Optima Cosmetic of Switzerland Darvidis SA

Copyright – Darvidis SA – 1034 Boussens - Switzerland

Table of content

• History

• Vitamin B12 features

• About Vitacreme B12

• Principal actions of Vitacreme B12

• Our products’ line

• Part of clinical study

• Anti-ageing Serum Study report

• Tests on wrinkles caused by age

• Clinical test on sunburns

• World Wide distribution

• Distribution channels

• The Factory

• The Future

History

Vitacreme B12, The first vitamin B12 based cosmetic cream launched on the market

Our company started its distribution activities in Switzerland and abroad in 1999 under the individual

corporate name OPTIMA COSMETIC D. VIETTO. In February 2010 the status of the individual company

changed to be the limited company DARVIDIS SA. It was founded in Switzerland in Boussens, a small village

in Vaud at the heard of our country.

The quality and effectiveness of our products, which is unanimously acknowledged, has allowed the

VITACREME B12 brand to attain the success which it currently enjoys. Interest in the brand has continued

to grow on the export market, particularly in Asian countries and especially in Japan, a country known for

being one of the most difficult markets in the world, where the Regenerative Cream has become one of

the most sold products. The success of our products is continuing to grow in this country, which is the best

representative of the brand in the world. The Japanese success has been echoed in the surrounding

countries and new distributors are interested in the brand.

The formulations comply with the international legislation and cosmetic directives.

Nowadays the VITACREME B12 product range is distributed in the majority of the leading countries

worldwide by means of various distribution channels. These excellent results have encouraged other

countries to distribute the product. The brand is currently known and sold in 30 countries throughout the

world. It is registered in Switzerland under the number IFPI 329924 and internationally under the no. WIPO

873238. VITACREME B12 is recognised and bears the quality label SWISS LABEL.

To date, the brand VITACREME B12 is registered and protected in 35 countries.

Vitamin B12 features

The eutrophic activity of Vitamin B12, administered through general way, is well known.

The pharmacological studies have shown that vitamin B12, when applied in percutaneous application,

increases the elasticity of tissue by promoting the reorganization of the network of elastin fibres and the

production of collagen fibres, thin and regular. This action has the overall effect of “rejuvenation of the skin”.

The result of these pharmacological studies have been corroborated by clinical tests conducted with the

regenerative cream VITACREME B12: very significant reduction of wrinkles and folds of skin, significant

improvements in elasticity and suppleness of the skin, significant correction of dry skin.

About VITACREME B 12

VITACREME B12 was the first cosmetic cream containing Vitamin B12 on the market.

The basic ingredient, guiding of all VITACREME B12 products, is the vitamin B12 (cyanocobalamin). Depending on the product and its application, other valuable active ingredients enriched the formulations for an improved efficiency.

The formulations comply with the international legislation and cosmetic directives. The finished products are tested and under permanent supervision of the Swiss Vitamin Institute.

Principal actions of VITACREME B12

- Anti-wrinkle and anti-ageing. Helps to prevent premature wrinkles, diminishes age lines and reduces existing wrinkles.

- Hydrates and Softens skin tissues after exposure to sun, cold and wind.

- Stimulates renewal of skin cells.

- Revitalizes skin texture and gives new radiance.

- Regains and Improves elasticity and firmness.

- Relieves and Soothes chapped skin.

- In case of burns or after a prolonged exposure to the sun, relieves the burning’s sensation and accelerates the normalisation of the skin.

- Smoothes or Attenuates new or old scars.

Our current products’ line

REGENERATIVE CREAM 50 ml

An exceptional 24 hours care for all types of skin, especially for dry and very dry, tired and dehydrated skins, to

prevent effectively the premature ageing signs, the loss of cutaneous elasticity and suppleness. Its rich and

generous texture re-plumps the skin, moisturizes the top layers of the epidermis and nourishes by bringing the

emollients and lipids necessary to its vitality. Regenerates and soothes damaged and stressed skins. After a

prolonged exposure to the sun, relieves the burning’s sensation and accelerates the normalisation of the skin. The

skin recovers a distinctive comfort and softness, and a unique radiance.

Application :

Every morning and evening, apply on thoroughly cleansed and toned face and neck. Massage with delicate circular

movements until complete absorption. For an intensive radiant programm, apply before the cream, the ANTI-

AGEING SERUM of the Vitacreme B12 skincare line.

