35th International Society for Heart Research

North American Section Meeting

“NOVEL STRATEGIES TO COMBAT HEART FAILURE”

May 12 -15, 2014

Miami Beach, Florida

Program Co - Chair: Joshua M. Hare and Michael S. Kapiloff

International Society for Heart Research - North American Section

President: Elizabeth Murphy

President-Elect: Steve R. Houser

Past -President: Donald M. Bers

Secretary: Jennifer Van Eyk

Treasurer: Litsa Kranias

Executive Secretary: Leslie Anderson Lobaugh

American section web site:www.american.ishrworld.org

International web site:www.ishrworld.org

Council Members 2009 -15Mark AndersonSusan HowlettCharles MurryJeff RobbinsHoward RockmanMark SussmanJil TardiffYibin Wang

Sarah Franklin ECI representative (2012-14)Gao Chen ECI representative (2013-2015)

Council Members 2012 -18Chris BainesPieter de TombeAsa GustaffsonJoan Heller BrownTimothy KampWalter KochGary LopaschukJun Sadoshima

Early Career Investigator CommitteeSarah Franklin, ChairGrant BudasGao ChenSam DasAlice HoMark Kohr

Maggie LamChris MurrayRandi ParksCatherine PassarielloSakthi Sadayappan

Senior Advisors: Jeff Robbins, Litsa Kranias and Chris Baines

Acknowledgements

Thank you to our Sponsors

The Interdisciplinary Stem Cell InstituteUniversity of Miami Miller School of Medicine

Heart Genomics

Cardiovascular Research Center & Center for Translational MedicineTemple University School of Medicine

VisualSonics

Med Lab Supply Company/Siemens

The Heart Instituteat Cincinnati Children’s

Educational Grant Provided By Gilead

Special Thanks to Our Meeting Organizers:

Meeting Secretariat: Katie Campbell

Conference Planner: Roselyn Robbins

Executive Secretary: Leslie Anderson Lobaugh

Monday May 12, 2014

Overview

7:00 AM 6:00 PM Speaker Ready Room Regency Conference Room8:00 AM 5:00 PM Registration Grande Promenade Foyer9:00 AM 11:00 AM NAS Section Council Meeting Miramar North9:00 AM 10:30 AM ECI Symposium Regency Ballroom10:30 AM 10:45 AM Coffee Break Regency Ballroom10:45 AM 11:45 AM Alternative Science Career Paths Regency Ballroom12:00 PM 1:00 PM ECI Lunch with Senior investigators Starlight Ballroom1:00 PM 2:30 PM Interest Group 1 Grande Promenade1:00 PM 2:30 PM Interest Group 6 Regency Ballroom2:30 PM 3:00 PM Coffee Break Grande Promenade3:00 PM 4:30 PM Interest Group 3 Grande Promenade3:00 PM 4:30 PM Interest Group 7 Regency Ballroom4:30 PM 6:30 PM Young Investigator Competitions Grande Promenade6:30 PM 8:00 PM Reception Starlight Ballroom

9:00AM – 10:30 AM ECI SymposiumChair: Randi Parks and Samarjit DasCatherine Passariello - Disruption of RSK3 binding to mAKAP in vivo via AAV expression of a competing

peptide attenuates pressure overload -induced cardiac hypertrophyRandi Parks - The impact of ovariectomy on cAMP/PKA -dependent mechanisms involved in cardiac

excitation -contraction couplingKonstantin Drosatas - Combined cardiac PPARα and PPARγ activation reduce PGC -1α gene expression

and compromise binding of PPARγ on PGC -1αGuansheng Liu - A Novel Human R25C -Phospholamban Mutant Is Associated with Superinhibition of

Calcium Cycling and Increased ApoptosisShigeki Miyamoto - Hexokinase -II regulates mitochondria specific autophagy in response to ischemiaPhilip Bidwell - Endogenous HAX -1 depresses the phospholamban inhibitory activitySara Menazza - Impaired Nitroso -Redox Signaling is Involved in Human Heart FailurePatrick McLendon - Inhibition of tubulin deacetylation is protective in cardiac proteinopathy through

autophagy -mediated aggregate reductionShathiyah Kulandavelu - Cardio -protection following myocardial infarction in female is absent in mice

lacking the S -nitrosoglutathione reductase (GSNOR)

10:45AM – 11:45 AM ECI - Alternative Science Careers Paths Chair: Mark Kohr and Sakthivel SadayappanLisa Schwartz -Longacre, Program Officer, NHLBI/NIHStephanie Finnegan, President of Biopharma, BioRASIWayne Bowden, Lead Program Manager, BioRASIMitchell Fuerst, Managing Partner, Fuerst, Ittleman, David & Joseph, P.L.Grant Budas, Scientist, Gilead Sciences

1:00 - 2:30 PM - Interest Group 1 Session - Signaling from hypertrophy to failure: Apoptosis, Necrosis and Fibrosis

Chair: Roberta Gottlieb and Gao ChenMaria Kontaridis - Cardiomyocyte -specific expression of RhoA protects against pressure -overload

induced heart failure but facilitates cardiac fibrosis John Elrod – Synaptolysis - A novel mechanism of programmed necrosisYibin Wang - Mitochondrial Superoxide Production in Healthy and Diseased HeartSarah Franklin -Targeted remodeling of cardiac histone modifications to regulate hypertrophy and

failure

1:00 – 2:30 PM – Interest Group 6 Session - Ion channels and Arrhythmias Chair: Susan Howlett and Seth RobiaShey -Shing Sheu – Characteristics and functions of mitochondrial Ca2+ transport mechanisms in cardiac

muscle cells Sam Dudley - NaV1.5 function in the heartBrian O’Rourke – ROMK function in the heartW. Jonathan Lederer - Ryanodine receptor function in cardiac stress

2:30 – 3:30 Coffee Break

3:30 – 4:30 PM Interest Group 3 Session - Stem Cell & Gene Therapy Chair: Joseph Rabinowitz and Wen DingRoger Hajjar - Gene Therapy in Patients With Severe Heart Failure Hee Cheol Cho - Gene therapy for generation of a cardiac pacemakerWillem J. de Lange - Engineered cardiac tissue (ECT) derived from hiPSC cardiomyocytes Loren Field - Genetic control of cardiomyocyte renewal

3:30 – 4:30 PM Interest Group 7 Session - Ischemia, Cardioprotection & MitochondriaChair: Charles Steenbergen and Chris MurrayBruce Ito - Cardiac Autophagy and Clinical Implications in Metabolic SyndromeHemal Patel - Caveolins in cardiac protection: from membrane to mitochondriaRobert Kloner - Hypothermia for reducing myocardial infarct size and the no reflow phenomenonStacey House - Fibroblast Growth Factor Receptors in Endothelium and Cardiomyocytes in Acute

Myocardial Infarction and Post -Ischemic Cardiac Remodeling

4:30 – 5:30 PM Young Investigator Competition (Junior)Chair: Jeffrey RobbinsNirmala Hariharan - Nucleostemin antagonizes senescence of cardiac progenitor cells - Mentor: Mark

SussmanMaggie Lam - Protein kinetic signatures of the remodeling heart following isoproterenol stimulation -

Mentor: Peipei PingCatherine Makarewich - Transient receptor potential channels contribute to pathological structural and

functional remodeling after myocardial infarction - Steve HouserSarah Schumacher -Bass - Paroxetine -mediated GRK2 inhibition reverses cardiac dysfunction and

remodeling post -myocardial infarction -Wally Koch

5:30 – 6:30 PM Young Investigator Competition (Senior)Chair: Howard RockmanPaul Burridge - Human induced pluripotent stem cells predict breast cancer patient’s predilection to

doxorubicin -induced cardiotoxicity - Mentor: Joseph WuChad Grueter - MED13 dependent signaling from the heart enhances metabolism in adipose tissue and

liver and confers leanness - Mentor: Eric OlsonMark Kohr - Glyceraldehyde -3 -phosphate dehydrogenase acts as a mitochondrial trans -S -nitrosylase in

the heart - Mentor: Charles SteenbergenStephen Lange - Defining the role of the stress sensors MLP and CARP in signaling pathways that lead to

dilated cardiomyopathy - Mentor: Ju Chen

Annual Young Investigator Awards (YIAs) were established by the North American Section of the ISHR to recognize outstanding research in the field of cardiovascular science by junior investigators. From applications received for this meeting, finalists in each of the two categories, Graduate Students and Early Postdoctoral Fellows (within 4 years of completing their degree) and Senior Postdocs and Early Assistant Professors (between 4 and 10 years after completing their degree), were selected by a Committee to present their work at our meeting. A panel of judges will make the final award (presented at the banquet) based on the scientific merit of a submitted unpublished manuscript, quality of the oral presentation, and responses to questions asked during the discussion period. The finalists, their presentation titles and their mentors are listed above.

