Department of Biochemistry

Research

The main areas of research in our Department includes Membrane Biochemistry, Cancer

Biology, Neurogerontology, Reproductive Biology etc., We have produced more than 20 PhD

students who have got placed as scientist, post doctoral fellows in various leading international

institutes in USA, Korea, Sweden. Within the short span time, the Department has grown into a

vibrant academic department and research centre in Biochemistry, where we have made great stride

in higher education, research and extension activities in the area of specialization. The Department

was recognized for DST-FIST Program in the year 2012. The department has generated funds worth

five plus crores for Research and Infrastructure from various funding agencies like CSIR, NFMP,

DST, DBT, ICMR and UGC etc., To add on to the credentials, more high impact factor publications

has been made in well reputed Journals and published many book chapters in the core area of

research. The department has hosted many national level conferences and workshops benefiting

students.

S. No. Name Reg. No. Fellowship

1. Karthik S 6354 UGC – Project Fellow

2. Sankar R 44356 DST INSPIRE – SRF

3. Mohanraj S 4818 ICMR - JRF

4. Premkumar P 6403 DST – Project Fellow

5. Sivasangari B 4933 DBT – JRF

6. Sathya M 39336 UGC – Project Assistant

7. Karthick C 5195 CSIR – SRF

8. Balamurugan R 33504 UGC – Project Fellow

9. Selvaraju K 22214 CSIR - SRF

10. Varunkumar K 45376

DST – JRF

ICMR - SRF

11. Anusha C 30014 URF – BDU

12. William James 42467 DST – PURSE

13. Sivapraksam 43854 NMPB - JRF

14. Vijayakumar R 42234 NMPB – SRF

CSIR - SRF

15. Lakshmi Priya K 45375 DST – INSPIRE - SRF

16. Arun K 7905 URF – BDU

ICMR - SRF

17. Sridharan J 32851 URF – BDU

18. Periyasamy S 47364 URF – BDU

19. Uma Maheswara Rao D 34407 UGC – RGNF – SRF

20. Saravanan K 34406 DST – SERB – JRF

21. Anantha Lakshmi N 7705 DST – (WOS – A) – PI

22. Mahesh Kumar K 7941 DBT – JRF

23. Palanimuthu DST – Post –Doc

24. Bhanupriya N 45145 DST – INSPIRE – JRF

25. Vennila S 29336 DST – WOS-A – SRF

26. Ravi C 32367 SERB – JRF

27. Roseline M 7868 URF – BDU

28. Nithya G 14727 URF – BDU

29. Subitha M 5486 URF - BDU

30. Prabhu S 25991 DST – PURSE II - JRF

31. Suhadha Parveen 25862 LADY TATA – JRF

32. Roshan 003280 DBT- JRF

Details of Fellowships being availed by the

Research Scholars/Project Staff

Citations

Research & Consultancy Projects

Completed Projects

S.

No.

Principal

Investigator

Project Title Period Funding

Agency

Amount

₹ (in

lakhs) From To

1. Dr. M.

Anusuyadevi

Jayachandran

Does Sirtuin Proteins attenuate

Alzheimer’s disease pathogenesis

by regulating cholesterol

homeostasis? An approach to

understand biochemical concept

behind AD pathology.

2012 2015 DST 23.69

2. Dr. M.

Anusuyadevi

Jayachandran

Do mitochondria dysfunction

provide possible grounds for

Amyloid (Aβ 42) formation

during aging- intervention of

sirtuins in counteracting multiple

stage pathophysiology with

specific reference to AD

2010 2015 DBT 13.80

3. Dr. M.

Anusuyadevi

Jayachandran

Identification of the Intracellular

localization of α, β and γ secretase

and APP cleavage pattern in

young and aged rat brain region:

an understanding towards the

underlying mechanism behind AD

pathology.

2012 2015 UGC 13.48

4. Dr. M.

Anusuyadevi

Jayachandran

Hyperinsulinemia influences

autophagy and mitochondrial

biogenesis: A possible mechanism

of neuronal ageing.

