December 2018 | Volume 3 | Issue 1 - hsc.ghs.org · GHS Proc. December 2018; 3 (1) 3 December 2018...

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December 2018 | Volume 3 | Issue 1 | ISSN 2475-837X (print) | ISSN 2475-8434 (online) Clemson University Nursing building, Greenville, SC

Transcript of December 2018 | Volume 3 | Issue 1 - hsc.ghs.org · GHS Proc. December 2018; 3 (1) 3 December 2018...

Page 1: December 2018 | Volume 3 | Issue 1 - hsc.ghs.org · GHS Proc. December 2018; 3 (1) 3 December 2018 Greenville Health System Proceedings (GHS Proceedings) is a peer-reviewed medical

December 2018 | Volume 3 | Issue 1

| ISSN 2475-837X (print) | ISSN 2475-8434 (online)

Clemson University Nursing building, Greenville, SC

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Greenville Health System and Palmetto Health are becoming

PrismaHealth.org

Why Prisma Health?

Since we launched our new health organization last November, we have made great progress by building on the

strength and legacies of Greenville Health System and Palmetto Health. Together, we are looking at health in a

completely new way.

In early 2019, we will unite under one name, one logo and one way of delivering health care.

Because the name Prisma Health is unique, we can make it our own. Our bold, fresh visual identity includes sharp

angles and bright, vibrant colors that distinguish us from traditional health care providers in our region. The design

of the letters is intentional and engaging, evoking the facets of a prism. The name and logo reflect the multifaceted,

dynamic organization we are today, and light the way for all we are becoming.

What stays the same?

We will continue to honor the sacred relationships our patients and their families have with their physicians and

advanced practice providers. Your doctor won’t change. Your hospital won’t change. Your physician practice will

stay the same, too. Only our company names and logos will change to reflect our new unified organization.

We continue to be dedicated to transforming health care through education and clinical research. Collaborating

with our academic partners, we are teaching the next generation of physicians, nurses, dentists and other medical

professionals, and investing in research to improve the lives of those we serve.

And we continue our commitment to keep health care local. By coming together as one, we’re shaping our own

future so we may continue to improve the health of all South Carolinians.

What’s our promise?

Inspire health. Serve with compassion. Be the difference.

Our 30,000 team members are dedicated to supporting the health and well-being of you and your family. To learn

more about how we will serve you, visit PrismaHealth.org.

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3GHS Proc. December 2018; 3 (1)

December 2018

Greenville Health System Proceedings (GHS Proceedings) is a peer-reviewed medical journal that represents the top academic and clinical research activities happening at GHS and throughout the world. GHS Proceedings is published twice a year (spring and fall) and is a primarily online journal consisting of original research, review articles, case reports, editorials, book reviews, and more. GHS Proceedings’ mission is to provide high-quality publications on health care innovation and delivery (university.GHS.org/Proceedings).

All statements and opinions expressed in GHS Proceedings are those of the authors and not necessarily those of Greenville Health System, its board of trustees, or any of its affiliates.

To receive upcoming issues by email, contact GHS Proceedings at [email protected].

Copyright © 2018 Greenville Health System. All rights reserved.

The peer-reviewed journal of Greenville Health System

Vision: To transform health care through the publication of relevant, innovative, and multidisciplinary scholarship concerning advancements in clinical, academic, and translational research

Editor-in-Chief: William D. Bolton, MD ([email protected])

Managing Editor: Jerry Salley, BA ([email protected])

Associate Editors: A. Michael Devane, MD; David P. Schammel, MD; Jeffrey W. Elder, MD; Timothy P. McHenry, MD; Naveen N. Parti, MD; Jeremy A. Warren, MD

Editorial Board: Irfan M. Asif, MD; Jagannadha R. Avasarla, MD, PhD; Molly Benedum, MD; Susan Bethel, MSN, RN, NE-BC; Parampal Bhullar, MD; Matthew D. Bitner, MD, MEd, FACEP; Eric S. Bour, MD, MBA, FACS, FASMBS; John S. Bruch, MD, FACE; Nichole Bryant, MD; Christopher Campen, PharmD, BCOP; Joni Canter, MBA, ATC; Christopher G. Carsten III, MD; Anna L. Cass, PhD, MPH; India Chandler, MD; Catherine M. Chang, MD; F. Tich Changamire, MD, ScD, MBA; Patricia L. Cheek, MD; John D. Cull, MD; Patrick J. Culumovic, MD; James R. Davis, MD; Lauren D. Demosthenes, MD; Kacey Y. Eichelberger, MD; M. Carmela Epright, PhD; J. Alex Ewing, MS; Sarah R. Farris, MD; Lawrence D. Fredendall, PhD; Sagar S. Gandhi, MD; Bruce H. Gray, DO; Steven B. Holsten Jr, MD, FACS; William W. Hope, MD, FACS; Matthew F. Hudson, PhD; J. Terrill Huggins, MD; Sandip Jain, MD; Lindsay H. Jones, CRNA; J. William Kelly, MD; Laura H. Leduc, MD; Bruce A. Lessey, MD, PhD; Ervin L. Lowther, MD; Charles G. Marguet, MD; Nancy Markle, RN ; Brian P. McKinley, MD, FACS; Paul B. Miller, MD; Ryan Miller, Sr Embryologist; Benjie B. Mills, MD; S. John Millon, MD; Ivaylo I. Mitsiev, MD; Bryan S. Moon, MD; John S. Morris, MD; Phillip Moschella, MD, PhD ; Bryce A. Nelson, MD, PhD; M. Jason Palmer, MD; Puraj Patel, DO; Nirav T. Patil, MBBS, MPH; Sarah B. Payne-Poff, MD; Larry E. Puls, MD; Krista Ramirez, PharmD, BCPS; Vinayak S. Rohan, MD; Robert A. Saul, MD; Kerry K. Sease, MD, MPH; Rhett M. Shirley, MD; Dane E. Smith, MD; John A. Spratt, MD; Antine E. Stenbit, MD, PhD; Michael Stewart, MD; Jeremy Stuart, PhD, MPH; Laurie M. Theriot Roley, MD; Steven D. Trocha, MD; Adam B. Tyson, MD; John Van Deman III, MD; Diana Vargas Vives, MD; David J. Walsh, MD; Thomas L. Wheeler, MD; Michael W. Wiederman, PhD; Christopher C. Wright, MD; Steven L. Young, MD; Yuliya Yurko, MD

Editorial Services: Jeanine Halva-Neubauer, MA; Jerry Salley, BA

Produced By: GHS Creative Services

Volume 3 | Issue 1

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4 GHS Proc. December 2018; 3 (1)

Table of ContentsSpecial Articles5 A Selection of Abstracts Presented at the 2018 GHS Health Sciences Center Research Showcase

23 Full List of Abstracts Presented at the 2018 GHS Health Sciences Center Research Showcase

Miscellany29 2018 Greenville Health System Residents and Fellows

30 2018 Graduates of Greenville Health System and University of South Carolina School of Medicine Greenville

31 Publications and Abstracts of Greenville Health System Medical and Scientific Staff, July 2017-June 2018

About the 2018 Research ShowcaseThe 2nd Annual Research Showcase, presented by GHS Health Sciences Division of Research and Scholarship, took place April 13 at GHS Greenville Memorial Hospital. This event promotes trans-lational research activities and collaborative work with the system and its three primary academic partners: Clemson University, Furman University, and the University of South Carolina. More than 75 posters were accepted for display. Awards were presented in several categories, which can be found on Page 23.

Guidelines for authors are available at university.ghs.org/proceedings/authors. Completed manuscripts may be submitted online (university.ghs.org/proceedings/submit) or emailed to [email protected].

On the CoverClemson University Nursing building opened August 2018 on Greenville Memorial Medical Campus. In the foreground is the building’s connector to University of South Carolina School of Medicine Greenville.

Photo by Kris Decker/Firewater Photography

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Special Article

Factors Affecting Salvage Rate of Infected Prosthetic MeshHamza Abbad, Benjamin Hancock, William Cobb, Alfredo Carbonell, and Jeremy Warren

Prosthetic mesh infection (PMI) is a challenging complication after ventral hernia repair (VHR). No clear optimal treatment strategy exists, leaving only experience and judgment to guide surgical decision making.

Retrospective review of patients with PMI was performed. Subsequent abdominal operation (SAO) constitutes any intra-abdominal operation occurring after the index hernia repair prior to PMI pre-sentation. Any mesh removal was considered salvage failure. Analysis was performed using Chi-square test, Fisher’s exact test, or Mann-Whitney U test.

We identified 165 instances of PMI. Most cases (60%) involved intraperitoneal mesh. Thirty-eight percent of patients had an SAO, 64.1% of which were CDC wound class 2, 3, or 4; 67.2% involved intraperitoneal mesh. Enteroprosthetic fistula was found in 15.2% of cases. Mean time to presenta-tion was 17 months after index hernia repair or SAO for infection alone and 54 months when a fistula was present (P = .015).

Macroporous polypropylene mesh was salvaged in 66.7% of cases overall and 72.7% when posi-tioned in an extraperitoneal space. Mesh salvage was not possible in any case involving composite or PTFE mesh and rarely for microporous polypropylene (7.7%), multifilament polyester (5.9%), or intraperitoneal mesh (6.1%). Closure of the defect after mesh removal, with or without component separation or mesh reinforcement, significantly lowers recurrence rate (P < .001).

PMI involving composite, PTFE, multifilament polyester, or microporous polypropylene mesh re-quires explantation. Infected macroporous polypropylene mesh in an extraperitoneal position is sal-vageable in most cases. Risk of secondary mesh infection after SAO, particularly with intraperitoneal mesh, should be considered during index VHR.

Volumetric Analysis of Patients Undergoing Abdominal Wall Reconstruction After Preoperative Progressive PneumoperitoneumJohn Allen, Jeremy Warren, and Joseph Bittle

Introduction: Preoperative progressive pneumoperitoneum (PPP) is a method of increasing abdomi-nal cavity volume prior to repair of massive incisional hernias with loss of abdominal domain (LOD). We hypothesize that the increase in abdominal cavity volume after PPP is adequate to accommo-date the initial hernia contents.

Methods: Retrospective review of all PPP patients over a 10-year period was performed. Volumetric analysis was conducted before and after PPP as described previously. The accommodating volume (AV) was defined as the abdominal cavity volume (ACV) – (pre-PPP ACV + pre-PPP hernia sac vol-ume). Primary outcomes were AV, change in length, and abdominal wall musculature. Secondary out-comes were length of stay, surgical site occurrence, surgical site infection, recurrence, and readmission.

Results: Twenty-nine patients underwent PPP. Mean hernia width was 18.6 cm, with an ACV:HSV ratio of 40%. Mean time of PPP was 7.7 days. Mean increase of ACV after PPP was 3.3 L with

A Selection of Abstracts Presented at the 2018 GHS Health Sciences Center Research Showcase

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mean AV of 0.37 L. All repairs were open with the majority having mesh in retromuscular position (75.9%). Average increase in oblique muscle complex length and rectus muscle width was 2.57 cm and 1.04 cm, respectively.

Fascial closure was achieved in 65.5% of cases. The AV significantly impacted fascial closure, with a mean AV of 1.1 L when fascial closure was achieved and -1.6 L when closure was not achieved. Sim-ilarly, increasing hernia width impacted closure, with a mean width of 24.2 cm in those unable to be closed and 15.6 cm when closure was possible. Complications included SSO in 48% of patients, SSI in 27.6%, and SSO requiring intervention in 71.4%. Recurrence was 24.1% with mean 26.7-month follow-up.

Conclusion: Patients with loss of domain benefit from PPP by increasing ACV and lengthening abdom-inal wall musculature to accommodate initial herniated contents. Greater hernia width, ACV:HSV, and AV predict ability to close fascia.

Assessing Barriers to Implementing Shared Decision MakingAlexa Bianchi, Brittany Crum, and Meenu Jindal

Shared decision making (SDM) is a highly valued method of patient-centered care, but extensive studies show a surprisingly lower rate of implementation than expected with such an effective model. We are curious about what is preventing physicians from interacting with their patients using a SDM approach specifically at our internal medicine clinic at Greenville Memorial Hospital (GMH).

Internal medicine residents at GMH were invited to fill out a presurvey that subtly assessed their knowledge of SDM. Residents then listened to a lecture on SDM and took a posttest to reassess their actual implementation of SDM and perceived barriers to implementing this type of patient-physician interaction.

Residents were found to highly value SDM but did not implement it as much as expected. They reported time, patient education, and lack of efficient decision-making aids as the biggest barriers to implementing SDM.

With these barriers defined, our next step is to create a shared decision-making aid for one of the more difficult and time-consuming physician-patient discussions we see in our clinic: colonosco-pies. The interactive in-office decision aid will easily outline the disease, risks, benefits, procedure, and other pertinent aspects of colonoscopies so that the patient can read and formulate questions before seeing the physician. Our intention is to save time and increase patients’ understanding and investment in their health.

The global impact on health will benefit patients in low health literacy populations who can begin to understand more about their health, leading to increased patient adherence, enhanced patient-phy-sician rapport, and decreased medical costs.

Early Warning Response System in GHS School-Based Health Centers: Connecting Students to Mental Health Care and Social SupportsHolly Bryan, Laura Rolke, Sarah Griffin, Jacqueline Forrester, Laura Johnson, and Kerry Sease

Greenville Health System (GHS) has partnered with the United Way to establish 4 School-Based Health Centers (SBHCs) in high-poverty neighborhoods. SBHCs provide a unique opportunity to reach adolescents in an accessible setting.

High-risk students are identified through the Early Warning Response System (EWRS). EWRS is a real-time data dashboard that monitors attendance, behavior, and grades. Each EWRS student is recommended to be referred for a SBHC appointment. A comprehensive assessment (eg, HEADSS, PHQ2) is completed to determine well-being and screen for risks associated with social determi-nants of health. While the SBHCs do treat acute illness and manage chronic conditions, the service

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

targets students at highest risk for dropping out to better understand what is happening in their lives socially and emotionally.

The purpose of this study was to identify how many SBHC visits were completed by EWRS students, the number of screenings, and the result of these screenings. Chart abstraction and analysis revealed 784 SBHC visits during the 2016-2017 school year, 20% of which were EWRS referrals. A total of 94% were provided a screening, and 88% revealed complicated physical, emotional, behavioral, or social health concerns. Students were connected to services (eg, insurance) and outside care (eg, medical homes and specialists). Of all students seen by the SBHC, 94% were able to return to class.

SBHCs are able to help those students most at risk of dropping out and intervene to more effective-ly address the underlying issues contributing to presenting physical ailments, poor school perfor-mance, and behavior.

Beyond Bates: Advanced Physical Exam Series for Medical StudentsRyan Dean and Steven Connelly

Purpose: To develop a curriculum for medical students that teaches proper technique and choice of both routine and advanced physical exam maneuvers as they relate to medical decision making in clinical practice.

Methods: A 2-week pilot course was created in partnership with the University of South Carolina School of Medicine Greenville. JAMA Rational Clinical Examination and the Evidence-Based Phys-ical Diagnoses were used to develop the curriculum focusing on various topics relevant to internal medicine. Both faculty and residents assisted in leading the course.

Results: Five fourth-year medical students enrolled in the pilot course. A 21-question precourse as-sessment and a 20-question postcourse assessment were administered.

Precourse average: 12.4/21 points (59.1 ± 12.9%). Postcourse average: 16.8/20 points (84.0 ± 11.4%).

All students demonstrated an improvement in their percent score by 25 ± 10.6%. An oral final as-sessment was developed with 4 clinical scenarios using the Greenville HealthCare Simulation Cen-ter. Grading was based on five clinical categories.

Average oral score: 34.8 out of 40 points (87 ± 8.9%).

Students provided feedback explaining that the afternoon physical exam rounds were most helpful for learning. Students requested more structured teaching on maneuver technique.

Conclusion: After participating in the pilot course, students demonstrated improved knowledge and implementation of the physical exam for clinical decision making and cost-effective care. Results from the pilot will be used to improve a follow-up course that has already been expanded to include 8 students.

Antibiotic Irrigation of the Surgical Site Decreases Incidence of Surgical Site Infection After Open Ventral Hernia RepairLily Fatula, Allison Foster, Hamza Abbad, Joseph Ewing, Ben Hancock, William Cobb, Alfredo Carbonell, and Jeremy Warren

Purpose: Antibiotic lavage of the surgical field before abdominal wall closure has been shown to lower the incidence of both intra-abdominal and soft-tissue SSI. We hypothesize this combination decreases incidence of surgical site infection (SSI) after open ventral hernia repair (OVHR).

Methods: Retrospective review of OVHR with mesh at a single high-volume center (Greenville Health System Hernia Center) from 2008-2017 was performed. All patients were repaired in an open fashion with mesh, primarily in the retromuscular space. Three groups were identified: (1) patients receiving no antibiotic irrigation (Group 1); (2) gentamicin (G) alone (Group 2); or (3) G + clindamycin (C) irrigation (Group 3). Analysis was completed using Chi-square or Fisher’s exact test

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(for n <5), ANOVA, or Kruskal-Wallis test, and, finally, logistic regression to determine the effects of irrigation on SSI.

Results: We identified 852 patients undergoing OVHR. No irrigation was used in 260 patients, G alone was used in 266 patients, and G + C was used in 299 patients; 27 patients were excluded because of different antibiotic regimens. Incidence of SSI was also significantly lower after G + C irrigation, but not G alone (Group 1, 16.5%; Group 2, 15.4%; Group 3, 5.0%; P < .001).

Multivariate logistic regression demonstrated significantly increased SSI with contaminated wounds (OR 4; 95% CI 2.0-8.2), dirty wounds (OR 6.3; 95% CI 2.9-13.4), and COPD (OR 4.1; 95% CI 2.4-6.9), as expected. Use of G + C was an independent predictor of decreased SSI (OR 0.29; 95% CI 0.14-0.58).

Conclusion: Irrigation with a combined G + C antibiotic irrigation significantly reduces the incidence of SSI following OVHR with mesh.

Geographic Variation in the Treatment of Proximal Humerus Fracture in the Medicare PopulationSarah Floyd, Joel Campbell, Charles Thigpen, Mike Kissenberth, and John Brooks

Purpose: Conservative management has become the preferred initial course of treatment for pa-tients with proximal humerus fracture (PHF); however, surgical management rates vary widely across the country. The objective of our study was to evaluate local area treatment variation in managing acute PHF.

Methods: This was a retrospective cohort study of Medicare patients diagnosed with PHF in 2011. Patients receiving reverse shoulder arthroplasty, hemiarthroplasty, or open reduction internal fixa-tion within 60 days of their PHF diagnosis were classified as surgical management patients. Area treatment ratios at the hospital referral region (HRR) level were calculated as the ratio of the number of patients in the HRR who received surgical treatment over the sum across these patients of their predicted probabilities of receiving surgical treatment.

Results and Summary: Among patients with PHF (N = 77 053), 15.0% received surgery and 85.0% received conservative management. Patients who were older, had more medical comorbidities, were male, nonwhite, or dual-eligible for Medicaid were less likely to receive surgery (P < .0001).

Surgery rates varied from 6.3% to 25.6% across all HRRs, with variation in South Carolina ranging from 11.5% to 21.2%.

Applicability to Health Care: Given the heterogeneity of treatment effects, it is possible that variation in surgery rates may represent appropriate care in local areas. Alternatively, higher surgery rates may reflect an overuse of surgical treatment that does not result in improved outcomes for patients. Future analysis will assess the association between higher surgical rates and patient outcomes such as mortality and Medicare spending.

Persistent Functional Neurological Symptom Disorder Spontaneously Remits With ECT TreatmentRaphaela Fontana, Frank Clark, and Benjamin Griffeth

Background: A 49-year-old Caucasian female has had 3 psychiatric hospitalizations over a 2-year time period since a complicated cardiac ablation that resulted in the patient needing defibrillation for nonsustained ventricular tachycardia. Family and patient both endorse alterations in her mood and emergence of a new debilitating tremor after being told about the cardiac arrest requiring lifesaving measures.

Initially, this patient was treated with psychotropic medications during her first hospitalization, which improved her depression, but not her functional tremor. Approximately 1 year later, she had

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

2 recurrent hospitalizations for acute decompensation with catatonia and significant tremor within a 2-month span. At that time, the patient’s medical workup and imaging were largely within normal limits or found to be unremarkable.

