Delivering Valued Genomic Products to Livestock Customers DeNise_PPT.pdf · What We Do A leader in...
Transcript of Delivering Valued Genomic Products to Livestock Customers DeNise_PPT.pdf · What We Do A leader in...
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Delivering Valued Genomic Products to Livestock Customers
Sue DeNise, Ph.D. Sr. Director, Global Genetics R&D
Veterinary Medicine Research and Development
Predict The Future Now!
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Who We Are u A Pfizer business
u A leading global animal health company
u Working to assure a safe, sustainable global food supply from healthy beef and dairy cattle, swine, poultry, sheep and fish
u Helping dogs, cats and horses live healthier longer lives
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What We Do
A leader in discovery, development, and manufacture of veterinary vaccines & medicines
5000+ colleagues worldwide including 800+ veterinary R&D scientists and specialists
Diverse portfolio of leading veterinary products & services for livestock & companion animals
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Melbourne Australia
Mumbai (Thane) India
Bri=sh Columbia Canada
Kansas City Missouri
Lincoln Nebraska
Charles City Iowa
College Park Maryland
Kalamazoo Michigan
Louvain-la-Neuve Belgium
Zaventem Belgium
Olot Spain
Lyon France
Sao Paolo Brazil
Shanghai China
New Delhi India
PAH Global R&D Network – Genetics Businesses
Genetics Business Locations
Dunedin New Zealand
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PAH Leads Industry in Global R&D Investment
Pfizer Merck Merial Elanco, Janssen
Bayer BIVI Novartis CEVA Virbac Vétoquinol
30M 48M 56M
115M 122M 127M 166M
206M 240M
Sources: Pfizer Animal Health actual 2010 R&D spend. Vetnosis July 29, 2011 Income Statement Report of 2010 R&D spend for other animal health companies.
R&D Spend (in $Millions) PAH R&D
$321 million Strategic Investments Include: ü Animal Gene=cs ü Diagnos=cs ü Emerging Infec=ous Diseases
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Why Genetics – The Challenge
Source: Food Economics and Consumer Choice (Simmons, 2008)
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CONFIDENTIAL
Genomic Tools for Dairy Cattle
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U.S Holstein Gene0c Trend – Sires and Elite Dams
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Units of T
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AIPL Bull PTA AIPL Cow PTA
Gene=c Gap
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What is CLARIFIDE® for Dairy? A Portfolio of Predictions and Tools to Implement Genetic Improvement of Commercial Dairy Females
• A panel of 6,900 (LD) and 50,000 (50K) genetic markers – USDA Animal Improvement Programs Laboratory (AIPL) – Derived from 54,001 (50K) marker panel test
• Delivers genomic predictions for: – Holstein, Jersey, and Brown Swiss – 30 production, health and type traits – 9 composite indexes
• Includes markers to: – Authenticate parentage – Bolster reliability of genetic predictions – Help manage inbreeding
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CLARIFIDE® Empowers Female Selection
Based on CLARIFIDE in Holstein Cattle. Pfizer Animal Genetics, Data on File
0 10 20 30 40 50 60 70 80
NM$ PL SCS DPR Milk Fat Prot
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Parent Avg Reliability CLARIFIDE 6K Reliability
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What’s a SNP Genotype Worth?
For the protein yield (h2=0.30), the SNP genotype provides information equivalent to an additional 34 daughters
Pedigree is equivalent to information on about 7 daughters
John Cole: aipl.arsusda.gov/publish/presentations/.../NCSU_2012_jbc.pptx
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And for daughter pregnancy rate (h2=0.04), SNP = 131 daughters What’s a SNP Genotype Worth?
John Cole: aipl.arsusda.gov/publish/presentations/.../NCSU_2012_jbc.pptx
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Genomic Predictions Upper Midwest Dairy (n=240)
Based on CLARIFIDE in Holstein Cattle. Pfizer Animal Genetics, Data on File
R² = 0.2673 Correlation = 0.52
15.000 17.000 19.000 21.000 23.000 25.000 27.000 29.000 31.000 33.000 35.000 37.000 39.000 41.000 43.000 45.000 47.000
-1.500 -1.250 -1.000 -750 -500 -250 0 250 500 750 1.000 1.250 1.500 1.750
Act
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ilk P
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CLARIFIDE Milk Genomic Prediction Based on AIPL Predictions (DGV April 2011)
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CONFIDENTIAL
Strategies for Accelerating the Female Genetic Improvement
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Real World Example: Strategic Breeding
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• California Dairy Customer is using sexed semen in beJer heifers to improve quality of future female progeny
• Strategic alloca0on of sexed semen in top 50% of gPTA heifers for Net Merit $
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• Future progeny of California Dairy will increased genetic progress 134% or $ 224 Net Merit in the next heifer generation
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Real World Example: Strategic Breeding
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Dairy Solutions Provider
Gene=cs
Health
Milk Quality
Reproduc=on
Nutri=on Ø Comprehensive porZolio of products and services
Ø Deliver solu0ons for technical business challenges
Ø Strive to earn a place in dairy management teams
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CONFIDENTIAL
Partnering to Deliver Genomic Products
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American Angus Assoc. ANCP Red Angus Assoc NAPCo Ovita
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Traits – GE-EPDs & Ranks
• Calving Ease Direct • Birth Weight • Weaning Weight • Yearling Weight • Dry Matter Intake (RADG) • Residual Feed Intake • Yearling Height • Scrotal Circumference • Docility • Calving Ease Maternal • Milking Ability • Mature Weight • Mature Height • Carcass Weight • Fat Thickness • Ribeye Area • Marbling Score • Tenderness
Parentage – HD 50K Features of HD 50K for Angus
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HD 50K Information is Integrated into EPDs, Indexes and Accuracy Values
Lot 1 Pfizer Example Reg. No: Tattoo:
GE-‐EPDs simplify selec0on, ma0ng and marke0ng because all available data is integrated, removing the need to consider
individual sources of trait informa0on.
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Trait Average
Change in EPD from HD 50K1
Average Change in Accuracy with HD 50K
from .052 Accuracy
Approximate Progeny
Equivalents
CED ±1.6 units .24 14
BW ±.45 lb .25 8
WW ±2.2 lbs .23 16
YW ±3.1 lbs .27 20
RADG ±.03 lbs/day .27 13
YH ±.10 in .29 8
SC ±.12 cm .30 9
Doc ±2.9 units .25 8
Milk ±1.2 lbs .15 12
MW ±14 lbs .29 7
CW ±4.1 lbs .17 7
Marb ±.08 units .24 12
RE ±.10 in2 .23 9
FAT ±.01 in .23 11
1Derived from animals with ≤ .30 accuracy. 2Accuracy from pedigree only
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Acquiring Technology • Sponsored Research
– Academic Ins0tu0ons – CSIRO
• License Technology – Ovita – Australian CSIRO – Gene0c Condi0ons
• Internal R&D – Nelore predic0ons – Global Angus predic0ons
• Collabora0ve research – Angus Gene0c, Inc. – Large Pastoral Companies
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R&D Pipeline Decisions “Customer focused”
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v Can we use synergies to develop complete solutions for our customer’s challenges? v Health Traits v Diagnostic tools to refine
genomics v Rational use of Pharma/
biopharma products
Integrated Solutions Path Forward
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CONFIDENTIAL 24