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Wednesday, October 22, 201412 noon Eastern, 9 a.m. Paciˇc, 5 p.m. UK, 6 p.m. Central Europe

Register Now!webinar.sciencemag.org

Speakers

Jefrey Engelman, M.D., Ph.D.Harvard Medical SchoolBoston,MA

Michael B. Yafe, M.D., Ph.D.Massachusetts Institute ofTechnologyCambridge, MA

During the webinar, viewers will:ï Gain an understanding of the speciˇc molecules and pathways that are the

targets for rationally designed therapies

ï Learn about efforts to overcome resistance to the ˇrst FDA-approved therapy

targeting a hyperactive kinase

ï Review mechanisms by which tumor cells resist inhibitors that target cell

survival and growth pathways

ï Hear how the rewiring of cell death pathways can sensitize cells to traditional

chemotherapy agents

ï Have their questions answered live by the expert panel.

This webinar is the ˇrst in a series focusing on the pathways that allow for cancerdevelopment and progression, the emerging research in identifying and target-ing these pathways, and the innovations in the development of cancer treatmentoptions. Recent advances in our understanding of cancer have revealed thatthe disease cannot be understood through simple analysis of genetic mutationswithin cancerous cells. Instead, tumors should be considered complex tissuesin which the cancer cells evolve and communicate with the surrounding cellularmicroenvironment to promote their own survival and dissemination. Althoughtherapies against speciˇc signaling proteins or pathways have been remarkablysuccessful at treating certain cancers, the tumors frequently develop resistance,leading to even more aggressive forms of the disease.

This webinar will focus on how rewiring of signaling pathways in response todrug treatment contributes to resistance and how this knowledge can be lever-aged to develop more effective treatment strategies.

Michael W. Deininger, M.D., Ph.D.University of UtahSalt Lake City, UT

Brought to you by theScience/AAAS Custom

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Webinar sponsored by

Part 1: TargetingCancer PathwaysTumor Resistance

Webinar

1638 26 SEPTEMBER 2014 • VOL 345 ISSUE 6204 sciencemag.org/products SCIENCE

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