The patient’s catatonic presentation and functional motor tremor resolved with concurrent psy-chotropic medications (Remeron 30 mg QD, Propanolol 10 mg TID, Zoloft 200 mg QD, Risperdal 1 mg QHS, Ativan 0.5 mg TID), and electroconvulsive therapy (ECT) during both hospitalizations. A paucity of evidence exists demonstrating the remission of conversion disorder with a multimodal therapeutic approach of ECT and psychotropic medications. This case presentation will investigate the potential use of ECT in treating functional tremor/conversion disorder in a patient with underly-ing refractory depression.

Objectives: Present a case in which a proposed relationship can be shown between a traumatic event and new-onset conversion disorder. Propose and explore a new treatment modality with ECT for a patient with refractory or treatment-resistant depression and concurrent conversion disorder.

Optimization of Automated Guided Vehicle System in Health Care FacilityKade Gilstrap, Amogh Bhosekar, Tugce Isik, Sandra D. Eksioglu, and Robert Allen

Background: Automation in material handling systems has been a key to promoting cost-effective ma-terial flow within health care facilities. This research analyzes Automated Guided Vehicles (AGV) use in a hospital. AGVs perform tasks such as moving surgical instruments, drugs, linen, food, and trash. Use of AGVs has improved staff utilization; however, it has also increased traffic and congestion.

Purpose: The goal of this study is to evaluate the impact of AGV use in the hospital.

Methods: Historical data about travel time for all AGV trips at different times of the day and days of the week have been analyzed.

Results: A Pareto analysis indicated that the majority of AGV travel time is spent in 3 trips. A statisti-cal analysis of these trips demonstrates that the distribution of travel time during peak and off-peak hours is statistically different. The same holds true for travel times during different days of the week. Difference in travel time is the result of congestion.

Conclusion: Based on these results, we believe that reducing the number of AGVs used and imple-menting a Kanban system, which maintains only a fixed number of AGVs active and moving during peak hours, will reduce congestion. This numerical analysis provides the data necessary for develop-ing a simulation model that will identify the right number of AGVs to use in this system at different hours of the day and different days of the week.

Improving Quality to Facilitate ResearchAmanda Goode, Katie Daniels, and Matthew Hudson

Purpose: Federal regulations require that an Institutional Review Board (IRB) review and approve all human subjects research before research initiation. To optimize review efficiency, Greenville Health System’s Office of Human Research Protection (OHRP) revised its policy on adverse event reporting in June 2017. Investigators may now report in aggregate at continuing review all nonserious adverse events that are not unanticipated problems. OHRP examined whether this change reduced the du-ration from submission to IRB approval.

Methods: There were 1318 IRB submissions from January 2017-March 2017 (before policy revision), with 582 submissions from October 2017-December 2017 (after policy revision). OHRP compared summary statistics and performed analyses by review type (full board or expedited) and time period.

Results: Mean and median full-board review durations decreased from 41.08 and 30 days, respec-tively, to 24.43 and 22 days, respectively, subsequent to policy change (U = 6067.5; P < .0001). The mean expedited review duration decreased from 20.75 to 13.37 days, while the median was 12 days for both time periods (U = 234 106.5; P < .0002).

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Discussion: Results suggest that OHRP improved IRB efficiency by changing the adverse event re-porting process. This change could afford our patients more immediate access to clinical trials and provide system leadership with quicker access to care improvement data. Finally, this improvement may also relieve administrative burden for investigators, study coordinators, IRB chairs, and IRB co-ordinators. Collectively, these benefits may facilitate sustained research engagement and enhance IRB resource use.

The Correlation Between Residency Applications and Standardized Behavioral Assessments for Gaining Entry Into a Graduate Medical Education ProgramVincent Green and Ardalan Ahmadi

Purpose: This study’s purpose is to develop a standardized assessment tool for selecting residents into a graduate medical education (GME) program.

Methods: A standardized assessment tool for selecting residents into a GME program was devel-oped by faculty within the Greenville Health System (GHS) Family Medicine Residency. The assess-ment tool consisted of two parts: (1) a preinterview instrument (maximum total score = 28) assess-ing board scores, grades during undergraduate medical education, extracurricular activities, letters of recommendation, interest in family medicine, and scholarly activity; and (2) a rubric of behavioral questions (maximum total score = 16) with standardized anchors for objective assessment within the domains of problem solving, resilience, interpersonal communication and professionalism, and emotional intelligence. The tool was used to assess all applicants who interviewed with the GHS Family Medicine Residency during recruitment for the class beginning July 2018.

Results: Overall, 71 applicants (mean age = 27.1 years; 49.3% male, 50.7% female; 80% Caucasian, 7% African American, 3% Hispanic, 10% other) were selected to interview from October 2017-Janu-ary 2018. The mean preinterview assessment score = 22.73 (range 17-27), behavioral rubric score = 11.46 (range 8-16), and total composite score = 35.4 (range 27-42).

Correlation between the application preinterview assessment and the behavioral rubric measuring interview performance was 37.3%. Low correlations were also found within each individual domain of the preinterview assessment and the behavioral health questions.

Conclusions: Objective tools for selection into GME programs are lacking. Ideal selection criteria include a combination of the candidate’s application and performance during an interview. Data from this investigation suggest little correlation exists between strength of application and interview performance, which highlights the need for measuring both components during the selection of candidates into GME programs.

JUMPing Into Diabetes ControlLauren Hassan, Sheena Henry, Gail Chastain, and Meenu Jindal

Background: A study analyzing the results of the Boston Area Community Health Survey confirmed that socioeconomic status has a stronger association with diabetes prevalence than does race. If systems were in place to address socioeconomic barriers, the inequality in diabetes prevalence and complication rates may improve.

Purpose: The construct of this study (named JUMP as an uplifting, motivating title) is to provide patients who have diabetes with a group setting focusing on self-empowerment.

Methods: Groups included 1 or 2 resident facilitators, a diabetes educator, and 5-10 internal medicine clinic patients. The program included 3 weekly sessions consisting mostly of patient-led discussion. JUMP has graduated 24 participants. As a comparison group, 24 patients were pooled from the list of clinic patients who expressed interest in the program but did not enroll. Patients’ pretest and posttest JUMP HgbA1c levels were measured.

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

Results: JUMP participants showed a statistically significant decrease in HgbA1c. The average pre-JUMP HgbA1c was 9.3 ± 2.5; post-JUMP level was 8.0 ± 1.9. The difference yielded a mean drop in HgbA1c of 1.3 (P < .001). The control group yielded pre-JUMP HgbA1c of 9.0 ± 2.2 and post-JUMP level of 9.2 ± 2.3, a variation with no significant change (P = .418).

Discussion: The United Kingdom Prospective Diabetes Study found that the rate of microvascular complications from diabetes fell by 25% when comparing patients with a mean HgbA1c of 7.9% to those at 7.0%. Incidence of diabetes-related deaths, myocardial infarctions, and all-cause mortality was significantly lower for each 1% improvement in HgbA1c. This result is promising given that the mean decline in A1c for JUMP participants was 1.3%.

Identifying the Profile of Youth Who Present to the Emergency Department for Psychiatric ReasonsSharon Holder, Dawn Blackhurst, and Eunice Peterson

Objectives: This study examines use of Greenville Memorial Hospital’s (GMH) Emergency Depart-ment (ED) for mental health visits by the pediatric population over a 5-year period.

Methods: A retrospective study of all psychiatric visits of children age 5-18 visiting the GMH ED from Jan. 1, 2010-Dec. 31, 2014, was conducted. Psychiatric visits were identified using the primary ICD-9 diagnosis codes of 290.0-319.0. The population was categorized into 3 age groups based on school-age grades: 5-10, elementary; 11-13, middle school; and 14-18, high school.

Demographic characteristics and ED use were compared among the age groups; P values < .05 were considered statistically significant. Hospital Institutional Review Board approval was obtained before the study.

Results: There were 2,700 visits of the study population. This number made up ~11% of the total psychiatric ED visits in the study timeframe (N = 25 411). Total number of visits increased from 380 in 2010 to 698 in 2014 (84% increase). The greatest increase was in the 11-13 age group (137%). The majority of visits occurred on weekdays (79%); however, the older age groups had a higher percentage of weekend visits (21% vs. 15%). The elementary and middle school groups were pre-dominantly male (60% vs. 40%), while the high school group was predominantly female (52% vs. 48%).

Conclusion: Statistically significant differences were found in ED use characteristics among the 3 age groups. Females were more likely to visit the ED than males. Among the older age groups, those diagnosed with anxiety were more likely to visit the ED. Understanding the profile of youth who use the ED has clinical implications for developing treatment protocols in the ED, community partner-ships, and mental illness preventive practices.

Are We Asking the Right Questions? Screening and Counseling for Environmental Tobacco Smoke Exposure at a Federally Qualified Health CenterElizabeth Holt, Jackson Pearce, McKenna Luzynski, Matthew Delfino, and Lochrane Grant

Background: Interventions that combine provider training with “practice transformation” techniques can greatly increase screening and counseling for environmental tobacco smoke (ETS) exposure during pediatric visits. A clinic-based family smoking cessation intervention is planned at a multisite federally qualified health center (FQHC) serving rural/suburban patients in the Upstate of South Carolina. Rates of smoking at the FQHC are >2 times the national average.

Purpose: To inform intervention design, we assessed the following: (1) provider practices around screening and education for ETS exposure at the pediatric encounter, and (2) provider-stated barri-ers to counseling and referral to cessation resources.

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Methods: Medical record data for all 2017 pediatric visits (N = 7997) were analyzed to determine rates of screening and education around ETS. Provider surveys were administered (n = 11) to identify specific education techniques used and key barriers to counseling and referral.

Results: Preliminary analyses revealed that provider-documented screening and/or education for pediatric ETS exposure occurred in 55% of pediatric encounters. Rates varied by provider/clinic site and visit type. Analyses are underway to assess variation by documented respiratory disease.

Initial results from provider surveys revealed that (1) specific education/counseling techniques used vary widely, (2) smoking cessation resources (such as quitline referrals and nicotine replacement therapy) are underused, and (3) practice-wide changes in electronic medical record prompts could increase counseling and referral to cessation resources.

Conclusion: Implementating clinic-based family smoking intervention could increase the quality of patient counseling and frequency of referral to smoking cessation services, reducing morbidity and mortality among a patient population where smoking rates are high. Data from this pilot study will inform future intervention dissemination across the region.

The Effect of Fad Diets on Patients’ Perceptions of Health and DiseaseCassidy Hood, Robert Masocol, Alex Ewing, Vicki Nelson, and Irfan Asif

Purpose: This study’s purpose was to identify common nutritional perceptions among adult patients in a high-risk family medicine clinic.

Methods and Study Design: The method used was a cross-sectional survey. A paper survey was distributed to adult patients within a high-risk family medicine residency clinic from September 2017-October 2017.

Results: A total of 220 adult patients were surveyed (69% female; 50% African American, 38% Caucasian) with the majority of patients between 25-65 years old (75%) with a BMI >25 (80%). A total of 45% of patients identified as being overweight/obese, 55% identified as having diabetes, 42% identified as having hypertension, and 29.5% identified as having hyperlipidemia.

Approximately 63% of participants described a healthy diet to include fruits and vegetables, with only 23.6% of those patients eating 5 or more servings of fruits or vegetables per day; 28.6% of participants could not describe what constituted a healthy diet. Also, 31.3% of patients have used fad diets in the past, with only 15.4% of patients considering fad diets healthy.

A total of 30.4% of patients identify the media as a major influence on their dietary choices (18.2% TV and social media).

Conclusions: Participants identified a healthy diet as plant-based, though few follow this recommen-dation. Nearly 33% of patients report trying a fad diet.

Significance: This study identifies the significant overall lack of knowledge and understanding of ap-propriate nutrition, including the common belief in and use of fad diets, and the poor insight of chronic disease and its link to nutrition among adult patients in a high-risk family medicine clinic. It is imperative that sufficient patient counseling and education on healthy diets be conducted on a regular basis.

Leader Mindfulness, Unit Well-Being, and Patient CareChelsea LeNoble, Michelle Flynn, Marissa Shuffler, Nastassia Savage, Sharon Wilson, and Tod Tappert

Health care leaders must provide positive environments for their employees and their patients de-spite staffing shortages, policy changes, and shifting economic demands. Ensuring leaders possess the right skills is critical for everyone—from nurses, doctors, and staff, to patients and their families. This study considers the impact of leader attributes of mindfulness and emotion regulation on their staff and patients.

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

To examine the impact of leader mindfulness and emotion regulation on unit and patient outcomes, multisource longitudinal data from 698 health care leaders and 123 000 health care employees were analyzed. Mediated regression analyses indicate that (1) leader mindfulness improves emotion regulation strategies and leader-unit relationship quality, and (2) a high-quality leader-unit relation-ship improves the unit’s ability to recover from work stress and provide high-quality patient care. These results suggest that mindful leaders are more likely to use appropriate emotion regulation strategies at work, foster quality relationships and well-being norms with their staff, and facilitate top-notch patient care.

The ability of leaders to manage themselves and their employees is crucial for health care. When leaders are ineffective, their employees are more likely to burn out, and their patients are less likely to receive effective care. The result not only costs hospitals millions, but also reduces the overall health of patient populations served. These findings highlight the importance of leadership devel-opment programs that improve leaders’ mindfulness and emotion regulation skills and that foster a healthier organizational culture.

Implementation of the Survey of Well-Being of Young Children (SWYC) Form in a Primary Care Office to Improve Screening of Children 2 Months to 5 Years of AgeEric Lessard and Sara Ryder Emerson

Introduction: The American Academy of Pediatrics and Bright Futures recommend monitoring all children for developmental progression and social determinants of health at well-child check evalua-tions. Because a variety of tools are available to meet screening requirements, patients often receive multiple screening forms per visit, which is laborious for families and clinical staff alike.

Tufts University developed a comprehensive screening tool, the Survey of Well-Being of Young Chil-dren (SWYC), which includes developmental, interpersonal/behavioral, and social determinants of health screening for children 2 months through 5 years old. Our aim was to use this tool to improve pediatric screening in our clinic by approximately 20%.

Material and Methods: Baseline data for correct distribution of screening tools were obtained from retrospective chart audits of children 0-5 years old seen at the Greenville Health System (GHS) Center for Family Medicine during a 2-month period. The SWYC form was then introduced via small group educational sessions involving physicians and clinic staff. One month after implementation, chart audits were repeated measuring percentage of forms completed by caregivers.

Results: Before SWYC implementation, patients received age-appropriate screening tool(s) 62% of the time. After SWYC introduction, age-appropriate screening tool completion improved to 94%.

Conclusion: This study demonstrates that implementing the SWYC form at the GHS Center for Fam-ily Medicine provided more consistent comprehensive developmental and social screening of chil-dren 0-5 years old.

Increasing Compliance With Consistent Sterile Procedure During Central Line Fluid Changes in the Small Baby Unit of the Neonatal ICU to Decrease the Central Line-Associated Bloodstream Infection (CLABSI) Rate Melissa Motes and Michael Stewart

The purpose of this project was to increase compliance with consistent sterile procedure during central line fluid changes in the Small Baby Unit of the neonatal ICU to decrease the CLABSI rate and maintain the lower rate.

The framework for this quality improvement was the Iowa Model of Evidence-Based Practice. To increase compliance during central line fluid changes, a PICC nurse (nurse using a peripherally in-

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serted central catheter) was present to assist during the line change. Re-education with a skills check-off on sterile technique and proper process for central line fluid changes was also performed on the unit before the intervention began.

Average compliance for this project was 42%. Overall percent change in the average CLABSI rate was 17%, but the overall percent change for CLABSIs related to maintenance was -50%. This quality improvement showed that the implementation of a PICC nurse to assist during central line changes, in addition to routine education, may not result in an overall decreased CLABSI rate, but may result in reduced CLABSIs that can occur during maintenance of central lines.

This project demonstrated that increasing compliance with proper procedure during central line changes, in addition to continued skills check-offs, can reduce CLABSIs caused by maintenance, resulting in decreased negative outcomes in infants with extremely low birth weight.

Can Commercially Available Voice Prompting Automated Electrical Defibrillators (AEDs) Be Utilized Effectively by Grade School Children?Sally Peterson, Phillip Moschella, Amy Ramsay, and Dotan Shovrin

Purpose: Out-of-hospital cardiac arrest survival rates involving AED use in the United States is poor despite known survival benefits. Lack of knowledge is cited as the main barrier to increased use. We sought to evaluate if grade school children can properly use an AED prompted only by the machine’s voice/self-contained written instructions.

Methods: An Institutional Review Board-approved pilot study was conducted using randomly se-lected grade school children attending a health fair at Clemson University. Participants were given a commercially available AED, surveyed if they had any experience with the device, and then asked to use the device on a simulation manikin. They received only the voice prompting/printed instructions from/on the device itself. The ability to correctly apply/discharge the device across several steps was charted by an observer on a yes/no basis along with the total time (in seconds) to correctly complete AED application.

Results: A total of 35 of 37 students (95%) elected to participate. Of those, 100% of the students had never used the device previously. Of the 35 students, 31 children (88.5%) were able to correctly turn on the device; 24 of 35 students (68.5%) correctly removed and attached the pads to the manikin chest/AED; and 28 of 35 children (80%) correctly discharged the AED shock. Average time to cor-rectly complete AED placement and shock was 81 seconds.

Conclusions: This pilot study demonstrates that grade school children can correctly use an AED with instructions provided by the device itself. Further education and training in grade schools may prove beneficial and cost efficient to improve overall community use of AEDs involving out-of-hospital cardiac arrest.

Reducing Burnout and Improving Meaningful Work Through Medical Resident Poverty Simulation: A Pilot StudyCamiron Pfennig and Chelsea LeNoble

Health care professionals are at significant risk for burnout, characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment. As the intensity of health care work con-tinues to escalate, the need for interventions aimed at mitigating burnout and increasing providers’ sense of meaningful work is apparent.

Health care professionals may experience burnout symptoms when patients miss appointments or do not adhere to prescribed treatments, as this diminishes a sense of meaning in their work. Many times, these behaviors are not a result of the patients’ lack of effort, but stem from external factors related to socioeconomic status and health disparities. To obtain better insight into the lives of their patients, medical residents at a large hospital system participated in a poverty simulation—an im-

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

mersive experience in which participants take on the identity of a person in poverty and navigate their daily challenges.

To examine the impact of the simulation, 24 medical residents who completed a poverty simula-tion and 43 medical residents who did not participate reported their sense of meaningful work and emotional exhaustion both before the poverty simulation and again 1 month later. Results indicate that residents who took part in the poverty simulation reported an increase in meaningful work com-pared to the control group from Time 1 to Time 2. While emotional exhaustion slightly increased for the poverty simulation group, the average score was significantly lower than for the control group.

These findings provide initial support for the effectiveness of a poverty simulation in reducing burn-out and improving meaningful work for medical residents.

Initiation of an Osteoporosis Treatment Program at Our InstitutionDrew Ratner, Billy Clark, Amy Trammell, Laura Boineau, and Kyle Jeray

The purpose of this study is to examine the effectiveness of our osteoporosis program at preventing future fragility fractures in our population of patients with hip fragility fractures, including how many patients were started on an osteoporosis treatment.

Institutional Review Board approval was obtained for this retrospective review. We reviewed all pa-tients treated at our institution for hip fragility fractures from January 2013-July 2013. The primary outcome measure was the number of patients who met with the osteoporosis nurse practitioner (ONP) and started an osteoporosis medication. Initiation of calcium and/or vitamin D and sub-sequent fragility fracture were also examined. In addition, we examined length of stay in hospital, time from admission to surgical intervention, time from surgery to discharge, ambulatory status on admission and discharge, location of discharge, and mortality.

There were 151 hip fractures deemed to be fragility hip fractures during that period. Average time to surgery was 37 hours (SD = 2.1). Forty-two patients (28%) previously had a fragility fracture. Forty-seven (31%) followed up with the ONP. Of those, 34 were started on an osteoporosis med-ication, and all of them were started on calcium and vitamin D. Overall, 13 patients re-presented before 2017 with a subsequent fragility fracture (mean time 398 days to refracture), 5 of which were being treated by the ONP. This finding is an improvement compared to nationwide averages (~20%).

This study shows promise for the initial stages of our osteoporosis program in providing osteoporo-sis treatment following fragility fractures.

Employing the Patient-Centered Collaborative Care Approach: A Case Study of a Complex Geriatric Patient With Psychopathology of Treatment-Resistant Depression and Primary HyperparathyroidismJoel Saul, Sharon Holder, and Jonathan Lokey

Primary hyperparathyroidism is a relatively common endocrine disease with many nonspecific physical symptoms as well as potentially serious psychiatric effects. Incidence of the illness, severity of symptoms, and poorer outcomes are all positively correlated with increasing patient age. The Pa-tient-Centered Collaborative Care Approach is a demonstrable method of coordinating patient care, reducing the burden on patient advocates, and improving patient outcomes. Use of the Patient-Cen-tered Collaborative Care Approach has not previously been well described in treating psychiatric manifestations of primary hyperparathyroidism.