2013 2016 ICMR 50

5. Dr. Vasanthi

Nachiappan

Remodeling of fatty acid in

phosphatidyl choline rat liver as a

model system

2008 2011 UGC 10.89

6. Dr. Vasanthi

Nachiappan

Endoplasmic reticulum (ER)

stress induced autophagy in

Saccharomyces cerevisiae and the

implication in Phospholipid.

2012 2015 CSIR 22.92

7. Dr. Vasanthi

Nachiappan

Characterization of active

principle from Cassia auriculata

as a potential drug for

hyperlipidemia and cardiovascular

disease

2013 2017 NMPB 23.52

8. Dr. C.

Prahalathan

Evaluation of the Effect of Acute

Inflammation on Histone H3

Modifications in Rat Testis and

Its Implications in Testicular

Steroidogenesis

2011 2014 DBT 21.63

9. Dr. C.

Prahalathan

A Study on Proinflammatory

Cytokines Mediated Histone H3

Modifications in R2C Leydig

2011 2014 ICMR 20.15

Cells and Its Implications in

Regulation of Testicular

Steroidogenesis

10. Dr. C.

Prahalathan

Evaluation of the Effect of Acute

Inflammation on Histone H3

Modifications in Rat Pancreas and

Its Implications in Insulin Gene

Transcription

2011 2014 UGC 13.17

11. Dr. C.

Prahalathan

Role of Class II Histone

Deacetylases in Regulation of

Insulin Gene Transcription

2012 2015 DST 16.70

12. Dr. V.

Ravikumar

Nano encapsulation of

Suberoylanilide hydroxamic acid

(SAHA): an attempt to improve

anticancer activity in non-small

cell lung cancer cell lines.

2011 2014 UGC 11.14

13. Dr. V.

Ravikumar

Synergistic Interaction Of The

Histone Deacetylase Inhibitor

With The Proteasome Inhibitor In

Lung Cancer.

2012 2015 DST 22.75

14. Dr. A.

Antony

Joseph

Velanganni

Molecular characterization of

Constitutive and Consensus

miRNA Expression Profiles in

NCI-60 Panel of Human Cancer

Cell Lines

2012 2015 UGC 13.92

15. Dr. A.

Antony

Joseph

Velanganni

Exploration of hTERT gene

inhibition in cervical cancer cells

by nanoencapsulated hTERT-

siRNA

2014 2017 DST-

(WOS-

A)

24.13

16. Dr. A.

Antony

Joseph

Velanganni

RNAi mediated Functional

Analysis of RNA induced

Silencing Complex (RISC) and its

Component AEG-1 that induce

the Expression of Transcription

Factor LSF in Hepatocellular

Carcinoma

2015 2018 DBT 25.00

Ongoing Projects

S.

No.

Principal

Investigator

Project Title Period Funding

Agency

Amount

₹ (in

lakhs)

From To

1. Dr. M.

Anusuyadevi

Jayachandran

Assessment of the effect of aspirin

treatment on neural stem cells and

the regulation of hippocampal

neurogenesis in the adult brain of the

experimental rodents: A non-invasive

attempt for the brain regeneration

2017 2020 SERB 52.00

2. Dr. Vasanthi

Nachiappan

High throughput screening &

molecular analysis of GCR1

transcription factor and its impact on

the binding motif of OPI3 promoter

in Saccharomyces cerevisae

2017 2020 SERB 47.92

3. Dr. C.

Prahalathan

Elucidation of the role of SIRT4 in

testicular steroidogenesis 2018 2021 SERB 38.20

4. Dr. V.

Ravikumar

Investigation on acetylation

dependent activation of Notch

signaling pathway by HDAC

inhibitors - A possible mechanism

for drug resistance and survival upon

HDAC inhibition therapy in NSCLC

cell lines

2016 2019 SERB 28.99

5. Dr. A.

Antony

Joseph

Velanganni

Social Support and Reproductive

Autonomy of Visually Challenged

Women in the Rural Districts of

Tamil Nadu

2017 2019 ICMR-

ICSSR

13.75

Collaborative Projects

S.