Main active ingredients :

Corn (zea mays) oil, salicylic acid, cyanocobalamin (vitamin B12),

allantoin

BODY MILK 200 ml

This essential care for the body stimulates the renewal of the tissue’s metabolism and restitutes firmness to the

supporting cutaneous structures, thanks to its tensing effect conferred by the firming, toning and energizing

agents. It nourishes , improves the skin’s suppleness and elasticity, favours the restructuration of the epidermis,

prevents effectively the tissue slackening and ensures an optimal hydration. The constant and regular use of this

care preserves the skin’s youth and sweetness.

Application :

Morning and/or evening, after bath or shower. Apply on the body and massage with circular and ascending

movements until complete absorption.

Main active ingredients :

corn oil (corn zea mays), salicylic acid, hyaluronic acid, vitamin B12,

allantoin, squalane, glycerin.

ANTI-AGEING SERUM 30 ml

A cocktail of extra concentrated active agents to efficiently fight against wrinkles and fine lines. It contains

valuable vitamins specially selected for their reparative and regenerative properties. It is intended for local use,

particularly for the treatment of "crow's feet" and facial expression wrinkles. Its effect is clearly visible from the

first application, the skin is renewed and softer and the complexion is more radiant. It is the perfect addition to

the Regenerative Cream. Suitable for all types of skin, particularly for mature and devitalized ones.

Application :

Morning and evening, apply on thoroughly cleansed and toned face and neck. Massage delicately until

complete absorption. Then, apply the Regenerative Cream or the Lightening Beauty Cream of the Vitacreme

B12 skin care line, or your usual day or night care. Can be applied at all times of the day or evening for an

immediate « coup d’éclat ».

Main active ingredients :

Hydrolyzed wheat proteins (triticum vulgare), allantoin,

niacinamide (vitamin B3), hyaluronic acid, cyanocobalamin

(vitamin B12), acetyl hexapeptides-8, milk protein complex,

Centella asiatica extract.

LIGHTENING BEAUTY CREAM 50 ml

Our special care is enriched with UVA and UVB filters to protect your skin from sun damages. Its unique

formulation promotes a progressive lightening of the skin, without irritating. It tones down the pigmentation

spots and prevents their development, evens the complexion and gives the skin a new luminosity and radiance.

The skin will be visibly more radiant, the complexion more uniform an clear.

Application :

Morning and/or evening, apply on cleansed face and neck. Massage delicately until complete absorption. For an

intensive radiant programme, apply before the cream, the ANTI-AGEING SERUM of the Vitacreme B12 skincare

line.

Main active ingredients :

Licorice extract (glycyrrhiza glabra), niacinamide (vitamin B3),

salicylic acid, allantoin, cyanocobalamin (vitamin B12),

alpha-arbutin, ascorbyl tetraisotearate(vitamin C), glycirrhetic acid,

UVA-UVB filters, squalane.

VITA EYE & LIP BALM 15 ml

Moisturizes and protects. This non greasy balm is an intense care which protects and soothes the fragile and

sensitive areas of the eyes and lips. Allying the benefits of antioxidant vitamins to UV filters, it avoids the

dehydration and prevents the premature skin ageing. Formulated from natural beeswax and enriched with

precious vegetable extracts of shea-tree, glycerin and squalane, it is the ideal care to regain a soft and satiny

skin and naturally smooth and soft lips. Extracts of centella asiatica, combined with collagen activating peptides,

also allow an optimal rejuvenating and anti-wrinkle effect.

Application :

On eyes and lips outline as much as necessary.

Main active ingredients :

Shea butter, beeswax, niacinamide (vitamin B3), vitamin E,

cyanocobalamin (vitamin B12), centella asiatica extract,

vitamin C (ascorbyl tetraisostearate), peptide (palmytol tripeptides-7)

UVB-UVA filters, allantoin, provitamin B5 (panthenol), squalane.

DAY CREAM SUN PROTECTION SPF 30+++

Anti-ageing, antioxidant, ultra moisturizing and waterproof, this innovative Day Cream is formulated with an

ideal combination of vitamins (B5, C, E and B12 « cyanocobalamin ») and UVA-UVB solar filters. This unique

combination of active ingredients keeps the skin well moisturized and protects it against the harmful effects of

the sun. Thanks to the antioxidant action of the vitamin E, this beauty cream helps to prevent premature skin

ageing and wrinkles formation caused by sunbeams. Ideal for everyday use, it also protects the skin from

external agressions such as pollution. It’s soothing and nourishing properties helps the skin to recover its

firmness, softness and elasticity.

