh Institute for Neurodegenerative Diseases

Dr. Hastings is a member of the Pittsburgh Institute for Neurodegenerative Diseases (PIND).

Her research examines the role of dopamine oxidation, ROS formation, protein modification,

and mitochondrial dysfunction in the selective vulnerability of dopaminergic neurons. The goal

of her work is to identify therapeutic agents to prevent neurodegeneration associated with

Parkinson’s disease, drugs of abuse, and aging in general. Using proteomic techniques, Dr.

Hastings’ laboratory is identifying mitochondrial and intracellular proteins that show changes

in expression, oxidative modification, or aggregation following exposure to dopamine and other oxidative stressors.

This is an important step in linking alterations in critical protein structure and function to the death of the neuron.

New projects in the lab include examining the neuroprotective effect of dietary selenium and the role of

mitochondrial selenoproteins in preventing neurotoxicity.

Dr. Hastings is active in the Center for Neuroscience (CNUP) Graduate Program. This year she served on 8 graduate

student committees. She is the Director of and a lecturer in Block 1 of the CNUP graduate course Cellular and

Molecular Neurobiology. She also lectures in other courses. This year, Dr. Hastings is mentoring two postdoctoral

fellows, one graduate student, and one undergraduate student in the laboratory, and serves as the career advisor for

four MSTP students. She serves as training faculty on two institutional training grants including “NIH Medical

Scientist Training Program (R. Steinman, Director) and "NIH Predoctoral Training in Basic Neuroscience" (A.F.

Sved, Director). Dr. Hastings is also the Co-Director of the Honors College Health Sciences Undergraduate Summer

Research Program.

Dr. Hastings is a member of the MSTP/CNUP Admissions/Recruitment Committee, the Department of Neurology

Promotions Committee and the Tenure Stream Review Committee and the Executive Committee for the Pittsburgh

Institute for Neurodegenerative Diseases (PIND). She is also a member of the Steering Committee for the NIH

Institutional Predoctoral Training Grant, the Medical Scientist Training Program (MSTP) Steering Committee, the

Competitive Medical Research Fund (CMRF) Standing Review Committee, and the University Council on Graduate

Study. This year, Dr. Hastings was named as an Honors College Faculty Fellow with the University of Pittsburgh

Honors College.

Xiaoming Hu, MD

Research Assistant Professor of Neurology

Dr. Hu’s core research interests are to explore the immune-related mechanisms of ischemic

stroke and neurodegenerations, and to develop immunotherapies to treat these conditions. Last

year, her main research directions were on 1) exploring the protective effect of regulatory T

cells (Tregs) in models of stroke, and 2) exploring “recovery-enhancing drugs” that not only

promote gray matter integrity but also enhance white matter recovery after stroke.3)

Characterize microglia/macrophage polarization after stroke and identify the molecular switches

in microglia/macrophages that control phenotypic change.

65

Milos D. Ikonomovic, MD

Associate Professor of Neurology

Over the past academic year, Dr Ikonomovic and his research team have made several major

advances in studies examining the pathobiology of two inter-related neurodegenerative

conditions, chronic traumatic brain injury (TBI) and Alzheimer’s disease (AD). Dr. Ikonomovic

received new R01 award to design, produce, and characterize novel radioligands for labeling

toxic deposits of amyloid-beta (Aβ) peptide in brain blood vessels, for use in future PET imaging

studies in living AD patients. He is also Principal Investigator on a project funded by the

Department of Veterans Affairs’ RR&D, to examine AD related pathology changes during

chronic periods after blast injury in transgenic PSEN1dE9 mice and how these changes are associated with axonal

pathology imaged in vivo, a collaborative project with investigators from VA Iowa City Medical Center. Dr.

Ikonomovic is also Principal Investigator on a VA MERIT Review Award “Novel multifunctional rehabilitative

therapy to reduce Alzheimer pathology after TBI”. He also leads a project within the NIA-funded PPG

“Neurobiology of Mild Cognitive Impairment” (PI Dr. Elliott Mufson, Barrow Neurological Institute), examining

alterations in Aβ metabolism, synaptic integrity and cholinergic function in mild cognitive impairment (MCI) and

early AD. New study from Dr. Ikonomovic’s laboratory demonstrated that brain amyloid deposits detectable using

PET ligand [C-11]PiB are associated with loss of dendritic spines in the precuneus neocortex, possibly reflecting

synaptic dysfunction and cognitive impairment during the progression of PET-detectable pathology (findings were

presented at the ADPD 2017 conference). Dr. Ikonomovic also leads a project within the NIH-funded PPG “In Vivo

PET Amyloid Imaging: Normals, MCI, and Dementia” (PI Dr. William Klunk, Department of Psychiatry). On this

project, Dr. Ikonomovic’s laboratory characterized neuropathological substrates for binding of PiB and a novel tau

PET ligand AV-1451, by conducting postmortem histological and biochemical analyses of Aβ and tau and

correlating this pathology with PET measures recorded in the same subjects antemortem.

Dr. Ikonomovic continued to work as Co-Investigator on several projects, including collaboration with Dr. Robert

Sweet (Department of Psychiatry), examining if changes in cortical soluble Aβ and tau concentrations can

differentiate AD patients with psychoses relative to AD patients without psychoses. Dr. Ikonomovic also

collaborates with Dr. Chester Mathis (Department of Radiology) and Dr. William Klunk (Department of

Psychiatry) on a project funded by the Michael J. Fox Foundation, to design and test novel compounds selective

for alpha-synuclein aggregates. Dr. Ikonomovic is Co-Investigator on several other studies, with Dr. David

Okonkwo (Department of Neurosurgery) on the Department of Defense study to develop an in vivo

neuroimaging biomarker panel for chronic traumatic encephalopathy; with Dr. Ben Handen (Psychiatry) on a

PET, MRI, and plasma biomarker study of adults with Down syndrome; and with Dr. C. Edward Dixon on an

R01 study evaluating alpha-synuclein and synaptic dysfunction after TBI.

During the next academic year, Dr. Ikonomovic will continue to work on his current studies, collaborations, and

several new research investigations. He will continue to train fellows and students in his laboratory. He serves on

the VA Research Scientific Evaluation Committee, and provides consultant services to Neuropathology Core of

the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC) and to GE Healthcare. He also serves

as an associate editor for the journal Cardiovascular Psychiatry and Neurology, and Review Editor for the journal

Neurotrauma. He is a grant reviewer for the Alzheimer Association’s International Research Grant Program and an

ad-hoc grant reviewer for NIH and VA Scientific Review groups.

Hao Liu, MD, PhD

Research Assistant Professor

Dr. Liu’s research interest focuses on the molecular mechanisms underlying neuronal cell injury

after stroke and brain trauma and potential novel therapeutic approaches. Specifically, Dr. Liu

and his colleagues, supervised by Dr. Steven H. Graham, are studying the role of cyclopentenone

prostaglandins (CyPGs) and some important enzymatic proteins in post-

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ischemic and post-traumatic neuronal injury. Their work has shown that the generation of CyPGs is highly increased

after stroke and trauma. This excessive CyPG production induces neuronal cell death by adducting and unfolding

many essential proteins. One of the CyPGs’ targets is UCH-L1, which is an abundant protein expressed strictly

within the neuronal system and it’s mutation and modifications have been linked to many neurodegenerative diseases

such as Parkinson’s disease. Dr. Liu’s other ongoing projects address the role of UCH-L1 in neuronal cell survival

and axonal repair under a variety of pathological conditions, including hypoxia and trauma. To facilitate their

research, two knock-in transgenic mice lines carrying mutations in UCH-L1 gene have been made. A TAT-fusion

protein has been generated to delivery UCH-L1 into the brain. Recently, their research has demonstrated that a

specific point mutation in UCH-L1 can significantly attenuate stroke- or trauma- induced brain damage. In addition,

in vivo delivery of TAT-UCH-L1 protein is protective against stroke- and trauma- induced neuronal injury. Dr. Liu

is a member of Society for Neurosciences (SFN) and International Society for Cerebral Blood Flow and Metabolism

(ISCBFM), and he is an ad-hoc reviewer for some journals including APMIS, Cellular Physiology and Biochemistry,

Molecular Medicine Reports, and he also served as a reviewer for the international academic conference: Brain &

BrainPET -2017.

Ruth AnnStetler, PhD

Assistant Professor of Neurology

Dr. Stetler’s research has been focused on mechanisms supporting tissue protection against and

cellular recovery from cerebral ischemia. She has been actively pursuing the influence of DNA

repair in white matter recovery following ischemic injury. In addition, several other projects

are under development, including the role of mitochondrial dynamics in ischemic

neuroprotection. Major publications include the following:

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics

GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter and neurological function

after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567, doi:10.1073/pnas1606226113

Stetler RA, Leak RK, Jing Z, Hu X, Gao Y, Cao G, Chen J. The interplay between white matter, mitochondria and

neuroprotection. In: Vascular Mechanisms in CNS Trauma. Eds: Lo EH, Lok JM and Whalen M, Springer: New

York. 2014;539-554.

Stetler RA, Leak RK, Gan Y, Li P, Hu X, Jing Z, Chen J, Zigmond MJ, Gao Y. Preconditioning provides

neuroprotection in models of CNS disease: Paradigms and clinical significance. Progress in Neurobiology,

2014;114:58-83.

Stetler RA, Leak RK, Gao Y, Chen J. The dynamics of the mitochondrial organelle as a potential therapeutic target.

J Cereb Blood Flow Metab. 2013;33:22-32.

Stetler RA, Leak RK, Yin W, Zhang L, Wang S, Gao Y, Chen J. Mitochondrial biogenesis contributes to ischemic

neuroprotection afforded by LPS preconditioning. J Neurochem. 2012;123(Suppl. 2):125-137.

Stetler RA, Gao Y, Zhang L, Weng Z, Zhang F, Hu X, Wang S, Vosler, Cao G, Sun D, Graham SH, Chen J.

Phosphorylation of HS27 by Protein Kinase D is essential for mediating neuroprotection against ischemic neuronal

injury. J Neurosci. 2012;32(8):2667-2682.

Stetler RA, Gan Y, Zhang W, Liou AK, Gao Y, Cao G, Chen J. Heat shock proteins: Cellular and molecular

mechanisms in the CNS. Progress in Neurobiology, 2010;92(2):184-211.

Stetler RA, Gao Y, Zukin RS, Vosler PS, Zhang L, Zhang F, Cao G, Bennett MVL, Chen J. The

apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. PNAS. 2010;107(7):3204-3209.

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Dandan Sun, MD, PhD

Professor of Neurology

Dr. Sun’s laboratory is interested in understanding the role of ion transporter proteins (Na+-K+-

Cl- cotransporter, Na+/H+ exchanger, and Na+/Ca2+ exchangers) in ionic dysregulation and

neurodegeneration associated with stroke and hypoxic ischemic encephalopathy. In particular,

we study how changes of cytosolic ionic concentrations (Na+, H+, Ca2+) as well as organelle

Ca2+ (ER and mitochondria) cause nerve cell death and proinflammatory responses in ischemic

brains. With respect to Glioblastoma multiforme (GBM) brain tumor, we study how the ion

cotransporters function in regulating tumor tissue microenvironment and cell volume. These proteins are targets for

therapeutic intervention.

During the academic year July 2016 – June 2017, Dr. Sun’s laboratory made major research progress and published

the following scientific papers:

1. Y. Yin, G. Sun, E. Li, K. Kiselyov, Dandan Sun. ER stress and impaired autophagy flux in neuronal

degeneration and brain injury. Ageing Research Reviews 2016, pii: S1568-1637(16)30169-6. doi:

10.1016/j.arr.2016.08.008. 2. J. Zhang, G. Gao, G. Begum, J. Wang, A. R. Khanna, B. E. Shmukler, G. Daubner, P.Heros, P. Davies,

J. Varghese, M. I. H. Bhuiyan, J.J Duan, J. Zhang, D. Duran, S. L. Alper, Dandan Sun, S. J. Elledge,

D. R. Alessi, K. T. Kahle. Functional kinomics establishes a critical node of volume-sensitive cation-

Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 2016, 6:35986. doi:

10.1038/srep35986

3. M. I. H Bhuiyan, S. Song, H. Yuan, G. Begum, J. Kofler, K. T Kahle, S-S Yang, S-H Lin, S. L Alper,

A. R Subramanya and Dandan Sun. WNK-Cab39-NKCC1 signaling increases the susceptibility to

ischemic brain damage in hypertensive rats. JCBFM. 2016, pii: 0271678X16675368. NIHMS 840430 4. Y. Yin, E. Li, G. Sun, H. Q. Yan, L. M. Foley, L. A. Andrzejczuk, I. Y. Attarwala, T. K. Hitchens, K.

Kiselyov, C. E. Dixon, Dandan Sun. Effects of DHA on hippocampal autophagy and lysosome

function after traumatic brain injury. Mol Neurobiol. 2017. NIHMS 864940

Kejie Yin, MD, PhD

Assistant Professor of Neurology

Dr. Kejie Yin has been an Assistant Professor in the Department of Neurology since September

2015. Dr. Kejie Yin earned his MD from Yangzhou University Medical College, MS in

Neuroanatomy from Nanjing Medical University, and PhD in Neurobiology from Shanghai

Medical University. After completing his postdoctoral training at College of Medicine University

of Saskatchewan in Canada, Dr Yin joined in the Department of Neurology in the Washington

University School of Medicine as a Research Associate and a Research Instructor. Dr. Yin was a

Research Assistant Professor in the University of Michigan before his recruitment to the University of Pittsburgh

School of Medicine.

As a principal investigator in the Pittsburgh Institute for Brain Disorders and Recovery (PIBDR), Dr. Yin’s research

interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural

dysfunction after ischemic stroke, traumatic brain injury and Alzheimer's disease by using state-of-the-art cell

biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal

approaches. His major research focuses on investigating the functional importance and molecular mechanisms of

non-coding RNAs (microRNAs, long non-coding RNAs) and Krüppel-like transcription factors in the

cerebrovascular endothelial pathophysiology (BBB disruption, Vascular and parenchymal inflammation,

Angiogenesis) following ischemic stroke and traumatic brain injury. Currently Dr. Yin’s research is supported by

two NIH R01 and one R21 grants.

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Dr. Yin teaches graduate students and postdoctoral fellows in the PIBDR and CNUP at the University of Pittsburgh

Medical Center. He also gives lectures at the departmental lecture or seminar series. He performs laboratory-based

research tutoring and teaching to Post-doctoral fellows, graduate students, and clinical fellows in his laboratory as

well.

In the coming year, Dr. Yin will continue to work on his NIH-funded basic and translational research programs

investigating mechanisms of neuroprotection and repair in the setting of stroke.

Feng Zhang, MD, PhD

Assistant Professor of Neurology

Pittsburgh Institute of Brain Disorders and Recovery

Dr. Zhang joined the faculty of Neurology in November of 2009. His research interest

focuses on experimental cerebral ischemia and neuroprotection using small molecular

proteins, chemical compounds or ischemic preconditioning. His projects include the

neuroprotective effects of synthetic triterpenoids, hypothermia, ischemic preconditioning

and omega-3 fatty acids, which are rich in fish oil. He is also interested in the mechanisms

responsible for the protection of these approaches, including various signaling pathways and antioxidative

enzymes. His recent researches focus on Nrf2 pathway in neuroprotection mediated ischemic preconditioning,

which is supported by a NIH R01 grant. Dr. Zhang serves as an editorial board member for the NS &

Neurological Disorders‐Drug Targets and Austin Journal of Cerebrovascular Disease & Stroke, and as ad-hoc

referee for a number of journals, including Neurobiology of Disease, CNS Neuroscience & Therapeutics, Brain

Research, Translational Stroke Research, Plos One, Journal of Visualized Experiments, Molecular

Neurobiology, Pharmacology, Neuroscience and Scientific Reports.

Michael Zigmond, PhD

Professor of Neurology

Pittsburgh Institute for Neurodegenerative Diseases

Over the past year Dr. Zigmond and his research team have continued their studies of cellular

and animal models to examine Parkinson's disease (PD) and aging. A major focus of the lab is

finding ways to arrest the motor decline associated with PD. They hypothesize that a loss of

trophic factor support is involved in these motor deficits and that this leads to a decline in the

activation of survival kinases such as ERK1/2 and Akt and a consequent deterioration of

dopaminergic signaling. Their evidence indicates that the expression of neurotrophic factors,

including GDNF and BDNF, can be enhanced by physical exercise and that this in turn can stimulate kinases and

reduces the vulnerability of dopamine to neurotoxins and to the effects of aging.

The Zigmond lab is also interested in the impact of stressors on the vulnerability of dopamine neurons to subsequent

cellular stress. These studies have involved both in vivo and in vitro models. For example, they have found in

preliminary studies that several stressors – including maternal separation, traumatic brain injury, and restraint stress

– can make rats more vulnerable to 6-hydroxydopamine. On the other hand, exposure to a subtoxic concentration of

6-hydroxydopamine, methamphetamine, or MG132 (an inhibitor of proteasomal function) greatly

reduced the vulnerability of dopaminergic cells to a subsequent challenge; a phenomenon termed “preconditioning.”

Indeed, exercise may reflect a type of in vivo preconditioning by virtue of the mild increase in cellular stress that it

provokes.

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Vascular Neurology

Tudor Jovin, MD

Associate Professor of Neurology and Neurosurgery

Division Chief, Vascular Neurology

Director, UPMC Center for Neuroendovascular Therapy

Director, UPMC Stroke Institute

Chair, UPMC Stroke System of Care

Dr. Jovin is an expert in interventional and non-interventional treatments for the entire spectrum

of cerebrovascular disorders, including ischemic hemorrhagic stroke, and is the leader of UPMC

Stroke Institute, one of the highest volume centers in the country.

He serves as principal investigator for the ongoing REVASCAT study, a randomized trial in Spain of endovascular

therapy versus medical therapy for stroke due to large artery occlusion within 8 hours, as well as principal

investigator for DAWN, a multicenter, international, randomized trial of endovascular therapy versus medical

therapy in the beyond 8-hour time window. He is a member of the executive/steering committee for several

multicenter national and international trials, and he is site principal investigator/co-investigator for several local or

multi-center clinical trials. He has published more than 150 articles in peer-reviewed journals or book chapters.

As the former UPMC Stroke Fellowship Program Director and UPMC Neurointerventional Fellowship Program

Director, positions he has held for over five years, Dr. Jovin has significant experience in mentoring young

neurologists or neurosurgeons who, in addition to acquiring the necessary clinical and procedural skills for

successful clinical practice, have authored numerous publications in leading peer-reviewed cerebrovascular disease

journals.

Dr. Jovin serves as president of the Society of Vascular and Interventional Neurology and serves on several other

committees or boards of national and international societies (American Academy of Neurology, American Society

of Neuroimaging, Society of Neurointerventional Surgery) and editorial boards of medical journals within his area

of expertise (Stroke, Journal of Neuroimaging). Dr. Jovin’s clinical and research activities are focused on the care

of patients with cerebrovascular disorders. Investigator/Co-investigator on several local or multi-center clinical

trials, he brings the experience to successfully design and carry out clinical studies. As the former UPMC Stroke

Fellowship Program Director and UPMC Neurointerventional Fellowship Program Director, positions he has held

for over 5 years Dr. Jovin has significant experience in mentoring young neurologists or neurosurgeons who in

addition to acquiring the necessary clinical and procedural skills for successful clinical practice have authored

numerous publications in leading peer-reviewed cerebrovascular disease journals.

Maxim Hammer, MD

Associate Professor of Neurology

Vice-Chairman, Clinical Affairs

Director, Inpatient Neurology

Director, Vascular Neurology Fellowship Program

Director, Neurosonology Laboratory

UPMC Presbyterian Hospital

Staff Stroke Neurologist, The Stroke Institute

UPMC Mercy Hospital

Director, Stroke Services

A graduate of Dartmouth College, Dr. Hammer did his Neurology Residency at the Cleveland Clinic, then his

Vascular Neurology Fellowship at UPMC under Dr. James Gebel. He joined the Neurology faculty in 2003. He is

Board certified in Neurology as well as in Vascular Neurology and is interested in clinical practice, clinical research

and teaching.

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Dr. Hammer has been the Director of Stroke services at UPMC Mercy Hospital since 2008, where he has overseen

the development of a busy inpatient stroke practice. The Stroke Program at Mercy has been given multiple awards

by the American Heart Association during the time of his directorship. He has also has helped develop the

department’s Stroke Clinic at UPMC Mercy. He founded and directs the department’s Neurosonology lab, which

provides outpatient services as well as inpatient services to UPMC Mercy and Presbyterian hospitals, using carotid

duplex and transcranial ultrasonography. Dr. Hammer continues to attend hospital service at UPMC Presbyterian,

Shadyside and Mercy, and contributes to providing telemedicine stroke services to multiple hospitals in and out of

the UPMC system.

Dr. Hammer’s research interests lie predominantly in novel approaches to acute stroke, and he has contributed to

national clinical research studies including SENTIS (Safety and Efficacy of NeuroFlo Technology for Ischemic

Stroke), for example, and has participated in multiple other industry sponsored as well as NIH sponsored clinical

trials. However, Dr. Hammer prefers mentoring medical students in their research endeavors, usually focused on

quality improvement, and many of these projects have blossomed into significant publications.

Dr. Hammer has been involved with teaching since joining the department, beginning with didactic and bedside

teaching of residents and fellows. Since 2009, he has been involved with teaching at the Medical School’s

Neuroscience course both as lecturer and preceptor and in 2013 was asked to join the course’s curriculum

development committee. Dr. Hammer has been part of the Neurology Residency Curriculum Development

committee since 2006. He has been the director of the department’s Vascular Neurology Fellowship program since

2012, having mentored three fellows per year since that time.

Dr. Hammer assumed administrational roles within the Department, starting in 2014, when he became the Director

of Inpatient Services, involving oversight of inpatient neurologic care at many UPMC hospitals. In 2015, he became

Vice Chairman of Clinical Affairs for the Department, and now oversees all aspects of inpatient and outpatient

clinical care. In 2015-16, he completed the Marshall W. Webster Physician Leadership Training Program and has

been accepted into the first class of the newly-created Katz-UPMC Executive MBA in Healthcare program.

Ashutosh Jadhav, MD, PhD

Assistant Professor of Neurology

UPMC Stroke Institute

UPMC Center for Neuro-endovascular Therapy

Director, Stroke Services, UPMC, Shadyside Campus and Mercy Campus

Associate Director, Vascular Neurology Fellowship Program

Director, StrokeNet Fellowship Program

Dr. Jadhav is Assistant Professor of Neurology and Neurosurgery. He completed his

undergraduate and graduate studies at Harvard University after which he completed his medical studies at Harvard

Medical School. He is dually trained in the medical and endovascular care of stroke patients. He is a member of

the UPMC Stroke Institute and Center for Neuro-endovascular Therapy where he has performed over 2000 neuro-

interventional procedures. He also services as director of stroke services at UPMC-Shadyside campus. He actively

participates in resident and fellow education with weekly lectures. His teaching efforts have been recognized twice

with the Neurology resident Faculty Teaching Award. Additionally, he services on the curriculum committee for

the Neurology residency and Vascular Neurology fellowship. He actively participates in nursing and EMS education

with monthly lectures. He serves on the UPMC Stroke Institute CME course planning committee. Dr. Jadhav is an

active member of several societies, including the American Stroke Association where he serves as an abstract grader

for the annual International Stroke Conference. As a member of the Society of

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Vascular and Interventional Neurology, Dr. Jadhav is a board member and an associate editor of the quarterly

newsletter. Additionally, Dr. Jadhav serves as a reviewer for several journals including: Neurology, Journal of

Neuro-Interventional Neurosurgery, Journal of Neuroimaging. He has published over 70 articles in peer-reviewed

journals or book chapters. He serves as a sub-investigator on over a dozen clinical trials and serves as local principal

investigator on six global clinical trials (ARISE II, Atlas, DAWN, Rhapsody, STRATIS and Trevo Registry). His

research interests focus on the natural history and management of cerebrovascular occlusive disease and

endovascular approaches to acute ischemic stroke.

Name: James R. McLaughlin D.O. FACP, FAAN, FAHA

Clinical Assistant Professor of Neurology

Dr. McLaughlin has been affiliated with the UPMC Neurology Department since October 2006

and a faculty member since January 2016. Completed a general internal medical residence at

Geisinger Medical Center in 1987 and a Neurology residency at St. Louis University in 1990.

He subsequently joined the medical staff at Franklin Regional Medical Center in 1990 and

started a Primary Stroke Care Program in 1995 which has continued to date. He is currently

board certified in general internal medicine, neurology, vascular neurology and clinical

neurophysiology.

Dr. McLaughlin is the medical director for the Primary Stroke Care Program, Clinical Neurophysiology Lab and

Telemedicine services at UPMC Northwest. He practices general neurology as well as subspecialty care in vascular

neurology and clinical neurophysiology for both the inpatient and outpatient department at UPMC Northwest.

During his tenure as medical director of the stroke program it has received JCH certification as a primary stroke care

center and multiple awards from the ASA/AHA for quality of stroke care. Previously a member of the American

Stoke and Heart Association Telemedicine Committee, he continues these efforts locally through UPMC Northwest

telemedicine and active involvement in EMS education and assessment of triage mechanisms in the community.

Dr. McLaughlin is also actively involved in educating nursing, radiology technician and medical students through

attendance at the inpatient bi-weekly multi-disciplinary stroke care meeting and as preceptor for nursing and medical

students in the office setting.

This past year through Dr. McLaughlin’s direction the hospital implemented a tele ophthalmology consult service

utilizing a digital retinography system in conjunction with the University Eye & Ear Institute. This will allow 24/7

availability for ophthalmologic emergencies and effective triage for both adult and pediatric patients.

In the coming year, we will continue to develop the program as described above and plan the development of an

inpatient tele neurology consult and rounding service in conjunction with UPMC Stroke institute and UPMC Hamot

Department of Neurology which will ensure consistent care and appropriate triage of patients in Dr. McLaughlin’s

absence. Through Dr. McLaughlin’s oversight, we are currently proceeding with development of an ICU tele consult

service in conjunction with Dr. Al-Khafaji and the Department of Critical Care Medicine. With Dr. McLaughlin’s

supervision, the Emergency Room EMS representative and an Emergency Room stroke nurse representative are

currently educating local EMS crews and coordinating a follow-up assessment of the deficiencies identified in the

rural community EMS poster presented at the International Stroke Conference 2017.

There is ongoing discussion and planning to ultimately implement a field telemedicine triage plan for stroke patients

regionally.

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Vivek Reddy, MD

Assistant Professor of Neurology

Dr. Reddy is involved in a variety of clinical and educational activities as part of the department

of neurology. His clinical work involves outpatient services, focusing on the continuing care and

evaluation of patients with cerebrovascular disease. He also is very involved in the inpatient

clinical stroke service, focusing on standardization of clinical practice and approach to stroke

care. He has been very involved in the creation and enhancement of

stroke order sets and protocols at UPMC Presbyterian and UPMC Shadyside, which have served

as the basis of order sets for other UPMC hospitals.

In addition to his clinical work, Dr. Reddy is the Chief Medical Information Officer, Physician and Hospital Services.

His role extends across all the UPMC facilities and involves guiding the direction, improving utilization of electronic

medical records to improve quality of care. He has been involved in several implementations of electronic medical

records across the system.

Dr. Reddy provides educational supervision to residents and medical students and gives several lectures to medical

students and residents during the academic year.

Mareclo Rocha, MD, PhD

Assistant Professor of Neurology

Dr. Rocha was awarded an UPP Foundation Research Grant for the study of

mitochondrial based biomarker development in acute strokes due to large vessel

occlusion during the 2016-2017 academic year. This funding has been renewed for the

2017 – 2018. The plan is to generate preliminary data for submission of career

development grants from professional organizations (AHA, AAN), private foundations

(Welcome Borrows Fund) and NIH K-award applications in the upcoming grant

cycles.

Dr. Rocha published two first author articles in the two of the widely-read journals in our field (Rocha M

and Jovin TG, Stroke 2017 and Rocha M et al., Journal of Neurointerventional Surgery, in press).

Dr. Rocha submitted Research Abstract to the International Stroke Conference to take place in January

2018 (AHA): Rocha M, Desai S, Jadhav A and Jovin T. Distribution and Incidence of Fast Versus Slow

Progressors of Infarct Growth in Large Vessel Occlusion Stroke. This abstract will lead to the publication of

another first author publication in the next academic year. It also will form the basis for two other related

clinical research projects which I expect will lead to additional first or last author manuscripts.

Dr. Rocha renewed a University of Pittsburgh IRB Study: Characterization of Infarct Growth Rate in

Acute Ischemic Stroke due to Large Vessel Occlusion. This study will lead to the publication of

important clinical retrospective studies as a continuation of work on the characterization of different sub-

types of ischemic stroke that will pave the way for translational research in future potential

neuroprotective therapies in stroke.

Dr. Rocha lectured in the multiple academic and community health care settings:

• Secondary Stroke Prevention. Neurology Residency Boot Camp. July 2017, University of

Pittsburgh Medical Center.

• Malignancy and Ischemic Stroke. UPMC Northwest Stroke Symposium. May 2017,

Franklin, PA.

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• Pathophysiology of Acute Cerebral Large Vessel Occlusion: Emerging Trends. Grand

Rounds Lecture, Department of Neurology, University of Pittsburgh Medical Center,

September 2016, Pittsburgh, PA.

• Drugs of Abuse and Stroke. UPMC Telestroke International Lecture, July 2016, Pittsburgh,

PA and Xuanwu Hospital, Beijing, China.

Matthew Starr, MD

Assistant Professor of Neurology

Dr. Starr created and maintains a database of basilar artery occlusion patients treated with

intraarterial therapy. Information from his database was used in collaboration with

physicians at Emory University on a paper published this year. Dr. Starr is working with

Dr. Samir Saba in the department of Cardiology on some projects dealing with

cardioembolic stroke, paroxysmal atrial fibrillation and left atrial appendage morphology.

Dr. Starr created a database to review efficacy of loop recorders in detecting occult

paroxysmal atrial fibrillation in our stroke patients. He is collaborating with Dr. Kormos in CT surgery

department on a project about LVAD and stroke. Dr. Starr was also the PI of the PRISMS trial looking at IV

TPA for minor strokes and we were the 5th leading enrollers in the study. He is the medical management

physician for the CREST 2 study and the blinded site PI for Actissima stem cell trial. He will be the PI in an

upcoming StrokeNet study managing Embolic Stroke of Unknown Source. Dr. Starr is a sub-I on multiple

stroke clinical trials.

Lawrence R. Wechsler, MD

Chair, Department of Neurology

Henry B. Higman Professor of Neurology / Neurosurgery

Vice President of Telemedicine, PSD

Lawrence Wechsler, MD, Professor of Neurology at the University of Pittsburgh School of

Medicine is Henry B. Higman Professor and Chair of the Department of Neurology. He also

serves as Vice President for Telemedicine in the Physician Services Division.

Dr. Wechsler’s interests include acute stroke therapy, imaging and telemedicine. He is a leader in the field of

vascular neurology and has participated on steering committees, advisory boards, or as a DSMB member for

numerous national and international clinical trials that have impacted practice and improved outcomes for stroke

survivors. Dr. Wechsler along with Dr. Kondziolka of the Department of Neurosurgery spearheaded the first clinical

trials of cellular therapy for treatment of stroke. Dr. Wechsler holds memberships in several organizations, including

the American Neurological Association, American Stroke Association, American Society of Neuroimaging and the

American Academy of Neurology. He is past Chair of the Stroke Systems Work Group at the American Academy

of Neurology and past President of the American Society of Neuroimaging. Dr. Wechsler has authored or co-

authored numerous articles related to stroke and stroke therapy.

Dr. Wechsler developed and implemented the telemedicine program for acute stroke assessment at UPMC. He was

an early proponent of telestroke program development, and currently oversees a network of 21 hospitals in the

western Pennsylvania area. Since the inception of the Telestroke service at UPMC, over 2,013 stroke patients have

been evaluated with outcomes the same as expected for patients treated face-to-face. In addition to Telestroke,

UPMC has expanded telemedicine to 35 specialty services lines across multiple locations and has active Teleconsult

centers across 3 locations in Western Pennsylvania where patients can be scheduled to have a virtual visit with a

specialist from Pittsburgh.

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St. Margaret/McKeesport

Stuart Silverman, MS, MD, FAAN

Clinical Associate Professor of Neurology

Stuart Silverman, MS, MD, FAAN, is board-certified in neurology and a Fellow of the American

Academy of Neurology. He has special interests and more than 25 years of experience in

multiple sclerosis, spinal diseases, and neuroimaging. He sees inpatients and outpatients for all

adult clinical neurology.

Dr. Silverman received his medical degree from Georgetown University School of Medicine in

Washington, D.C. He then completed his neurology residency at Georgetown University

Hospital.

Through the year I will continue to teach residents at both UPMC St. Margaret Hospital and UPMC McKeesport

Hospital to insure our consult service. I will also continue our MS Clinic and increase our neuroimaging practice.

Edward Mistler, MD

Clinical Assistant Professor of Neurology

Dr. Edward Mistler joined the Department of Neurology on January 1, 2014. Prior to joining,

he was in private practice for 10 years in Pittsburgh. He is primarily a clinical neurologist who

sees patients at 3 offices throughout Allegheny County; West Mifflin, Mckeesport and

Aspinwall.

Dr. Mistler has a special interest in NCS/EMG and botulinum toxin administration which he

performs at all offices. He serves on the Medical Executive Council for Mckeesport Hospital.

He is also responsible for all neurology consults at UPMC-Mckeesport Hospital and is the Stroke Medical Director

for UPMC Mckeesport. Duties as Stroke Director include a monthly meeting with the interdisciplinary team, and

weekly meeting with the clinical coordinator. UPMC Mckeesport Hospital is accredited by JACHO as a Primary

Stroke Center. Dr. Mistler also gave a presentation at UPMC Mckeesport Hospital Nursing Education lecture series

on June 13, 2017.

Dr. Mistler is responsible for neurological education for the medicine and family practice residents at Mckeesport

Hospital, and serves as the Neurologic Education director. This involves a 5-lecture series for the residents and 1

grand rounds per year of didactic lectures. He gave one grand rounds lecture on Stroke at Mckeesport Hospital

August 16, 2016. There are also small group sessions at least once per month and at least one resident from each

specialty is on the Neurology team each month and is directly supervised by Dr. Mistler. Dr. Mistler also supervises

one St. Margaret’s Family Practice Resident every Wednesday in the outpatient setting.

In addition to his outpatient duties and UPMC Mckeesport Hospital coverage, Dr. Mistler provides inpatient care to

patients at UPMC St. Margarets Hospital at least once per week. He covers both hospitals one week per month on

call.

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Northshore – Hamot Erie

James DeMatteis, MD

Division Chief of Neurology - Hamot

Medical Director Stroke Center – Hamot

Dr. DeMatteis specializes in stroke and neurovascular disease, Parkinson's disease, and

neurological rehabilitation. He is presently a staff neurologist at UPMC Hamot (formerly

known as Hamot Medical Center). He is the medical director for neuro rehabilitation at

HealthSouth Rehabilitation Hospital, Erie Pennsylvania. He is very actively involved in

education and patient care. He has won several awards; the one most cherished is the best

teacher award. He is also very actively involved in education. He is the annual course director

for Hamot Neurosciences. He has several board certifications in Neurology, Internal Medicine, Neurological

Rehabilitation, EMG, and Neurovasculaar Disease.

Dr. DeMatteis has been on the medical staff at UPMC Hamot since July 1984. In the past, he has been involved in

several phase 3 drug studies. To name a few, these have been Avail, Capture 2, Optima, Atlantis stroke study, and

ProFESS study. Presently he is involved in MARISS and NAVIGATE ESUS.

Jeffrey J. Esper, DO, MS (Med Ed)

Professor of Internal Medicine/Neurology, LECOM

UPMC Hamot Neurology Residency Program Director

UPMC Hamot Osteopathic Director of Medical Education

Dr. Esper is the neurology residency director at UPMC Hamot where he supervises 9 neurology

residents. He also serves as an instructor for the residents of emergency medicine at UPMC

Hamot and for the psychiatry, internal medicine and ophthalmology residents from Millcreek

Community Hospital. He is also the director of the EMG laboratory at UPMC Hamot. He has

successfully completed a Master’s degree in Health Services Administration in

May of 2017. He also serves as the director of the Muscular Dystrophy Clinic in Erie, Pa. Dr. Esper is clinical

course director for the neurosensory system at LECOM. This system runs from March until May each year where

Dr. Esper gives 25 lecture hours each year to the medical students. This duty also requires writing new test questions

for each lecture. Dr. Esper also develops case scenarios and differential diagnosis exercises for the students. Dr.

Esper teaches medical students in the classroom setting and in the clinical setting, both office and hospital settings.

Dr. Esper continues to serve as LECOM curriculum committee chairman. Dr. Esper also is an active participant and

examiner in the ACONP oral board certifying examinations each spring. He has participated in research projects

and case study posters and publications with the neurology residents. He is coauthoring, with a couple of the

neurology residents, a neurology related chapter in a neurosurgery textbook.

Erica Grazioli, DO, M.S. Med Ed

Neurologist

Director, UPMC Hamot MS Fellowship Program

Director, UPMC Hamot MS Center of Excellence

Medical Director UPMC Hamot Infusion Center

Dr. Grazioli is involved clinically in the care of patients with multiple sclerosis and sleep

disorders and is the director of the UPMC Hamot Multiple Sclerosis Center. The UPMC

Hamot Multiple Sclerosis Center is recognized as a Comprehensive Care Center by the

National Multiple Sclerosis Society and, as part of this relationship, a weekly

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multidisciplinary shared clinic is conducted at UPMC Northshore Neurology with representation from the local

National Multiple Sclerosis Society. Dr. Grazioli also completed the book chapter entitled Temporal and Clinical

Course of Multiple Sclerosis in Primer on Multiple Sclerosis, Second Edition, Oxford University Press, 2016.

Dr. Grazioli is active in medical education. Dr. Grazioli continues to regularly supervise neurology residents during

a one month multiple sclerosis rotation during the fourth postgraduate year as well and on EMG rotation. She is

active in resident didactics, lecturing monthly on sleep medicine and multiple sclerosis topics. She is also a lecturer

on multiple sclerosis for the Lake Erie College of Osteopathic Medicine. Additionally, Dr. Grazioli provides regular

“lunch and learn” seminars for the neurology advanced practice providers.

Daniel Kinem, DO

Chief of the Division of Neurology, UPMC Hamot

Neurohospitalist, UPMC Hamot

Medical Director, UPMC Hamot Neurophysiology Department

Dr. Kinem serves as the Chief of the Division of Neurology for UPMC Hamot. He also serves

as the lead neurohospitalist, Medical Director of the Neurophysiology Department and of the

UPMC Hamot Neurology floor. His duties include representing the neurology division in

hospital affairs, credentialing of physicians and other health care providers, peer review and

quality assurance for the neurology division, and the development and improvement of the acute stroke program.

As lead neurohospitalist, Dr. Kinem is charged with scheduling and coordinating hospital coverage.

Very active in teaching, Dr. Kinem directly mentors medical students, ED, IM, and psychology residents. In

addition, he has significant training and educational responsibilities for the UPMC Hamot Neurology Residency

Program. Dr. Kinem is also active in stroke rehabilitation as an admitting and consulting physician at Health South

Rehabilitation Hospital.

Lazarus Mayoglou, DO

Medical Director of Epilepsy Services in Neurology

Dr. Mayoglou has been working to set up a continuous ICU-EEG monitoring program, as well as

an epilepsy monitoring unit. Lecturing Neurology residents

Dimitrios Nacopoulos

Clinical Assistant Professor

Twice monthly Movement Disorders lectures for UPMC-Hamot Neurology residents and

rotating medical students has been part of the curriculum and will continue to grow, with plans

to incorporate quarterly video series for teaching purposes to trainees and faculty. Recently

appointed as assistant program director for the UPMC-Hamot Neurology residency program with

plans to expand teaching opportunities for faculty as well as incorporate new teaching strategies

for the residency program, such as clinical examination teaching. Working with program director

in identifying gaps in transition to ACGME accredited program. Providing mentorship to rotating medical students

through outpatient clinical experience. Continuing to grow the presence of UPMC’s neurology division through

public relations and events in the Parkinson’s community of Northwest Pennsylvania and the greater Tri-State

region. Collaboration with Dr. R. Mark Richardson, MD, PhD – neurosurgery UPMC-Presbyterian, in

multidisciplinary DBS clinic with plans on collecting data for future research.

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Jingzi Shang, MD

Neurologist

Director UPMC Sleep Disorder Center

Dr. Shang’s practice is primarily focused on caring for patients with sleep disorders and

headache. In addition she cares for patients general neurological problems as well. She does

Botox injection for chronic migraine patient. Dr. Shang also read polysomnogram and

electroencephalogram at UPMC Hamot – Erie.

Michelle Stevens, DO

Neurologist

Co-Director, MDA Clinic of Northwest PA Northshore Practices

Dr. Stevens is co-director of the Muscular Dystrophy Association Clinic of NWPA and

specializes in Neuromuscular disorders. She primarily sees patients with myasthenia gravis,

muscle diseases, and peripheral nerve disorders. She also has an interest in headache and

general neurology. She performs EMG studies in the UPMC Hamot EMG laboratory. Dr.

Stevens is active in Neurology resident and LECOM medical student education, mentoring

students on a nearly daily basis in the clinic and EMG lab.

Heritage Valley – UPMC

Erin Canale, MD

Clinical Assistant Professor of Neurology

During the academic year 2016 – 2017, Dr. Canale joined the providers at Heritage Valley-

UPMC Multispecialty Group Inc. in Monaca, Pennsylvania. This busy practice in Beaver County

was acquired by UPMC in 2015 and is staffed by 2 physicians and 2 physician assistants at a

stand-alone outpatient facility. Providers see all aspects of outpatient general neurology. Dr.

Canale also sees patients one day per week in Calcutta, OH in a neurologically underserved area.

In addition to general neurology outpatient responsibilities, Dr. Canale participates in reading EEGs for the

Continuous (ICU/CC) EEG Service based out of UPMC Presbyterian Shadyside, as well as reading outpatient EEGs

for Heritage Valley Beaver.

During the coming academic year, Dr. Canale will continue active clinical duties including teaching residents and

fellows in EEG.

Arthur R. Sonberg, MD

Clinical Assistant Professor of Neurology

During the academic year 2016-17, Dr. Sonberg continued to provide outpatient care at the

Heritage Valley UPMC Multispecialty Group facility in Monaca, PA. The facility serves the

Beaver County and surrounding areas as well as drawing patients from Ohio, West Virginia and

more distant areas of Pennsylvania. He has continued providing EEG and EMG services at

Heritage Valley Beaver. Dr. Sonberg also supervises the Monaca office, overseeing two

physician assistants and collaborating with the other office neurologists (as well as covering her

portion of the practice during maternity leave).

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Dr. Sonberg’s plans for the comoing 2017-18 timeframe include continuing practice in the Monaca/Beaver County

area and to continue working on a book which he would like to have published within the next few years. He

anticipates some additional pressure from the local practitioners for seeing more patients due to the impending

retirement of one of the other area neurologists who has been in practice in that area for many years.