No

Agency Period Project Title Budget

(Rs. In

lakhs) From To

1 NMPB 2012 2015 Characerization Of Active Principles From

Cassia Auriculata As A Potential Drug For

Hyperlilpidemia And Cardiovascular Diseases

23.52

2 CSIR 2012 2015 Endoplasmic reticulum stress induced

autophagy in Saccharomyces cerevisiae and

the implications in phospholipids

22.92

3 DBT 2012 2015

Studies on Potential Oncogenic Role of the

Transcription Factor Nsep1 Association with

the Overexpressed Rps27a in Human

Hepatocellular Carcinoma (HCC)

27.07

4 CSIR 2012 2015 Novel MASP-2 inhibitor from Indian

medicinal plants for protection against

myocardial infraction

16.00

5 DBT 2012 2016 Structural Exploration of Recombinant Mouse

Seminal Vesicle Spink-3 Receptor on Sperm 29.87

6 SERB 2018 2021

Assessment of the effect of aspirin treatment

on neural stem cells and the regulation of

hippocampal neurogenesis in the adult brain

of the experimental rodents: A non-invasive

attempt for the brain regeneration

52.00

.

List of Research Publications since 2013 to 2018

1. Anandhi R, Annadurai T, Anitha TS, Muralidharan AR, Najmunnisha K, Nachiappan V,

Thomas PA, Geraldine (2013). Antihypercholesterolemic and antioxidative effects of an extract

of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-

1339-induced hypercholesterolemic rats. J Physiol Biochem. 69(2):313-23. doi: 10.1007/s13105-

012-0215-6.

2. Shanmughapriya S, Nachiappan V, Natarajaseenivasan K (2013) BRCA1 and BRCA2

mutations in the ovarian cancer population across race and ethnicity: special reference to

Asia. Oncology. 84(4):226-32. doi: 10.1159/000346593.

3. Muthukumar K, Nachiappan V. (2013) Phosphatidylethanolamine from phosphatidylserine

decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces

cerevisiae. Cell Biochem Biophys. 67(3):1353-63. doi: 10.1007/s12013-013-9667-8.

1. Muthusamy K, Singh KhD, Chinnasamy S, Nagamani S, Krishnasamy G, Thiyagarajan C,

Premkumar P, Anusuyadevi M. High throughput virtual screening and E-pharmacophore

filtering in the discovery of new BACE-1 inhibitors. Interdiscip Sci. 2013 Jun;5(2):119-26.

2. Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and

anticancer activity. Sankar R, Karthik A, Prabu A, Karthik S, Shivashangari KS, Ravikumar V,

Colloids and Surfaces B: Biointerfaces. 108:80-84, 2013.

3. Vishnu Varthini L Selvaraju K, Srinivasan M, Nachiappan V. (2014) ROG1 encodes a

monoacylglycerol lipase in Saccharomyces cerevisiae. FEBS Lett. pii: S0014-5793(14)00824-2.

doi: 10.1016/j.febslet.2014.11.019.

4. Selvaraju K, Rajakumar S, Nachiappan V. (2014) Identification of a phospholipase B encoded

by the LPL1 gene in Saccharomyces cerevisiae. Biochim Biophys Acta. 1841(10):1383-1392.

doi: 10.1016/j.bbalip.2014.06.013

5. Vijayaraj P, Sivaprakasam C, Varthini LV, Sarkar M, Nachiappan V. (2014) In vitro exposure

of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced

phospholipase A2 activity. Toxicol In Vitro. 28(6):1097-105. doi: 10.1016/j.tiv.2014.05.001.

6. Kalyani D, Jyothi K, Sivaprakasam C, Nachiappan V. (2014) Spectroscopic and molecular

modeling studies on the interactions of N-Methylformamide with superoxide

dismutase. Spectrochim Acta A Mol Biomol Spectrosc. 124:148-52. doi:

10.1016/j.saa.2014.01.013

7. James AW, Nachiappan V. (2014) Phosphate transporter mediated lipid accumulation in

Saccharomyces cerevisiae under phosphate starvation conditions.Bioresour Technol. 151:100-5.

doi: 10.1016/j.biortech.2013.10.054

8. Kannan A, Prahalathan C. Effect of hyperglycaemia on the expression of aquaporins in

diabetic rat testis. Diabetologia. 2014:57;s535-36.

