DAFTAR PUSTAKA Bintari Rukmono, Hoedojo, Nani S. Djakaria, Siti Doemilah Soeprihatin, Sri S....

54

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59

Lampiran 1

JADWAL PENELITIAN

Senin Selasa Rabu Kamis Jumat Sabtu Minggu

26 April

Adaptasi

27 April

Adaptasi

28 April

Adaptasi

29 April

Adaptasi

30 April

Adaptasi

1 Mei

Adaptasi

2 Mei

Intervensi

2 Mei

Intervensi

3 Mei

Intervensi

4 Mei

Intervensi

5 Mei

Intervensi

6 Mei

Intervensi

7 Mei

Intervensi

8 Mei

Inokulasi

9 Mei

Intervensi

10 Mei

Intervensi

11 Mei

Intervensi

12 Mei

Intervensi

13 Mei

Intervensi

15 Mei

Intervensi

16 Mei

Terminasi

Cek

parasitemia

60

Lampiran 2

PENGHITUNGAN PERSENTASE PARASITEMIA

Kelompok K

1.

2.

3.

4.

5.

Kelompok P1

1.

2.

3.

4.

5.

Kelompok P2

1.

61

2.

3.

4.

5.

Kelompok P3

1.

2.

3.

4.

5.

62

Lampiran 3

PERUBAHAN BERAT MENCIT

26 – 04 – 2016

K P1 P2 P3

25.6 31.0 26.5 31.2

22.0 24.8 29.0 31.4

29.8 22.2 28.0 30.5

23.5 24.7 29.3 27.0

24.9 26.1 27.8 23.2

01 – 05 – 2016

K P1 P2 P3

26.4 32.3 26.9 33.3

28.6 26 30.1 31.6

31.4 30 29.3 31.0

29.6 26.9 28.2 27.8

25.7 28.1 28.2 27.8

15 – 05 – 2016

K P1 P2 P3

26.2 31.8 27.8 29.7

28.3 27.5 30.7 32.2

26.7 31 26.8 30.1

28.3 26.3 30.5 27.5

27.1 30.0 27.5 22.9

63

Lampiran 4

PENGHITUNGAN INOKULUM

1. Persentase parasitemia =

2. Hitung eritrosit :

a. 995 µl Hayem + 5 µl darah mencit.

b. Campurkan.

c. Masukkan 5µl dalam bilik hitung

d. Hitung dalam 5 bidang tengah.

Jumlah Sel Darah Merah =N

Jumlah Sel Darah Merah 3/mm3 = N x Pengenceran x vol. bidang /mm3

= N x 200 x 10000.

Jumlah N = 314 sel

Jumlah Sel Darah Merah / mm3 = 314 x 10000 = 31,4 x 105

Jumlah Sel Darah Merah / ml = 31.4 x 108

Hitung jumlah P.berghei / ml Indeks parasitemia = 55.4%

Jumlah Sel Darah Merah / ml = 31.4 x 108

Jumlah Plasmodium / ml = ( 55.4 x 10 -2

) x (31.4 x 108)

= 1739.56 x 106

= 173.956 x 107

Pengenceran 0.1 ml = (173.956) x 107

Misal ada 24 mencit = 2400 µl

Darah mencit indukan 1/p x volume yang diperlukan.

64

1/ 173.956 x 2400 µl = 13.8 µl

Pembuatannya = 13.8 µl darah mencit indukan + (2400-13.8)

=13.8 + 2486.2 campur / homogen.

Diambil 0.1 ml disuntikkan ke percobaan

65

Lampiran 5

PERHITUNGAN DOSIS A. MURICATA

Pencegahan : 3 x 1 tablet (1 tablett setara 400 mg ekstrak)

Contoh :

K P1 P2 P3

26.4 32.3 16.9 33.3

28.6 26 30.1 31.6

31.4 30 29.3 31.0

29.6 26.9 29.4 27.8

25.7 28.1 28.2 29.8

Rata – Rata Berat

28.34 28.66 28.78 30.7

Penghitungan Dosis Tiap Kelompok

Kelompok Berat Rata-Rata(mg) Dosis (mg)

K 28.34 4.41

P1 28.66 4.46

P2 28.78 4.47

66

P3 30.7 4.78

Pengobatan

3 x 2 tablet dimana satu tabletnya berisi 400 mg ekstrak daun.