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Study Sections and Advisory Committee Memberships

Anto Bagic, MD, PhD

Advisory Committee

Coordinator, American Epilepsy Society (AES) MEG SIG

Coordinator, American Clinical Neurophysiology Society (ACNS) NEG SIG

Member, Annual Meeting Program Committee, ACNS

Executive Committee Member, International Society for the Advancement of Clinical MEG

Board Member, National Association of Epilepsy Centers (NAEC)

Palatucci Advocacy Leadership Forum, American Academy of Neurology

AES Epilepsy Fellowship Program Director’s Committee

The German Federal Ministry of Education and Research and the ERA-NET NEURON (the NEURON Joint

Call Secretariat) the funding initiative “European Research Projects on Neurodevelopmental Disorders

Maria Baldwin, MD

Advisory Committee

Epilepsy Task Force (UPMC) – committee member assisting in development of status guidelines for the

hospital

Sarah B. Berman, MD, PhD

Study Section/Grant review

Parkinson Disease Foundation 2014-Present

United Mitochondrial Disease Foundation

Advisory Committees

Medical Advisory Board, Parkinson Foundation of Western Pennsylvania

Member, Outreach Program Committee, Parkinson Foundation of Western PA

Member, Advisory/Admissions/Steering Committees, Physician Scientist Training Program, UPSOM

Medicine

Member, Steering Committee, Neuroscience Area of Concentration, UPSOM

Member, Admissions/Recruiting Committee, Medical Scientist Trainign program/Center for Neuroscience at

UPSOM

Ad hoc interviewer, faculty recruitment, Department of Neurology UPMC

Edward Burton, MD, DPhil, FRCP

Advisory Committee

Cure PSP

Neil Busis, MD

Advisory Committees

UPMC

UPMC Patient Education Governance Committee

System-Wide Neurodiagnostic Committee

Data Governance Community

Data In/Data Out Workgroup

80

University of Pittsuburgh Physicians

Physician Services Division (PSD) Physician Clinical Quality Leadership Committee

Helping to pilot an educational module on physician communication to enhance patient satisfaction and

improve physician’s Press Ganey scores

UPMC Health Plan

UPMC Health Plan Specialty Care Work Group

UPMC Shadyside

Total Quality and Patient Safety Committee

Credentials Committee

UPMC Enterprises

Clinical Advisor to UPMC Enterprises

Department of Neurology

Chair, Value-Based Reimbursement Committee

Director, Neurodiagnostic Laboratory, UPMC Shadyside

Chief, Section of Neurology, Division of Medicine, UPMC Shadyside

Executive Committee, UPP Department of Neurology and Department of Neurology

Reviewer of Press Ganey data for outpatient services for UPP neurologists at UPMC Shadyside

Reviewer of HCAHPS and other Crimson data for UP neurologists performing inpatient services at UPMC

Presbyterian Shadyside

Planning Committee for 2nd Annual Neurology for the Medical Practioner Conference

UPP Department of Neurology Incentive Plan Committee

Leading Department of Neurology quality improvement project to decrease venous thromboembolism rates

on neurology inpatient services

Franca Cambi, MD, PhD

Advisory Committees

Scientific Advisory Board of the PMD Foundation

Guodong Cao, PhD

Study Sections

American Heart Association study section – IRG

Jun Chen, MD

Study Sections

VA RCS/Promotion Committee

Regular Member, NIH BINP Study Section

Ad hoc Reviewer: NIH Special Emphasis Review Panels; NIH Program Project Special Review

Panels; Department of Veterans Affairs Merit Review

Advisory Committees

Member, Board of Directors, International Society of Cerebral Blood Flow and Metabolism

Chair of the Membership Committee, International Society of Cerebral Blood Flow and Metabolism

University of Pittsburgh Department of Neurology, Recruitment Committee

Scientific Committee, Pittsburgh VA Health Care System

Program Committee, International Stroke Conference, American Heart Association

Steering Committee, American Heart Association Stroke Consul

81

Paula R. Clemens, MD

Study Sections

NIAMS Arthritis and Musculoskeletal and Skin Diseases Clinical Trials (AMSC) Review Committee

Advisory Committees

External

Member, Scientific Advisory Committee, NIH-sponsored National Registry for Myotonic Dystrophy and

Facioscapulohumeral Muscular Dystrophy Patients and Family

Chair, CINRG Publications Committee

Medical Director, Cooperative International Neuromuscular Research Group (CINRG)

Member, External Training Committee for the Ohio State University Muscle Group Training Program

Consultant, Reveragen

Member, Scientific Advisory Board for U01: Development of Novel Upper Extremity Outcome

Measures Using 3D-Vision Technology; PI: Jay Han, University of California Davis

Member, Pfizer DSMB

Member, North American Pompe Registry Board

Member, NIAMS DSMB University of Pittsburgh School of Medicine

Member, Molecular Genetics and Developmental Biology Graduate Training Program

Member, Cellular and Molecular Pathology Graduate Training Program

Member, MSTP and PSTP Student Advisory Committee, University of Pittsburgh

Member, PSTP Student Advisory Committee

Department of Neurology

Member, Executive Committee, Department of Neurology

Member, Neurology Faculty Promotions Committee, University of Pittsburgh

Co-Chair, Neurology Grand Rounds Committee

James DeMatteis, MD, FACP, FAAN

Advisory Committees

Education Committee for American Society of Neuro Rehabilitation

John Doyle, MD

Advisory Committees

Milestones Committee, University of Pittsburgh Department of Neurology

Jan Drappatz, MD

Study Section -

Neuro-Oncology Section, Alliance for Clinical Trials in Oncology, Committee member

Neuro-Oncology Task Force Development of Neuro-Oncology Pathways for high grade Glioma patients at

UPMC

ViaOncology, Neuro-Oncology Pathway Development, Brain Committee Chair

Advisory Committee

University of Pittsburgh

Committee Member, Neuro-Oncology Task Force, University of Pittsburgh

Internal Review Board, University of Pittsburgh

82

Data Safety Management Committee, University of Pittsburgh

Institutional Review Board

UPMC Neuro-Oncology Pathway Committee

Other

American Academy of Neurology

Alliance for Clinical Trials in Oncology – Neuro-Oncology Commmittee

American Association for Cancer Research

Charter member – BRAIN

Charter member – International Meningioma Society

International Primary CNS Lymphoma Collaborative Group

Society for Neuro-Oncology

Jeffrey Esper, DO, MS (Med Ed)

Advisory Committee

Committee on Medicine-Neurology, Bureau of Osteopathic Medicine and Surgery for POMA

Kathy Gardner, MD

Advisory Committees

Children’s Hospital of Pittsburgh

Co-Director, Neurofibromatosis Clinic

Adult Neurologist for the Tuberous Sclerosis Clinic

Pittsburgh

Advisor and board member, local Neurofibromatosis Clinics Association

REiNS (Response evaluation in neurofibromatosis and schwannomatosis) PRO Committee member

Gena Ghearing, MD

Advisory Committees

Clinical Neurophysiology Fellowship Committee

Neurology Residency Selection Committee

Residency Curriculum Committee

Clinical Competency Committee

Women in Neurology, University of Pittsburgh

Neurocritical Care Fellowship Selection Committee

American Clinical Neurophysiology Society Resident and Fellow Education

Graduate Medical Education Committee

Steven H. Graham, MD, PhD

Advisory Committees

University of Pittsburgh School of Medicine

Chair, Promotions Committee, Department of Neurology

Member, Executive Committee, Neurology Department

Department of Veterans Affairs

Member, VA VISN 4 Research Roundtable

Member, VA VISN 4 Academic Affairs Committee

Member, VA Pittsburgh Healthcare System, Medical Executive Board

Member, VA Pittsburgh Healthcare System, Executive Leadership Board

Treasurer, Veterans Research Foundation of Pittsburgh Board of Directors GRECC Director’s Association

83

Erica Grazioli, DO

Advisory Committees

Clinical Advisory Committee, National MS Society, Allegheny Chapter

J. Timothy Greenamyre, MD, PhD

Advisory Boards

National Advisory Boards

Member, Scientific Advisory Board, Parkinson’s Action Network

Member, Scientific Advisory Board, Cure Parkinson’s Foundation

Member, Scientific Advisory Board, Parkinson’s Disease Foundation

Executive Advisory Committee, Parkinson’s Disease Foundation

Member, Advisory Board, C. Mondino Institute of Neurology, Pavia, Italy

Member, Scientific Advisory Board, American Parkinson Disease Association

Member, Executive SAB, Michael J. Fox Foundation

Member, Neuroscience Therapeutic Area Scienfic Advisory Panel (TASAP), Pfizer

University of Pittsburgh

Co-Director, Huntington’s Disease Society of America Center of Excellence

School of Medicine MSTP Steering Committee

School of Medicine Committee for Tenured Faculty Promotions and Appointments (TFPA)

School of Medicine Health Sciences Research Advisory Committee

Department of Neurology, Executive Committee

Department of Neurology, Promotions Committee

Department of Neurology, Recruitment Committee

Max Hammer, MD

Advisory Committees

Member, Vascular Neurology Residency Program Interview Committee, Department of Neurology

Member, Residency Task Force Committee, Department of Neurology

Member, Professional Practice Evaluation Committee, Mercy Hospital

Member, Telestroke Executive Council

Member, Stroke Task Force Committee

Director, UPP Neurology Inpatient Services

Director of Stroke Services, UPMC Mercy Hospital and Shadyside Hospital

Director of Neurosonology Laboratory, Department of Neurology

Teresa Hastings, PhD

Advisory Committees

MSTP Steering Committee

MSTP/CNUP Admissions/Recruitment Committees

MSTP Program Evaluation Committee

University Council on Graduate Study

Promotions Committee - Department of Neurology

Tenure Stream Review Committee - Department of Neurology

Steering Committee, NIH/NIMH Institutional Predoctoral Training Grant

Executive Committee for PIND

84

Rock Heyman, MD

Advisory Committees

National Committees

National Multiple Sclerosis Society

Clinical Affiliations Committee

Medical Advisory Board, Executive Committee

National Council of Clinical Advisory Committee (CAC), Chairman

Member, Consortium of Multiple Sclerosis Centers

National Multiple Sclerosis Society, Keystone Chapter

Keystone Chapter Board of Trustees, executive committee

Chairman, Regional Clinical Advisory Committee, Chairman

University and School of Medicine Committees

UPMC Committees

Member, Epicare Record Implementation, Physician Leader

Director, Multiple Sclerosis Center

University of Pittsburgh School of Medicine

Member, Executive Committee, Neurology Department

Chief, Division of Neuroimmunology

Houman Homayoun, MD

Advisory Committee

Neurology Committee Member, MKSAP18, American College of Physicians

Xiaoming Hu, MD

Study Section

American Heart Association, Brain 3 study section

Milos Ikonomovic, MD

Study Section

NIH/CSR Brain Injury and Neruovascular Pathologies (BINP) Study Section, 2017/06

VA 2017/05 RRDI Brain Injury, TBI & Stroke, Special Emphasis Panel

VA RR&D Small Projects in Rehabilitation Research (SPiRE)

ZNS1 SRB-C(02), NINDS Special Emphasis Panel, November 2016

Ashutosh Jadhav, MD, PhD

Advisory Committees

Chairman, Vascular Neurology Fellowship Clinical Competency Committee

Member, University of Pittsburgh Neurology Residency Curriculum Committee

Member, Neurovascular & Neurocritical Care Conference Planning Committee

Member, UPMC Cerebrovascular Strategic Planning Committee

Society for Vascular and Interventional Neurology, BSLS committee

Society for Vascular and Interventional Neurology, Registry committee

85

Samay Jain, MD

Advisory Committees

National Organizations

Member, Parkinson Study Group, Other Non-motor Features Working Group

Member, Cardiovascular Health Study Neurology Working Group

University of Pittsburgh School of Medicine

Ad hoc Interviewer for Resident and Faculty Recruits

UPMC Institutional Review Board

Ruchira Menka Jha, MD

Advisory Committees

Neurocritial Care Team Coordination Committee

Neurocritical Care Fellowship Recruitment/Interview Committee

Neurology Vascular/Stroke Fellowship Recruitment and Interview Committee

Tudor Jovin, MD

Study Sections

Basilar Occlusion Chinese Endovascular Stroke (BAOCHE) Study – Co-PI

Member: Executive committee, Randomized Trial Comparing Transfer to the Closest Local Stroke Center vs.

Direct Transfer to Endovascualr Stroke Center of Acute Stroke Patients with Suspected Large Vessel

Occlusion in the Catalan Territory (RACECAT) Study

Chair: Neuroendovascular Surgery Advisory Council (NESAC), Committee on Advance Subspecialty Training

(CAST) Society of Neruological Surgeons

Advisory Committees

Founding Board Member, Society of Vascular and Interventional Neurology

Board of Directors Member, American Society of Neuroimaging

Executive Committee, IMS 3

SWIFT PRIME, Steering Committee

Carotid Revascularization Endarterectomy vs. Stent 2(CREST 2) trial, Interventional Credentialing Committee

ESCAPE, Steering Committee

Covidien Vascular, Global Advisory Board

Executive Committee, American Academy of Neurology, Interventional Neurology Section

American Heart Association, Board of Directors

NIH Stroke Trial Network, Interventional Advisory Committee

Chair: Neuroendovascular Surgery Advisory Council (NESAC), Committee on Advance Subspecialty Training

(CAST) Society of Neruological Surgeons

Robert Kaniecki, MD

Study Sections

American Academy of Neurology, Head and Facial Pain Section

American Headache Society, Refractory Headache Section

86

Advisory Committees

Chairman, Department of Neurology Scientific Review Committee

Member, Executive Committee, Department of Neurology

Member, Department of Neurology Residency Selection Committee

Member, Department of Neurology Quality Improvement Committee

Member, Department of Neurology Compensation Committee

Member, Neurology Value-Based Reimbursement Committee

Daniel Kinem, DO

Advisory Committees

University of Pittsburgh Medical Center Hamot

Member, Stroke Process Committee

Member, Ethics Committee

Laurie Knepper, MD

Advisory Committees

University of Pittsburgh and Medical School

Chair, Imaging Task Force UPSOM Curriculum Committee

Director of Neurology Clerkship Curriculum Committee

Women in Neurology Core Group, Department of Neurology

Curriculum Committee

Retention Committee

Promotions Committee

Child Neurology Clinical Competency Committee

Neurology Resident Milestone Committee

David Lacomis, MD

Advisory Committees

National Advisory Boards

Member, Scientific Advisory Board, Myasthenia Gravis Foundation of America

Member, North East Amyotrophic Lateral Sclerosis Consortium (NEALS)

Member, NEALS, cIRB MCTA Site Selection Metrics Committee

Member, ALS Research Group

University of Pittsburgh Physicians

Member, Epicare Oversight Committee, Neurology Department

Member, Executive Committee, Neurology Department

Member, Incentive Committee, Neurology Department

University of Pittsburgh School of Medicine

Member, Promotions Committee, Neurology Department

Erek Lam, MD

Advisory Committees

Stroke Certification Physician Liaison and Inpatient Stroke Quality, UPMC Passavant

87

Frank Lieberman, MD

Advisory Committees

Vice Chair, IRB (Oncology/Neuroscience)

University of Pittsburgh School of Medicine

Member, Bioethics Committee, UPMC Shadyside

Member, Protocol Initiation Committee, Scientific Review Committee (SRC) for Neuro-Radiology,

Member, Oncology Quality Improvement Council, University of Pittsburgh Cancer Institute

Oscar Lopez, MD

Study Sections

NIH, National Institute of Neurological Disorders and Stroke Special Emphasis Panel: ZNS1-SRB-G(68)

Advisory Committees

University of Pittsburgh School of Medicine

Department of Neurology Scientific Committee

Department of Psychiatry Scientific Committee

UPPA Credentialing Committee

Lewy Body Dementia Association, Scientific Advisory Committee

Working Group for the American Academy of Neurology Guidelines for the Diagnosis of

Mild Cognitive Impairment

Geriatric Research Education and Clinical Center (GRECC) Advisory Committee. VA Pittsburgh Healthcare

System, Pittsburgh, PA

National Heart, Lung, and Blood Institute (NHLBI): Consultant and Member of the Atherosclerosis Risk in

Communities Studies (ARIC) Monitor Board, Bethesda, MD

Cardiovascular Health Study Publications & Presentations Committee. National Heart, Lung and Blood

Institute (NHLBI).

Angela Lu, MD

Advisory Committee

Medical Student Neurology Clerkship Curriculum Committee

Neurology Resident Curriculum Committee

James McLaughlin, DO

Advisory Committees

ICU Committee

Physician Recuritment Committee

Quality Improvement Committee

UPMC Telemedicine Oversight Committee

UPMC Stroke QA Committee – System wide

Bradley Molyneaux, MD, PhD

Advisory Committees

Critical Care Medicine Fellowship selection interviews, University of Pittsburgh

Stroke Fellowship selection interviews, University of Pittsburgh Department of Neurology

Neurocritical Care Society – Annual meeting abstract reviewer and scientific program committee member

88

Ajitesh Ojha, MD

Advisory Committees

Neurology Rotation Curriculum Committee – UPMC

Neurology Curriculum Committee – UPC

Neurology Residency Selection Committee

Neurology Medical Student Education Committee

Jullie Pan, MD, PhD

Study Sections

NIH CSR Chartered member, Medical Imaging Study Section 2012-2016

Araya Puwanant, MD –

Study Sections

Advisory Committee for the NINDS NeuroNEXT clinical Research Site

Medical and Scientific Advisory Board for the Myasthenia Gravis Foundation of America

Marcelo Rocha, MD, PhD

Study Section

2016-17 participated in multi-disciplinary task force focused to reducing length of stay in patients admitted to

stroke servie at UPMC Presbyterian, Mercy and Shadyside hospitals.

Lori Shutter, MD, FCCM, FNCS

Study Section --

NIH SBIR Review Panel

Advisory Committee Membership

University of Pittsburgh Medical Center: Hospital

GME Committee

Special Institutional Education Programs Committee (SIEP)

University of Pittsburgh Medical Center: Department

CCM Fellowship Program Directors Committee

CCM Education Committee

Safer Symposium Annual Program Committee

Neurology Executive Committee, UPMC

Neurology Residency Curriculum Committee

Neurology Grand Rounds Planning Committee

UPSOM Non-Tenured Faculty Promotions and Appointments Committee

Stuart Silverman, MS, MD, FAAN

Advisory Committee Membership

Director, MS Service Society Tristate

Member MS Consortium Centers

89

Beth Snitz, PhD

Study Section

Reviewer, Western Psychiatric Institute and Clinic Research Committee

Ad hoc reviewer – Swiss National Science Foundation

NIA-NIH Special Emphasis Panel Reviewer

Pitt ADRC pilot proposal program

Dandan Sun, MD, PhD

Study Sections

NIH ZRG1 CMBG study section, regular member

Advisory Committees

Department of Veterans Affairs DVA Review Committee, Member (Neurobiology C)

AHA Peer Review Committee, Member, Brain 3

American Neurological Surgery Society Resident Research Fellowship Review Committee (Regular Member)

Valerie Suski, DO

Advisory Committees

Neurology Incentive Committee

Neurology Peer Review Committee

Alexandra Urban, MD

Study Sections

AAN Epilepsy Section, awareness of epilepsy and patient education

Practice Management Committee, American Epilepsy Society

Advisory Committees

LKB Neurology Clinic Improvement Committee

Women in Neurology

Clinical Neurophysiology Fellowship Clinical Competency Committee

Clninical Neurophysiology Fellowship Program Evaluation Committee

System Wide Neurodiagnostic Committee

Epilepsy Fellowship Clinical Competency Committee

Epilepsy Fellowship Program Evaluation Committee

Anne Van Cott, MD

Advisory Committees

National

Member of VA/DoD Quality Indicators for Epilepsy Treatment in the VA (QUIET-VA) Expert Panel

Chair, Women Veterans with Epilepsy VA National Epilepsy Centers of Excellence Workshop Group

University and Medical School

Neurology Medical Student Curriculum Committee

Neurology Promotions Committee

VA Professional Committees

VA Epilepsy Consortium VAPHS Medical and Surgical Clinic Expansion Committee

90

VA Research Committee

Member of VA Southeast Epilepsy Center of Excellence Steering

Member of VA Northeast Epilepsy Center of Excellence Advisory Committee

Local

Professional Advisory Board of the Epilepsy Foundation of Western/Central PA, Member

Janet Waters, MD

Advisory Committees

Neurology Resident Selection Committee

Incentive Committee – UPMC Dept of Neurology

Executive Committee – UPMC Dept of Neurology

Lawrence Wechsler, MD

Advisory Committees

National

Chair, Telemedicine Committee, American Stroke Association

Chair, American Society of Neuroimaging Foundation Board

Chair, DSMB Biogen ACTION I and II trials

Member, American Academy of Neurology, Vascular Neurology Task Force

Member, American Academy of Neurology, Representative to Brain Attack Coalition

Member, ATA Telestroke Guideline Committee

Member, Board of Directors, American Society of Neuroimaging

Member, Stroke System Work Group, American Academy of Neurology

Member, Telemedicine Work Group, American Academy of Neurology

Member, McKinney Award Committee, American Society of Neuroimaging

Member, ASN Program Committee

Steering Committee, ACT 1 Trial

University of Pittsburgh

Vice President for Telemedicine, UPMC

Co-director, Neuroscience service line

Member, Department of Neurology Executive Committee

Member, Department of Neurology Promotions Committee

University of Pittsburgh Physicians

Member, UPP Clinical Operations Committee

Kejie Yin, MD, PhD

Advisory Committee

Member, American Heart Association Brain-Stroke Basic Science 2 Peer Review Committee

Naoir Zaher, MD

Advisory Committee

Epilepsy Fellowship PEC (Program Evaluation) Commmittee

Feng Zhang, MD, PhD

Study Section

NSFC, China

91

Advisory Committee

University of Pittsburgh Institutional Animal Care & Use Committee

Michael J. Zigmond, PhD

Advisory Committees

National Advisory Boards:

Chair, Columbia University Udall Center Research Program on Parkinson's disease: Pathogenesis of

Dopamine Neuron Death (Robert Burke, PI)

Scientific Advisory Board, The Michael J. Fox Foundation for Parkinson’s

Scientific Advisory Board, Center for Biomedical Research Excellence, University of Puerto Rico

Chair, Program Advisory Committee, NINDS Specialized Neuroscience Research Program

University Central Del Caribe

Scientific Advisory Committee, Keystone Symposia

American Association for the Advancement of Science

AAAS Committee on Sections member

Neuroscience Section, Secretary

Society for Neuroscientists of Africa – Program Committee

Saša Živković, MD, PhD

Advisory Committees

Member, AAN Subspecialty Qualigy Advisors Group AAN

Member, Quality Improvement Committee, AANEM

Member, Vasculitis Working Group, Brighton Collaboration

Risk Management Review Committee, Department of Neurology, University of Pittsburgh

92

93

Research Grants and Contract Activity

LAST NAME FIRST

NAME AGENCY NAME TITLE OF GRANT

ANNUAL

DC

ANNUAL

IDC TOTAL

Federal Grants: Public Health Service Program Project Grants

K AWARDS

Xia Zongqui NATIONAL INSTITUTES

OF HEALTH

Leveraging genetics and environment to

predict presymptomatic multiple sclerosis $172,076.26 $13,766.08 $185,842.34

$185,842.34

PROGRAM PROJECTS

Clemens Paula Children’s Research

Institute P50 Project 3 $7,116.66 $3,665.09 $10,781.75

Clemens Paula Children’s Research

Institute P50 Admin Core A $1,204.86 $620.50 $1,825.35

Clemens Paula Children’s Research

Institute P50 Project 3 Patient Care Costs $561.49 -$384.59 $176.90

Greenamyre John NATIONAL INSTITUTES

OF HEALTH

Pittsburgh Older Americans Independence

Center $9,198.29 $4,967.03 $14,165.32

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Project 3 $165,693.21 $89,474.32 $255,167.53

Ikonomovic Milos St. Joseph’s Hospital Neurobiology in Mild Cognitive Impairment

in the Elderly $239,013.29 $127,592.39 $366,605.68

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH ADRC – Admin Core A $179,991.48 $96,972.61 $276,964.09

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Alzheimer’s Disease Research Center –

Clinical Core B $415,065.48 $224,135.37 $639,200.85

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH ADRC Core F (Pat Kethchel) $9,323.75 $5,034.83 $14,358.58

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Core A $62,042.94 $33,503.21 $95,546.15

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Project 1 $128,981.04 $37,910.99 $166,892.03

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Project 2 $31,614.20 $16,006.03 $47,620.23

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Project 4 $19,583.04 $10,574.83 $30,157.87

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH ADRC – Admin Project 2 $2,506.13 $1,353.32 $3,859.45

Sanders Laurie NATIONAL INSTITUTES

OF HEALTH ADRC Pilot 2 $8,892.66 $4,802.02 $13,694.68

Snitz Beth NATIONAL INSTITUTES

OF HEALTH ADRC – Core E $76,093.66 $41,090.64 $117,184.30

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Alzheimer’s Disease Research Center –

Project 1 $59,069.30 $19,384.47 $78,453.77

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Imaging Pathophysiology in Aging and

Neurodegeneration Core B $62,051.91 $33,431.09 $95,483.00

Snitz Beth NATIONAL INSTITUTES

OF HEALTH ADRC – Core A $24,812.86 $13,398.97 $38,211.83

$ 2,266,349.37

94

U AWARDS

Bagic Anto Emory University Connections of Brain Aging and Dementia

(CBAD) $3,095.00 $1,671.30 $4,766.30

Bagic Anto Washington University Maternal Outcomes and Neurodevelopment

Effects of Antiepileptic Drugs $16,829.57 $9,088.00 $25,917.57

Berman Sarah NATIONAL INSTITUTES

OF HEALTH DIAN Study $77,443.68 $27,105.35 $104,549.03

Clemens Paula NATIONAL INSTITUTES

OF HEALTH

VBP15, An Innovative Steroid-like

Intervention on DMD: Vision-DMD $38,743.73 $20,921.67 $59,665.40

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Neurodegeneration in Aging in Down

Syndrome (NiAD): A Longitudinal Study of

Cognition and Biomarkers of Alzheimer’s

Disease

$16,852.28 $9,100.22 $25,952.50

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Neurodegeneration in Gaining Down

Syndrome (NiAD) $2,764.33 $1,492.75 $4,257.08

Jadhav Ashutosh Massachusetts General

Hospital NN104/Rhapsody $127,679.37 $58,829.67 $186,509.04

Jankowitz Brian John Hopkins University

Minimally Invasive Surgery =+rt-PA for

Intracerebral hemorrhage evacuation –

MISTIE III

$21,838.87 $5,217.19 $27,056.06

Lopez Oscar HRSA Geriatric Workforce Enhancement Program $17,134.35 $1,370.76 $18,505.21

Lopez Oscar University of Southern

California

A Phase 2a Multi-Center Study of 18F-FDG

PET, safety and tolerability of AZD0530 in

Mild Alzheimer’s Disease

$31,856.30 $4,389.36 $36,245.66

Lopez Oscar University of Southern

California

Alzheimer’s Disease Neuroimaging Imitative

2 (ADNI2) $9,115.32 $318.10 $9,433.42

Lopez Oscar University of Washington NACC Minimum Data Set (MDS) Project $6,741.92 $3,640.60 $10,382.52

Lopez Oscar University of Southern

California

Alzheimer’s Disease Cooperative Study – A4

Study $14,452.85 $4,335.85 $18,788.70

Reddy Vivek NATIONAL INSTITUTES

OF HEALTH Point Project $4,428.67 $2,325.06 $6,753.73

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Connections of Brain Aging and Dementia

(CBAD) $104,394.66 $56,373.15 $160,767.81

Suski Valerie Massachusetts General

Hospital

Phase 3 trial of inosine for Parkinson’s

Disease CCC (SURE PD) $11,851.07 $3,555.33 $15,406.40

Suski Valerie NATIONAL INSTITUTES

OF HEALTH NeuroNEXT Ibudilast Study $6,985.25 $619.53 $7,604.68

Suski Valerie Massachusetts General

Hospital NeuroNEXT NN105 STAIR Study $2,233.48 $637.72 $2,871.20

Urban Alexandria University of Michigan Established Status Epilepticus Treatment

Trial $3,868.76 $2,089.13 $5,957.89

Wechsler Lawrence NATIONAL INSTITUTES

OF HEALTH

Network of Excellence in Neuroscience

Clinical Trials $185,883.23 $95,729.86 $281,613.09

Wechsler Lawrence NATIONAL INSTITUTES

OF HEALTH

Stroke Trials Network – Regional

Coordinating Stroke Center (STN-UP) $200,696.69 $98,214.49 $298,911.18

Wechsler Lawrence NATIONAL INSTITUTES

OF HEALTH

Neurological Emergencies Treatment Trial

(NETT) Network Pittsburgh Clinical Hub $8,431.35 $4,342.13 $12,773.48

Wechsler Lawrence University of Michigan SHINE Project Year 2 $1,169.41 $613.94 $1,783.35

Wechsler Lawrence May Clinic Jacksonville

CREST II Carotid Revascularization and

Medical Management for Asymptomatic

Carotid Stenosis Trial

$28,120.42 $12,165.89 $40,286.31

$ 1,366,757.61

95

R AWARDS

Berman Sarah NATIONAL INSTITUTES

OF HEALTH

Neuronal regulation of mitochondrial

dynamics in models of Parkinson’s Disease $217,339.71 $117,298.14 $334,637.85

Berman Sarah NATIONAL INSTITUTES

OF HEALTH

PINK1 Regulation of Neuronal and

Mitochondrial Homeostasis $10,151.59 $5,481.88 $15,633.47

Burton Edward NATIONAL INSTITUTES

OF HEALTH

Development of zebrafish taupoathy models

for translational research $2,908.26 $1,526.84 $4,435.10

Burton Edward NATIONAL INSTITUTES

OF HEALTH

Pathogenic mechanisms of gene-environment

interactions in Parkinson’s Disease $256,084.39 $138,285.64 $394,370.03

Burton Edward NATIONAL INSTITUTES

OF HEALTH

ROS driven mitochondrial-telomere

dysfunction during environmental stress $9,558.52 $4,918.66 $14,477.18

Cao Guodong NATIONAL INSTITUTES

OF HEALTH White Matter Protection in Cerebral Ischemia $238,323.15 $111,416.60 $349,739.75

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Neuroprotection in Models of Cerebral

Ischemia $81,765.64 $42,109.34 $123,874.98

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Mechanisms of Neurovascular Injury in

Cerebral Ischemia $197,627.14 $97,586.52 $295,213.66

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Na+K+Cl Contransporter in Cerebral

Ischemia $7,923.15 $4,278.51 $12,201.66

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Antidote for inhaled CO poisoning based on

mutationally engineered neuroglobin $7,923.15 $4,278.51 $12,201.66

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Role of CyPgs UCH-L1 in Ischemic Injury

and Recovery $38,031.51 $20,537.07 $58,568.58

Chen Jun NATIONAL INSTITUTES

OF HEALTH

White matter restoration and functional

recovery after experimental stroke $241,311.20 $129,408.12 $370,719.32

Chen Jun NATIONAL INSTITUTES

OF HEALTH

Molecular therapies to promote white matter

restoration after traumatic brain injury $299,270.90 $88,525.98 $387,796.88

Chen Jun NATIONAL INSTITUTES

OF HEALTH MicroRNAs and post-stroke angiogenesis $109,481.39 $47,109.07 $156,590.46

Chen Jun NATIONAL INSTITUTES

OF HEALTH Inducible DNA repair in cerebral ischemia $136,384.46 $67,842.06 $204,226.52

Clemens Paula Children’s Research

Institute

Biomarker Discover and Validation in a

Duchenne Dystrophy Natural History Study:

Agreement 2

$463.91 $243.56 $707.47

Graham Steven NATIONAL INSTITUTES

OF HEALTH

Role of CyPgs UCH-L1 in Ischemic Injury

and Recovery $165,985.07 $89,319.43 $255,304.50

Greenamyre John NATIONAL INSTITUTES

OF HEALTH

MtDNA Damage as a Biomarker for

Environmental Mitochondrial Toxicity $41,068.14 $21,150.09 $62,218.23

Greenamyre John NATIONAL INSTITUTES

OF HEALTH

MtDNA Damage as a Biomarker for

Environmental Mitochondrial Toxicity –

Supplement

$180,212.71 $58,326.62 $238,539.33

Greenamyre John NATIONAL INSTITUTES

OF HEALTH

Alpha-synuclein inhibition of mitochondrial

protein import $309,144.56 $165,836.37 $474,980.93

Greenamyre John NATIONAL INSTITUTES

OF HEALTH

A slowly progressive, endogenous

synucleinopathy model of Parkinson’s disease $19,289.34 $10,176.34 $29,465.68

Greenamyre John University of Texas Health

Science Center

Effects of Insulin-like signaling, aging, and

ubiquinone on C. Elegnas muscle $5,893.04 $3,093.86 $8,986.90

Hu Xiaoming NATIONAL INSTITUTES

OF HEALTH

Immunomodulation of white matter integrity

after stroke $213,182.90 $111,263.93 $324,446.83

Hu Xiaoming NATIONAL INSTITUTES

OF HEALTH

Regulatory T Cell as a restorative therapy for

ischemic stroke $168,147.66 $84,760.73 $252,908.39

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Alpha-synuclein and synaptic vesicle

dysfunction after traumatic brain injury $8,063.98 $4,354.55 $12,418.53

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Development of a PET Tracer Selective for

cerebral amyloid angiopathy $94,504.07 $49,920.38 $144,424.45

Ikonomovic Milos NATIONAL INSTITUTES

OF HEALTH

Natural History of Amyloid Deposition in

Adults with Down Syndrome $9,847.97 $5,317.92 $15,165.89

96

Jovin Tudor Stanford University Imaging of Collaterals in Acute Stroke

(iCAS) $14,231.20 $7,684.85 $21,916.05

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Resilience to Mobility Impairment: Neural

Correlates and Protective Factors $557.37 $287.04 $844.41

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Ultra-high field neuroimaging in elderly after

a two-year exercise intervention $11,016.58 $5,948.97 $16,965.55

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Omega-3, isoflavones & amyloid deposition

in cognitively normal elderly Japanese $4,875.05 $2,632.56 $7,507.61

Lopez Oscar NATIONAL INSTITUTES

OF HEALTH

Role of midlife cardiovascular disease on

Alzheimer’s Pathology and cerebrovascular

reactivity in the young-old

$44,577.32 $24,071.77 $68,649.09

Lopez Oscar University of California San

Diego Characterizing Cognitive Decline in Late Life

Depression – the ADNI-D Project

$14,547.44 $4,364.26 $18,911.70

Lopez Oscar Harvard University Novel lipoprotein particles, brain

abnormalities and risk of dementia and stroke

$13,096.17 $7,071.94 $20,168.11

Lopez Oscar University of Southern

California

Characterizing Cognitive Decline in Late Life

Depression – the ADNI-D Project $6,830.57 $383.28 $7,213.85

Pan Jullie NATIONAL INSTITUTES

OF HEALTH

Multiplexed Multiband MR at 7T: Studies of

Mild Traumatic Brain Injury $2,456.09 $1,289.45 $3,745.54

Pan Jullie NATIONAL INSTITUTES

OF HEALTH

Localization of Surgical Epilepsy: MR

Spectroscopic Imaging $528,613.54 $78,220.18 $606,833.72

Popescu Alexandra NATIONAL INSTITUTES

OF HEALTH

Inside the social perception network:

dynamics, connectivity and stimulation $3,094.95 $1,671.27 $4,766.22

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Amyloid pathology and cognition in normal

elderly $19,210.22 $10,373.54 $29,583.76

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Mild cognitive impairment: A prospective

community study $14,189.20 $7,662.13 $21,851.33

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Role of midlife cardiovascular disease on

Alzheimer’s Pathology and cerebrovascular

reactivity in the young-old

$3,431.54 $1,853.07 $5,284.61

Snitz Beth NATIONAL INSTITUTES

OF HEALTH

Alzheimer neuroimaging-biomarkers in pre-

clinical cognitive decline from a population-

based study

$108,752.13 $43,912.40 $152,664.53

Stetler Ruth NATIONAL INSTITUTES

OF HEALTH DNA repair promotes stroke recovery $11,516.27 $5,249.49 $16,765.76

Sun Dandan NATIONAL INSTITUTES

OF HEALTH

Na-K-CL contransporter (NKCC1) in

Gilioblastoma Multiforme $161,502.65 $54,961.03 $216,463.68

Sun Dandan NATIONAL INSTITUTES

OF HEALTH

Na-K-CL contransporter (NKCC1) in

Gilioblastoma Multiforme – Supplement $8,659.03 $0.00 $8,659.03

Sun Dandan NATIONAL INSTITUTES

OF HEALTH

Liberation of Intracellular zinc and neuronal

cell death $10,388.49 $5,609.81 $15,998.30

Sun Dandan NATIONAL INSTITUTES

OF HEALTH Na-K-Cl cotransporter in cerebral ischemia $268,976.65 $131,835.38 $400,812.03

Sun Dandan NATIONAL INSTITUTES

OF HEALTH Targeting ER stress in TBI $146,807.40 $75,877.18 $222,684.58

Sun Dandan NATIONAL INSTITUTES

OF HEALTH

Novel long non-coding RNAs in neuronal

survival in focal cerebral ischemia $8,570.50 $4,628.08 $13,198.58

Sun Dandan NATIONAL INSTITUTES

OF HEALTH

The role on Na/H exchanger in cerebral

ischemia $124,107.27 $66,897.20 $191,004.47

Sun Dandan NATIONAL INSTITUTES

OF HEALTH White matter protection in cerebral ischemia $8,310.77 $4,487.83 $12,798.60

Suski Valerie NATIONAL INSTITUTES

OF HEALTH

Neural substrates of deterministic decision

making $645.31 $348.47 $993.78

Wechsler Lawrence Rutgers University CREST $6,317.71 $1,516.22 $7,833.93

Xia Zongqi NATIONAL INSTITUTES

OF HEALTH

Integrating electronic health records and

genomics to predict Multiple Sclerosis drug

response

$73,139.88 $39,028.05 $112,167.93

97

Yin Kejie NATIONAL INSTITUTES

OF HEALTH

Long non-coding RNAs and cerebrovascular

endothelial cell pathology in ischemic stroke $90,833.26 $49,050.01 $139,883.27

Yin Kejie NATIONAL INSTITUTES

OF HEALTH MicroRNAs and post-stroke angiogenesis $168,333.85 $81,596.65 $249,930.50

Yin Kejie NATIONAL INSTITUTES

OF HEALTH Kruppel-like factor 11 and ischemic stroke $201,847.36 $108,969.15 $310,816.51

Zhang Feng NATIONAL INSTITUTES

OF HEALTH

A novel mechanism of neurovascular

protection in ischemic tolerance $252,269.16 $136,225.38 $388,494.54

Zigmond Michael NATIONAL INSTITUTES

OF HEALTH

Mechanisms of exercise-induced protection

and rescue in models of dopamine loss $5,974.62 $3,076.94 $9,051.56

Zigmond Michael NATIONAL INSTITUTES

OF HEALTH

Building international research ethics capacity

in China $257,042.16 $20,563.44 $277,605.60

Zigmond Michael NATIONAL INSTITUTES

OF HEALTH

Selective Glucocorticoid action in the

developing brain $13,889.93 $7,500.56 $21,390.49

Zigmond Michael Case Western Reserve

University

Role of GDNF and ER stress in effects of

acupuncture in models of Parkinsonism $89,709.45 $48,336.42 $138,045.87

Zigmond Michael Case Western Reserve

University

Reposition Gilptins for Parkinson’s disease

treatment $14,482.66 $0.00 $14,482.66

$ 8,310,241.98

Commonwealth Grants

Greenamyre John

Commonwealth of

Pennsylvania Department of

Education

Pittsburgh Institute for Neurodegenerative

Diseases $637.89 0 $637.89

$ 637.89

Other Federal Grants

Burton Edward National Science

Foundation

Towards Assessing and Mitigating the

Toxicity of Metal Nanoparticles $1,501.19 $792.86 $2,303.05

Clemens Paula Children’s Hospital of

Pittsburgh

Clinical trial of Coenzyme Q10 and

Prednisone in Duchenne M.D. $82,851.57 $20,712.95 $103,564.52

Clemens Paula Children’s Research

Institute

Establishing Minimal Clinically Important

Differences for Current Clinical Trial

Endpoints and Composite Outcome Measure

in Duchenne Muscular Dystrophy Agreement

7

$2,856.53 $1,499.69 $4,356.22

Clemens Paula ReveraGen BioPharma, Inc. Phase IIa Study of VBP15 for the Treatment

of Duchenne Muscular Dystrophy $42,578.82 $22,992.58 $65,571.40

Ikonomovic Milos U.S. Army In Vivo Neuroimaging Biomarker Panel for

Chronic Traumatic Encephalopathy $786.81 $424.86 $1,211.67

Lopez Oscar Department of Defense Chemogenics Systems Pharmacology

approach for TBI and AD Research $14,544.11 $7,853.80 $22,397.91

Lopez Oscar Ohio State University Women Health Initiative – Regional Center $2,013.11 $1,087.09 $3,100.20

Sun Dandan U.S. Army Chemogenics Systems Pharmacology

approach for TBI and AD Research $9,349.70 $5,048.87 $14,398.57

$216,903.54

98

Society and Foundation Funding

Andolina Laurie Bumpus Foundation

Mitochondrial DNA damage: screening tool

and novel therapeutic target for Parkinson’s

Disease

$13,776.60 $0.00 $13,776.60

Andolina Laurie Michael J. Fox Foundation Lrrk2 kinase activity and mitochondrial DNA

dame in Parkinson’s Disease $16,995.71 $1,699.57 $18,695.28

Burton Edward UPMC

Neuronal mitochondrial quality control in

vivo: live imaging of mitophagy in dopamine

neurons during aging and age

$19,117.48 $0.00 $19,117.48

Clemens Paula Muscular Dystrophy

Association

CINRG Becker Natural History Study –

Travel Funding $1,145.30 $114.54 $1,259.84

Clemens Paula Foundation to Eradicate

Duchenne, Inc.

Use of Microsoft Bands as an outcome

measure in boys with DMD – Parallel study

to Clinical Study Protocol VBP15

$10,661.17 $2,665.39 $13,326.56

DiMaio Roberto RiMED Foundation Cannabinoids therapeutic potential in the

prevention of chronic epilepsy $121,314.91 $36,248.83 $157,563.74

Greenamyre John American Parkinson’s

Disease Association

PET, Posturographic and Clinical Marker of

Early PD $39,810.20 $0.00 $39,810.20

Greenamyre John DSF Charitable Foundation Research on Mitochondria in

Neurodegenerative Disease $63,694.84 $0.00 $63,694.84

Hu Xiaoming AHA DHA post-treatment alleviates white matter

injury after cerebral ischemia $48,777.08 $4,877.74 $53,654.82

Lacomis David Massachusetts General

Hospital

A Multicenter Study for the Discovery and

Validation of Serial ALS Biomarkers $30,509.54 $4,576.43 $35,085.97

Lopez Oscar University of Southern

California

Alzheimer’s Disease Neuroimaging Initiative

3 (ADNI 3) $9,730.46 $2,919.14 $12,649.60

Lopez Oscar University of Southern

California

Longitudinal Evaluation of Amyloid Risk and

Neurodegeneration – the LEARN Study $22,773.53 $2,277.37 $25,050.90

Rocha Emily American Parkinson’s

Disease Association

Defining the role of glucocerebrosidase and

TFEB in Parkinson’s Disease $21,168.50 $0.00 $21,168.50

Rocha Emily PDF

Loss of glucocerebrodidase increase

dopaminergic neuronal vulnerability by

impairing autophagy flux

$54,962.44 $0.00 $54,962.44

Shi Yejie AHA Heat Shock Proteins and Neurovascular

Protection in Cerebral Ischemia $25,258.09 $0.00 $25,258.09

Song Shanshan AHA

Targeted knockout of microglial Na+/H+

exchanger-1 in mice improves neurological

function recovery after stroke

$22,777.82 $0.00 $22,777.82

Starr Matthew Duke University

Patient-Centered Research into Outcomes

Stroke Patients Prefer and Effectiveness

Research

$1,250.00 $500.00 $1,750.00

Suski Valerie CHDI Foundation, Inc

Enroll-HD: A Prospective Registry Study in

Global Huntington’s Disease Cohort A CHDI

Foundation Project

$61,641.89 $9,246.26 $70,888.15

Van Laar Amber American Brain Foundation

Parkin overexpression and the role of

neuroprotection clinician-scientist

development award

$77,140.98 $0.00 $77,140.98

Zivkovic Sasa GBS/CIDP Foundation

International

International Guillain-Barre Syndrome

Outcome Study (IGOS) $379.50 $199.26 $578.76

$ 728,210.57

Veterans Administration Medical Center Grants

Burton Edward US Department of Veterans

Affairs IPA Jianming Chen $34,810.52 $0.00 $34,810.52

Cao Guodong US Department of Veterans

Affairs IPA F. Chen $21,076.97 $0.00 $21,076.97

99

Chen Jun US Department of Veterans

Affairs IPA Zhongfang Weng $18,830.97 $0.00 $18,830.97

Chen Jun US Department of Veterans

Affairs IPA Sulaiman Hassan $43,804.22 $0.00 $43,804.22

Chen Jun US Department of Veterans

Affairs IPA Feng Zhang $27,235.95 $0.00 $27,235.95

Chen Jun US Department of Veterans

Affairs IPA Qing Ye $35,592.45 $0.00 $35,592.45

Chen Jun US Department of Veterans

Affairs IPA Yejie Shi $13,431.64 $0.00 $13,431.64

Clemens Paula US Department of Veterans

Affairs IPA Daniel Reay (CPPF) $23,206.26 $0.00 $23,206.26

Clemens Paula US Department of Veterans

Affairs IPA Daniel Ready (GREC) $15,565.19 $0.00 $15,565.19

Graham Steven US Department of Veterans

Affairs VA Contract Marie Rose $10,494.80 $0.00 $10,494.80

Graham Steven US Department of Veterans

Affairs IPA Marie Rose $31,484.44 $0.00 $31,484.44

Ikonomovic Milos US Department of Veterans

Affairs IPA Zhiping Mi $63,922.73 $0.00 $63,922.73

Ikonomovic Milos US Department of Veterans

Affairs IPA William Paljug $35,645.11 $0.00 $35,645.11

Sun Dandan US Department of Veterans

Affairs IPA Victoria Pigott $35,812.04 $0.00 $35,812.04

Sun Dandan US Department of Veterans

Affairs IPA Karen Carney $26,726.84 $0.00 $26,726.84

Sun Dandan US Department of Veterans

Affairs IPA Shanshan Song $5,029.58 $0.00 $5,029.58

$ 442,669.71

Industry Research Funding

Bagic Anto Persyst Development Corp

Multi-reader marked adult seizure EEG

dataset: comparison of human expert

assessments to Persyst automated seizure and

spike detection results

$18,975.00 $11,195.25 $30,170.25

Berman Sarah Quintiles

A Phase II/III randomized, double-blind,

placebo-controlled, multicenter study of 3

potential disease modify (DIAN-TU)

$173,293.88 $43,323.64 $216,617.52

Clemens Paula Genzyme Global Acid-Alfa-Glucosidase Treatment

Sustainability Program (GATS) $53.25 $0.00 $53.25

Clemens Paula Genzyme

A Prospective Safety Sub-Registry to Assess

Anaphylaxis and Severe Allergic Reactions

and Severe Cutaneous and Systemic

Immune-Mediated Reactions with

Alglucosidase Alfa Treatment

$1,480.89 $370.24 $1,851.13

Clemens Paula Children’s Research

Institute NS Pharma Phase 2 Project set-up $7,899.33 $4,858.10 $12,757.43

100

Clemens Paula ReveraGen BioPharma Phase IIa Study of VBP15 for the Treatment

of Duchenne Muscular Dystrophy $3,712.00 $2,004.50 $5,716.50

Clemens Paula Children’s Research

Institute

A multi-center collaborative study on the

clinical features, expression profiling, and

quality of life of infantile onset

facioscapulohumeral muscular dystrophy

$647.61 $194.29 $841.90

Clemens Paula TRiNDS

A Phase II, Dose Finding Study to Assess the

Safety, Tolerability, Pharmacokinetics, and

Pharmacodynamics of NS-065/NCNP-01 in

Boys with Duchenne Muscular Dystrophy

$533.72 $328.23 $861.95

Clemens Paula Genzyme Lysosomal Disorders Registry $7,604.26 $1,901.08 $9,505.34

Greenamyre John Merck

Development of a rodent model of GBA1

mutant carriers in sporadic Parkinson’s

Disease

$34,188.55 $19,939.64 $54,128.19

Greenamyre John Sanofi-Aventis

Screening of LRRK2 therapeutics for

Parkinson's disease based on a mitochondrial

phenotype (LRRK2 screening)

$4,297.30 $2,642.84 $6,940.14

Greenamyre John Sanofi-Aventis

Screening of LRRK2 therapeutics for

Parkinson's disease based on a mitochondrial

phenotype (Assay validation)

$15,599.03 $9,593.12 $25,192.15

Greenamyre John Biogen Testing Parkinson's therapeutics in an novel

animal model $57,149.86 $35,147.17 $92,297.03

Ikonomovic Milos General Electric

Assessing the influence of cored and diffuse

Ab plaquest on CN-Flutemetamol

fluorescence signal in histological sections

from Alzheimer’s disease brains

$6,779.32 $3,999.82 $10,779.14

Jain Samay Voyager Therapeutics

An Open-label Safety and Efficacy Study of

Escalating Doses of AAV2-hAADC

Administered by MRI-Guided Convective

Infusion into the Putamen of Participants with

Parkinson’s Disease with Fluctuating

Responses to Levodopa

$42,160.06 $14,756.04 $56,916.10

Lopez Oscar University of California Anti-Amyloid Treatment in Asymptomatic

Alzheimer’s Disease (Study A4) $2,323.99 $581.00 $2,904.99

Lopez Oscar University of California

A Phase 2 multi-center, randomized, double

blind, placebo controlled, parallel group study

to evaluate the efficacy and safety of T-

817MA in patients with mild to moderate

Alzheimer's Disease (US202)