Application :

Apply every morning as a day care or make-up base, or 15 minutes

before the sun exposure, as much as necessary.

Main active ingredients :

UVA-UVB filters, vitamin E, cyanocobalamin (vitamin B12),

vitamin C (ascorbyl tetraisostearate), allantoin,

provitamin B5 (panthenol).

Cleansing Milk 200 ml

This cleansing milk gently removes make-up and skin impurities. It's suitable for all skin types, even the more

sensitive. It allows a quick and efficient removal of normal as well as waterproof make-up. Its' cleaning agents

were selected for their high quality and purity.

Application :

Use daily to gently cleanse the skin and to remove make-up from the face, neck and décolleté.

For optimum results, follow up by applying

VITACREME B12 Vitalizing Lotion.

Main active ingredients :

Mild cleansing agents, Apricot Kernel Oil, Vitamin B12.

Vitalizing Lotion 200 ml

This Vitalizing Lotion gently eliminates impurities and revitalizes the skin. The active ingredients have been

specially selected for their ability to improve skin's elasticity and tighten its' pores. The natural PH balance of

the skin is preserved. Its application leaves the skin feeling soft and refreshed.

Application :

Apply over face (including eye area) and neck with circular motions. Then apply the Regenerative Cream or the

Lightening Beauty Cream of the Vitacreme B12 skin care line, or your usual day or night care.

Main active ingredients :

Caffeine, allantoin, vitamin B3, Swiss Alps Salt,

Lemon Fruit Distillate (Citrus Medica Limonum),

Lavender Flower Water (Lavandula Angustifolia),

Mentha Piperita Flowe/Leaf Water, Rosa Centafolia Water,

vitamin B12.

Exfoliating Cream 100 ml

The specific action of this care is to improve the skin's appearance by acting on its' superficial layers. It removes

dead skin cells and replaces it with radiant, smooth and rejuvenated skin. The skin is gently cleansed, hydrated

in depth, and regains its vitality. The presence of corn starch mattifies and unifies the skin tone. Cell

regeneration is stimulated to reduce the signs of ageing.

Application :

Apply a thin layer and massage in circular motion for several minutes.

Rinse thoroughly with warm water.

Then apply the Regenerative Cream or the Lightening

Beauty Cream of the Vitacreme B12 skin care line,

or your usual day or night care.

Main active ingredients :

Polyethylene (polythene), Jojoba Esters (Simmondsia Chinensis),

Ethylhexylglycerin, vitamin B12.

Regenerating Mask 100 ml

The active ingredients of this mask provide the skin with a triple action :

• Cleanse : the natural clay absorbs impurities and visibly improves the skins’ aspect.

• Hydrate : The high water content optimizes the skins moisture level and strengthens its natural protection barrier.

• Regenerate : Active ingredients, such as caffeine and vitamin b12, enhance microcirculation and stimulate the skin. This leads to healthier and more relaxed skin and improves its metabolic functions.

Application :

Once to twice a week. Apply a uniform layer on the face,

neck and décolleté, avoiding the eye area, and leave

for 10-15 minutes. Rinse thoroughly after ten minutes

with lukewarm water.

Main active ingredients :

Caffeine, vitamin B3, vitamin B12, Zinc Gluconate,

natural clays.

Sunscreen Cream High Protection SPF 50, 50 ml

This Sunscreen High Protection is formulated with an ideal combination of vitamins (B5, C, E and B129 as

well as UVA-UVB SPF 50+++ sunscreen. This unique combination of active ingredients keeps the skin

hydrated and protects it against harmful effects of the sun. It helps to prevent premature ageing and wrinkles

caused by sun exposure.

Application :

Apply 15 minutes before sun exposure.

Reapply as needed.

Main active ingredients :

Provitamin B5 (panthenol), Ethylhexylglycerin,

vitamin E, vitamin C, vitamin B3 (niacinamide),

vitamin B12, UVA-UVB filters.

Part of the clinical study

The aim of the study is to try and demonstrate in human beings the specific properties of vitamin B12, administrated in skin application, on the elasticity of the skin and on its general eutrophic condition.