Sponsored by Envision Conference Planners, Roz Robbins, Sole Proprietor.

6:30 - 8:00 PM Reception

Tuesday May 13, 2014

Overview7:00AM 5:00PM Registration Grande Promenade Foyer7:00 AM 6:00 PM Speaker Ready Room Regency Conference Room7:00 AM 8:00 AM Continental Breakfast Starlight Ballroom8:00 AM 8:45 AM Plenary Talk Grande Promenade9:00 AM 10:30 AM Interest Group 2 Grande Promenade9:00 AM 10:30 AM Interest Group 5 Regency Ballroom10:30 AM 11:00 AM Coffee Break Grande Promenade11:00 AM 12:30 PM Interest Group 2 Grande Promenade11:00 AM 12:30 PM Session I Regency Ballroom12:30 PM 1:15 PM Lunch Grande Promenade12:30 PM 1:15 PM NAS Council Meeting Miramar North1:15 PM 2:00 PM Posters Spanish Suite2:00 PM 3:30 PM Session II Grande Promenade2:00 PM 3:30 PM Session III Regency Ballroom3:30 PM 4:30 PM Posters and Coffee Break Spanish Suite4:30 PM 6:00 PM Session IV Grande Promenade4:30 PM 6:00 PM Session V Regency Ballroom6:15 PM 7:00 PM Peter Harris Research Achievement Award Grande Promenade7:00PM 10:00 PM ECI Social Sea Breeze Bar (by the pool)7:00PM 8:30PM International Council Retreat Miramar South

8:00 AM – 8:45 AM Plenary TalkChair: Joshua HareAndrew Schally - Nobel Prize in Medicine 1977 Distinguished Medical Research Scientist of the Department of Veterans AffairsHead of the Endocrine, Polypeptide and Cancer InstituteVeterans Affairs Medical Center, Research Service (151) Miami, FL and South Florida VA Foundation for Research and EducationDistinguished Leonard Miller Professor of PathologyProfessor Division of Hematology/Oncologyand Division of Endocrinology Department of MedicineMiller School of Medicine, University of Miami, FL

Talk title: Hypothalamic Hormones: From Neuroendocrinology to Therapy of Cancer and Other Diseases

9:00 AM – 10:30 AM – Interest Group 2 Session - Cardiac Metabolism: “The active role of myocardial lipid storage”

Chair: Rong Tian and Jessica ToliJason Dyck - How does ATGL regulates cardiac fatty acid oxidation?Doug Lewandowski - TAG turnover and pathological hypertrophySteve Kolwicz - Does the TAG metabolism affect the response to ischemia?Peter Crawford - Myocardial ketone body oxidation attenuates pressure overload -induced ventricular

dilatation and reactive oxygen species accumulation

9:00 AM - 10:30 AM – Interest Group 5 Session - Excitation -Contraction Coupling: "Novel Mechanisms In Calcium Microdomain Signaling”

Chair: Evangelia (Litsa) Kranias and Randi ParksXander Wehrens - Sarcoplasmic Reticulum Calcium Leak and Re -entry Bjorn Knollmann - Calcium and myofilaments – an update on arrhythmia mechanisms in hypertrophic

cardiomyopathyPeter J Mohler - Ankyrin - and spectrin -based pathways for human arrhythmiaJulie Bossuyt - Protein kinase D: a regulator of Calcium signaling?

10:30 AM - 11:00 AM – Coffee Break

11:00 AM – 12:30 PM – Interest Group 4 Session - Contractile & Regulatory ProteinsChair: Michael Regnier and Sumit KarJohn Konhilas - LKB1 as a novel regulator of contractilityRenzhi Han - Molecular mechanism to repair the sarcolemmal injuryBrandon Biesiadecki - Troponin phosphorylation: Isolated or integrated events?Margaret Westfall - Direct and adaptive modulation of contractile performanceMd. Shenuarin Bhuiyan - Physiological significance of cMyBPC's interaction with actin and myosin in vivo

11:00AM - 12:30 PM – Session I: Stem Cells I Chair: Jianyi Zhang and Ivonne SchulmanMark Sussman - Cardiac Regeneration: Uncommon Sense for Common ProblemsAnnarosa Leri - The aging cardiomyopathy: pathophysiology and therapeutic strategiesLior Gepstein - Induced pluripotent stem cells for disease modeling and drug discoveryJoseph Wu - iPSCs for Modeling Human Heart Disease

12:30 PM – 1:15 PM Lunch

1:15 PM – 2:00 PM Posters

2:00 PM - 3:30 PM - Session II: Novel Signaling Pathways that Induce Pathological Hypertrophy Chair: Ju Chen and Khadija Rafiq Walter Koch - Novel Role for GRK5 in Cardiac Hypertrophy Thomas Force - Targeting TNNI3K in a variety of pathologic scenariosElizabeth Mcnally - Genetic Modifiers of CardiomyopathySathyamangla Naga Prasad - Inhibition of β -adrenergic receptor resensitization underlies cardiac

dysfunction and failure

2:00 PM - 3:30 PM Session III: Calcium Signaling Pathways in the Failing Heart IChair: David Eisner and Margaux HornJoan Heller Brown - Mitochondrial reprogramming by CaMKIIδ contributes to the cardiomyopathy of

pressure overload in miceMark Anderson - CaMKII in heart failureSusan Steinberg - The structural determinants of protein kinase C -delta activity; Rules of

phosphorylationChristian Faul - FGF23 -mediated Activation of FGFR4 is a Novel Hypertrophic Signaling Pathway FGF23 -

mediated Activation of FGFR4 is a Novel Hypertrophic Signaling Pathway

3:30 PM - 4:30 PM – Posters and Refreshments

4:30 PM - 6:00 PM Session IV: Mechanisms of Myocyte Death – AutophagyChair: Chris Baines and Maggie LamJunichi Sadoshima - The role of Drp1 in mitochondrial quality control in the heart.Peipei Ping - The Design, Characterization, and Function of Mitochondrial ProteomesGerald Dorn - Mitochondrial dynamism orchestrates mitochondrial biogenesis and mitophagy in the

heartRichard Kitsis – Towards development of a small molecule drug to reduce heart damage from

myocardial infarction

4:30PM - 6:00 PM Session V: Calcium Signaling Pathways in the Failing Heart IIChair: Lorrie Kirshenbaum Steven Houser - Do TRPC Channels Contribute to Disturbed Contractility in Heart Failure?Donald Bers - SR Ca leak: Molecular basis and role in arrhythmiasLuis Fernando Santana - Local control of SR dyads during the development of heart failureFederica del Monte - Presenilin: a novel EC -coupling protein to target calcium dishomeostasis

6:15 – 7:00 PM Plenary SessionChair: Matt Hori and Elizabeth MurphyPeter Harris Research Achievement Award:Evangelia Kranias, PhDHanna Professor and Director Cardiovascular BiologyDistinguished University ProfessorCo -Director, Cardiovascular Center of ExcellenceDepartment of Pharmacology & Cell BiophysicsUniversity of Cincinnati College of Medicine

Talk Title: Calcium Circuits in the Heart: A Matter of Life or Death

7:00 - 10:00 PM ECI Social

Wednesday – May 14, 2014

Overview

7:00AM 5:00PM Registration Grande Promenade Foyer7:00 AM 6:00 PM Speaker Ready Room Regency Conference Room7:00 AM 8:00 AM Continental Breakfast/ Starlight Ballroom7:00 AM 8:00 AM International Council Meeting Miramar North8:00 AM 8:45 AM Plenary Talk Grande Promenade9:00 AM 10:30 AM Session VI Grande Promenade9:00 AM 10:30 AM Session VII Regency Ballroom10:30 AM 11:00 AM Coffee Break Grande Promenade11:00 AM 12:30 PM Session VIII Grande Promenade11:00 AM 12:30 PM Session IX Regency Ballroom12:30 PM 1:15 PM Lunch Starlight Ballroom12:30 PM 1:30 PM International Council meeting Miramar North1:15 PM 2:00 PM Posters Spanish Suite2:00 PM 3:30 PM Session X Grande Promenade2:00 PM 3:30 PM Session XI Regency Ballroom3:30 PM 4:30 PM Posters and Coffee Break Spanish Suite4:30 PM 6:00 PM Session XII Grande Promenade4:30 PM 6:00 PM Session XIII Regency Ballroom6:00 PM 6:45PM Oustanding Investigator Award Grande Promenade6:45PM 9:00PM Banquet Starlight Ballroom