$69,056.14 $17,264.12 $86,320.26

Lopez Oscar University of Southern

California

Anti-Amyloid Treatment in Asymptomatic

Alzheimer's Disease $131,404.85 $61,650.67 $193,055.52

Wechsler Lawrence Sunovion Pharmaceuticals

A double-blind controlled Phase 2B Study of

the Safety and Efficacy of Modified Stem

Cells (SB623) in patients with Chronic Motor

Deficit from Ischemic Stroke (Sanbio 2 Un-

blinded)

$2,956.56 $886.97 $3,843.53

Wechsler Lawrence Sunovion Pharmaceuticals

A double-blind controlled Phase 2B Study of

the Safety and Efficacy of Modified Stem

Cells (SB623) in patients with Chronic Motor

Deficit from Ischemic Stroke (Sanbio 2 Un-

blinded)

$15,928.40 $4,778.54 $20,706.94

Wechsler Lawrence SanBio

A Phase 1/2A Study of the safety and efficacy

of modified stromal cells in patients with

stable ischemic stroke

$137,473.43 $48,115.68 $185,589.11

$ 1,017,048.37

$ 14,534,661.38

101

Faculty Research Collaborations

Arun Antony, MD

Murat Akcakaya, PhD University of Pittsburgh Department of Engineering

Brian Hanrahan, MD Chippenham Hospital, Richmond, VA, Department of Internal Medicine

Pulkit Grover, PhD Carnegie Mellon, Department of Engineering

Burak Erem, PhD Northwestern University, Boston, MA, Department of Electrical

Engineering

Rebecca Mackenzie, PhD University of Minnesota, Department of Chemistry

Anto Bagic, MD, PhD

James Becker, PhD University of Pittsburgh Department of

R. Mark Richardson, MD, PhD University of Pittsburgh Department of Neurosurgery

Jullie Pan, MD, PhD University of Pittsburgh Department of Neurology

Fernando Maestu, PhD Aalto University, Helsinki, Finland

Wei Wang, MD, PhD University of Pittsburgh Department of Bioengineering, Physical

Medicine and Rehabilitation

Gustavo Sudre, PhD NIMH, NIH, Bethesda, MD

Douglas Weber, PhD University of Pittsburgh Department of Bioengineering

Mark Scheuer, MD Persyst Development Corporation, Prescott, AZ

Xin Li, PhD Carnegie Mellon University Department of Electrical and Computer

Engineering

Michael Cole, PhD Rutgers University Center for Molecular & Behavioral Neuroscience

Richard Randall, PhD Carnegie Mellon University School of Music

Julie Fiez, PhD University of Pittsburgh Department of Neuroscience

Rita Hari, MD, PhD, Aalto University, Helsinki, Finland

Sarah Berman, MD, PhD

Edward Burton, MD, Phil University of Pittsburgh Department of Neurology

J. Timothy Greenamyre, MD, PhD University of Pittsburgh Department of Neurology

Valerie Suski, DO University of Pittsburgh Department of Neurology

Laurie Sanders, PhD University of Pittsburgh Department of Neurology

Kenneth Hallows, MD, PhD University of Pittsburgh Medicine and Cell Biology & Physiology

Alexander Sorkin, PhD University of Pittsburgh Department of Cell Biology

Julia Kofler, PhD University of Pittsburgh Department of Neuropathology

Claudette St. Croix, PhD University of Pittsburgh Department of Environmental and Occupational

Health

Simon Watkins, PhD University of Pittsburgh Center for Biologic Imaging

Charleen Chu, MD, PhD University of Pittsburgh Department of Neuropathology

R. Mark Richardson, MD University of Pittsburgh Department of Neurosurgery

Michael Palladino, PhD Univeristy of Pittsburgh Department of Pharmacology

Yvette Conley, PhD University of Pittsburgh School of Nursing

Douglas Kondziolka, MD University of Pittsburgh Department of Neurosurgery

Kari Fladmark, PhD University of Bergen, Norway

Ole Isacson, PhD Harvard Medical School

J. Marie Hardwick, PhD Johns Hopkins University

Fernando Pineda, PhD Johns Hopkins University

102

Edward Burton, MD, DPhil, FRCP

J. T. Greenamyre, MD, PhD University of Pittsburgh Department of Neurology and PIND

Sarah Berman, MD, PhD University of Pittsburgh Department of Neurology and PIND

Simon Watkins, PhD University of Pittsburgh Center for Biologic Imaging

Goetz Veser, PhD University of Pittsburgh Department of Chemical Engineering

Claudette St. Croix, PhD University of Pittsburgh Center for Biologic Imaging

Oliver Bandmann, MD, PhD University of Sheffield, UK

Bennet Van Houten, PhD University of Pittsburgh Department of Phamacolog and Chemical

Biology and UPCI

Patricia Opresko, PhD University of Pittsburgh, Department of Environmental and Occupational

Health and UPCI

Marcel Bruchez, PhD Carnegie Mellon University

Franca Cambi, MD, PhD

Haining Zhu, PhD

University of Kentucky, Department of Biochemistry

Quasar Padiath, PhD University of Pittsburgh, Department of Human Genetics

Mandy McGeachy, PhD University of Pittsburgh, Department of Medicine

Guodong Cao, PhD

Xiaoming Hu, MD University of Pittsburgh Department of Neurology

Rehana Leek Duquesne University

Feng Zhang University of Pittsburgh Department of Neurology

Yanqin Gao University of Pittsburgh Department of Neurology

Jun Chen, MD University of Pittsburgh Department of Neurology

Dandan Sun University of Pittsburgh Department of Neurology

Yumin Luo Capital Medical Univeristy, China

Edward Dixon Univeristy of Pittsburgh

Jian Xiao Wenzhou Medical University, China

Xunming Ji Capital Medical University, China

Jun Chen, MD

Steven Graham, MD, PhD University of Pittsburgh Department of Neurology

Tim Greenamyre, MD, PhD University of Pittsburgh Department of Neurology

Dandan Sun, MD, PhD University of Pittsburgh Department of Neurology

Yanqin Gao, MD Fudan University, State Key Laboratory of Medical Neurobiology

Xunming Ji, MD, PhD Beijing Capital Medical University, Xunwu Hospital

Yun Xu, MD, PhD Nanjing University, Department of Neurology

Guodong Cao, PhD University of Pittsburgh Department of Neurology

C. Edward Dixon, PhD University of Pittsburgh Department of Neurosurgery

Robert M. Friedlander, MD University of Pittsburgh Department of Neurosurgery

Stephen F. Badylak, DVM, PhD, MD University of Pittsburgh Department of Pathology

Jailing Liu, PhD University of California at SF

Rehana Leak, PhD Duquesne University

Baoliang Sun, MD Shangdong University

Michael Bennett, D.Phil Albert Einstein College of Medicine

103

Paula Clemens, MD

Paul Robbins, PhD The Scripps Research Institute, Jupiter, Florida

Hoda Abdel-Hamid, MD University of Pittsburgh Department of Pediatric Neurology

Sasa Zivkovic, MD University of Pittsburgh Department of Neurology

Denis Guttridge, PhD Ohio State University Department of Molecular Virology, Immunology &

Medical Genetics

CINRG investigators Children’s National Medical Center and other institutions

Dana Ascherman, MD, PhD University of Florida, Miami, Florida

Eric Hoffman, PhD Children’s National Medical Center, Washington, DC

Kanneboyina Nagaraju, PhD Children’s National Medical Center, Washington, DC

Yetrib Hathout, PhD Binghamton Univrsity, Minghamton, NY

Araya Puwanant, MD University of Pittsburgh, Department of Neurology

Roxanna Bendixen, PhD University of Pittsburgh, Department of Occupational Therapy

Jan Drappatz, MD

Nduka Amankulor, MD University of Pittsburgh Department of Neurosurgery

Johnathan Engh, MD University of Pittsburgh Department of Neurosurgery

Paula Sherwood University of Pittsburgh School of Nursing

Brian Alexander, MD, MPH Dana-Farber Cancer Institute, Harvard University

Kathy Gardner, MD

Catalina Cleves, MD Children’s Hospital of Pittsburgh

Inna Vaisleib, MD Children’s Hospital of Pittsburgh

Amy Goldstein, MD Children’s Hospital of Pittsburgh

Monica Naik, MD Children’s Hospital of Pittsburgh

Robert Kaniecki, MD University of Pittsburgh Department of Neurology Headache Center

Barbara Vogler, MD University of Pittsburgh Department of Neurology Headache Center

Claire Yanta, MD University of Pittsburgh Department of Neurology Headache Center

Michael Barmada, PhD University of Pittsburgh Department of Human Genetics

Steven H. Graham, MD, PhD

Jun Chen, MD University of Pittsburgh Department of Neurology

Patrick Kohanek, MD University of Pittsburgh Department of Critical Care Medicine

C. Edward Dixon PhD University of Pittsburgh Department of Neurology

Sam Poloyak, PhD University of Pittsburgh School of Pharmacy

Valerian Kagan, PhD

University of Pittsburgh Department of Occupational and Environmental

Health

Robert Clark, MD University of Pittsburgh Department of Critical Care Medicine

Robert Hickey MD University of Pittsburgh Department of Pediatrics

German Barrioneuva University of Pittsburgh Department of Neuroscience

J. Timothy Greenamyre, MD PhD

Sarah Berman University of Pittsburgh Department of Neurology

Teresa Hastings University of Pittsburgh Department of Neurology

104

Teresa Hastings, PhD

Jun Chen, MD University of Pittsburgh Department of Neurology

Sarah Berman, MD, PhD University of Pittsburgh Department of Neurology

Edward Burton, MD, DPhil, FRC University of Pittsburgh Department of Neurology

J. T. Greenamyre, MD, PhD University of Pittsburgh Department of Neurology

Guodong Cao, PhD University of Pittsburgh Department of Neurology

Valerian Kagan, PhD University of Pittsburgh Department of Environmental and

Occupational Health

Charleen Chu, MD, PhD University of Pittsburgh Department of Pathology

Rock Heyman, MD

Christopher Chermansky University of Pittsburgh Department of Urology

Quasar S. Padiath University of Pittsburgh Department of Human Genetics

Gulay Alper University of Pittsburgh Department of Pediatrics

David Levinthal University of Pittsburgh Department of Medicine (Gastroenterology)

Eric Hoffman, PhD

Emily Rocha, PhD University of Pittsburgh Department of Neurology

Roberto DiMaio, PhD University of Pittsburgh Department of Neurology

Chris Bodle, PhD University of Pittsburgh Department of Neurology

Xiaoming Hu, MD

Yanqin Gao Fudan University, State Key Laboratory of Medical Neurobiology and

Institute of Brain Sciences

Rehana Leak, PhD Duquesne University, Myland School of Pharmacy

Binfeng Lu, PhD University of Pittsburgh, Department of Immunology

Angus W. Thomson, PhD University of Pittsburgh, Starzl Transplantation Institute, Department

of Surgery

Jun Chen, MD University of Pittsburgh, Department of Neurology

Michael VL. Bennett, D.Phil Albert Einstein College of Medicine, Department of Neuroscience

Frank Faraci, PhD University of Iowa Carver College of Medicine, Department of Internal

Medicine and Pharmacology

105

Ed Burton University of Pittsburgh Department of Neurology

Robert Friedlander University of Pittsburgh Department of Neurosurgery

Don DeFranco University of Pittsburgh Department of Pharmacology

Charleen Chu University of Pittsburgh Department of Neuropathology

Max Hammer, MD

Tudor Jovin, MD University of Pittsburgh, Department of Neurology

Marlene Behrman, MD Carnegie Mellon, Neuropsychology

Kees Polderman, MD University of Pittsburgh, Department of Critical Care

Milos Ikonomovic, MD

Robert Sweet, MD, PhD

University of Pittsburgh Department of Psychiatry

William Klunk, MD, PhD University of Pittsburgh Department of Psychiatry

Chester Mathis, PhD University of Pittsburgh Department of Radiology

Patrick Kochanek, MD, PhD

University of Pittsburgh Department of Anesthesiology

Edward Dixon, PhD University of Pittsburgh Department of Neurosurgery

Katsuyoshi Mizukami, MD University of Tsukuba Department of Psychiatry, Japan

Elliott Mufson, PhD Rush University Medical Center Department of Neurological Sciences

Stephen Scheff, PhD University of Kentucky

Teresa Gomez-Isla, MD Massachusetts General Hospital, Department of Neurology

Bernardino Ghetti, MD Indiana University School of Medicine, Department of Pathology

Anthony Kline, PhD University of Pittsburgh Department of PhysMed and Rehabilitation

Ben Handen, PhD University of Pittsburgh Department of Psychiatry

Matthew Harper, PhD Iowa City VA Medical Center, Neurobiology

Alberto Valzquez, PhD Univeristy of Pittsburgh Department of Radiology

Ashutosh Jadhav, MD, PhD

Tudor Jovin, MD University of Pittsburgh Department of Neurology

Maxim Hammer, MD University of Pittsburgh Department of Neurology

Lawrence Wechsler, MD University of Pittsburgh Department of Neurology

Matthew Starr, MD University of Pittsburgh Department of Neurology

Bradley Molyneaux, MD, PhD University of Pittsburgh Department of Neurology

Brian Jankowitz, MD University of Pittsburgh Department of Neurosurgery

Brad Gross, MD University of Pittsburgh Department of Neurosurgery

Chris Martin-Gill, MD University of Pittsburgh Department of Emergency Medicine

Frank Guyette, MD University of Pittsburgh Department of Emergency Medicine

Samay Jain, MD

Tim Greenamyre, MD, PhD University of Pittsburgh Department of Neurology

Stuart Steinhauer University of Pittsburgh Department of Psychiatry

S. Studenski University of Pittsburgh Department of Medicine

David Lacomis, MD University of Pittsburgh Department of Neurology

Elsa Strotmeyer University of Pittsburgh Department of Epidemiology

Anne Newman University of Pittsburgh Department of Epidemiology

Hazem Samy University of Pittsburgh Department of Ophthalmology

Peter Gianaros University of Pittsburgh Department of Psychiatry

Max Levine Siena College Department of Psychology

Thanh Ton University of Washington Department of Epidemiology

Will Longstreth University of Washington Department of Neurology

Elan D. Louis Neurological Institute, Columbia University Medical Center

Evan Thacker University of Washington Department of Epidemiology

106

Sirwan Darweesh University Medical Center Rotterdam

Seo Young Park University of Pittsburgh Department of Medicine

Dorothy K. Sit University of Pittsburgh Western Psychiatric Institute

Danielle Normolle University of Pittsburgh

David Goldstein National Institutes of Health

Peter LeWitt Henry Ford Hospital

Margaret Schenkman University of Colorado Denver Department of Physical Medicine and

Rehab

Douglas Landsittel University of Pittsburgh Center for Research on Health Care Data

Thomas H. Mosley, Jr. University of Mississippi Medical Center

Sudha Seshadri Boston University

Alvaro Alonso University of Minnesota

Mary Lou Biggs University of Washington

Honglei Chen National Institutes of Health

Joseph C. Delaney University of Washington

Sam Frank Boston University

Daniel Corcos University of Illinois at Chicago

Robert Hauser University of South Florida

Alexa Beiser Boston University

Tudor Jovin, MD

Lawrence Wechsler, MD University of Pittsburgh Department of Neurology

David Lacomis, MD

Christopher Donnelly University of Pittsburgh Brain Institute

Andrew Schwartz University of Pittsburgh Brain Institute

Peter Strick University of Pittsburgh Brain Institute

Chester Oddis University of Pittsburgh Department of Rheumatology

Robert Friedlander University of Pittsburgh Department of Neurosurgery

Diane Carlisle University of Pittsburgh Department of Neurosurgery

Rohit Aggarwal University of Pittsburgh Division of Rheumatology

Steve Meriney University of Pittsburgh Department of Neuroscience

Frank Lieberman, MD

Paula Sherwood University of Pittsburgh Department of Acute Tertiary Nursing

James Mountz University of Pittsburgh Department of Radiology

Hideho Okada University of Pittsburgh Department of Neurological Surgery

Ian Pollack University of Pittsburgh Department of Neurological Surgery

Hao Liu, MD, PhD

Steven H. Graham, MD, PhD University of Pittsburgh Department of Neurology

Robert W. Hickey, MD University of Pittsburgh, Department of Pediatrics

107

Oscar Lopez, MD

Cyrus Raji University of California-Los Angeles, Department of Radiology

Paul Thompson University of California-LA Departments of Radiology and Neurology

Debby Tsuang University of Washington, Seattle

Merce Boada i Rovira Fundació ACE, Barcelona, Spain

Annette Fitzpatrick University of Washington, Seattle

James Leverenz Cleveland Clinic

Sudha Seshardi Boston University

Lenore Launer National Institute on Aging

Maike Janssen Harvard University

Lazarus Mayoglou, DO

Sasha Dionisio, md Mater Center for Neurosciences, S Brisbane, QLD

Sung-Min Cho, MD

Bradley Lega, MD, PhD UT Southwestern Medical Center

David Prime, BEng

Patrick Flanigan, MD Neurological Surgery, Greensburg, PA

Richard Leahy, MD, PhD Univeristy of Souther California, Los Angeles

Jorge Gonzalez-Martinez, MD, PhD Cleveland Clinic

Dileep Nair, MD Cleveland Clinic

John Mosher, PhD Cleveland Clinic

Bradley Molyneaux, MD, PhD

Jon Rittenberger, MD

University of Pittsburgh Emergency Medicine

Taylor Kimberly, MD, PhD Massachusetts General Hospital

Clifton Callaway, MD, PhD University of Pittsburgh Emergency Medicine

Dimitrios Nacopoulos, MD

ZA Ahmed

S. John

N. Papesh

D. Levine

C. Bamford

Jullie Pan, PhD

Ruben Kuzniecky, MD New York University School of Medicine

Oded Gonen, PhD New York University School of Medicine

T. Kevin Hitchens, PhD Carnegie Mellon University

Araya Puwanant, MD

Paula Clemens, MD University of Pittsburgh Department of Neurology

Robert Griggs, MD University of Rochester Department of Neurology

Charles Thornton, MD University of Rochester Department of Neurology

Susan Greenspan, MD University of Pittsburgh Department of Medicine

Cynthia Britton, MD University of Pittsburgh Department of Radiology

108

Gwendolyn Sowa, MD, PhD University of Pittsburgh Department of Physical Medicine and

Rehabilitation

Sara Piva, PhD Univeristy of Pittsburgh, School of Health and Rehabilitation Sciences

Peggy Nopoulos, MD University of Iowa, Department of Psychiatry

Ami Mankodi, MD NIH/Neurogenetics Branch

Vivek Reddy, MD

Maxim Hammer, MD University of Pittsburgh Department of Neurology

Tudor Jovin, MD University of Pittsburgh Department of Neurology

Marcelo Rocha, MD, PhD

Jun Chen, MD University of Pittsburgh Department of Neurology

Tudor Jovin, MD University of Pittsburgh Department of Neurology

Kejie Yin, MD, PhD Univeristy of Pittsburgh Department of Neurology

Sherry Chou, MD University of Pittsburgh Department of Neurology

Bradley Molyneaux, MD, PhD University of Pittsburgh Department of Neurology

Sruti Shiva, PhD University of Pittsburgh Department of Pharmacology

Clifton Callaway, Md, PhD University of Pittsburgh Department of Emergency Medicine

Timothy Greenamyre, MD, PhD University of Pittsburgh Department of Neurology

Lori Shutter, MD, FCCM, FNCS

David Okonkwo, MD, PhD

University of Pittsburgh Department of Neurology

Cliff Callaway, MD University of Pittsburgh Department of Emergency Medicine

Jon Rittenberger, MD University of Pittsburgh Department of Emergency Medicine

Marilyn Hravnak, PhD, RN University of Pittsburgh, School of Nursing

Beth Snitz, PhD

Oscar Lopez, MD University of Pittsburgh Department of Neurology

William Klunk, PhD, MD University of Pittsburgh Department of Psychiatry

Mary Ganguli, MD University of Pittsburgh Department of Psychiatry

James Becker, PhD University of Pittsburgh Department of Psychiatry

Chester Mathis, PhD University of Pittsburgh Department of Radiology

Howard Aizenstein, MD, PhD University of Pittsburgh Department of Psychiatry

Neelesh Nadkarni, MD University of Pittsburgh Department o fMedicine,Geriatric Medicine

Division

Joyce Chang, PhD University of Pittsburgh Department of Medicine

Josif Stakic, MD

Ajitesh Ojha, MD University of Pittsburgh Department of Neurology

Robert Kaniecki, MD University of Pittsburgh Department of Neurology

Matthew Starr, MD

Ashu Jadhav, MD University of Pittsburgh Department of Neurology

Tudor Jovin, MD University of Pittsburgh Department of Neurology

Samir Saba, MD University of Pittsburgh Department of Cardiology

Robert Kormos, MD University of Pittsburgh Department of Cardiology

109

Ruth Anne Stetler, PhD

Rehana K. Leak, PhD Duquesne University

Yanqin Gao, MD Fudan University

Michael Bennett, PhD Albert Einstein

Jana Kainerstorfer, PhD Carnegie Mellon Univeristy

Michelle Stevens, DO

Erica Grazioli, DO University of Pittsburgh Medical Center - Hamot

Dandan Sun, MD, PhD

Ed Dixon, PhD University of Pittsburgh

Elias Aizenman, PhD University of Pittsburgh

Jun Chen, MD, PhD University of Pittsburgh

Seth Alper, MD, PhD Harvard Medical School

Kevin Hutchins, PhD Carnegie Mellon University

Vitorrio Gallo, PhD National Children’s Hospital

Guodong Cao, PhD University of Pittsburgh Department of Neurology

John Kuo, MD, PhD University of Wisconsin-Madison

Kris Kahle, MD, PhD Harvard Medical School

Jane Wang, PhD University of Pittsburgh

Xiangqun Xie, PhD University of Pittsburgh

Tija Jacob, PhD University of Pittsburgh

Anders Persson, PhD University of California – San Fransisco

Gary Kohanbash University of Pittsburgh

Maria Castro University of Michigan

Eric Delpire, PhD Vanderbilt University

Alexandra Urban, MD

Jon Rittenberg, MD, MS University of Pittsburgh Department of Emergency Medicine

Anto Bagic, MD, MS University of Pittsburgh Department of Neurology

Jullie Pan, MD, PhD University of Pittsburgh Department of Neurology

Arun Antony, MD University of Pittsburgh Department of Neurology

Rick Hendrickson, PhD University of Pittsburgh Department of Neurology

Maria Baldwin, MD University of Pittsburgh Department of Neurology

Gena Ghearing, MD University of Pittsburgh Department of Neurology

Mark Richardson, MD University of Pittsburgh Department of Neurosurgery

A. Ghuman, PhD University of Pittsburgh Department of Neurosurgery

Jonathan Elmer, MD University of Pittsburgh Department of Emergency Medicine

Anne Van Cott, MD

Mary Jo Pugh, RN, PhD University of Texas Health Science Center

Hoby Hetherington, MD University of Pittsburgh Amy Wagner, MD University of Pittsburgh

110

Zongqi Xia, MD, PhD -

Sergio Baranzini, PhD International Multiple Sclerosis Microbiome Study Consortium

Philip De Jager, MD, PhD Brigham and Women’s Hospital, Broad Institute

Daniel Reich, MD, PhD National Institute of Neurological Disorders and Stroke

Amar Dhand, MD, DPhil Brigham and Women’s Hospital

Guergana Savova, PhD Boston Children’s Hospital

Tianxi Cai, ScD Harvard School of Public Health

David Whitcomb, MD, PhD University of Pittsburgh, Department of Cell Biology and Physiology

Shyam Visweswaran, MD, PhD University of Pittsburgh, Department of Biomedical Informatics

Kayhan Batmanghelich, PhD University of Pittsburgh, Department of Biomedical Informatics

Joseph Mettenburgh, MD, PhD University of Pittsburgh, Department of Radiology

Ashok Panigraphy, MD University of Pittsburgh, Department of Radiology

Bennett Landsman, PhD Vanderbilt University

Brian Kolowitz, DSc, MSc, MBA University of Pittsburgh Medical Center Enterprise

Tingting Zhang, PhD Brown University

Helen Tremlett, PhD University of British Columbia

John Corboy, MD University of Colorado Denver

Darren Okuda, MD University of Texas Southwestern

Tamer Ibrahim, PhD Univeristy of Pittsburgh

Lawrence Wechsler, MD

Robert Hobson, MD University of Medicine and Dentistry New Jersey

Daniel Hanley, MD Johns Hopkins University

Paula Clemens, MD University of Pittsburgh School of Medicine Department of Neurology

Clifton Callaway, MD, PhD University of Pittsburgh School of Medicine Department of

Emergency Medicine

Maarten Lansberg, MD, PhD Stanford University Medical Center

Kejie Yin, MD, PhD

Eugene Chen, MD, PhD University of Michigan Vascular Medicine

Jun Chen, MD University of Pittsburgh Department of Neurology

Bruce A. Freeman, PhD University of Pittsburgh Department of Pharmacology

Naoir Zaher, MD

Arun Antony, MD Univeristy of Pittsburgh Department of Neurology

Alexandra Urban, MD University of Pittsburgh Department of Neurology

Islam Zaydan, MD

Robert Friedlander, MD University of Pittsburgh Department of Neurosurgery

Juan Fernandez-Miranda, MD University of Pittsburgh Department of Neurological Surgery

Gabrielle Bonhomme, MD University of Pittsburgh Department of Ophthalmology

Feng Zheng, MD, PhD

Jun Chen, MD University of Pittsburgh Department of Neurology

Guodong Cao, PhD University of Pittsburgh Department of Neurology

111

Yanqin Gao, PhD Fudan University State Key Lab of Neurobiology

R. Anne Stetler, PhD University of Pittsburgh Department of Neurology

Rehana K. Leak, PhD Duquesne University School of Pharmacy

Baoliang Sun, MD, PhD Tanshan Medical University

Richard F. Keep, PhD University of Michigan, Department of Neurosurgery

Xunming Ji, MD, PhD Xuanwu Hospital, Capital Medical University

Michael Zigmond, PhD

Judy Cameron, PhD University of Pittsburgh Department of Psychiatry

Barry Hoffer, PhD Case Western Reserve University

Jun Chen, MD University of Pittsburgh Department of Neurology

Jan Cavanaugh, PhD Duquesne University

Beth Fischer, PhD University of Pittsburgh Department of Family Medicine

Adrian Michael, PhD University of Pittsburgh Department of Chemistry

Karoly Mirnics, MD Vanderbilt University

Richard Smeyne, PhD St. Jude Children’s Hospital

Sasa Zivkovic, MD

Prem Soman, MD, PhD University of Pittsburgh, Division of Cardiology

Elsa Strotmeyer, PhD University of Pittsburgh Graduate School of Public Health

Michal Vytopil, MD, PhD Lahey Hospital and Medical Center, Burlington, MA

Ahmed El-Dokla, MD Texas Tech University

Suzanne Lentzsch, MD PhD Pittsburgh Cancer Institute

Elsa Strotmeyer, PhD University of Pittsburgh Graduate School of Public Health

112

Faculty Honors, Editorial Service, and Professional Affiliations

Puja Aggarwal, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Epilepsy Society

Arun Antony, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Epilepsy Society

Society for Neuroscience

Anto Bagic, MD, PhD

Editorial Service

Editorial Board Member: Journal of Clinical Neurophysiology

Ad hoc reviewer

American Journal of Neuroradiology Epilepsy & Behavior Brain Research Epilepsy Research

Case Reports in Neurology Journal of Neuroimaging

Clinical Neurophysiology Journal of Clinical Neurophysiology Croatian Medical Journal Seizure

Epilepsia

Membership in Professional and Scientific Societies

National and International

American Academy of Neurology (AAN)

American Clinical MEG Society (ACMEGS)

American Clinical Neurophysiology Society (ACNS)

American Epilepsy Society (AES)

American Medical Association

International Society for the Advancement of Clinical MEG (ISACM) Executive Committee

National Association of Epilepsy Centers, Board of Directors,

University and Medical School

Clinical Neurophysiology Fellowship Committee, Department of Neurology

Clinical Productivity Incentive Plan Committee, Department of Neurology

Clerkship Committee, Department of Neurology

Sarah Berman, MD, PhD

Honors

Selected Best Doctors of America 2017

Editorial Service

Ad hoc reviewer

American Journal of Pathology Journal of Neurochemical Research

Antioxidants & Redox Signaling Journal of Vestibular Research Autophagy Journal of Visualized Experiments

Biochimica et Biophysica Acta – Molecular Basis of Disease Mitochandrion

113

Cell Death and Differentiation Molecular Cell

Human Molecular Genetics Nature Reviews - Neuroscience

Journal of Biological Chemistry Neurobiology of Disease

Journal of Neurochemistry Neuroscience Journal of Neuroscience Neuroscience Letters

PLOS One

Membership in Professional and Scientific Societies

American Academy of Neurology

American Neurological Association

Movement Disorders Society

Parkinson Study Group

Society for Neuroscience

Edward Burton, MD, DPhil, FRCP

Honors

2017 Pittsburgh Magazine, Listed as one of the Top Doctors in the region for neurology

Editorial Service

Ad hoc reviewer

PLOS One

Brain Human Molecular Genetics

Neurobiology of Disease

The Journal of Neuroscience Reviewing Editor starting in 2015

The Journal of Biological Chemistry

Membership in Professional and Scientific Societies

American Neurological Association-Fellow

American Society for Biochemistry and Molecular Biology

Association of British Neurologists

Movement Disorders Society

Royal College of Physicians of London-Fellow

The Society for Neurosciences

Neil Busis, MD

Editorial Service

Editorial Board, Medscape Reference, Neurology (wwwURL:http://emedicine.medscape.com/neurology)

Editorial Board, Neurology Today

Ad hoc reviewer

Archives of Neurology Medscape General Medicine

Clinical Neurophysiology Muscle & Nerve

European Journal of Neurology Neurology

Journal of Neurology, Neurosurgery, and Psychiatry Neurology: Clinical Practice Journal of the American Medical Association The Neurologist

Journal of the Neurological Sciences

114

Memberships in Professional and Scientific Societies

Allegheny County Medical Society (PA)

American Academy of Neurology

American Association for the Advancement of Science

American Association of Neuromuscular & Electrodiagnostic Medicine

American Clinical Neurophysiology Society

American College of Physicians / American Society of Internal Medicine

American Medical Association

American Medical Informatics Association

Neurocritical Care Society

Neurohospitalist Society

PA Medical Society

PA Neurological Society

Stroke Council of the American Heart Association

Society for Neuroscience

The Internet Society

World Muscle Society

Franca Cambi, MD, PhD

Editorial Service

Grant Review

European Leukodystrophy Association (ELA Foundation)

Ministere de la Recherche, France

French National Research Agency (ANR)

National Multiple Sclerosis Society (NMSS)

National Science Foundation

Ad hoc reviewer

American Journal of Medical Genetics Journal of Neurological Sciences

Annals of Neurology Journal of Neuroscience

Current Medicinal Chemistry Journal of Pediatrics European Journal of Human Genetics Neurology

Experimental Journal of Human Genetics Plos One

Glia Human Mutation

Membership in Professional and Scientific Societies

American Academy of Neurology

American Society for Neurochemistry

Nominated American Neurological Association

Society for Neuroscience

Erin Canale, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Epilepsy Society

115

Guodong Cao, PhD

Editorial Service

Editorial Boards

Aging and Disease Annals of Neurological Surgery

Asian Journal of Neuroscience

Austin Aging Research Brain Circulation

Current Research in Stem Cell and Regenerative Medicine Geriatric Medicine & Palliative Care (GMPC)

International Journal of Neurology and Neurological Disorders

Journal of Cerebral Blood Flow and Metabolism Journal of eNeurologicalSci

Journal of Neurology and Experimental Neural Science

Neurological Disorders & Epilepsy Journal

Open Access Journal of Neurology

Prime Research in Neurological Disorders SM Neurodegenerative Disorders

SRL Brain Disorders & Therapy

Reviewer Committee, Neural Regeneration Research

Ad hoc reviewer

Advance in Neuroscience Annals of Neurology Neurobiology of Disease

Brain Research Neuroscience Letters

Cell Death and Differentiation Neurochemical International CNS Neuroscience and Therapeutics Neurochemical Research

Critical Care Medicine Neuropharmacology Drug Delivery Letters Neurochemistry International

European Journal of Pharmacology Neuroscience

Journal of Cerebral Blood Flow and Metabolism Neurotoxicity Research Journal of Neuroscience Pediatric Research

Journal of Neurochemistry PLOS One

Journal of Neurological Science Progress in Neurobiology Molecular Biology Reports Stem Cell

Neural Regeneration Research The Open Drug Discovery Scientific Report Translational Stroke Research

Molecular Therapy

Membership in Professional and Scientific Societies

International Society for Cerebral Blood Flow & Metabolism

Society for Neuroscience

Jun Chen, MD

Honors -

RK Mellon Endowed Chair for Cerebrovascular Disease Research, University of Pittsburgh 2008-

Sr Research Career Scientist Award, VA Medical Center

Changjiang Chair Professorship, Chinese Education Commission

Outstanding Oversea Researcher, Chinese Natural Science Foundation, China

116

Editorial Service

Editorial Board Member

Editor-in-Chief: Journal of Cerebral Blood Flow and Metabolism

Associate Editor, Translational Stroke Research Associate Editor, CNS Neuroscience & Therapeutics

Associate Editor and Handling Editor: Scientific Reports

Associate Editor and Handling Edior: Neurobiology of Disease CNS Neurological Disorders – Drug Targets

CNS Neurological Disorders – Clinical Drugs Journal of Cerebral Blood Flow and Metabolism

Neurobiology of Disease

Neurotherapeutics Progress in Neurobiology

Stroke Guest Editor and handling: Special Issue in Progress in Neurobiology

Guest Editor and handling: Special Issue in Neurobiology of Disease

Ad hoc reviewer American Journal of Pathology

Annals of Neurology

Bio Techniques Brain Research

Cell Death and Differentiation Circulation

Circulation Research

European Journal of Neuroscience European Journal of Pharmacology

Experimental Neurology Gene Therapy

Glia

Journal of Biological Chemistry Journal of Cell Biology

Journal of Cerebral Blood Flow and

Metabolism Journal of Clinical Investigation

Journal of Neurochemistry

Journal of Neuroscience

Molecular Brain Research Molecular Neurobiology

Molecular Therapy Nature Medicine

Nature Neuroscience

Neurobiology of Aging Neurobiology of Disease

Neurochemistry International Neuroscience

Neuroscience Letters

Neuroscience Research Nucleotide Acid Research

PNAS USA

Progress in Neurobiology Stroke

Membership in Professional and Scientific Societies -

American Heart Association Stroke Counsul

International Society for Cerebral Blood Flow and Metabolism

International Society of Translational Stroke Research

Society for Neuroscience

Professional Affiliations

Treasurer, International Society of Cerebral Blood Flow & Metabolism

Paula Clemens, MD

Editorial Service

Ad hoc reviewer

American Journal of Human Genetics Molecular Therapy Annals of Neurology Muscle & Nerve

BBA Molecular Basis of Disease Nature Biotechnology

117

Gene Therapy Neurology

Genome Research Neuroscience

Human Gene Therapy PLOS One Journal of Genetic Counseling Science Translational Medicine

Journal of Neurological Sciences The Journal of Gene Medicine

Kidney International Lancet Neurology

Membership in Professional and Scientific Societies

American Academy of Neurology

American Neurological Association

James DeMatteis, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Society of Neuro Rehabilitation

John Doyle, MD

Honors

Honored at the Honors Convocation University of Pittsburgh for Leadership in Medical Education 2017

Membership in Professional and Scientific Societies

American Academy of Neurology

Jan Drappatz, MD

Honors

Above and Beyond Award, UPMC, 2016

Best Doctors, 2017

Best of Pittsburgh, 2017

Castel Connolly Top Doctors, 2017

Compassionate Caregiver Award, Vitals, 2016

Editorial Service

Abstract Reviewer – Society of Neuro-Oncology Meeting

Ad Hoc Reviewer-

BMC Cancer International Journal of Radiation Oncology, Biology,

British Journal of Cancer Physics

Clinical Cancer Research Journal of Clinical Oncology Drug Discovery Today Journal of Neuro-Oncology

Drug Target Insights Medical Science Monitor Expert Reviews of Anticancer Therapy Neuro-Oncology

Future Oncology Neuropsychiatric Disease and Treatment

Membership in Professional and Scientific Societies-

Alliance for Clinical Trials in Oncology

American Academy of Neurology

American Association for Cancer Research

American Society of Clinical Oncology

International Primary Central Nervous System Lymphoma Collaborative Group

Society for Neuro-Oncology

118

Jeffrey Esper, DO, MS, (Med Ed)

Membership in Professional and Scientific Societies

American Association of Neuromuscular and Electrodiagnostic Medicine, Fellow

American College of Osteopathic Neurology and Psychiatry

Joanna Fong, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Academy of Sleep Medicine

American Epilepsy Society

Kathy Gardner, MD

VAPHS Service

Scan Echo Project for Headache Teaching Slides

Joint Pain Education Program/Defense & Veterans Center for Integrative Pain Management; Tier 2

teaching slides and headache expert reviewer

VA Women’s Health Choosing Wisely Taskforce member developing headache teaching slides

Membership in Professional and Scientific Societies

American Academy of Neurology

American Headache Society

American Society of Human Genetics

International Headache Society

Society of Neuroscience

Gena Ghearing, MD

Editorial Service

Ad hoc reviewer

Epilepsia

International Journal of Neural Systems

Neurology

Membership in Professional and Scientific Societies

Allegheny County Medical Society

American Academy of Neurology

American Clinical Neurophysiology Society

American Epilepsy Society

American Medical Association

Pennsylvania Medical Association

Steven Graham, MD, PhD

Editorial Service

Editorial Board

J. Cerebral Blood Flow and Metabolism

119

Ad hoc reviewer

Annals of Neurology Molecular Brain Research

Brain Research Molecular Neurobiology Brain Pathology Neurobiology of Disease

European Journal of Neuroscience Neuroscience

Experimental Neurology Neuroscience Letters F.A.S.E.B. Journal Neurochemical Research

Gene Therapy Neurochemistry International

Journal of Histochemistry and Cytochemistry Progress in Neurobiology Journal of Neurochemistry Stroke

Journal of Neuroscience Journal of Neurotrauma

Journal of Pharmacology and Experimental Therapeutics

Grant Review -

National Institute of Health, Center for Scientific Review, BINP Study Section

Membership in Professional and Scientific Societies

American Academy of Neurology, Stroke Council

Gerontological Society of America

National Stroke Council, American Heart Association

Society for Neuroscience

Erica Grazioli, DO

Membership in Professional and Scientific Societies

American College of Osteopathic Neurologists and Psychiatrists

American Academy of Neurology

American Osteopathic Association

Consortium of Multiple Sclerosis Centers

J. Timothy Greenamyre, MD, PhD

Honors

Listed, Top Doctors in Pittsburgh, Castle Connolly 2017

Listed, Best Doctors in America 2017

Chair, Gordon Research Conference on Parkinson’s disease

Editorial Service

Editor-in-Chief, Neurobiology of Disease Editor-in-Chief, Medlink Neurology (www.medlink.com) online clinical resource

Consulting Editor for Journal of Clinical Investigation

Advisory Board, Functional Neurology Reviewing Editor, ASN-Neuro

Editorial Board, Journal of Parkinson’s Disease

Editorial Board, Neuropharmacology

Editorial Board, Basal Ganglia

Interspecialty Associate Editor, Neurosurgery

120

Ad hoc reviewer

American Journal of Human Genetics Journal of Neuroscience

American Journal of Physiology Journal of Neuroscience Research Annals of Neurology Journal of Neurophysiology

Archives of Neurology Journal of the Neurological Sciences

Behavioral Pharmacology J. Pharmacology and Experimental Therapeutics Biochemical Pharmacology The Lancet

Biochim Biophys Acta Life Sciences

Biological Psychiatry Mechanisms of Aging and Development Brain Molecular and Chemical Neuropathology

Brain Pathology Molecular Pharmacology Brain, Behavior and Immunity Molecular Therapeutics

Brain Research Movement Disorders

Cell Nature Cell Metabolism Nature Medicine

Clinical Neuropharmacology Nature Neuroscience

EMBO Molecular Medicine Neurobiology of Aging

Endocrinology Neurobiology of Disease

Epilepsy Research Neurodegeneration European Journal of Neuroscience Neurology

Experimental Brain Research Neuron

Experimental Neurology Neuropharmacology Free Radical Biology & Medicine Neuroscience

Human Molecular Genetics Neuroscience Letters Journal of Alzheimer’s Disease Neuro Toxicology

Journal of Biological Chemistry Parkinson’s Disease

Journal of Cell Science Physiology & Behavior Journal of Cerebral Blood Flow and Metabolism Proc. Natl. Acad. Of Science (U.S.A.)

Journal of Clinical Investigation Psychobiology Journal of Comparative Neurology Science

Journal of Experimental Medicine Science Translational Medicine

Journal of Neural Transmission Trends in Molecular Medicine Journal of Neurochemistry Trends in Pharmacological Sciences

Nature Reviews Neuroscience Analytical Chemistry

Cell Research

Ad hoc Grant Reviews

Alzheimer’s Association

Medical Research Council of Canada

Hereditary Disease Foundation

Huntington’s Disease Society of America

The Ontario Mental Health Foundation (Canada)

Alberta Heritage Foundation for Medical Research

U.S. Army / BioReview (NETRP-97)

North Carolina Biotech Center Science and Technology Development Program

Parkinson’s Disease Society, London, UK

121

Membership in Professional and Scientific Societies -

American Academy of Neurology

American Neurological Association

Association of American Physicians

Huntington Study Group

Movement Disorders Society

Parkinson Study Group

Society for Neuroscience

Maxim Hammer, MD

Editorial Service

Ad Hoc Reviewer

Stroke

Membership in Professional and Scientific Societies

American Academy of Neurology

American Heart Association Stroke Council

Teresa Hastings, PhD

Editorial Service

Handling Editor, Editorial Board Member for Journal of Neurochemistry

Editorial Board Member for Experimental Neurology

Ad hoc reviewer

Biochimica et Biophysica Acta Journal of Neurochemistry Experimental Neurology Journal of Neuroscience

Free Radical Biology and Medicine Neurobiology of Disease

Journal of Neurochemistry

Membership in Professional and Scientific Societies

American Academy for Advancement of Science

International Society for Neurochemistry

New York Academy of Sciences

Society for Free Radical Biology and Medicine

Society for Neuroscience

Rock Heyman, MD

Honors/Recognition

Best Doctors in America, Woodard/White, Inc.