The pharmacological studies have shown that vitamin B12, when used in such conditions, increases the elasticity of the integument by promoting the reorganisation of the network of elastin fibres and the production of thin and even collagen fibres.

Criteria set :

- Pigmentation and freckles

- Wrinkles and skin folds

- Elasticity

- Dryness

- Thickness of the skin folds

Part of the clinical study (2)

The statistical analysis, using a pre-formatted programme and analysed by computer, gives the following

results :

Pigmentation / Freckles : there is no valid statistical difference between the areas treated with the B12 cream, the placebo and the untreated areas.

Wrinkles and skin folds : the B12 cream reduces, to a very significant degree, the importance of the wrinkles skin folds, when compared to the placebo and the untreated areas.

Elasticity : the B12 cream significantly improves the elasticity of the skin when compared to the areas treated with the placebo and the untreated areas.

Dryness : the B12 cream corrects, in a very significant manner, the dryness of the skin compared to the areas treated with the placebo and the untreated areas.

Thickness of the skin folds : given the fact that variations between individuals are greater than the variations between groups, the increase in the thickness of the skin folds increases significantly in the areas treated with B12 cream compared with the areas treated with the placebo. This increase is nevertheless not significant in comparison to the untreated areas.

Part of the clinical study (3)

Conclusions

If we take up the conclusions of the pharmacological study which has revealed that Vitamin B12 acts predominantly at

the level of the elastic fibrils, the clinical results that we report are in complete agreement. Moreover, we have been able

to show an improvement, as a result of the use of Vitamin B12, of the hydrophilic skin condition by correcting its initial

dryness.

Vitamin B12, when administrated by percutaneous method, corrects one of the basic stigmas of skin ageing, and

therefore opens up a new way in the preventive as well as the curative areas of skin ageing.

Clinical study carried by the Department of Gerontology Dr. J. Vincendeau Retirement Home of Terre-Nègre, Bordeaux, France

Anti-ageing Serum Study report

Carried out by Dermscan Laboratory

Product : VITACREME B12 ANTI-AGEING SERUM

Date of the study : from September 6 to October 31, 2011

Objectives : to evaluate the anti-wrinkle effect

to illustrate the visual expected effects

to evaluate subjectively its properties, its efficacy, its tolerance and its future use

Kinetics : D0 – D28 – D56 / Methodology : before / after

Application zone : face (focusing on the crow’s feet) and neck

Application frequency : twice daily : in the morning and in the evening

Studied population : 20 persons of female sex, 40 years old and above (between 42 and 65), subject with wrinkles on the crow’s feet

Anti-ageing Serum Study report (2)

RESULTS AND CONCLUSION

Under these study conditions, the product VITACREME B12 anti-ageing serum

AFTER 56 DAYS OF TWICE DAILY USE

induced a smoothing and anti-wrinkle effect characterized by :

• a limit significant decrease in the number of microrelief furrows;

• a limit significant decrease in the number of medium wrinkles;

• a significant decrease in the number of deep wrinkles;

• a significant decrease in the number of total wrinkled surface;

• an anti-wrinkle and smoothing effect was mesured in respectively 70 % et 90 % of the subjects

Anti-ageing Serum Study report (3)

The product was appreciated by the subjects for its properties (easy application and penetration, non sticky effect) and its efficiency. The product leaves the skin moisturized, comfortable, soft, smooth, firm and younger. Improvement in skin aspect, tensor, anti-wrinkle and lifting effects, less visible marks of tiredness, wrinkles and fine lines gummed.

70 % of the subjects would like to continue to use the product and might buy it at the end of the study.

Before After

Tests on wrinkles caused by age

The regenerative cream VITACREME B12 used for these tests was applied daily during 7 weeks, on 100 persons, aged between 20 and 60 years old and over, with dry, mixed and oily skins. The cream penetrated easily neither too greasy nor too dry. The cream is rapidly absorbed and does not make any shine in the sun.

Results of the tests

In 25 % of the cases SPECTACULAR IMPROVEMENT.

Important tightening up of the skin around the neck and the face oval, reduction of the depth of the wrinkles, softer skin and the cheek wrinkles had disappeared.

In 40 % of the cases VISIBLE IMPROVEMENT.