Using the example of an elderly woman admitted with complex psychopathology and a diagnosis of primary hyperparathyroidism, this case illustrates the value of the Patient-Centered Collaborative Care Approach in (1) establishing accurate diagnoses, (2) reducing harm from comorbidities, (3) improving patient outcomes, and (4) potentially reducing hospital costs.

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The case exemplifies the potential benefits of implementing the Patient-Centered Collaborative Care Approach in treating a medically complex patient hospitalized for psychiatric complaints.

A diagnosis of primary hyperparathyroidism was made, and a multidisciplinary team treated this patient using the Patient-Centered Collaborative Care Approach. This team involved psychiatry, in-ternal medicine, and endocrine surgery, as well as family members.

Parathyroid adenoma was confirmed and mass was removed surgically. The patient made a rapid and dramatic improvement, and her depressive symptoms remitted. The critical importance of ap-plying clinical flexibility, questioning available data, and employing a collaborative team approach to the evolution of a diagnosis is addressed.

Caring for Caregivers: Identifying Personality Risk Factors in Burnout DevelopmentNastassia Savage, Zachary Klinefelter, Marissa L. Shuffler, Camiron Pfennig, and Ronald Pirrallo

Burnout is a well-recognized issue in health care, where it negatively impacts patient care (eg, Atkin-son et al, 2017) and physician suicide risk (Shanafelt et al, 2011). Although the estimates of burnout prevalence vary, a study found 50% of medical residents and fellows were burned out and exhibited symptoms of depression (Dyrbye et al, 2014). One predictor has been that personality (eg, extro-version, agreeableness, conscientiousness, intellect, neuroticism) as certain traits were more prone to burnout (eg, McManus et al, 2004; Ripp et al, 2011; Swider and Zimmerman, 2010; Zellars et al, 2000). This study assesses the role of personality in burnout development longitudinally.

We used the mini-IPIP to evaluate personality in 10 first-year ED residents prior to residency (June 2017) and the MBI-HSS to assess burnout before residency and every 4 weeks starting in Septem-ber 2017. Using general linear model repeated measures analyses, results indicate that extroversion and intellect significantly predict burnout development for emotional exhaustion and depersonaliza-tion, and that agreeableness, conscientiousness, and neuroticism did not.

The above results should be used cautiously, as they are limited by the small sample and reliance on self-report survey data. However, they provide some support for the role of personality in burnout development in residents and should be reassessed in other, larger, more diverse samples (eg, de-partments). Doing so could help target interventions to offer assistance to those residents more at risk for developing burnout than others. Additionally, at-risk residents could be offered extra support and guidance (eg, mentors, relaxation activities) to limit the development of burnout.

Return to Sport as Outcome Measure for Shoulder Instability: Surprising Findings in Nonoperative Management in a High School Athlete PopulationEllen Shanley, Charles A. Thigpen, Lauren Ruffrage, Douglas J. Wyland, Michael J. KIssenberth, and John M. Tokish

Objectives: Recurrence rates have traditionally been used as a proxy for “failure” when comparing con-servatively vs. operatively managed patients with anterior shoulder instability. Return to sport has been evaluated as an outcome proxy after surgical intervention, but no study has compared conservative vs. operative management using sustained return to sport as the main outcome measure. The purpose of this study was to compare results between conservatively and operatively treated patients as to their ability to return to uninterrupted sport in a subsequent season after an anterior instability event.

Methods: We identified and followed 179 scholastic athletes treated for a confirmed diagnosis of anterior shoulder instability. Ninety-seven were treated initially with conservative manage-ment; 32 were managed surgically. Patients were excluded if they did not have remaining eligibil-ity to play (were high school seniors) or were treated with benign neglect (neither conservative nor operative treatment). Ultimate success was defined as “return and completion of the subse-quent season without time loss due to any shoulder-related diagnosis.” We substratified by age,

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

sport, and type of instability event (subluxation vs. dislocation) using ANOVA and binary logistic regression.

Results: In the conservatively managed group, 85% achieved ultimate success by returning to play a complete subsequent season of scholastic athletics in the same sport without time loss due to a shoulder condition. In the surgical group, 72% achieved this status (P < .05). Age did not differ between the 2 groups. Patients were 5 times less likely to return to sport if they had sustained a dislocation requiring reduction compared to a subluxation confirmed as an anterior instability event (OR: 4.96, 95% CI = 1.2-9.6).

Conclusion: Patients treated conservatively for an anterior shoulder instability event were far more likely to have a “successful” outcome than published results if the definition of outcome is changed from “no recurrence” to “completion of a subsequent season in their same sport.” Patients sustaining a subluxation were nearly uniformly successful in doing so. While surgical success using this defi-nition was quite lower, there was likely a selection bias in the decision-making process due to bone loss, surgeon preference, or other factor. Nevertheless, the data would suggest that if a patient’s goal is to return to the same level of sport and complete the next season, conservative management is highly effective. Further study to determine whether these results hold with longer term follow-up is warranted, but the routine fixation of the first-time dislocator based on better outcomes is called into question depending on one’s definition of success.

Using Epic to Measure Referral Rates by Greenville Health System Pediatricians to Developmental and Behavioral Support ServicesMegan Schmalz, Julia Moss, Jacqueline Forrester, Sarah Griffin, Christopher Wilson, and Kerry Sease

The purpose of this study was to examine the rate at which Greenville Health System (GHS) pedi-atric primary care providers refer patients with developmental and behavioral concerns to Help Me Grow South Carolina (HMG SC) and to understand the most common concerns among children being referred.

The study examined a cohort of patients from May 2016-April 2017 who may have benefited from HMG services based on age (<4 years) and identification of a possible developmental delay (through commonly used diagnosis codes). Referrals to HMG, as well as to early intervention services, were analyzed. In this population (N = 1654), the most frequent diagnoses were general speech and de-velopmental delays. Average age at diagnosis was 20.3 months, with the majority of patients being male (63.3%). A total of 7.8% of patients were referred to HMG; however, 74.2% of patients referred to HMG were connected to early intervention services.

GHS physicians who use HMG are making age- and diagnosis-appropriate recommendations to HMG, resulting in a clinically significant rate of connection to services; however, a missed opportuni-ty exists currently because of low referral rates. The sample also displayed a gender disparity in diag-nosing developmental delays and behavioral concerns, similar to results found in existing literature.

The study highlighted the need for a more streamlined approach to physician referral to HMG and other support services. It also informed a pilot project (GHS Pediatric Support Services), whereby physicians can easily refer to HMG and other community services through 1 simple referral within the medical record.

Impact of an Alert Reduction Strategy on Pharmacist Alert Override Rates Within a Clinical Decision Support SystemJohn Schoonover, Becky Sawyer, Lucy Crosby, Alyson Ghizzoni-Burns, and Jun Wu

Clinical decision support (CDS) provides information electronically to help the clinician make in-formed treatment decisions. Benefits of CDS include reduced medication errors, improved quality of care, and enhanced efficiency.

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A major consideration of CDS implementation is the large number of clinical checking alerts gener-ated during order entry and verification. If alerts are frequent but not consistently meaningful and actionable, clinicians become desensitized over time. Desensitization, also known as alert fatigue, can lead to clinician frustration and patient harm as important alerts are overlooked. Opportunities exist within CDS systems to customize alerts by various methods, including filtering visibility by certain disciplines only (eg, pharmacists only), filtering by severity level, changing the severity level, and turning off/on completely.

The study objective is to determine if reducing pharmacist-specific alerts reduces alert fatigue (override rates per 100 orders) and improves pharmacist perceptions of utility.

This prospective, systemwide, pre/postintervention, quality improvement study will be conducted over a 6-month period. The preintervention phase will include pharmacist education and a brief sat-isfaction survey. Following the education and a committee-based review and approval process, CDS alerts will be modified to target a 10% reduction. Pharmacist satisfaction and override rates will be measured and compared to preintervention values during the postintervention phase.

The primary endpoint is pharmacist override rate per 100 orders. Secondary endpoints include change in total number of alerts, pharmacist override reasons, satisfaction survey results, pharma-cist intervention data, and number of reported medication events.

Study outcomes and data collection are currently underway.

Comparing Telephone-Based Diabetes Education to Resident Clinic Standard of Care in Uncontrolled Type 2 Patients With DiabetesHenry Schwartz, Caroline Clary, Gail Chastain, and Meenu Jindal

Introduction: The morbidity and mortality of type 2 diabetes, as well as the disease’s contribution to our national health care cost burden, cannot be overstated. The resident clinic with its primarily underserved population of patients offers a unique opportunity for residents to care for notoriously difficult-to-manage patients who have diabetes.

Methods: Fifty-two patients using our internal medicine residency clinic for primary care were en-rolled August 2016. Primary enrollment criteria were a diagnosis of diabetes mellitus type 2 and a most recent hemoglobin A1c >9.0 at time of enrollment. Twenty-six patients were randomized into the intervention arm of the study. These patients received 6 months of diabetes education over the telephone via a certified diabetes educator employed by the clinic. The primary outcome measure was hemoglobin A1c as collected by the PCP as part of standard of care.

Results: Following a rolling schedule of enrollment starting August 2016, the intervention arm of the study was completed August 2017. Hemoglobin A1c data were gathered and analyzed comparing trends between the control and intervention arms.

Conclusion: Developing new and innovative ways to improve blood glucose control in historically difficult-to-control patients with diabetes represents an exciting area of ongoing research in primary care medicine. A cost-effective telephone intervention program used to both educate patients and identify barriers to care would be a perfect example of such an intervention. As any intervention needs to be evidence based, this study represents the first stages of development of such a program.

Comparison of High- vs. Low-Fidelity Simulation Models for AHA CPR Training in Middle School StudentsBijal Shah, David Wong, Sally Peterson, Phillip Moschella, Amy Ramsay, and Dotan Shvorin

Purpose: To test the ability of middle school students to learn American Heart Association (AHA) “CPR Anytime“ training using both high- and low-fidelity simulation models.

Background: Current rates of bystander CPR in South Carolina remain dismal despite known survival

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

benefits. Programs have been targeted at high schools and adult community events with mixed results. Multiple countries have trialed CPR training in elementary and middle schools, but costs of the simulation models necessary for training are expensive and bulky.

Methods: Commercially available high-fidelity simulation manikin models will be assessed against simple air bellows foot pumps to test their noninferiority during AHA CPR Anytime training of 450 students at a local charter middle school. These results will also be compared to a historical cohort of high school students using similar manikin-only based training. We will test for retention and ability using established methods from the AHA included with the training program.

Outcomes: We anticipate that the simple air bellows will provide a noninferior training model as com-pared to the expensive and bulky manikins. These widely available air bellows are inexpensive and may entice more districts/schools to implement training that would otherwise have been deemed too costly.

Conclusion: This program is designed to expand the scope and dissemination of CPR Anytime train-ing by providing a lower cost/fidelity option comparable to the AHA CPR training, which we hope will improve bystander CPR rates through education of local youth.

Critical Social Thinking and Mindfulness Skills as Levers for Facilitating Health Care Unit Engagement and Unit Climate for Patient Safety: A Longitudinal Examination of the Impact of Conscious Leadership and ProfessionalismMarissa Shuffler, Chelsea LeNoble, Michelle Flynn, Dana Verhoeven, Nastassia Savage, Pamela Farago, Tiffany Cooper, Sharon Wilson, and Terrie Long

In health care, emotional demands and stress can negatively impact relationships among employ-ees, reducing engagement and increasing turnover (Ahearn, 2006). Leaders can play a key role in addressing these challenges. In particular, leaders who are provided with developmental activities to refine the skill of navigating relationships with and among their employees are more likely to set team climates that foster employee engagement and reinforce patient safety.

Empirical evidence has suggested that focusing on self-awareness, social dynamics, and mindful-ness may be particularly beneficial for health care leadership. Accordingly, this research provides a multimethod, multisource, long-term examination of the impact of a leadership and professional skill development program focused on such competencies: the Conscious Leadership & Profession-alism program. This program is derived from evidence-based practices and principles of leadership development and training design.

Data from 1189 health care units and their leaders were collected over the course of 4 years to eval-uate longitudinal effects on unit outcomes of engagement and climate for patient safety. Multilevel structural equation modeling analyses were then conducted.

Program participation and learning are significantly and positively predictive of leader-employee re-lationships, greater workplace engagement, and positive perceptions of patient safety climate. This type of training program is a promising avenue for continued exploration and application in health care, as it may help to improve both employee engagement and the patient experience.

Strategic Development of a Research Experience Enrichment Program (REEP) in the Emergency Medicine DepartmentDotan Shvorin, Ronald Pirrallo, Kevin Taaffe, and Phillip Moschella

Objective: To establish a Greenville Health System (GHS)-Clemson University (CU) collaboration that seeks to improve patient care processes and outcomes by applying engineering methods within the GHS Department of Emergency Medicine.

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Background: The Creative Inquiry (CI) program matches motivated undergraduate and graduate stu-dents with CU faculty to facilitate imaginative engaged learning and cross-disciplinary interactions to produce the next generation of scholars.

Hypothesis: Can the CU CI program be adapted to the GHS health care environment to advance GHS scholarship and workforce development?

Methods: Under the leadership of an embedded CU scholar, 6 teams of CI students were matched with GHS EM clinical faculty and EM residents to investigate these topics: CPR training effective-ness, quantifying physician distractions, clinician decision making under fatigue, describing clinician physiologic biomarker variability during a shift, understanding the effect of consultant use on ED operations, and TB screening modeling.

Outcomes: Six teams incorporating 12 EM GHS faculty, 6 EM residents, 18 undergraduates, and 5 graduate students formed REEP to answer these 6 research questions over the course of a year. The teams generated 6 confirmed abstract conference presentations that secured a CU internal award of $6000 for dissemination.

Conclusion: REEP appears to have adapted the CU CI framework to produce promising scholarly work and expose nearly 2 dozen CU students to the health care environment this year. Future work will evaluate if these teams generate peer-reviewed manuscripts and track how many CU REEP partici-pants pursue careers in health care.

Statin Shared Decision Making and Patient Education StudyBrittany Kizer Stovall, Alexa Bianchi, and Meenu Jindal

The 2013 American College of Cardiology/American Heart Association task force on practice guidelines demonstrated a new perspective focusing on atherosclerotic cardiovascular disease risk reduction from statins. With a paradigm move to patient-centered medicine, shared deci-sion making (SDM) tools have created a collaborative way for medical decision making. One key question remains: Does SDM and use of an aid increase patients’ knowledge and continuation of taking statins?

The study population consisted of lower socioeconomic status, current statin use, and no known history of cardiovascular disease or coronary artery disease. The sample size was 27 individuals.

During their clinic visit, patients were asked to answer a survey regarding their knowledge of the mechanism of action, risks, and benefits of statins. Upon finishing the initial survey, patients then underwent an SDM session using the Mayo Clinic SDM Statin Aid. After the session, patients were asked to complete a postintervention survey. Scores of the initial and postintervention surveys were compared by paired t-test.

Two main areas were assessed: (1) the association between statin SDM aid and education, and (2) the impact on their decision to continue to take a statin. There was a 33% increase in patient edu-cation with a P value of < .001, along with a 94% willingness to continue to take their statin after the SDM. Therefore, SDM was shown to be effective for patient education; SDM should be encouraged and emphasized in academic training regardless of educational level or socioeconomic status.

Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospec-tive Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014 Julie Summey, Liwei Chen, Rachel Mayo, Elizabeth Charron, Jennifer Hudson, Windsor Westbrook Sherrill, and Lori Dickes

Background: Few coordinated treatment programs address the needs of infants and families strug-gling with the effects of substance use. In 2003, Greenville Memorial Hospital launched the Man-aging Abstinence in Newborns (MAiN) program, providing multidisciplinary, coordinated, commu-nity-based care for neonatal abstinence syndrome (NAS). The aim of this study was to compare the

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SELECTED 2018 GHS RESEARCH SHOWCASE ABSTRACTS

outcomes of MAiN infants to comparable NAS infants receiving traditional care between 2006-2014 in South Carolina.

Methods: De-identified sociodemographic and clinical data on MAiN infants, as well as NAS infants not treated with MAiN, were obtained from statewide databases in South Carolina. Study measures included medical and safety outcomes, health services use, child protective services involvement, emergency services utilization, and inpatient readmissions.

Results: We identified 110 infants who received the MAiN intervention and 356 SC NAS infants who were potentially MAiN-eligible. Overall, no significant differences existed in the two groups regard-ing medical or safety outcomes or child protective services involvement.

Traditional care NAS infants were more likely to be treated in a higher level nursery (69% vs. 0%). MAiN infants had approximately $20 000 less per birth in average charges (P < .001) and an almost 5 days shorter length of stay (P < .001) than did the traditional care NAS infants. MAiN infants also had a lower percentage of ED visits (P = .01) assessed as possibly or likely NAS-related, as com-pared to traditional care NAS infants.

Conclusion: This study demonstrates the potential value of implementing the MAiN model in eligible NAS infants. Benefits of implementation may include significant cost reduction without sacrificing quality and safety.

New Public Health Partnership: GHS Emergency Department and SC DHEC HIV Surveillance ProgramBen Theobald, Jackie Barnabe, and Phillip Moschella

Purpose: To describe the implementation, relevance, and results of an emergency department (ED)-based HIV surveillance system.

Methods and Results: South Carolina’s Department of Health and Environmental Control (DHEC) and Greenville Health System (GHS) have partnered to establish a program in which DHEC sub-sidizes “opt-out” HIV screening as performed on existing blood samples from individuals between the ages of 18-64 presenting to the ED with unknown HIV status. Newly diagnosed HIV-positive patients are then linked to initial treatment and follow up.

From Dec. 1, 2017-March 1, 2018, this program has tested 1123 individuals with 7 initial positives and 3 confirmed HIV diagnoses (0.26%). Of the remaining initial positive results, 2 were negative on confirmatory testing, and 2 others were previously diagnosed but were unknown in our medical record system.

Summary: HIV screening in the ED setting results in identification of undiagnosed individuals and successfully links them to treatment and follow up.

Clinical Relevance: Our program demonstrates how a government-supported, ED-based population health surveillance program can provide a positive impact on public health. With 30.2% of all HIV transmissions in the United States coming from undiagnosed individuals, the Office of National AIDS Policy set a goal that no more than 10% of HIV-positive patients in the this country remain undiagnosed. At present, that rate is 14% nationally and 16.6% in South Carolina, indicating a need for increased HIV surveillance. This program serves this purpose by identifying undiagnosed cases of HIV, subsequently decreasing HIV transmission rates and prevalence in South Carolina.

Cardiorespiratory Health, Muscular Strength/Endurance, and Fat-Free Mass Are Improved After 12 Weeks of Exercise Therapy in Cancer SurvivorsJennifer Trilk, Ryan Porter, Noreen Denham, and W. Larry Gluck

No studies to our knowledge have examined the effects of a nurse-supervised exercise program using certified cancer exercise trainers on anthropometric and physiologic variables in cancer survi-vors across multiple diagnoses.

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Purpose: To evaluate effects of Moving On, the Greenville Health System (GHS) Cancer Institute’s Oncology Rehabilitation program.

Methods: GHS oncologists referred eligible cancer survivors to Moving On (12 weeks, 1 hour, 3 days/week of exercise therapy) after having completed initial chemotherapy or on maintenance chemo-therapy and/or current radiation therapy. Baseline and follow-up evaluations included body mass index (BMI), body composition (body fat mass [FM], fat-free mass [FFM]), peak oxygen uptake (VO2 peak), muscle strength (1-repetition maximum [1-RM]), and muscle endurance (repetitions at 40% 1-RM).

Results: Survivors (N = 11, 54.5 ± 14.8 years of age; 82% women) who completed the program with ≥80% attendance were evaluated. No change in BMI or FM occurred; however, body FFM and trun-cal FFM increased 3.5% (3.3 lb, P = .02) and 3.8% (1.7 lb, P = .01), respectively. VO2 peak increased 20.2% (3.5 ± 0.9 ml/kg/min; P < .01), upper and lower body 1-RM increased 27.4% (24.8 ± 8.6 lb, P < .05) and 19.1% (35.8 ± 11.3 lb, P < .05), respectively. Upper- and lower-body muscular endurance increased 76.8% (+18.1 ± 1.9 repetitions, P < .001) and 76.3% (+13.7±2.8 repetitions, P = .001), re-spectively (absolute data reported as mean ± SE).