Membership in Professional and Scientific Societies

American Academy of Neurology, Multiple Sclerosis Section

Consortium of Multiple Sclerosis Centers

Editorial Service

Ad hoc reviewer

International Journal of MS Care

122

Houman Homayoun, MD

Editorial Service

Ad hoc Reviewer

Brain Research Bulletin Neuropsychopharmacology Biological Psychiatry Neuroscience

International Journal of Neuropsychopharmacology Neuropharmacology Journal of Pharmacology and Experimental Therapeutics Psychopharmacology

Neurobiology of Disease

Membership in Professional and Scientific Societies

American Academy of Neurology

International Parkinson and Movement Disorder Society

Parkinson Study Group

Society for Neuroscience

Xiaoming Hu, MD, MS, PhD

Membership in Professional and Scientific Societies

American Heart Association

American Neurological Association

Society for Neuroscience

The International Society of Cerebral Blood Flow and Metabolism

Editorial Board

Journal of Clinical & Experimental Neuroimmunology

Editorial Service

Ad hoc reviewer

Annals of Neurology Journal of Neuroinflammation

Brain Research Neurobiology of Disease

CNS Neuroscience & Therapeutics Nutrition Research Journal of Cell & Molecular Medicine Stroke

Journal of Neuroinflammation The Journal of Cerebral Blood Flow & Metabolism

Translational Stroke Research Pro Natinal Academic Sci USA

Reviewer:

Internaitonal Symposiium on Cerebral Blood Flow, Metabolism and Function

Internaional Stroke Conference

Milos Ikonomovic, MD

Honors

January 2017 received The Christopher Clark Award – for continuing advancement in the field of human

amyloid imaging

Editorial Service

Associate Editor - Cardiovascular Psychiatry and Neurology

Review Editor - Neurotrauma

123

Ad hoc reviewer

Acta Neuropathologica Journal of Gerontology

Alzheimer’s & Dementia Journal of Neuropathology & Exper Neurol American Journal of Pathology Journal of Neurotrauma

Alzheimer Disease and Associated Disorders Nature

Annals of Neurology Neurobiology of Aging Archives of Neurology Neurotrauma

Brain Neurimage Clinical

Experimental Neurology Neurology Frontiers in Neurology Neuroscience

Journal of Alzheimer’s Disease PNAS Journal of Comparative Neurology

Grant reviewer

The Alzheimer’s Association International Research Grant Program

University of Pittsburgh Alzheimer Disease Research Center pilot grant review

Department Psychiatry Internal Review

VA Geriatric Research Education and Clinical Center (GRECC) Scientific Review

Membership in Professional and Scientific Societies

American Academy of Neurology

International Society to Advance Alzheimer Research and Treatment

National Neurotrauma Society

New York Academy of Sciences

Researchers Against Alzheimer’s

Society for Neuroscience & International Brain Research Organization

Ashutosh Jadhav, MD, PhD

Editorial Service

Associate Editor – Society for Vascular and Interventional Neurology Newsletter

Abstract Reviewer

American Stroke Association, International Stroke Conference

Ad hoc reviewer

Canadian Journal of Neurology

Journal of Neuroimaging Journal of Neurointerventional Surgery

The Neurologist

Membership in Professional and Scientific Societies

American Academy of Neurology

American Stroke Association

Society of Vascular and Interventional Neurology

Samay Jain, MD

Editorial Service

Guest Editor

Neurobiology of Disease

124

Ad Hoc Grant Reviews

VISN 4 Competitive Pilot Project Fund Medical Research Council

Western Psychiatric Institute and Clinic Research Committee

Editorial Board

The Neurohospitalist

Journal of the American Geriatrics Society Ad hoc reviewer

Case Reports and Clinical Practice Review Journal of American Geriatrics Society

Clinical Neurology and Neurosurgery Journal of Pediatric Neurology European Journal of Neurology Movement Disorders

Expert Review of Neurotherapeutics The American Journal of Managed Care International Journal of Psychophysiology The Neurohospitalist

Tremor & Other Hyperkinetic Movements Neuropsychiatric Disease and Treatment

Journal of Parkinson’s Disease Journal of Gerontology: Medical Sciences Journal of Parkinsonism & Restless Leg Syndrome Journal of Visualized Experiments

Journal of Geriatric Psychiatry and Neurology Journal of Human Hypertension

Journal of Neurology, Neurosurg & Psychiatry Parkinsonism & Related Disorders

Acta Neruologica Scandinavica Expert Opinion On Investigational Drugs

Membership in Professional and Scientific Societies

American Academy of Neurology

Movement Disorders Society

Ruchira Menka Jha, MD

Memberships in Professional and Scientific Societies

American Academy of Neurology

American Heart Association

Massachusetts Medical Society

Neurocritical Care Society

Society of Critical Care Medicine

Society for Neuroscience

Tudor Jovin, MD

Honor

Society of Vascular and Interventional Neurology Presidential Service Award

Editorial Service

Member, Editorial Board, Journal of Neuroimaging

Member, Editorial Board, Stroke

Member, Editorial Board, Interventional Neurology

Ad hoc reviewer Annals of Neurology Lancet Neurology

Circulation Neurology Journal of Endovascular Therapy Neurosurgery

Journal of Neuroimaging NINDS grant submissions

Journal of Neurointerventional Surgery Stroke Journal of Neurology Neurosurgery and Psychiatry

125

Membership in Professional and Scientific Societies

American Academy of Neurology

American Association of Neurological Surgeons

American Heart Association – Stroke Council

American Neurological Association

American Society of Neuroimaging

Society of Vascular and Interventional Neurology

World Stroke Organization

Robert Kaniecki, MD

Editorial Service

Assistant Editor, Headache Abstracts Editor, Headache

Ad hoc reviewer

Cephalalgia

Membership in Professional and Scientific Societies

American Academy of Neurology

American Headache Society

International Headache Society

Kelly Kay, DO

Membership in Professional and Scientific Societies

American Academy of Neurology

American Association of Neuromuscular and Electrodiagnostic Medicine

Pennsylvania Medical Society

Allegheny County Medical Society

Simin Khavandgar, MD

Membership in Professional and Scientific Societies

American Association of Sleep Medicine

American Academy of Neurology

Daniel Kinem, DO

Membership in Professional and Scientific Societies

American Academy of Neurology

American Osteopathic Association

Laurie Knepper, MD

Honors

2017 - Castle Connolly – Exceptional Women in Medicine

Best Doctors in Pittsburgh, Pittsburgh Magazine – 2017

Editorial Service

Reviewer - Journal of Stroke and Cerebrovascular Diseases Ad hoc Reviewer

Headache

126

Membership in Professional and Scientific Societies

American Academy of Medical Colleges (AAMC)

American Academy of Neurology

Headache subsection

Stroke subsection

American Headache Society

EMR/clinical informatics subsection

Headache Cooperative of New England

International Headache Society

David Lacomis, MD

Honors

“Top Doctors,” Pittsburgh Magazine, 2016

“America’s Top Doctors,” Castle Connolly Medical Ltd., 2016

“Best Doctors in America” (Woodward/White, Inc.), 2016

“America’s Most Honored Professionals Award – Top 5%,” American Registry, 2016

Editorial Service

Member, Editorial Board, Journal of Clinical Neuromuscular Diseases Section Editor, “What’s in the Literature?” Journal of Clinical Neuromuscular Diseases

Ad hoc reviewer:

Annals of Neurology Muscle and Nerve

Neurology

Membership in Professional and Scientific Societies -

American Academy of Neurology, Active Member, Fellow

American Association of Electrodiagnostic Medicine, Fellow

American Neurological Association, Fellow

Erek Lam, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Academy of Sleep Medicine

Mayo Clinic Alumni Association

Frank Lieberman, MD

Editorial Service

Ad hoc reviewer

Annals of Neurology Cancer Chemotherapy and Pharmacology

Clinical Cancer Research Journal of Neuroimaging

Lancet

Membership in Professional and Scientific Societies

American Association of Cancer Research

American Academy of Neurology – Neuro-Oncology Section

127

American Society of Clinical Oncology

Collaborative Ependymoma Research Network

ECOG-ACRIN: Biomarker Committee – CNS Tumor Committee

Radiation Therapy Oncology Group-CNS Tumors Committee

Society for Neuro-Oncology

Hao Liu, MD, PhD

Editorial Service

Ad hoc reviewer

Journal of Neuroscience Methods

PLOS One

Membership in Professional and Scientific Societies

American Society for Biochemistry and Molecular Biology (ASBMB)

International Society for Cerebral Blood Flow and Metabolism (ISCBFM)

Society for Neurosciences (SFN)

Oscar Lopez, MD

Honors

Endowed Chair: Levidow-Pittsburgh Foundation Endowed Chair in Alzheimer’s Disease and Dementia

Disorders

Honoree, University of Pittsburgh 41st Honors Convocation (2017)

Pittsburgh Magazine; Best Doctors in Town, Pittsburgh, PA (2017)

Editorial Service

Editorial Board, Neuropsychology Review, Associate Editor

Alzheimer’s & Dementia Translationa Research & Clinical Interventions

Alzheimer’s and Dementia. The Journal of the Alzheimer’s Association

European Neruology, Basel, Switzerland

Ad hoc reviewer

Alzheimer’s & Dementia

Annals of Neurology Biological Psychiatry

Circulation: Cardiovascular Quality & Outcomes

Cochrane DTA Human Brain Mapping

International Journal of Geriatric Psychiatry JAMA-Neurology

Journal of Alzheimer’s Disease

Journal of the American Geriatrics Society Lancet-Psychiatry

Nature: Scientific Reports

Neurobiology of Aging

Neurology

The American Journal of Psychiatry

128

Ad Hoc Grant Reviewer National Fund for Scientific and Technological Development (Fondo Nacional para el Desarrollo

Científico y Tecnológico -FONDECYT), Santiago, Chile

Vienna Science and Technology Fund (Wiener Wissenschafts- Forschungs- und

Technologiefonds), Vienna, Austria

National Agency of Research (Agence Nationale de la Récherche), Paris, France

The German Federal Ministry for Education and Research (BMBF), Berlin, Germany

NIH-National Institute on Aging – Neuroscience of Aging Review Committee

Angela Lu, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

Lazarus Mayoglou, DO

Membership in Professional and Scientific Societies

American Academy of Neurology

American Clinical Neurophysiology Society

American Epilepsy Society

American Osteopathic Association

James McLaughlin, DO, FACP, FAAN, FAHA

Honors

American Stroke Association/American Heart Association get with the guideline awards -Honor Roll

Elite Plus & Gold Plus – 2017

Memberships in Professional and Scientific Societies

American Academy of Neurology

American College of Physicians Fellowship

American Telemedicine Association

National Stroke Association

Edward Mistler, DO

Membership in Professional and Scientific Societies

American Academy of Neurology

American Osteopathic Association

Pennsylvania Medical Society

Bradley Molyneaux, MD, PhD

Editorial Service

Ad hoc reviewer

Journal of Neuroscience

129

Membership in Professional and Scientific Societies

American Academy of Neurology

American Heart Association

Neurocritical Care Society

Society for Neuroscience

Society of Critical Care Medicine

Dimitrios Nacopoulos, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

Movement Disorders Society

Parkinson’s Partners of Northwest PA, Medical Director

UPMC-Hamot Neurology Residence Assistant Director

Eric Ogren, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

Ajitesh Ojha, MD

Membership in Professonal and Scientific Societies

American Association of Neurology

American Association of Neuromuscular and Electrodiagnostic Medicine

The Neurophospitalist Society

Jullie Pan, MD, PhD

Editorial Service

Editorial Board - Magnetic Resonance in Medicine

MAGMA Journal of the European Society for Magnetic Resonance in Medicine and Biology

Membership in Professional and Scientific Societies

American Academy of Neurology

American Epilepsy Society

International Society for Magnetic Resonance in Medicine

International Society for Cerebral Blood Flow and Metabolism

Society for Neuroscience

Araya Puwanant, MD

Honors

NINDS Clinical Trail Methodology Course Award

Editorial Service

Ad hoc review

European Journal of Neurology European Neurology

Journal of the Neurological Sciences

International Journal of Neuroscience

130

Membership in Professional and Scientific Societies

American Academy of Neurology

American Association of Neuromuscular & Electrodiagnostic Medicine

American Neurological Society

New York Academy of Sciences

Vivek Reddy, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American College of Physician Executives

American Heart Association/American Stroke Association

American Medical Informatics Association

Association of Medical Directors of Information Systems

Marcelo Rocha, MD, PhD

Editorial Service

CNS Neuroscience & Therapeutics

Membership in Professional and Scientific Societies

American Academy of Neurology

American Stroke Association/AHA

Jingzi Shang, MD, PhD

Memberships in Professional and Scientific Societies

American Academy of Neurology

American Academy of Sleep Medicine

Pennsylvania Medical Society

Lori Shutter, MD, FCCM

Editorial Service

Periodicals

Critical Care Medicine Neurosurgery

Journal of Neurosurgery, Neurology and Psychiatry Neurocritical Care

Journal of Critical Care New England Journal of Medicine Journal of Neurotrauma

Membership in Professional and Scientific Societies

American Medical Association

American Academy of Neurology

National Neurotrauma Society

Neurocritical Care Society (NCS)

Congress of Neurological Surgeons

American Association of Neurological Surgeons

Society of Critical Care Medicine

Gold Humanism Honor Society

Western Neurosurgical Society

Women in Neurosurgery

131

Stuart Silverman, MS, MD, FAAN

Membership in Professional and Scientific Societies

Allegheny County Medical Society

American Academy of Neurology

American Society of Neuroimaging

Pennsylvania Medical Society

Pittsburgh Neuroscience Academy

Beth Snitz, PhD

Editorial Service

Editorial Board Member: Journal of the American Geriatrics Society (JAGS)

Ad hoc reviewer

Aging and Mental Health Journal of Alzheimer’s Disease

Alzheimer’s and Dementia Journal of Applied Gerontology

Biological Psychiatry Journal of Clinical and Experimental Neuropsychology

Gerontology Journal of the International Neuropsychological Society

Health Psychology Neuropsychology International Psychogeriatrics Personality and Neuroscience

JAMA Neurology Psychology and Neuroscience

Journal of the American Geriatric Society Schizophrenia Research Current Alzheimer Research

Grant Reviewer

Internal Reviewer, Department of Psychiatry Grant Review Committee, University of Pittsburgh

Membership in Professional and Scientific Societies

American Psychological Association

International Neuropsychological Society

Arthur Sonberg, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Association of Neuromuscular & Electrodiagnostic Medicine

Josif Stakic, MD

Editorial Service

Ad hoc reviewer

Headache journal

Membership in Professional and Scientific Societies

American Academy of Neurology

American Headache Society

Matthew Starr, MD

Editorial Service

Reviewer for abstracts for International Stroke Conference for 2016-17

132

Membership in Professional and Scientific Societies

American Academy of Neurology

American Heart Association

Ruth Anne Stetler, PhD

Editorial Service

Ad hoc reviewer

Brain Research Journal of Neurochemistry Brain Research Bulletin Journal of Neuroscience

CNS Neuroscience & Therapeutics Journal of Neuroscience Research

CNS & Neurological Disorders-Drug Targets Leukemia eNeuro Neurochemistry International

International Journal of Biological Sciences Recent Patents on CNS Drug Discovery Journal of Cerebral Blood Flow and Metabolism Translational Stroke Research

Leukotrienes & Essential Fatty Acids Prostaglandins

Membership in Professional and Scientific Societies

American Heart Association

International Society for Cerebral Blood Flow and Metabolism

Society for Neuroscience

Michelle Stevens, DO

Membership in Professional and Scientific Societies

American Association of Electrodiagnostic Medicine

American Board of Osteopathic Neurologissts and Psychologists

American Osteopathic Association

Dandan Sun, MD, PhD

Honors

Endowed Chair Professor in the Department of Neurology UPMC

Faculty Sponsor for Brackenridge Undergraduate Research Fellowship at University of Pittsburgh

Faculty Sponsor for American Heart Association Postdoc Fellowship Awardee Dr. Shanshan Song

Editorial Service

Editorial Board Member

Frontiers in Membrane Physiology

International Journal of Physiology, Pathophysiology and Pharmacology

Grant Review

Welcome Trust Research

Ad hoc reviewer – National Science Foundation grants

Journal of Cerebral Blood Flow and Metabolism Neurology

Journal of Neurochemistry Stroke

Journal of Neuroscience

Membership in Professional and Scientific Societies

American Physiological Society

Society for the Cerebral Blood Flow, Metabolism & Function

Society of the Chinese Bioscientists in America

Society for Neuroscience

133

Valerie Suski, DO

Honors

Pittsburgh Magazine Best Doctors List 2017

Membership in Professional and Scientific Societies

American Academy of Neurology

American Medical Association

American Osteopathic Association

Huntington’s Study Group

Movement Disorders Society

Parkinson’s Study Group

Alexandra Urban, MD

Honors

UPMC Neurology Residents Excellence in Didactic Teaching Award, 2017

Membership in Professional and Scientific Societies

American Academy of Neurology

American Epilepsy Society

Anne Van Cott, MD

Honor

2017 – Best Doctors (Neurology), Pittsburgh Magazine

Editorial Service

Ad hoc reviewer

Aging Health Journal of Neurology

Epilepsia Journal of Rehabilitation Research and Development

Epilepsy and Behavior Pharmacoepidemiology and Drug Safety

Epilepsy Research The American Journal of Geriatric Pharmacotherapy

Hospital Physician Epilepsy Board Review Manual

Research Centers for Disease Control and Prevention Special Emphasis Panel

Epilepsy Foundation of America’s Targeted Research Initiative for Seniors

VA Healthcare Network VISN 4 Competitive Pilot Project Fund (CPPF)

Membership in Professional and Scientific Societies

American Academy of Neurology

American Clinical Neurophysiology Society

American Epilepsy Society

Barbara Vogler, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Headache Society

134

Janet Waters, MD, MBA

American Academy of Neurology

Zongqi Xia, MD, PhD

Honors

September 2016 – Best poster award at the 32nd congress of the European Committee for Treatment

Research in Multiple Sclerosis (ECTRIMS) in London UK.

Editorial Board Member

Neuroimmunology and Neuroinflammation

Ad Hoc Reviewer

American Medicl Informatics Association Journal of Neurological Sciences

Annals of Neurolgy Multiple Sclerosis Journal

Arthritis Care and Research Neurology

Genes and Immunity

Membership in Professional and Scientific Societies

American Academy of Neurology

American Neruological Association

Janet Waters, MD

Editorial Service

Co-editor of textbook: Neurological Illness in Pregnancy: Principles and Practice

Membership in Professional and Scientific Societies

American Academy of Neurology

Lawrence Wechsler, MD

Editorial Service

Editor-in-Chief, Frontiers in TeleNeurology

Associate Editor, Translational Stroke Research

Editorial Board, Circulation Editorial Board, Stroke and Vascular Neurology

Ad hoc reviewer

Annals of Neurology New England Journal of Medicine

Neurology Stroke

Membership in Professional and Scientific Societies

American Academy of Neurology

American College of Physicians

American Medical Association

American Neurological Association

American Society of Neuroimaging

Society for Neuroscience

135

Claire Yanta, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Headache Society

Kejie Yin, MD, PhD

Honors

The Investigator Award, European Stroke Research Foundation

Editorial Service

Editorial Board Member

ARC Journal of Neuroscience (AJNS) Austin Neurology

Journal of Stroke Research

World Journal of Neuroscience

Ad Hoc Reviewer

Aging and Disease CNS Neuroscience & Therapeutics

Experimental Neurology

Metabolic Brain Disiease Nature Communications

Nature Methods Neurochemistry Internaitonal

Neuroscience Letters

PPAR Research Progress in Neurobiology

Translational Stroke Research

Membership in Professional and Scientific Societies

American Heart Association/American Stroke Association

International Society of Cerebral Blood Flow and Metabolism (ISCBFM)

Society for Neuroscience

Naoir Zaher, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

American Medical Association

American Clinical Neurophysiology Society

Islam Zaydan, MD

Membership in Professional and Scientific Societies

American Academy of Neurology

North American Neuro-Ophthalmologic Society

136

Feng Zhang, MD, PhD

Editorial Services

Editorial Board

NS & Neurological Disorders-Drug Targets (CNSND-DT) Austin Journal of Cerebrovascular Disease & Stroke

Grant Reviewer, National Science Foundation of China Ad hoc reviewer

Brain Research Molecular Neurobiology

Clinical Pharmacology & Biopharmaceutics Neurological Research CNS Neuroscience & Therapeutics Neuroscience

Journal of Visualized Experiments Pharmacology

Mini-review of Medical Chemistry Plos One Metabolic Brain Disease Translational Stroke Research

Molecular Biology Reports Scientific Reports Vascular Health and Risk Management

Membership in Professional and Scientific Societies

American Heart Association/American Stroke Association

International Society of Cerebral Blood Flow and Metabolism

Society for Neuroscience

Michael Zigmond, PhD

Editorial Service

Editor-in-Chief - Progress in Neurobiology

Ad hoc reviewer

The Open Ethics and Law Journal JUNE (Journal of Undergraduate Research Education) Neurology Research International Biology Image Library, Neuroscience Section

Neuroscience Bulletin Behavioral and Brain Functions

Engineering & Science Ethics

Membership in Professional and Scientific Societies

American Association for the Advancement of Science

American Society for Pharmacology and Experimental Therapeutics

International Brain Research Organization

New York Academy of Science

Sigma Xi

Society for Neuroscience

Saša Živković, MD, PhD

Editorial Service

Member, Editorial Advisory Board, World Journal of Hepatology

Grant Reviewer, Central Research Fund, University of Pittsburgh

Ad hoc reviewer

Acta Neurologica Scandinavica

Muscle Nerve Neurology

Transplantation Transplant International

137

Membership in Professional and Scientific Societies

ALS Research Group

American Academy of Neurology

American Association of Neuromuscular and Electrodiagnostic Medicine

Inflammatory Neuropathy Consortium (INC)

North East ALS Consortium (NEALS)

Peripheral Nerve Society

138

139

Members of the Faculty 2016-2017

Arun Antony, MD Assistant Professor

Anto Bagić, MD, PhD Associate Professor

Sarah Berman, MD, PhD Assistant Professor

Edward A. Burton, MD, DPhil, FRCP Associate Professor

Neil Busis, MD Clinical Professor

Guodong Cao, PhD Associate Professor

Jun Chen, MD Professor

Sherry Chou, MD, MSc, FNCS Visiting Associate Professor

Paula R. Clemens, MD Professor

James DiMatteis, MD

John J. Doyle, MD Associate Professor

Jan Drappatz, MD Associate Professor

Jeffrey Esper, DO Clinical Professor of Internal Medicine

Joanna Fong, MD Clinical Assistant Professor

Kathy Gardner, MD Assistant Professor

Gena Ghearing, MD Assistant Professor

Steven H. Graham, MD, PhD Professor

J. Timothy Greenamyre, MD, PhD Professor

Erica Grazioli, DO

Maxim Hammer, MD Associate Professor

Teresa G. Hastings, PhD Associate Professor

Rick Hendrickson, PhD Assistant Professor

Rock A. Heyman, MD Associate Professor

Eric Hoffman, PhD Research Assistant Professor

Houman Homayoun, MD Assistant Professor

Xiaoming Hu, MD Research Assistant Professor

Milos Ikonomovic, MD Associate Professor

Ashutosh Jadhav, MD Assistant Professor

Samay Jain, MD Assistant Professor

Ruchira Menka Jha, MD Clinical Instructor

Tudor Jovin, MD Associate Professor

Robert Kaniecki, MD Assistant Professor

Kelly Kay, DO Clinical Assistant Professor

Simin Khavandgar, MD Clinical Assistant Professor

Daniel Kinem, DO Neurohospitalist

Laurie Knepper, MD Associate Professor

David Lacomis, MD Professor

Erek Lam, MD Clinical Assistant Professors

Frank Lieberman, MD Professor

140

Guillermo Linares, MD Clinical Instructor

Hao Liu, PhD Research Assistant Professor

Oscar L. Lopez, MD Professor

Angela Lu, MD Clinical Assistant Professor

Lazarus Mayoglou, DO Clinical Assistant Professor

Edward Mistler, DO Clinical Assistant Professor

Bradley Molyneaux, MD, PhD Assistant Professor

Eric Ogren, MD Assistant Professor

Ojha, AJ, MD Clinical Assistant Professor

Jullie Pan, MD, PhD Professor

Vivek Reddy, MD Assistant Professor

Marcelo Rocha, MD Assistant Professor

Jingzi Shang, MD

Lori Shutter, MD Professor

Stuart Silverman, MD Clinical Associate Professor

Beth Snitz, PhD Assistant Professor

Josif Stakic, MD Assistant Professor

Matthew Starr, MD Assistant Professor

Ruth Ann Stetler, PhD Research Assistant Professor

Michelle Stevens, DO

Dandan Sun, MD, PhD Professor

Valerie Suski, DO Assistant Professor

Alexandra Urban, MD Assistant Professor

Anne Van Cott, MD Associate Professor

Amber Van Laar, MD Instructor

Barbara Vogler, MD Clinical Assistant Professor

Janet Waters, MD, MBA Clinical Assistant Professor

Lawrence Wechsler, MD Professor and Chair

Islam Zaydan, MD Assistant Professor

Michael Zigmond, PhD Professor

Saša Živković, MD Associate Professor

New Faculty Members

Faculty Member Previous Appointment

Brown, Merritt, MD University of PA Health System

Neurocritical Care Fellow

Erin Canale, MD Mount Carmel Mecial Group

General Neurologist

Cynthia Kenmuir, MD UPMC

Neuroendovascular Fellow

141

Karuna Mandava, MD Excela Health Systems

Private Neurology Practice

Robyn Massa, MD UPMC

Neurology Residency

Ajetesh Ojha, MD UPMC

Clinical Neurophysiology Fellow

Cosmin Sandulescu, MD Albert Einstein Medical Center

Neurology Residency

Arthur Sonberg, MD Carteret Medical Group

Neurologist

Ahmed Yassin, MD UPMC

Clinical Neurophysiology/EEG Fellow

Faculty Departures

Faculty Member New Position and Rank

Gena Ghearing University of Iowa. Iowa

Clinical Associate Professor

Vivek Reddy

Inter-Mountain Health Care, Salt Lake City, Utah

Chief Health Information Office

Puja Aggarwal Private Practice

Clinical Education 2016-2017

House Officers

PGY 4 Co-Chief Residents Medical Education

Brian Hanrahan, MD State University of New York Upstate Medical University

Eric Jackowiak, MD Indiana University School of Medicine

Jodi Manners, MD University of Pittsburgh School of Medicine

PGY 4 Residents

Kiruba Dharaneeswaran, MD Pennsylvania State University College of Medicine

Natalia Gonzales, MD Pennsylvania State University College of Medicine

James Lee, MD, PhD University of Illinois College of Medicine

Deepak Soneji, MD University of Pittsburgh School of Medicine

PGY 3 Residents

Kevin Elmore, MD University of Illinois College of Medicine

142

Michael Isfort, MD

Ohio State University College of Medicine

Christina Kyrtsos, MD Penn State University College of Medicine

Pouria Moshayedi, MD, PhD Tehran University of Medical Sciences

Sherya Nayak, MD Ohio State University College of Medicine

Madison Pilato, MD University of Rochester School of Medicine & Dentistry

Ying Sun, MD Chicago Medical School at Rosalind Franklin University of Medicine

& Science

PGY 2 Residents

Yasmin Aziz, MD Drexel University College of Medicine

Adam Barron, MD Medical College of Wisconsin

Lauren Brandes, MD Emory University School of Medicine

Devin Burke, MD State University of NY Upstate Medical University

Steven Gangloff, MD State University of New York At Buffalo of Medicine

Michael Korsmo, MD Tulane University School of Medicine

Xiaowei (Bill) Su, MD, PhD Pennsylvania State University College of Medicine

PGY 1 Residents

Paige Banyas Lake Erie College of Osteopathic Medicine, Erie

Preeya Fozdar University of Virginia School of Medicine

William Jarrard Medcial College of Georgia School of Medicine

Ruhul Rao Tulane University School of Medicine

Alexandria Sadasivan Albany Medical College of Union Univeristy

Corinne Smith Lake Erie College of Osteopathic Medicine, Erie

Carlos Villamizer-Roales University of Texas Medical School at Houston

Neurology Fellows Medical School Attended Residency Training

Bradley Klein, MD State University of NY Upstate

Medcial University

New York Presbyterian-

Columbia University Medical

Center Neurology

Pratit Patel, M.B., BS Ssurat Municipal Institute of

Medical Education

Univrsity of Minnesota Medical

Center Neurology

Habibullah Ziayee, MD St. George’s University, School

of Medicine

Jackson Memorial Hospital

Neurology

Muhammad Bilal, M.B., B.S. Quaid-E-Azam Medical

College, Islamia University

University of Louisville

Neurology

Minji Kim, MD Yeungnam University – South

Korea

New York Presbyterian-

Columbia University Medical

Center Neurology

Adam Kney, MD

University of Illinois College of

Medicine

University of Pittsburgh Medical

Center Child Neurology

143

Mahmoud Salhab, MB., B.S.

Jordan University of Science

and Technology, Faculty of

Medicine

University of New Mexico

Neurology

Stephanie Paolini, MD University of South Carolina

School of Medicine

University of Pittsburgh Medical

Center Neurology

Robyn Massa, MD University of Maryland School

of Medicine

University of Pittsburgh Medical

Center Neurology

Jason Massa, MD

Andrew Levin, MD Ohio State University College

of Medicine

University of Pittsburgh Medical

Center Neurology

Megan Mantica, MD State University of NY Upstate

Medical University

University of Pittsburgh Medical

Center Neurology

Cynthia Kenmuir, MD University of Toledo College of

Medicine

University of Pittsburgh Medical

Center Neurology

Gregory Walker, MD University of British Columbia,

Faculty of Medicine

Uniersity of British Columbia

Neurology

Departing House Officers

Residents New Position

Alexandra Czap, MD

Neuro-Oncology Fellowship

Massachusetts General Hospital and Dana-Farber

Cancer Institute/Bridham and Women’s Hospital

Stella Lai, MD

Clinical Neruophysiology Fellowship

University of Chicago

Andrew Levin, MD

Headache Fellowship

Department of Neurology UPMC

Megan Mantica, MD Neuro-Oncology Fellowship

Department of Neurology UPMC

Jennifer Nichols, MD

Movement Fellow

Oregon Health & Science University

Stephanie Paolini, MD

Clinical Neurophysiology Fellow

Department of Neurology UPMC

Fellows New Position Location

Kaustubh Limaye, MD Neurology Faculty

University of Iowa Health Care

Gregory Walker, MD

Neruoendovascular Fellow

Clinical Instructor

Department of Neurology

UPMC

144

Prasanna Tadi, MD

Assistant Professor Department of Neurology Creighton

University CHI Health, Omaha,

Nebraska

Levi Shelton Assistant Professor Department of Pediatrics, Division of

Child Neurology

Neil Munjal Critical Medicine Fellowship

Children’s Hospital of Pittsburgh

UPMC

Jenna Gaesser Assistant Professor Department of Pediatrics, Division of

Child Neurology

Adam Kney Clinical Neurophysiology

Fellowship

Department of Neurology

UPMC

Diana Mnatsakanova, MD NeuroMuscular Fellow University of Iowa Health Care

Katherine Anetakis, MD Assistant Professor in

Neurological Surgery

Center for Clinical Neurophysiology

UPMC

Cosmin Sandulescu, MD Neurology Faculty Attending Geisinger Healthcare System

Fellowship Directors

Alexandra Urban, MD Epilepsy Fellowship Program

Robert Kaniecki, MD Headache Fellowship Program

Ashutosh Jadhav, MD Vascular Neurology Fellowship Program

Brian Jankowitz, MD EndoVascular Fellowship

Timothy Greenamyre, MD Movement Disorders Fellowship Program

Alexandra Urban, MD Clinical Neurophysiology

Jan Drappatz, MD Neuro-Oncology Fellowship

Neurology Mentors

Jun Chen, MD Lili Zhang

Yun Wu

Zhongfeng Weng

David Lacomis, MD David Avila

145

Faculty Teaching and Mentoring Contributions

Junior Faculty Research Mentoring

Jun Chen, MD

Feng Zhang, MD, PhD

Research Assistant Professor

Studies cellular & molecular mechanisms of ischemic neuronal injury

using rodent models of brain ischemia. Supported by AHA SDG award.

Xiaoming Hu, MD

Research Assistant Professor

Studies mechanisms of neuron-glia interactions under conditions of

ischemic injury or Parkinson’s disease.

Ruth Anne Stetler, PhD

Research Assistant Professor

Investigating the molecular mechanism underlying ischemic brain injury

and neuronal cell death.

Kiang Fong Liou, PhD

Research Assistant Professor

Study molecular and cell biology methods to identify key proteins that

participated in the cell death process in response to toxins.

Paula Clemens, MD

Hongshuai Li, MD, PhD

Assistant Professor of Orthopedic Surgery, University of Pittsburgh

Michele Yang, MD

Clinical Instructor, Pediatric Neurology, Denver Children’s Hospital,

Denver, CO

Roxanna Bendixen, PhD

Assistant Professor of Occupational Therapy, University of Pittsburgh

Amber van Laar, MD, PhD

Instructor, Neurology, University of Pittsburgh

Araya Puwanant, MD

Assistant Professor of Neurology, University of Pittsburgh

David Lacomis, MD

Udai Pandy, PhD Dept. of Pediatrics and Neurobiology, CHP: molecular mechanisms of ALS

Post-Doctoral Research Mentoring

Arun Antony, MD

Brian Hanrahan, MD Neurology, Resident University of Pittsburgh School of Medicine

Anto Bagic, MD, PhD

Stephanie Paolini, MD

Neurology Resident EEG Project mentor with Dr. Baldwin

Megan Mantica, MD

Neurology Resident EEG Project mentor with Dr. Baldwin

146

Sergiu Abramovici, MD

PGY5 Epilepsy Fellow ICM Project, Epidemiology Chapter, SPECT project

Palak Shah, MD

PGY6 Epilepsy Fellow SPECT Project

Jenna Robinson

UPitt Neurosci Prog Student EMU Care Project

Sarah Berman, MD, PhD

Victor Van Laar, PhD The role of parkin in neuronal mitochondrial dynamics

April Dukes, PhD Neuroprotection by selenoproteins against toxin-induced cell death

Edward Burton, MD, DPhil

April Dukes, PhD Neuroprotection by selenoproteins against toxin-induced cell death

Victor Van Laar, PhD Mitochondrial dynamics in neurodegeneration

Guodong Cao, PhD

Qinghai Xia Visiting Scholar, Department of Neurology, University of Pittsburgh

Xinzhi Chen, MD, PhD Research Associate, Department of Neurology, University of Pittsburgh

Fenghua Chen Research Associate, Department of Neurology, University of Pittsburgh

Lihong Hang Visiting Scholar, Department of Neurology, University of Pittsburgh

Jun Chen, MD

Guohua Wang Postdoctoral Fellow, University of Pittsburgh

Jinchao Xia Postdoctoral Fellow, University of Pittsburgh

Shangfeng Zhao Postdoctoral Fellow, University of Pittsburgh

Ziangrong Liu Postdoctoral Fellow, University of Pittsburgh

Kathy Gardner, MD

Emin Fedan, MD Postdoctoral Fellow, University of Pittsburgh

Cheran Erlangovan, MD Postdoctoral Fellow, University of Pittsburgh

Monica Vulchi, MD Postdoctoral Fellow, University of Pittsburgh

Navya Dasyam, MD Postdoctoral Fellow, University of Pittsburgh

Steven Graham, MD, PhD

Robert Hickey, MD Pediatrics mentor

147

J. Timothy Greenamyre, MD, PhD

Briana De Miranda, PhD Postdoctoral Fellow

Emily Rocha, PhD Postdoctoral fellow

Chris Bodle, PhD Postdoctoral fellow

Teresa Hastings, PhD

Caitlyn Barrett, PhD Role of mitochondrial GPx4 in neuroprotection

Julie M. Breckenridge, PhD Neuroprotection by selenoproteins against toxin-induced cell death

Xiaoming Hu, MD

Jing Xu, PhD Post-Doctoral Fellow, Visisting Scholar, University of Pittsburgh

Wen Zhu, MD Post-Doctoral Fellow, Research Associate, University of Pittsburgh

Yanling Wang, MD Post-Doctoral Fellow, Associate Professor, Luhe hospital, China

Milos Ikonomovic, MD

Zhiping Mi, PhD

Postdoctoral fellow

Oxidized Phospholipids and Synaptic changes in Mild Cognitive

Impairment

Brista Iordanova, PhD

Postdoctoral Research Fellowship Training in the Neurobiology of

Neurological Disease “Effects of cerebral amyloid angiopathy on blood

flow and oxygen metabolism?

Samay Jain, MD, MSc

Amber Van Laar, MD Movement Disorders Fellowship

Jen Han, MD Movement Disorders Fellowship

Lauren Nathbony, MD Resident Mentor

Cosmin Sandulescu, MD Movement Disorders Fellowship

Robyn Massa, MD Movement Disorders Fellowship

Tudor Jovin, MD

Ridwan Lin, MD

Interventional Neuroradiology Fellowship, Riverside Medical Center,

Columbus, OH

Dean Kostov, MD Interventional Neuroradiology Fellowship

Hilal Kanaan, MD Interventional Neuroradiology Fellowship

Mouhammad Jumaa, MD Interventional Neuroradiology Fellowship

Syed Zaidi, MD Interventional Neuroradiology Fellowship

David Panczykowsky, MD Interventional Neuroradiology Fellowship

148

Grefory Weimer, MD Interventional Neuroradiology Fellowship

Cynthia Kenmuir, MD Interventional Neuroradiology Fellowship

Laurie Knepper, MD

Steve Gangloff Neurology Resident PGY-1

David Lacomis, MD

Deepak Soneji Neurology Resident PGY-1

Bradley Molyneaux, MD, PhD

Hazem Shoirah University of Pittsburgh Stroke Fellow

Jullie Pan, MD, PhD -

Palak Shah, MD Epilepsy Fellowship research program

Vincent Carson, MD “Quantitative EEG, resting connectivity and AED withdrawal,”

Department of Pediatric Neurology

Lori Shutter, MD

Ruchira Jha, MD Junior Neurocritical Care Faculty

Susanne Muehlschlegel, MD Assoc Professor of Neurology UPMC

Jonathan Elmer, MD Asst Prof Dept of Emergency Medicine and Critical Care UPMC

Josh Keegan, MD Neurocritical Care Medicine Fellow

Namir Khandker, MD Neurocritical Care Medicine Fellow

Dandan Sun, MD, PhD

Nabiul Hasan

Postdoctoral fellow Study of C1 transporters in ischemic brain injury

Susan Song

Postdoctoral fellow Study of C1 transporters in ischemic brain injury

Karen Carney

Postdoctoral fellow Study of DHA-mediated neuroprotection after traumatic brain injury

Iqbal Bhuiyan

Postdoctoral Fellow Study of intracellular Ca2+ rise in microglial migration

Gulnaz Begum

Postdoctoral Fellow Study of chloride transporter in GBM tumor cells

Alexandra Urban, MD

Ahmed Yassin, MD

PGY6 Epilepsy Fellow QI Project: The effect of automatic SPECT njectors (ASI) on the safety and

yield of obtained SPECT studies

149

Brian Hanrahan, MD

Neurology Chief Resident QI Project: Improving the process and efficiency of stat EEG

Anne Van Cott, MD

Kara Wyant, MD University of Pittsburgh Neurology Resident

Alexis Steinberg, MD University of Pittsburgh Neurology Resident

Christina Catherine, MD, PhD University of Pittsburgh Neurology Resident

Janet Waters, MD

Stella Lai University of Pittsburgh Neurology Resident

Kejie Yin, MD, PhD

Xuejing Zhang Postdoctoral Fellow, Neurology Department UPMC

Ping Sun Postdoctoral Fellow, Neurology Department UPMC

Xinxin Yang Postdoctoral Fellow, Neurology Department UPMC

Feng Zhang, MD, PhD

Zhongfang Weng Postdoctoral Student, University of Pittsburgh

Lili Zhang Postdoctoral Student, University of Pittsburgh

Yang Sun Postdoctoral Student, University of Pittsburgh

Tuo Yang Postdoctoral Student, University of Pittsburgh

Graduate Student Mentoring and Advising

Timothy Greenamyre, MD, PhD

Meghan Bucher, PhD Candidate, CNUP, University of Pittsburgh (JTG, Chair)

Xiaoming Hu, MD

Wei Cai, MD, PhD Sun Yat-Sen Universit exchange student, University of Pittsburgh

Yuguo Xia, MD Research Associate, University of Pittsburgh

Jianyi Wang, MD Xiangya School of Medicine exchange student, University of Pittsburg

Huan Lie, MD Xiangya School of Medicine exchange student, University of Pittsburg

Xuejiao Dai, MD Xiangya School of Medicine exchange student, University of Pittsburg

150

Oscar Lopez, MD

Alexis Steinber, MD

Project: Sensitivity, specificity and reliability of three pathological criteria

for Alzheimer’s disease

Neelesh Nadkarni K-23 K- Awards mentor

Marcelo Rocha, MD, PhD

Shashvat Desai, MD

Research Post-doctoal Fellow, Research Project: Clinical Characterizaton of

fast and slow progressors of LVO using observational retrospective studies

Lori Shutter, MD

Yumna Saeed, MD Neurocritical Care Interest

Beth Snitz, PhD

Sarah Goldberg Clinical Supervisor – Psychology

Ryan Malave Master’s student – Epidemiology, Thesis project co-advisor

Dandan Sun, MD, PhD

Yang Chung

PhD candidate – Thesis committee member of CNUP, University of

Pittsburgh

Xiudong Guan, MD PhD Student – Tiantan Medical Hospital, China

Hanshu Zhao, Graduate

Student Study of roles of Na+/H+ exchanger in microglial activation after ischemia

Ann Van Cott, MD, FAAN

Megan Miller Univerity of Pittsburgh PhD candidate

Kejie Yin, MD, PhD

Xuelian Tang University of Pittsburgh, Department of Neurology, UPMC

Feng Zhang, MD, PhD

Meijuan Zhang Pre-doctoral students: University of Pittsburgh

Leilei Mao Pre-doctoral students: University of Pittsburgh

Yang Sun Pre-doctoral students: University of Pittsburgh

Jessica Zhang Pre-doctoral students: University of Pittsburgh

Peiying Li Pre-doctoral students: University of Pittsburgh

Haiyue Zhang Pre-doctoral students: University of Pittsburgh

Undergraduate Mentoring and Advising

Anto Bagic, MD, MSc, PhD

Julia Zheng

University of Pittsburgh Neuroscience Program Student EEG-MEG Project

2013-Present

151

Sarah Berman, MD, PhD

Swati Rajprohat June 2013 - Present

Teresa Hastings, PhD

Meghan Bucher Research project: Role of selenoproteins in models of Parkinson’s disease

Shruthi Shankar

Research project: Role and interacting partners of neuronal Na+K+ATPase,

alpha 3

Milos Ikonomovic, MD

Andrew Morrison 2013 - 2016 – University of Pittsburgh, Thesis Research and Writing

Ye Weon Ryu 2013 – Present – University of Pittsburgh, Thesis Writing

Alisha Ambe 2016 - Present – University of Pittsburgh, Independent Research

Grazia Candiotti 2014 - 2016 – University of Pittsburgh, Thesis Research and Writing

Beth Snitz, PhD

Jessica Kerstetter Spring 2016 – Research Advisor – First Experience in Research

Taylor Urban Spring 2016 – Research Advisor – First Experience in Research

Dandan Sun, MD, PhD

Abhishek Mishra Study DHA-mediated neuroprotection after traumatic brain injury

Rachana Nayak Study DHA-mediated neuroprotection after traumatic brain injury

Alexandra Urban, MD

Jenna Robinson Undergraduate Neuroscience – Project QI: Subtle MRI lesions in patients with

intractable epilepsy and normal MRIs

Medical Student Mentoring

Sarah Berman, MD, PhD

Megan Bucher Comprehensive Exam Committee, Center for Neuroscience at UPMC

Anthony Otero

Comprehensive Exam and Doctoral Dissertation Committee,

Interdisciplinary Biomedical Graduate Program

Darius Becker Krail Comprehensive Exam Committee, Center for Neuroscience at UPMC

Briana De Miranda, PhD

Advisory Committee Member, NINDS Postdoctoral fellowship: Training in

the Neurobiology of Disease - UPMS

152

Edward Burton, MD, DPhil

Jacob Kantorotwitz Pitt MD student scholarly project mentor 2016 - present

Neil Sharma Pitt MD student scholarly project mentor 2016 - present

Phil Bartel Pitt MD student scholarly project mentor 2016 - present

Wenting Xie Tsinghua Scholar mentor 2015- present

Enhua Shao Tsinghua scholar mentorship 2015- present

Jan Drappatz, MD

Daniel Lesky Medical Student precepting - Neoplasia

Myung Sun Choi Medical Student precepting - Neoplasia

Allana White Medical Student precepting - Neoplasia

Daniel Suter Medical Student precepting - Neoplasia

Bhavana Chapman Medical Student precepting - Neoplasia

Samay Jain, MD, MSc

Julie Garringer MS II

Seth Hepner MS III/IV

David Lacomic, MD

Deepak Soneji Mentor – for PGY-4 resident

Bill Su Mentor – for PGY-1 resident

Oscar Lopez, MD

Sarah Yousef Medical Student

Marcelo Rocha, MD, PhD

Devin Burke, MD

Neurology Resident – Project: Predicting hemorrhagic conversion of

ischemic strokes after initiation of anticoagulation of secondary stroke

prevention

Lori Shuter, MD

Kiruba Dharaneeswaran, MD Neurology Resident (Neurocritical Care interest) UPMC

Alexis Steinberg, MD Neurology Resident (Neurocritical Care interest) UPMC

Christian Ricks, MD Neurology Resident (Neurocritical Care interest) UPMC

153

Beth Snitz, PhD

Yujing Zhao Medical Student – Scholarly Project mentor

Valerie Suski, MD

Michelle Daile Medical Student – University of Pittsburgh School of Medicine 2016-2017

Zongqi Xia, MD, PhD

Michael Isofort, MD Resident Research Project: health care utilization pattern in MS patients

receiving disease-modifying treatments.