8:00 AM – 8:45 AM Plenary TalkChair: Joshua HarePascal GoldschmidtSenior Vice President for Medical Affairs and DeanUniversity of Miami Miller School of MedicineChief Executive Officer, University of Miami Health System

Talk Title: Of Aging, Inflammation, Frailty, and Stem Cells

9:00 AM – 10:30 AM Session VI: Stem Cells in Clinical TrialsChair: Alan Heldman and Grant BudasRoberto Bolli - Cell therapies for the treatment of heart failureAtul Chugh - Stem Cell Therapy for Heart Failure: Lessons Learned from Cardiac ImagingJoshua Hare – Mesenchymal Stem Cells and the Prevention of Heart FailureVasileios Karantalis - Genetic Modification of ckit+ Cardiac Stem Cells to Overexpress Pim1 Enhances

their Cardioreparative Ability After Intramyocardial Delivery

9:00 AM – 10:30 AM Session VII: Regulation of Myocyte Gene ExpressionChair: Eva Van Rooij and Samarjit DasJoseph Hill - Unfolded Protein Response and CardioprotectionNanette Bishopric - Tackling maladaptive transcription programs in hypertrophy to prevent heart failure Lena Shehadah - Osteopontin RNA Aptamer Protects Against Cardiac DysfunctionCoralie Poizat - CaMKII epigenetic control of histone H3 in heart failure

10:30 AM – 11:00 AM – Coffee Break

11:00 AM - 12:30 PM Session VIII: Stem Cells IIChair: Omaida Velazquez and Victorea Florea Chunming Dong - microRNA Regulation of Endothelial Progenitor Cell Senesce, Vascular Repair and

AngiogenesisClaudia Rodrigues - Molecular Mechanisms that Control Stem Cell Self -Renewal and Survival under

Ischemic StressPiero Anversa - Human Cardiac Stem Cell ClassesSunjay Kaushal – How Aging and Physiological state of the Pediatric Heart Effects the Functional Activity

of Cardiac Stem Cells.

11:00 AM - 12:30 PM Session IX: MitochondriaChair: Matt Hori and Monte WillisElizabeth Murphy - Role of Mitochondria in Ischemia -Reperfusion InjuryWang Wang - Mitochondrial Superoxide Production in Healthy and Diseased HeartMadesh Muniswamy - A rheostat for mitochondrial Ca2+ flux in cardiovascular systemXuejun Wang - Loss of Function of an Extraproteasomal Ubiquitin Receptor Ubiquilin1 in Cardiomyocytes

Exacerbates Cardiac Proteotoxicity 12:30 PM – 1:15 PM Lunch

1:15 PM - 2:00 PM Posters

2:00 PM – 3:30 PM Session X: Novel Therapeutics For Heart FailureChair: Metin Avkiran and Mark KohrJonathan Stamler - New S -Nitrosylation Signals In The HeartAnthony Rosenzweig - Mining Exercise For New Therapeutic TargetsMichael Kapiloff - Targeting mAKAP Signaling Complexes In Heart FailureTimothy Mckinsey - Regulation Of Cardiac Hypertrophy And Fibrosis By Lysine Acetylation

2:00 PM - 3:30 PM Session XI: MetabolismChair: Lawrence Young and Maengjo KimGary Lopaschuk - Inhibiting fatty acid oxidation as a novel approach to treating heart failureJenny Van Eyk - Cross talk between phosphorylation and oxidative post -translational modifications

regulate mitochondrial and cell functionHeinrich Taegtmeyer - Metabolic Signals as Regulators of Myocardial Protein TurnoverMichael Regnier - AAV6 -mediated overexpression of Ribonucleotide Reductase (R1R2) that increases

myocardial dATP and improves function of normal and failing hearts.

3:30 PM - 4:30 PM Posters and Refreshments

4:30 PM - 6:00 PM Session XII: Heart Failure Insights from Developmental BiologyChair: Sakthivel Sadayappan and Sarah FranklinHoward Rockman - Biased GPCR Ligands for Heart FailureLeslie Leinwand - Myosin Myopathies: Pathogenesis and Development of TherapiesJoy Lincoln - Embryonic Origins of Calcific Aortic Heart Valve DiseaseCarmen Sucharov - FXR1G/E and regulation of microRNA function in cardiac disease and differentiation

4:30 PM – 6:00 PM Session XIII: Novel Regenerative TherapiesChair: Sudhiranjan GuptaKunhua Song - Induction of fibroblasts into cardiac -like myocytesKevin Costa – Tissue Engineering Strategies for Cardiac TherapyLuiza Lima Bagno - Reduction of Scar Tissue after GHRH -A Treatment in a Swine Model of Sub -acute

Ischemic Cardiomyopathy.Viky Suncion - Effect Of Transendocardial Autologous Cardiac Stem Cells And Bone Marrow

Mesenchymal Stem Cells To Reduce Infarct Size And Restore Cardiac Function In a Heart Failure Swine Model

6:00PM – 6:45 PMChair: Richard Moss and David EisnerOutstanding Investigator Award:Åsa B. Gustafsson Ph.D.Associate ProfessorSkaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego

Talk Title: Role of Mitochondrial Autophagy in Cardioprotection

6:45 PM – 9:45 PM Banquet

Thursday May 15, 2014

Overview

7:00AM 12:00PM Registration Grande Promenade Foyer7:00 AM 12:00 PM Speaker Ready Room Regency Conference Room7:00 AM 8:00 AM Continental Breakfast Starlight Ballroom8:00 AM 8:45 AM President’s Lecture Grande Promenade9:00 AM 10:30 AM Session XIV Grande Promenade9:00 AM 10:30 AM Session XV Regency Ballroom10:30 AM 11:00 AM Coffee Break Grande Promenade11:00 AM 12:30 PM Session XIV Grande Promenade11:00 AM 12:30 PM Session XV Regency Ballroom

8:00 AM - 8:45AM President’s LectureChair: Metin AvkiranKeiichi Fukuda, MD, PhDPresident, ISHR Japanese SectionProfessor, Department of Regenerative Medicine and Advanced Cardiac Therapeutics Keio University School of Medicine

Talk Title: Regenerative Medicine of the Heart using iPS cells

9:00 AM – 10:30 AM Session XIV: Mechanisms of Familial CardiomyopathiesChair: Richard Moss and Stephen LangeJohn Solaro - Mechanisms and Potential Therapies in Familial Cardiomyopathies.Danuta Szczesna -Cordary - Novel strategies to combat Familial Cardiomyopathy associated with the

Myosin Regulatory Light ChainJeffrey Robbins - cardiac myosin binding protein C; insights from structure -function studiesSakthivel Sadayappan - Increased Inflammation and Oxidative Stress in a Mouse Model of Dilated

Cardiomyopathy

9:00 AM - 10:30 AM Session XV: Cardiac FibrosisChair: Pieter de Tombe and Rushita BagchiBurns Blaxall - Targeting pathologic activation of cardiac fibroblasts in myocardial fibrosisNikolaos Frangogiannis - TGF -beta signaling in cardiac fibrosisJeffrey Molkentin - Understanding the origins and activity of the cardiac fibroblastSumanth Prabhu - New insights on inflammation and heart failure

10:30 AM – 11:00 AM Coffee Break

11:00 AM - 12:30 PM Session XVI: Stem Cells IIIChair: Joshua Hare and Nirmala HariharanDaniel Bernstein - Maturation of Cell Signaling in hiPSC -CMs: Regulators of Function and StructureKeith March – Stem Cell Therapies for Human Cardiovascular DiseaseMonte Willis - Non -targeted metabolomics analysis of Muscle Ring Finger -1 (MuRF1), MuRF2, and

MuRF3 in vivo reveals novel and redundant metabolic changes

11:00 AM – 12:30 PM Session XVII: Compartmentation in Cardiac Signal Transduction - Chair: Kimberly Dodge -Kafka and Catherine PassarielloViacheslav Nikolaev - Remodeling of cAMP microdomains in hypertrophy and heart failure Carmen Dessauer - Facilitation of cAMP Signaling in Heart by Anchored Adenylyl Cyclase ComplexesTimothy O’Connell - Intranuclear alpha -1 adrenergic receptor signaling and physiologic function in

cardiac myocytes

12:30 PM Meeting Closed

Poster Sessions

Posters are located in the Spanish Suite.