Conclusion: Cancer survivors across diagnosis groups and age ranges experienced anthropometric and physiologic benefits after taking part in Moving On.

Applicability to Health Care: Standard-of-care for cancer survivors should include exercise therapy to help ameliorate the deleterious effects of cancer therapy and maximize return to function and quality of life.

Randomized Controlled Trial of a 4-week Mindfulness Intervention Among Cancer SurvivorsMichael Wirth, Regina Franco, Sara Wagner Robb, Katie Daniels, Kerri Susko, Matthew Hudson, and Mark O’Rourke

Mindfulness-based practices encourage palliation through meditation, thus reducing stress and distress. This study examined a 4-week Mindfulness-Based Cancer Survivorship (MBCS) program among cancer survivors at Greenville Health System. Cancer survivor participants applied mindful-ness practices to managing pain, fatigue, sleepiness, depression, and inflammatory and metabolic biomarkers. Investigators enrolled and randomized 40 cancer survivors to an intervention or control arm. The intervention group received a 4-week MBCS program with a 3-month follow-up postin-tervention. The control group received standard breathing exercises. Outcome measures assessed at baseline and 1-week postintervention included Pittsburg Sleep Quality Index (PSQI), Perceived Stress Scale (PSS), actigraphy data, and inflammation and metabolic biomarkers.

Analyses did not reveal any differences between intervention and control participants for the 4-week or 3-month time points. The intervention arm evidenced a reduction in sedentary hours at 4 weeks compared to baseline (-0.3 hours, P = .04). At the 3-month follow-up, the intervention participants significantly reduced their PSS (13.2 vs. 11.0, P = .06), PSQI score (8.1 vs. 6.3, P = .01), and sedentary hours (-1 hour, P = .03) compared to baseline. Their steps also increased by 1128 steps per day (P = .04). No changes were observed for biomarkers.

This study suggests that cancer survivors exposed to a mindfulness intervention report favorable changes to self-perceived stress, sleep quality, and physical activity. However, future research may identify potentially mediating factors such as dose of session, feasibility, and effectiveness among cancer patients. Additionally, future studies should consider enrolling more symptomatic patients to better evaluate effectiveness of such programs.

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Special Article

Best Overall ResearchIndividual Human Galectin-9 Domains Display Distinct Antimicrobial PropertiesAnna Blenda, Nourine Kamili, Christian Gerner-Smidt, Anita Venkatesh, Connie Arthur, and Sean Stowell

Best Investigation of High-Value CareProject REVISE—The Impact at GHSElizabeth Tyson, Karen Eastburn, Jeremiah Smith, and Kevin Polley

Best Investigation of Patient EngagementIntegrating Personalized Patient Goals and Priorities Into Clinical CareMelanie Cozad, Gulzar Merchant, Rasmine Baker, and Kait Crosby

Best Investigation of DiabetesJUMPing Into Diabetes ControlLauren Hassan, Sheena Henry, Gail Chastain, and Meenu Jindal

Best Investigation of Population HealthImproving Population Health Through Hypertension ControlSusan Sutherland, Brent Egan, Robert Davis, David Ramsey, and Robert Hanlin

Early Investigator’s AwardAntibiotic Irrigation of the Surgical Site Decreases Incidence of Surgical Site Infection After Open Ventral Hernia RepairLily Fatula, Allison Foster, Hamza Abbad, Joseph Ewing, Ben Hancock, William Cobb, Alfredo Carbonell, and Jeremy Warren

Best Medical Student ResearchPneumatic Dilation Improves Esophageal Emptying on Timed Barium Esophagram in Patients With Esophago-Gastric Junction Outflow ObstructionClaire Shin, Wojciech Blonski, Joseph Ewing, Joel Richter, and Steven Clayton

Best Nursing Student ResearchBioelectrical Impedance Analysis Accuracy: Factors That Affect Test Results Maeve Murphy, Brandi Ingram, Sarah Feus, and Jillian Robert

Factors Affecting Salvage Rate of Infected Prosthetic MeshHamza Abbad, Benjamin Hancock, William Cobb, Alfredo Carbonell, and Jeremy Warren

Fine Needle Aspiration vs. Gencut Core: Is One Biopsy Method Superior in Terms of Tissue Volume?Tiffanie Aiken, Allyson Hale, Joseph Ewing, William Bolton, James Stephenson, and Sharon Ben-Or

Full List of Abstracts Presented at the 2018 GHS Health Sciences Center Research Showcase

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24 GHS Proc. December 2018; 3 (1): 23-28

Volumetric Analysis of Patients Undergoing Abdominal Wall Reconstruction After Preoperative Progressive PneumoperitoneumJohn Allen, Jeremy Warren, and Joseph Bittle

The Clinical and Economic Impact of a Physical Activity-Based Treatment Program for Severe ObesityIrfan Asif, Joseph Ewing, Samantha Reid, Nathan Schewecke, Allyson Hale, Vicki Nelson, and Michael Wiederman

Comparison of Electrocardiographic Interpretation Criteria for Use in Athlete Screening Elizabeth Barton, Vicki Nelson, Joseph Ewing, Brett Toresdahl, Jonathan Drezner, and Irfan Asif

Understanding Pedal Usage and Foot Movement Characteristics of Older DriversLeah Belle, Yubin Xi, Johnell Brooks, Paul Venhovens, Shayne McConomy, John DesJardins, Patrick Rosopa, Kevin Kopera, Constance Truesdail, Nathalie Drouin, Sarah Hennessy, Stephanie Tanner, Jeremy McKee, and Kathy Lococo

Assessing Barriers to Implementing Shared Decision MakingAlexa Bianchi, Brittany Crum, and Meenu Jindal

Early Warning Response System in GHS School-Based Health CentersHolly Bryan, Laura Rolke, Sarah Griffin, Jacqueline Forrester, Laura Johnson, and Kerry Sease

An Integrated Passive Strain Sensor for Dynamic Hip Screws to Monitor Intertrochanteric Fracture Stability with RadiographyNathan Carrington, Bryce Kunkle, Caleb Behrend, Tom Pace, Paul Millhouse, Jeffrey Anker, and John DesJardins

Construction of Chimeric Histone Methyltransferase Complexes in Saccharomyces cerevisiae Generates Unique Phenotypes and Clarifies the Roles of MLL1 and Set1 Complex Accessory ProteinsRenee Chosed, Arnav Lal, David Klein, Emery Longan, Marian Baker, Sasha Gogoli, Jingtian Wang, and Sami Alkoutami

Exercise Programming Correlates With Patient Success in a Comprehensive Pediatric Weight Loss ProgramJenna Crowder, Irfan Asif, Cara Reeves, Kerstin Blomquist, Erin Brackbill, Sarah Griffin, Dorothy Schmalz, Kerry Sease, Laure Utecht, and Vicki Nelson

Supportive Care Metrics for a Community Oncology AYA ProgramElizabeth Cull, John McAlhany, Sarah Taylor, Heather Bowers, Kerri Susko, and Aniket Saha

Beyond Bates: Advanced Physical Exam Series for Medical StudentsRyan Dean and Steven Connelly

Analysis of Positive Responses to 2 Different Heart Health Questionnaires in NCAA Division 1 AthletesJoseph DeStefano, Hampton Williams, Douglas Reeves, Joseph A. Ewing, and Irfan M. Asif

Evaluation of CarFit Criteria Compliance and Knowledge of Seat AdjustmentNathalie Drouin, Shayne McConomy, Johnell Brooks, Paul Venhovens, Yubin Xi, Patrick Rosopa, John DesJardins, Kevin Kopera, Leah Belle, Connie Truesdail, Stephanie Tanner, Kathy Lococo, Loren Staplin, and Elin Schold Davis

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FULL LIST OF 2018 GHS RESEARCH SHOWCASE ABSTRACTS

Model for Management of Medicare Patients With Congestive Heart Failure and Multiple Chronic ConditionsBrent Egan, Joel Amidon, Bruce Hanlin, and Irfan Asif

Geographic Variation in the Treatment of Proximal Humerus Fracture in the Medicare PopulationSarah Floyd, Joel Campell, Charles Thigpen, Mike Kissenberth, and John Brooks

Persistent Functional Neurological Symptom Disorder Spontaneously Remits With ECT TreatmentRaphaela Fontana, Frank Clark, and Benjamin Griffeth

Optimization of Automated Guided Vehicle System in Health Care FacilityKade Gilstrap, Amogh Bhosekar, Tugce Isik, Sandra Eksioglu, and Robert Allen

Improving Quality to Facilitate ResearchAmanda Goode, Katie Daniels, and Matthew Hudson

The Correlation Between Residency Applications and Standardized Behavioral Assessments for Gaining Entry Into a Graduate Medical Education ProgramVincent Green and Ardalan Ahmadi

Self-Perceptions on Fitness to Drive in Collegiate Athletes Following a Sport-Related ConcussionSteven Greene, Yathavan Rajakulasingam, Vicki Nelson, Alex Ewing, and Andrew Albano

Wearable Motion Quantification and Electronic Diaries for Long-Term Monitoring of Parkinson’s Disease Aaron Hadley, Enrique Urrea Mendoza, Nicola Mennucci, Carol Zimmerman, Joseph Giuffrida, Zoltan Mari, Michelle Burack, Ilia Itin, Fredy Revilla, and Dustin Heldman

Micromotion and Strength of the Glenoid Component in Reverse Total Shoulder ArthroplastyShannon Hall, David Baxley, Michael Kissenberth, Josh Karnes, Nick Metcalfe, and John DesJardins

Identifying the Profile of Youth Who Present to the Emergency Department for Psychiatric ReasonsSharon Holder, Dawn Blackhurst, and Eunice Peterson

Biomechanical Effects of Therapeutic Horseback Riding on Balance and Gait Confidence in the ElderlyAnne Marie Holter, Julia Gates, John DesJardins, Kristine Vernon, and Marieke Van Puymbroeck

Are We Asking the Right Questions? Screening and Counseling for Environmental Tobacco Smoke Exposure at a Federally Qualified Health CenterElizabeth Holt, Jackson Pearce, McKenna Luzynski, Matthew Delfino, and Lochrane Grant

The Effect of Fad Diets on Patients’ Perceptions of Health and DiseaseCassidy Hood, Robert Masocol, Alex Ewing, Vicki Nelson, and Irfan Asif

Potential Benefits of a Separate Instrument Setup Room or Induction Room Adjacent to the Operating RoomBrandon Lee, Dee San, Kevin Taaffe, Lawrence Fredendall, Yann Ferrand, Amin Khoshkenar, Alexis Fiore, Anjali Joseph, and Scott Reeves

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Leader Mindfulness, Unit Well-Being, and Patient CareChelsea LeNoble, Michelle Flynn, Marissa Shuffler, Nastassia Savage, Sharon Wilson, and Tod Tappert

Implementation of the Survey of Well-Being of Young Children (SWYC) Form in a Primary Care Office to Improve Screening of Children 2 Months to 5 Years of AgeEric Lessard and Sara Ryder Emerson

Influence of Opioid Referrals on Physical Therapy Outcomes for Patients with Neck and Back PainK. Markut, D. Dunn, A. Lutz, T. Denninger, E. Shanley, M. Kissenberth, and C. Thigpen

Understanding How Clinicians Use Epic in Clinical Practice: A Time and Motion StudyBenjamin Martin, Mark Wess, Nicholas Perkins, Renee Tollison, and Ronald Gimbel

Evaluation of Chronic Lung Disease and Surgical Retinopathy of Prematurity Outcomes After a Change to Bubble Continuous Airway PressureAra Messamer, Reese Clark, and Felecia Wood

Cervical Interbody Spacer with Passive Radiographic Fusion Status IndicatorPaul Millhouse, Md Arifuzzaman, Apeksha Rajamanthrilage, Nathan Carrington, Caleb Behrend, John DesJardins, and Jeffrey Anker

Interdisciplinary Care Huddles and RoundingChristy Morris, Terri LaRusso, Annette Dunphy, and Paari Gopalakrishnan

Increasing Compliance With Consistent Sterile Procedure During Central Line Fluid Changes in the Small Baby Unit of the Neonatal ICU to Decrease the Central Line-Associated Bloodstream Infection (CLABSI) RateMelissa Motes and Michael Stewart

Two-Year Retest Variability of ImPACT Baseline Concussion Testing in High School AthletesVicki Nelson, Irfan Asif, Kyle Cassas, J. Brandon Harris, J. Aldrin Enabore, and W. Franklin Sease Jr.

On the Path to Total Knee ArthroplastyAlicia Oostdyk, Noor Alshareef, Rasmine Baker, Melanie Cozad, Sarah Floyd, and Paul Siffri

Can Commercially Available Voice Prompting Automated External Defibrillators (AEDs) Be Utilized Effectively by Grade School Children?Sally Peterson, Phillip Moschella, Amy Ramsay, and Dotan Shovrin

Reducing Burnout and Improving Meaningful Work Through Medical Resident Poverty Simulation: A Pilot StudyCamiron Pfennig and Chelsea LeNoble

Initiation of an Osteoporosis Treatment Program at Our InstitutionDrew Ratner, Billy Clark, Amy Trammell, Laura Boineau, and Kyle Jeray

To Develop an Inexpensive, but Versatile Device to Elevate the Field of Point-of-Care Clinical AnalysisPaige Reed, Jeff Edenfield, and Carlos D. Garcia

Leveraging Electronic Health Record Data to Improve Diabetes Control and Prevention: The DART Quality Improvement ProgramSara Sarasua, Kim Roberts, Susan Sutherland, Robert Davis, David Ramsey, C. Shaun Wagner, and Brent Egan

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FULL LIST OF 2018 GHS RESEARCH SHOWCASE ABSTRACTS

Employing the Patient-Centered Collaborative Care ApproachJoel Saul, Sharon Holder, and Jonathan Lokey

Caring for Caregivers: Identifying Personality Risk Factors in Burnout DevelopmentNastassia Savage, Zachary Klinefelter, Marissa Shuffler, Camiron Pfennig, and Ronald Pirrallo

Impact of an Alert Reduction Strategy on Pharmacist Alert Override Rates Within a Clinical Decision Support SystemJohn Schoonover, Becky Sawyer, Lucy Crosby, Alyson Ghizzoni-Burns, and Jun Wu

Using Epic to Measure Referral Rates by Greenville Health System Pediatricians to Developmental and Behavioral Support ServicesMegan Schmalz, Julia Moss, Jacqueline Forrester, Sarah Griffin, Christopher Wilson, and Kerry Sease

Stability of Parkinson’s Disease Subtypes Based on a Cluster Analysis in a Large CohortArtur Schumacher-Schuh, Oswaldo Lorenzo-Betancor, James Leverenz, Liana Rosenthal, Ted Dawson, Marilyn Albert, Zbigniew Wszolek, Owen Ross, Dennis Dickson, Joseph Quinn, Kathryn Chung, Amie Peterson-Hiller, Alberto Espay, Johnna Devoto, Fredy Revilla, Jennifer Goldman, Glenn Stebbins, Bryan Bernard, Tom Montine, Cyrus Zabetian, and Ignacio Mata

Comparing Telephone-Based Diabetes Education to Resident Clinic Standard of Care in Uncontrolled Type 2 Patients With DiabetesHenry Schwartz, Caroline Clary, Gail Chastain, and Meenu Jindal

Comparison of High- vs. Low-Fidelity Simulation Models for AHA CPR Training in Middle School StudentsBijal Shah, David Wong, Sally Peterson, Phillip Moschella, Amy Ramsay, and Dotan Shvorin

Return to Sport as Outcome Measure for Shoulder InstabilityEllen Shanley, Charles Thigpen, Lauren Ruffrage, Douglas Wyland, Michael Kissenberth, and John Tokish

Assessing an Exercise Vital Signs in Pediatric PatientsEmily Sherrard, Robert Masocol, Irfan Asif, J. Alex Ewing, and Vicki Nelson

Critical Social Thinking and Mindfulness Skills as Levers for Facilitating Health Care Unit Engagement and Unit Climate for Patient SafetyMarissa Shuffler, Chelsea LeNoble, Michelle Flynn, Dana Verhoeven, Nastassia Savage, Pamela Farago, Tiffany Cooper, Sharon Wilson, and Terrie Long

Strategic Development of a Research Experience Enrichment Program (REEP) in the Emergency Medicine DepartmentDotan Shvorin, Ronald Pirrallo, Kevin Taaffe, and Phillip Moschella

Statin Shared Decision Making and Patient Education StudyBrittany Kizer Stovall, Alexa Bianchi, and Meenu Jindal

Early Treatment Innovation for Opioid-Dependent Newborns: A Retrospective Comparison of Outcomes, Utilization, Quality, and Safety, 2006-2014Julie Summey, Liwei Chen, Rachel Mayo, Elizabeth Charron, Jennifer Hudson, Windsor Westbrook Sherrill, and Lori Dickes

Reduction in Type 2 Diabetes Markers With Longer Duration of Breastfeeding in the Peri/postnatal Epigenetic Twins Study (PETS): Theoretical Epigenetic MechanismsHeide Temples, Yuk Jing Loke, William Bridges, Richard Saffery, and Jeffrey Craig

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New Public Health Partnership: GHS Emergency Department and SC DHEC HIV Surveillance ProgramBen Theobald, Jackie Barnabe, and Phillip Moschella

Cardiorespiratory Health, Muscular Strength/Endurance and Fat Free Mass Are Improved After 12 Weeks of Exercise Therapy in Cancer SurvivorsJennifer Trilk, Ryan Porter, Noreen Denham, and W. Larry Gluck

Using X-ray Excited Luminescent Chemical Imaging (XELCI) to Image Changes in pH on the Surface of Implanted Medical Devices in Order to Detect and Monitor Implant-Associated InfectionUnaiza Uzair, Donald Benza, Fenglin Wang, Yash Raval, Tzuen-Rong Tzeng, Caleb Behrend, and Jeffrey Anker

White Coat Syndrome in the Obese Pediatric Population: The Case for Ambulatory Blood Pressure MonitoringScott Walters, Ransome Eke, Hannah Kline, Shane Sundlie, Kerry Sease, and Jonathan Markowitz

Prophylactic Placement of Permanent Synthetic Mesh at the Time of Ostomy Closure Prevents Incisional Hernia FormationJeremy Warren, Lucas Beffa, Alfredo Carbonell, Jennifer Cull, Brent Sinopoli, Joseph Ewing, Cedrek McFadden, Jay Crockett, and William Cobb

Randomized Controlled Trial of a 4-week Mindfulness Intervention Among Cancer SurvivorsMichael Wirth, Regina Franco, Sara Wagner Robb, Katie Daniels, Kerri Susko, Matthew Hudson, and Mark O’Rourke

Immediate and Delayed Retention of Stroke and Healthy Lifestyle Education Among Middle School StudentsLeah Wormack, Jordan Gainey, Amber Frazier, Chibueze Ubah, Chloe Gonzalez Jackson, Anita Venkatesh, Natalia Rincon, Leanne Brechtel, Brantley Dick, Megan Fredwall, Jennifer Cook, Sarah Konklin, Vivek Venkatesh, and Thomas Nathaniel

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29GHS Proc. December 2018; 3 (1)

Miscellany

2018 GHS Residents and FellowsFamily MedicineJoel Rhein Amidon, MDMohamed Balout, MD Courtney Lynn Duffy, MDSheelah Orinion Gervacio, MDEric Lessard, MDLaura Mary Morrison, MD

Primary Care Sports Medicine Elizabeth Eleanor Barton, MDJenna Lynn Crowder, MD

General SurgeryMacKenzie Johanna Bartz, MDWilliam John Berglind, MDKyle Vernon Conway, MDAshley Jana Marie Jones, MDSean Patrick McGrath, MDKatherine Ferstadt Pellizzeri, MD

Minimally Invasive SurgeryJohn Michael Allen, MDDavid Gregory Pearson, MD

Vascular Surgery Brian Michael Freeman, MDJonathan Jay Sexton, MD

Internal MedicineMary Crouse Blumer, MDCaroline Rebecca Clary, MDBonnie Elizabeth DeBusk, DOMichael Joseph Haden, MDSheena Marie Henry, MDJohn John, MD

Catherine Lea Morris, MDRachel Anne Quaney, MDKerolos George Rizk, DOLaura Emily Roache, DOHenry Vernon Schwartz III, MDAshton Scott Townsend, DO

Internal Medicine/PediatricsCraig Michael Anderson, MDMarla Turner Chapman, MDClay Martin Crosby, MDKatie Lauren Mclemore McQueen, MDDennis Ryan Paulk, MD