Shreya Nayak, MD Supervised completing a review article: emerging biosensor monitor in

chronic neuroinflammaton and neurodegeneration

Faculty Participation in Graduate Level Teaching, Mentorships, and Service

Jun Chen, MD Lecture

Apoptosis-Cellular and Molecular

Neurobiology MSNBIO

J. Timothy Greenamyre, PhD Lecture Bioenergetics and Excitotoxicity

Lecture Mitochondrial Disorders

Lecture Parkinson’s disease

Teresa Hastings, PhD 7 Lectures Cellular and Molecular Neurobiology

Lecture Neuropharmacology

Course Director

John Doyle, MD Co-Director of Neuroscience Course PMS1

Co-Director of Neurology CME Course, Neurology in the Medicial Office

Jeffrey Esper, DO, MS Clinical Course Director – Neurosensory System at LECOM

Teresa Hastings, PhD Director, Honors College Health Sciences Undergraduate Summer Research

Fellowship Program

Cellular and Molecular Neurobiology

Milos Ikonomovic, MD MSNBIO – Topics in Neurological Disorders

Laurie Knepper, MD Clinical Neuroscience Clerkship (Co-Director)

The Neurological Examination

Janet Waters, MD Co-Director of CME course: Obstetrical Neurology Conference

Claire Yanta, MD Advanced Physical Examination, Neurology Section

Assistant Clerkship Director

154

Additional Graduate Student Mentoring and Advising

Sarah Berman, MD, PhD

PSTP Career Advisor 2013–

Present Kassandra O’Brien

PSTP Career Advisor 2014–

Present Wai Lok (Cyrus) Tsang

152

PSTP Career Advisor 2015–

Present Andrew Lamade

MSTP Career Advisor 2017-

present Jenna Gale

MSTP Career Advisor 2017-

present Rahilla Tarfa

J. Timothy Greenamyre, MD, PhD MSTP Career Advisor Gil Hoftman

MSTP Career Advisor Michelle Dail

MSTP Career Advisor Eric Strobl

Teresa Hastings, PhD CNUP Graduate Advisor

Committee Zhenyu Liu

CNUP Graduate Advisor

Committee Louisa Ho

CNUP Graduate Advisor

Committee Leslie Colgan

CNUP Graduate Advisor

Committee Victor Van Laar

CNUP Graduate Advisor

Committee Nicole Larsen

Beth Snitz, PhD PhD Committee Meghan Mattos

PhD Committee Samantha Rosenthal

Committee Memberships

Sarah Berman, MD, PhD Member, PSTP Admissions Committee

Member, PSTP Steering Committee

Member, MSTP Admissions Committee

Member. MSTP Admissions/Recruiting

Committee

Member, MSTP Advisory Committee

Edward Burton, MD, DPhil Member, FAST Advisory Committee

155

Teresa Hastings, PhD Member, MSTP/CNUP Admissions Committee

Member, MSTP Steering Committee

Dandan Sun, PhD Member, CNUP Evaluation Committee

Member, CNUP Recruitment

Thesis and Dissertation Committee Service

Sarah Berman, MD, PhD Member, Doctoral

Dissertation Committee Anthony Otero

153

Teresa Hastings, PhD Chair –CNUP Dissertation

Committee Mahlon Collins

Member – CNUP Dissertation

Committee Hyunjung Oh

Member –CNUP Dissertation

Committee Eser Yilmaz

Faculty Participation in Medical School Teaching, Mentorships, and Service

Teaching

Arun Antony, MD

Clinical Conference 1: Localizing sensory and motor

Dysfunction MS1: Neuroscience

5 Lectures: Seizures and Epilepsy MS1: Neuroscience

Anto Bagic, MD, PhD

Lecture: Intro to pathophysiology of epileptic seizures MS1: Neuroscience

Clinical Pharmacology MS4: Clinical Pharmacology

Lecture: Brief Overview of seizures and epilepsy MS1: Neuroscience

Lecture: Intro to Treatments of Seizures and Epilepsy MS1: Neuroscience

Sarah Berman, MD

Lecture: Tremor and Dystonia MS1: Neuroscience

Edward Burton, MD, DPhil

Myoclonus, tics, and other movement disorders (NO

PODCAST) MS1: Neuroscience

Ataxia (NO PODCAST) MS1: Neuroscience

156

Neil Busis, MD

Clinical Conference 3: Syndromes Involving Brainstem and

Cranial Nerves MS1: Neuroscience

Clinical Conference 2: Motor Systems MS1: Neuroscience

Clinical Conference 4: Localizing sensory and motor

dysfunction MS1: Neuroscience

Guodong Cao

Lecture: Neuropharmacology MS4: ILS Clinical Pharmacology

Paula Clemens, MD

2 -PBL Introduction: “Trouble Walking” MS1: Cellular & Path Basis of Disease

John Doyle, MD

Introduction to the Course MS1: Neuroscience

Lab1: CNS Anatomy: Forebrain MS1: Neuroscience

Neuroanatomy Workshop 1: Coronal and horizontal brain

sections MS1: Neuroscience

Lecture: Localization and Clinical Neurology MS1: Neuroscience

Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience

Clinical Conference 2: Syndromes Involving Brainstems and

Cranial Nerves MS1: Neuroscience

Lectures: Radiology Review MS1: Neuroscience

Lecture: Ataxia MS1: Neuroscience

Lecture: Clinical Phenomenology of Movement MS1: Neuroscience

Clinical Conference 3: Motor Systems MS1: Neuroscience

Case: Integrative review case 1: Autonomic Nervous

System Disorders MS1: Neuroscience

Case: Integrative review case 2: Drugs and Nerve Cell

Function MS1: Neuroscience

Lecture: Attentional Systems & Disorders of Consciousness

(Coma) MS1: Neuroscience

Lecture: Language and Communication MS1: Neuroscience

Jan Drappatz, MD

Lectures: Neuro-Oncologic Emergencies MS4: ILS Neoplasia & Neoplastic Diseases

Erica Grazioli, DO

Lecture: Multiple Sclerosis MS1: Neuroscience

J. Timothy Greenamyre, MD, PhD

Lecture: Parkinson’s Disease, Neurobiology of Disease MS1: Neuroscience

Lecture: Mitrochondrial Disorders, Basic Mechanisms of

Neurological Disease MS1: Neuroscience

Lecture: Bioenergetics and Excitotoxicity, Basic

Mechanism of Neurological Disease MS1: Neuroscience

157

Theresa Hastings, PhD

Lecture: Parkinson’s Disease “Neuropharmacology” MSNBIO 2614 / MSMPL 3375

Rock Heyman, MD

Lectures: Multiple Sclerosis MS1: Neuroscience

Lecture: Problem Based Learning MS1: Neuroscience

Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience

Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience

Clinical Conference 3: Syndromes involving brainstem and

cranial nerves MS1: Neuroscience

Clinical conference 4: Localizing sensory and motor

dysfuntion MS1: Neuroscience

Lectures: Physical Therapy Master: Neuroscience

Lectures: Occupational Therapy Masters: Neuroscience

Houman Homayoun, MD

Lecture: Presentation – NO PODCAST MS1: Neuroscience

3 - Lecture: Movement Disorders MS1: Neuroscience

Lecture: Parkinsonian States MS1: Neuroscience

Ashu Jadhav, MD, PhD

6 Lectures: Stroke MS1: Neuroscience

Tudor Jovin, MD

Lecture: Interventional Neuroradiology MS1: Neuroscience

Robert Kaniecki, MD

6 -Lectures: Headache Assessment and Management MS3: Neurology Clerkship

Clinical Confernce 2: Motor Systems Degeneration MS1: Neuroscience

Lecture: Pharmacology of Pain Management MS4: Clinical Pharmacology

Simin Khavandgar, MD

Clinical Conference 3: Sydromes involving brainstem and

cranial nerves Clinical Conference 3

Clinical Conference 1: Localization of Dysfuntion

Clinical conference 1

Laurie Knepper, MD

12 – Small Groups: Neurological Exam MS1: Intro to Physical Exam

4-ICS Course MS1: Neuroscience

12-Small Groups: NBME Neuro Shelf Review Clerkship MS3: Neurology Clerkship

Clinical Conference l: Localization of Dysfunction MS1: Neuroscience

Clinical Conference 1: Localizing sensory and memory

dysfuntion MS1: Neuroscience

Small Groups: The Neurological Exam-Advance Physical Exam MS3: Neuroscience

158

David Lacomis, MD

Lecture: Critical Illness Neruomuscular Disease MS1: Neuroscience

Lecture: Motor Neuron Disease MS4: Elective Phys Med & Rehab

Lecture: Peripheral Nerve & Anterior Horn Disorders MS1: Neuroscience

Erek Lam, MD

Lecture: Sleep Wake Disorders MS1: Neuroscience

Lecture: Neurobiology of Circadian Rhythms MS1: Neuroscience

Frank Lieberman, MD

Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience

Clinical Conference 4: Localizing sensory and motor

dysfunction MS1: Neuroscience

Oscar Lopez, MD

Small Group: Workshop WS5- Case Studies in Injury and

Repair MS1: Cellular & Path Basis of Disease

Small Group: Workshop WS7 – Case Studies in Neoplasia MS1: Cellular & Path Basis of Disease

Small Group: Workshop WS6 – Virtual Slides: Colon

Adenocarcinoma and Melanoma MS1: Cellular & Path Basis of Disease

Angela Lu, MD

Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience

12 Lectures: Peripheral Neuropathy MS3: Clinical Neuroscience

Bradley Molyneaux, MD

Lecture: Science of Resuscitation MS4: EMED Course

Small Group: Syndromes Involving the Brainstem and

Cranial Nerves, Clinical Conference 2 MS1: Neuroscience

Ajitesh Ojha, MD

Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience

Clinical Conference 3: Syndromes involving brainstem and

cranial nerves MS1: Neuroscience

Clinical Conference 4: Localizing sensory and motor

dysfunction MS1: Neuroscience

Small Group: APE MS1: Neuroscience

Araya Puwanant, MD

2- Small Group: PBL Introduction: “Trouble Walking” MS1: Cellular & Path Basis of Disease

Lecture: Skeletal Muscle I MS1: Cellular & Path Basis of Disease

Lecture: Skeletal Muscle II MS1: Cellular & Path Basis of Disease

159

Vivek Reddy, MD

Clinical Conference: Traumatic Brain Injury MS1: Neuroscience

Lori Shutter, MD, FCCM, FNCS

Clinical Conference 2: Syndromes Involving the

Brainstem and Cranial Nerves MS1: Neuroscience

157

Clinical Conference 4: Localizing Sensory and Motor

Dysfunction MS1: Neuroscience

Lecture: Surgery Internship Preparation Course

“Pronouncing Patient Death” MS4: Neuroscience

2 - Lectures: Introduction to Medical Decision Making MS1: Neuroscience

Beth Snitz, PhD

Lecture: Multimodal methodologies to assess CNS

disorders in epiedemiologic studies MS1: Neuroscience

Lecture: Dementia/Major Neurocognitive Disorders MS1: Neuroscience

Lecture: Principals of Neuroepidemiology MS1: Neuroscience

Josef Stakic, MD

Clinical Conference 1: Localization of dysfunction MS1: Neuroscience

Clinical Conference 3: Syndromes involving brainstem and

cranial nerves MS1: Neuroscience

Clinical Conference 4: Localizing sensory and motor

dysfunction MS1: Neuroscience

Lecture: Dementia and Delirium MS1: Neuroscience

6 - Lecture: Headache MS3: Neurology Clerkship

Valerie Suski, DO

Clinical Conference 3: Syndromes involving brainstem and

cranial nerves MS1: Neuroscience

Small Group: APE Session, Neuro examination MS2: Advanced Physical Exam 2

Alexandra Urban, MD

Lecture: Management of Epilepsy-Epilepsy vignettes,

Clinical Pharmacology MS4: ILS Clinical Pharmacology

Clinical Conference 4: Localizing Sensory and Motor

Dysfunction MS1: Neuroscience

Small Group: APE Neurology Advance Physical Exam MS12: Advanced Physical Exam 1

3- Lectures: Diagnosis and Management of Seizures MS3: Clinical Neuroscience Clerkship

Anne Van Cott, MD

PBL Sessions: Case 7, 8 and 9 MS2- Integrated Case Studies

160

Amber Van Laar

Lecture: Tremor and Dystonia MS1: Neuroscience

3 Lectures: Movement Disorders Overview MS1: Neuroscience

Janet Waters, MD

Lecture: Neurology in Pregnancy MS1: Clinical Neuroscience

Lawrence Wechsler, MD

Clinical Conference 4: Localization Sensory and Motor

Dysfunction MS1: Neuroscience

Claire Yanta, MD

Lecture: Neurocognitive Foundations of Executive

Function/Frontotemporal Dementia MS1: Neuroscience

Lecture: Neurological Examination MS1: Advance Physical Exam 1

3 - Small Groups: The Neurological Exam-Advance

Physical Exam MS1: Advance Physical Exam 1

Islam Zaydan, MD

Lecture: Alzheimer’s and Lewy body dementia MS1: Neuroscience

5 - Lectures: Multiple Sclerosis & CNS demyelinating

diseases MS1: Neuroscience

Lecture: Dementia MS1: Neuroscience

Sasa Zivkovic, MD

Clinical Conference 2: Syndromes involving Brainstem and

Crainial Nerves and Motor Degeneration MS1: Neuroscience

Clinical Neuroscience Clerkship MS3: Clerkship

Lecture: Neurobiology of Disease MSN2112 / NROSCI2112

Medical Student Mentoring

Sarah Berman, MD Mentored Scholarly

Project Roy Nikita

Paula Clemens, MD Mentored Scholarly

Project Corey Toocheck

Samay Jain, MD Mentored Scholarly

Project Christian Agudelo

161

162

Department of Neurology Grand Rounds 2016-2017

Sept 7, 2016 VISITING

Allison Brasher, MD Title: “Disease of ATP1A3: Learning from our Patients”

1105AB 4-6PM

Sept 14, 2016 Residents CPC Series James Lee, MD Title: “A Diagnosis Frequently Made at Autopsy” Mentor: Jan Drappatz, MD

1105AB 4-6PM

Sept 21, 2016 In-House

Sasa Zivkovic, MD Title: “Guillain Barre Syndrome 1916-2016: First Hundred Years”

1105AB 4-6PM

Sept 28, 2016 In-House

Marcelo Rocha, MD Title: “Pathophysiology of Acute Intracranial Large Vessel Occlusion: Emerging Trends”

1105AB 4-6PM

SECOND QUARTER – OCT-DEC 2016

Oct 5, 2016 Residents CPC Series Eric Jackowiak, MD Title: "Parkinson's, Psychosis, and Pimavanserin" Mentor: Dr. Van Laar

1105AB 4-6PM

Oct 12, 2016 No Grand Rounds – Holiday Break Yom Kippur

Oct 19, 2016 UPMC S701 Scaife Hall

200 Lothrop Street Pittsburgh, PA 15213

Office 412-624-9415

Direct line 412-624-0764

FAX 412-624-5610 wileyca@upmc.edu

Clayton A. Wiley, MD/PhD

Professor of Pathology

Director of Neuropathology

PERF Endowed Chair UPMC Presbyterian Hospital Division of Neuropathology Title: Human Zika and WNV infections: What is the difference? Encephalitis or Encephalopathy?

1105AB 4-6PM

Oct 26, 2016 Residents CPC Series Natalia Gonzales, MD Title: “A Commonly Misdiagnosed Cause of Polyneuropathy: TTR Familial Amyloidosis” Mentor: Sasa Zivkovic, MD

1105AB 4-6PM

Nov 2, 2016 VISITING Dr. Bagic requested

Lawrence Hirsch, MD Yale University School of Medicine Title: “Critical Care EEG Monitoring: Past, Present and Future”

1105AB 4-6PM

Nov 9, 2016

Residents CPC Series Jennifer Nichols, MD Title: "Movement Disorder Emergencies"

Mentor: Houman Homayoun, MD

1105AB 4-6PM

163

Nov 16, 2016 JOINT - Neurosurg

Joint GR – Neurosurgery/Neurology David O. Okonkwo, MD, PhD Prof. & Executive Vice Chair, Clinical Operations Clinical Director, Brain Trauma Research Center Dept. of Neurologic Surgery Title: “Biomarkers and Neuroimaging of Chronic Traumatic Encephalopathy” Julia Kofler, MD Assistant Professor of Pathology Department of Pathology Title: “Neuropathologic Features of CTE”

1105AB 4-6PM

Nov 23, 2016 No Grand Rounds – Holiday Break

Nov 30, 2016 UPMC

Gwendolyn A. Sowa, MD, PhD Co-Director, Ferguson Laboratory for Orthopaedic Research Chair, Department of Physical Medicine & Rehabilitation sowaga@upmc.edu 412-648-6848 Title: “Updates in Low Back Pain: Challenges and Opportunities”

1105AB 4-6PM

Dec 7, 2016 In-House

Josif Stakic, MD Title: “Case Presentation of Progressive Neurologic Decline: Ataxia, Hearing Loss, Cognitive Decline” Patient will be present for the interview and examination

1105AB 4-6PM

Dec 14, 2016 Residents CPC Series Brian Hanrahan, MD Title: “First Time Seizure, When To Start AEDs and Mandatory Reporting” Mentor: Gena Ghearing, MD

1105AB 4-6PM

Dec 21, 2016 Recruit

Benjamin Tolchin, MD, MS Brigham and Women’s Hospital btolchin@partners.org Title: “Treatment Adherence and Outcomes in Psychogenic Nonepileptic Seizures"

1105AB 4-6PM Quarter sent to CME

Dec 28, 2016 No Grand Rounds – Holiday Break

THIRD QUARTER JAN-MAR 2017

Jan 4, 2017

Residents CPC Series Megan Mantica, MD Title: "Paraneoplastic Paradigm" Mentor: Dr. Drappatz (out of country) Dr. Lieberman involved at GR

1105AB 4-6PM

Jan 11, 2017 UPMC Paula Nave navep@upmc.edu Dawn Allan allanda@upmc.edu

Steven D. Shapiro, MD Executive Vice President, UPMC Chief Medical and Scientific Officer President, Health Services Division Distinguished Professor of Medicine Title: “Moore’s Law and Medicine: Embrace the Change”

1105AB 4-6PM

164

Jan 18, 2017 Residents CPC Series Stephanie Paolini, MD Title: “Marijuana in Neurology: What is the Evidence” Mentor: Robert Kaniecki

1105AB 4-6PM

Jan 25, 2017 Joint GR – Neurology Rock Heyman, MD (but due to a family emergency Dr. Zaydan gave his talk) Islam Zaydan, MD Title: Evaluation and Biopsy of CNS Inflammatory Lesions L. Dade Lunsford, M.D., F.A.C.S. Lars Leksell Professor of Neurological Surgery Distinguished Professor of Neurological Surgery The University of Pittsburgh Director, Center for Image Guided Neurosurgery Director, Neurosurgery Residency Program Chair, Technology and Innovative Practice Committee

Title: Brain Biopsy: When the Neurologist Calls…

1105AB 4-6PM

Feb 1, 2017 In-House

Robert G. Kaniecki, MD Director, the Headache Center Chief, Headache Division Director, Headache Fellowship Program Assistant Professor of Neurology University of Pittsburgh School of Medicine Title: “Cloudy with a Chance of Migraine”

1105AB 4-6PM

Feb 8, 2017 Residents CPC Series Jody Manners, MD Title: “A Lesson in Lesions: Transverse Myelitis and A Mimic”

1105AB 4-6PM

Feb 15, 2017 In-House

Ruchira Jha, MD Assistant Professor, CCM & Neurology Title: “Cerebral Edema in TBI: A Translational Assessment of the Role of Sulfonylurea Receptor 1”

1105AB 4-6PM

Feb 22, 2017 Residents CPC Series Alexis Steinberg, MD Title: "Can Seizing the Day Help Predict Tomorrow? The Role of EEG After Cardiac Arrest."

1105AB 4-6PM

Mar 1, 2017 In-House (Neurosurg)

Bradly Gross, MD Title: “Great Masqueraders: Cerebral Dural Arteriovenous Fistulas”

1105AB 4-6PM

Mar 8, 2017 In-House

Zongqi Xia, MD, PhD Title: “Multiple Sclerosis: Towards Precision Medicine in the Omics Era”

1105AB 4-6PM

Mar 15, 2017 Residents CPC Series Andrew Levin, MD Title: “Rekindling from Burnout in Neurology”

1105AB 4-6PM

165 Mar 22, 2017 In-House

Islam Zaydan, MD Title: “OCT in Neurology”

1105AB 4-6PM

Mar 29, 2017 Joint

Joint GR – Neurosurgery Neurology: Amber Van Laar, MD Neurology Lead Investigator, AAV2-AADC Gene Therapy for Parkinson’s Disease Department of Neurology, UPMC Neurosurgery: Mark Richardson, MD, PhD Principle Investigator, AAV2-AADC Gene Therapy for Parkinson’s Disease Department of Neurological Surgery, UPMC Title: “Phase 1 Results of Enzyme-Replacement Gene Therapy for Parkinson’s Disease”

1105AB 4-6PM

FOURTH QUARTER – APR-SEPT

Apr 5, 2017 Residents CPC Series Stella Lai, MD

Title: "Cognition in Children Born to

Women with Epilepsy"!

1105AB 4-6PM

Apr 12, 2017 VAPHS

Anne Van Cott, MD, Associate, Prof., Univ. of Pitt/VAPHS Hoby Hetherington, Visiting Prof. PhD, Dept of Radiology, Director MRRC Title: “Traumatic Brain Injury, Post-Traumatic Stress Disorder and 7TMRSI in Veterans”

1105AB 4-6PM

Apr 19, 2017 Residents CPC Series Alexandra Czap, MD Title: “Seeking Immunity: Novel Approaches to GBM”

1105AB 4-6PM

Apr 26, 2017 No Grand Rounds - AAN MEETING

May 3, 2017 Visiting

Paola Sandroni, MD, PhD Mayo Clinic/Rochester Title: “Postural Tachycardia Syndrome (POTS): Demystifying a Common Autonomic Disorder” 5:30pm Patient/Caregiver program: Title: "POTS: Unwrapping the Whole Package."

1105AB 4-6PM

May 10, 2017 Residents CPC Series Kiruba Dharaneeswaran, MD Title: “Flavi-ors of Acute Flaccid Paralysis in North America”

1105AB 4-6PM

May 17, 2017 CANCELLED 1105AB 4-6PM

May 24, 2017 In-House

Janet Waters, MD, MBA Title: “The Zika Virus and Its Impact on Pregnancy”

1105AB 4-6PM

166

May 31, 2017 Residents CPC Series

Deepak Soneji, MD, PhD Title: "Neurostimulants in Stroke Rehabilitation" Mentor: Dr. Jadhav has been the one helping me the most.

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SUMMER BREAK

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Departmental Bibliography 2015-2017

Cognitive and Behavioral Neurology Division

Oscar Lopez, MD, Professor and Division Chief

Espinosa A, Alegret M, Valero S, Vinyes-Junqué G, Hernández I, Mauleón A, Rosende-Roca M, Oscar

L. Lopez, MD Page 28 06/20/2015

Wang L, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L,

Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT,

Munger RG, Corcoran CD, Rogaeva E, Lin C, Dombroski BA, Cantwell LB, Partch A, Valladares O,

Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens

TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD; for the National

Institute on Aging–Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study; Alzheimer’s Disease

Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Barnes

LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve

BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC,

Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R,

Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M,

Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-

Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin L, Jun G,

Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah

JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson

DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee

AC, Mesulam MM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM,

Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M,

Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin

AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE,

Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ,

Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S,

Woltjer RL, Wright CB, Younkin SG, Yu C, Yu L. Rarity of the Alzheimer Disease-Protective APP A673T

Variant in the United States. JAMA Neurology 2015 Feb;72 (2):209-216 [PMCID: PMC4324097].

International Genomics of Alzheimer's Disease Consortium (IGAP): Jones L, Lambert JC, Wang LS, Choi

SH, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards R, Bellenguez C, Ibrahim-Verbaas CA,

Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis AL, Beecham GW, Grenier-Boley B, Russo G,

Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN,

Kamatani Y, Lin CF, Schmidt H, Kunkle BW, Dunstan ML, Ruiz A, Bihoreau MT, Reitz C, Pasquier F,

Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Becker JT, Gudnason V,

Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston

JA, Evans D, Lovestone S, Letteneur L, Kornhuber J, Tárraga L, Rubinsztein DC, Eiriksdottir G, Sleegers

K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Emilsson V, Brown K, Kamboh MI, Keller L, Barberger-

Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Kehoe P, Rogaeva

E, Gallacher J, St George-Hyslop P, Clarimon J, Lleò A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù

P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox N, Hardy J, Naranjo MCD, Razquin C, Bosco

P, Clarke R, Brayne C, Galimberti D, Mancuso M, MRC CFAS, Moebus S, Mecocci P, del Zompo M,

Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Benedetta Nacmias B, Gilbert JR, Mayhaus

M, Jessen F, Dichgans M, Lannfelt L, Hakonarson H, Pichler S,

169

Carrasquillo MM, Ingelsson M, Beekly D, Alavarez V, Zou F, Valladares O, Younkin SG, Coto E,

Hamilton-Nelson KL, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC,

Cantwell LB, Soininen H, Blacker D, Mead S, Mosley Jr. TH, Bennett DA, Harris TB, Fratiglioni L,

Chaudhry M, Wang X, Hasnain S, Demirci FY, Ganguli M, Lopez OL, Kamboh MI. Genetic Variation in

Imprinted Genes is Associated with Risk of Late-Onset Alzheimer’s disease. Journal of Alzheimer’s

Disease 2015 Jan 1; 44(3):989-994 [PMCID: PMC4324355].

Wang X, Lopez OL, Sweet RA, Becker JT, DeKosky ST, Barmada MM, Demirci Y, Kamboh MI. Genetic

determinants of survival in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease. 2015; 42

(2): 649-655. [PMCID: PMC4245313].

Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, Gach HM, Longstreth WT Jr, Teverovskiy L,

Kuller LH, Carmichael OT, Thompson PM. Physical activity, body mass index, and brain atrophy in

Alzheimer's disease. Neurobiology of Aging. 2015 Jan; 36 Suppl 1:S194-202 [PMCID: PMC4303036].

Riverol M, Becker JT, Lopez OL, Raji C, Thompson PM, Carmichael O, Gach HM, Longstreth W, Fried

L, Tracy RP, Kuller LH. Cystatin C predicts white matter lesions, gray matter volume and cognitive

function among cognitively normal elderly. Journal of Alzheimer’s Disease, 2015; 44(1):319-328 [PMCID:

PMC4297227].

Hohman T, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro

ML, Rajbhandary R, Vardarajan BD, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR,

Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin

CT, Green RC, Barnes LL, Cantwell LB, Fallin D, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta

KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM,

Lang R,. Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD,

Mayeux R,Haines JL, Thornton-Wells TA, for the Alzheimer Disease Genetics Consortium.Global and

Local Ancestry in African Americans: Implications for Alzheimer’s Disease Risk. Alzheimer’s &

Dementia, 2015 Jun 16. pii: S1552-5260(15)00190-9. doi: 10.1016/j.jalz.2015.02.012.

Hughes TM, Craft S, Lopez OL. The potential role of arterial stiffness in the pathogenesis of Alzheimer’s

disease. Neurodegenerative Diseases Management 2015 Apr;5 (2):121-135 [PMCID: PMC4423756].

Nadkarni N, Perera S, Hanlon JT, Lopez OL, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky

S, Yaffe K, Rosano C. Statins and brain integrity in older adults: Secondary analysis of the Health ABC

Study. Alzheimers & Dementia 2015 (Jan 12) [Epub ahead of print].

Chauhan G, Adams HH, Bis JC, Weinstein G, Yu L, Töglhofer AM, Smith AV, van der Lee S, Gottesman

RF, Thomson R, Wang J, Yang Q, Niessen WJ, Lopez OL, Becker JT, Phan TG, Beare RJ, Arfanakis K,

Fleischman D, Vernooij MW, Mazoyer B, Schmidt H, Srikanth V, Knopman DS, Jack, Jr. CR, Amouyel

P, Hofman A, DeCarli C, Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT, Mosley TH,

Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Association of Alzheimer disease GWAS loci

with MRI-markers of brain aging. Neurobiology of Aging 2015 Apr; 36(4):1765.e7-1765.e16 [PMCID:

PMC4391343].

Snitz BE, Cohen AD, Lopez OL, Nebes R, McDade E, Aizenstein HJ, Weissfeld LA, Price JA, Mathis

CA, Klunk WE. Neuroticism, subjective cognitive complaints and beta-amyloid deposition in older adults

without dementia. American Journal of Geriatric Psychiatry, 2015 Sep 23(9):985-993 [PMCID:

PMC4532656]

170

Jun G, Ibrahim-Verbaas CA, Vronskaya M, PhD, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS,

Bis JC, Bellenguez C, Lunetta KL, Harold D, Destefano AL, Grenier-Boley B, Beecham GW, Smith AV,

Escott-Price V, Chouraki V, Hamilton-Nelson KL, Gerrish A, Ikram M, Fievet N, Martin ER, Sims R,

Schmidt H, Kamatani Y, Valladares O, Ruiz A, Zelenika D, Foroud TM, Choi SH, Boland A, Kukull WA,

van der Lee SV, Pasquier F, Beekly D, Fitzpatrick AL, Hanon O, Barber R, Gudnason V, Campion D,

Bennett DA, Amin N, Berr C, Buxbaum JD, Lopez OL, Deramecourt V, Cantwell LB, Tárraga L, Dufouil

C, Crane PK, Eriksdottir G, Hannequin D, Evans D, Mosley TH, Letenneur L, Goate AM, De Jager P,

Jakobsdottir J, Dartigues JF, Kamboh MI, de Bruijn RFAG, Tzourio C, Larson EB, Rotter J, Montine TJ,

Nalls MA, Reiman E, Jonsson P, St. George-Hyslop P,Boada M, Wendland JR, Schmidt R, Winslow AR,

Younkin SG, Hofman A, Wilhelmsen KC, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C,

Launer LJ, Mayeux R, Lathrop M, Holmans P, Seshadri S, Pericak-Vance M, Amouyel P, Williams J, van

Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer’s disease locus located near the gene encoding

tau protein. Molecular Psychiatry. 2015 Feb 3. doi: 10.1038/mp.2014.188. [Epub ahead of print].

Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB,

Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C; for the Health ABC study. Objective

measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behavior

and Brain Research. 2015 Feb 2. pii: S0166-4328(15)00062-5. doi: 10.1016/j.bbr.2015.01.045 [PMCID:

PMC4369426].

McDade E, Boot BP, Riverol M, Lopez O.Cerebral bleed after shunt for normal pressure hydrocephalus

with cerebral amyloid angiopathy: Coincidence or consequence? Neurology in Clinical Practice 2015 Jun;5

(3):263-266.

Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin

M, Lahti J, van der Lee SJ, Hellard SL, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith

JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris S, Hill WD,

Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Au R, Becker JT, Beiser A, Berr C,

Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, L De Jager P, Dufouil C, Eriksson JG,

Espeseth T, Faul JD, Ford I, Generation Scotland, Gottesman RF, Griswold ME, Gudnason V, Harris TB,

Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SLR, Kochan N, Knopman DS, Kwok JB, Lambert

JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS,

Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P,

Rotter J, Schmidt H, Schuur M, Schofield P, Scott R, Steen VM, Stott DJ, van Swieten JC, Taylor KD,

Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF,

Wright MJ, Yang Q, Amieva H, Attia J, Bennett DA, Brodaty H, de Craen AJM, Hayward C, Ikram MA,

Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R,

Schofield PS, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, Visscher PM, van Duijn C, Launer

L, Fitzpatrick AL, Seshadri S, Mosley TH, Deary1 IJ, General cognitive function in middle and older age

is associated with the APOE/TOMM40 and 12q13.2 genomic regions: meta-analyses of genome-wide

association studies (N = 53 949) in the CHARGE Consortium. Molecular Psychiatry. 2015 Feb 20(2): 183-

192 [PMCID: PMC4356746].

Mosley T, Ibrahim-Verbaas C, Bressler J, Debette S, Schuur M, Smith A, Bis J, Davies G, Trompet S,

Smith J,Wolf C, Chibnik L, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek K, Zgaga L, Hoffmann P,

Karjalainen, Lahti J, Llewellyn D, Schmidt C, Mather S, Chouraki V, Sun Q, Resnick S, Rose L,

Oldmeadow C, Stewart M, Smith B, Gudnason V, Yang Q, Mirza S, Jukema J, De Jager P, Harris T,

Liewald D, Amin D, Coker L, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai J, Becker JT,

Jonsdottir M, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner S, Yaffe K, Lohman K, vanSwieten

JC, Kardia S, Knopman D, Meeks D, Heiss G, Holliday E, Schofield P, Tanaka T, Stott D, Wang J,

171

Ridker P, Gow AJ, Pattie A, Starr J, Hocking L, Armstrong N, McLachlan N, Shulman J, Porteous D,

Pilling L, Eiriksdottir G, Scott R, Kochan N, Palotie A, Hsieh YC, Eriksson J, Penman A, Gottesman R,

Oostra B, Yu L, DeStefano A, Beiser A, Garcia M, Rotter J, Nöthen M, Hofman A, Slagboom P,

Westendorp R, Buckley B, Wolf P, Uitterlinden A, Psaty B, Joergen Grabe H, Bandinelli S, Chasman D,

Grodstein F, Raikkonen K, Lambert JC, Generation Scotland, Price J, Sachdev P, Ferrucci L, Attia J, Rudan

I, Hayward , Wright A, Wilson J, Cichon S, Franke L, Schmidt H, Ding J, De Craen A, Fornage M, Bennett

D, Deary I, Ikram M, Launer L, Fitzpatrick A, Seshadri S, van Duijn C, Fawns-Ritchie C. GWAS for

executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry,

in press.

Zeifman LE, Eddy WF, Lopez OL, Kuller LH, Raji C, Thompson PM, Becker JT. Voxel level survival

analysis of grey matter volume and incident mild cognitive impairment or Alzheimer’s disease. Journal of

Alzheimer’s Disease, 2015: 2015; 46 (1):167-178 [PMCID: PMC4550581]

Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA,

Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C,

Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick

SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager

PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I,

Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann RS, Herms S, Nalls M, Zhao W, Turner ST, Yaffe

K, Lohman K, van Swieten JC, Kardia SL, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield

PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ,

McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC,

Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI,

Nöthen MM, Hofman A, Slagboom PE, Westendorp RG, Buckley BM, Wolf PA, Uitterlinden AG, Psaty

BM, Grabe HJ, Bandinelli S, Chasman DI, Grodstein F, Räikkönen K, Lambert JC, Porteous DJ;

Generation Scotland, Price JF, Sachdev PS, Ferrucci L, Attia JR, Rudan I, Hayward C, Wright AF, Wilson

JF, Cichon S, Franke L, Schmidt H, Ding J, de Craen AJ, Fornage M, Bennett DA, Deary IJ, Ikram MA,

Launer LJ, Fitzpatrick AL, Seshadri S, van Duijn CM, Mosley TH. GWAS for executive function and

processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry 2015 Apr 14. doi:

10.1038/mp.2015.37. [Epub ahead of print].

Chen YL, Rosario BL, Mowrey W, Laymon CM, Lu X, Lopez OL, Klunk WE, Lopresti BJ, Mathis CA,

Price JC. PiB Relative Delivery (R1) as a Proxy of Relative Cerebral Blood Flow: Quantitative Evaluation

Using Single Session [15O]Water and [11C]PiB PET. Journal of Nuclear Medicine 2015 [Epub ahead of

print].

Ghani M, Reitz C, Cheng R, Vardarajan NB, Jun G, Sato C, Naj A, Rajbhandary R,Sanf LS, Valladares O,

Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane K, Buxbaum JD, Murrell J Raj T,

Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LS, Candwell L, Fallin L, Go RDCP, Griffith

P, Obisesan TO,D, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS,

Goate AM, Byrd GS, Kukull WA, Foroud TM, Heines JL, Farrer LA, Pericak-Vance M, Lee JH,

Schellenberg JD, St George-Hyslop P, MD, Mayeux R,, Rogaeva E for the Alzheimer Disease Genetics

Consortium. Association of Long Runs of Homozygosity with Alzheimer’s Disease among African

Americans. JAMA-Neurology, Nov 1; 72 (11):1313-1323 [PMCID: PMC4641052]

Yau WYW, BS, Tudorascu DL, PhD, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu

LK, Snitz BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL. Longitudinal

change of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: Exploring

across-group and within-individual progression. Lancet Neurology, 2015 Aug; 14 (8):804-813 {PMCID:

PMC4519011]

170

Kaycee Sink K, Espeland MA, Castro CM, Church T, Cohen, R, Dodson JA, Guralnik J, Hendrie HC,

Jennings J, Katula J, Lopez OL, McDermott M, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S,

Williamson J, for the LIFE Study investigators. Effect of a 24-month physical activity intervention

compared to health education on cognitive outcomes in sedentary older adults: the LIFE Randomized Trial.

Journal of the American Medical Association (JAMA) 2015; 314(8): 781-790. [PMCID: PMC4698980].

Gregg NM, Kim AE, Gurol ME, Lopez OL, Aizenstein HJ, Price J, Mathis C, James J, Snitz B, Cohen A,

Kamboh MI, Weissfeld L, Klunk WE. Cerebral microbleeds are associated with reduced cerebral blood

flow and metabolism but not amyloid in the very elderly, JAMA-Neurology 2015 Sep;72 (9):1021-1028

[PMCID: PMC4724412].

Metti A, Aizenstein H, Yaffe K, Boudreau R, Newman A, Launer L, Gianaros P, Lopez OL, Saxton J, Ives

DG, Kritchevsky S, Vallejo AN, Rosano C. Trajectories of peripheral interleukin-6, structure of the

hippocampus, and cognitive impairment over 14 years in older adults. Neurobiology of Aging 2015 Nov;

36 (11): 3038-3044. [PMCID: PMC4718400].

Laugsand LE, Ix JH, Bartz TM, Djousse L, Kizer JR, Tracy RP, Dehghan A, Rexrode K, Lopez OL, Rimm

EB, Siscovick DS, O'Donnell CJ, Newman A, Mukamal KJ,Jensen MK. Fetuin-A and risk of coronary

heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7

prospective studies. Atherosclerosis 2015; 243: 44-52 [PMCID: PMC4609621].

Snitz BE, Lopez OL, McDade E, Becker JT, Cohen AD, Price JC, Mathis CA, Klunk WE. Amyloid-β

imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study.

Journal of Alzheimers Disease. 2015 Sep 24; 48: Suppl 1:S151-159 [PMCID: PMC4675050].

Goodheart AE, Tamburo E, Minhas D, Aizenstein HJ, McDade E, Snitz BE, Price JC, Mathis CA, Lopez

OL, Klunk WE, Cohen AD. Reduced binding of Pittsburgh Compound-B in areas of white matter

hyperintensities. Neuroimage, Clinical. 2015 Sep 29; 9:479-483 [PMCID: PMC4600857].

Kuller LH, Lopez OL, Becker JT, Chang Y, Newman AB. Risk of dementia and death in the long-term

follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study. Alzheimers & Dementia. 2016

Feb; 12(2):170-183. Epub 2015 Oct 28 [PMCID: PMC4744537].

Ahdidan J, Raji CA, DeYoe EA, Mathis J, Noe KØ, Rimestad J, Kjeldsen TK, Mosegaard J, Becker JT,

Lopez O.Quantitative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR

Imaging. Journal of Alzheimers Disease. 2015; 49(3): 723-732. doi: 10.3233/JAD-150559 [PMCID:

PMC4718601].

Mosley T, Ibrahim-Verbaas C, Bressler J, Debette S, Schuur M, Smith A, Bis J, Davies G, Trompet S,

Smith J,Wolf C, Chibnik L, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek K, Zgaga L, Hoffmann P,

Karjalainen, Lahti J, Llewellyn D, Schmidt C, Mather S, Chouraki V, Sun Q, Resnick S, Rose L,

Oldmeadow C, Stewart M, Smith B, Gudnason V, Yang Q, Mirza S, Jukema J, De Jager P, Harris T,

Liewald D, Amin D, Coker L, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai J, Becker JT,

Jonsdottir M, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner S, Yaffe K, Lohman K, vanSwieten

JC, Kardia S, Knopman D, Meeks D, Heiss G, Holliday E, Schofield P, Tanaka T, Stott D, Wang J, Ridker

P, Gow AJ, Pattie A, Starr J, Hocking L, Armstrong N, McLachlan N, Shulman J, Porteous D, Pilling L,

Eiriksdottir G, Scott R, Kochan N, Palotie A, Hsieh YC, Eriksson J, Penman A, Gottesman R, Oostra B,

Yu L, DeStefano A, Beiser A, Garcia M, Rotter J, Nöthen M, Hofman A, Slagboom P, Westendorp R,

Buckley B, Wolf P, Uitterlinden A, Psaty B, Joergen Grabe H, Bandinelli S, Chasman D, Grodstein F,

Raikkonen K, Lambert JC, Generation Scotland, Price J, Sachdev P, Ferrucci L, Attia J,

172

Rudan I, Hayward , Wright A, Wilson J, Cichon S, Franke L, Schmidt H, Ding J, De Craen A, Fornage M,

Bennett D, Deary I, Ikram M, Launer L, Fitzpatrick A, Seshadri S, van Duijn C, Fawns-Ritchie C. GWAS

for executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry. 2016 Feb;21(2):189-197; {Epub 2015 Apr 14}. [PMCID: PMC 4722802].

Jun G, Ibrahim-Verbaas CA, Vronskaya M, PhD, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS,

Bis JC, Bellenguez C, Lunetta KL, Harold D, Destefano AL, Grenier-Boley B, Beecham GW, Smith AV,

Escott-Price V, Chouraki V, Hamilton-Nelson KL, Gerrish A, Ikram M, Fievet N, Martin ER, Sims R,

Schmidt H, Kamatani Y, Valladares O, Ruiz A, Zelenika D, Foroud TM, Choi SH, Boland A, Kukull WA,

van der Lee SV, Pasquier F, Beekly D, Fitzpatrick AL, Hanon O, Barber R, Gudnason V, Campion D,

Bennett DA, Amin N, Berr C, Buxbaum JD, Lopez OL, Deramecourt V, Cantwell LB, Tárraga L, Dufouil

C, Crane PK, Eriksdottir G, Hannequin D, Evans D, Mosley TH, Letenneur L, Goate AM, De Jager P,

Jakobsdottir J, Dartigues JF, Kamboh MI, de Bruijn RFAG, Tzourio C, Larson EB, Rotter J, Montine TJ,

Nalls MA, Reiman E, Jonsson P, St. George-Hyslop P,Boada M, Wendland JR, Schmidt R, Winslow AR,

Younkin SG, Hofman A, Wilhelmsen KC, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C,

Launer LJ, Mayeux R, Lathrop M, Holmans P, Seshadri S, Pericak-Vance M, Amouyel

P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer’s disease locus located near

the gene encoding tau protein. Molecular Psychiatry. 2016 Jan;21(1): 108-117 {Epub 2015 Mar 17}

[PMCID: PMC4573764].

Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, Lopez OL, Mahoney J,

Pasic J, Tan ZS, Wills CD, Rhoads R, Yager J. The American Psychiatric Association Practice Guideline

on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients with Dementia. American Journal

of Psychiatry. 2016 May 1;173(5): 543-546. doi: 10.1176/appi.ajp.2015.173501.

Kirkwood CA, MacDonald ML, Schempf TA, Vatsavayi A, Ikonomovic MD, Ding Y, Sun M, Kofler JK,

Lopez OL, Yates N, Sweet RA. Vilip-1 Levels altered in brain tissue of individuals with Alzheimer’s

disease and frontotemporal lobar degeneration with prominent neuronal loss. Journal of Neuropathology

and Experimental Neurology 2016; Jan 14. pii: nlv018. [Epub ahead of print].

Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PM,

Kestenbaum BR, Kuller LH, Lopez OL, Becker JT, Langa KM, Henley WE, Lang IA, Ukoumunne OC,

Llewellyn DJ. Vitamin D and memory decline: Two population-based prospective studies. Journal of

Alzheimer’s Disease 2016, Jan 21; 50(4): 1099-1108. doi: 10.3233/JAD-150811..

Kuller LH, Lopez OL. Cardiovascular disease and dementia risk: an ever growing problem in an aging

population. Expert Review in Cardiovascular Therapy. 2016 May 4. [Epub ahead of print].

Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic

MD, Lopez OL, Fitz NF, Koldamova R, Yates NA. APOE*4 genotype is associated with altered levels of

glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to

moderate Alzheimer disease. Molecular Cell Proteomics. 2016 Apr 21. pii: mcp.M115.056580. [Epub

ahead of print].

Chauhan G, Arnold CR, Chu AY, Fornage M, Reyahi A, Bis JC, Havulinna AS, Sargurupremraj M, Smith

AV, Adams HHH, Choi SH, Trompet S, Garcia ME, Manichaikul A, Teumer A, Gustafsson S, Bartz TM,

Bellenguez C, Vidal JS, Jian X,r Kjartansson O, Wiggins KL, Satizabal C, Xue F, Ripatti S, Liu Y, Deelen

J, den Hoed M, Bevan S, Hopewell J, Malik R, Heckbert SR, Rice K, Smith NL, Levi C, Sharma P, Sudlow

CLM, AM, Cole JW, Schmidt R, Meschia J, Thijs V, Lindgren A, Melander O, Grewal RP, Sacco RL,

Rundek T, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Markus HS, Wasssertheil-

Smoller S, Lee JM, Pulit SL, Wong Q, Aparicio HJ, Engelter ST, Kloss M, Leys D,

173

Pezzini A, Buring JE, Ridker PM, Berr C, Dartigues JF, Hamsten A, Magnusson PK, Pedersen NL, Lannfelt

L, Lind L, Lindgren CM, Morris AP, Jimenez-Conde J, Montaner J, Radmanesh F, Slowik A, Woo D,

Hofman A, Koudstaal PJ, Portegies ML, Uitterlinden AG, de Craen AJM, Ford I, Jukema JW, Stott DJ,

Allen NB, Sale MM, Johnson AD, Grabe AG, Markus MRP, Schminke U, Boncoraglio GB, Clarke R,

Dallongeville J, Worrall BB, Rosand J, Kamatani Y, Lopez OL, Rotter JI, Nalls MA, Gottesman RF,

Griswold ME, Knopman DS, Windham G, Beiser A, deStefano A, Vartiainen E, French CR, Dichgans M,

Lathrop M, Gudnason V, Kurth T, Psaty BM, Harris TB, Rich SS, Schmidt CO, Salomaa V, Mosley TH,

Ingelsson E, van Duijn CM, Launer LJ, Lehmann OJ, Tzourio C, Rexrode K, Ikram MA, Carlsson P,

Chasman DI, Childs SJ, Longstreth WT, Seshadri S, Debette S. FOXF2, a novel risk locus for stroke and

small artery disease. Lancet-Neurology, 2016 Jun;15(7):695-707 [PMCID: PMC4927887]

Raji C, Merrill DA, Eyre H, Mallam S, Torosyan N, Erickson KI, Lopez OL, Becker JT, Carmichael OT,

Gach HM, Thompson PM, Longstreth W, Kuller LH. Longitudinal relationships between caloric

expenditure and gray matter in the Cardiovascular Health Study. Journal of Alzheimer’s Disease. 2016;52(2):719-729 [PMCID: PMC4927887].

Rodakowski, J., Reynolds III, C. F., Lopez, O. L., Butters, M. A., Dew, M. A., Skidmore E. R. Developing

a non-pharmacological intervention for individuals with Mild Cognitive Impairment. Journal of Applied

Gerontology 2016 Apr 22. pii: 0733464816645808. [Epub ahead of print]

Ding Y, MacDonald ML, Kirkwood CM, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez

OL, Fitz NF, Koldamova R, Yates NA, Sweet RA. APOE*4 genotype is associated with altered levels of

glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to

moderate Alzheimer’s disease. Molecular and Cellular Proteomics, in press.

Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR;

Kuller LH, Langa KM, Lopez OL, Llewellyn DJ. Vitamin D and Risk of Neuroimaging Abnormalities.

PloS One 2016 May 11;11(5): e0154896. doi: 10.1371/journal .pone.0154896.eCollection 2016 [PMCID:

PMC4864237

Kuller LH, Lopez OL, Mackey RH, Rosano C, Edmundowicz D, Becker JT, Newman AB. Subclinical

Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years. Journal of the American College of Cardiolology. 2016 Mar 8; 67 (9):1013-1022. doi: 10.1016/j.jacc.2015.12.034.

Sharma M, Fitzpatrick AL, Arnold AM, Chi G, Lopez OL, Jenny NS, DeKosky ST. Inflammatory

biomarkers and cognitive decline: The Ginkgo Evaluation of Memory Study. Journal of the American

Geriatric Society. 2016 Jun; 64(6):1171-1177.

Boeve BF, Dickson DW, Duda JE, Ferman TJ, Galasko DR, Galvin JE, Goldman JG, Growdon JH, Hurtig

HI, Kaufer DI, Kantarci K, Leverenz JB, Lippa CF, Lopez OL, McKeith IG, Singleton AB, Taylor A,

Tsuang D, Weintraub D, Zabetian CP. Arguing against the proposed definition changes of Parkinson’s

Disease. Movement Disorders, in press.

Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi

SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B,

Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn

C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S; International

Genomics of Alzheimer’s Project. Evaluation of a Genetic Risk Score to Improve Risk Prediction for

Alzheimer's Disease. Journal of Alzheimers Disease. 2016 Jun 18. [Epub ahead of print].

174

Chi GC, Fitzpatrick AL, Sharma M, Jenny NS, Lopez OL, DeKosky ST.Inflammatory Biomarkers Predict

Low Domain-Specific Cognitive Function in Older Adults. Journal of Gerontology: Medical Sciences,

2016, Aug 13, DOI: 10.1093/Gerona/glw155

Nadkarni NK, Perera S, Snitz BE, Price J, Mathis CA,Williamson JD, DeKosky ST, Klunk, WE, Lopez

OL. Cortical amyloid-beta and slow Gait in older adults without dementia: Influence of cognition and

APOE genotype. JAMA-Neurology, 2017 Nov 8; 87(19):1993-1999 [PMCID: PMC5209955].

Spauwen PJJ, Murphy RA, Jonsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MPJ, Lopez

OL, Gudnason V, Harris TB, Launer, LJ. Associations of fat and muscle tissue with cognitive status in a

population-based cohort of older adults: The AGES-Reykjavik Study. Age and Ageing, in press.

Reid KF, Walkup MP, Katula JA, Sink KM, Anton S, Axtell R, Kerwin DR, King AC, Kramer AF,

Miller ME, Myers V, Rosano C, Studenski SA, Lopez OL, Verghese J, Fielding RA, Williamson J.

Cognitive performance does not limit physical activity participation in the Lifestyle Interventions

and Independence for Elders pilot study (LIFE-P). Journal of Prevention of Alzheimer’s Disease

2016; 3(2): 66-67.

Grill JD, Apostolova L, Bullain S, Burns J, Cox C, Dick M, Kawas C, Kremen S, Lingler J, Lopez OL,

Mapstone M, Pierce A, Rabinovivi G, Roberts S, Sajjadi A, Teng E, Karlawish J. Communicating Mild

Cognitive Impairment diagnosis with and without amyloid imaging. Neurology, in press.

Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez

A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis

K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton

SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching

CRK, Chouraki V, Crivello F, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Giddaluru S, Goldman

AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Höhn D,

Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein

M, Kraemer B, Krämer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand A, Matarin

M, Karen A Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Maniega SM, Nho K, Nugent AC,

Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS,

Saremi A, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann

PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT,

Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der

Lee SJ, van der Meer D, Van Donkelaar MMJ, Van Eijk KR, van Erp TGM, van Rooij D, Walton E,

Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T,

Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA,

Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van

Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva

KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A,

Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager

PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A,

Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO,

Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C,

Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HHH, Green RC, Gruber O, Gudnason V, Guelfi

S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Hellard SL,

Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G,

Hosten N, Hottenga JJ, Huentelman M, Pol HEH, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson

EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I,

175

Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone

S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL,

Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH,

Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg

L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG,

Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco

RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A,

Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga

AW, Traynor B, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MCV, Van 't Ent D, Van

der Brug M, Van der Lugt A, Van der Wee NJA, Van Haren NEM, Van Tol MJ, Vardarajan BN, Vellas B,

Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW,

Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, The Alzheimer’s

Disease Neuroimaging Initiative, EPIGEN, IMAGEN, SYS, Martin NG, Van Duijn CM, Wright MJ,

Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM,

Ikram MA. Novel genetic loci associated with hippocampal volume, shape, and subfields. Nature

Communications 2017 Jan 18; 8:13624 [PMCID: PMC5253632].

Jakobsdóttir J, van der Lee SJ, Bis JC, Chouraki V, Shulman JM, Grove ML, Naj A, Vronskaya M,

DeStefano AL, Brody JA, Smith AV, Amin N, Ibrahim-Verbaas CA, Choi SH, Lopez OL, Beiser A, Ikram

MA, Garcia ME, Eirkisdottir G, Rice K, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T,

Cohorts for Heart and Aging Research in Genomic Epidemiology, Alzheimer’s Disease Genetic

Consortium, Genetic and Environmental Risk in Alzheimer’s Disease, International Genetics Alzheimer’s

Project, O’Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg J,

Boerwinkle E, Psaty B, Seshadri S, Gudnason V, van Duijn CM. Rare missense variant in TM2D3 is

associated with risk and onset of late-onset Alzheimer’s disease. PLOS Genetics 2016 Oct 20; 12(10):

e1006327 [PMCID: PMC5072721].

Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A,

Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini

S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A,

Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM,

Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan

NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold

ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz

D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano

M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter

R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM,

Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS,

Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL,

Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A,

Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D,

Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD,

Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos

A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S,

Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H,

Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W,

Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-

Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty

N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD,

Erk S, Espeseth T, Evans DA, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I,

Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL,

176

Göring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA,

Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra

PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Pol HE, Ikeda M, Ikram MK,

Jack CR Jr, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman

DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Longstreth WT Jr, Lopez OL,

Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon

FJ, Mecocci P, Melle I, Meyer-Lindenber A, Mohnke S, Mongomery GW, Morris DW, Mosley TH,

Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg

L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG,

Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco

RL, Sachdev PS, Saykin AJ, Schmidt R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya

SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A,

Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hernández MC,

Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van T Ent D, Van Tol

MJ, Vardarajan BN, Veltman DJ, Vernooij MW, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale

ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR,

Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ,

Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ikram MA, Thompson PM. Novel genetic

loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience 2016 Dec; 19 (12):1569-1582 [PMCID: PMC5253632].

Nadkarni NK, Lopez OL, Studentship SA, Snitz BE, Perera S, Erickson KI, Mathis CA, Nebeks RD,

Redfern M, Klunk WE, MD, PhD2,3. The Cognition-Mobility interface is associated with cerebral amyloid

in older adults without cognitive or mobility impairment. Journal of Gerontology Series A: Biological

sciences and Medical Sciences 2016 Nov 1. doi: 10.1093/ gerona/glw211.

Weamer EA, DeMichele-Sweet MA, Cloonan YK, Lopez OL, Sweet RA. Incident psychosis in subjects

with Mild Cognitive Impairment or Alzheimer's disease. Journal of Clinical Psychiatry. 2016 Dec; 77 (12):

e1564-e1569. doi: 10.4088/JCP.15m10617.

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SE, Lee, Vivianna EB, Van Deerlin M,

Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D,

Longfellow K, Yearout D, Kukul Wl, Keene CD, Montine TJ, Zabetian CP, Trojanowski JT.

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a

retrospective analysis. Lancet-Neurology 2017 Jan; 16(1):55-65 [PMCID: PMC5181646].

Boada M, Anaya F, Ortiz P, Olazarán J, Hernández I, Muñoz J, Buendia M, Alegret M, Lafuente A, Tárraga

L, Núñez L, Torres M, Grifols JR, Ferrer I, Obisesan TO, Shua-Haim JR, Lopez OL, Páez A. Plasma

exchange with 5% albumin alters Aβ levels in CSF and plasma, and improves cognition in Alzheimer’s

disease patients. Journal of Alzheimer’s Disease 2017, 56(1):129-143 [PMCID: PMC5240541].

Slachevsky A, Guzmán-Martínez L, Delgado C, Reyes P, Farías GA, Muñoz C, Bravo E, Farías M, Flores

P, Garrido C, Becker JT, López OL, Maccioni RB. TAU Platelets correlates with regional brain atrophy

in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease. 2017; 55 (4):1595-1603. doi:

10.3233/JAD-160652.

Spauwen PJJ, Murphy RA, Jonsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MPJ, Lopez

OL, Gudnason V, Harris TB, Launer, LJ. Associations of fat and muscle tissue with cognitive status in a

population-based cohort of older adults: The AGES-Reykjavik Study. Age and Ageing 2017 Mar 1; 46(2):

250-257 [PMCID:PMC5386007].

177

Ding J, Sigurŏsson S, Jónsson PV, Eirksdottir, Meirelles O, Kjartansson O, Lopez OL, van Buchem M,

Gudnason, Launer L. Space and location of cerebral microbleeds, cognitive decline, and dementia in the

community: The AGES-Reykjavik Study. Neurology, 2017. May 30;88 (22):2089-2097.

Nadkarni NK, Perera S, Snitz BE, Price J, Mathis CA, Williamson JD, DeKosky ST, Klunk, WE, Lopez

OL. Cortical amyloid-beta and slow gait in older adults without dementia: Influence of cognition and

APOE genotype. JAMA Neurology 2017 Jan 1; 74 (1):82-90. doi: 10.1001 /jamaneurol.2016.3474.

Kassen AM, Ganguli M, Yaffee K, Hanlon JT, Lopez OL, Wilson JW, Cauley JA. Anxiety symptoms and

risk of cognitive decline in older community-dwelling men: results from the Osteoporotic Fractures in Men

Study. International Psychogeriatric 2017 Apr 9:1-9. doi: 10.1017/S104161021700045X.

Kuźma E, Airdrie J, Littlejohns TJ, Lourida I, Thompson-Coon J, Lang IA, Scrobotovici M, Thacker E,

Fitzpatrick A, Kuller LH, Lopez OL, Longstreth WT, Ukoumunne OC, Llewellyn DJ. Coronary artery

bypass graft surgery and the risk of dementia: A prospective study and meta-analysis. Alzheimer’s Disease

and Associated Disorders 2017 Mar 3. doi: 10.1097/WAD. 0000000000000191. [Epub ahead of print].

DeMichele-Sweet MA, Weamer EA, Klei L, Vrana DT, Hollingshead DJ, Seltman HJ, Sims R, Foroud T,

Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL,

Kamboh MI, Devlin B, Sweet RA. Genetic risk for schizophrenia and psychosis in Alzheimer’s disease.

Biological Psychiatry, in press.

Stillman CM, Lopez OL, Becker JT, Kuller LH, Mehta PD, Tracy RP, Erickson KI. Physical activity

reduces plasma β amyloid levels and decreases risk for cognitive impairment in older adults: Longitudinal

results from the Cardiovascular Health Study. Annals of Clinical and Translational Neurology, 2017 Apr

14;4 (5):284-291 [PMCID:PMC5420805].

Kassem AM, Hanlon J, Ganguli M, Yaffe K, Wilson JW, Lopez OL, Ayonayon OE, O'Hare C, Satterfield

S, Harris TB, Cauley JA. Trends and gender-specific predictors of anxiolytic and antidepressant

medications use in older adults. Aging and Mental Health, in press.

Grill JD, Apostolova L, Bullain S, Burns J, Cox C, Dick M, Kawas C, Kremen S, Lingler J, Lopez OL,

Mapstone M, Pierce A, Rabinovivi G, Roberts S, Sajjadi A, Teng E, Karlawish J. Communicating Mild

Cognitive Impairment diagnosis with and without amyloid imaging. Alzheimer’s Research & Therapy

2017, in press.

Palta P, Carlson MC, Crum RM, Colantuoni E, Sharrett AR, Yasar S, Nahin R, DeKosky ST, Snitz B,

Lopez OL, Williamson JD, Furberg CD, Rapp SR, Golden SH. Diabetes and Cognitive Decline in Older

Adults: The Ginkgo Evaluation of Memory Study. Journal of Gerontology: Medical Sciences, in press.

Ding J, Sigurðsson S, Jónsson PV, Eiriksdottir G, Charidimou A, Lopez OL, van Buchem MA, Guðnason

V, Launer LJ. Large MRI-visible perivascular spaces, cerebral small vessel disease progression and risk of

dementia: the AGES-Reykjavik Study. JAMA-Neurology, in press.

Petersen RC, Lopez OL, Armstrong M, Getchius TS, Ganguli M, Gloss, D, Marson D, Pringsheim T, Day

GS, Sager M, Stevens JC, Rae-Grant AD. American Academy of Neurology Practice guideline for mild

cognitive impairment. Neurology, in press.

Zhao J, Tudorascu DL, Lopez OL, Cohen AD, Price JC, Mathis CA, Aizenstein HJ, Kuller LH, DeKosky

ST, Klunk WE, Snitz BE. Amyloid-beta deposition and suspected non-Alzheimer

178

pathophysiology exhibit different cognitive decline patterns over 12 years in the oldest-old without

dementia. JAMA-Neurology, in press.

Beth Snitz, PhD

Snitz BE, Weissfeld LA, Cohen AD, Lopez OL, Nebes RD, Aizenstein HJ, McDade E, Price JC, Mathis

CM, Klunk WE. Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal

older adults. American Journal of Geriatric Psychiatry, in press, doi:10.1016/j.jagp.2015.01.008.

Snitz BE, Lopez OL, McDade E, Becker JT, Cohen AD, Price JC, Mathis CA, Klunk WE. Amyloid beta

imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study.

Journal of Alzheimer’s Disease, 2015, 48, S151-S159.

Rosenthal SL, Bamne MN, Wang X, Berman S, Snitz BE, Klunk WE, Sweet RA, Demirci FY, Lopez OL,

Kamboh MI. More evidence for association of a rare TRAM2 mutation (R47H) with Alzheimer’s disease

risk. Neurobiology of Aging. 2015 Aug; 36 (8):2443.e21-6. PMCID: PMC4465085. PMIC: 26058841.

Doi:10.1016/j.neurogioaging.2015.04.012.

Yau WW, Tudorascu DL, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu LK, Snitz

BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL, Klunk WE. Longituinal

assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a

prospective cohort study. The Lancet. Neurology. 2015 June 29. PMIC: 26139022. Doi: 10.1016/S1474-

4422(15)00135-0.

Snitz, BE, Small, B. J., Wang, T., Chang, C. C. H., Hughes, T. F., & Ganguli, M. Do subjective memory

complaints lead or follow objective cognitive change? A five-year population study of temporal influence.

Journal of the International Neuropsychological Society, 2015, 21(09), 732-742.

Nimgaonkar, V. L., Yolken, R. H., Wang, T., Chung-Chou, H. C., McClain, L., McDade, E., Snitz BE, &

Ganguli, M. Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-

based, Aging Cohort. Alzheimer Disease and Associated Disorders. 2015.

doi:10.1097/WAD.0000000000000133.

Rabin, L. A., Smart, C. M., Crane, P. K., Amariglio, R. E., Berman, L. M., Boada, M., Buckley, R.,

Chetalat, G., Dubois, B., Ellis, K.A., Gifford, K.A., Jefferson, A.L., Jessen, F., Katz, M.J., Lipton, R.B.,

Perrotin, A., Petersen, R.C., Rami, L., Reisberg, B., Rentz, D.M., Reidel-Heller, SG., Risacher, S.L.,

Rodriquez, O., Sachdev, P.S., Saykin, A.J., Slavin, M.J., Snitz, B.E., Sperling, R.A., Tandetnik, C., Van

der Flier, W.M., Wagner, M., Wolfsbruber, S., & Sikkes. Subjective Cognitive Decline in Older Adults:

An Overview of Self-Report Measures Used Across 19 International Research Studies. Journal of

Alzheimers Disease, 2015, 48, S63-S86. doi:10.3233/JAD-150154.

Callahan, K. E., Lovato, J. F., Miller, M. E., Easterling, D., Snitz, B., & Williamson, J. D. Associations

Between Mild Cognitive Impairment and Hospitalization and Readmission. Journal of the American Geriatrics Society, 2015, 63(9), 1880-1885.

Gregg, N. M., Kim, A. E., Gurol, M. E., Lopez, O. L., Aizenstein, H. J., Price, J. C., Mathis, C.A., James,

J.A. Snitz, B.E., Cohen, A.D., Kamboh, I., Minhas, D., Weissfeld, L.A., Tamburo, E., & Klunk, W. E.

Incidental cerebral microbleeds and cerebral blood flow in elderly individuals. JAMA Neurology, 2015,

72(9), 1021-1028. doi:10.1001/jamaneurol.2015.1359.

Fowler, N. R., Morrow, L., Chiappetta, L., Snitz, B., Huber, K., Rodriguez, E., & Saxton, J. Cognitive

testing in older primary care patients: A cluster-randomized trial. Alzheimer's and Dementia: Diagnosis,

Assessment and Disease Monitoring, 2015, 1(3), 349-357. doi:10.1016/j.dadm.2015.06.009.

179

Wollam, M. E., Weinstein, A. M., Saxton, J. A., Morrow, L., Snitz, B., Fowler, N. R., . . . Erickson, K. I.

Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research, 2015.

doi:10.1155/2015/267062.

Goodheart, A. E., Tamburo, E., Minhas, D., Aizenstein, H. J., McDade, E., Snitz, B. E., . . . Cohen, A. D.

Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities. Neuroimagine-Clinical, 2015, 9, 479-483. doi:10.1016/j.nicl.2015.09.009.

McDade, E., Sun, Z., Lee, C. -W., Snitz, B., Hughes, T., Chang, C. -C. H., & Ganguli, M. The association

between pulse pressure change and cognition in late life: Age and where you start matters. Alzheimers

Dement (Amst), 2016, 4, 56-66. doi:10.1016/j.dadm.2016.03.008.

Graziane, J. A., Beer, J. C., Snitz, B. E., Chang, C. -C. H., & Ganguli, M. Dual Trajectories of Depression

and Cognition: A Longitudinal Population-Based Study. American Journal of Geriatric Psychiatry, 2016,

24(5), 364-373. doi:10.1016/j.jagp.2015.08.001.

Mattos, M. K., Snitz, B. E., Lingler, J. H., Burke, L. E., Novosel, L. M., & Sereika, S. M. Older Rural- and

Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health. 2016

doi:10.1111/jrh.12189.

Epilepsy Division

Anto Bagić, MD, PhD, Associate Professor and Chief, Epilepsy Division

Bagić A, Ebersole J. Does MEG/MSI Dipole Variability Mean Unreliability? Bagić A, Ebersole JS. Does

MEG/MSI dipole variability mean unreliability? Clin Neurophysiol 2015;126(1):209-11.

Maestu F. Peña JM, Garces P, Gonzalez s, Bajo R, Bagic A, Cuesta P, Funke M, Mäkelä J, Menasalvas E,

Nakamura A, Parkkonen L, Lopez ME, del Pozo F, Sudre S, Zamrini E, Pekkonnen E, Henson H, Becker

J. A Multicenter Study of the Early Detection of Synaptic Dysfunction in Mild Cognitive Impairment using

Magnetoencephalography-derived Functional Connectivity. Neuroimage Clin 2015;9:103-9.

Hendrickson R, Popescu A, Ghearing G, Bagić A. Thoughts, Emotions and Dissociative Features

Differentiate Patients with Epilepsy and Psychogenic Nonepileptic Spells (PNES). Epilepsy Behav

2015;51:158-62.

Bagić A. Look Back To Leap Forward: Additional Emerging Role Of Magnetoencephalography (MEG)

In Nonlesional Epilepsy. Clin Neurophysiol 2016;127(1):60-6.

Fisher RS, Afra P, Macken M, Daniela N. Minecan DN, Bagić A, Benbadis SR, Helmers SL, Sinha SR,

Slater J, Treiman D, Begnaud J, Raman P, Najimipour B. Performance and Clinical Outcomes of a Vagus

Nerve Stimulator triggered by Ictal Tachycardia: The US E-37 Trial. Neuromodulation 2016;19(2):188-

95.

Zhang J, Li X, Foldes S, Wang W, Collinger J, Weber DJ, Bagić A. Region-of-Interest-Constrained

Discriminant Analysis for MEG Decoding. IEEE Trans Biomed Eng 2016;63(1):30-42.

Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bagic A, Wagner

D, Richardson RM. Short-term neurocognitive outcomes following anterior temporal lobectomy. Epilepsy

Behav 2016, EB-16-144R1, in press.

180

Arun Antony, MD, Assistant Professor

Arun Angelo Patil, Arun Antony, Richard Andrews. Efficacy of Vagal nerve stimulation after multiple

sub pial transection in Epilepsy. World federation of Neurology

Arun Antony, AV Alexopoulos, JA Gonzalez-Martinez, JC Mosher, L Jehi. Functional Connectivity

Estimated from Intracranial EEG Predicts Surgical Outcome in Intractable Temporal Lobe Epilepsy, PloS

one 8 (10), e77916.

Philip S Lee, Jamie Pardini, Rick Hendrickson, Vincent Destefino, Alexandra Popescu, Gena Ghearing,

Arun Antony, Jullie Pan, MD, Anto Bajic, Danielle Wagner, Robert M Richardson. Short-term

neurocognitive outcomes following anterior temporal lobectomy. Epilepsy and behavior September 2016 (62):140–146. Sanjay Singh, Ram Sankaraneni, Arun Antony. Evidence Based Guidelines for the Management of

Epilepsy. Neurology India 2017: 65 (7); S6-11.

Zulfi Haneef, Sharon Chiang, Holly Rutherford, Arun Antony. A Survey of Neruophysiology Fellows in

the United States. Journal of Clinical Neurophysiology 2017: 34 (2) 179-186.

Thomas A Wozny, BSc; Witold J Lipski, PhD; Ahmad Alhourani, MD; Efstathios D Kondylis, BSE; Arun

Antony, Robert Mark Richardson. Effects of hippocampal low-fequency stimulation in idiopathic non-

human primate epilepsy assessed bia a remote-sensing-enabled neurostimulator. Journal of Experimental

Neurology.2017 (2094) 68-77.

Joanna Fong, Assistant Professor

Nancy Foldvary-Schaefer, Joanna S. Fong, Shannon Morrison, Lu Wang, James Bena. Lacosamide

Tolerability in Patients with Partial-Onset Seizures: Impact of Planned Reduction and Mechanism of

Action of Concomitant Antiepileptic Drugs. Epilepy Behav. 2016 Apr;57:155-160.

Gena Ghearing, MD, Assistant Professor

Kenmuir C, Richardson M, Ghearing G. Surgical treatment for medically refractory focal epilepsy in a

patient with fragile X syndrome. Brain Dev. 2015 Apr 7. pii: S0387-7604(15)00034-0. doi:

10.1016/j.braindev.2015.02.009. [Epub ahead of print]

Rick Hendrickson, PhD, Assistant Professor

Hendrickson, R., Popescu, A., Ghearing, G. & Bagic, A. (2015). Thoughts, emotions and dissociative

features differentiate patients with epilepsy from patients with psychogenic nonepileptic spells. Epilepsy & Behavior, 51, 158-62.

Lee, PS, Pardini, J., Hendrickson, R., Destefino, V., Popescu, A., Ghearing, G., Antony, A., Pan, J., Bagic,

A., Richardson, R.M. (accepted by Epilepsy & Behavior) Short-term neurocognitive outcomes following

anterior temporal lobectomy.

Alexandra Urban, MD, Assistant Professor

Edilberto Amorim, MD1; Jon C. Rittenberger, MD2; Maria E. Baldwin, MD1; Clifton W. Callaway, MD2;

Alexandra Popescu, MD1 And the Post Cardiac Arrest Service. Malignant EEG patterns in

181

cardiac arrest patients treated with targeted temperature management who survive to hospital discharge.

Resuscitation 2015, May:90:127-32.

Hendrickson R, Popescu A, Ghearing G, Bagic A. Thoughts, emotions, and dissociative features

differentiate patients with epilepsy from patients with psychogenic nonepileptic spells (PNESs). Epilepsy

Behav. 2015 Oct;51:158-62.

Elmer J, Rittenberger JC, Faro J, Molyneaux BJ, Popescu A, Callaway CW, Baldwin M; Pittsburgh Post-

Cardiac Arrest Service. Clinically distinct electroencephalographic phenotypes of early myoclonus after

cardiac arrest: EEG Phenotypes of PAMM. Ann Neurol. 2016 Jun 28. doi: 10.1002/ana.24697. [Epub

ahead of print]

Jamie Pardini, PhD; Rick Hendrickson, PhD; Vincent Destefino, BA; Alexandra Popescu, MD; Gena

Ghearing, MD; Arun Antony, MD; Jullie Pan, MD, PhD; Anto Bajic, MD, PhD; Danielle Wagner, PA-C;

Robert M Richardson, MD, PhD. Short-term neurocognitive outcomes following anterior temporal

lobectomy. Accepted in Epilepsy & Behavior.

Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bagic A,

Wagner D, Richardson RM.. Short-term neurocognitive outcomes following anterior temporal lobectomy.

Epilepsy Behav. 2016 Sep;62:140-6. doi: 10.1016/j.yebeh.2016.06.019

Amorim E, Rittenberger JC, Zheng JJ, Westover MB, Baldwin ME, Callaway CW, Popescu A; Pittsburgh

Post Cardiac Arrest Service. Continuous EEG monitoring enhances multimodal outcome prediction in

hypoxic-ischemic brain injury. Resuscitation. 2016 Dec;109: 121-126. doi: 10.1016/ j.resuscitation.

2016.08.012

Ghearing G, Abramovici S, Baldwin M, Urban A. Misleading EEG Lateralization Associated with

Midline Shift. Journal of Clinical Neurophysiology. 2017 Jul 4.. [Epub ahead of print]

Anne Van Cott, MD, Associate Professor

Rohde NN, Baca CB, Van Cott AC, Parko KL, Amuan ME, Pugh MJ. Antiepileptic drug prescribing

patterns in Iraq and Afghanistan war veterans with epilepsy. Epilepsy Behav.2015 46:133-9.

Pugh MJ, Van Cott AC, Amuan M, Baca C, Rutecki P, Zack MM, Kobau R. Epilepsy Among Iraq and

Afghanistan War Veterans-United States, 2002-2015. MMWR 2016 65 (44) 1224-1227.

Atalib H, Cavazos J, Pugh MJ, Hussain A, Kelly-Foxworth P, Tran T, Krumholz A, LaFrance WC, Lopez

R, Rutecki P, Van Cott A for the VA Epilepsy Centers of Excellence. Providing Quality Epilepsy Care

for Veteran. Fed Pract. 2016 September; 33 (9): 26-32.

Kontos AP, Van Cott AC, Roberts J, Pan JW, Kelly MB, McAllister-Deitrick J, Hetherington HP.

Clinical Biomarkers and Magnetic Resonance Spectroscopic Imaging Abnormalities in Veterans with

Blast Mild Traumatic Brain Injury and Post-traumatic Stress Disorder. Military Medicine

General Division

Neil Busis, MD, Clinical Professor

Busis NA, Dorsey ER. Shining light on Medicare’s values: The Medicare physician data release.

Neurology. 2015; 84:1730–1731.

182

Yanofsky CS, Busis NA. To revitalize neurology we need to address physician burnout. Neurology. 2015;

84(23):2384-5.

Satya-Murti S, Busis NA. Chronic care management codes: a small step in the right direction. Neurol

Clin Pract. 2015; 5:371-373.

Rolan TD, Busis NA, Dorsey ER. Shining light on Medicare's values: The Medicare physician data

release/ Author Response. Neurology. 2015; 85:1636.

Franklin GM, Busis NA. The AAN and the triple aim. Neurology. 2016; 86:114-5.

Busis NA, Franklin GM. The AAN's Axon Registry: Mastering how we are measured. Neurology. 2016;

87:2180–2181.

Busis NA, Shanafelt TD, Keran CM, Levin KH, Schwarz HB, Molano JR, Vidic TR, Kass JS, Miyasaki

JM, Sloan JA, Cascino TL. Burnout, career satisfaction, and well-being among US neurologists in 2016.

Neurology. 2017; 88:797–808.

Levin KH, Shanafelt TD, Keran CM, Busis NA, Foster LA, Molano JR, O’Donovan CA, Ratliff JB,

Schwarz HB, Sloan JA, Cascino TL. Burnout, career satisfaction, and well-being among US neurology

residents and fellows in 2016. Neurology. 2017; 89:492-501.

Busis NA, Shanafelt TD, Keran CM, Levin KH, Schwarz HB, Molano JR, Vidic TR, Kass JS, Miyasaki

JM, Sloan JA, Cascino TL. Author response: Burnout, career satisfaction, and well-being among US

neurologists in 2016. Neurology. 2017; 89:1650-1651.

Miyasaki JM, Rheaume C, Gulya L, Ellenstein A, Schwarz HB, Vidic TR, Shanafelt TD, Cascino TL,

Keran CM, Busis NA. Qualitative study of burnout, career satisfaction, and well-being among US

neurologists in 2016. Neurology. 2017; 89:1730-1738.

Angela Lu, MD, Clinical Associate Professor

Gonzalez NL, Puwanant A, Lu A, Marks SM, and Zivkovic SA. Myasthenia triggered by immune checkpoint

inhibitors: new case and literature review. Neuromuscular Disorders, 2017; 27 (3) 266-268.

Janet Waters, MD

Waters JH, Dyga RM, Waters JFR, Yazer MH. The volume of returned RBCs in a Large Blood Salvage

Program: Where does it all go? Transfusion. [Epub ahead of print].

Movement Disorders Division

Sarah Berman, MD, PhD, Assistant Professor

Van Laar VS, Roy N, Liu A, Rajprohat S, Arnold B, Dukes AA, Holbein CD, and Berman SB. (2015)

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of

Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol. Dis, 74: 180-193.

Rosenthal SL, Bamne MN, Wang X, Berman S, Snitz BE, Klunk WE, Sweet RA, Demirci FY,

Lopez OL, and Kamboh MI (2015). More evidence for association of a rare TREM2 mutation

(R47H) with Alzheimer’s disease risk. Neurobiol. Aging, 36 (8):2443.e21-6.

183

Van Laar VS, Berman SB, and Hastings TG (2016). Mic60/mitofilin overexpression alters

mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and

rotenone. Neurobiol. Dis., (91) 247-261.

Dukes AD, Bai Q, Van Laar VS, Zhou Y, Ilin V, David CN, Agim ZS, Bonkowsky JL, Cannon JR,

Watkins SC, St. Croix CM, *Burton EA, and *Berman SB (2016) Live imaging of mitochondrial

dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial

transport following MPP+ exposure. Neurobiol. Dis., (95:238-49). *Co-corresponding authors.

Edward A. Burton, MD, DPhil, Assistant Professor

Zharikov, A., Cannon, J. R., Tapias, V., Bai, Q., Horowitz, M. P., Shah, V., El Ayadi, A., Hastings, T. G.,

Greenamyre, J. T., *Burton, E. A. (2015) shRNA targeting α-synuclein prevents neurodegeneration in a

Parkinson’s disease model. Journal of Clinical Investigation. 125(7):2721-2735.

[Featured as a “Scientific Show Stopper” with accompanying commentary on JCI website]

Keatinge, M., Bui, H., Menke, A., Chen, Y.-C., Sokol, A. M., Bai, Q., Ellett, F., Da Costa, M., Burke, D.,

Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.-S.,

Fleming, A., Schapira, A., Renshaw, S., Highley, J., R., Chacinska, A., Panula, P., Burton, E. A., O'Neil,

M., Bandmann, O. (2015) Early inflammation and alpha-synuclein-independent cell death in

glucocerebrosidase 1 deficient Danio rerio. Human Molecular Genetics. 24(23):6640-52.

Mahoney, S., Najera, M., Bai, Q., Burton, E. A., Veser, G. (2016) The developmental toxicity of complex

silica-embedded nickel nanoparticles is determined by their physicochemical properties. PLoS ONE

11(3):e0152010.

Di Maio, R. Barrett, P. J., Hoffman, E. K., Barrett, C. W., Zharikov, A., Borah, A., Hu, X., McCoy, J.,

Chu, C. T., Burton, E. A., Hastings, T. G., Greenamyre, J. T. (2016) α-Synuclein binds TOM20 and

inhibits mitochondrial protein import in Parkinson’s disease. Science Translational Medicine.

8:342ra78:1-14.

Dukes, A. D., Bai, Q., Van Laar, V. S., Zhou, Y., Ilin, V., David, C. N., Agim, Z. S., Bonkowsky, J.

L., Cannon, J. R., Watkins, S. C., St. Croix, C. M., *Burton, E. A. and Berman, S. B. (2016) Live

imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early

reversal of mitochondrial transport following MPP+ exposure. Neurobiology of Disease 95:238-249

[Burton E. A. and Berman S. B. are joint corresponding authors]

Burton, C. E., Zhou, Y., Bai, Q. & *Burton, E. A. (2017). Spectral properties of the zebrafish visual

motor response. Neurosci Lett 646, 62-67.

Sandulescu, M. C., and *Burton, E. A. (2017) Chapter 13: Movement Disorders Emergencies and

Movement Disorders in the ICU. In Neurocritical Care (Pittsburgh Critical Care Series), B.

Molyneux and L. Shutter eds. (Oxford: Oxford University Press) In press

Franca Cambi, MD, PhD, Professor of Neurology

Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz

K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ,

Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N,

184

Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST,

Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS,

Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills

AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a

randomized clinical trial. JAMA. 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120.

GM1 ganglioside in Parkinson’sdisease: Pilot study of effects on dopamine transporter binding. Schneider

JS, Cambi F, Gollomp SM, Kuwabara H, Brašić JR, Leiby B, Sendek S, Wong DF. J Neurol Sci. 2015

Sep 15;356(1-2):118-23. doi: 10.1016/j.jns.2015.06.028. Epub 2015 Jun 16.

Pioglitazone in early Parkinson’s disease: a phase 2, multicentre, double-blind, randomised trial. NINDS

Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators. Lancet Neurol. 2015

Aug;14(8):795-803. doi: 10.1016/S1474-4422(15)00144-1. Epub 2015 Jun 23.

Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease. Augustine EF, Pérez A, Dhall

R, Umeh CC, Videnovic A, Cambi F, Wills AM, Elm JJ, Zweig RM, Shulman LM, Nance MA,

Bainbridge J, Suchowersky O. PLoS One. 2015 Jul 14;10(7):e0133002. doi:

10.1371/journal.pone.0133002. eCollection 2015.

Distinct and shared molecular targets and functions of ALS-associated TDP43, FUS and TAF15 revealed

by comprehensive multi-system integrative analyses. Kapeli K, Pratt G, Vu A, Martinez F, Freese P,

Lambert NJ, Hutt K, Sundaraman B, Huelga SC, Chun S, Liang S, Cheang J, Donohue JP, Shiue L, Zhu

H, Cambi F, Kasarskis E, Ares M Jr, Burge CB, Rigo F, Yeo GW. In Press Nature Communications

2016.

John Timothy Greenamyre, MD, PhD – Professor

Tyurina YY, Polimova AM, Maciel E, Tyurin VA, Kapralova VI, Winnica DE, Vikulina A,

Domingues RM, Sanders LH, Bayir H, Greenamyre JT, Kagan VE, LC/MS analysis of cardiolipins

in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in

Parkinson’s disease, Free Rad Res 5:1-11, 2015. PMC4430340

Zharikov A, Cannon JR, Tapias V, Bai Q, Horowitz M, Shah V, El Ayadi A, Hastings TG,

Greenamyre JT, Burton EA, shRNA targeting α-synuclein prevents neurodegeneration in a

Parkinson’s disease model, J Clin Invest 125:2721-35, 2015. PMC4563670

Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT,

Burton EA, Hastings TG, Greenamyre JT. α-Synuclein binds to TOM20 and inhibits mitochondrial

protein import in Parkinson's disease. Sci Transl Med 2016;8:342ra78. PMC5016095

Huntington Study Group PI, Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman

MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, Siemers E,

Tanner C, Mallonee W, Suter G, Dubinsky R, Gray C, Nance M, Bundlie S, Radtke D, Kostyk S,

Baic C, Caress J, Walker F, Hunt V, O'Neill C, Chouinard S, Factor S, Greenamyre T et al. Clinical-

Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS):

Implications for Clinical Trials. JAMA Neurology 73:102-10, 2016.

Sahoo B, Arduini I, Drombosky KW, Kodali R, Sanders LH, Greenamyre JT, Wetzel R. Folding

Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No

Detectable Monomer. PLoS One. 2016;11:e0155747. PMC4894636

185

Houman Homayoun, MD, Assistant Professor

Homayoun, H (2016) Movement Disorders and Neuromuscular Disorders sections. In MKSAP17

Neurology, American Academy of Physicians,.

Neurocritical Care

Bradley Molyneaux, M.D., PhD, Assistant Professor

Aghaebrahim, A., Jadhav, A.P., Saeed, Y, Totoraitis, R., Jankowitz, B.T., Jovin, T., and Molyneaux,

Molyneaux, B.J.*, Goff, L.A.*, Brettler, A.C., Chen, H.H., Hrvatin, S., Rinn, J.L., and Arlotta, P. 2015.

DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection

in neocortex. Neuron. 85:275-288. (with video abstract)

Callaway, C.W., Elmer, J., Guyette, F.X., Molyneaux, B.J., Anderson, K.B., Empey, P.E., Gerstel, S.J.,

Holquist, K., Repine, M.J., and Rittenberger, J.C. (2015). Dexmedetomidine Reduces Shivering during

Mild Hypothermia in Waking Subjects. PLoS ONE 10, e0129709.

Ruchira Menka Jha, MD, Clinical Instructor

Chrenek R, Magnotti LM, Herrera GR, Jha RM, Cardozo DL. Characteriation of the filum terminale as

a neural progenitor cell niche in both rats and humans. J Comp Neurol: August 2016 (Epub ahead of print).

Topcuoglu MA, Jha RM, George J, Frosch MP, Singhal AB. Hemorrhagic Primary CNS Angiitis and

Vasoconstrictive Drug Exposure. Neurology: Clinical Practice, in press.

Jha RM, Puccio A, Chou S, Chang CCH, Wallisch J, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac

SM, Janesko-Feldman K, Okonkwo DO, Kochanek PM. Sulfonylurea receptor 1 is a potential biomarker

for cerebral edema in traumatic brain injury. Critical Care Medicine, in press.

Jha RM, Puccio A, Okonkwo DO, Zusman BE, Park S-Y, Wallisch J, Empey PE, Shutter LA, Clark RSB,

Kochanek PM, Conley YP. ABCC8 Single nucleotide polymorphisms are associated with cerebral edema

in severe TBI. Neurocritical Care, in press.

Lori Shutter, MD, Professor

Jackson J, Wilmarth M, Shutter L. Update of Clinical Practice Guidelines for Brain Death Determination

in an Academic Heath Center. J Neurosci Nurs 2015;47:44-50. doi: 10.1097/JNN.0000000000000110.

PMID: 25565594

Muehlschlegel S, Shutter L, Col N, Goldberg R. Decision Aids and Shared Decision-Making in

Neurocritical Care: An Unmet Need in Our NeuroICUs. Neurocrit Care. 2015 Jan 6. [Epub ahead of print]

Mirzaalian, H, Ning L, Savadjiev P, Pasternak O, Bouix S, Michailovich O, Grant G, Marx CE, Morey

RA, Flashman LA, George MS, McAllister TW, Andaluz N, Shutter L, Coimbra R, Zafonte RD, Coleman

MJ, Kubicki M, Westin CF, Stein MB, Shenton ME, Rathi Y. Inter-site and inter-scanner diffusion MRI

data harmonization. NeuroImage 2016; 135:311–323. doi: 10.1016/j.neuroimage.2016.04.041. Epub 2016

Apr 30. PMID: 27138209.

186

Elmer J, Gianakas JJ, Rittenberger JC, Baldwin ME, Faro J, Plummer C, Shutter LA, Wassel CL,

Callaway CW, Fabio A; Pittsburgh Post-Cardiac Arrest Service. Group-Based Trajectory Modeling of

Suppression Ratio After Cardiac Arrest. Neurocrit Care 2016;25:415-423. PMID: 27033709

Dreier J, Fabricius, M, Ayata, C, Sakowitz, O, et al. Recording, analysis, and interpretation of spreading

depolarizations in neurointensive care: review and recommendations of the COSBID research group. J

Cereb Blood Flow Metab. 2016 Jun 17. pii: 0271678X16654496. doi: 10.1177/0271678X16654496.

[Epub ahead of print] PMID: 27317657

Coppler PJ, Marill KA, Okonkwo DO, Shutter LA, Dezfulian C, Rittenberger JC, Callaway CW, Elmer

J. Concordance of Brain and Core Temperature in Comatose Patients After Cardiac Arrest. Ther

Hypothermia Temp Manag 2016;6:194-197. [Epub 2016 Jun 1]. PMID: 27249337

Jha RM, Puccio AM, Okonkwo DO, Zusman BE, Park SY, Wallisch J, Empey PE, Shutter LA, Clark

RS, Kochanek PM, Conley YP. ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral

Edema in Severe TBI. Neurocrit Care 2017;26(2):213-224. doi: 10.1007/s12028-016-0309-z [Epub 2016

Sep 27]. PMID: 27677908

Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA,

Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Sulfonylurea Receptor-1: A Novel

Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Crit Care Med 2017;45(3):e255-e264.

doi: 10.1097/CCM.0000000000002079 [Epub 2016 Nov 14]. PMID: 27845954

Mirzaalian H, Ning L, Savadjiev P, Pasternak O, Bouix S, Michailovich O, Karmacharya S, Grant G,

Marx CE, Morey RA, Flashman LA, George MS, McAllister TW, Andaluz N, Shutter L, Coimbra R,

Zafonte RD, Coleman MJ, Kubicki M, Westin CF, Stein MB, Shenton ME, Rathi Y. Multi-site

harmonization of diffusion MRI data in a registration framework. Brain Imaging Behav. 2017 Feb 7. doi:

10.1007/s11682-016-9670-y. [Epub ahead of print] PMID: 28176263

Neuroimmunology Division

Zongqi Xia, MD, PhD

Liao K, Cai T, Savova G, Murphy S, Karlson E, Ananthakrishnan A, Gainer S, Shaw S, Xia Z, Szolovits

P, Churchill S, and Kohane I (2015). Development of phenotype algorithms using electronic medical

records and incorporating natural language processing. BMJ. 350: h1885. PMCID: PMC4707569.

Liao K, Ananthakrishnan A, Kumar V, Xia Z, Cagan A, Gainer V, Goryachev S, Chen P, SavovaG,

Agiel D, Churchill S, Lee J, Murphy S, Plenge, R, Szolovits P, Kohane I, Shaw S, Karlson E and Cai T

(2015). Methods to develop an electronic medical record phenotype algorithm to compare the risk of

coronary artery disease across 3 chronic disease cohorts. PLoS One. 10(8):e0136651. PMCID:

PMC4547801.

Xia Z, White C, Owen E, von Korff A, Clarkson S, McCabe C, Cimpean M, Winn P, Hoesing A, Steele

S, Cortese I, Chitnis T, Weiner H, Reich D, Chibnik L and De Jager P (2015). Genes and Environment

in Multiple Sclerosis (GEMS) Project: a platform to investigate multiple sclerosis risk. Annals of Neurology. 79: 178-89. PMCID: PMC4778957.

Bove R, Musallam A, Xia Z, Baruch N, Messina S, Healy B and Chitnis T (2016). Longitudinal BMI

trajectories in multiple sclerosis: sex differences in association with disease severity. Multiple Sclerosis and Related Disorders. ePublished.

Bove R, Chua A, Xia Z, Chibnik L, De Jager P and Chitnis T (2016). Complex relation of HLA

DRB1*1501, age at menarche and age at multiple sclerosis onset. Neurology Genetics. 2: e88. PMCID:

PMC4962522.

187

Bargiela D, Bianchi M, Westover B, Chibnik L, Healy B, De Jager P and Xia Z (2017). Selection of

first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 88: 677-684.

PMCID: PMC5317380.

Xia Z, Steele S, Bakshi A, Clarkson S, White C, Schindler M, Dewey B, Price L, Nair G, Ohayon J,

Chibnik L, Cortese I, De Jager P and Reich D (2017). Assessment of early evidence of multiple sclerosis

in a prospective study of asymptomatic high-risk first-degree family members. JAMA Neurology. 74:

293-300. PMCID: PMC5348267.

Xia Z and Friedlander R (2017). Minocycline in multiple sclerosis: compelling results but too early to

tell. N Engl J Med. 376: 2191-2193.

Neuromuscular Diseases Division

David Lacomis, MD, Professor and Chief, Neuromuscular Diseases

Avila D, Lacomis D. Neuromuscular Pathology Case. J Clin Neuromusc Dis 2015;17:30-33.

PMID:2630137.

El-Dokla A, Lacomis D. Histopathologic Findings in Five Patients with Hypomyopathic

Dermatomyositis: The importance of MHC 1 expression on myofibers. J Clin Neuromusc Dis 2015;

17:52-58 PMID:26583490.

Juranek JK, Daffu GK, Wojkiewiz J, Lacomis D, Kofler J, Schmidt AA. Receptor for advanced glycation

end products and its inflammatory ligands are upregulated in amyotrophic lateral sclerosis. Front Cell Neurosci, 22 December 2015 http://dx.doi.org/10.3389/fncel.2015.00485.

Shefner JM, Wolff AA, Meng L, Bian A, Lee J, Barragan D, Andrews JA & On behalf of the Benefit-

ALS study group: A randomized, placebo-controlled, double –blind phase IIB trial evaluating the safety

and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis, Amyotroph Lateral Scler

Frontotemporal Degener. 2016;1-10 PMID:26982815.

Avila JD, Lacomis D, Lam E. Neuralgic Amyothophy Associated with hepatitis E virus infection: First

case in the United States: J Clin Neuromusc Dis, in press.

Galdys A, Kale H, Lacomis D, Vergidis P, Murdoch G. Progressive right-sided hemiparesis in a man

with sarcoidosis. Clin Infect Dis 2016;9:1186-1187 PMID:27060792.

Avila JD, Lacomis D. Proximal limb weakness in a patient with celeiac disease; Copper deficiency, gluten

sensitivity or both underlying cause? Case Reports in Neurological Medicine 2016;54:1594-9. PMIC

27994896.

Gendrom TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity

LM, Jansen-West K, Perkerson EA, O’Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian

LJ, Lee CW, ue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW,

Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A,

Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN,

McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A,

Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitchevea D, Antognetti G,

McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski

188

JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD,

Floeter MK, Rothstein JD, Boylan KB, Petrucelli L. Poly(GP) proteins are a useful pharmacodynamic

marker for C90RF72-associated amyotrophic lateral sclerosis. Sci Transl Med. 2017 Mar 29:9(383).

Pii:eaai7866. Doi;10.1126/scitranslmed.aai7866.MPIC 28356511.

Araya Puwananat, MD, Assistant Professor

Heatwole C, Bode R, Johnson N, Dekdebrun J, Dilek N, Eichinger K, Hilbert JE, Logigian E, Luebbe E,

Martens W, McDermott, MP, Pandya S, Puwanant A, Rothrock N, Thornton C, Vickrey BG, Victorson

D, Moxley RT. The myotonic dystrophy health index: Correlations with clinical tests and patient function.

Muscle Nerve 2015; June 4. doi:10.1002/mus.24725. [Epub ahead of print]. PMID 26044513.

Saša Živković, MD, PhD Associate Professor

Silvestri NJ, Zivkovic S, Wolfe GI, Lacomis D. What’s in the Literature: Journal of Clinical

Neuromuscular Disease. 2015 Mar; 16 (3)170-9. PMID: 25695923. Doi:

10.1097/CND.0000000000000073.

Zivokic S, Intravenous immunoglobulin in the treatment of neurologic disorders. Acta Neurologica Scandinavica. 2015 May 21. PMID: 25997034. Doi: 10.1111/ane.12444.

Avila JD, Živkovic S. The neurology of solid organ transplantation. Current Neurology and Neuroscience

Reports. 2015 Jul; 15 (7):560. PMID: 26008808. doi: 10.1007/s11910-015-0560-2.

Felicetti P, Trotta F, Bonetto C, Santuccio C, Pernus YB, Burgner D, Chandler R, Girolomoni G, Hadden

RD, Kochar S, Kukucu M, Monaco G, Ozen S, Pahud B, Phuong L, Bachtiar NS, Teeba A, Top K,

Varricchio F, Wise RP, Zanoni G, Živkovic S, Bonhoeffer J, Brighton Collaboration Vasculitis Working

Group. Spontaneous reports of vasculitis as an adverse event following immunization: A descriptive

analysis across three international databases. Vaccine. 2015 Sep 18. PMID: 26392009. doi:

10.1016/j.vaccine.2015.09.027.

Bonetto C, Trotta F, Felicetti P, Santuccio C, Bachtiar NS, Pernus YB, Chandler R, Girolomoni G, Hadden

RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živkovic S, Bonhoeffer J,

Brighton Collaboration Vasculitis Working Group. Vasculitis as an adverse event following immunization

- Systematic literature review. Vaccine. 2015 Sep 19. PMID: 26398442. doi:

10.1016/j.vaccine.2015.09.026.

Avila JD, Živkovic S. Spinal epidural abscess following treatment with rituximab. Acta Neurologica

Scandinavica. 2015 Sep 22. PMID: 26392320. doi: 10.1111/ane.12506.

Hadden RD, Collins MP, Živkovic SA, Hsieh ST, Bonetto C, Felicetti P, Marchione P, Santuccio C,

Bonhoeffer J, Brighton Collaboration Vasculitic Peripheral Neuropathy Working Group. Vasculitic

peripheral neuropathy: Case definition and guidelines for collection, analysis, and presentation of

immunisation safety data. Vaccine. 2015 Dec 2. PMID: 26655629. doi: 10.1016/j.vaccine.2015.11.047.

