Cytopathology of lesions in bone
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Transcript of Cytopathology of lesions in bone
Cytopathology of Osteolytic Lesions in Bone
Dr Genevieve Warner Learmonth
Cytopathologist / Histopathologist,Cytopathology Laboratory, Groote Schuur HospitalUniversity of Cape Town
Lytic lesions in Bone Lytic lesions are easily aspirated using a
Jam Shedi needle. Most lytic lesions in bone are metastatic
tumours. However infectious lesions of bone due to
Tuberculosis and opportunistic infections due to HIV/AIDS are becoming more common in South Africa.
Metabolic diseases can also present as lytic lesions in bone
Bony lesion: A shepherdess aged 60 years has difficulty in walking.
X Ray: knee joint destroyed.
Clinical Diagnosis: ?Aneurysmal Bone Cyst.Jam Shedi needle aspirated clear fluid for Cytology.
Clear Fluid with scanty translucent hooklets and laminated membrane
Clinical Impression:
Note extensive involvement of tibia, fibula, knee joint space, patella and soft tissues.
No clinical signs of inflammation
No sinus formation No pain No clinical evidence of
parathyroid dysfunction. No renal disease
Lytic lesion in Clavicle. Scolices and Rostellum of hooklets
Histology of lytic lesion in clavicle, cross section of scolex, and laminated membrane
Life cycle of Echinococcus granulosus in South Africa
A wolf in sheep’s clothing
TUBERCULOSIS in BONE
35 year old woman presents with pain in lumbar area for months, then sudden paraplegiaX-rays show lytic lesions in lumbar vertebraeJam Shedi needle aspirate yields necrotic material.Cytology: Papanicolaou stain
Collapse of spine with Kyphosis
Necrotising Inflammation, no evidence of granulomata
Rare Langhan’s cell
Ragged fragments of bone
TB bacilli, ZN stain and autofluorescence with Papanicolaou stain using LED
Histology ---Necrotising inflammation. No granulomata.
Drug-susceptible TB and MDR-TB are spread the same way. TB germs are put into the air when a person with TB disease of the lungs or throat coughs, sneezes, speaks, or sings. These germs can float in the air for several hours, depending on the environment. Persons who breathe in the air containing these TB germs can become infected.
TB and HIV ---the terrible twins
When screening a slide, note carefully what you observe, no matter how odd it may seem
Difficult to reach with health services