Obstetrics & GynecologyLaura Dopson Almquist, MDCharis Nailah Chambers, MDKelly Whittaker Kline, MDLauren Jamison Pinckney, MDKatie Mellington Vemireddy, MDAndrew James White, MD

Orthopaedic SurgeryAneel Kumar Jiwanlal, MDMichael Robert Koerner, MDMark Christian Daniel Moody, MDDrew Alan Ratner, MD

Orthopaedic Sports Medicine Joel Robert Campbell, MDJohn Larson Glomset, MDRyan Stephenson Rowland, MDLane Nicholas Rush, MD

Adult Reconstruction Surgery Nicholas Miladore, MD

PediatricsEric Michael Bankert, DOMeghan Skinner Jordan, MDLindsey Brianne McAmis Gouge, MDMatthew Christopher McGee, MDAshtin Danielle Nix, MDColton Lee Ragsdale, MDChristine Nabil Riyad, MDAndreea Iulia Stoichita, MDGrace Ann Twitty, MDJohn Robert Winningham, MDVictoria Lynnette Winningham, MD

Developmental-Behavioral PediatricsSteven Hsiang-Yu Ma, MD

PharmacyAlyssa Marie Gaietto, PharmDChristopher Michael Nappi, PharmDAmy S. Robinson, PharmDJohn Hunter Schoonover, PharmDAllyson Sleeman, PharmDPatrick D. Walker, PharmDBrittany M. Wills, PharmD

Psychiatry Lisa Bush Bostic, MDRyan Ashley Greene, MDNahid Nadiri, MDAndrew J. Ruege, MDJoel Robert Saul, DO

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30 GHS Proc. December 2018; 3 (1)

Miscellany

USC School of Medicine Greenville Class of 2018Alyssa AdkinsKenzie AlexanderCarly AtwoodBobby BaranelloJanet BasingerLeighann BlackJoey BlackwellEthan BrownAndrew BuhrStefano Cardin PozoKrupesh DaveRaquel DenisPhillips DeRidderCatherine EntrikenHannah EnglandDavid ErazoBrian FazzoneAlicia FirestoneTim FletcherMegan FredwallJordan GaineyAnne Marie GerstnerTaylor GirolamoKalie GoodmanMike Granade

Scott GriffinTee GriscomWes HardgroveHarry HicklinCody HillMichael HoodMeghan HudakStephen HudsonEleasa HulonCalley HuntsingerSven IvankovicBrian JonesMatt KerrHannah KlineBrittany LamontAlex LeaAndrew LeeWilliam LightleJordan MalrayWhitney MayberryKatrina MorganGabrielle MorrisWes ParkerShuler PolkBen Ramsey

Natalia RinconJulia RobisonGreg RoopTaylor RozierElla ShrederHannah ShullJasmine SmithNoah SmithCrystal SosaGrace SpencerMark SpencerHope SprungerClay StaffordBianca StewartShane SundlieAndrew SwartzNate TeagueLauren Ashley TiptonMary Van WertCasey WangShannon WentworthJeremiah WhiteJessica-Ashley WilliamsBailey WootenSara Yi

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Miscellany

Emergency Medicine1. Baird M, Asif I. Medications helpful for

changing sleep schedules in athletes. Sports Health. 2018;10(1):31-5.

2. Bitner ME, Benjamin L, Farris SR. Clinical learning in an urban emergency department: an examination of residents’ abilities for reflec-tive practice. GHS Proc. 2017;2(2):115-24.

3. Brown PA, Shah B. Emerging treatment op-tions for acute lymphoblastic leukemia: focus on CAR T-cell therapy. J Natl Compr Canc Netw. 2018;16(5S):651-5.

4. Burton E, Stanley M. SIRS criteria: a nidus for bias and how to minimize it. EM Resident Magazine. 2018;45(1):22-3.

5. Callaway DW, Puciaty A, Robertson J, Hannon T, Fabiano SE. Case report: life saving appli-cation of commercial tourniquet in pediatric extremity hemorrhage. Prehosp Emerg Care. 2017;21(6):786-8.

6. Chan T, McColl T, Luckett-Gatopoulos S, Purdy E, Eicken JJ. Medical education in cases. In: Thoma B, ed. Academic Life in Emergency Medicine. 1st ed. San Francisco, CA. 2017;3(1).

7. Chou A, Brevil A, Eicken JJ. Use of point-of-care ultrasound to measure hematoma volume. Vis J Emerg Med. 2017;8:44-5.

8. Del Vecchio A, Pfennig CL, Moschella PC. 84 medical student response to improvisation and acting training: novel curriculum pilot study. Ann Emerg Med. 2017;70(4):S34-5.

9. Faul M, Lurie P, Kinsman JM, Dailey MW, Crabaugh C, Sasser S. Multiple naloxone administrations among emergency medical service providers is increasing. Prehosp Emerg Care. 2017;21(4):411-9.

10. French DM, Bridges EP, Hoskins MC, Andrews CM, Nelson CH. Myasthenic crisis in pregnancy. Clin Pract Cases Emerg Med. 2017;1(4):291-4.

11. Gimbel RW, Pirrallo RG, Lowe SC, Wright DW, Zhang L, Woo MJ, Fontelo P, Liu F, Con-

nor Z. Effect of clinical decision rules, patient cost and malpractice information on clini-cian brain CT image ordering: a randomized controlled trial. BMC Med Inform Decis Mak. 2018;18(1):20.

12. Hanlin RB, Asif I, Wozniak G, Sutherland SE, Shah B, Yang J, Davis RA, Bryan ST, Rakotz M, Egan BM. Measure Accurately, Act Rapid-ly, and Partner With Patients (MAP) improves hypertension control in medically underserved patients: Care Coordination Institute and American Medical Association Hypertension Control Project Pilot Study results. J Clin Hypertens. 2018;20(1):79-87.

13. Ko C, Baird M, Close M, Cassas KJ. The diag-nostic accuracy of ultrasound in detecting dis-tal radius fractures in a pediatric population. Clin J Sport Med. 2017;1. PMID: 29189342.

14. Loberger J, Sharp J, Polley KA. Implemen-tation of a clinical management pathway to shorten time to antibiotic delivery in febrile patients with sickle cell disease in a pedi-atric emergency department. GHS Proc. 2017;2(2):137-43.

15. Pfennig CL, Slovis C. Electrolytes. In: Walls R, Hockberger R, Gausche-Hill M, eds. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier, 2017;1516-32.

16. Pinto L, Lein A, Mahoque R, Wright DW, Sasser S, Staton CA. A cross-sectional explor-atory study of knowledge, attitudes, and prac-tices of emergency health care providers in the assessment of child maltreatment in Maputo, Mozambique. BMC Emerg Med. 2018;18(1):11.

17. Polk R, Blackhurst DW, Moschella PC. 392 disposition destination does not affect patient experience ratings in real-time in an urban academic emergency department. Ann Emerg Med. 2017;70(4):S153-4.

18. Taylor R, Blackhurst DW, Moschella PC. 361 patient experience scores are affected by timing of survey administration in an urban

2018 Publications of Greenville Health System Medical and Scientific Staff

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academic emergency department. Ann Emerg Med. 2017;70(4):S142-3.

19. Vandervall K, Yehl MA, Tjiattas-Saleski L. Paronychia. Osetopath Fam Physician. 2018;10(1):23.

20. Warren J, Stoddard C, Hunter AL, Horton AJ, Atwood C, Ewing JA, Pusker S, Cancel-laro VA, Walker KB, Cobb W, Carbonell A, Morgan RR. Effect of multimodal analgesia on opioid use after open ventral hernia repair. J Gastrointest Surg. 2017;21(10):1692-9.

21. Weinmeister KL, Lerner EB, Guse CE, Ateyyah KA, Pirrallo RG. Dispatcher CPR in-structions across the age continuum. Prehosp Disaster Med. 2018;33(3):342-5.

22. Williams S, Nelson R, Kashif R, Goff T, Simon L, Janse MC. Demographic varia-tion in the injury patterns of adult cyclists admitted to a large US healthcare network: a five-year review. Trauma. 2017; DOI: 10.1177/1460408617740903.

Family Medicine23. Asif I, Ewing JA, Reid S, Schewecke N, Hale

A, Nelson V, Wiederman M. Clinical and economic impact of a physical activity-based wellness program to treat severe obesity: 2-year follow-up. Clin J Sport Med. 2018;28(2):239-48.

24. Barton E, Nelson V, Asif I. Chest pain and palpitations – lacrosse. Med Sci Sports Exerc. 2018;50(5):124.

25. Barton E, Nelson V, Ewing JA, Asif I. Com-parison of electrocardiographic interpretation criteria for use in athlete screening. Clin J Sport Med. 2018;28(2):239-48.

26. Crowder J, Sease WF, Asif I, Nelson V. Painful arm mass – weight lifting. Med Sci Sports Exerc. 2018;50(5):124.

27. Egan BM, Sutherland SE, Rakotz M, Yang J, Hanlin RB, Davis RA, Wozniak G. Improving hypertension control in primary care with the Measure Accurately, Act Rapidly, and Partner with Patients protocol results at 5 and 12 months. Hypertension. 2018;72:1320-7.

28. Goode AP, Taylor S, Hastings SN, Stanwyck C, Coffman CJ, Allen KD. Effects of a home-based telephone-supported physical activity program for older adult veterans with chronic low back pain. Phys Ther. 2018;98(5):369-80.

29. Gunn AH, Schwartz TA, Arbeeva LS, Callahan LF, Golightly Y, Goode A, Hall CH, Huffman K, Iversen MD, Pathak A, Taylor S, Allen KD. The frequency of and patient characteristics as-sociated with fear of movement in adults with

symptomatic knee osteoarthritis. Arthritis Care Res. 2017;69(12):1826-33.

30. Mitchell-Bennett L, Zolezzi M, LuBeth P, Sal-dana M, Vatcheava K, Meyer L, Patterson SF, Reininger B. Coordinated care beyond clinical settings for patients with uncontrolled diabe-tes. Published online Nov 2017 as part of the American Public Health Association Annual Meeting, Atlanta, GA.

31. Nelson V, Masocol RV, Ewing JA, Wiederman M, Asif I. Associations between the physical activity vital sign and cardiometabolic disease in high-risk pediatric patients. Med Sci Sports Exerc. 2018;50(5):202.

32. Nelson V, Rao A, Sease WF, Shanley E, Asif I. Hazing prevalence and perceptions among collegiate athletes. Clin J Sport Med. 2018;28(2):184-230.

33. Nelson V, Sease WF, Cassas KJ, Harris B, Enabore JA, Asif I. Two-year retest variabil-ity of ImPACT baseline concussion testing in high school athletes. Clin J Sport Med. 2018;28(2):239-48.

34. Nelson V, Masocol RV, Ewing JA, Johnston S, Hale A, Wiederman M, Asif I. Association between a physical activity vital sign and car-diometabolic disease in high-risk patients. Clin J Sport Med. 2018;PMID: 29601348.

35. Taylor S, Oddone EZ, Coffman CJ, Jeffreys AS, Bosworth HB, Allen KK. Cognitive mediators of change in physical functioning in response to a multifaceted intervention for managing os-teoarthritis. Int J Behav Med. 2018;25(2):162-70.

36. Taylor S, Hughes JM, Coffman CJ, Jeffreys AS, Ulmer CS, Oddone EZ, Bowsorth HB, Yancy WS, Allen KD. Prevalence of and characteris-tics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis. BMC Musculoskelet Disord. 2018;19(1):79.

Medicine37. Akiyama MJ, Feffer R, von Oehsen WH, Litwin

AH. Drug purchasing strategies to treat people with hepatitis C in the criminal justice system. Am J Public Health. 2018;108(5):607-8.

38. Akiyama M, Macdonald R, Jordan A, Colum-bus D, Schwartz J, Litwin AH, Eckhardt B, Carmody E. Linkage to HCV care and reincar-ceration following release from New York City jails. J Hepatol. 2018;68(suppl 1):S175-6.

39. Akiyama MJ, Agyemang L, Arnsten JH, Heo M, Norton BL, Schackman BR, Linas BP, Litwin AH. Rationale, design, and methodology of a

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2018 PUBLICATIONS

trial evaluating three models of care for HCV treatment among injection drug users on opioid agonist therapy. BMC Infect Dis. 2018;18(1):74.

40. Andorsky D, Coleman M, Yacoub A, Melear JM, Brooks HD, Fanning SR, Kolibaba KS, Lansigan F, Reynolds C, Li J, Liu D, Llorente M, Ricker JL, Sharman JP. Response rate to lenalidomide plus rituximab (R2) as inde-pendent of number of prior lines of therapy: interim analysis of initial phase of MAGNIFY phase IIIb study of R2 followed by mainte-nance in relapsed/refractory indolent NHL. J Clin Oncol. 2018;36(suppl 15):7516.

41. Batchelder AW, Cockerham-Colas L, Peyser D, Reynoso SP, Soloway I, Litwin AH. Perceived benefits of the hepatitis C peer educators: a qualitative investigation. Harm Reduction J. 2017;14(1):67.

42. Bhullar P. Tracking patients in communi-ty-based palliative care through the Cen-ters for Medicare and Medicaid Services Healthcare Innovation Project. J Palliat Med. 2017;20(11):1231-6.

43. Callahan SP, Tanner NT, Chen A, Macro T, Silvestri GA, Pastis NJ. Comparison of the thin convex endobronchial ultrasound broncho-scope to standard endobronchial ultrasound and flexible bronchoscope. US Resp Pulm Dis. 2017;2(1):33-6.

44. Cheung EM, Edenfield WJ, Mattar B, Anthony SP, Mutch PJ, Chanas B, Smith MJ, Hepner A. Safety and pharmacokinetics of bendamustine rapid-infusion formulation. J Clin Pharmacol. 2017;57(11):1400-8.

45. Conway B, Dore G, Altice F, Litwin AH, Grebely J, Dalgard O, Gane E, Shibolet O, Luetkemeyer A, Nahass R, et al. A172 C-edge co-star: risk of reinfection following successful therapy with elbasvir (EBR) and grazoprevir (GZR) in persons who inject drugs (PWID) receiving opiod agonist therapy (OAT). J Can Assoc Gastroenterol. 2018;1(suppl 1):299-300.

46. Deming R, Ford MM, Moore MS, Lim S, Perumalswami P, Weiss J, Wyatt B, Shukla S, Litwin AH, Reynoso S, et al. Evaluation of a hepatitis C clinical care coordination pro-gram’s effect on treatment initiation and cure: a surveillance-based propensity score matching approach. J Viral Hepat. 2018;25(11):1236-43.

47. Dirix LY, Takacs I, Edenfield WJ, et al. Ave-lumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast can-cer: a phase 1b JAVELIN Solid Tumor study. Breast Cancer Res Treat. 2018;167(3):671-86.

48. Edenfield WJ, Martin JC, O’Rourke MA, Cull E, Chung K. Improving care delivery for patients with rare cancers: a phase II trial of durvalumab in combination with tremilu-mimab in subjects with advanced rare tumors in a large community health care system. J Clin Oncol. 2018;36(suppl 15):e18535.

49. Egan BM, Li J, Sarasua SM, Davis RA, Fiscella KA, Tobin JN, Jones D, Sinopoli A. Choles-terol control among uninsured adults did not improve from 2001-2004 to 2009-2012 as disparities with both publicly and privately insured adults doubled. J Am Heart Assoc. 2017;6(11):e006105.

50. Escalona Villasmil, P, Siegel, RD. Diet and nutrition in the treatment of prediabetes and diabetes. Scientific American Medicine. In: Robinson MK, ed. Hamilton (ON): Deck-er Intellectual Properties, Apr 2018. DOI: 10.2310/7900.9033.

51. Forero-Torres A, Ramchandren R, Yacoub A, Edenfield WJ. Results from a phase ½ study of INCB050465, a highly selective and highly po-tent PI3Kδ inhibitor in patients with relapsed or refractory B-cell malignancies (CITA-DEL-101). Blood. 2017;130.

52. Fullard ME, Thibault DP, Hill A, Fox J, Bhatti DE, Burack MA, Dahodwala N, Haberfeld E, Kern DS, Klepitskava OS, Urrea-Mendo-za E, Myers P, Nutt J, Rafferty MR, Schwalb JM, Shulman LM, Willis AW. Utilization of rehabilitation therapy services in Parkin-son disease in the United States. Neurology. 2017;89(11):1162-9.

53. Gambacorti-Passerini C, Orlov S, Zhang L, Braiteh F, Huang H, Esaki T, Horibe K, Ahn JS, Beck JT, Edenfield WJ, Shi Y, Taylor M, Ta-mura K, Van Tine BA, Wu SJ, Paolini J, Selaru P, Kim TM. Long-term effects of crizotinib in ALK-positive tumors (excluding NSCLC): a phase 1b open-label study. Am J Hematol. 2018;93(5):607-14.

54. Gambacorti-Passerini C, Orlov S, Zhang L, Edenfield WJ. Safety and efficacy of crizo-tinib in ALK-positive lymphomas: a phase 1b open-label study. Blood. 2017;130:4128.

55. Gluck WL, Martin JC, Edenfield WJ, Chung K, Arguello D. Prolonged response of widely metastatic HER2-positive colon cancer to trastuzumab therapy. Colorectal Cancer. 2017;6(2):57-61.

56. Graham CS, Trooskin SB, Moorman AC, Rupp LB, Gordon SC, Zhong Y, Holmberg SD, Dore GJ, Hajarizadeh B, Belperio PS, et al. Over-

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coming barriers to eliminate hepatitis C. Infect Dis Clin N Am. 2018;32(2):i.

57. Grebely J, Dalgard O, Conway B, Cunning-ham EB, Bruggmann P, Hajarizadeh B, Amin J, Bruneau J, Hellard M, Litwin AH, Marks P, Quiene S, Siriragavan S, Applegate TL, Swan,T, Byrne J, Lacalamita M, Dunlop A, Matthews GV, Powis J, Shaw D, Thurnheer MC, Weltman M, Kronborg I, Cooper C, Feld JJ, Fraser C, Dillon JF, Read P, Gane E, Dore GJ. Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injec-tion drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial. Lancet Gastroenterol Hepatol. 2018;3(3):153-61.

58. Grebely J, Bruneau J, Lazarus JV, Dalgard O, Bruggmann P, Treloar C, Hickman M, Hellard M, Roberts T, Crooks L, Midgard H, Larney S, Degenhardt L, Alho H, Byrne J, Dillon JF, Feld JJ, Foster G, Goldberg D, Lloyd AR, Reimer J, Robaeys G, Torrens M, Wright N, Maremmani I, Norton BL, Litwin AH, Dore GJ. Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. Int J Drug Policy. 2017;47:51-60.

59. Guo Q, Shuford S, McKinley B, Rippon M, Cornett W, O’Rourke MA, Schammel DP, Edenfield J, Kaplan DL, Crosswell HE, DesRochers T. 3D modeling of immune cell interactions in breast cancer and prediction of immunotherapy response. Cancer Res. 2017;77(suppl 13):4834.

60. Hakimi R, Hierholzer S. Aorto-tracheo/pul-monic fistula from squamous cell carcinoma leading to cerebral air embolism. Published online March 2018 as part of the American Society of Neuroimaging Annual Meeting, Austin, TX. DOI: org/10.1111/jon.12507.

61. Hanlin RB, Asif I, Wozniak G, Sutherland SE, Shah B, Yang J, Davis RA, Bryan ST, Rakotz M, Egan BM. Measure Accurately, Act Rapid-ly, and Partner With Patients (MAP) improves hypertension control in medically underserved patients: Care Coordination Institute and American Medical Association Hypertension Control Project Pilot Study results. J Clin Hypertension. 2018;20(1):79-87.

62. Hasegawa H, Urrea-Mendoza E. Prognosis of post-cardiac-arrest anoxic encephalopathy us-ing felbamate: A case report. Cogent Medicine. 2017;4(1):1331601.

63. Hashmi SK, Lee S, Savani BN, Burns L, Wingard JR, Perales MA, Palmer J, Chow

E, Meyer E, Marks D, Mohty M, Inamoto Y, Rodriguez C, Nagler A, Sauter C, Komanduri KV, Pidala J, Hamadani M, Johnston L, Shah N, Shaughnessy P, Hamilton BK, Majhail N, Kharfan-Dabaja MA, Schriber J, DeFilipp Z, Tarlock KG, Fanning SR, Curtin P, Rizzo JD, Carpenter PA. ASBMT practice guidelines committee survey on long term follow-up clinics for hematopoietic cell transplant survivors. Biol Blood Marrow Transplant. 2018;24(6):1119-24.