Contoh :

K P1 P2 P3

26.4 32.3 16.9 33.3

28.6 26 30.1 31.6

31.4 30 29.3 31.0

29.6 26.9 29.4 27.8

25.7 28.1 28.2 29.8

Rata – Rata Berat

28.34 28.66 28.78 30.7



K 28.34 8.84

P1 28.66 8.94

67

P2 28.78 8.98

P3 30.7 9.58

68

Lampiran 6

PENGHITUNGAN DOSIS DHP

Contoh : dihydroartemisinin 3 x 1 tablet supra.dengan kandungaan 2 sampai

dengan 4 dihydroartemisinin

Contoh :

K P1 P2 P3

26.4 32.3 16.9 33.3

28.6 26 30.1 31.6

31.4 30 29.3 31.0

29.6 26.9 29.4 27.8

25.7 28.1 28.2 29.8

Rata – Rata Berat

28.34 28.66 28.78 30.7



K 28.34 0,77

P1 28.66 0.78

P2 28.78 0.78

P3 30.7 0.83

69

Lampiran 7

FOTO KEGIATAN PENELITIAN

71

Lampiran 8

HASIL OUTPUT SPSS 16

Descriptive Gabungan

Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent

DATA 20 100.0% 0 .0% 20 100.0%

Descriptives

Statistic Std. Error

DATA Mean 15.6920 1.93547

99% Confidence Interval for

Mean

Lower Bound 10.1547

Upper Bound 21.2293

5% Trimmed Mean 15.2322

Median 13.3000

Variance 74.921

Std. Deviation 8.65569

Minimum 6.36

Maximum 33.30

Range 26.94

Interquartile Range 14.70

Skewness .651 .512

Kurtosis -.926 .992

72

Normalitas Gabungan

Tests of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic Df Sig. Statistic Df Sig.

DATA .176 20 .107 .887 20 .024

a. Lilliefors Significance Correction

73

Descriptive Masing-Masing Kelompok


SCORE

Cases

Valid Missing Total


DATA KONTROL (AIR) 5 100.0% 0 .0% 5 100.0%

PERLAKUAN1 (AM) 5 100.0% 0 .0% 5 100.0%

PERLAKUAN2 (ACT) 5 100.0% 0 .0% 5 100.0%

PERLAKUAN3 (AM +

ACT) 5 100.0% 0 .0% 5 100.0%

Descriptives

SCORE Statistic Std. Error

DATA KONTROL

(AIR)

Mean 26.7000 1.98267

99% Confidence Interval for Mean Lower

Bound 17.5716

Upper

Bound 35.8284


74

Median 26.7000

Variance 19.655


Minimum 22.60

Maximum 33.30

Range 10.70


Skewness .755 .913

Kurtosis -.101 2.000

PERLAKUAN1

(AM)

Mean 17.3800 3.39844


Bound 1.7333

Upper

Bound 33.0267


Median 18.4000

Variance 57.747


Minimum 10.00

Maximum 28.50

Range 18.50


Skewness .625 .913


PERLAKUAN2

(ACT)

Mean 11.1420 1.65230


Bound 3.5347

Upper

Bound 18.7493


Median 12.4000

75

Variance 13.650


Minimum 7.14

Maximum 14.70

Range 7.56


Skewness -.384 .913

Kurtosis -3.093 2.000

PERLAKUAN3

(AM + ACT)

Mean 7.5460 .43940


Bound 5.5229

Upper

Bound 9.5691


Median 7.8800

Variance .965

Std. Deviation .98254

Minimum 6.36

Maximum 8.57

Range 2.21


Skewness -.390 .913

Kurtosis -2.680 2.000

Normalitas Masing-Masing Kelompok

Tests of Normality

SCORE


Statistic df Sig. Statistic df Sig.