Poster Session 1: P1 -01 to P1 -52 - Tuesday, May 13 1:15 -2:00 PM and 3:30 -4:30 PM

Poster Session 2: P2 -01 to P2 -52 - Wednesday, May 14 1:15 -2:00 PM and 3:30 -4:30 PM

Presenting author underlined

Poster Session 1: P1 -01 to P1 -52 - Tuesday, May 13 1:15 -2:00 PM and 3:30 -4:30 PM

Heart Failure/Hypertrophy Part I

P1 -01 Lysyl oxidase inhibition can reverse age -related myocardial fibrosis.Nicole Rosin1, Timothy Lee1, Jean -Francois Legare1, 1Dalhousie University, Halifax, NS, Canada

P1 -02 A novel PKCalpha splicing isoform in signaling for cardiac hypertrophyCHEN GAO1, Jianli Gong2, William Wang2, Susan Steinberg2, Yibin Wang1, 1Molecular Biology Institute,University of California, Los Angeles, Los Angeles,CA, USA, 2Department of Pharmacology, Columbia University, New York, USA

P1 -03 Paroxetine -mediated GRK2 inhibition reverses cardiac dysfunction and remodeling post -myocardial infarctionSarah Schumacher1, Erhe Gao1, John Tesmer2, Walter Koch1, 1Temple University School of Medicine, Philadelphia, PA, USA, 2University of Michigan, Ann Arbor, MI, USA

P1 -04 A novel human mutation in Hsp20 (S10F) abrogates the contractile and protective effects of this protein in the heartGuansheng Liu1, Wen Zhao1, Elizabeth Vafiadaki2, Chi Keung Lam1, Min Jiang3, Jack Rubinstein3, George Adly1, Evangelia G. Kranias1,2, 1Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Molecular Biology Division, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, 3Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA

P1 -05 A novel human R25C -phospholamban mutant is associated with superinhibition of calcium cycling and increased apoptosisGuansheng Liu1, Ana Morales2,4, Elizabeth Vafiadaki5, Kobra Haghighi1, Ray E. Hershberger2,4, George Adly1, Evangelia G. Kranias1,5, 1Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Division of Human Genetics, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA, 3Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA, 4Dorothy M. Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus, OH, USA, 5Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece

P1 -06 Impaired nitroso -redox signaling is involved in human heart failureSara Menazza1, Angel Aponte2, Charles Steenbergen3, Elizabeth Murphy1, 1System Biology Center, NHLBI, NIH, Bethesda, MD, USA, 2Proteomics Core Facility, NHLBI, NIH, Bethesda, MD, USA, 3Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA

P1 -07 Inhibition of tubulin deacetylation is protective in cardiac proteinopathy through autophagy -mediated aggregate reductionPatrick M. McLendon1, Bradley S. Ferguson2, Hanna Osinska1, Md. Shenuarin Bhuiyan1, Jeanne James1, Timothy A. McKinsey2, Jeffrey Robbins1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, 2University of Colorado, Denver, Aurora, CO, USA

P1 -08 Cardio -protection following myocardial infarction in female is absent in mice lacking the S -nitrosoglutathione reductase (GSNOR).Shathiyah Kulandavelu1, Ellena Paulino1, Lauro Takeuchi1, Wayne Balkan1, Joshua M Hare1, 1Stem Cell Institute, Miami, Florida, USA

P1 -09 miRNA Expression in hypoplastic left heart syndromeJuliana Sucharov2, Anis Karimpour -Fard1, Karin Nunley1, Brian Stauffer1,3, Shelley Miyamoto2,1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 2Children's Hospital Colorado, Aurora, CO, USA, 3Denver Health and Hospital Authority, Denver, CO, USA

P1 -10 Gene expression profiling in pediatric and adult heart failureShelley Miyamoto2,1, Matthew Taylor1, Anis Karimpour -Fard1, Kenneth Jones1, Brian Stauffer1,3, Carmen Sucharov1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 2Children's Hospital Colorado, Aurora, CO, USA, 3Denver Health and Medical Authorities, Denver, Co, USA

P1 -11 Hypoxia sensitivity in DMD: a potential link between respiratory insufficiency and heart failureZachary Stelter1, Jana Strakova1, DeWayne Townsend1, 1University of Minnesota, Minneapolis, MN, USA

P1 -12 Υ2 -AMPK regulates pathological cardiac hypertrophy in miceMaengjo Kim1, Lorena Menendez1, Richard Palmiter1, Rong Tian1, 1University of Washington, Seattle, WA, USA

P1 -13 Disruption of RSK3 binding to muscle A -kinase anchoring protein in vivo via adeno -associated virus expression of a competing peptide attenuates pressure overload -induced cardiac hypertrophyCatherine Laura Passariello1, Michael D Kritzer1, Hrishikesh Thakur1, Michael Sanders1, Jinliang Li1, Michael S. Kapiloff1, 1University of Miami, Miami, FL, USA

P1 -14 Genome wide study of TFIIB binding and its role in cardiac hypertrophyDanish Sayed1, Zhi Yang1, Maha Abdellatif1, 1Rutgers New Jersey Medical School, Newark, NJ, USA

P1 -15 Frailty predicts cardiac dysfunction independently of age in older miceSusan Howlett1, 1Dalhousie University, Halifax, Nova Scotia, Canada

P1 -16 Down -regulation of adenine nucleotide translocator 1 exacerbates cardiac inflammationShi Pan1, Nadan Wang1, Sara Bisetto1, Shey -Shing Sheu1, 1Thomas Jefferson University, Philadelphia, USA

P1 -17 Cardiac extracellular matrix remodelling following recovery from pacing -induced heart failure in the sheepMargaux Horn1, Katharine Dibb1, Andrew Trafford1, 1University of Manchester, Manchester, UK

P1 -18 Restoration of transverse (t) tubules following recovery from heart failure (HF)Jessica Caldwell1, David Eisner1, Katharine Dibb1, Andrew Trafford1, 1University of Manchester, Manchester, UK

Cardiac Regeneration/Cell Therapies

P1 -19 Cytoprotective effect of growth hormone releasing hormone agonist in cardiac stem cellsVictoria Florea1, 1Interdisciplinary Stem Cell Institute, University of Miami, Miami, FL, USA, 2Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA, 3Department of Pathology, University of Miami, Miami, FL, USA, 4Division of Cardiology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami,FL, USA, 5Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, Miami, FL, USA

P1 -20 Targeting gene expression to endothelial cells of specific organsAnahita Mojiri1, Nadia Jahroudi1, 1University of Alberta, Edmonton/Alberrta, Canada

P1 -21 Genetic ablation of S -nitrosoglutathione reductase (GSNOR) in mice enhances proliferative expansion of adult heart progenitors and myocytes post myocardial infarctionKonstantinos Hatzistergos1, Ellena Paulino1, Raul Dulce1, Lauro Takeuchi1, Shathiyah Kulandavelu1, Wayne Balkan1, Rosemeire Kanashiro -Takeuchi1, Joshua Hare1, 1University of Miami, Interdisciplinary Stem Cell Institute, Miami, Fl, USA

P1 -22 Connexin 43 overexpression enhances cardioprotective effects of cortical -bone derived stem cells in the infarcted heartDanielle Trappanese1, Jason Duran1, Thomas Sharp1, Timothy Starosta1, Yumi Chiba1, Remus Berretta1, Sharven Taghavi1, John Gaughan2, Joseph Rabinowitz2, Hajime Kubo1, Steven Houser1, 1Temple University School of Medicine, Cardiovascular Research Center, Philadelphia, PA, USA, 2Temple University School of Medicine, Center for Translational Medicine, Philadelphia, PA, USA

P1 -23 Isolation and characterization of cortical bone stem cells from Göttingen minipigThomas Sharp1, Sadia Mohsin1, Timothy Starosta1, Remus Berretta1, Jason Duran1, Hajime Kubo1, Steven Houser1, 1Temple University School of Medicine, Philadelphia, PA, USA

P1 -24 Effects of Connexin 43 presence or absence in human bone -marrow derived mesenchymal stem cellsCristina Sanina1, Ivonne Schulman1, Michael Bellio1, Wayne Balkan1, Claudia Rodrigues1, Joshua Hare0, 1University of Miami, Miami, FL, USA

Contractility & Mechanics

P1 -25 Physiological significance of cMyBPC's interaction with actin and myosin in vivoMd. Shenuarin Bhuiyan1, Jeanne James1, Hanna Osinska1, James Gulick1, Jeffrey Robbins1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

P1 -26 Myofilament length dependent activation: role of titinYounss Ait -Mou1, Karen Hsu3, Marion Greaser2, Tom Irving3,1, Pieter de Tombe1, 1Loyola University Chicago, Maywood IL, USA, 2University of Wisconsin -Madison, Madison WI, USA, 3Illinois Institute of Technology, Chicago UL, USA

