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Dalmo Mendonca February 24, 2011 Why is doing research about meth important? What do we know so far?...
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Transcript of Dalmo Mendonca February 24, 2011 Why is doing research about meth important? What do we know so far?...
Dalmo Mendonca
February 24, 2011
MethamphetamineResearching Signal Transduction
• Why is doing research about meth important?
• What do we know so far?
• What do we want to know?• Hypothesize • Acquire tools & resources• Research!
• How can we use our new findings?
Overview
Importance: Meth
• Cocaine
• PCP (Angel’s Dust)
• Other Amphetamines
• Pharmaceuticals• Anxiolytics• ADD & ADHD medication• Ritalin, Concerta, Adderall, and
Desoxyn
Importance: Similar Drugs
Current Scientific Model
The New Hypothesis• Second messenger cascade
• Possibility of an intermediary protein
• Oxidoreductase?
• DAT Regulation
• Shape-dependent?
• Sensitivity to Phosphorylation
• Mechanism of DAT depletion
• Denaturation?
Research
• Results will reveal more regulatory steps• More pharmaceuticals can interact with more
steps• This leads to better rehabilitation methods
• Understanding meth = understanding Rx• Safer ADD & ADHD medication• Better/More effective anxiolytics and
antidepressants
• For the Future: Safe recreational drug use?
Applications
• notevenonce.com
• utulsa.edu/academics/colleges/College-of-Engineering-and-Natural-Sciences/Departments-and-Schools/Department-of-Chemistry-and-Biochemistry
• ou.edu/content/tulsa.html
• utulsa.edu/academics/colleges/College-of-Engineering-and-Natural-Sciences/Departments-and-Schools/Department-of-Biological-Science.aspx
• ncbi.nlm.nih.gov/pmc/articles/PMC549289
• ncbi.nlm.nih.gov/pmc/articles/PMC368179
• molecularbrain.com/content/2/1/10
Sources & Resources
Questions?