Denmark International symposium - AlgeCenter Danmark · Inclusive courtesy of Ian Rowland,...
19
Transcript of Denmark International symposium - AlgeCenter Danmark · Inclusive courtesy of Ian Rowland,...
From berries to seaweeds?
Plants = Sessile Well developed
secondary metabolism
Polyphenols
Edible
Inclusive courtesy of Gordon Mc Dougall, The Hutton Institute
Antioxidant capacity
Seaweed TEAC value*
A.
nodosum
9.18
P. palmata 9.08
A.
esculenta
9.79
Raspberry
(Glen
Ample)
8.16
All seaweeds yield similar but appreciable antioxidant capacity expressed per mg phenol content. All seaweeds
have higher antioxidant potential than raspberry.
Inclusive courtesy of Gordon Mc Dougall, The Hutton Institute
• seaweed polyphenols possess anti-
proliferative activity and an antidiabetic
effect (Nwosu 2011)
• •phlorotannins found mainly in brown
seaweeds are potent anti-inflammatory
substances (Khan 2008)
Inclusive courtesy of Gordon Mc Dougall, The Hutton Institute
Anti-cancer effects
Proliferation of colon cancer (Caco-2) cells was reduced by seaweed polyphenols
Alaria esculenta polyphenols (Wakame) were the most effective with a IC50 value of < 10 mg/ml – possibly related to their higher antioxidant potential
A. nodosum & P. palmata extracts gave IC50 values of 33 & 38 mg/ml resp.
0
10
20
30
40
50
60
70
80
90
100
110
0 10 20 30 40 50
Phenol content (mg/ml)
% C
on
tro
l
Nwosu et al. Food Chemistry 126 (2011) 1006–1012
Inclusive courtesy of Gordon Mc Dougall, The Hutton Institute
14
Phlorotannins Phenolic acids
Catechins Tannins
Flavonoids
Polyphenols in seaweeds –
up to 15% dry weight
Inclusive courtesy of Ian Rowland, University of Reading, UK
Plant-Derived Phenolics
15
OH
OH
OH
Stilbenes
(Wine, nuts)
OH
CH2OH
CH2OH
OH
OMe
MeO
Lignans, ferulic acid,
isoflavones
(seeds, cereals. legumes)
Phenolic acids
(Citrus fruits, coffee)
O
OH
OH
OH
OH
HO
Flavonoids
(Fruit, veg.)
Catechins, tannins
(tea)
Inclusive courtesy of Ian Rowland, University of Reading, UK
16
Antioxidant effects
Signalling Pathway Modulation
Cell Growth and Differentiation Gene Expression
Inhibitors of inflammation
Potential Actions of Plant
Bioactives in the body
Inclusive courtesy of Ian Rowland, University of Reading, UK
Human intervention studies
• University of Ulster Colraine, N. Ireland
• NICHE dedicated to carrying out nutritional
intervention trials on human volunteers
• --one of the top nutrition research centre
in Europe
• State of the art human intervention studies
unit (HISU)