P1 -27 Micro -RNA765 targets Protein Phosphatase Inhibitor -1 and suppresses contractilityWen -Feng Cai1, Stela Florea1, Jiang Qian1, Wen Zhao1, Tracy Pritchard1, Chi Keung Lam1, Guansheng Liu1, Kobra Haghighi1, Djamel Lebeche2, Long Jason Lu3, Jingyuan Deng3, Guo -Chang Fan1, Roger J. Hajjar2, Evangelia G. Kranias1, 1Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA, 3Division of Biomedical Informatics, Cincinnati Children's hospital research Foundation, Cincinnati, OH, USA

P1 -28 Increased inflammation and oxidative stress exacerbates contractile dysfunction in dilated cardiomyopathyThomas Lynch1, Mayandi Sivaguru2, Murugesan Velayutham3, Arturo Cardounel3, Christoph Liebetrau4, David Barefield1, Suresh Govindan1, Christian Troidl5, Sakthivel Sadayappan1, 1Loyola University Chicago, Maywood, IL, USA, 2University of Illinois at Urbana -Champaign, Urbana -Champaign, IL, USA, 3The Ohio State University, Columbus, OH, USA, 4Kerckhoff Heart and Thorax Center, Bad Nauheim, Hessen, Germany, 5Kerckhoff Institute for Heart Research, Justus -Liebig -University Giessen, Giessen, Hessen, Germany

P1 -29 Impact of anesthesia and storage on post -translational modifications of myofilament proteins in mouse ventricular lysatesMegan S. Utter1, Chad M. Warren1, R. John Solaro1, 1Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, USA

P1 -30 Cross -bridge cycling rates are length independent: Implications for cardiac economy and the Frank -Starling LawDaria Amiad -Pavlov1, Amir Landesberg1, 1Technion -IIT, Haifa, Israel

P1 -31 Dilated cardiomyopathy linked mutation cTnT R173W in cardiomyocyte -derived human induced pluripotent stem cells affects sarcomere structure and functionKathleen Broughton1, Ying -Hsi Lin1, Veronica Sanchez -Freire2, Beata Wolska1, Joseph Wu2, John Solaro1, Brenda Russell1, 1University of Illinois at Chicago, Chicago, IL, USA, 2Stanford University, Chicago, IL, USA

P1 -32 Discovery of enzyme modulators via high -throughput time -resolved FRET in living cellsSimon Gruber1, Razvan Cornea1, Kurt Peterson2, Gregory Gillispie1,2, Seth Robia3, David Thomas1, 1University of Minnesota, Minneapolis, MN, USA, 2Fluorescence Innovations, Inc., Minneapolis, MN, USA, 3Loyola University, Chicago, IL, USA

P1 -33 Functional effects of E143K mutation in myosin Essential Light Chain associated with Restrictive Cardiomyopathy in humansChen -Ching Yuan1, Wenrui Huang1, Katarzyna Kazmierczak1, Jingsheng Liang1, Ana I Rojas1, Rosemeire Kanashiro -Takeuchi1, Joshua Hare1, Danuta Szczesna -Cordary1, 1University of Miami, Miami, USA

Mitochondria

P1 -34 The mitochondrial protein FASTKD1 protects cells from oxidative stress induced death independently of the mitochondrial permeability transition poreKurt Marshall1, Christopher Baines1, 1University of Missouri - Columbia, Columbia, Missouri, USA

P1 -35 Genetic manipulation of cardiac mitochondrial phosphate carrier does not affect permeability transitionManuel Gutierrez -Aguilar1, Diana Douglas1, Anne Gibson1, Timothy Domeier1, Jeffery Molkentin2, Christopher Baines1, 1University of Missouri - Columbia, Columbia, MO, USA, 2University of Cincinnati, Cincinnati, OH, USA

P1 -36 GAPDH targets specific mitochondrial proteins as a trans -S -nitrosylaseMark Kohr1,2, Elizabeth Murphy2, Charles Steenbergen1, 1Johns Hopkins University School of Medicine, Baltimore, MD, USA, 2National Heart, Lung and Blood Institute/National Institutes of Health, Bethesda, MD, USA

P1 -37 Recovery of mitochondrial bioenergetics after hypoxia via regulating pyruvate dehydrogenase kinase and AMP -activated kinaseJessica Toli1, Minzhen He1, Carolyn Suzuki1, Maha Abdellatif1, 1Rutgers University, Newark, NJ

P1 -38 Effect of chronic continuous hypoxia on mitochondrial enzymes in hearts of spontaneously hypertensive rats (SHR) and in conplastic strain SHR -mtBN

Anna Chytilova1, Martin Kalous2, Romana Weissova2, Zdenek Drahota1, Iveta Brabcova2, Jitka Zurmanova2, Olga Nováková2, Michal Pravenec1, Frantisek Kolar1, Jan Neckar1, 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2Faculty of Science, Charles University in Prague, Prague, Czech Republic

P1 -39 ROCK2 promotes mitochondrial dysfunction in the diabetic heartGuorong Lin1, Kathleen M. MacLeod1, 1Faculty of Pharmaceutical Sciences, University of British Columbia, Vanvouver, Canada

P1 -40 miR -181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivoSamarjit Das1, Qin Shao1, Djahida Bedja1,2, Nathaniel Campbell1, Brittany Dunkerly1,3, Venugopal Chenna4, Anirban Maitra4,1, Charles Steenbergen1, 1Johns Hopkins University, Baltimore MD, USA, 2Australian School of Advanced Medicine, Macquarie University, Sydney, Australia, 3Notre Dame of Maryland University, Baltimore MD, USA, 4MD Anderson Cancer Center, Houston, TX, USA

P1 -41 Inhibition of soluble epoxide hydrolase improves cardiac function and limits mitochondrial damage from ischemic injuryMaria Akhnokh1, Victor Samokhvalov1, Feng Hua Yang1, Xiuhua Wang3, Ratnadeep Basu3, Gavin Y. Oudit4,5, Zamaneh Kassiri3,5, Woo jung Cho5, Bruce Hammock6, John M. Seubert1,2, 1Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada, 2Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada, 3Department of Physiology, University of Alberta, Edmonton, Alberta, Canada, 4Division of Cardiology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, 5Mazankowski Alberta Heart Institute, Faculty of Medicine, University of Alberta., Edmonton, Alberta, Canada, 6Department of Entomology and Cancer Research Center, University of California., Davis, California, USA

P1 -42 Eicosanoids limit cardiac mitochondrial damage following starvation induced stressHaitham El -Sikhry1, Victor Samokhvalov1, Nasser Alsaleh1, John Falck2, John Seubert1,3, 1Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton,AB, Canada, 2Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA, 3Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada

Ischemia/Reperfusion Injury

P1 -43 A case of successful delayed thrombolysis in a patient with submassive pulmonary embolismRavinder Valadri1, 1Wright Center For Graduate Medical Education, Scranton, PA, USA, 2wilkes Barre General Hospital, Wilkes -Barre, PA, USA

P1 -44 Stimulation of the DR region of Na+ -K+ -ATPase -induced cardioprotection is mediated by activation of PP2AFei Hua1, Jin Zheng1, Jinsong Bian1, 1National University of Singapore, Singapore, Singapore

P1 -45 Cardioprotection with a Mas receptor inverse -agonist: A preclinical study in a swine model of myocardial infarctionBruce R. Ito1, John W. Adams2, Robert M. Mentzer, Jr.1,3, 1San Diego State University, San Diego, CA, USA, 2Arena Pharmaceuticals Inc., San Diego, CA, USA, 3Wayne State University, Detroit, MI,

USA

P1 -46 S -nitrosylation of TRIM72 at cysteine 144 protects against oxidation -induced degradation and reduces cell deathMark Kohr1,2, Alicia Evangelista1, Marcella Ferlito2, Charles Steenbergen2, Elizabeth Murphy1, 1National Heart, Lung and Blood/Institute, Bethesda, MD, USA, 2Johns Hopkins University School of Medicine, Baltimore, MD, USA

P1 -47 The prognostic significance of elevated troponins in patients with sepsis: a meta -analysisOlusegun Sheyin1, Oluwaseun Davies1, Wenlan Duan1, Xavier Perez1, 1Department of Medicine, Harlem Hospital Center, New York, NY, USA

P1 -48 Hypoxia -induced decrease in cardiac stem cell proliferation is associated with downregulation of Sirtuin 1Michael Bellio1, Claudia O Rodrigues1, Victoria Florea1, Wayne Balkan1, Joshua Hare1, Ivonne H Schulman1, 1University of Miami, Miami, Florida, USA

P1 -49 Cardiac Myosin Binding Protein -C is immunogenic following myocardial infarctionThomas Lynch1, Christoph Liebetrau2, Lukas Pyttel2, Christian Troidl2, Sakthivel Sadayappan1, 1Loyola University Chicago, Maywood, Illinois, USA, 2Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany

P1 -50 Cardiac ischemic tolerance in Goldblatt hypertension: effect of epoxyeicosatrienoic acid analogPetra Mandikova1, Martina Klevstigova1, Libor Kopkan2, Zuzana Huskova2, John Imig3, Ludek Cervenka2, Frantisek Kolar1, Jan Neckar1, 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2Institute of Clinical and Experimental Medicine, Prague, Czech Republic, 3Medical College of Wisconsin, Milwaukee, USA

P1 -51 MK5 deficiency affects scar maturation after myocardial infarctionSherin Nawaito1, Yanfen Shi1, Marc -Antoine Gillis1, Matthias Gaestel2, Jean -Claude Tardif1, Bruce Allen1, 1Université de Montréal, Montréal, Canada, 2Hannover Medical School, Hannover, Germany

P1 -52 Novel fusion of GLP -1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the ratWeike Bao1, Lucy Holt1, Rob Prince1, Gavin Jones1, Karpagam Aravindhan1, Mathew Szapacs1, April Barbour1, Larry Jolivette1, John Lepore1, Robert Willette1, Elena DeAngelis1, Beat Jucker1, 1GlaxoSmithKline, King of Prussia, PA, USA

Poster P2-03 will be presented in Poster Session 1, and will be located after poster P1-52

POSTER SESSION 2: Wednesday, May 14, 2014 1:15 -2:00p and 3:30 -4:30p

Heart Failure/Hypertrophy Part II

P2 -01 GRK5 exacerbates cardiac pathology through activation of the NFAT pathwayJonathan Hullmann1, Erhe Gao2, Kurt Chuprun2, Walter Koch2, 1Thomas Jefferson University, Philadelphia, PA, USA, 2Temple University School of Medicine, Philadelphia, PA, USA

P2 -02 Metabolomic analysis reveals a novel panel of blood -based biomarkers that distinguish between heart failure patients with reduced and preserved ejection fractionBeshay Zordoky1, Miranda Sung1, Justin Ezekowitz1, Rupasri Mandal1, Beomsoo Han1, Trent Bjorndahl1, Souhaila Bouatra1, Todd Anderson2, Gavin Oudit1, David Wishart1, Jason Dyck1, 1University of Alberta, Edmonton, Canada, 2University of Calgary, Calgary, Canada

*P2 -03 Reproducible ion -current -based approach for 24 -plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine modelsXiaomeng Shen1,2, Rebeccah Young1,3, Brian Page2,3, Nazeen Tata1, Jun Li1,2, Xiaotao Duan1,2, James A. Fallavollita3,4, John M. Canty1,4, Jun Qu1,2, 1University at Buffalo State University of New York, Buffalo, USA, 2Center for Excellence in Bioinformatics and Life Sciences, Buffalo, USA, 3Center for Research in Cardiovascular Medicine, Buffalo, USA, 4VA WNY Healthcare System, Buffalo, USA

**Poster P2-03 will be presented in Poster Session 1, and will be located after poster P1-52

P2 -04 The relationship between obesity and physical symptoms in patients with heart failureSeongkum Heo1, Debra Moser2, Sandra Dunbar3, Susan Pressler4, Terry Lennie2, 1University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA, 2University of Kentucky, Lexington, Kentucky, USA, 3Emory University, Atlanta, Georgia, USA, 4University of Michigan, Ann Arbor, Michigan, USA

P2 -05 Inhibition of autophagy suppresses transdifferentiation of cardiac fibroblasts into profibrotic myofibroblasts.Shivika Gupta1,2, Saeid Ghavami1, Krista Filameno1,2, Morvarid Kavosh1,2, Sunil Rattan1,2, Andrew Halayko1,3, Ian Dixon1,2, 1University of Manitoba, Winnipeg, Manitoba, Canada, 2Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada, 3Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada

P2 -06 Macrophage subsets: Contrasting roles in the development of myocardial fibrosisAlec Falkenham1, Devin Betsch1, Nicole Rosin1, Tim Lee1, Roberto de Antueno1, Roy Duncan1, Jean Francois Legare1, 1Dalhousie University, Halifax, Nova Scotia, Canada

P2 -07 CapZ beta1 subunitacetylation and actin assembly are regulated by HDAC in cardiomyocytesYing -Hsi Lin1, Chad M. Warren1, Brenda Russell1, 1University of Illinois at Chicago, Chicago, Illinois, USA

P2 -08 Physiological activation of Akt by PHLPP1 deletion protects against pathologicalAmy Taylor1, Gino Chesini1, Melissa Barlow1, Asa Gustafsson2, Joan Heller Brown1, Nicole Purcell1, 1Department of Pharmacology, University of California San Diego, La Jolla, CA, USA, 2Skaggs School of Pharmacy and Pharmaceutical Science, University of California, La Jolla, CA, USA

P2 -09 Newly discovered troponin I mutation (K206I) linked to hypertrophic cardiomyopathy impacts regulation of actomyosin ATPaseChad M. Warren1, Beata M. Wolska1,2, Tomoyoshi Kobayashi1, Grace M. Arteaga5, J. Martijn Bos4, Michael J. Ackerman3,4, R. John Solaro1, 1Departments of Physiology & Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago,Illinois, USA, 2Department of Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago,Illinois, USA, 3Departments of Medicine/Division of Cardiovascular Diseases, and Molecular Pharmacology & Experimental Therapeutics/Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA, 4Department of Pediatrics/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA, 5Departments of Pediatrics/ Division of Pediatric Critical Care, and Physiology, Mayo Clinic, Rochester, Minnesota, USA

P2 -10 Expression of mitochondrial calcium uniporter correlates with functional parameters in human heart failureChristian Silva -Platas1, Andrea Cordero -Reyes3, Guillermo Torre -Amione1,2, Gerardo García -Rivas1,2, 1Cátedra de Cardiología y Medicina Vascular. Escuela de Medicina. Tecnológico de Monterrey., Monterrey, Nuevo León, Mexico, 2Centro de Investigación Básica y Transferencia. Instituto de Cardiología y Medicina Vascular. Tec Salud., San Pedro Garza García, Nuevo León,

Mexico, 3Methodist DeBakey Heart & Vascular Center. The Methodist Hospital., Houston, TX, USA

P2 -11 Genetically mediated increase of T type Ca2+ current protects against cardiac dysfunction after myocardial infarctionHongyu Zhang1, Catherine Makarewich1, Hajime Kubo1, Foram Udesh1, Shavonn Smith1, Naser Jaleel1, Remus Berretta1, Jeffery Molkentin2, Erhe Gao1, Walter Koch1, Xiongwen Chen1, Jon George3, Steven Houser1, 1Temple University, Philadelphia, USA, 2University of Cincinnati, Cincinnati, USA, 3Debora Heart and Lung Center, New Jersey, USA

P2 -12 Genetic deletion of miR -208a causes cardiac autonomic imbalance and impaired calcium handlingRobert Davis1, Raghu Nagalingam1, Mariam Noor1, Da -Zhi Wang2, Beata Wolska1, John Solaro1, Madhu Gupta1, 1University of Illinois at Chicago, Chicago, IL, USA, 2Children's Hospital Boston -Harvard Medical School, Boston. MA, USA

P2 -13 The role of the RNA binding proteins HuR and AUF1 in β1 -adrenergic receptor mRNA stability in heart failureStephen Kraynik1, Andrew Gabanic1, Sarah Anthony1, Melissa Kelley1, Michael Tranter1, 1University of Cincinnati, Cincinnati, OH, USA

P2 -14 A novel angiotensin II type 1 receptor blocker (TRV120023), signaling through the β -arrestin pathway, improves cardiac function in a mouse model of dilated cardiomyopathyMadhusudhan Tarigopula1, Robert T. Davis 3rd1, David F. Wieczorek2, Jonathan D. Violin3, Beata M. Wolska1, R. John Solaro1, 1University of Illinois at Chicago, Chicago, IL, USA, 2University of Cincinnati Medical Center, Cincinnati, OH, USA, 3Trevena Inc., King Prussia, USA

P2 -15 Differences in GRK2 & GRK5 expression levels in adult versus pediatric patients suffering from Idiopathic Dilated CardiomyopathyElizabeth Medina1, Carman Sucharov1, Karen Dockstader1, Rebecca Sobus1, Shelley Miyamoto1, Brian Stauffer1, 1University of Colorado Health Sciences Center, Aurora, Co, USA

P2 -16 Ski modulates myofibroblast induced ECM remodeling through regulation of MMP -2 in rat cardiac fibroblastsMorvarid S. Kavosh1, Ian M.C. Dixon1, 1Institute of Cardiovascular Sciences, St. Boniface Research Center, University of Manitoba, Winnipeg,MB, Canada