9. Sadasivam M, Ramatchandirin B, Balakrishnan S, Selvaraj K, Prahalathan C. The role of

phosphoenolpyruvate carboxykinase in neuronal steroidogenesis under acute inflammation.

Gene. 2014;552:249-54.

10. Balakrishnan S, Sadasivam M, Kannan A, Selvam AP, Prahalathan C. Glucose modulates Pax6

expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells. Life Sci.

2014;109:1-7.

11. Sadasivam M, Ramatchandirin B, Ayyanar A, Prahalathan C. Bacterial lipopolysaccharide

differently modulates steroidogenic enzymes gene expressions in brain and testis in rats.

Neurosci Res. 2014;83:81-8.

12. Biocompatibility and biodistribution of suberoylanilide hydroxamic acid loaded poly (DL-

lactide-co-glycolide) nanoparticles for targeted drug delivery in cancer. Sankar R, Ravikumar

V. Biomedicine & Pharmacotherapy 68 (2014) 865–871, 2014.

13. Growth inhibition of bloom forming cyanobacterium Microcystis aeruginosa by green route

fabricated copper oxide nanoparticles. Sankar R, Balaji Prasath B, Nandakumar R, Santhanam P,

Shivashangari KS, Ravikumar V, Journal of Environmental and Pollution Research DOI

10.1007/s11356-014-3362-1, 2014.

14. Anticancer activity of Ficus religiosa engineered copper oxide nanoparticles. Sankar R,

Maheswari R, Karthik S, Shivashangari KS, Ravikumar V, Materials Science and Engineering

C 44 (2014) 234–239, 2014.

15. Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in

wistar -albino rats. Sankar R, Dhivya R, Shivashangari KS, Ravikumar V, J Mater Sci Mater

Med. 25, 1701-1708, 2014.

16. Green synthesis of colloidal copper oxide nanoparticles using Carica papaya and its application

in photocatalytic dye degradation. Sankar R, Manikandan P, Malarvizhi V, Fathima T,

Shivashangari KS, RavikumarV, Spectrochim Acta A Mol Biomol Spectrosc. 121:746-50,

2014.

17. Anbazahan SM, Shanthi Mari LS, Yogeshwari G, Jagruthi C, Thirumurugan R, Arockiaraj J, A.

Antony Joseph Velanganni, Krishnamoorthy P, Balasundaram C, Harikrishnan R (2014).

Immune Response and Disease Resistance of Carotenoids Supplementation Diet in Cyprinus

Carpio against Aeromonas Hydrophila. Fish Shellfish Immunol. Jun 20;40(1):9-13.

18. Sivaprakasam C, Nachiappan V. (2015) Modulatory effect of cadmium on the expression of

phospholipase A2 and proinflammatory genes in rat testis. Environ Toxicol. doi:

10.1002/tox.22124.

19. Moorthi, P., Premkumar, P., Priyanka, R., Jayachandran, K. S., Anusuyadevi, M. Pathological

changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and

memory loss: Positive clue toward SAD. Neuroscience. 2015 Jun 1;301:90-105.

20. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. TNF-α mediated suppression

of Leydig cell steroidogenesis involves DAX-1. Inflammation Res. 2015;64:549-56.

21. Sadasivam M, Ramatchandirin B, Balakrishnan S, Prahalathan C. HDAC7 modulates TNF-α

mediated suppression of Leydig cell steroidogenesis. Mol Cell Biochem. 2015;406:83-90.

22. Inhibition of pathogenic bacterial growth on excision wounds by green synthesized copper oxide

nanoparticles leads to accelerated wound healing activity in Wistar Albino rats. R. Sankar, A.

Baskaran, K.S. Shivashangari, V. Ravikumar, J Mater Sci Mater Med. 26:214, 2015.