Lange-Maia BS, Newman AB, Cauley JA, Boudreau RM, Jakicic JM, Caserotti P, Glynn NW, Harris TB,

Kritchevsky SB, Schwartz AV, Satterfield S, Simonsick EM, Vinik AI, Zivkovic S, Strotmeyer ES, Health,

Aging and Body Composition Study. Sensorimotor Peripheral Nerve Function and the Longitudinal

Relationship With Endurance Walking in the Health, Aging and Body Composition Study.

Archives of Physical Medicine and Rehabilitation. 2016 Jan; 97 (1):45-52. PMCID: PMC4696894. PMID:

26343170. doi: 10.1016/j.apmr.2015.08.423.

189

Lange-Maia BS, Cauley JA, Newman AB, Boudreau RM, Jakicic JM, Glynn NW, Zivkovic S, Dam T,

Caserotti P, Cawthon PM, Orwoll ES, Strotmeyer ES. Sensorimotor Peripheral Nerve Function and

Physical Activity in Older Men. Journal of Aging and Physical Activity. 2016 Mar 11. PMID: 26964668.

doi:10.1123/japa.2015-0207.

Hersh AO, Alarcón GS, Bonetto C, Pernus YB, Kucuku M, Santuccio C, Živković S, Bonhoeffer J;

Brighton Collaboration Systemic Lupus Erythematosus Working Group.Systemic Lupus Erythematosus:

Case definition and guidelines for data collection,analysis, and presentation of immunization safety data.

Vaccine. 2016 Dec 12;34(51):6572-81. doi: 10.1016/j.vaccine.2016.09.031. PubMed PMID: 27816371.

Mnatsakanova D, Živković S. Iatrogenic amyloid polyneuropathy after domino liver transplantation. World J Hepatol. 2017 Jan 28; 9(3):126-30. doi:10.4254 /wjh.v9.i3.126. PubMed PMID: 28217248.

Gonzalez N, Puwanant A, Lu A, Marks S, Živković SA. Myasthenia triggered by immune checkpoint

inhibitors: new case and literature review. 2017 Mar; 27 (3):266-8. doi: 10.1016/j.nmd.2017.01.002.

PubMed PMID: 28109638.

Jacobs BC, van den Berg N, Verboon C, Chavada G, Cornblath DR, Gorson KC, Harbo T, Hartung HP,

Hughes RA, Kusunoki S, van Doorn, PA, Willison HJ, IGOS Consortium. International Guillain-Barré

Syndrome Outcome Study (IGOS):Protocol of a prospective observational cohort study on clinical and

biological predictors of disease course and outcome in Guillain-Barré. J Periph Nerv Syst.

doi:10.1111/jms.12209. PMID: 28406555.

Lange-Maia BS, Newman AB, Jakicic JM, Cauley JA, Boudreau RM, Schwartz AV, Simonsick EM,

Satterfield S, Vinik AI, Zivkovic S, Harris TB, Strotmeyer ES. Relationship between sensorimotor

peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the

Health, Aging and Body Composition Study. Exp Gerontol. 2017 Apr 22. pii: S0531-5565(16)30201-7.

doi:10.1016/j.exger.2017.04.007. [Epub ahead of print] PubMed PMID.

Neurooncology Program

Jan Drappatz, MD, Associate Professor

Kaley TJ, Wen P, Schiff D, Ligon K, Haidar S, Karimi S, Lassman AB, Nolan CP, DeAngelis LM,

Gavrilovic I, Norden A, Drappatz J, Lee EQ, Purow B, Plotkin SR, Batchelor T, Abrey LE, Omuro A.

Phase II trial of sunitinib for recurrent and progressive atypical and anaplastic meningioma. Neuro Oncol.

2015 Jan;17(1):116-21. Epub 2014 Aug 6. PMID: 25100872.

Lee EQ, Reardon DA, Schiff D, Drappatz J, Muzikansky A, Grimm SA, Norden AD, Nayak L,

Beroukhim R, Rinne ML, Chi AS, Batchelor TT, Hempfling K, McCluskey C, Smith KH, Gaffey SC,

Wrigley B, Ligon KL, Raizer JJ, Wen PY. Phase II study of panobinostat in combination with

bevacizumab for recurrent glioblastoma and anaplastic glioma. Neuro Oncol. 2015 Jan 7. pii: nou350.

[Epub ahead of print]. PMID: 25572329.

Norden AD, Ligon KL, Hammond SN, Muzikansky A, Reardon DA, Kaley TJ, Batchelor TT, Plotkin SR,

Raizer JJ, Wong ET, Drappatz J, Lesser GJ, Haidar S, Beroukhim R, Lee EQ, Doherty L, Lafrankie D,

Gaffey SC, Gerard M, Smith KH, McCluskey C, Phuphanich S, Wen PY. Phase II study of monthly

pasireotide LAR (SOM230C) for recurrent or progressive meningioma. Neurology. 2015 Jan

20;84(3):280-6. Epub 2014 Dec 19. PMID: 25527270. PMCID: 4335993.

190

Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden

AD, Gerstner ER, Betensky RA, Batchelor TT. Vandetanib plus sirolimus in adults with recurrent

glioblastoma: results of a phase I and dose expansion cohort study. J Neurooncol. 2015 Feb;121(3):627-

34. Epub 2014 Dec 13. PMID: 25503302. PMCID: 4324090.

Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow B, Muzikansky A,

Ancukiewicz M, Huse JT, Ramkissoon SH, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander

BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor T, Ligon KL, Wen PY. A multicenter,

phase II, randomized, non-comparative clinical trial of radiation and temozolomide with or without

vandetanib in newly-diagnosed glioblastoma patients. Clin Cancer Res. 2015 Apr 24. pii:

clincanres.3220.2014. [Epub ahead of print]. PMID: 25910950.

Lee EQ, Reardon DA, Schiff D, Drappatz J, Muzikansky A, Grimm SA, Norden AD, Nayak L,

Beroukhim R, Rinne ML, Chi AS, Batchelor TT, Hempfling K, McCluskey C, Smith KH, Gaffey SC,

Wrigley B, Ligon KL, Raizer JJ, Wen PY. Phase II study of panobinostat in combination with

bevacizumab for recurrent glioblastoma and anaplastic glioma. Neuro Oncol. 2015 Jun;17(6):862-7. Epub

2015 Jan 7. PMID: 25572329.

Nikiforova MN, Wald AI, Melan MA, Roy S, Zhong S, Hamilton RL, Lieberman FS, Drappatz J,

Amankulor NM, Pollack IF, Nikiforov YE, Horbinski C. Targeted next-generation sequencing panel

(GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol. 2015

Dec 17. pii: nov289. [Epub ahead of print]. PMID: 26681766.

McDowell MM, Zhu X, Agarwal N, Nikiforova MN, Lieberman FS, Drappatz J. Response of relapsed

central nervous system hairy cell leukemia to vemurafenib. Leuk Lymphoma. 2016 Apr 27:1-3. [Epub

ahead of print] No abstract available. PMID: 27116997.

Lee EQ, Muzikansky A, Drappatz J, Kesari S, Wong ET, Fadul CE, Reardon DA, Norden AD, Nayak

L, Rinne ML, Alexander BM, Arvold ND, Doherty L, Stefanik J, LaFrankie D, Ruland SF, Pulverenti J,

Smith KH, Gaffey SC, Hammond S, Wen PY. A randomized, placebo-controlled pilot trial of armodafinil

for fatigue in patients with gliomas undergoing radiotherapy. Neuro Oncol. 2016 Jun;18(6):849-54. doi:

10.1093/neuonc/now007. Epub 2016 Feb 21. PMID: 26902850.

Boele FW, Given CW, Given BA, Donovan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS,

Sherwood PR. Family caregivers' level of mastery predicts survival of patients with glioblastoma: A

preliminary report. Cancer. 2016 Oct 27. [Epub ahead of print] PMID: 27787881.

Lieberman, MD, Professor

Robins HI, Zhang P, Gilbert MR, Chakravarti A, de Groot JF, Grimm SA, Wang F, Lieberman FS,

Krauze A, Trotti AM, Mohile N, Kee AY, Colman H, Cavaliere R, Kesari S, Chmura SJ, Mehta M. A

randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide

resistant glioblastoma: an NRG oncology RTOG group study. J Neurooncol. 2016 Jan;126(2):309-16.

Epub 2015 Oct 27. PMID: 26508094.

Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, Taylor LP, Lieberman F, Silvani

A, Fink KL, Barnett GH, Zhu JJ, Henson JW, Engelhard HH, Chen TC, Tran DD, Sroubek J, Tran ND,

Hottinger AF, Landolfi J, Desai R, Caroli M, Kew Y, Honnorat J, Idbaih A, Kirson ED, Weinberg U, Palti

Y, Hegi ME, Ram Z. Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs

Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. JAMA. 2015 Dec 15;314(23):2535-

43. PMID: 26670971.

191

Nikiforova MN, Wald AI, Melan MA, Roy S, Zhong S, Hamilton RL, Lieberman FS, Drappatz J,

Amankulor NM, Pollack IF, Nikiforov YE, Horbinski C. Targeted next-generation sequencing panel

(GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol. 2016

Mar;18(3):379-87. Epub 2015 Dec 17. PMID: 26681766.

McDowell MM, Zhu X, Agarwal N, Nikiforova MN, Lieberman FS, Drappatz J. Response of relapsed

central nervous system hairy cell leukemia to vemurafenib. Leuk Lymphoma. 2016 Apr 27:1-3. [Epub

ahead of print] No abstract available. PMID: 27116997.

Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM,

Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C,

Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen MC, Van Meir EG, Osuka S,

Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Nageswara Rao

AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S,

Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM,

Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M,

Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach

A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T,

Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG,

Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F,

Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U,

Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR,

Armstrong TS, Korshunov A, Ellison DW, Taylor MD. Therapeutic Impact of Cytoreductive Surgery and

Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

J Clin Oncol. 2016 Jun 6. pii: JCO657825. [Epub ahead of print] PMID: 27269943.

Yankeelov TE, Mankoff DA, Schwartz LH, Lieberman FS, Buatti JM, Mountz JM, Erickson BJ, Fennessy

FM, Haung W, Kalpathy-Cramer J, Wahl RL, Linden HM, Kinahan PE, Zhao B, Hylton NM, Gillies RJ,

Clarke L, Nordstom R, Rubin DL. Quantitative Imaging in Cancer Clinical Trials. Clin Cancer Res. 2016

Jan 15;22(2):284-90. Review. PMID: 26773162.

Lodge MA, Holdhoff M, Leal JP, Bag AK, Nabors LB, Mintz A, Lesser GJ, Mankoff DA, Desai AS,

Mountz JM, Lieberman FS, fisher JD, Desideri S, Ye X, Grossman SA, Schiff D, Wahl RL. Repatability

of 18F-FLT-PET in a Multi-Center Study of Patients with High Grade Glioma. J Nuci Med. 2016 Sep 29.

Pii: jnumed.116.178434. [Epub ahead of print] PMID: 276688473.

Boele FW, Given CW, Given BA, Donavan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS,

Sherwood PR. Family caregivers’ level of mastery predicts survival of patients with glioblastoma:A

preliminary report. Cancer. 2016 Oct 27. [Epub ahead of print] PMID: 27787881.

Research Division

Franca Cambi, MD, PhD, Professor

Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz

K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ,

Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey

RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo

192

ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS,

Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills

AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a

randomized clinical trial. JAMA. 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120.

GM1 ganglioside in Parkinson’sdisease: Pilot study of effects on dopamine transporter binding. Schneider

JS, Cambi F, Gollomp SM, Kuwabara H, Brašić JR, Leiby B, Sendek S, Wong DF. J Neurol Sci. 2015

Sep 15;356(1-2):118-23. doi: 10.1016/j.jns.2015.06.028. Epub 2015 Jun 16.

Pioglitazone in early Parkinson’s disease: a phase 2, multicentre, double-blind, randomised trial. NINDS

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by comprehensive multi-system integrative analyses. Kapeli K, Pratt G, Vu A, Martinez F, Freese P,

Lambert NJ, Hutt K, Sundaraman B, Huelga SC, Chun S, Liang S, Cheang J, Donohue JP, Shiue L, Zhu

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Leehey, MD; Sheng Luo, PhD; Saloni Sharma, MBBS; Anne-Marie A Wills, MD, MPH; Jacquelyn L

Bainbridge, BSPharm, PharmD, FCCP; Pei Shieen Wong, PharmD, BCPS; David K Simon, MD, PhD;

Jay Schneider, PhD; Yunxi Zhang, MS; Adriana Pérez, MS, PhD; Rohit Dhall, MD, MSPH; Chadwick W

Christine, MD; Carlos Singer, MD; Franca Cambi, MD, PhD; James T Boyd, MD. Revised manuscript

submitted to Neurology 2017.

Guodong Cao, PhD, Associate Professor

Leak RK, Li P, Zhang F, Sulaiman HH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y, Chen J.

Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects

Hippocampal Neurons from Ischemic Injury. Antioxid Redox Signal. 2015, (22):135-148.

Wang Z, Cheng Y, Ye L, Xia Q, Johnson NR, Chen D, Wei X, Cao G, Fu X, Li X, Zhang H, Xiao J.

bFGF protects against Blood-Brain Barrier damage through junction protein regulationvia P13K-Akt-

Rac1 pathway following traumatic brain injury. Mol Neurobiol. 2015 Dec 21. [Epub ahead of print].

Chen X, Zhao S, Song Y, Shi Y, Leak RK, Cao G. The Role of Nicotinamide phosphoribosyltransferase

in Cerebral Ischemia. Current Topics in Medicinal Chemistry. 2015;15(21):2211-21.

Lin L, Zhang H, Yang J, Wang Z, Lin R, Wu J, Li Z, Cao G, Chen L, Ye J, He S, Wei X, Gan C, Li X,

Xiao J. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of bFGF in 6-

OHDA-induce Parkinson’s disease model. Int J Bio Sci. 2016, 7(5).

Zhou Y, Zhang H, Zheng B, Ye L, Zhu S, Johnson NR, Wang Z, Wei X, Chen D, Cao G, Fu Xi, Li X,

Xu H, Xiao J. Retinoic acid induced-autophagic flux inhibits ER-stress dependent apoptosis and prevents

disruption of blood-spinal cord barrier after spinal cord injury. International Journal of Biological

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Wang Y, Liu G, Hong H, Chen F, Ji X, Cao G. White Matter Injury in Ischemic Stroke. Progress in

Neurobiology. 2016 Jun;141:45-60. Pii: S0301-0082(16)30001-6. Doi: 10.1016.

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Homanics GE,

Cao G, Bennetta MVL, Chen J. APE1/ref1 facilitates recovery of gray and white matter and neurological

function after mild stroke injury. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67.

Wang Y, Ji X, Cao G. Stem cell therapy in ageing CNS diseases. Ageing Research Reviews. In Press.

Jun Chen, MD, Professor of Neurology

Wang H, Shi H, Yu Q, Chen J, Zhang F, Gao Y. Sevoflurane Preconditioning Confers Neuroprotection

via Anti-apoptosis Effects. Acta neurochirurgica. Supplement. 2016; 121:55-61.

Sun BL, He MQ, Han XY, Sun JY, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,

Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal Delivery of Granulocyte Colony-

Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats. Molecular

neurobiology. 2016; 53(1):320-330.

Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji

X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and

long-term ischaemic reperfusion brain injury. Nature communications. 2016; 7:10523.

Liu X, Liu J, Zhao S, Zhang H, Cai W, Cai M, Ji X, Leak RK, Gao Y, Chen J, Hu X. Interleukin-4 Is

Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia.

Stroke. 2016; 47(2):498-504.

Shi Y, Leak RK, Keep RF, Chen J. Translational Stroke Research on Blood-Brain Barrier Damage:

Challenges, Perspectives, and Goals. Translational stroke research. 2016; 7(2):89-92.

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,

Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref-1 facilitates recovery of gray and white matter

and neurological function after mild stroke injury. Proceedings of the National Academy of Sciences of

the United States of America. 2016; 113(25):E3558-67.

Zhang W, Zhang H, Mu H, Zhu W, Jiang X, Hu X, Shi Y, Leak RK, Dong Q, Chen J, Gao Y. Omega-3

polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury.

Neurobiology of disease. 2016; 91:37-46.

Wu Y, Wang J, Shi Y, Pu H, Leak RK, Liou AK, Badylak SF, Liu Z, Zhang J, Chen J, Chen L.

Implantation of Brain-derived Extracellular Matrix Enhances Neurological Recovery after Traumatic

Brain Injury. Cell transplantation. 2016

Li PY, Wang X, Stetler RA, Chen J, Yu WF. Anti-inflammatory signaling: the point of convergence for

medical gases in neuroprotection against ischemic stroke. Medical gas research. 2016

Pu H, Jiang X, Hu X, Xia J, Hong D, Zhang W, Gao Y, Chen J, Shi Y. Delayed Docosahexaenoic Acid

Treatment Combined with Dietary Supplementation of Omega-3 Fatty Acids Promotes Long-Term

Neurovascular Restoration After Ischemic Stroke. Translational stroke research. 2016; 7(6):521-534.

194

Jiang X, Pu H, Hu X, Wei Z, Hong D, Zhang W, Gao Y, Chen J, Shi Y. A Post-stroke Therapeutic

Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial

Microglial Responses after Cerebral Ischemia. Translational stroke research. 2016; 7(6):548-561.

Hu X, De Silva TM, Chen J, Faraci FM. Cerebral Vascular Disease and Neurovascular Injury in Ischemic

Stroke. Circulation research. 2017; 120(3):449-471.

Shi Y, Jiang X, Zhang L, Pu H, Hu X, Zhang W, Cai W, Gao Y, Leak RK, Keep RF, Bennett MV, Chen

J. Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier

disruption after ischemic brain injury. Proceedings of the National Academy of Sciences of the United

States of America. 2017; 114(7):E1243-E1252.

Cai W, Zhang K, Li P, Zhu L, Xu J, Yang B, Hu X, Lu Z, Chen J. Dysfunction of theneurovascular unit

in ischemic stroke and neurodegenerative diseases: An aging effect. Ageing research reviews. 2017;

34:77-87.

Cai W, Liu H, Zhao J, Chen LY, Chen J, Lu Z, Hu X. Pericytes in Brain Injury and Repair After Ischemic

Stroke. Translational stroke research. 2017; 8(2):107-121.

Pu H, Jiang X, Wei Z, Hong D, Hassan S, Zhang W, Liu J, Meng H, Shi Y, Chen L, Chen J. Repetitive

and Prolonged Omega-3 Fatty Acid Treatment After Traumatic Brain Injury Enhances Long-Term Tissue

Restoration and Cognitive Recovery. Cell transplantation. 2017; 26(4):555-569.

Zhang W, Chen R, Yang T, Xu N, Chen J, Gao Y, Stetler RA. Fatty acid transporting proteins: Roles in

brain development, aging, and stroke. Prostaglandins, leukotrienes, and essential fatty acids. 2017

Yang Y, Liu H, Zhang H, Ye Q, Wang J, Yang B, Mao L, Zhu W, Leak RK, Xiao B, Lu B, Chen J, Hu

X. ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury. The Journal of

neuroscience. 2017; 37(18):4692-4704.

Zhang J, Pu H, Zhang H, Wei Z, Jiang X, Xu M, Zhang L, Zhang W, Liu J, Meng H, Stetler RA, Sun D,

Chen J, Gao Y, Chen L. Inhibition of Na+-K+-2Cl- cotransporter attenuates blood-brain-barrier

disruption in a mouse model of traumatic brain injury. Neurochemistry international. 2017

Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen

G, Hu X. Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after

stroke. Brain. 2017; 140(7):1914-1931.

Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan SH, Stetler RA, Chen J, Yin KJ. MicroRNA-15a/16-1

Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke. Stroke. 2017; 48(7):1941-1947.

Paula Clemens, MD, Professor and Chief of Service, VAMC

Spurney C, Shimizu R, Hache, LP, Kolski H, Gordish-Dressman H, Clemens PR and the CINRG

Investigators. CINRG Duchenne natural history study demonstrates insufficient diagnosis and treatment

of cardiomyopathy in Duchenne muscular dystrophy. Muscle Nerve 2014 Aug; 50(2):250-6. PMID:

24395289. PMCID: PMC4081523 (Available 7/3/2015).

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Spurney CF, McCaffrey FM, Cnaan A, Morgenroth LP, Ghelani SJ, Gordish-Dressman H, Arrieta A,

Connolly AM, Lotze T, McDonald C, Leshner R and Clemens PR. Feasibility and reproducibility of

echocardiographic measures in children with muscular dystrophies. Journal of the American Society of Echocardiography 2015 Apr; epub ahead of print PMID:25906753.

Reay DP, Bastacky SI, Wack KE, Stolz DB, Robbins PD, Clemens PR. D-amino acid substitution

of peptide-mediated NF-B suppression in mdx mice preserves therapeutic benefit in skeletal muscle,

but causes kidney toxicity. Molecular Medicine, 2015 May; 21:442-452. PMID: 26018805.

Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L,

Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, Sweeney HL, Williams S, Gold L.

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy. Proceedings of the

National Academy of Sciences, 2015 Jun; 112(23):153-8. PMID: 26039989. PMCID: PMC4466703.

Chung J, Smith AL, Hughes SC, Niizawa G, Abdel-Hamid HZ, Naylor EW, Hughes T and Clemens

PR. Twenty-year follow-up of newborn screening for patients with muscular dystrophy. Muscle

Nerve, 2016 Apr; 53:570-578. PMID: 26260293

Boca SM, Nishida M, Harris M, Rao S, Cheema2 AK, Gill K, Seol H, Morgenroth LP, Henricson E,

McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S. Discovery of metabolic

biomarkers for Duchenne muscular dystrophy within a natural history study. PLOS ONE, 2016 Apr

15; 11(4):e0159895; http://dx.doi.org/10.1371/journal.pone.0153461. PMID: 27082433

Hathout Y, Conklin L, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier

CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, May JK, McDonald C, Hoffman

EP. Serum pharmacodynamics biomarkers for chronic corticosteroid treatment of children. Scientific

Reports, 2016 Aug 17; 6:31727; DOI:10.1038/srep31727.

Hilbert JE, Barohn RJ, Clemens PR, Luebbe EA, Martens WB, McDermott MP, Parkhill AL, Tawil

R, Thornton CA, Moxley III RT. High frequency of gastrointestinal manifestations in myotonic

dystrophy type 1 and type 2. Neurology, 2017, in press.

Steven Graham, MD, PhD, Professor and Vice Chair for Research and Chief, Research Division

Liu H, Chen J, Li W, Rose ME, Shinde SN, Balasubramani M, Uechi GT, Mutus B, Graham SH, Hickey

RW. Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for

hypoxic ischemic injury. FEBS J 82: 2045–2059, 2015.

Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock

BD, Poloyac SM. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-

cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke. Am J Physiol Heart

Circ Physiol 305: H1605-13, 2013. PMCID: 3882464

Shaik JS, Miller TM, Graham SH, Manole MD, Poloyac SM. Rapid and simultaneous quantitation

of prostanoids by UPLC-MS/MS in rat brain. J Chromatogr B Analyt Technol Biomed Life Sci 945-

946C: 207-216, 2013. PMCID: 4134920

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Liu H, Chen J, Li W, Rose ME, Shinde SN, Balasubramani M, Uechi GT, Mutus B, Graham SH,

Hickey RW. Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins:

implications for hypoxic ischemic injury. FEBS J 82: 2045–2059, 2015. PMCID: 4972022

Eric Hoffman, PhD, Research Assistant Professor

Di Maio R, Barrett PJ, Hoffman EK, Barrett C, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton

EA, Hastings TG, Greenamyre JT. α-Synuclein binds TOM20 and inhibits mitochondrial protein import

in Parkinson’s disease. Sci Transl Med. Jun 8;8(342):342ra78. 2016.

Xiaoming Hu, MD, MS, PhD, Research Assistant Professor

Zhang W, Liu J, Hu X, Li P, Leak RK, Gao Y, Chen J. N-3 polyunsaturated fatty acids reduce neonatal

hypoxic/ischemic brain injury by promoting phosphatidylserine formation and Akt signaling. Stroke.

2015; 46(10):2943-50. Citation: 5

Han L, Cai W, Mao L, Liu J, Li P, Leak RK, Xu Y, Hu X, Chen J. Rosiglitazone promotes white matter

integrity and long-term functional recovery after focal cerebral ischemia. Stroke. 2015; 46(9):2628-36.

Citation: 13

Liesz A, Hu X, Kleinschnitz C, Offner H. Functional role of regulatory lymphocytes in stroke: Facts and

controversies. Stroke. 2015; 46(5):1422-30. Citation: 15

Hu X, Leak RK, Shi Y, Suenaga J, Gao Y, Zheng P, Chen J. Microglia and macrophage polarization-new

prospects for brain repair. Nat Rev Neurol. 2015; 11 (1): 56-64. Citations: 168

Suenaga J, Hu X, Pu H, Shi Y, Hassan SH, Xu M, Leak RK, Stetler RA, Gao Y, Chen J. White matter

injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in

neurological function after stroke. Exp Neurol. 2015, 272:109-19. Citation: 27

Liu ZJ, Chen C, Li FW, Shen JM, Yang Y, Leak RK, Ji X, Du H, Hu X#. Splenic responses in ischemic

stroke: New insights into stroke pathology. CNS Neurosci Ther 2015; 21(4):320-6. (# Corresponding

Author) Citation: 8

Zhang H, Li F, Yang Y, Chen J, Hu X#. SIRP/CD47 signaling in neurological disorders. Brain Res. 2015;

1623:74-80. (# Corresponding Author) Citation: 5

Zhang W, Wang H, Zhang H, Leak RK, Shi Y, Hu X, Gao Y, Chen J. Dietary supplementation with

omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves

neurological functions after stroke. Exp Neurol. 2015; 272:170-80. Citation: 12

Wang G, Shi Y, Jiang X, Leak RK, Hu X, Wu Y, Pu H, Li WW, Tang B, Wang Y, Gao Y, Bennett MVL,

Chen J. Histone deacetylase inhibition prevents white matter injury by modulating microglia/macrophage

polarization through GSK3β/PTEN/Akt axis. Proc Natl Acad Sci U S A. 2015; 112(9):2853-8. Citation: 52

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,

Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref-1 facilitates recovery of gray and white matter and

neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016; 113(25):E3558-67.

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197

Liu ZJ, Chen C, Li XR, Ran YY, Xu T, Zhang Y, Geng XK, Zhang Y, Du HS, Leak RK, Ji XM, Hu X#.

Remote ischemic preconditioning-mediated neuroprotection against stroke is associated with significant

alterations in peripheral immune responses. CNS Neurosci Ther. 2016; 22(1):43-52. (# Corresponding

Author) Citation: 18

Zhang W, Zhang H, Mu H, Zhu W, Jiang X, Hu X, Shi Y, Leak RK, Dong Q, Chen J, Gao Y. Omega-3

polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury.

Neurobiol Dis. 2016; 24;91:37-46. Citation: 6

Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji

X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and

long-term ischaemic reperfusion brain injury. Nat Commun. 2016; 27;7:10523. Citation: 12

Liu X, Liu J, Zhao S, Zhang H, Cai W, Cai M, Ji X. Leak KL, Gao Y, Chen J, Hu X#. Interleukin-4 is

essential for microglia/macrophage M2 polarization and long-term recovery after cerebral ischemia.

Stroke. 2016; 47(2):498-504. (# Corresponding Author) Citation: 12

An C, Jiang X, Pu H, Hong D, Zhang W, Hu X, Gao Y. Severity-dependent long-term spatial learning-

memory impairment in a mouse model of traumatic brain injury. Transl Stroke Res. 2016; 7(6):512-520.

Citation: 2

Jiang X, Pu H, Hu X, Wei Z, Hong D, Zhang W, Gao Y, Chen J, Shi Y. (2016) A post-stroke therapeutic

regimen with omega-3 polyunsaturated fatty acids that promotes white matter integrity and beneficial

microglial responses after cerebral ischemia. Transl Stroke Res. 7(6):548-561.

Pu H, Jiang X, Hu X, Xia J, Hong D, Zhang W, Gao Y, Chen J, Shi Y. Delayed docosahexaenoic acid

treatment combined with dietary supplementation of omega-3 fatty acids promotes long-Term

neurovascular restoration after ischemic stroke. Transl Stroke Res. 2016; 7(6):521-534. Citation: 1

Cai W, Liu H, Zhao J, Chen LY, Chen J, Lu Z, Hu X#. Pericytes in brain injury and repair after ischemic

stroke. Transl Stroke Res. 2017;8(2):107-121. (# Corresponding Author)

Liu H, Yang Y, Xia Y, Zhu W, Leak RK, Wei Z, Wang J, Hu X#. Aging of cerebral white matter. Ageing

Res Rev. 2017; 34:64-76. (# Corresponding Author)

Cai W, Zhang K, Li P, Zhu L, Xu J, Yang B, Hu X, Lu Z, Chen J. Dysfunction of the neurovascular unit

in ischemic stroke and neurodegenerative diseases: An aging effect. Ageing Res Rev. 2017;34:77-87

Shi Y, Jiang X, Zhang L, Pu H, Hu X, Zhang W, Cai W, Gao Y, Leak RK, Keep RF, Bennett MV, Chen

J. Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier

disruption after ischemic brain injury. Proc Natl Acad Sci U S A. 2017;114(7):E1243-E1252.

Hu X, De Silva TM, Chen J, Faraci FM. Cerebral vascular disease and neurovascular injury in ischemic

stroke, Circulation Research. 2017;120(3):449-471.

Yang Y, Liu H, Zhang H, Ye Q, Wang J, Mao L, Zhu W, Xiao B, Lu B, Chen J, Hu X#. ST2/IL-33-

Dependent Microglial Response Limits Acute Ischemic Brain Injury. J Neurosci. 2017 May

3;37(18):4692-4704. (# Corresponding author)

Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen

G, Hu X#. Regulatory T cells ameliorate tissue plasminogen activator-induced brain hemorrhage after

stroke. Brain. 2017 May 22. doi: 10.1093/brain/awx111. (# Corresponding author)

198

Milos Ikonomovic, MD, Associate Professor

Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ (2015)

Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal

Alzheimer’s disease Biol Psych 77(8):693-703.

Pivtoraiko VN, Abrahamson EE, Leurgans SE, DeKosky ST, Mufson EJ, Ikonomovic MD (2015)

Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease. Neurobiol Aging

36(1):12-19.

Scheff SW, Price DA, Ansari MA, Roberts KN, Schmitt FA, Ikonomovic MD, Mufson EJ (2015)

Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease. J Alzheimers

Dis 2015;43:1073-1090.

Curtis C, Gamez JE, Singh U, Sadowsky CH, Villena T, Sabbagh MN, Beach TG, Duara R, Fleisher AS,

Frey KA, Walker Z, Hunjan A, Holmes C, Escovar YM, Vera CX, Agronin ME, Ross J, Bozoki A,

Akinola M, Shi J, Vandenberghe R, Ikonomovic MD, Sherwin PF, Grachev ID, Farrar G, Smith APL,

Buckley CJ, McLain R, Salloway S (2015) Phase 3 trial of flutemetamol labeled with radioactive fluorine

18 imaging and neuritic plaque density. JAMA Neurol 72(3):287-294.

Perez SE, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ (2015) Hippocampal

endosomal, lysosomal and autophagic dysregulation in mild cognitive impairment: correlation with Aβ

and tau pathology. J Neuropathol Exp Neurol 74(4):345-358.

Jackson TC, Bayir H, Ikonomovic MD, Janesko-Feldman K, Mi Z, Gao T, Jackson EK, Kochanek PM

(2015) Detection of PHLPP1α/β in human and mouse brain by different anti-PHLPP1 antibodies. Sci Rep. 5:9377. doi: 10.1038/srep09377. PMID: 25827478

Mufson EJ, Mahady L, Waters D, Counts S, DeKosky ST, Ginsberg SD, Ikonomovic MD, Perez SE,

Scheff S (2015) Hippocampal plasticity during the progression of Alzheimer's disease. Neuroscience 2015

Nov 19;309:51-67.

Marquie M, Normandin MD, Vanderburg CR, Costantino I, Bien EA, Rycyna LG, Klunk WE, Mathis

CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA,

Frosch MP, Hyman BT, Gomez-Isla T (2015) Validating novel tau PET tracer [F-18]-AV-1451 (T807)

on postmortem brain tissue. Ann Neurol 2015 Nov78(5):787-800.

Willyeard FA, Empey PE, Philbrick A, Ikonomovic MD, Puccio AM, Kochanek PM, Okonkwo DO,

Clark RSB (2016) Expression of ATP-binding cassette transporters B1 and C1 after severe traumatic brain

injury in humans. J Neurotrauma 33:226-231.

Kelley CM, Ash JA, Powers BE, Velazquezc R, Alldred MJ, Ikonomovic MD, Ginsberg SD, Strupp BJ,

Mufson EJ (2016) Effects of maternal choline supplementation on the septohippocampal cholinergic

system in the Ts65Dn mouse model of Down syndrome. Curr Alzheimer Res 13:84-96.

Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD (2016) Immunohistochemical analysis

of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.

Neuropathology 36:135-145.

199

Kirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun

M, Kofler JK, Lopez OL, Yates NA, Sweet RA (2016) Altered Levels of Visinin-Like Protein 1

Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 75(2):175-182.

Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic

MD, Lopez OL, Fitz NF, Koldamova R, Yates NA (2016) APOE*4 genotype is associated with altered

levels of glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild

to moderate Alzheimer disease. Mol Cell Proteomics 15(7):2252-2262.

Ikonomovic MD, Abrahamson EE, Price J, Mathis CA, Klunk WE (2016) [F-18]AV-1451 PET retention

in choroid plexus: more than “off-target” binding. Ann Neurology 80(2):307-308.

Mufson EJ, Ikonomovic MD, Counts SE, Perez SE, Malek-Ahmadi M, Scheff SW, Ginsberg SD (2016)

Molecular and cellular pathophysiology of preclinical Alzheimer’s disease. Behav Brain Res 311:54-69.

Mi Z, Halfter W, Abrahamson EE, Klunk WE, Mathis CA, Mufson EJ, Ikonomovic MD (2016).

Tenascin-C is associated with cored amyloid-β plaques in Alzheimer’s disease and pathology burdened

cognitively normal elderly. J Neuropathol Exp Neurol 75(9):868-876.

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford

F, Alvarez V, Stein T, McKee AC (2016) Progression of tau pathology within cholinergic nucleus basalis

neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain

Inj. 30(12):1399-1413.

Ikonomovic MD, Buckley CJ, Heurling K, Sherwin P, Jones PA, Zanette M, Mathis CA, Klunk WE,

Chakrabarty A, Ironside J, Ismail A, Smith C, Thal DR, Beach TG, Farrar G, Smith AP (2016) Post-

mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection. Acta

Neuropathol Commun. 12;4(1):130-155.

Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk

WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S,

DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch

MP, Hyman BT, Johnson KA, Gómez-Isla T (2017) Pathological correlations of [F-18]-AV-1451 imaging

in non-Alzheimer tauopathies. Ann Neurol. 81(1):117-128.

Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA (2017)

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic

mice. Neurobiol Aging. 54:59-70.

Mi Z, Abrahamson EE, Ryu AY, Fish KN, Sweet RA, Mufson EJ, Ikonomovic MD (2017) Loss of

precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early

Alzheimer's disease. Neurobiol Aging. 2017. doi: 10.1016/j.neurobiolaging.2017.01.022. [Epub ahead of

print]

Hao Liu, PhD, Research Assistant Professor

Liu H, Li W, Rose ME, Hickey RW, Chen J, Uechi GT, Balasubramani M, Day B, Patel K, Graham SH.

The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-

induced cytotoxicity: implications for post-ischemic neuronal injury. Cell Death Dis. 2015. 6: e1966;

doi:10.1038/cddis.2015.323

200

Chen Y, Huang XJ, Yu N, Xie Y, Zhang K, Wen F, Liu H, Di Q. HMGB1 Contributes to the Expression

of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced

Glycation End Products. PLoS One. 2015 Oct 20;10(10):e0140918

Liu H, Chen J, Li W, Rose ME, Shinde SN, Balasubramani M, Uechi GT, Mutus B, Graham SH, Hickey

RW. Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for

hypoxic ischemic injury. FEBS J. 2015 May;282(10):2045-59. doi: 10.1111/febs.13259.

Graham SH, Liu H. Life and death in the trash heap: the ubiquitin proteasome pathway and UCHL1 in

brain aging, neurodegenerative disease and cerebral ischemia. Ageing Research Reviews. 2016 Oct 1.

pii: S1568-1637(16)30172-6. doi: 10.1016/j.arr.2016.09.011.

Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH. Rosiglitazone attenuates inflammation and

CA3 neuronal loss following traumatic brain injury in rats. Biochem Biophys Res Commun. 2016 Apr

15;472(4):648-55. doi: 10.1016/j.bbrc.2016.03.003. Epub 2016 Mar 3.

Liu H, Rose ME, Ma X, Culver S, Dixon CE, Graham SH. In vivo transduction of neurons with TAT-

UCH-L1 protects brain against controlled cortical impact injury. PLoS One. 2017 May

24;12(5):e0178049. doi: 10.1371/journal.pone.0178049.

Ruth Stetler, PhD, Research Assistant Professor

Suenaga J, Hu X, Pu H, Shi Y, Hassan SH, Xu M, Leak RK, Stetler RA, Gao Y, Chen J. White matter

injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in

neurological function after stroke. Exp Neurol, 2015;272:109-119.

Leak RK, Li P, Zhang F, Hassan SH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y, Chen J. APE1

upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury.

Antioxidants & Redox Signaling, 2015;22(2);135-148.

Sun BL, He MQ, Han XY, Sun Jy, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,

Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal delivery of granulocyte colony-

stimulating factor enhances its neuroprotective effects against ischemic brain injury in rats. Mol

Neurobiol. 2016;53:320-330.

Shi Y, Zhang L, Pu H, Mao L, Hu X, Jian X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji

X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and

long-term ischaemic reperfusion brain injury. Nat Comm. 2016;7. doi:10.1038/ncomms10523.

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,

Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter

and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567,

doi:10.1073/pnas1606226113.

Sun BL, He MQ, Han XY, Sun Jy, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,

Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal delivery of granulocyte colony-

stimulating factor enhances its neuroprotective effects against ischemic brain injury in rats. Mol

Neurobiol. 2016;53:320-330.

201

Shi Y, Zhang L, Pu H, Mao L, Hu X, Jian X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji

X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and

long-term ischaemic reperfusion brain injury. Nat Comm. 2016;7. doi:10.1038/ncomms10523

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,

Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter

and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567,

doi:10.1073/pnas1606226113.

Li PY, Wang X, Stetler RA, Chen J, Yu WF. Anti-inflammatory signaling: the point of convergence for

medical gases in neuroprotection against ischemic stroke. Med Gas Res. 2016 Dec 30;6(4):227-231.

Zhang W, Chen R, Yang T, Xu N, Chen J, Gao Y, Stetler RA. Fatty acid transporting proteins : Roles

in brain development, aging, and stroke. Prostaglandins, Leukot and Essent Fatty Acids. 2017;

doiI:10.1016/j.plefa.2017.04.004.

Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan S, Stetler RA, Chen J. MicroRNA-15a/16-1 antagomir

ameliorates ischemic brain injury in experimental stroke. Stroke. 2017:in press.

Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen

G, Hu X. Regulatory T cells ameliorate tissue plasminogen activator-induced brain hemorrhage after

stroke. Brain. 2017:in press.

Zhang J, Pu H, Zhang H, Wei Z, Jiang X, Xu M, Zhang L, Zhang W, Liu J, Meng H, Stetler RA, Sun

D, Chen J, Gao Y, Chen L. Inhibition of Na+-K+-2Cl− cotransporter attenuates blood-brain-barrier

disruption in a mouse model of traumatic brain injury. Neurochemistry International. 2017:in press.

Cai M, Zhang W, Weng Z, Stetler RA, Jiang X, Shi Y, Gao Y, Chen J. Promoting neurovascular recovery

in aged mice after ischemic stroke - Prophylactic effect of omega-3 polyunsaturated fatty acids. Aging

Dis. 2017;8(5)531-545. doi: 10.14336/AD.2017.0520

Dandan Sun, MD, PhD, Professor

Roy A, JH. Goodman, G. Begum, BF. Donnelly, G Pittman, EJ. Weinman, Dandan Sun, and AR.

Subramanya. Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. Am J

Physiol Renal Physiol. 308(4):F366-76, 2015

HB Chang, X Gao, R Nepomuceno, S Hu, Dandan Sun. Na+/H+ exchanger in regulation of platelet

activation and paradoxical effects of cariporide. Expt Neurology. 2015, in press, NIHMS661355

Cong D, W. Zhu, J. S. Kuo, S. Hu, and Dandan Sun. Ion transporters in brain tumors. Curr Med Chem;

22(10):1171-81, 2015 PMID: 25620102

K. T. Kahle, A. R. Khanna, S. L. Alper, N. C. Adragna, P. K. Lauf, Dandan Sun and E. Delpire. "K-Cl

cotransporters in nervous system cell volume regulation and disease. Trends in Molecular Medicine, 2015,

in press

202

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Dandan Sun, Hübner CA, Cull-

Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in

perinatal white matter injury. Nat Neurosci. 2015 in press, PMID: 25821912

Begum G, Yuan H, Kahle K, Li L, Wang S, Shi Y, Shmukler BE, Yang S, Lin S, Alper SL, Dandan Sun.

Inhibition of WNK3-SPAK/OSR1 kinase signaling reduces brain damage and accelerates neurological

recovery after stroke. Stroke, 2015, in press, NIHMS 692023

NC. Adragna, NB. Ravilla, PK. Lauf, G Begum, AR. Khanna, Dandan Sun, KT. Kahle. Regulated

phosphorylation of the K-Cl cotransporter KCC3 is a potent switch of intracellular potassium content and

cell volume homeostasis. Frontiers Neuroscience, 9:255, 2015.

LD. Harvey, Y. Yin, IY. Attarwala, G. Begum, J. Deng, HQ. Yan, CE. Dixon, Dandan Sun.

Administration of DHA reduces ER stress-associated inflammation and alters microglial/macrophage

activation in traumatic brain injury. ASN Neuro, 7(6), 2015, PMCID: PMC4710127.

W. Zhu, KE. Carney, VM. Pigott, LM. Falgoust, PA. Clark, JS. Kuo, and Dandan Sun. Glioma-mediated

microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.

Carcinogenesis. 2016 Jun 9. pii: bgw068.

H. Zhao, R. Nepomuceno, X. Gao, LM. Foley, S. Wang, G. Begum, W. Zhu, LM. Falgoust, S. Yang, S-

H. Lin, KT. Kahle, Seth L. Alper, TK. Hitchens, S. Hu, Z. Zhang, and Dandan Sun. Genetic deletion of

the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant

cerebral edema after ischemic stroke. JCBFM. 2016, Feb.,1–14.

Q. Wang, Q. Xu, F. Deng, Z. Xing, Z. WU, B Cen, S. Xu, Z. Zhao, R. Nepomuceno, M. Bhuiyan, Dandan

Sun, J. Wang, A. Ji. Long Non-coding RNA C2dat1 Regulates CaMKIIδ Expression to Promote Neuronal

Survival Through the NF-κB Signaling Pathway. Cell Death & Diseases, 2016, Mar 31;7:e2173.

H. Zhao, KE. Carney, L Falgoust, JW Pan, Dandan Sun, Z. Zhang. Emerging roles of Na+/H+ exchangers

in epilepsy and developmental brain disorders. Progress in Neurobiol. 2016 Mar-May;138-140:19-35.

NIHMSID771733.

F. Boscia, G. Begum, G. Pignataro, R. Sirabella, O. Cuomo, A. Casamassa, Dandan Sun, L. Annunziato.

Glial Na+-dependent ion transporters in pathophysiological conditions. Glia. 2016, 64(10):1677-97. doi:

10.1002/glia.23030.

K. T. Kahle, B. Flores, D. Bharucha-Goebel, J. Zhang, S. Donkervoort, M. Hegde, G. Hussain, B. Liang,

Dandan Sun, C. G. Bönnemann, and E. Delpire. Human peripheral motor neuropathy results from

defective kinase regulation of the KCC3 cotransporter. Science Signaling, 2016, 9(439): ra77. doi:

10.1126/scisignal.aae0546.

Y. Yin, G. Sun, E. Li, K. Kiselyov, Dandan Sun. ER stress and impaired autophagy flux in neuronal

degeneration and brain injury. Ageing Research Reviews 2016, pii: S1568-1637(16)30169-6. doi:

10.1016/j.arr.2016.08.008.

J. Zhang, G. Gao, G. Begum, J. Wang, A. R. Khanna, B. E. Shmukler, G. Daubner, P.Heros, P. Davies, J.

Varghese, M. I. H. Bhuiyan, J.J Duan, J. Zhang, D. Duran, S. L. Alper, Dandan Sun, S. J. Elledge, D. R.

Alessi, K. T. Kahle. Functional kinomics establishes a critical node of volume-sensitive cation-Cl−

cotransporter regulation in the mammalian brain. Scientific Reports, 2016, 6:35986. doi:

10.1038/srep35986.

203

M. I. H Bhuiyan, S. Song, H. Yuan, G. Begum, J. Kofler, K. T Kahle, S-S Yang, S-H Lin, S. L Alper, A.

R Subramanya and Dandan Sun. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic

brain damage in hypertensive rats. JCBFM. 2016, pii: 0271678X16675368. NIHMS 840430.

Y. Yin, E. Li, G. Sun, H. Q. Yan, L. M. Foley, L. A. Andrzejczuk, I. Y. Attarwala, T. K. Hitchens, K.

Kiselyov, C. E. Dixon, Dandan Sun. Effects of DHA on hippocampal autophagy and lysosome function

after traumatic brain injury. Mol Neurobiol. 2017. NIHMS 864940.

Kejie Yin, MD, PhD, Assistant Professor

Yu D, Fan C, Zhang W, Wen Z, Hu L, Yang L, Feng Y, Yin KJ, Mo X. Neuroprotective effect of

nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep

hypothermic low flow. J Neurol Sci. 2015 Oct; 357(1-2):119-25.

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered Long Non-

coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.

Experimental Neurology 2016; 277:162-70.

Wen Z, Yu D, Zhang W, Fan C, Hu L, Feng Y, Yang L, Wu Z, Chen R, Yin KJ, Mo X. Association

between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-

analysis of epidemiological observational studies. Ital J Pediatr. 2016 Feb 3; 42(1):12. doi:

10.1186/s13052-016-0222-2.

Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic TA, Chen YE, Yin KJ, Powell FL,

Martin PM, Grant MB, Busik JV. Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in

Diabetic Retinopathy. EBioMedicine. 2016 Sep;11:138-150. doi: 10.1016/j.ebiom.2016.08.013. Epub

2016 Aug 8.

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered Long Non-

coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.