P2 -17 Anthracycline cardiotoxicity: the pharmacokinetics and pharmacodynamics of dexrazoxane and its putatively cardioprotective metabolite ADR -925Anna Jirkovska -Vavrova1, Eduard Jirkovsky2, Jan Stariat1, Hana Jansova1, Jaroslav Roh1, Olga Lencova -Popelova2, Petra Kovarikova1, Martin Sterba2, Tomas Simunek1, 1Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic, 2Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic

P2 -18 Entering the matrix of heart failure: Alterations in myofilament -associated MMPs and TIMPs in naturally occurring canine dilated cardiomyopathyIlka Lorenzen -Schmidt1, Kristel Dimitrova1, W. Glen Pyle1, 1Cardiovascular Research Group, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada

Signalling Mechanisms

P2 -19 Candesartan and valsartan, contrary to irbesartan, are potent biased antagonists of adrenal (beta)arrestin -dependent, angiotensin II type 1 receptor -induced aldosterone production and improve cardiac function post -myocardial infarction

Anastasios Lymperopoulos1, Karlee Walklett1, Samalia Dabul1, Ashley Siryk1, Emmanuel Sturchler2, Patricia McDonald2, Walter Koch3, 1Nova Southeastern University, Ft. Lauderdale, FL, USA, 2Scripps Florida, Jupiter, FL, USA, 3Temple University, Philadelphia, PA, USA

P2 -20 Combined cardiac PPARα and PPARγ activation reduce PGC -1α gene expression and compromise binding of PPARγ on PGC -1αKonstantinos Drosatos1, Diego Scerbo2, Christian Schulze2, Ira J. Goldberg2, 1Temple University School of Medicine, Philadelphia, PA, USA, 2Columbia University, New York, NY, USA

P2 -21 Inhibition of NF -kB in the lungs prevents monocrotaline induced pulmonary hypertension in mice by modulating miR -130aSudhiranjan Gupta1, Li Li1, Chuanyu Wei1, Il -Kwon Kim1, Yvonne Janssen -Heininger2, 1Cardiovascular Institute, Texas A&M University, Temple, TX, USA, 22University of Vermont, Burlington VT, USA

P2 -22 Scleraxis regulates cardiac extracellular matrix composition and fibroblast phenotypeRushita Bagchi1,2, Patricia Roche1,2, Nina Aroutiounova1,2, Leon Espira1,2, Bernard Abrenica1,2, Ronen Schweitzer3, Michael Czubryt1,2, 1Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada, 2University of Manitoba, Winnipeg, Manitoba, Canada, 3Oregon Health and Science University, Portland, Oregon, USA

P2 -23 Hexokinase -II regulates mitochondria specific autophagy in response to ischemiaDavid Roberts1, Valerie Tan -Sah1, Shigeki Miyamoto1, 1University of California, San Diego, La Jolla, CA, USA

P2 -24 MiR -30e reduces osteogenic differentiation of bone marrow derived mesenchymal stem cells by directly targeting IGF2Wen Ding1, Jihe Li1, Samirah Gomes1, Joshua Hare1, Lina Shehadeh1, 1University of Miami Miller School of Medicine, Miami, FL, USA

P2 -25 Chronic β1 -adrenergic blockade enhances β3 -adrenergic coupling with nitric oxide -cGMP signaling in volume overloadDanielle Trappanese1, Yuchuan Liu1, Alessandro Cannavo2, Ryan McCormick1, A. Ray Dillon3, D. Michael Tillson3, Harrish Jarrett1, Felix Woitek1, Walter Koch2, Fabio Recchia1,4, Louis Dell'Italia6, Emily Tsai1,4, 1Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA, USA, 2Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA, 3College of Veterinary Medicine, Auburn University, Auburn, AL, USA, 4Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA, 5Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy, 6Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, AL, USA, 7Cardiology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA

P2 -26 Interaction between neuronal NOS signaling and temperature influences SR Ca2+ leak in cardiomyocytesRaul Dulce1, Vera Mayo1, Erika Rangel1, Wayne Balkan1, Joshua Hare1, 1Interdisciplinary Stem Cell Institute, Miami, Florida, USA

P2 -27 Defining the role of the stress sensors MLP and CARP for DCM developmentStephan Lange1, Alexander Lun1, Nancy Dalton1, Erika Alvarez1, Kirk Peterson1, Elisabeth Ehler2, Ju Chen1, 1UC San Diego, La Jolla, CA, USA, 2King's College London, London, UK

P2 -28 FGF23 -mediated activation of FGFR4 is a novel hypertrophic signaling pathway FGF23 -mediated activation of FGFR4 is a novel hypertrophic signaling pathwayAlexander Grabner1, Ansel Amaral1, Myles Wolf2, Joshua Hare3, Marcus Brand4, Axel Ullrich5, Christian Faul1, 1Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA, 2Division of Nephrology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, 3Interdisciplinary Stem Cell Institute, University of

Miami Miller School of Medicine, Miami, FL, USA, 4Department of Internal Medicine, University of Muenster, Muenster, Germany, 5Department of Molecular Biology, Max Planck Institute of Biochemistry, Munich, Germany

P2 -29 Calcium and stress modulate SERCA2 gene transcriptionJorge Fragoso -Medina1, Gabriela Rodríguez1, Ángel Zarain -Herzberg1, 1National University of Mexico, México, Distrito federal, Mexico

P2 -30 Ca2+ -dependent pathways control calsequestrin -2 expression in cardiomyocytesRafael Estrada Avilés1, Gabriela Rodríguez1, Angel Zarain Herzberg1, 1Universidad Nacional Autónoma de México, Mexico City, Mexico

P2 -31 S -nitrosylation of PPARγ regulates the balance of adipogenesis and osteogenesis in mesenchymal stem cellsYenong Cao1, Samirah Gomes3, Erika Rangal2, Wayne Balkan1, Joshua Hare1, 1University of Miami Miller School of Medicine, Miami, FL, USA, 2Albert Einstein Hospital – Instituto de Ensino e Pesquisa, Morumbi, São Paulo, SP, Brazil, 3Universidade de Sao Paulo -FMUSP, São Paulo, SP, Brazil

P2 -32 Sumo E2 ligase is required for efficient protein quality control of cardiomyocytesManish Gupta1, Jeffrey Robbins1, 1The Heart Inst, Dept of Pediatrics, The Cincinnati Children‟s Hosp Medical Ctr, Cincinnati, USA

P2 -33 p53 controls the fate of cardiac stem cellsRamaswamy Kannappan1, Eric Zhang1, Giorgia Palano1, Joao T Pereira1, Virginia Caballero1, Alex J Matsuda1, Marcello Rota1, Piero Anversa1, Annarosa Leri1, 1Brigham and Women's Hospital, Boston, MA, USA

P2 -34 The RNA binding protein HuR mediates expression of cardioprotective heat shock protein 70.3Melissa Kelley1, Stephen Kraynik1, Andrew Gabanic1, Sarah Anthony1, Michael McGuinness1, Michael Tranter1, 1University of Cincinnati College of Medicine, Cincinnati, OH, USA

P2 -35 Transgenic mice overexpressing Regulator of G protein Signaling 2: a unique model for investigating Gq/11 signaling and function in atriaJialin Su1,2, Cindy Park -Windhol1,2, Michelle King1, Peng Zhang1,2, Ulrike Mende1,2, 1Rhode Island Hospital, Providence, RI, USA, 2Brown University, Providence, RI, USA

P2 -36 MicroRNA -1: a novel inhibitor of cell cycle progression in cardiac fibroblastsMichelle King1, Nedyalka Valkov1,2, Peng Zhang1,2, 1Rhode Island Hospital, Providence, RI, USA, 2Brown University, Providence, RI, USA

P2 -37 Hypoxia dependent control of myosine heavy chain expression in heartLucia Bino1,4, Jirina Prochazkova1,3, Jana Navratilova2,3, Jiri Pachernik2, Lukas Kubala3,4, 1Institute of Experimental Biology, Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2Institute of Experimental Biology, Department of Physiology and Immunology of Animals, Faculty of Science, Masaryk University, Brno, Czech Republic, 3Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i, Brno, Czech Republic, 4St Anne's University Hospital Brno, International Clinical Research Center - Center of Biomolecular and Cellular Engineering, Brno, Czech Republic

P2 -38 The role of HIF -1α in the regulation of cardiomyogenesis in vitroJana Navratilova1,2, Jirina Prochazkova1,5, Lucia Bino4,5, Hana Kolarova1, Dominika Sykorova1,2, Pavel Karas3, Jiri Pachernik2,4, Lukas Kubala2,4, 1Institute of Biophysics ASCR v.v.i., Brno, Czech Republic, 2Institute of Experimental Biology, Deparment of Physiology and Immunology of Animals, Faculty of Science, Masaryk University, Brno, Czech Republic, 3Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic, 4St. Anne's University