23. Chemopreventive potential of fungal taxol against 7, 12-dimethylbenz[a]anthracene induced

mammary gland carcinogenesis in Sprague Dawley rats. Kathamuthu Gokul Raj, Ranganathan

Chidambaram, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Mohan Pandi. Eur J

Pharmacol. Nov 15; 767:108-18, 2015.

24. Single and double chain surfactant–cobalt (III) complexes: the impact of hydrophobicity on the

interaction with calf thymus DNA, and their biological activities. Selva kumar Veeralakshmi

selvan Nehru, Gopal Sabapathi, Sankaralingam Arunachalam, Ponnambalam Vennuvanalingam,

Ponnuchamy Kumar, Chidambaram Anusha, Vilwanathan Ravikumar. RSC Adv., 2015, 5,

31746-31758, 2015.

25. Nanostructured delivery growth system for suberoylanilide hydroxamic acid against lung cancer

cells. Sankar R, Karthik S, Subramanian N, Venkateshwaran K, Sonnemann J, Ravikumar V.

Materials Science and Engineering: C. Volume 51, 1 June 2015, Pages 362–368, 2015.

26. Krishnamoorthy Lakshmi Priya and Arockiam Antony Joseph Velanganni (2015). Therapeutic

potential of doxorubicin loaded poly (d, l-lacticco-glycolic acid) against p-

dimethylaminoazobenzene induced liver cancer. Int. J. Phar. and Bio Sci. 6(4):511-

521.(IF:0.36).

27. Selvaraj Rajakumar and Vasanthi Nachiappan (2016) Lipid droplets alleviate cadmium

induced cytotoxicity in Saccharomyces cerevisiae. Received 4th May 2016 , Accepted 3rd

October 2016. DOI: 10.1039/C6TX00187D (Paper) Toxicol. Res., 2017, 6, 30-41.

28. Kannan M, Sivaprakasam C, Prinz WA, Nachiappan V (2016) Endoplasmic reticulum stress

affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic

reticulum in S.cerevisiae. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1959-1967. doi:

10.1016/j.bbalip.2016.09.015.

29. James AW, Gowsalya R, Nachiappan V (2016) Dolichyl pyrophosphate phosphatase-mediated

N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochim

Biophys Acta.1861(11):1705-1718. doi: 10.1016/j.bbalip.2016.08.004. [Epub ahead of print]

30. Rajakumar S, Bhanupriya N, Ravi C, Nachiappan V (2016) Endoplasmic reticulum stress and

calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces

cerevisiae. Cell Stress Chaperones.21(5):895-906. doi: 10.1007/s12192-016-0714-4. Epub 2016

Jun 25.

31. Raj A, Nachiappan V (2016) Exposure to benzene metabolites causes oxidative damage in

Saccharomyces cerevisiae. Antonie Van Leeuwenhoek. 109(6):841-54. doi: 10.1007/s10482-

016-0684-7. Epub 2016 Mar 25.

32. Rajakumar S, Ravi C, Nachiappan V (2016) Defect of zinc transporter ZRT1 ameliorates

cadmium induced lipid accumulation in Saccharomyces cerevisiae. Metallomics. 8(4):453-60.

doi: 10.1039/c6mt00005c. Epub 2016 Mar 21.

33. Selvaraju K, Gowsalya R, Vijayakumar R, Nachiappan V (2016) MGL2/YMR210w encodes a

monoacylglycerol lipase in Saccharomyces cerevisiae. FEBS Lett. 590(8):1174-86. doi:

10.1002/1873-3468.12136.

34. Sathya, M., Moorthi, P., Premkumar, P., Kandasamy, M., Jayachandran, K. S., Anusuyadevi,

M. Resveratrol intervenes cholesterol and isoprenoids mediated amyloidogenic processing of

AβPP in Familial Alzheimer’s disease. Journal of Alzheimer's Disease Preprint (2016): 1-22.

35. Karthick, C., Periyasamy, S., Jeyachandran, K. S., Anusuyadevi, M. Intrahippocampal

Administration of Ibotenic Acid Induced Cholinergic Dysfunction via NR2A/NR2B Expression:

Implications of Resveratrol against Alzheimer Disease Pathophysiology. Front Mol Neurosci

2016, 9:28.