Skin with a satisfactory moisture content, the skin is more elastic with a tightening of the tissues of the neck skin.

In 35 % of the cases IMPROVEMENT IN THE MOISTURE LEVEL of the skin and in the elasticity of the tissues.

IN CONCLUSION, THE RESULTS ARE REMARKABLE. In all cases the action of VITACREME B12 takes effect very rapidly. The effects are clearly visible after the first week of the treatment. The results are most satisfactory concerning the elasticity of the skin tissues and the skin moisture.

In general, the clinical tests confirm a stimulation of the biosynthesis in the connective tissues of the dermis and particularly a stimulating action with a reconstitution of elastin in the intermediate dermo-epidermal zone.

CLINICAL TESTS ON SUNBURNS

ALPINE CAMP ON THE MONT-BLANC

Altitude 2600 metres

Tested persons Instructors of the French Alpine Club (14 participants) Mountain guides Amateur climbers and young trainees

The test results were recorded by the camp’s medical unit (3 doctors)

The skin of the guides and instructors is dry, thick and slightly wrinkled. The injuries are superficial skin lesions caused by overexposure to ultraviolet rays encountered at high altitude. The lesions were aggravated by the climate, time spent on the glaciers, wind and extreme cold at high altitude. The lesions are characterised by sun rashes, possibly with blister and/or desquamation (shedding of skin).

VITACREME B12 was applied on all individuals suffering from skin lesions. After several days of application of VITACREME B12 on

The individuals with light burnt and dry skin : Rapid normalization, skin becomes more supple, desquamation stopped. Feeling of burn rapidly eased, suntan improvement, epidermal moisture level re-established.

The individuals with signs of burnt skin, wrinkled and peeling : Skin had gradual improvement of the smoothness of the skin. Reduction of wrinkles, desquamation stopped, burns soothed.

The individuals who had in advance applied VITACREME B12 for prevention : The treated areas remained soft and moist. No desquamation.

A considerable reduction and/or rapid improvement of the lesions caused by ultraviolet rays was found.

Distribution in America

United States

Chile

Distribution in Asia

China Mainland Pakistan

Hong-Kong

Indonesia

Saudia Arabia

Singapore

Japan Taiwan

Jordan Thailand

Korea (South)

Kuwait

Lybia

Malaysia

Distribution in Europe

Switzerland Slovenia

Danemark Switzerland

Iceland Turkey

France Ukraine

Malta Spain

Romania

Distribution channels

Chain stores (retail stores)

Pharmacies, drug stores, supermarkets

Department stores

Aesthetic salons, beauty salons

TV shopping

The Factory

FCC Fragrances, Cosmetics & Consulting Sàrl

The factory is a Swiss Private Company called FCC Fragrances, Cosmetics & Consulting Sàrl located in Aigle. They

take advantage of the benefits offered by a unique and exceptional environment, which is stimulated by intense

international exchange.

The company is characterized by a variety of high level scientific and technical know-how, efficiency and high

professional awareness, search of perfection, creativity and desire for innovation. The products are perfectly

suited to the different markets in the world. The ingredients used come from the most reliable sources and are

of the highest available purity.

The Factory (2)

FCC Fragrances, Cosmetics & Consulting Sàrl

The method of manufacture, packing and storage used at FCC complies with international manufacturing standards and

CGMP (Cosmetic Good Manufacturing Practices)

laid down by :

Swiss Federal Office of Public Health, Bern, Switzerland

Cantonal Laboratory, Lausanne, Switzerland

Community law (European Council Directive 76/768/EEC)

Colipa (The European Cosmetic and Toiletry Association), Bruxelles, Belgium

IKW (Industrie Körperflege und Waschmittel), Frankfurt am Main, Deutschland.

The Factory (3)

The production (bulk)

The Factory (4)

The packaging

The future

Our aim at middle and long-term, in intimate collaboration with our partners and exclusive distributors all over the world, is to consolidate our distributions’networks and to continue to supply our international clientele with high quality products and novelties with vitamin B12.

Thank you for your kind collaboration

Head Office

Optima Cosmetic of Switzerland

Darvidis SA

Grand-Rue 18, CH-1034 Boussens

Switzerland

Tel: 0041 21 887 66 80 / Fax: 0041 21 887 75 25

E-mail : export@darvidis.ch

Website: www.darvidis.ch