DATA KONTROL (AIR) .217 5 .200* .906 5 .443

PERLAKUAN1 (AM) .217 5 .200* .906 5 .445

PERLAKUAN2 (ACT) .253 5 .200* .821 5 .120

76

PERLAKUAN3 (AM +

ACT) .233 5 .200* .891 5 .363


*. This is a lower bound of the true significance.

Homogenitas

Test of Homogeneity of Variances

DATA

Levene Statistic df1 df2 Sig.

3.176 3 16 .053

One Way ANOVA

ANOVA

DATA

Sum of Squares Df Mean Square F Sig.

Between Groups 1055.426 3 351.809 15.293 .000

77

Within Groups 368.071 16 23.004

Total 1423.497 19

Post Hoc

Multiple Comparisons

DATA

LSD

(I) SCORE (J) SCORE

Mean

Difference (I-J) Std. Error Sig.

99% Confidence

Interval

Lower

Bound

Upper

Bound

KONTROL

(AIR)

PERLAKUAN1

(AM) 9.32000* 3.03344 .007 .4600 18.1800

PERLAKUAN2

(ACT) 15.55800* 3.03344 .000 6.6980 24.4180

PERLAKUAN3

(AM + ACT) 19.15400* 3.03344 .000 10.2940 28.0140

PERLAKUAN1

(AM)

KONTROL (AIR) -9.32000* 3.03344 .007 -18.1800 -.4600

PERLAKUAN2

(ACT) 6.23800 3.03344 .056 -2.6220 15.0980

PERLAKUAN3

(AM + ACT) 9.83400* 3.03344 .005 .9740 18.6940

PERLAKUAN2

(ACT)

KONTROL (AIR) -15.55800* 3.03344 .000 -24.4180 -6.6980

PERLAKUAN1

(AM) -6.23800 3.03344 .056 -15.0980 2.6220

PERLAKUAN3

(AM + ACT) 3.59600 3.03344 .253 -5.2640 12.4560

PERLAKUAN3

(AM + ACT)

KONTROL (AIR) -19.15400* 3.03344 .000 -28.0140 -10.2940

PERLAKUAN1

(AM) -9.83400* 3.03344 .005 -18.6940 -.9740

PERLAKUAN2

(ACT) -3.59600 3.03344 .253 -12.4560 5.2640

*. The mean difference is significant at the 0.01 level.

Parasitemia

78


Score

Cases

Valid Missing Total


Data Kontrol 5 100.0% 0 .0% 5 100.0%

Perlakuan1 (AM) 5 100.0% 0 .0% 5 100.0%

Perlakuan2 (ACT) 5 100.0% 0 .0% 5 100.0%

Perlakuan3 (AM+ACT) 5 100.0% 0 .0% 5 100.0%

Descriptives

Score Statistic Std. Error

Data Kontrol Mean 19.8800 2.66391

99% Confidence

Interval for Mean

Lower Bound 7.6151

Upper Bound 32.1449


Median 21.3000

Variance 35.482


Minimum 10.90

Maximum 26.30

Range 15.40


Skewness -.841 .913

Kurtosis .332 2.000

Perlakuan1

(AM)

Mean 18.4000 1.41669


Bound 11.8774

Upper

Bound 24.9226

79


Median 19.0000

Variance 10.035


Minimum 14.40

Maximum 22.80

Range 8.40


Skewness .200 .913

Kurtosis .002 2.000

Perlakuan2

(ACT)

Mean .5500 .06237


Bound .2628

Upper

Bound .8372

5% Trimmed Mean .5556

Median .6000

Variance .019


Minimum .33

Maximum .67

Range .34

Interquartile Range .24

Skewness -1.217 .913

Kurtosis .797 2.000

Perlakuan3

(AM+ACT)

Mean .4120 .06851


Bound .0966

Upper

Bound .7274

5% Trimmed Mean .4133

80

Median .4000

Variance .023


Minimum .20

Maximum .60

Range .40

Interquartile Range .28

Skewness -.253 .913


Tests of Normality

Score


Statistic Df Sig. Statistic df Sig.