64. Heldman DA, Urrea-Mendoza E, Lovera LC, Schmerler DA, Garcia X, Mohammad ME, McFarlane MCU, Giuffrida JP, Espay AJ, Fernandez HH. App-based bradykinesia tasks for clinic and home assessment in Parkinson’s disease: reliability and responsiveness. J Par-kinson’s Dis. 2017;7(4):741-7.

65. Heo M, Meissner P, Litwin AH, McKee MD, Karasz A, Chambers EC, Yeh MC, Wylie-Rosett J. Reply to Walter et al.’s letter to the editor. Stat Methods Med Res. 2018:962280218767707. PMID: 29633630.

66. Hinen HB, Gathings RM, Shuler MJ, Wine Lee L. Successful treatment of facial milia in an infant with orofaciodigital syndrome type 1. Pediatr Dermatol. 2018;35(1):e88-9.

67. Litwin AH, Drolet M, Nwankwo C, Torrens M, Kastelic A. Perceived barriers related to the management of HCV infection among physicians prescribing opioid agonist therapy: the C-SCOPE study. Small. 2017;27:13.

68. Lodise TP, Schrank JH. The emperor’s new clothes: prospective observational evaluation of the association between the day 2 van-comycin exposure and failure rates among hospitalized patients with MRSA bloodstream infections (PROVIDE). Open Forum Infect Dis. 2017;4(suppl 1):S30-1.

69. McDermott DF, Joseph RW, Ho T, Vaisham-payan U, Ali S, Matrana M, Alter R, Edenfield J, Blanchette S, Gan L, Atkins MB. 896PA Phase (Ph) 1 dose finding study of X4P-001 (an oral CXCR4 inhibitor) and axitinib in patients with advanced renal cell carcinoma (RCC). Ann Oncol. 2017;28(suppl 5):317-8.

70. Millard M, Lotstein A, Holmes L, Schammel DP, Chung K, Edenfield J, Crosswell HE, DesRochers T. Abstract 1923: Paired isolation and expansion of CSC and CTC from primary small cell lung cancer patient tissue and blood using the 3DKUBE bioreactor platform. Can-cer Res. 2017;77(suppl 13):1923.

71. Muench SC, Akiyama MJ, Heo M, Litwin AH.

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2018 PUBLICATIONS

Mo1392-effect of direct acting antivirals on health-related quality of life in patients who inject drugs. Gastroenterol. 2018;154(6):S1192.

72. Naughton MJ, Case LD, Peiffer A, Chan M, Stieber V, Moore D, Falchuk S, Piephoff J, Edenfield WJ, Giguere J, Loghin M, Shaw EG, Rapp SR. Quality of life of irradiated brain tumor survivors treated with donepezil or placebo: results of the WFU CCOP research base protocol 91105. Neuro-Oncol Pract. 2018;5(2):114-21.

73. Norton BL, Akiyama MJ, Zamor PJ, Litwin AH. Treatment of chronic hepatitis C in patients receiving opioid agonist therapy: a review of best practice. Infect Dis Clin North Am. 2018;32(2):347-70.

74. Norton BL, Fleming J, Bachhuber MA, Steinman M, DeLuca J, Cunningham CO, Johnson N, Laraque F, Litwin AH. High HCV cure rates for people who use drugs treated with direct acting antiviral therapy at an urban primary care clinic. Int J Drug Policy. 2017;47:196-201.

75. Pahlavanzadeh M, Hakimi R. Lumbar punc-ture as a treatment for IVH in patients with a good neurological examination. Published online March 2018 as part of the American Society of Neuroimaging Annual Meeting, Austin, TX. DOI: org/10.1111/jon.12507.

76. Rajan A, Gulley JL, Spigel DR, Iannotti N, Chandler JC, Wong DJL, Leach JW, Edenfield WJ, Wang D, Redfern CH, Grote HJ, von Heydebreck A, Ruisi MM, Munshi N, Kelly K. Avelumab (anti–PD-L1) in patients with platinum-treated advanced NSCLC: 2.5-year follow-up from the JAVELIN Solid Tumor trial. J Clin Oncol. 2018;36(suppl 15):9090.

77. Revilla F, Urrea-Mendoza E. Perceived ac-tivities and participation outcomes of a Yoga Intervention for individuals with Parkinson’s disease: a mixed methods study. Int J Yoga Ther. 2018;28(1):51-61.

78. Revilla F. Functional improvements in Parkin-son’s disease following a randomized trial of yoga. Evid-Based Complmt Alt Med. 2018 Feb. ID 8516351.

79. Revilla F. Large-scale exploratory genetic anal-ysis of cognitive impairment in Parkinson’s disease. Neurbiol Aging. 2017;56:211.e1-7.

80. Sarasua SM, Li J, Hernandez GT, Ferdinand KC, Tobin JN, Fiscella KA, Jones D, Sinopoli A, Egan BM. Opportunities for improving cardiovascular health outcomes in adults younger than 65 years with guideline-recom-

mended statin therapy. J Clin Hypertension. 2017;19(9):850-60. PMID: 28480530.

81. Shuter J, Litwin AH, Sulkowski MS, Feinstein A, Bursky-Tammam A, Maslak S, Weinberger AH, Esan H, Segal KS, Norton B. Cigarette smoking behaviors and beliefs in persons living with hepatitis C. Nicotine Tobacco Res. 2017;19(7):836-44.

82. Sivakumar S. Cerebral pathophysiology in extracorporeal membrane oxygenation: pitfalls in daily clinical management. Crit Care Res Pract. 2018; PMID: 29744226.

83. Sivakumar S. Mystery case: central nervous system post transplant lymphoproliferative disorder. Neurology. 2017;89(4):e32-7.

84. Teixeira PA, Bresnahan MP, Laraque F, Litwin AH, Shukla SJ, Schwartz JM, Reynoso S, Perumalswami PV, Weiss JM, Wyatt B, et al. Telementoring of primary care providers deliv-ering hepatitis C treatment in New York City: results from Project INSPIRE. Learning Health Systems. 2018;2(3):e10056.

85. Von Hoff DD, Rasco DW, Heath EI, Munster PN, Schellens JHM, Isambert N, Le Tourneau C, O’Neil BH, Mathijssen RH, Lopez-Martin JA, Edenfield WJ, Martín M, LoRusso PM, Bray GL, DiMartino J, Nguyen A, Liu K, Laille E, Bendell JC. Phase I study of CC-486 alone and in combination with carboplatin or nab-pacli-taxel in patients with relapsed or refractory solid tumors. Clin Cancer Res. 2018;24(17):4072-80.

86. Zafar K, Patil N. Inpatient-onset versus outpatient-onset acute coronary syndrome: comparison of clinical features and outcomes. Tex Heart Inst J. 2018;45(3):136-43.

87. Urrea-Mendoza E, Revilla FJ, Rincon N. Clin-ical characterization of Pramipexole induced edema and skin reaction in Parkinson Disease (PD) after one year of follow-up. Neurology. 2018;90(15)(suppl):e1-19.

OB/GYN88. Almquist LD, Likes CE, Stone B, Brown KR,

Savaris R, Forstein DA, Miller PB, Lessey B. Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study. Fertil Steril. 2017;108(6):1063-9. PMID: 29126613.

89. Bonds CL, Roudebush WE, Lessey B. Sperm motility index and intrauterine insemi-nation pregnancy outcomes. GHS Proc. 2017;2(2):125-30.

90. Chang HJ, Yoo JY, Kim TH, Fazleabas A, Young SL, Lessey B, Jeong JW. Overex-

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pression of four joint box-1 protein (FJX1) in eutopic endometrium from women with endometriosis. Reprod Sci. 2018;25(2):207-13. PMID: 28673206.

91. Colón-Caraballo M, Torres-Reverón A, Soto-Vargas JL, Young S, Lessey B, Mendoza A, Urrutia R, Flores I. Effects of histone meth-yltransferase inhibition in endometriosis. Biol Reprod. 2018;99(2):293-307. PMID: 29408993.

92. Eichelberger K. The association between assisted reproduction technology (ART) and abnormal placentation. BJOG. 2018 Jun 13. PMID: 29900643.

93. Eichelberger K, Alson JG, Doll KM. Should race be used as a variable in research on preterm birth? AMA J Ethics. 2018;20(1):296-302. PMID: 29542440.

94. Eichelberger K. Equal pay for equal work in academic obstetrics and gynecology. Obstet Gynecol. 2018;131(2):224-6.

95. Hill A, Lessey B, Flores VA, Taylor HS. Baze-doxifene/conjugated estrogens in combination with leuprolide for the treatment of endometri-osis. Clin Case Rep. 2018;6(6):990-4.

96. Keenan-Devlin LS, Ernst LM, Ross KM, Qadir S, Grobman WA, Holl JL, Crockett A, Miller GE, Borders AEB. Maternal income during pregnancy is associated with chronic placen-tal inflammation at birth. Am J Perinatol. 2017;34(10):1003-10.

97. Matson BC, Quinn KE, Lessey B, Young SL, Caron KM. Elevated levels of adrenomedul-lin in eutopic endometrium and plasma from women with endometriosis. Fertil Steril. 2018;109(6):1072-8. PMID: 29871794.

98. Miller GE, Borders AE, Crockett A, Ross KM, Qadir S, Keenan-Devlin L, Leigh AK, Ham P, Ma J, Arevalo JMG, Ernst LM, Cole SW. Ma-ternal socioeconomic disadvantage is associ-ated with transcriptional indications of greater immune activation and slower tissue matura-tion in placental biopsies and newborn cord blood. Brain Behav Immun. 2017;64:276-84.

99. Miller J, Ahn S, Monsanto S, Khalaj K, Fa-zleabas A, Young S, Lessey B, Koti M, Tayade C. Interleukin-33 modulates inflammation in endometriosis. Sci Rep. 2017;7(1):17903. PMID: 28434870.

100. Palomino WA, Tayade C, Argandoña F, Devoto L, Young SL, Lessey B. The endometria of women with endometriosis exhibit dysfunc-tional expression of complement regulatory proteins during the mid secretory phase. J

Reprod Immunol. 2017 Feb;125:1-7. PMID: 29153978.

101. Strug M, Su R, Kim T, Mauriello A, Young S, Lessey B, Ticconi C, Lim J, Jeong J, Fazleabas A. RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent preg-nancy loss. FASEB J. 2018;32(5):2452-66.

102. Surrey E, Taylor HS, Giudice L, Lessey B, Abrao MS, Archer DF, Diamond MP, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Singh SS, Re-chberger T, Agarwal SK, Duan WR, Schwefel B, Thomas JW, Peloso PM, Ng J, Soliman AM, Chwalisz K. Long-term outcomes of elagolix in women with endometriosis: results from two extension studies. Obstet Gynecol. 2018;132(1):147-60. PMID: 29889764.

103. Taylor HS, Giudice LC, Lessey B, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher C, Simon JA, Carr B, Dmowksi WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K. Treatment of endome-triosis-associated pain with elagolix, an oral GnRH antagonist. N Engl J Med. 2017;377:28-40. PMID: 28525302.

104. Young SL, Savaris RF, Lessey B, Sharkey AM, Balthazar U, Zaino RJ, Sherwin RA, Fritz MA. Effect of randomized serum proges-terone concentration on secretory endometrial histologic development and gene expression. Hum Reprod. 2017;32(9):1903-14. PMID: 28854727.

105. Zhang T, Zhou J, Man G, Liang B, Leung K, Xiao B, Ma X, Huang H, Huang S, Hegde V, Zhong Y, Li Y, Yiu A, Kong G, Kwong J, Ng P, Lessey B, Nagarkatti M, Nagarkatti P, Wang C. MDSCs drive the process of endometrio-sis by enhancing angiogenesis and are a new potential therapeutic target. Eur J Immunol. 2018;48(6):1059-73. PMID: 29460338.

Orthopaedics106. Abildgaard JT, Lonergan KT, Tolan SJ, Kissen-

berth MJ, Hawkins RJ, Washburn R, Adams KJ, Long C, Shealy EC, Motley JR, Tokish J. Liposomal bupivacaine versus indwelling interscalene nerve block for postoperative pain control in shoulder arthroplasty: a prospective randomized controlled trial. J Shoulder Elbow Surg. 2017;26(7):1175-81.

107. Asif I, Annett S, Ewing J, Abdelfattah R. Psychological impact of electrocardiogram screening in NCAA athletes. Brit J Sports Med. 2017;51(20):1489-92.

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2018 PUBLICATIONS

108. Burnikel BG. Amniotic messenchymal stem cells mitigate osteoarthritis progression in a sy-novial macrophage-medicated in vitro explant coculture model. J Tissue Eng Regenerative Med. 2018;12(4):1097-110.

109. Carpenter JE, Bagian JP, Snider RG, Jeray K. Medical team training improves team perfor-mance: AOA critical issues. J Bone Joint Surg. 2017;99(18):1604-10.

110. Denninger TR, Cook CE, Chapman CG, McHenry TP, Thigpen CA. The influence of patient choice of first provider on costs and outcomes: analysis from a physical therapy patient registry. J Orthop Sports Phys Ther. 2018;48(2):63-71.

111. Finkemeier C, Adams J, Bernstein M, Lee MA, Harvey E, Crist BD. Biomechanics – hot topics part II. J Orthop Trauma. 2018;32(suppl)(1):S29-32.

112. Gruber HE, Ashraf N, Cox MD, Ingram JA, Templin M, Wattenbarger JM. Experimental induction of physeal injuries by fracture, drill, and ablation techniques: analyses of immuno-histochemical findings. J Pediatr Orthop. 2017 Nov 16. PMID: 29189533.

113. Hedrick B, Gettys FK, Richards S, Muchow RD, Jo CH, Abbott MD. Percutaneous heel cord release for clubfoot: a retrospective, multicentre cost analysis. J Child Orthop. 2018;12(3):273-8.

114. Hendrix ST, Kwapisz A, Wyland DJ. All-inside arthroscopic meniscal repair technique using a midbody accessory portal. Arthrosc Tech. 2017;6(5):e1885-90.

115. Jackson LT, Crisler MC, Tanner S, Brooks JO, Jeray K. Effects of upper extremity immobi-lization and use of a spinner knob on vehicle steering. Hand. 2017;12(6):597-605.

116. Lazarus D, Farnsworth CL, Jeffords ME, Mari-no N, Hallare J, Edmonds EW. Torsional growth modulation of long bones by oblique plating in a rabbit model. J Ped Orthop. 20181;38(2):e97-103.

117. Luedke C, Kissenberth MJ, Tolan SJ, Hawkins RJ, Tokish J. Outcomes of anatomic total shoul-der arthroplasty with B2 glenoids. JBJS Reviews. 2018;6(4):e7.

118. Madden K, Scott T, McKay P, Petrisor BA, Jeray K, Tanner S, Bhandari M, Sprague S. Predicting and preventing loss to follow-up of adult trauma patients in randomized controlled trials: an example from the FLOW trial. J Bone Joint Surg. 2017;99(13):1086-92.

119. McConomy S, Brooks J, Venhovens P, Xi Y, Ro-sopa P, DesJardins J, Kopera K, Drouin N, Belle L, Truesdail C, Tanner S, Hennessy S, Lococo K,

Staplin L, Schold Davis E. Evaluation of CarFit criteria compliance and knowledge of seat ad-justment. SAE Technical Paper. 2018 Apr 3.

120. Momaya AM, Beicker C, Siffri PC, Kissen-berth MJ, Backes J, Bailey L, Rulewicz GJ, Mercuri JM, Shealy EC, Tokish J, Thigpen CA. Preoperative ultrasonography is unreliable in predicting hamstring tendon graft diameter for ACL reconstruction. Orthop J Sports Med. 2018;6(1):2325967117746146.

121. Momaya AM, Kwapisz A, Choate WS, Kissen-berth MJ, Tolan SJ, Lonergan KT, Hawkins RJ, Tokish J. Clinical outcomes of suprascapular nerve decompression: a systematic review. J Shoulder Elbow Surg. 2018;27(1):172-80.

122. Porter SE, Razi AE, Ramsey TB. Novel strategies to improve resident selection by improving cul-tural fit: AOA critical issues. J Bone Joint Surg. 2017;99(22):e120.

123. Roberson TA, Bentley JC, Griscom JT, Kissen-berth MJ, Tolan SJ, Hawkins RJ, Tokish J. Out-comes of total shoulder arthroplasty in patients younger than 65 years: a systematic review. J Shoulder Elbow Surg. 2017;26(7):1298-1306.

124. Roberson TA, Abildgaard JT, Wyland DJ, Siffri PC, Geary SP, Hawkins RJ, Tokish JT. “Propri-etary processed” allografts: clinical outcomes and biomechanical properties in anterior cruci-ate ligament reconstruction. Am J Sports Med. 2017;45(13):3158-67.

125. Seiler JG, Daruwalla JH, Payne SH, Faucher G. Normal palmar anatomy and variations that im-pact median nerve decompression. J Am Acad Orthop Surg. 2017;25(9):e194-203.

126. Sprague S, Petrisor BA, Jeray K, McKay P, Scott T, Heels-Ansdell D, Schemitsch EH, Liew S, Guyatt GH, Walter SD, Bhandari M. Factors associated with health-related quality of life in patients with open fractures. J Orthop Trauma. 2018;32(1):e5-11.

127. Sprague S, Petrisor B, Jeray K, McKay P, Heels-Ansdell D, Schemitsch E, Liew S, Guyatt G, Walter SD, Bhandari M. Wound irrigation does not affect health-related quality of life after open fractures: results of a randomized con-trolled trial. Bone Joint J. 2018;100-B(1):88-94.

128. Stasikelis PJ, Carpenter AM. Results of casting in severe curves in infantile scoliosis. J Pediatr Orthoped. 2018;38(4):e186-9.

129. Torres EG, Anderson AB, Broome B, Geary SP, Burnikel BG. Liposomal membrane bound bupivacaine versus femoral nerve catheter in TKA. Am J Orthoped. 2017;46(6):e414-8.

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38 GHS Proc. December 2018; 3 (1): 31-46

130. Watson ST, Allen B, Robbins C, Bedi A, Gagnier JJ, Miller B. Does the rotator cuff tear pattern influence clinical outcomes after surgical repair? Orthop J Sports Med. 2018;6(3):2325967118763107.

131. Watson ST, Gudger GK, Long C, Tokish J, Tolan SJ. Outcomes of trabecular metal-backed glenoid components in anatomic total shoul-der arthroplasty. J Shoulder Elbow Surg. 2018;27(3):493-8.

132. Watson ST, Robbins CB, Bedi A, Carpenter JE, Gagnier JJ, Miller BS. Comparison of out-comes 1 year after rotator cuff repair with and without concomitant biceps surgery. Arthros-copy. 2017;33(11):1928-36.

133. Westberry DE, Wack LI, Davis RB, Hardin JW. Femoral anteversion assessment: compar-ison of physical examination, gait analysis, and EOS biplanar radiography. Gait Posture. 2018;62:285-90.

134. Westberry DE, Carpenter AM, Barrera J, Westberry A. Management of tibial bow in fibular deficiency. J Pediatr Orthop. 2018 Apr 20. PMID: 29683857.

135. Westberry, DE. State of the art: amputation and prosthetics. J Pediatr Orthop. 2017;37(sup-pl)(2):S22-5.

136. Westberry DE, Carpenter AM. 3D modeling of lower extremities with biplanar radiographs: reliability of measures on subsequent exam-inations. J Pediatr Orthop. 2017 Aug 2. PMID: 28777285.

137. Xi Y, Brooks J, Venhovens P, Rosopa P, DesJardins J, McConomy S, Belle L, Drouin N, Hennessy S, Kopera K, McKee J, Tanner S, Truesdail C, Lococo K, Staplin L. Under-standing the automotive pedal usage and foot movement characteristics of older drivers. SAE Technical Paper. 2018 Apr 3.

Pathology138. Abrams G, Chapman R, Horton SRW. Re-

fractory hepatic hydrothorax: a rare compli-cation of systemic sclerosis and presinusoidal portal hypertension. Case Rep Hepatol. 2018;2018:2704949.

139. Gudakova I, Kim JP, Meredith J, Webb G. Microbial contamination on touch surfaces in sick- and well-child waiting rooms in pediatric outpatient facilities. Pediatr Infect Dis J. 2017;36(12):e303-6.

140. Hutchinson JC, Fulcher JW, Hanna J, Ward M. Pulmonary tumor thrombotic microangiopa-thy: case report and review of literature. Am J Forensic Med Pathol. 2018;39(1):56-60.