36. Ramatchandirin B, Sadasivam M, Kannan A, Prahalathan C. Sirtuin4 regulates

lipopolysaccharide mediated Leydig cell dysfunction J Cell Biochem. 2016;117:904-16.

37. Kalaiarasi, A., Anusha, C., Sankar, R., Rajasekaran, S., John Marshal, J., Muthusamy, K.,

&Ravikumar, V. (2016). Plant isoquinoline alkaloid berberine exhibits chromatin remodeling

by modulation of histone deacetylase to induce growth arrest and apoptosis in the A549 cell line.

Journal of agricultural and food chemistry, 64(50), 9542-9550.

38. Mathuram, T. L., Ravikumar, V., Reece, L. M., Karthik, S., Sasikumar, C. S., & Cherian, K.

M. (2016). Tideglusib induces apoptosis in human neuroblastoma IMR32 cells, provoking sub-

G0/G1 accumulation and ROS generation. Environmental toxicology and pharmacology, 46,

194-205.

39. Ramalingam, V., Varunkumar, K., Ravikumar, V., & Rajaram, R. (2016). Development of

glycolipid biosurfactant for inducing apoptosis in HeLa cells. RSC Advances, 6(68), 64087-

64096.

40. Gunasekaran VP, Nishi K, Ravikumar V and Mathan G. Nuclear shuttling of Y-box binding

protein 1, its clinical relevance to cancer and as a therapeutic target. Bangladesh J Pharmacol,

11: 501-24.

41. Marine steroid derived from Acropora formosa enhances mitochondrial- mediated apoptosis in

non- small cell lung cancer cells. Ramalingam Vaikundamooorthy, Revathidevi Sundramoorthy,

Varunkumar Krishnamoorthy, Ravikumar Vilwanathan, Rajaram Rajendran. Tumor Biol, DOI

10.1007/s13277-016-4947-8, 2016.

42. Renu Sankar, Kanchi Subramanian Shivashangari, Vilwanathan Ravikumar. Integrated poly-

D,L-lactide-co-glycolide/silver nanocomposite: synthesis, characterization and wound healing

potential in Wistar Albino rats. RSC Advances.2016.

43. Sridharan Jeyamohan, Rajesh Kannan Moorthy, Mahesh Kumar Kannan, Antony Joseph

Velanganni Arockiam (2016). Parthenolide induces apoptosis and autophagy through the

suppression of PI3K/Akt signaling pathway in cervical cancer. Biotechnol. Lett. 38(8):1251-

1260.

44. Vijayakumar, R., &Nachiappan, V. (2017). Cassia auriculata flower extract attenuates

hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol

metabolism. Biomedicine & Pharmacotherapy, 95, 394-401.

45. Rajendran, V., Krishnegowda, A., &Nachiappan, V. (2017). Antihyperlipidemic activity of

Cassia auriculata flower extract in oleic acid induced hyperlipidemia in Saccharomyces

cerevisiae. Journal of food science and technology, 54(9), 2965-2972.

46. Divya, D., Arul Salomee, K. R., Anusuyadevi, M., Jayachandran, K. S.. "HMGB1: A

Therapeutic Target for Myocardial Infarction." Cardiovasc Ther 7, no. 5 (2017): 555724.

47. Periyasamy, S., Sathya, M., Karthick, C., Kandasamy, M., Shanmugaapriya, S., Tamilselvan, J.,

Jayachandran, K. S., Anusuyadevi, M. Association studies of specific Cholesterol related genes

(APOE, LPL, and CETP) with Lipid profile and memory function: A correlative study among

Rural and Tribal Population of Dharmapuri District, India. J Alzheimers Dis. 2017 (doi:

10.3233/JAD-170272).

48. Velusamy, T., Panneerselvam, S. A., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S.,

Essa, M. M., Guillemin, J. G., Kandasamy, M. Protective effects of antioxidants on neuronal

dysfunction and plasticity in Huntington’s disease. Oxidative medicine and cellular longevity,

2017.