Data Kontrol .194 5 .200* .958 5 .793

Perlakuan1 (AM) .188 5 .200* .976 5 .912

Perlakuan2 (ACT) .240 5 .200* .884 5 .326

Perlakuan3

(AM+ACT) .143 5 .200* .987 5 .970


*. This is a lower bound of the true significance.

81


Cases

Valid Missing Total


Data 20 100.0% 0 .0% 20 100.0%

Descriptives

Statistic Std. Error

Data Mean 9.8105 2.25281

99% Confidence Interval for

Mean

Lower Bound 3.3654

Upper Bound 16.2556


Median 5.7850

Variance 101.503

Std. Deviation 1.00749E1

Minimum .20

82

Maximum 26.30

Range 26.10


Skewness .289 .512

Kurtosis -1.779 .992

Tests of Normality


Statistic df Sig. Statistic df Sig.

Data .318 20 0.0000110 .792 20 .001


Ranks

Score N Mean Rank

Data Kontrol 5 16.20

Perlakuan1 (AM) 5 14.80

Perlakuan2 (ACT) 5 6.70

83

Perlakuan3 (AM+ACT) 5 4.30

Total 20

Test Statisticsa,b

Data

Chi-Square 14.848

Df 3

Asymp. Sig. .002

a. Kruskal Wallis Test

b. Grouping Variable: Score

Ranks

ScoreKP1 N Mean Rank Sum of Ranks

KP1 Kontrol(Air) 5 6.20 31.00

Perlakuan 1 (AM) 5 4.80 24.00

Total 10

Test Statisticsb

KP1

Mann-Whitney U 9.000

Wilcoxon W 24.000

Z -.731

Asymp. Sig. (2-tailed) .465

Exact Sig. [2*(1-tailed Sig.)] .548a

a. Not corrected for ties.

b. Grouping Variable: ScoreKP1

Ranks

84


KP2 Kontrol (Air) 5 8.00 40.00

Perlakuan 2 (ACT) 5 3.00 15.00

Total 10

Test Statisticsb

KP2

Mann-Whitney U .000

Wilcoxon W 15.000

Z -2.611





Ranks


KP3 Kontrol (Air) 5 8.00 40.00

Perlakuan 3 (AM+ACT) 5 3.00 15.00

Total 10

Test Statisticsb

KP3

Mann-Whitney U .000

Wilcoxon W 15.000

Z -2.611




85

Test Statisticsb

KP3

Mann-Whitney U .000

Wilcoxon W 15.000

Z -2.611





Ranks

ScoreP1P2 N Mean Rank Sum of Ranks

P1P2 Perlakuan 1 (AM) 5 8.00 40.00

Perlakuan 2 (ACT) 5 3.00 15.00

Total 10

Test Statisticsb

P1P2

Mann-Whitney U .000

Wilcoxon W 15.000

Z -2.611




b. Grouping Variable: ScoreP1P2

Ranks


P1P3 Perlakuan 1 (AM) 5 8.00 40.00

86


Total 10

Test Statisticsb

P1P3

Mann-Whitney U .000

Wilcoxon W 15.000

Z -2.611





Ranks


P2P3 Perlakuan 2 (ACT) 5 6.70 33.50


Total 10

Test Statisticsb

P2P3

Mann-Whitney U 6.500

Wilcoxon W 21.500

Z -1.257





87

Lampiran 8

SURAT – SURAT

97

Lampiran 9

BIODATA MAHASISWA

Identitas

Nama : Dwi Fatimah Sari

NIM : 22010112110186

Tempat/ tanggal lahir : Sorong, 10 – 04 – 1994

Jenis kelamin : Perempuan

Alamat : Jl. Galang Sewu Raya No. 99A Baskoro

Nomor HP : 082199559955

Email : [email protected]

Riwayat Pendidikan Formal

1. SD : SD N 2 Remu Sorong Lulus tahun : 2006

2. SMP : SMP N 9 Kota Sorong Lulus tahun : 2009

3. SMA : SMA N 1 Teras Lulus tahun : 2012

4. FK UNDIP : Masuk tahun : 2012

mailto:[email protected]

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