141. Monico J, Miller B, Rezeanu L, May W, Sul-livan DC. Fibroblast growth factor receptor 1 amplification in laryngeal squamous cell carcinoma. PloS One. 2018;13(1):e0186185.

142. Slizewski DH, Heberlein E, Meredith J, Jobe LB, Eichelberger K. Impact of home versus hospital dressing on bacterial contamination of surgical scrubs in the obstetric setting: a ran-domized controlled trial. Am J Infect Control. 2018;46(4):379-82.

143. Snyder B, Beets JW, Lessey B, Horton SRW, Abrams G. Postmenopausal deep infiltrating endometriosis of the colon: rare location and novel medical therapy. Case Rep Gastrointest Med. 2018;2018:9587536.

144. Wapshott T, Schammel C, Schammel DP, Rezeanu L, Lynn M. Primary undifferentiated sarcoma of the meninges: a case report and comprehensive review of the literature. J Clin Neurosci. 2018;54:128-35.

Pediatrics145. Bixler GM, Powers GC, Clark RH, Walker

MWW, Tolia VN. Changes in the diagnosis and management of patent ductus arteriosus from 2006 to 2015 in United States neonatal intensive care units. J Pediatr. 2017;189:105-12. PMID: 28600155.

146. Blomquist KK, Griffin SF, Schmalz DL, Sease KK, Reeves CB. Behavioral and psychological predictors of BMI reduction in children seek-ing treatment at a hospital clinic’s family-based pediatric weight management program. J Child Obes. 2018;3(2):10-7.

147. Bruch JS, Stancil MD, Odom JM, Nelson BA. Employee health: diabetes self-management with wireless meter. Diabetes. 2018;67(suppl 1):651P.

148. Buchanan AO. Pediatric nutrition and nutri-tional disorders (5 chapters). In: Marcdante K, Kliegman R, eds. Nelson Essentials of Pedi-atrics. 8th ed. Philadelphia, PA: Elsevier; 2018.

149. Buchanan AO. Gastrointestinal bleeding. In: Zaoutis L, Chiang V, eds. Comprehensive Pe-diatric Hospital Medicine. 2nd ed. New York, NY: McGraw-Hill Education; 2018.

150. Casanova M. Effects of 12 and 18 sessions of rTMS on autonomic activity in autism spec-trum disorder. Appl Psychophysiol Biofeed-back. 2017;42(2):155.

151. Chung E, Gable K, Golden C, Hudson JA, Hackman N, Andrews J, Jackson DA, Beavers J, Mirchandani D, Kellams A, Krevitsky M, Monroe K, Madlon-Kaye D, Stratbucker W, Campbell D, Collins J, Rauch D. Current scope

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2018 PUBLICATIONS

of practice for newborn care in non-intensive hospital settings. Hosp Pediatr. 2017;7(8):471-82. PMID: 28694290.

152. Crowder J, Asif I, Reeves CB, Blomquist K, Brackbill E, Utecht L, Griffin S, Schmalz D, Sease KK, Nelson V. Exercise programming correlates with patient success in a compre-hensive pediatric weight loss program. Clin J Sport Med. 2018;28(2):239-48.

153. Gade AR, Patel M, West DR, Abrams G. Prev-alence of HCV infection in adults with con-genital heart disease and treatment with direct antiviral agents. South Med J. 2018;111(3):137-41. PMID: 29505646.

154. Grisham M. Iron deficiency anemia. Focus Pediatr. 2018;30(1):18-9.

155. Hasan SU, Potenziano J, Konduri GG, Perez JA, Van Meurs KP, Walker MWW, Yoder BA. Effect of inhaled nitric oxide on survival with-out bronchopulmonary dysplasia in preterm infants: a randomized clinical trial. JAMA Pediatr. 2017;171(11):1081-9. PMID: 28973344.

156. Helsel BC, Williams JE, Lawson K, Liang J, Markowitz JE. Telemedicine and mobile health technology are effective in the management of digestive diseases: a systematic review. Dig Dis Sci. 2018;63(6):1392-408.

157. Hintze JP, Edinger JD. Hypnotic discontin-uation in chronic insomnia. Sleep Med Clin. 2018;13(2):263-70.

158. Huang KZ, Jensen ET, Chen HX, Landes LE, McConnell KA, Almond MA, Johnston DT, Durban R, Jobe L, Frost C, Donnelly S, Antonio B, Safta AM, Quiros JA, Markowitz JE, Dellon ES. Practice pattern variation in pediatric eosinophilic esophagitis in the Car-olinas EoE Collaborative: a research model in community and academic practices. South Med J. 2018;111(6):328-32. PMID: 29863219.

159. Jasser S, Foster N, Nelson BA, Kittelsrud J, Di-Meglio L, Quinn M, Willi S, Simmons J. Sleep in children with type 1 diabetes and their parents in T1D exchange. Sleep Med. 2017;39:108-15.

160. Johnson S, Trejo G, Beck KL, Worsley C, Tranberg H, Plax KL, Linton JM. Building community support using a modified World Café method for pregnant and parenting teenagers in Forsyth County, North Carolina. J Pediatr Adolesc Gynecol. 2018;31(6):614-9. PMID: 29960076.

161. Jordan M, Stoichita A, Hudson JA. Choosing high-value care in the evaluation and treatment of newborns at risk for early-onset sepsis. GHS Proc. 2017;2(2):94-5.

162. Kelly DP. Sensory impairments: hearing and vision. In: Macias M, ed. Developmental and Behavioral Pediatrics. 2nd ed. American Academy of Pediatrics; 2018.

163. Kelly DP, Sokhadze EM, Casanova E, Kha-chidz I, Wang Y, Li X. Application of ERPs in autism research and as functional outcomes of neuromodulation treatment. Int J Med Bio Frontiers. 2017;23(2):168-211.

164. Khosla S, Deak MC, Gault D, Goldstein CA, Hwang D, Kwon Y, O’Hearn D, Schutte-Ro-din S, Yurcheshen M, Rosen IM, Kirsch DB, Chervin RD, Carden KA, Ramar K, Aurora RN, Kristo DA, Malhotra RK, Martin JL, Ol-son EJ, Rosen CL, Rowley JA. Consumer sleep technology: an American Academy of Sleep Medicine position statement. J Clin Sleep Med. 2018;14(5):877-80. PMID: 29734997.

165. Linton JM, Stockton MP, Andrade B, Daniel S. Integrating parenting support within and beyond the pediatric medical home. Global Pediatr Health. 2018;5:2333794X18769819. PMID: 29761138.

166. Linton JM, Reichard E, Peters A, Albertini LW, Miller-Fitzwater A, Poehling K. Enhanc-ing resident education and optimizing care for children with special health care needs in resident continuity clinics. Academic Pediatr. 2018;18(4):366-9. PMID: 29269030.

167. Linton JM. The child witness in the court-room. Pediatrics. 2017;139(3).

168. Linton JM. The Community Pediatrics Train-ing Initiative project planning tool: a practical approach to community-based advocacy. MedEdPORTAL. 2017;13:10630.

169. Makhija P, Wilson C, Garimella S. Utility of Doppler sonography for renal artery stenosis screening in obese children with hypertension. J Clin Hypertens. 2018;20(4):807-13. PMID: 29575497.

170. Mann-Jackson L, Song EY, Tanner AE, Alonzo J, Linton JM, Rhodes SD. The health impact of experiences of discrimination, violence, and immigration enforcement among Latino men in a new settlement state. Am J Men’s Health. 2018 Jun 1:1557988318785091. PMID: 29962271.

171. Markowitz JE. Attitudes and beliefs about the use of mobile technology to improve the self-management and patient-provider commu-nication among a sample of pediatric patients with eosinophilic esophagitis. J SC Med Assoc. 2071;113(4):148-51.

172. Markowitz JE. Safety and efficacy of reslizum-ab for children and adolescents with eosino-

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40 GHS Proc. December 2018; 3 (1): 31-46

philic esophagitis treated for nine years. J Pe-diatric Gastroenterol Nutr. 2018;66(6):893-7.

173. Markowitz JE. Pediatric Inflammatory Bowel Disease. 3rd ed. New York, NY: Springer; 2017.

174. Markowitz JE, Clayton SB. Eosinophilic esophagitis in children and adults. Gastrointest Endosc Clin North Am. 2018;28(1):59-75.

175. Merritt M, Kline H, Seigler RS, Garimella S. Pseudohyperkalemia in a patient with T-cell acute lymphoblastic leukemia and hyperleu-kocytosis. J Pediatr Intensive Care. 2018;DOI 10.1055/s-0038-1624569.

176. Michael L, Brady AK, Russell G, Rhodes SD, Namak S, Cody L, Vasquez A, Caldwell A, Foy J, Linton JM. Connecting refugees to med-ical homes through multi-sector collaboration. J Immigrant Minority Health. 2018 May 16. PMID: 29767402.

177. Nelson BA, Williams J, Helsel B, Eke R. Exercise considerations for type 1 and type 2 diabetes. ACSM’s Health and Fitness J. 2018;22(1):10-6.

178. Nunley SR, Glynn P, Rust S, Vidaurre J, Albert DVF, Patel AD. Healthcare utiliza-tion characteristics for intranasal midazol-am versus rectal diazepam. J Child Neurol. 2018;33(2):158-63. PMID: 29233042.

179. Saul RA, Garner AS. Thinking Developmen-tally: Nurturing Wellness in Childhood to Promote Lifelong Health. Itasca, IL: American Academy of Pediatrics; 2018.

180. Singh A, Klick JC, McCracken CE, Hebbar KB. Evaluating hospice and palliative medi-cine education in pediatric training programs. Am J Hospice Palliative Care. 2017;34(7):603-10. PMID: 27122617.

181. Sokhadze G, Casanova MF, Kelly DP, Sokha-dze EM. Effects of 12 and 18 sessions of rTMS on autonomic activity in autism spectrum disorder. Appl Psychophysiol Biofeedback. 2017;42(2):155.

182. Summey J, Chen L, Mayo R, Charron E, Hud-son JA, Sherrill W, Dickes L. Early treatment for opioid-dependent newborns in South Caro-lina improves health outcomes: a retrospective comparison with traditional care, 2006-2014. Joint Commission J Quality Patient Safety. 2018;44(6):312-20. PMID: 29793880.

183. Tamborlane WV, Cheng P, Gal RL, Kollman C, Van Name MA, Lynch JL, Nelson BA. T1D and T2D youth in the Pediatric Diabetes Con-sortium (PDC) Registries: comparing clinical characteristics and glycemic control. Diabetes. 2018;67(suppl 1):1340-P.

184. Uwemedimo OT, Monterrey AC, Linton JM. A dream deferred: ending DACA threatens children, families, and communities. Pediatr. 2017;140(6). PMID: 28993446.

185. Wood J, Boyle C, Quinn M, Wong JC, Haller MJ, Nelson BA, Schatz D. Impact of target HbA1c change in pediatric participants in the T1D exchange clinic registry. Diabetes. 2018;67(suppl 1):1373-P.

Psychiatry186. Griffeth B. The successful integration of psy-

chiatry and neurology in a combined clerkship. Acad Psychiatry. 2017;41(4):547-50.

187. Holder S, Warren C., Rogers K, Griffeth B, Peterson E, Blackhurst DW, Ochonma C. In-voluntary processes: knowledge base of health care professionals in a tertiary medical center in upstate South Carolina. Community Ment Health J. 2018;54(2):149-57.

188. Holder S, Rogers K, Peterson E, Ochonma C. Mental health visits: examining socio-demo-graphic and diagnosis trends in the emergency department by the pediatric population. Child Psychiatry Hum Dev. 2017;48(6):993-1000.

189. Saul JR, Holder S, Lokey JS. Employing the patient-centered collaborative care approach: a case study of a complex geriatric patient with psychopathology of treatment resistant depres-sion and primary hyperparathyroidism. J Ment Health Aging. 2018;2(1):18-23.

Radiology190. Brechtel L, Womack L, Ubah C, Gainey J,

Jain S, Gainey J, Pendergrass J, Faulkner R, Ingiaimo M, Black A, Madeline LA, Troup C, Nathaniel T. Early clinical experience in a year one medical neuroscience course enhances students’ performance. Med Sci Educator. 2018;28(2):315-26.

191. Colello MJ, Ivey LE, Gainey J, Faulkner RV, Johnson A, Brechtel L, Madeline LA, Nathaniel T. Pharmacological thrombolysis for acute ischemic stroke treatment: gender differ-ences in clinical risk factors. Adv Med Sci. 2018;63(1):100-6.

192. Devane AM, Freeman B, Powell B, Hale A, Gandhi S. Traumatic aorto-cisterna chyli fistula with treatment of aortic pseudoaneu-rysm with CT-guided thrombin injection. Ann Vascular Surg. 2018; DOI: 10.1016/j.avsg.2018.02.053.

193. Devane A, Absher J, Madeline L, Rayes S, Webb S. Cerebrovascular disease. In reference module in Neuroscience and Biobehavioral Psychology: Elsevier; 2018.

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41GHS Proc. December 2018; 3 (1): 31-46

2018 PUBLICATIONS

194. Gainey J, Brechtel L, Konklin S, Madeline LA, Lowther E, Blum B, Nathaniel T. In a stroke cohort with incident hypertension; are more women than men likely to be excluded from re-combinant tissue-type Plasminogen Activator (rtPA)? J Neurol Sci. 2018;387:139-46.

195. Gimbel RW, Pirrallo RG, Lowe SC, Wright DW, Zhang L, Woo MJ, Fontelo P, Liu F, Con-nor Z. Effect of clinical decision rules, patient cost and malpractice information on clini-cian brain CT image ordering: a randomized controlled trial. BMC Med Inform Decis Mak. 2018;18(1):20.

196. Nathaniel T, Gainey J, Blum B, Montgomery C, Ervin L, Madeline LA. Clinical risk factors in thrombolysis therapy: telestroke versus nontelestroke. J Stroke Cerebrovascular Dis. 2018;27(9):2524-33.

Surgery197. Beathard GA, Lok CE, Glickman MH, Al-Jai-

shi AA, Bednarski D, Cull D, Lawson JH, Lee TC, Niyyar VD, Syracuse D, Trerotola SO, Roy-Chaudhury P, Shenoy S, Underwood M, Wasse H, Woo K, Yuo TH, Huber TS. Definitions and end points for interventional studies for arteriovenous dialysis access. Clin J Am Soc Nephrol. 2018;13(3):501-12. PMID: 28729383.

198. Beffa LR, Carbonell A. Component separation: robotic approach. In: LeBlanc KA, Kingsnorth A, Sanders DL, eds. Management of Abdomi-nal Hernias. 5th ed. New York, NY: Springer; 2018:423-30.

199. Beffa LR, Margiotta AL, Carbonell A. Flank and lumbar hernia repair. Surg Clinics North Am. 2018;98(3):593-605. PMID: 29754624.

200. Beffa LR, Warren J, Cobb W, Knoedler B, Ew-ing JA, Carbonell A. Open retromuscular repair of parastomal hernias with synthetic mesh. Am Surg. 2017;83(8):906-10. PMID: 28822400.

201. Begley HR, Gray B. Images in vascular medi-cine: the case of the blue-gray fingernails. Vasc Med. 2018;23(3):291-2. PMID: 28697693.

202. Bismuth J, Gray B, Holden A, Metzger C, Panneton J. Pivotal study of a next-generation balloon-expandable stent-graft for treatment of iliac occlusive disease. J Endovascular Ther. 2017;24(5):629-37. PMID: 28697693.

203. Bolton W, Cochran T, Ben-Or S, Stephenson J, Ellis W, Hale A, Binks A. Electromagnetic navi-gational bronchoscopy reduces the time required for localization and resection of lung nodules. Innovations. 2017;12(5):333-7. PMID: 28777130.

204. Bonett A, Shirley SH, Culpepper W. Lower

extremity reconstruction: revisiting the cross-leg flap. GHS Proc. 2017;2(2):148-51.

205. Bunte MC, Cohen DJ, Jaff MR, Gray WA, Magnuson EA, Li H, Feiring A, Cioppi M, Hibbard R, Gray B, Khatib Y, Jessup D, Patar-ca R, Du J, Stoll HP, Massaro J, Safley DM. Long-term clinical and quality of life outcomes after stenting of femoropopliteal artery ste-nosis: 3-year results from the STROLL study. Cathet Cardiovasc Interventions. 2018; DOI: 10.1002/ccd.27569. PMID: 29521013.

206. Carbonell A, Warren J, Prabhu AS, Ballecer CD, Janczyk RJ, Herrera J, Huang LC, Phillips S, Rosen MJ, Poulose BK. Reducing length of stay using a robotic-assisted approach for retromuscular ventral hernia repair: a com-parative analysis from the Americas Hernia Society Quality Collaborative. Ann Surg. 2018;267(2):210-7. PMID: 28350568.

207. Carbonell A. Endorsement of the HerniaSurge guidelines by the Americas Hernia Society. Hernia. 2018;22(1):171. PMID: 29330829.

208. Cull JD, Fleetwood VA, Manning B, Chan EY. Healthcare workers’ attitude toward organ donation at two level 1 urban trauma. Am Surg. 2017;83(9):389-91. PMID: 28958262.

209. Davis JR, Hale A, Ewing JA, Lokey J. Institut-ing ultrasound-guided FNA for thyroid nodules into a general surgery residency program: what we learned. J Surg Education. 2018;75(3):594-600. PMID: 29175058.

210. Erwin PA, Beffa LR, Jones W, Hale A, Scott J. Metallic surgical clip causing cholangitis after cholecystectomy. Am Surg. 2017;83(9):403-5. PMID: 28958267.

211. Fanous M, Warren J, Cobb W. Superiority of Roeder’s knot for fascial mesh fixation in a cadaveric model. Surg Innovation. 2017;24(4):365-8. PMID: 28689486.

212. Fatula LK, Bolton W, Hale A, Davis B, Ste-phenson J, Ben-Or S. Atrial esophageal fistula secondary to ablation for atrial fibrillation: a case series and review of the literature. Innova-tions. 2017;12(4):e3-5. PMID: 28753141.

213. Fox SS, Janczyk R, Warren J, Carbonell A, Pou-lose BK, Rosen MJ, Hope WW. An evaluation of parastomal hernia repair using the Americas Hernia Society Quality Collaborative. Am Sur-geon. 2017;83(8):881-6. PMID: 28822396.

214. Freeman BM, Powell BC, Devane AM, Hale A, Gandhi S. Traumatic aorto-cisterna chlyi fis-tula with treatment of aortic pseudoaneurysm with CT-guided thrombin injection. Annals Vasc Surg. 2018; May 18. PMID: 29778611.

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215. Frykberg RG, Gordon IL, Reyzelman AM, Cazzell SM, Fitzgerald R, Rothenberg GM, Bloom JD, Petersen BJ, Linders DR, Nou-vong A, Najafi B. Feasibility and efficacy of a smart mat technology to predict development of diabetic plantar ulcers. Diabetes Care. 2017;40(7):973-80. PMID: 28465454.

216. Gandhi S, Carsten C. Complex hemodialysis access. In: Rutherford’s Vascular Surgery. 9th ed. London: Elsevier; June 15, 2018.

217. Gandhi S, Cull D. Upper extremity revascu-larization procedures. Online under Vascular Territories in Vasc & Endovasc Surg. 2018.

218. Gandhi S, Ewing JA, Cooper E, Chaves JM, Gray B. Comparison of low-dose catheter-di-rected thrombolysis with and without pharma-comechanical thrombectomy for acute lower extremity ischemia. Annals Vasc Surgery. 2018;46:178-86. PMID: 28739471.

219. Gil D, Rex J, Cobb W, Reukov V, Vertegel A. Anti-inflammatory coatings of hernia repair meshes: a pilot study. J Biomed Materials Res. 2018;106(2):589-97. PMID: 28263435.

220. Goff T, Cull JD. Improved intraoperative communication after utilization of navigational grids during laparoscopic cholecystectomies. Am Surg. 2018;84(5):727-31. PMID: 29966575.

221. Gray B. Updates from the ABVM and SVM. Vascular Med. 2018;23(1):91-2.

222. Hancock BH, Warren J, Marguet C, Carbonell A, Cobb W. Concurrent laparoscopic hernia repair and cystoscopic laser cystolitholax-apy for urinary bladder calculus contained within a direct inguinal hernia. Am Surgeon. 2017;83(9):406-8. PMID: 28958268.

223. Hawkins AT, Ford MM, Benjamin Hopkins M, Muldoon RL, Wanderer JP, Parikh AA, Geiger, TM. Barriers to laparoscopic colon resection for cancer: a national analysis. Surg Endosc. 2018;32(2):1035-42. PMID: 28840352.