49. Sankar, R., Rahman, P. K., Varunkumar, K., Anusha, C., Kalaiarasi, A., Shivashangari, K. S.,

&Ravikumar, V. (2017). Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applications. Journal of Molecular Structure, 1129, 8-16.

50. Theodore Lemuel Mathuram, Vilwanathan Ravikumar, Lisa M. Reece, Changam Sheela

Sasikumar, Kotturathu Mammen Cherian (2017). Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. Journal of Environmental Pathology, Toxicology and Oncology, 36(4):321–344.

51. Gnanasekar, Sathishkumar, Jeyaraj Murugaraj, Balakrishnan Dhivyabharathi, Varunkumar

Krishnamoorthy, Pradeep K. Jha, Prabukumar Seetharaman, Ravikumar Vilwanathan, and

Sivaramakrishnan Sivaperumal. (2017) "Antibacterial and cytotoxicity effects of biogenic

palladium nanoparticles synthesized using fruit extract of Couroupita guianensis Aubl." Journal

of Applied Biomedicine, 16(1), 59-65.

52. Anusha, C., Sankar, R., Varunkumar, K., Sivasindhuja, G., &Ravikumar, V. (2017). Fourier

transform-infrared spectroscopy as a diagnostic tool for mosquito coil smoke inhalation toxicity

in Swiss Albino mice. Journal of Molecular Structure, 1149, 128-135.

53. Chidambaram, A., Sekar, A., Kavya, S. H., Chidambaram, R. K., Arunachalam, K.,

Senthilkumar, G. P., &Vilwanathan, R. (2017). Synthesis, characterization, and evaluation of

Cd [L-proline] 2, a novel histone deacetylase inhibitor that induces epigenetic modification of

histone deacetylase isoforms in A549 cells. Investigational new drugs, 35(6), 691-705.

54. Thangavel Kavinkumar, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Sellaperumal

Manivannan. Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle

composites. Journal of Colloid and Interface Science; 2017, 505, 1125-1133.

55. Ganesan Nithya, Umapathy Devan, Kannan Mahesh Kumar, Arockiam Antony Joseph

Velanganni (2017). A review on the role of Astrocyte Elevated Gene-1 in cancer. Int J Phar Sci

and Res. 8(3): 975-984.

56. Moorthy Rajesh Kannan, Jeyamohan Sridharan, Nagapoosanam Anantha Lakshmi, Arockiam

Antony Joseph Velanganni (2017). Identification and characterization of evolutionary

conserved miRNAs in various types of cancer: in silico and experimental approach. RJLBPCS

3(4): 70-89.

57. Karthick C, Nithiyanandan S, Essa MM, Guillemin GJ, Jayachandran SK, Anusuyadevi M.

Time-dependent effect of oligomeric amyloid-β (1-42)-induced hippocampal neurodegeneration

in rat model of Alzheimer's disease. Neurol Res. 2018 Nov 19:1-12. doi:

10.1080/01616412.2018.1544745.

58. Divya Dasagrandhi, Arul Salomee Kamalabai R, Anusuyadevi Muthuswamy, Angela Marie

Lennox ,Tamilselvan Jayavelu, Vasudharani Devanathan, Jayachandran Kesavan Swaminathan.

Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial

damage in cardiovascular complications. Biomedicine & Pharmacotherapy 20, February 2018.

59. Sathya, M., Gobinath, T., Salomy, A., Nisha, M., Kandasamy, M., Essa, M. M., Jayachandran,

K. S., Anusuyadevi, M. Biophysical interaction of resveratrol with sirtuin pathway:

Significance in Alzheimer’s disease. Frontiers In Bioscience, Landmark, 23, 1380-1390, March

1, 2018.

60. Pattarayan, D., Thimmulappa, R. K., Ravikumar, V., & Rajasekaran, S. (2018). Diagnostic

potential of extracellular microRNA in respiratory diseases. Clinical reviews in allergy &

immunology, 54(3), 480-492.

61. Ramalingam, V., Varunkumar, K., Ravikumar, V., & Rajaram, R. (2018). p53 mediated

transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers

intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions, 287, 1-12.

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