Experimental Neurology 2016 Mar; 277:162-70. Citations 4

Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ. Long Non-coding RNA Malat1 regulates

cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 2017 February; 37(7):1797-

1806.

Tang X, Liu K, Hamblin MH, Yin KJ. Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic

brain injury. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0556-9. [Epub ahead of print]

Yang X, Liu K, Hamblin MH, Steller A, Chen J, Yin KJ. MicroRNA-15a/16-1 antagomir ameliorates

ischemic brain injury in experimental stroke. Stroke 2017 May 25. pii: STROKEAHA.117.017284. doi:

10.1161/STROKEAHA.117.017284. [Epub ahead of print]

Feng Zhang, MD, PhD, Assistant Professor

Leak RK, Li P, Zhang F (Co-first), Sulaiman HH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y,

Chen J. APE1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from

ischemic injury. Antioxid Redox Signal. 2015 Jan 10;22(2):135-48. PMID:24180454.

204

Wang J, Xia J, Zhang F, Shi Y, Wu Y, Pu H, Liou A, Leak RK, Yu X, Chen L, Chen J. Galectin-1-

secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury. Sci Rep. 2015

Apr 10;5:9621.

Sun BL , He MQ, Han XY, Sun JY, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,

Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal Delivery of Granulocyte Colony-

Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats. Mol

Neurobiol. 2016 Jan;53(1):320-30.

Fu XY, Yang MF, Cao MZ, Li DW, Yang XY, Sun JY, Zhang ZY, Mao LL, Zhang S, Wang FZ, Zhang

F, Fan CD, Sun BL. Strategy to Suppress Oxidative Damage-Induced Neurotoxicity in PC12 Cells by

Curcumin: the Role of ROS-Mediated DNA Damage and the MAPK and AKT Pathways. Mol Neurobiol.

2016 Jan;53(1):369-78.

Wang H, Shi H, Yu Q, Chen J, Zhang F, Gao Y. Sevoflurane Preconditioning Confers Neuroprotection

via Anti-apoptosis Effects. Acta Neurochir Suppl. 2016;121:55-61.

Shi Y, Zhang L, Pu H, Mao M, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak R, Keep R, Ji X,

and Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption

and long-term ischemic reperfusion brain injury. Nat Commun, 2016 Jan 27;7:10523.

Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,

Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref-1 facilitates recovery of gray and white matter and

neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67.

PMID: 27274063.

Yang T, Sun Y, Lu Z, Leak RK, and Zhang F. 2016. The impact of cerebrovascular aging on vascular

cognitive impairment and dementia. Ageing Res Rev. 2017 Mar;34:15-29. PMID: 27693240.

Sun Y, Yang T, Leak RK, Chen J, and Zhang F. Preventive and protective roles of dietary Nrf2 activators

against central nervous system diseases. CNS Neurol Disord Drug Targets. 2017; 16(3): 326-338. PMID:

28042770.

Sun Y, Yang T, Mao L, and Zhang F. Sulforaphane protects against brain diseases: roles of cytoprotective

enzymes. Austin J Cerebrovasc Dis & Stroke. 2017; 4(1): 1054.

Vascular Neurology

Ashutosh Jadhav, MD, PhD, Assistant Professor of Neurology

Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial Experience

with the AXERA 2 Femoral Access System in Neurovascular Procedures. Interventional Neuroradiology.

2015 May 26.

Grandhi R, Zhang X, Jadhav AP, Horowitz MB, Ducruet AF, Jankowitz BT, Jovin TG. Femoral

Arteriotomy Closure using the Mynx Vascular Closure Device: A Profile of Device Efficacy and

Complications. Interventional Neuroradiology. 2015 May 26.

Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in Patients

Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015

May 2.

205

Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right

sided weakness. J Clin Neurosci. 2015 Mar 18.

Tonetti DA, Jadhav AP, Ducruet AF. A rare marginal tentorial artery to ophthalmic artery anastomosis:

an anatomic case report. J Clin Neurosci. 2015 Apr;22(4):773-4.

Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and

right sided weakness. J Clin Neurosci. 2015 Mar 18.

Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in

Patients Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc

Dis. 2015 May 2.

Grandhi R, Zhang X, Jadhav AP, Horowitz MB, Ducruet AF, Jankowitz BT, Jovin TG. Femoral

Arteriotomy Closure using the Mynx Vascular Closure Device: A Profile of Device Efficacy and

Complications. Interventional Neuroradiology. 2015 May 26.

Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial

Experience with the AXERA 2 Femoral Access System in Neurovascular Procedures. Interventional

Neuroradiology. 2015 May 26.

Aghaebrahim A, Giurgiutiu DV, Jankowitz BT, Jovin T, Jadhav AP. NeuroImages: Ischemic stroke

after Pellet Embolization. Neurology 2015 Jun 9;84(23):2383.

Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar artery occlusion

and review of the literature. BMJ Case Rep. 2015 Jun 8;2015.

Rangaraju S, Streib C, Aghaebrahim A, Jadhav A, Frankel M, Jovin TG. Relationship Between Lesion

Topology and Clinical Outcome in Anterior Circulation Large Vessel Occlusions. Stroke. 2015

Jul;46(7):1787-92.

Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar artery occlusion

and review of the literature. J Neurointerv Surg. 2015 Jun 10.

Aspirin Response Test role in platelet transfusion following intracerebral hemorrhage. Engel-Haber E,

Horev A, Chablani P, Bornstein NM, Jadhav A, Jovin TG, Reddy V, Hammer MD. Clin Neurol Neurosurg. 2015 Oct;137:12-4.

Kenmuir CL, Jovin T, Jadhav A. Cerebral Venous Sinus Thrombosis in Users of a Hormonal Vaginal

Ring. Obstet Gynecol. 2015 Oct;126(4):830-3.

Haussen DC, Jadhav A, Jovin T, Grossberg J, Grigoryan M, Nahab F, Obideen M, Lima A, Aghaebrahim

A, Gulati D, Nogueira RG. Endovascular Management vs Intravenouse Thrombolysis for Acute Stroke

Secondary to Carotid Artery Dissection: Local Experience and Sysstematic Review. Neurosurgery. 2015

Oct 21. [Epub ahead of print]

Goyal M, Jadhav AP, Wilson AT, Nogueira RG, Menon BK. Shifting bottlenecks in acute stroke

treatment. J Neurointerv Surg. 2015 Dec 16. pii: neurintsurg-2015-012151.

Jadhav AP, Ducruet AF, Jankowitz BT, Jovin TG. Management of Bilateral Carotid Occlusive

Disease. Interv Neurol. 2016 Mar;4(3-4):96-103.

206

Aghaebrahim A, Streib C, Rangaraju S, Kenmuir CL, Giurgiutiu DV, Horev A, Saeed Y, Callaway

CW, Guyette FX, Martin-Gill C, Pacella C, Ducruet AF, Jankowitz BT, Jovin TG, Jadhav AP.

Streamlining door to recanalization processes in endovascular stroke therapy. J Neurointerv Surg.

2016 Apr 5.

Goyal M, Jadhav AP, Bonafe A, Diener H, Mendes Pereira V, Levy E, Baxter B, Jovin T, Jahan R,

Menon BK, Saver JL; SWIFT PRIME investigators. Analysis of Workflow and Time to Treatment

and the Effects on Outcome in Endovascular Treatment of Acute Ischemic Stroke: Results from the

SWIFT PRIME Randomized Controlled Trial. Radiology. 2016 Apr 19:160204.

Al-Bayati AR, Nichols J, Jovin TG, Jadhav AP. Thiamine Deficiency Presenting as Intraventricular

Hemorrhage. Stroke. 2016 May 10.

Levitt MR, Albuquerque FC, Gross BA, Moon K, Jadhav AP, Ducruet AF, Crowley RW. Venous

sinus stenting in patients without idiopathic intracranial hypertension. J Neurointerv Surg. 2016 May

19.

Reznik ME, Espinosa-Morales AD, Jumaa MA, Zaidi S, Ducruet AF, Jadhav AP. Endovascular

thrombectomy in the setting of aortic dissection. J Neurointerv Surg. 2016 May 19.

Paolini S, Jadhav AP. Teaching NeuroImages: Posterior reversible encephalopathy syndrome

resulting in hydrocephalus. Neurology. 2016 Jun 7;86(23):e242-3.

Jadhav AP, Wechsler LR. Patient selection for stroke thrombectomy: Is CT head good enough?

Neurology. 2016 Jul 19;87(3):242-3.

Goyal M, Jadhav AP. Denominator fallacy revisited. J Neurointerv Surg. 2016 Jul 28.

Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA,

Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An Educational and Administrative

Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine

Service. Am J Med. 2016 Sep 9.

Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O'Brien S, Fisher M, Haley EC, Khatri P, Saver J,

Levine S, Levy H, Rymer M, Wechsler L, Jadhav A, McNeil E, Waddy S, Pryor K. Selecting Patients

for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection. Stroke. 2016 Nov

1.

Haussen DC, Jadhav A, Rebello LC, Belagaje S, Anderson A, Jovin T, Aghaebrahim A, Gulati D,

Wells B, Frankel M, Nogueira RG. Internal Carotid Artery S-Shaped Curve as a Marker of

Fibromuscular Dysplasia in Dissection-Related Acute Ischemic Stroke. Interv Neurol. 2016 Sep;5(3-

4):185-192.

Jadhav AP, Aghaebrahim A, Horev A, Giurgiutiu DV, Ducruet AF, Jankowitz B, Jovin TG. Stent

Retriever-Mediated Manual Aspiration Thrombectomy for Acute Ischemic Stroke. Intervent Neurol

2017;6:16-24.

207

Kenmuir CL, Starr M, Jadhav AP. Restricted Diffusion of the Bilateral Inferior Olivary Nuclei After

Severe Hypoglycemia. Neurohospitalist 2016.

Jadhav AP, Aghaebrahim A, Horev A, Giurgiutiu DV, Ducruet AF, Jankowitz B, Jovin TG. Stent

Retriever-Mediated Manual Aspiration Thrombectomy for Acute Ischemic Stroke. Intervent Neurol

2017;6:16-24.

Alan N, Nwachuku E, Jovin TJ, Jankowitz BT, Jadhav AP, Ducruet AF. Management of iatrogenic

direct carotid cavernous fistula occurring during endovascular treatment of strokes. World

Neurosurg. 2017 Feb 6. pii: S1878-8750(17)30135-3.

Kashkoush AI, Ma H, Agarwal N, Panczykowski D, Tonetti D, Weiner GM, Ares W, Kenmuir C,

Jadhav A, Jovin T, Jankowitz BT, Gross BA. Cerebral venous sinus thrombosis in pregnancy and

puerperium: A pooled, systematic review. J Clin Neurosci. 2017 May;39:9-15.

Tudor Jovin, MD, Associate Professor of Neurology

Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial Experience

with the AXERA 2 Femoral Access System in Neurovascular Procedures, Interv Neuroradiol. 2015 May

26.

Khatri P, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B,

Ciccone A, Dávalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD,

Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SC, Mitchell P, Mocco J, Muir K, Nogueira RG,

Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White PM, Zaidat OO, Liebeskind

DS, Fulton R, Lees KR; VISTA-Endovascular Collaboration.State of acute endovascular therapy: report

from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke. 2015

Jun;46(6):1727-34.

Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ,

Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Devlin TG, Lopes

DK, Reddy V, du Mesnil de Rochemont R, Jahan R; SWIFT PRIME Investigators. Solitaire™ with the

Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT

PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire

revascularization device with IV tPA with IV tPA alone in acute ischemic stroke. Int J Stroke. 2015

Apr;10(3):439-48.

Chen SH, Grandhi R, Deibert CP, Jovin TG, Gardner PA, Ducruet AF. Coil herniation following intra-

arterial verapamil infusion for the treatment of cerebral vasospasm: Case report and literature review.

Interv Neuroradiol. 2015 Apr;21(2):184-7.

Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right

sided weakness. J Clin Neurosci. 2015 Mar 18. pii: S0967-5868(15)00066-1.

Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A.Predictors of Outcome in Patients

Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015

May 2.

208

Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ,

Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin

TG, Lopes DK, Reddy VK, de Rochemont RD, Singer OC, Jahan R; SWIFT PRIME Investigators. Stent-

Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke. N Engl J Med. 2015 Apr 17.

.

Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA,

Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL,

Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA,

Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB,

Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill

MD; ESCAPE Trial Investigators.Randomized assessment of rapid endovascular treatment of ischemic

stroke.N Engl J Med. 2015 Mar 12;372(11):1019-30.

Sheth SA, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO, Saver

JL; for the SWIFT Trialists. Rapid learning curve for Solitaire FR stent retriever therapy: evidence from

roll-in and randomized patients in the SWIFT trial.J Neurointerv Surg. 2015 Feb 12.

McTaggart RA, Jovin TG, Lansberg MG, Mlynash M, Jayaraman MV, Choudhri OA, Inoue M, Marks

MP, Albers GW; DEFUSE 2 Investigators. Alberta stroke program early computed tomographic scoring

performance in a series of patients undergoing computed tomography and MRI: reader agreement,

modality agreement, and outcome prediction. Stroke. 2015 Feb;46(2):407-12.

Menon BK, Qazi E, Nambiar V, Foster LD, Yeatts SD, Liebeskind D, Jovin TG, Goyal M, Hill MD,

Tomsick TA, Broderick JP, Demchuk AM; Interventional Management of Stroke III

InvestigatorsDifferential Effect of Baseline Computed Tomographic Angiography Collaterals on Clinical

Outcome in Patients Enrolled in the Interventional Management of Stroke III Trial. Stroke. 2015

May;46(5):1239-44.

Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, Román LS, Serena J, Abilleira

S, Ribó M, Millán M, Urra X, Cardona P, López-Cancio E, Tomasello A, Castaño C, Blasco J, Aja L,

Dorado L, Quesada H, Rubiera M, Hernandez-Pérez M, Goyal M, Demchuk AM, von Kummer R,

Gallofré M, Dávalos A; REVASCAT Trial Investigators. Thrombectomy within 8 Hours after Symptom

Onset in Ischemic Stroke. N Engl J Med. 2015 Apr 17. [Epub ahead of print]

Lopez-Cancio E, Salvat M, Cerda N, Jimenez M, Codas J, Llull L, Boned S, Cano LM, Lara B, Molina

C, Cobo E, Davalos A, Jovin TG, Serena J; REVASCAT investigators. Phone and Video-Based

Modalities of Central Blinded Adjudicaton of Modified Rankin Scores in an Endovascular Stroke Trial.

Stroke. 2015 Dec;46(12):3405-10.

Urra X, Abilleira S, Dorado L, Ribo M, Cardona P, Millan M, Chamorro A, Molina C, Bobo E, Davalos

A, Jovin TG, Gallofre M; Mechanical Thrombectomy in and Outside the REVASCAT Trial: Insights

From a Concurrent Population-Based Stroke Registry Catalan. Stroke Code and Reperfusion Consortium.

Stroke. 2015 Dec;46(12):3437-42.

Broderick JP, Berkhemer OA, Palesch YY, Dippel DW, Foster LD, Roos YB, van der Lugt A, Tomsick

TA, Majoie CB, van Zwam WH, Demchuck AM van Oostenbrugge RJ, Khatri P, Lingsma HF, Hill MD,

Roozenbeek B, Jauch EC, Jovin TG, Tan B, von Kummer R, Molina CA, Goyal M, Schonewille WJ,

Janis LS, Simpson KN; Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic

Stroke: Pooled Analysis of Interventional Management of Stroke III and Multicenter Randomized Clinical

Trial of Endovascular Therapyfor Acute Ischemic Stroke in the Netherlands Data. IMS II and MR CLEAN

Investigators. Stroke. 2015 Dec;46(12):3416-22.

209

Albers GW, Goyal M, Johan R, Bonafe A, Diener HC, Levy EI, Pereira VM, Cognard C, Cohen DJ,

Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin

TG, Lopes DL. Reddy VK, du Mesnil de Rochemont R, Singer OC, Bammer R, Saver JL. Ischemic core

and hypoperfusion volumes predict infarct size in SWIFT PRIME. Ann Neurol. 2015 Oct 17.

Chaisinanunkul N, Adeoye O, Lewis FJ, Grotta JC, Broderick J, Jovin TG, Nogueira RG, Elm JJ, Graves

T, Berry S, Lees KR, Barreto AD, Saver JL; DAWN Trial and MOST Trial Steering Committees;

Additional contributors from DAWN Trail Steering Committee. Adopting a Patient-Centered Approach

to Primary Outcome Analysis of Acute Stroke Trials Using a Uitlity-Weighted Modified Rankin Scale.

Stroke. 2015 Aug;46(8):2238-43.

Engel-Haber E, Horev A, Chablani P, Bornstein NM, Jadhav A, Jovin TG, Reddy V, Hammer MD,

Aspirin Response Test role in platelet transfusion following intracerebral hemorrhage. Clin Neurol

Neurosurg. 2015 Oct;137:12-4.

Rangaraju S, Streib C, Aghaebrahim A, Jadhav A, Frankel M, Joving TG. Relationship Between Lesion

Toplogy and Clinical Outcome in Anterior Circulation Large Vessel Occlusions. Stroke. 2015

Jul;46(7);1787-92.

Liebeskind DS, Jahan, R, Nogueira RG, Jovin TG, Lutsep HL, Saver JL; SWIFT Investigators. Early

arrival at the emergency department is associated with better collaterals, smaller established infarcts and

better clinical outcomes with endovascular stroke therapy: SWIFT study. J Neurointerv Surg. 2015 May

ll.

KhatriP, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B,

Ciccone A, Davalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD,

Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SC, Mitchell P, Mocco J, Muir K, Nogueira RG,

Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White PM, Zaidat OO, Liebesking

DS, Bulton R, Lees KR; VISTA-Endowvascular Collaboration. State of acute endovascular therapy:

report from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke. 2015

Jun;46(6):1727-34.

Chen SH, Grandhi R, Beibert CP, Jovin TG, Gardner PA, Ducruet AF. Coil herniation following intra-

arterial verapamil infusion for the treatment of cerebral vasospasm: Case report and literature review.

Interv Neuroradiol. 2015 Apt;21(2):184-7.

Palesch YY, Yeatts SD, Tomsick TA, Foster LD, Demchuk AM, Khatri P, Hill MD, Jauch EC, Jovin TG,

Yan B Von Kummer R, Molina CA, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson, C,

Spilker J, Carrrozzella J, Ryckborst KJ, Janis LS, Simpson A, Simpson KN, Broderick JP; Interventional

Management of Stroke III Investigators. Twelve-Month Clinical and Quality-of-Life Outcomes in the

Interventional Management of Stroke III Trial. Stroke. 2015 May;46(5):1321-7.

Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right

sided weakness. J Clin Neurosci. 2015 Jul;22(7):1199-200.

Menon BK, Qazi E, Nambiar V, Foster LD, Yeatts SD, Liebeskind D, Jovin TG, Goyal M, Mill MD<

Tomsick TA, Broderick JP, Demchuk AM; Interventiaonal Management of Stroke III Investigators.

Differential Effect of Baseline Computed in the Interventional Management of Stroke III Trial. Stroke.

2015 May;46(5):1239-44.

210

Sheth SA, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO, Saver

JL; Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomized

patients in the SWIFT trial. For the SWIFT Trialists. J Neurointerv Surg. 2015 Feb. 12.

Batal O, Jentzer J, Balaney B, Kolia N, Hickey G, Dardari Z, Reddy V, Jovin T, Hammer M, Forcsan J,

Schmidhofer M. The prognostic significance of troponin I elevation in acute ischemic stroke. J Crit Care.

2015 Sep 25.

Haussen DC, Jadhav A, Jovin T, Grossberg J, Grigoryan M, Nahab F, Obideen M, Lima A, Aghaebrahim

A, Gulati D, Nogueira RG. Endovascular Management vs Intravenous Thrombolysis for Acute Stroke

Secondary to Carotid Artery Dissection: Local Experience and systematic Review. Neurosurgery. 2015

Oct 21.

De Rango, P, Brown MM, Shaturvedi S, Howard VJ, Jovin T, Mazya MV, Paciaroni M, Manzone A,

Farchioni L, Caso V. Summary of Evidence on Early Carotid Intervention for Recently Symptomatic

Stenosis Based on Meta-Analysis of Current Risks. Stroke. 2015 Dec;46(12):3423-36.

Vagal AS, Sucharew H, Prabhakaran S, Khatri P, Jovin T, Michel P, Wintermark, M. Final infarct volume

discriminates outcome in mild strokes. Neuroradiol J. 2015 Aug;28(4):404-8.

MacIsaac RL, Khatri P, Bendszus M, Bracard S, Broderick J, Campbell B, Ciccone A, Davalos A, Davis

SM, Demchuk A, Diener HC, Dippel D, Donnan GA, Fiehler J, Fiorella D, Goyal M, Hacke W, Hill MD,

Jahan R, Jauch E, Jovin T, Kidwll CS, Liebeskind D, Majoie CB, Martins SC, Mitchell P, Mocco J, Muir

KW, Nogueira R, Saver JL, Schonewille, WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White

P, Zaidat O, Lees KR: VISTA Endovascular collaboration. A collaborative sequential meta-analysis of

individual patient data from randomized trials of endovascular therapy and tPAvs. tPA alone for acute

ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential

meta-analysis performed within the VISTA-Endovascular collaboration. Int J Stroke. 2015 Oct;10Suppl

A100:136-44.

Tomsick TA, Foster LD, Liebeskind DS, Hill MD, Carrozella J, Goyal M, von Kummer R, Demchuk AM,

Dzialowski I, Puetz V, Jovin T, Morales H, Palesch YY, Broderick J, Khatri P, Yeatts SD; IMS III

Investigators. Outcome Differences between Intra-Arterial Iso- and Low-Osmolality Iodinated

Radiographic Contract Media in the Interventional Management of Stroke III Trial. AJNR Am J Neuroradiol. 2015 Nov;36(11):2074-81.

Abou-CheblA, Yeatts SD, Yan B, Cockroft K, Goyal M, Jovin T, Khatri P, Meyers P, Spilker J, Sugg R,

Wartenberg KE, Tomsick T, Broderick J, Hill MD. Pact of eneral Anesthesia on Safety and Outcomes in

the Endovascular Arm of Intervential Management of Stroke (IMS) II Trial. Stroke. 2015 Aug;

46(8):2142-8.

Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar arter occlusion and

review of the literature. J Neurointerv Surg. 2015 Jun 10.

Ribo M, Molina CA, Cobo E, Cerda N, Tomasello A, Quesada H, De Miquel MA, Millan M, Castano C,

Urra X, Sanroman L, Davalos A, Jovin T; REVASCAT Trial Investigators. Association Between Time

to Reperfusion and Outcome Is Primarily Driven by The Time From Imaging to Reperfusion. Stroke. 2016

Apr;47(4):999-1004.

211

Lavine SD, Cockroft K, Hoh B, Bambakidis N, Khalessi AA, Woo H, Riina H, Siddiqui A, Hirsch JA,

Chong W, Rice H, Wenderoth J, Mitchell P, Coulthard A, Signh TJ, Phatorous C, Khangure M, Klurfan

P, terBrugge K, Iancu D, Funnarsson T, Jansen O, Muto M, Szikora I, Pierot L, Brouwer P, Gralla J,

Renowden S, Andersson T, Fiehler J, Turjman F, White P, Januel AC, Spelle L, Kulcsar Z, Chapot R,

Spelle L, Biondi A, Dima S, Taschner C, Szajner M, Krajina A, Sakai N, Matsumaru Y, Yoshimura S,

Ezura M, Fujinaka T, Iihara K, Ishii A, Higashi T, Hirohata M, Hydo A, Ito Y, Kawanishi M, Kiyosue H,

Kobayashi E, Kobayashi S, Kuwayama N, Matsumoto Y, Miyachi S, Murayama Y, Nagata I, Nakahara

I, Nemoto S, NiimiY, Oishi H, Satomi J, Satow T, Sugiu K, Tanaka M, Terada T, Yamagami H, Diaz O,

Lylyk P, Jayaraman MV, Patsalides A, Gandhi DC, Lee SK, Abrusso T, Albani B, Ansar SA, Arthur AS,

Baxter BW, Bulsara KR, Chen M, Delgado Almandoz JE, Fraser JF, Heck DV, Hetts SW, Hussian MS,

Klucznik RP, Leslie-Mawzi TM, Mack WJ, McTaggart RA, Meyers PM, Mocco J, Prestigiacomo CJ,

Pride GL, Rasmussen PA, Starke RM, Sunenshine PJ, Tarr RW, Frei DF, Ribo M, Nogueira RG, Zaidat

OO, Jovin T, Linfante I, Yavagal D, Liebeskind D, Novakovic R, Pongpech S, Rodesch G, Soderman M,

terBrugge K, Taylor A, Krings T, Orbach D, Biondi A, Picard L, Suh DC, Tanaka M, Shang HQ. Training

Guidelines for Endovascular Ischemic Stroke Intervention: An International Multi-Society Consensus

Document. AJNR Am J Neuroradiol. 2016 Feb 18.

Goyal M, Jadhav AP, Bonafe A, Diener H, Mendes Pereira V, Levy E, Baxter B, Jovin T, Jahan R, Menon

BK, Saver JL; SWIFT PRIME investigators. Analysis of Workflow and Time to Treatment and the

Effects on Outcome in Endovascular Treatment of Acute Ischemic Stroke: Results from the SWIFT

PRIME Randomized Controlled Trial. Radiology. 2016 Apr 19:160294.

Menon BK, Sajobi TT, Zhang Y, Rempel JL, Shuaib A,Thornton J, Williams D, Roy D, Poppe AY, Jovin

TG, Sapkota B, Baxter BW, Krings T, Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Lum C,

Dowlatshahi D, Eesa M, Lowerison MW, Kamal NR, Demchuk AM, Hill MD, Goyla M. Analysis of

Workflow and Time to Treatment on Thrombectomy Outcome in the ESCAPE Randoized Controlled

Trial. Circulation. 2016 Apr 13.

Lavine SD, Cockroft K, Hoh B, Bambakidis N, Khalessi AA, Woo H, Riina H, Siddiqui A, Hirsch JA,

Chong W, Rice H, Wenderoth J, Mitchell P, Coulthard A, Signh TJ, Phatorous C, Khangure M, Klurfan

P, terBrugge K, Iancu D, Funnarsson T, Jansen O, Muto M, Szikora I, Pierot L, Brouwer P, Gralla J,

Renowden S, Andersson T, Fiehler J, Turjman F, White P, Januel AC, Spelle L, Kulcsar Z, Chapot R,

Spelle L, Biondi A, Dima S, Taschner C, Szajner M, Krajina A, Sakai N, Matsumaru Y, Yoshimura S,

Ezura M, Fujinaka T, Iihara K, Ishii A, Higashi T, Hirohata M, Hyodo A, Ito Y, Kawanishi M, Kiyosue

H, Kobayashi E, Kobayashi S, Kuwayama N, Matsumato Y, Miyachi S, Murayama Y, Nagata I, Nakahara

I, Nemoto S, Niimi Y, Oishi H, Satomi J, Satow T, Sugiu K, Tanaka M, Terada T, Yamagami H, Diaz O,

Lylyk P, Jayaraman MV, Patsalides A, Gandhi CD, Lee SK, Abrusso T, Albani B, Ansari SA, Arthur AS,

Baxter BW, Bulsara KR, Chen M, Dalgado Almandoz JE, Fraser JF, Heck DV, Hetts SW, Hussain MS,

Klucznik RP, Leslie-Mawzi TM, Mack WJ, McTaggart RA, Meyers PM, Mocco J, Prestigiacomo CJ,

Pride GL, Rasmussen PA, Starke RM, Sunenshine PJ, Tarr RW, Frei DF, Ribo M, Nogueira RG, Zaidat

OO, Jovin T, Linfante I, Yavagal D, Liebeskind D, Novakovic R, Pongpech S, Rodesch G, Soderman M,

terBrugge K, Taylor A, Krings T, Orbach D, Biondi A. Picard L, Suh DC, Tanaka M, Zhang HQ. Training

guidelines for Endovascular Ischemic Stroke Intervention: An Internaitonal Multi-Society Consensus

Document. Neuroradiology. 2016 Apr 13.

English JD, Yavagal DR, Gupta R, Janardhan V, Zaidat OO, Xavier AR, Nogueira RG, Kirmani JF, Jovin

TG. Mechanical Thrombectomy-Ready Comprehensive Stroke Center Requirments and Endovascular

Stroke Systems of Care: Recommendations from the Endovascular Stroke Standards Committee of the

Society of Vascular and Interventional Neurology (SVIN). Interv Neurol. 2016 Mar;4(3-4):138-50. Epub

2016 Feb 19.

212

Rangaraju S, Frankel M, Jovin TG. Prognostic Value of the 24-Hour Neurological Examination in

Anterior Circulation Ischemic Stroke: A post hoc Analysis of Two Randomized Controlled Stroke Trials.

Interv Neurol. 2016 Mar;4(3-4):120-9. Doi: 10.1159/000442530. Eupub 2016 Jan 6.

Jadhav AP, Ducruet AF, Jankowitz BT, Jovin TG. Management of Bilateral Carotid Occlusive Disease.

Interv Neurol. 2016 Mar;4(3-4):96-103. Doi: 10.1159/000442530. Epub 2016 Jan 6.

Al-Ajlan FS, Goyal M, Demchuk AM, Minhas P, Sabiq F, Assis Z, Willinsky R, Monanera WJ, Rempel

JL, Shuaib A, Thornton J, Williams D, Roy D, Poppe AY, Jovin TG, Sapkota BL, Baxter BW, Krings T,

Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Lum C, Dowlatshahi D, Shankar JJ, Barber PA,

Hill MD, Menon BK; ESCAPE Trial Investigators. Intra-Arterial Therapy and Post-Treatment Infarct

Volumes: Insights From the ESCAPE Randomized Controlled Trial. Stroke. 2016 Mar;47(3):777-81.

Campbell BC, Hill MD, Rubiera M, Menon BK, Demchuk A, Donnan GA, Roy D, Thornton J, Dorado

L, Bonafe A, Levy EI, Diener HC, Hernandez-Perez M, Pereira VM, Blasco J, Quesada H, Rempel J,

Jahan R, Davis SM, Stouch BC, Mitchell PJ, Jovin TG, Saver JL, Goyal M. Safety and Efficacy of

Solitaire Stent Thrombectomy: Individual Patient Data Meta-Analysis of Randomized Trials. Stroke.

2016 Mar;47(3):798-806.

Leiva-Salinas C, Patrie JT, Xin W, Michel P, Jovin T, Wintermark M. Prediciton of Early Arterial

Recananilzation and Tissue Fate in the Selection of Patients With the Greatest Potential to Benefit From

Intravenous Tissue-Type Plasminogen Activator. Stroke. 2016 Feb;47(2):397-403. Epub 2015 Dec 22.

Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, Davalos A, Majoie CB,

van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg

LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millan M, Davis SM, Roy D, Thornton J, Roman

LS, Ribo M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD,

Jovin TG; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a

meta-analysis of individual patient data from five randomized trials. Lancet. 2016 Feb. 18.

Al-Ajlan FS, Goyal M, Demchuk AM, Minhas P, Sabiq F, Assis Z, Willinsky R, Montanera WJ, Tempel

JL, Shuaib A, Thornton J, Williams D, Roy D, Poppe AY, Jovin TG, Sapkota BL, Vaxter BW, Drings T,

Silver FL, Frei DF, Fanale C, Tampieri D, Teirtelbaum J, Lum C, Dowlatshahi D, Shankar JJ, Barber PA,

Hill MD, Menon BK; ESCAPE Trial Investigators. Intra-Arterial Therapy and Post-Treatment Infarct

Volumes: Insights from the ESCAPE Randomized Controlled Trial. Stroke. 2016 Mar;47(3):777-81.

Ribo M, Molina CA, Cobo E, Cerda N, Tomasello A, Quesada H, De Miquel MA, Millan M, Castano C,

Urra X, Sanroman L, Davalos A, Jovin T; REVASCAT Trial Investigators. Association Between Time

to Reperfusion and Outcome is Primarily Driven by the Time From Imaging to Reperfusion. Stroke. 2016

Apr;47(4):999-1004.

Warach SJ, Luby M, Albers GW, Bammer R, Bivard A, Campbell BC, Derdeyn C, Heit JJ, Khatri P,

Lansberg MG, Liebeskind DS, Majoie CB, Marks MP, Menon BK, Muir KW, Parsons MW, Vagal A,

Yoo AJ, Alexandroz AV, Baron JC Fiorella DJ, Furlan AJ, Puig J, Schellinger PD, Wintermark M; Stroke

Imaging Researh (STIR) and VISTA-Imaging Investigators. Imaging Research Roadmap III Imaging

Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and

Further Research Priorities. Stroke. 2016 May;47(5):1389-98.

Al-Bayati AR, Nichols J, Jovin TG, Jadhav AP. Thaimine Deficiency Presenting as Intraventricular

Hemorrhage. Stroke. 2016 Jun;47(6):e95-7.

213

Jovin TG, Albers GW, Liebeskind DS; STAIR IX Consortium. Stroke Treatment Academic Industry

Roundtable: The Next Generation of Endovascular Trials. Stroke. 2016 Oct;47(10):2655-65.

Saver JL, Goyla M, van der Lugt A, Menon BK, Majoie CB, Dippel DW, Campbell BC, Nogueira RG,

Demchuk AM, Tomesello A, Cardona P, Devlin TG, Frei DF, Du Mesnil de Rochemont R, Berkhemer

OA, Jovin TG, Siddiqui AH, van Zwam WH, Davis SM, Castano C, Sapkota BL, Fransen PS, Molina C,

van Oostenbrugge RJ, Chamarro A, Lingsma H, Silver FL, Donnan GA, Shuaib A, Brown S, Stouch B,

Mitchell PJ, Davalos A, Roos YB, Hill MD; HERMES Collaborators. Time to Treatment With

Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA. 2016 Sep

27;316(12):1279-88.

Sequeira D, Martin-Gill C, Kesinger MR, Thompson LR, Jovin TG, Massaro LM, Gayette FX.

Characterizing Strokes and Stroke Mimics Transported by Helicopter Emergency Medical Services.

Prehosp Emerg Care. 2016 Nov-Dec;20(6):723-728.

Ali Raza S, Xiang B, Jovin TG, Liebeskind DS, Shields R, Nogueira RG, Rangaraju S; Trevo2 study

group. Pittsburgh response to endovascular therapy score as a apre-treatment prognostic tool: External

validation in Trevo2. Int J Stroke. 2016 Nov. 3.

Trivedi D, Navid F, Balzer JR, Joshi R, Lacomis JM, Jovin TG, Althouse AD, Gleason TG. Aggressive

Aortic Arch and Carotid Replacement Strategy for Type A Aortic Dissecton Improves Neurologic

Outcomes. Ann Thorac Surg. 2016 Mar;101(3):896-903.

Ganesh A, Al-Ajlan FS, Sabiq F, Assis Z, Rempel JL, Butcher K, Thornton J, Kelly P, Roy D, Poppe AY,

Jovin TG, Devlin T, Baxter BW, Drings T, Casaubon LK, Frei DF, Choe H, Tampieri D, Teirtelbaum J,

Lum C, Mandzia J, Phillips SJ, Bang OY, Almekhlafi MA, Coutts SB, Barber PA, Sajobi T, Demchuk

AM, Eesa M, Hill MD, Goyal M, Menon BK; ESCAPE Trial Investigators..Infarc In a New Territory

After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment

for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to

Recanalization Times). Stroke. 2016 Nov 10. Pii: STROKEEAHA.116.014852.

Hou Q, Patrie JL, Xin W, Michel P, Jovin T, Eskandari A, Wintermark M. Number need to screen for

acute revascularization trials in sroke: Prognostic and predictive imaging biomarkers. Int J Stroke. 2016

Nov 2.

Haussen DC, Jadhav A, Rebello LC, Belagaje S, Anderson A, Jovin T, Aghaebrahim A, Gulati D, Wells

B, Frankel M, Nogueira RG. Internal Carotid Artery S-Shaped Curve as a Marker of Fibromuscular

Dysplasia in Dissection-Related Acute Ischemic Stroke. Interv Neurol. 2016 Sep;5(3-4):185-192.

Shams T, Zaidat O, Yavagal D, Xavier A, Jovin T, Janardhan V. Society of Vascualr and Interventional

Neurology (SVIN) Stroke Interventional Laboratory Consensus (SILC) Criteria: A 7M Management

Approach to Developing a Stroke Interventional Laboratory in the Era of Stroke Thrombectomy for Large

Vessel Occlusions. Interv Neurol. 2016 Jun;5(1-2):1-28.

Saposnik G, Goyal M, Majoie C, Dippel D, Roos Y, Demchuk A, Menon B, Mitchell P, Campbell B,

Davalos A, Jovin T, Hill MD; HERMES collavorators and the Stroke Outcomes Research working group

(SORCan). Visual aid tool to improve decision making in acute stroke care. Int J Stroke. 2016 Aug 16.

Rangaraju S, Jovin TG, Frankel M, Schonewille WJ, Algra A, Kappelle LJ, Nogueira RG; BASICS Study

Group..Neurologic Examination at 24 to 48 Hours Predicts Funtional Outcomes in Basilary Artery

Occlusion Stroke. Stroke. 2016 Oct;47(10):2534-40.

214

Brinjiki W, Duffy S, Burrows A, Hacke W, Liebeskind D, Majoie CB, Dippel DW, Siddiqui AH, Khatri

P, Baxter B, Nogeuira R, Gounis M, Jovin T, Kallmes DF. Correlation of imaging and histopathology of

thrombi in acute ischemic stroke with etiology and outcome: a systematic review. J Neurointerv Surg. 2016 May 10.

Lopez-Cancio E, Jovin TG, Cobo E, Cerda N, Jimenez M, Gomis M, Hernandez-Perez M, Caceres C,

Cardona P, Lara L, Renu A, Llull L, Boned S, Muchada M, Davalos A. Endovascular treatment improves

cognition after stroke. A secondary analysis of REVASCAT trial. Neurology 2017 (in Press)

Shireman T, Wang K, Saver J, Goyal M, Bonafe A, Diener HC, Elad Levy E, Pereira VM, Albers G,

Cognard C, Hacke W, Jansen O, Jovin TG, Mattle H, Nogueira N, Siddiqui A, Yavagal D, Devlin T,

Lopes D, Reddy V, du Mesnil de Rochemont R, Jahan R, Vilain K, House J, Lee JM and Cohen D. Cost-

effectiveness of Solitaire Stent Retriver Thrombectomy for Acute Ischemic Stroke: Results from SWIFT-

PRIME. Stroke 2017 (in Press)

Davalos A, Cobo E, Molina C, Chamorro A, Miquel MA, San Roman L, Serena J, Lopez-Cancio, E, Ribo

M, Millan M, Urra X, Cardona P, Tomasello A, Castano C, Plasco J, Aja L, Rubiera M, Gomis M, Renu

A, Lara B, Marti-Fabregas J, Jankowiwtz BJ, Cerda N, Jovin TG; for the REVASCAT Trial Investigators.

Benefit of thrombectomy is sustained at 12 months post treatment for acute ischemic stroke. One year

results of the REVASCAT Trial. Lancet Neurology. 2017 (in Press).

Vivek Reddy, MD, Assistant Professor of Neurology

Kenmuir CL, Hammer M, Jovin T. Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in Patients

Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015

Jul;24(7):1685-9.doi:10.1016/j.jstrokecerebrovasdis.2015.03.042. Epub 2015 May 2.

Saver JL, Goyal M, Bonafe A, Diener HC, Levy El, Pereira VM, Albers GW, Cognard C, Cohen DJ,

Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Devlin TG, Lopes

DK, Reddy V, du Mesnil de Rochemont R, Jahan R; SWIFT PRIME Investigators. Solitaire with the

Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT

PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire

revascularization device with IV tPA with IV tPA alone in acute ischemic stroke. Int J Stroke, 2015

Apr;10(3):439-48. Doi:10.1111/ijs.12459.

Saver JL, Goyal M, Bonafe A, Diener HC, Levy El, Pereira VM, Albers GW, Cognard C, Cohen DJ,

Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin

TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahan R; SWOFT PRIME

Investigators. Stent-retriever thromectormy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015 June 11;372(24):2285-95. Doi:10.1056/NEJMoa1415061. Epub 2015 Apr 17.

Albers GW, Goyal M, Jahan R, Bonafe A, Diener HC, Levy El, Pereira VM, Cognard C, Cohen DJ, Hacke

W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG,

Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Bammer R, Saver JL. Ischemic core and

hypoperfusion volumes predict infarct size in SWIFT PRIME. Ann Neurol. 2015 Oct 17.

Doi:10.1002/ana.24543.

Batal O, Jentzer J, Balaney B, Kolia N, Hickey G, Dardari Z, Reddy V, Jovin T, Hammer M, Gorcsan J,

Schmidhofer M. The prognostic significance of troponin I elevation in acute ischemic stroke. J Crit Care.

2016 Feb;31(1):41-7. Doi:10.1016/j.jcrc.2015.09.018. Epub 2015 Sep 25.

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Marcelo Rocha, MD, PhD, Assistant Professor of Neurology

Rocha M, Delfyett WT, Agarwal V, Aghaebrahim A, Jadhav A and Jovin T. Diagnostic Accuracy of

Emergency CT Angiography for Presumed Tandem Internal Carotid Artery Occlusion before Acute

Endovascular Therapy (2017) Journal of Neurointerventional Surgery (accepted).

Rocha M and Jovin TG Fast Versus Slow Progressors of Infarct Growth in Large Vessel Occlusion

Stroke: Clinical and Research Implications (2017) Stroke 48(9):2621-2627.

Jadhav AP, Kenmuir CL, Aghaebrahim A, Wechsler LR, Hammer MD, Starr MT, Molyneaux BJ, Rocha

M, Guyette FX, Martin-Gill C, Ducruet AF, Gross BA, Jankowitz BT and Jovin TJ. Inter-facility transfer

directly to the neuroangiography suite in acute ischemic stroke patients undergoing thrombectomy (2017)

Stroke DOI: 10.1161/STROKEAHA.117.016946.

Matthew Starr, MD, Assistant Professor of Neurology

Jadhav AP, Bouslama M, Aghaebrahim A, Rebello LC, Starr MT, Haussen DC, Ranginani M, Whalin

MK, Jovin TG, Nogueira RG, Monitored Anesthesia Care vs. Intubation for Vertebrobasilar Stroke

Endovascular Therapy. JAMA Neurol. 2017;74(6):704-709. Doi:10.1001/jamaneurol.2017.0192.

Jadhav AP, Kenmuir CL, Aghaebrahim A, Limaye K, Wechsler LR, Hammer MD, Starr MT et al.

Interfacility Transfer Directly to the Neuroangiography Suite in Acute Ischemic Stroke Patients

Undergoing Thrombectomy. Stroke. 2017;48:00-00.)

Lawrence Wechsler, MD, Professor and Chair of Neurology

Wechsler LR. Advantages and limitations of teleneurology. JAMA Neurol 2015; 72:349-354.

Meschia JF, Hopkins LN, Altafullah I, Wechsler LR, Stotts G, Gonzales NR, Voeks JH, Howard G, Brott

TG. Time from symptoms to carotid endarterectomy or stenting and perioperative risk. Stroke 2015;

46:3540-3542.

Rosenfield K, Matsumura JS, Chaturvedi S, Riles T. Ansel GM, Metzger DC, Wechsler L, Jaff MR, Gray

W, ACT I Investigators. Randomized trial of stent versus surgery for asymptomatic carotid stenosis.

NEJM, 2016; 374:1011-1020.

Warach SJ, Luby M, Algers GW, Bammer R, Bivard A, Campbell BCV, Derdeyn C, Heit JJ, Khatri P,

Lansberg MG, Liebeskind DS, Majoie CBLM, Marks MP, Menon BK, Muir KW, Parsons MW, Vagal

A, Yoo AJ, Alexandrov AV, Baron J-C, Fiorella DJ, Furlan AJ, Puig J. Schellinger PD, Wintermark M,

for the Stroke Imaging Research (STIR) and VISTA-Imaging Investigators. Acute stroke imaging

research roadmap III imaging selection and outcomes in acute stroke reperfusion clinical trials. Stroke

2016;47:1389-1398

Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA,

Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks

JH, Hobson RW 2nd; CREST Investigators. Long-term results of stenting versus endarterectomy for

carotid-artery stenosis. NEJM 2016; 17:374(11):1021-31. Epub 2016 Feb 18.

Lees KR, Khatri P, STAIR IX Collaborators. Stroke treatment academic industry roundtable

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Jadhav AP, Wechsler LR. Patient selection for stroke thrombectomy: Is CT head good enough?

Neurology 2016; 87:242-243.

Steinberg GK, Kondziolka D, Wechsler LR, Lunsford LD, Coburn ML, Billigen JB, Kim AS, Johnson

JN, Bates D, King B, Case C, McGrogan M, Yankee EW, Schwartz NE. Clinical outcomes of transplanted

modified bone marrow-derived mesenchymal stem cells in stroke: A phase 1/2a study. Stroke 2016;

47:1817-1824.

Lees KR, Khatri P, STAIR IX Collaborators. Stroke treatment academic industry roundtable

recommendations for individual data pooling analyses in stroke. Stroke 2016; 47:2154-2159.

Wechsler LR, Demaerschalk BM, Schwamm LH, Adeoye OM, Audebert HJ, Fanale CV, Hess DC,

Majersik JJ, Nystrom KV, Reeves MJ, Rosamond WD, Switzer JA; on behalf of the American Heart

Association Stroke Council; Council on Epidemiology and Prevention; and Council on Quality of Care

and Outcomes Research. Telemedicine Quality and Outcomes in Stroke. Published online ahead of print.

Stroke 2016/Stroke 2017; 48:e3-e25.

Cramer SC, Wolf SL, Adams HP Jr, Chen D, Dromerick AW, Dunning K, Ellerbe C, Grande A, Janis S,

Lansberg MG, Lazar RM, Palesch YY, Richards L, Roth E, Savitz SI, Wechsler LR, Wintermark M,

Broderick JP. Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National

Institutes of Health StrokeNet. Stroke. 2017 Mar; 48(3):813-819.

Northshore Neurology

Lazarus Mayoglou, DO

Martín-Alguacil N, Cooper RS, Aardsma N, Mayoglou L, Pfaff D, Schober J. Terminal innervation of the

male genitalia, cutaneous sensory receptors of the male foreskin. Clin Anat. 2015 Apr;28(3):385-91. doi:

10.1002/ca.22501. Epub 2015 Feb 2. PubMed PMID: 25644189.

Schober J, Aardsma N, Mayoglou L, Pfaff D, Martín-Alguacil N. Terminal innervation of female

genitalia, cutaneous sensory receptors of the epithelium of the labia minora. Clin Anat. 2015

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