224. Hernandez MC, Haddad NN, Cullinane DC, Yeh DD, Wydo S, Inaba K, Duane TM, Pakula A, Skinner R, Rodriguez CJ, Dunn J, Sams VG, Zielinski MD, Choudhry A, Turay D, Yune JM, Watras J, Widom KA, Cull JD, Toschlog EA, Graybill JC. The American Association for the Surgery of Trauma severity grade is valid and generalizable in adhesive small bowel obstruction. J Trauma Acute Care Surg. 2018;84(2):372-8. PMID: 29117026.

225. Hu Q, Shi L, Chen L, Zhang L, Truong K, Ew-ing A, Wu J, Scott J. Seasonality in the adverse outcomes in weight loss surgeries. Surg Obes Related Dis. 2018;14(3):291-6.

226. Hutcheon DA, Hale A, Ewing JA, Miller M, Couto F, Bour E, Cobb WS, Scott J. Short-term preoperative weight loss and postoperative outcomes in bariatric surgery. J Am Coll Surg. 2018;226(4):514-24. PMID: 29402531.

227. Klein AJ, Jaff MR, Gray B, Aronow HD, Ber-sin RM, Diaz-Sandoval LJ, Dieter RS, Drach-man DE, Feldman DN, Gigliotti OS, Gupta K, Parikh SA, Pinto DS, Shishehbor MH, White CJ. SCAI appropriate use criteria for periph-eral arterial interventions: an update. Cathet Cardiovasc Interventions. 2017;90(4):e90-110. PMID: 28489285.

228. Krpata DM, Prabhu AS, Carbonell A, Haskins IN, Phillips S, Poulose BK, Rosen MJ. Drain placement does not increase infectious compli-cations after retromuscular ventral hernia re-pair with synthetic mesh: an AHSQC analysis. J Gastrointest Surg. 2017;21(12):2083-9. PMID: 28983795.

229. Lather HD, Gornik HL, Olin JW, Gu X, Heidt ST, Kim ESH, Kadian-Dodov D, Sharma A, Gray B, Jaff MR, Chi YW, Mace P, Kline-Rog-ers E, Froehlich JB. Prevalence of intracranial aneurysm in women with fibromuscular dysplasia: a report from the US Registry for Fibromuscular Dysplasia. JAMA Neurol. 2017;74(9):1081-7. PMID: 28715558.

230. Leahey A, Bethel S, Summey J, Heavner S. Patient’s perceptions of clinical scribe use in outpatient physician practices. GHS Proc. 2(2):131-6.

231. Lillemoe KD, Klingensmith ME, Darzi A, Tay-lor S. American Surgical Association presiden-tial forum: a lifetime of surgical education: can we do better? Ann Surg. 2017;266(4):555-63. PMID: 28902003.

232. Logghe HJ, McFadden C, Tully NJ, Jones C. History of social media in surgery. Clin Colon Rectal Surg. 30(4):233-9.

233. Low M, Ben-Or S. Thoracic surgery in ear-ly-stage small cell lung cancer. Thorac Surg Clin. 2018;28(1):9-14. PMID: 29150041.

234. Macks C, Gwak SJ, Lynn M, Lee JS. Rolip-ram-loaded polymeric micelle nanoparticle reduces secondary injury after rat com-pression spinal cord injury. J Neurotrauma. 2018;35(3):582-92. PMID: 29065765.

235. Morgan KM, Erwin PA, Rochester SN, Wil-liams CF, Gates RL. Pediatric gastric gangli-oneuroma presenting as anemia. J Pediatric Surg Case Rep. 2018;31:7-9.

236. Namouz T, Carsten C, Hale AL, Walker EJ, Springhart P. A renal arteriovenous malfor-

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2018 PUBLICATIONS

mation case study: the importance of utilizing color Doppler during point-of-care sonography. J Diagn Med Sonography. 34(2):128-31.

237. Nealon SW, Hale A, Haynes E, Hagood-Thomp-son C, Marguet C, Ewing JA, Springhart P. Improving patient outcomes and healthcare provider communication with a small, yellow plastic band: the Patient URinary Catheter Extraction (PURCE) protocol. Urology Pract. 2018;5(1):1-6.

238. Nickloes T, Long C, Mack L, Kallab A, Dunlap A, Gandhi S. Superior vena cava syndrome. Medscape. 2018; Mar 26.

239. Patel PN, Jayawardena ADL, Walden RL, Penn EB, Francis DO. Evidence-based use of periop-erative antibiotics in otolaryngology. Otolaryn-gol Head Neck Surg. 2018;18(5):783-800. PMID: 29405833.

240. Patel PN, Arambula AM, Wheeler AP, Penn EB. Post-tonsillectomy hemorrhagic outcomes in children with bleeding disorders at a single institution. Int J Pediatr Otorhinolaryngol. 2017 Sep;100:216-22. PMID: 28802375.

241. Pingree CS, Majors JS, Howard NS, Eller RL. Laryngocardiac reflex: a case report and review of the literature. J Voice. 2018;32(5):633-5. PMID: 29079124.

242. Postlewait LM, Ethun CG, McInnis MR, Mer-chant N, Parikh AA, Idrees K, Isom CA, Haw-kins W, Fields RC, Strand M, Weber SM, Cho CS, Salem A, Martin RCG, Scoggins C, Bentrem D, Kim HJ, Carr J, Ahmad S, Abbott D, Wilson GC, Kooby DA, Maithel SK. The hand-assisted laparoscopic approach to resection of pancre-atic mucinous cystic neoplasms: an underused technique? Am Surg. 2018;84(1):56-62. PMID: 29428029.

243. Poulose BK, Harris DA, Phillips S, Janczyk RJ, Yunis J, Voeller GR, Carbonell A, War-ren J, Stoikes N, Webb D, Hope WW, Rosen MJ. Reducing early readmissions after ven-tral hernia repair with the Americas Hernia Society Quality Collaborative. J Am Coll Surg. 2018;226(5):814-24. PMID: 29428233.

244. Powell B, Bolton W. Management of lung cancer with concomitant cardiac disease. Thorac Surg Clin. 2018;28(1):69-79. PMID: 29150039.

245. Schneider AM, Manning B, Bolton W. Rare cause of pneumopericardium in a patient following a motor vehicle collision. Am Surg. 2017;83(8):305-7. PMID: 28822369.

246. Schneider AM, Disbrow DE, Ewing JA, Rex J. Laparoscopic management of appendiceal mucoceles. GHS Proc. 2017;2(2):144-7.

247. Schneider A, Hutcheon DA, Hale A, Ewing JA, Miller M, Scott J. Postoperative outcomes in bariatric surgical patients participating in an insurance-mandated preoperative weight management program. Surg Obes Related Dis. 2018;14(5):623-30. PMID: 29525261.

248. Scott J, Morton JM. Advocacy for bariatric and metabolic surgery. Curr Surg Rep. 2018;6:17.

249. Shi L, Scott J, Truong K, Qingwei H, Ewing A, Chen L, Zhang L. Changes in utilization and peri-operative outcomes of bariatric surgery in a large US hospital database, 2011-2014. PLoS One. 2017;12(10):e0186306. PMID: 29053709.

250. Slovut DP, Gray B, Saiar A, Bates MC. Ev-idence-based medicine and contemporary certification: analysis of the American Board of Vascular Medicine endovascular board exam-ination. Vasc Med. 2017;22(4):337-42. PMID: 28594284.

251. Snyder RA, Hu CY, Cuddy A, Francescatti AB, Schumacher JR, Van Loon K, You YN, Kozower BD, Greenberg CC, Schrag D, Venook A, McKellar D, Winchester DP, Chang GJ. Association between intensity of posttreatment surveillance testing and detection of recur-rence in patients with colorectal cancer. JAMA. 2018;319(20): 2104-15. PMID: 29800181.

252. Snyder RA, Prakash LR, Nogueras-Gonzalez GM, Kim MP, Aloia TA, Vauthey JN, Lee JE, Fleming JB, Katz MHG, Tzeng CD. Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis. J Surg Oncol. 2018;117(8):1648-54. PMID: 29723419.

253. Snyder RA, Vauthey JN. Hepatobiliary Can-cers. In: Feig BW, Ching CD, Roland C. eds.: Wolters Kluwer; June 23, 2018. The MD An-derson Surgical Oncology Handbook. Wolters Kluwer; June 23, 2018. Chapter 13.

254. Sprunger H, Carbonell A, Marguet C, Cobb W, Warren J, Flanagan W. Staged manage-ment of giant inguinoscrotal hernia. Am Surg. 2018;84(3):e114-6. PMID: 29559042.

255. Warren J, Stoddard C, Hunter AL, Horton AJ, Atwood C, Ewing JA, Pusker SH, Cancellaro VA, Walker KB, Cobb W, Carbonell A, Morgan RR. Effect of multimodal analgesia on opioid use after open ventral hernia repair. J Gastroin-test Surg. 2017;21(10):1692-9. PMID: 28808868.

256. Warren J, Love M. Incisional hernia repair: minimally invasive approaches. Surg Clin North Am. 2018;98(3):537-59. PMID: 29754621.

257. Warren J, Beffa LR, Carbonell A, Cull JD, Sinopoli B, Ewing JA, McFadden C, Crockett J,

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Cobb W. Prophylactic placement of permanent synthetic mesh at the time of ostomy closure prevents formation of incisional hernias. Sur-gery. 2018;163(4):839-46. PMID: 29224706.

258. Warren J, McGrath SP, Hale A, Ewing JA, Carbonell A, Cobb W. Patterns of recur-rence and mechanisms of failure after open ventral hernia repair with mesh. Am Surg. 2017;83(11):1275-82. PMID: 29183531.

259. Warren J, Carbonell A. Robotic repair of upper abdominal hernias. In: Abdallah ed. Robotic Surgery for Abdominal Wall Hernia Repair: A Manual of Best Practices. New York, NY: Springer Publishing; 2017;21-34.

260. Zielinski MD, Haddad NN, Cullinane DC, Inaba K, Yeh DD, Wydo S, Turay D, Pakula A, Duane TM, Watras J, Widom KA, Cull JD, Rodriguez CJ, Toschlog EA, Sams VG, Hazelton JP, Graybill JC, Skinner R, Yune JM. Multi-institutional, prospective, observational study comparing the Gastrografin challenge versus standard treatment in adhesive small bowel obstruction. J Trauma Acute Care Surg. 2017;83(1):47-54. PMID: 28422909.

Academy for Leadership & Professional Development261. Salas E, Vessey B, Landon L. Temporal Dynam-

ics in Multiteam Systems: An Integrative Perspec-tive for Future Research and Practice. Bingley, UK: Emerald Publishing; 2017:288-322.

262. Shuffler Porter ML, DiazGranados D, May-nard T, Salas E. Developing, sustaining, and maximizing team effectiveness: an integra-tive, dynamic perspective of team devel-opment interventions. Acad Manage Ann. 2018;12(2):688-724.

263. Shuffler ML, Kramer WS, Carter D, Thayer A, Rosen M. Leveraging a team-centric approach to diagnosing multiteam system function-ing: the role of intrateam state profiles. Hum Resource Manage Rev. 2017 Aug. http://dx.doi.org/10.1016/j.hrmr.2017.08.003.

USC School of Medicine Greenville: Biomedical Sciences Faculty, Staff & Students264. Abdel Meguid EM, Khalil M. Measuring

medical students’ motivation to learning anat-omy by cadaveric dissection. Anat Sci Educ. 2017;10(4):363-71. PMID: 27925681.

265. Angermayer ME, Chosed RJ, Roudebush WE. Platelet-Activating Factor protects early embryos from apoptosis. Reprod Sci. 2018;25(suppl 1):245A.

266. Basinger J, Fiester SE, Fulcher JW. Methicil-lin-resistant Staphylococcus aureus parotitis leading to mortality in an adolescent male. Am J Forensic Pathol. 2018;39(3):257-60.

267. Bonds CL, Roudebush W, Lessey B. Sperm motility index and intrauterine insemi-nation pregnancy outcomes. GHS Proc. 2017;2(2):125-30.

268. Emoto C, Johnson T, McPhail B, Vinks AA, Fukuda T. Using a vancomycin PBPK model in special populations to elucidate case-based clini-cal PK observations. CPT Pharmacometrics Sys Pharmacol. 2018;7(4):237-50. PMID: 29446256.

269. Gainey J, Wormack L, Brechtel L, Nathaniel T. Abstract WP89: A functional outcome mod-el for a telestroke-guided tissue plasminogen activator treatment of stroke patients. Stroke. 2018;49(suppl 1):AWP89-AWP89.

270. Harmon KA, Lane BA, Boone RE, Afshari A, Berdel HO, Yost MJ, Goodwin R, Fried-man HI, Eberth JF. Therapeutic engineered hydrogel coatings attenuate the foreign body response in submuscular implants. Ann Plastic Surg. 2018;80(suppl 6):S410-S417. PMID: 29746273.

271. Johnson AB, Montgomery CM, Dillard WA, Morrill K, Hoesli C, Gillette WM, Johnson BK, Nathaniel T. Effect of visual art school-based stroke intervention for middle school students. J Neurosci Nurs. 2017;49(4):214-20.

272. Jones RS, Chang PH, Perahia T, Harmon KA, Junor L, Yost MJ, Fan D, Eberth JF, Good-win R. Design and fabrication of a three-di-mensional in vitro system for modeling vascular stenosis. Microsc Microanalysis. 2017;23(4):859-71. PMID: 28712382

273. Kay D, Teal C, Crites G, Berry A, Hurtubise L, Hall E, Khalil M. “Being there”: building productive scholarly teams across distance and over time. J Reg Med Campuses. 2018;1(2).

274. Kennedy AB, Hales S. Tools clinicians can use to help patients get active. Curr Sport Med Rep. 2018;17(8):271-6. PMID: 30095547.

275. Kennedy AB, Cambron J, Dexheimer J, Trilk J, Saunders RP. Advancing health promotion through massage therapy practice: a cross-sec-tional survey study. Prev Med Rep. 2018 Sep;11:49-55. PMID: 29984138.

276. Kennedy AB, Patil N, Trilk J. “Recover quicker, train harder, and increase flexibility”: Massage therapy for elite paracyclists, a mixed methods study. Br Med J Open Sports Exerc Med. 2018;4(1):e000319. PMID: 29387449.

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277. Kennedy AB, Lavie CJ, Blair SN. Fitness or fatness: which is more important? JAMA. 2018;319(3):231-2. PMID: 29340689.

278. Khalil M, Abdel Meguid EM, Elkhider IA. Teaching of anatomical sciences: a blended learning approach. Clin Anat. 2018;31(3):323-9.

279. Khalil M, Hawkins HG, Crespo L, Bug-gy J. The design and development of pre-diction models for maximizing students’ academic achievement. Med Sci Educator. 2018;28(1):111-7. PMID: 29352730.

280. Khalil M, Williams S, Gregory Hawkins H. Learning and study strategies correlate with medical students’ performance in anatomical sciences. Anat Sci Education. 2018;11(3):236-42.

281. Lane BA, Harmon KA, Goodwin R, Yost MJ, Shazly T, Eberth JF. Constitutive modeling of compressible type-I collagen hydrogels. Med Eng Phys. 2018;53:39-48. PMID: 29396019.

282. Longan E, Knutsen M, Shinkle J, Chosed R. Adapting a photochemical reactor to the study of UV ecology in vineyard yeast. Am J Enol Vitic. 2017;68(4):499-503.

283. Morgan KM, Northey EE, Khalil M. The ef-fect of near-peer tutoring on medical students’ performance in anatomical and physiological sciences. Clin Anat. 2017;30(7):922-8. PMID: 28726243.

284. Nathaniel T, Gainey J, Wormack L, Ubah C, Brechtel L, Frazier A. Abstract P532: Hypertension and gender differences in acute ischemic stroke patients treated with rtPA. Hypertens. 2018;70(suppl 1):AP532.

285. Nathaniel T, Gainey JC, Williams JA, Stewart BL, Hood MC, Brechtel LE, Faulkner RV, Pendergrass JS, Black LA, Griffin SK, et al. Impact and educational outcomes of a small group self-directed teaching strategy in a clinical neuroscience curriculum. Anat Sci Education. 2017;11(5):478-87.

286. Nathaniel T, Stewart B, Williams J, Hood M, Imeh-Nathaniel A. A new insight into the abili-ty to resist ischemic brain injury: does hiberna-tion matter? An editorial comment for “Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux.” J Neurochem. 2017;142(1):10-3.

287. Ohneck EJ, Arivett BA, Fiester SE, Wood CR, Metz ML, Simeone GM, Actis LA. Mucin acts as a nutrient source and a signal for the differ-ential expression of genes coding for cellular

processes and virulence factors in Acineto-bacter baumannii. PLoS ONE. 2018;13(1): e0190599.

288. Olaleye T, Muse W, Adekanbi S, Isang D, Ala-bi I, Imeh-Nathaniel A, Nathaniel T. Biological effects of petiveria alliacea and flueggae virosa on the life cycle of a disease vector. Asian Pacific J Tropical Dis. 2017;5(1):45-51.

289. O’Rourke MA, O’Rourke MC, Hudson MF. Reasons to reject physician assisted sui-cide/physician aid in dying. J Oncol Pract. 2017;13(10):683-6.

290. Pendergrass J, Stewart B, Williams K, Buggy J, Black A, Jain S, Hughes M, Troup C, Na-thaniel T. Integration of patients into first-year neuroscience medical curriculum. Health Professions Education. 2018;4(1):59-66.

291. Polk SR, Stafford C, Adkins A, Effird J, Colello M, Nathaniel T. Contraindications with recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke population. Neurol Psychiatry Brain Res. 2018;27:6-11.

292. Rotimi OR, Kuku O, Kalu N, Oni O, Nwabueze C, Nathaniel T, Zheng S, et al. Association between smoking and functional outcome in acute ischemic stroke population treated with tissue plasminogen activator. Clin Epidemiol Commons. 2018 Apr.

293. Rule KN, Chosed RJ, Chang TA, Robinson RD, Wininger JD, Roudebush WE. Blastocoel cell-free DNA, a marker of embryonic quality. Fertil Sterility. 2017;103(3)(suppl):e106.

294. Rule KN, Chosed RJ, Chang AT, Wininger JD, Roudebush W. Relationship between blastocoel cell-free DNA and day-5 blastocyst morpholo-gy. J Assist Reprod Genet. 2018;35(8):1497-501.

295. Rule KN, Chosed RJ, Chang AT, Wininger JD, Roudebush W. Blastocoel cell-free DNA, a marker of embryonic quality. Fertil Sterility. 2017;108(3):245A.

296. Rumbo-Feal S, Pérez A, Ramelot TA, Arivett BA, Beceiro A, Vallejo JA, Álvarez-Fraga L, Merino M, Ohneck EJ, Fiester SE, Kennedy MA, Actis LA, Bou G, Poza M. Contribution of A. baumannii A1S_0114 gene to the interaction with eukaryotic cells and virulence. Pseudomo-nas and Acinetobacter: From Drug Resistance to Pathogenesis. Frontiers. 2018 Apr;103-116.

297. Russ-Sellers R, Blackwell T. Emergency medical technician training during medical school: benefits for the hidden curriculum. Academic Med. 2017;92(7):958-60. PMID: 28145946.

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298. Shipley AT, Imeh-Nathaniel A, Orfanakos VB, Wormack LN, Huber R, Nathaniel T. The sensi-tivity of the crayfish reward system to mammali-an drugs of abuse. Frontiers Physiol. 2017;8:1007.

299. Wapshott T, Blum B, Kelsey W, Nathaniel T. Investigation of gender differences and exclusive criteria in a diabetic acute ischemic

stroke population treated with recombinant tissue-type plasminogen activator (rtPA). J Vascular Intervent Neurol. 2017;9(6):26.

300. Wright W, Baston K. Use of the NBME basic science subject exams in US medical schools: results of a national survey. Adv Med Educ Pract. 2018 Aug;9:599-604.

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GHS Cancer Institute. World-class therapies where you live.

Video and more at ghs.org/cancerfacts.

19-0094

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December 2018 | Volume 3 | Issue 1

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Special Articles5 A Selection of Abstracts Presented at the 2018 GHS Health

Sciences Center Research Showcase

23 Full List of Abstracts Presented at the 2018 GHS Health Sciences Center Research Showcase

Miscellany29 2018 Greenville Health System Residents and Fellows

30 2018 Graduates of Greenville Health System and University of South Carolina School of Medicine Greenville

31 Publications and Abstracts of Greenville Health System Medical and Scientific Staff, July 2017-June 2018