D4FF55A0-6B6F-4181-8802-07BF422A9BA9What is it?
Precision medicine is an emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle.
The Precision Medicine Initiative will generate the scientific evidence needed to move the concept of precision medicine into clinical practice.
www.nih.gov/precisionmedicine
201520“

Sequencing Improved New tools
genome biomedical analysis datasets
Innovative clinical trials Use of Knowledge to
of targets drugs for combination overcome drug
adult, pediatric cancers therapies resistance
http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic
http://www.cancer.gov/research/key-initiatives/precision-medicine

LONGER TERM GOALS
Create a research cohort of >1 million American volunteers who will share genetic data, biological samples, and diet/lifestyle information, all linked to their electronic health records if they choose
Pioneer a new model for doing science that emphasizes engaged participants, responsible data sharing, and privacy protection.
http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic

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Research based upon the cohort data will:
Advanced pharmacogenomics, the right drug for the right patient at the right dose
Identify new targets for treatment and prevention
Test whether mobile devices can encourage healthy behaviors
Lay scientific foundation for precision medicine for many diseases
http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic

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Ancestry Composition
61.7%37.1%1.2%
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Traits

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WarfarinWarfarinClopidogrel“”
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Inherited condition
Inherited condition23andMe Many of these conditions are recessive, meaning that they only occur when you have two variants for that condition, one inherited from each parent. If you have inherited just one variant, you are said to be a "carrier". Carriers usually do not have the condition, but can pass the variant on to their childrenBRCA
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“These reports provide information about your possible risk for developing certain health conditions based on genetics. Environmental and lifestyle factors also often play a large role in your risk for developing these conditions.”
Health Risk23andMe/These reports provide information about your possible risk for developing certain health conditions based on genetics. Environmental and lifestyle factors also often play a large role in your risk for developing these conditions. “”
Gout2 +
Atrial Fibrillation, 40%it may cause not symptoms, but often associated with palpitations, fainting, chest pain or congestive heart failure. 30no symptoms
23andMeactual riskrelative risk
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Crohn’s Disease5%
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