Hospital Brno -International Clinical Research Center - Center of Biomolecular and Cellular Engineering, Brno, Czech Republic, 5Institute of Experimental Biology, Deparment of Histology and Embryology, Faculty of Medicine, Brno, Czech Republic

Exitation-Contraction Coupling

P2 -39 Chronic testosterone withdrawal slows calcium transient decay and prolongs contractile function in ventricular myocytes isolated from gonadectomised C57BL/6 male miceMohammad Ayaz1, Susan Howlett1, 1Dalhousie University, Halifax, Canada

P2 -40 Acute application of progesterone modifies mechanisms involved in cardiac excitation -contraction coupling in isolated murine ventricular myocytesHirad Feridooni1, Susan Howlett1, W. Glen Pyle2, 1Dalhousie, Halifax, Nova Scotia, Canada, 2University of Guelph, Guelph, Ontario, Canada

P2 -41 The impact of frailty on cardiac contractile function in an aging mouse modelMichael Sun1, Jocelyne Whitehead1, Susan Howlett1, 1Dalhousie University, Halifax, Nova Scotia, Canada

P2 -42 Endogenous HAX -1 depresses the phospholamban inhibitory activityPhilip Bidwell1, Chi Keung Lam1, George Adly1, Luke Mugge1, Erica Vanderbilt1, Evangelia Kranias1, 1University of Cincinnati, Cincinnati, OH, USA

P2 -43 The impact of ovariectomy on cAMP/PKA -dependent mechanisms involved in cardiac excitation -contraction coupling.Randi Parks1, Gibanananda Ray2, Robert Rose2, Susan Howlett1, 1Department of Pharmacology, Dalhousie University, Halifax, NS, Canada, 2Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada

P2 -44 Single Molecule Fluorescence Spectroscopy Reveals SERCA2a Structural DynamicsSandeep Pallikkuth1, Seth Robia1, 1Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA

Electrophysiology & Arrhythmias

P2 -45 State Dependent Photo -Crosslinking of IKS Using Unnatural Amino Acid MutagenesisChristopher Murray1, Yasmeen Maurice1, Jodene Eldstrom1, David Fedida1, 1University of British Columbia, Vancouver, Canada

P2 -46 Short term fasting reduces susceptibility to ischemia -induced ventricular fibrillation in the isolated rat heart in a substrate -independent mannerHugh Clements -Jewery1, 1West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia, USA

P2 -47 Predictive Biomarkers for Increased Risk of Arrhythmic Death in the Prediction of Arrhythmic Events Identified by Large -scale Plasma Proteomics ProfilingJun Qu1,2, chengjian Tu1,2, James Fallavollita1, Rebeccah Young1, Xiaomeng Shen1, John Canty1, 1University at Buffalo, Buffalo, NY, Buffalo, NY, USA, 2NY CoE in Bioinformatics and Life Sciences, Buffalo, NY, USA

P2 -48 Mitochondrial -derived reactive oxygen species promote arrhythmias and are altered by mitochondrial CaMKII activityAndrew Ackell1, Olha Koval1, Mark Anderson1, 1University of Iowa, Iowa City, IA, USA

Metabolism/Diabetes/Obesity

P2 -49 Autophagic -Lysosomal Inhibition Impairs the Performance of Cardiac Ubiquitin -Proteasome System in a p62 -Dependent MannerZongwen Tian1, Changhua Wang1, Chengjun Hu1, Yihao Tian1, Jinbao Liu2, Xuejun Wang1, 1University of South Dakota, Vermillion, SD, USA, 2Guangzhou Medical College, Guangzhou, Guangdong, China

P2 -50 Inflammatory Serine Proteases Regulate Insulin Signaling and Myocyte Death during the Development of Diabetic CardiomyopathyMikhail Kolpakov1, Xinji Guo1, Bahman Hooshdaran1, Scalia Rosario1, Steven Houser1, Abdelkarim Sabri1, Khadija Rafiq1, 1Thomas Jefferson University, Philadelphia, USA

P2 -51 ACS and gender modulate transport kinetics and esterification of exogenous long -chain fatty acid into myocardial triglycerideJoseph Goldenberg1, E. Douglas Lewandowski1, 1University of Illinois at Chicago College of Medicine, Chicago, IL, USA

P2 -52 Elevated Cardiac Glycolysis Cannot Compensate for the Decrease in Mitochondrial Oxidative Metabolism That Occurs During the Development of Diastolic Heart Failure in Dahl Salt Sensitive RatsNatasha Fillmore1, Jody Levasseur1, Cory Wagg1, Wei Wang1, Gary Lopaschuk1, 1Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada

P2 -53 Partial ROCK2 deletion protects mice from high fat diet -induced cardiac dysfunctionHesham Soliman1, Guorong Lin1, Vongai Nyamandi1, Marysol Garcia -Patino1, Julia Varela1, Girish Bankar1, Zhengping Jia2, Kathleen MacLeod1, 1Molecular & Cellular Pharmacology Group, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada, 2Department of Physiology, University of Toronto, Toronto, Canada

P2 -54 Non -targeted metabolomics analysis of Muscle Ring Finger -1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changesRanjan Banerjee1, Jun He1, Megan Quintana1, James Bain2, Christopher Newgard2, Michael Muehlbauer2, Monte Willis1, 1University of North Carolina, Chapel Hill, NC, USA, 2Duke University, Durham, NC, USA

Author Index (with Poster numbers)

Abdellatif, Maha - P1 -14, P1 -37Abrenica, Bernard - P2 -22Ackell, Andrew - P2 -48Ackerman, Michael J - P2 -09Adams, John W - P1 -45Adly, George - P1 -04, P1 -05, P2 -42Ait -Mou, Younss - P1 -26Akhnokh, Maria - P1 -41Allen, Bruce - P1 -51Alsaleh, Nasser - P1 -42Alvarez, Erika - P2 -27Amaral, Ansel - P2 -28Amiad -Pavlov, Daria - P1 -30Anderson, Mark - P2 -48Anderson, Todd - P2 -02Anthony, Sarah - P2 -13, P2 -34Anversa, Piero - P2 -33Aponte, Angel - P1 -06Aravindhan, Karpagam - P1 -52Aroutiounova, Nina - P2 -22Arteaga, Grace M - P2 -09Ayaz, Mohammad - P2 -39Bagchi, Rushita - P2 -22Baines, Christopher - P1 -34, P1 -35Bain, James - P2 -54Balkan, Wayne - P1 -08, P1 -21, P1 -24, P1 -48,

P2 -26, P2 -31Banerjee, Ranjan - P2 -54Bankar, Girish - P2 -53Bao, Weike - P1 -52Barbour, April - P1 -52Barefield, David - P1 -28Barlow, Melissa - P2 -08Basu, Ratnadeep - P1 -41Bedja, Djahida - P1 -40Bellio, Michael - P1 -24, P1 -48Berretta, Remus - P1 -22, P1 -23, P2 -11Betsch, Devin - P2 -06Bhuiyan, Md Shenuarin - P1 -07, P1 -25Bian, Jinsong - P1 -44Bidwell, Philip - P2 -42Bino, Lucia - P2 -37, P2 -38Bisetto, Sara - P1 -16Bjorndahl, Trent - P2 -02Bos, J Martijn - P2 -09Bouatra, Souhaila - P2 -02

Brabcova, Iveta - P1 -38Brand, Marcus - P2 -28Broughton, Kathleen - P1 -31Caballero, Virginia - P2 -33Cai, Wen -Feng - P1 -27Caldwell, Jessica - P1 -18Campbell, Nathaniel - P1 -40Cannavo, Alessandro - P2 -25Canty, John M - P2 -03, P2 -47Cao, Yenong - P2 -31Cardounel, Arturo - P1 -28Cervenka, Ludek - P1 -50Chen, Ju - P2 -27Chenna, Venugopal - P1 -40Chen, Xiongwen - P2 -11Chesini, Gino - P2 -08Chiba, Yumi - P1 -22Cho, Woo jung - P1 -41Chuprun, Kurt - P2 -01Chytilova, Anna - P1 -38Clements -Jewery, Hugh - P2 -46Cordero -Reyes, Andrea - P2 -10Cornea, Razvan - P1 -32Czubryt, Michael - P2 -22Dabul, Samalia - P2 -19Dalton, Nancy - P2 -27Das, Samarjit - P1 -40Davies, Oluwaseun - P1 -47Davis 3rd, Robert T - P2 -14Davis, Robert - P2 -12DeAngelis, Elena - P1 -52de Antueno, Roberto - P2 -06Dell'Italia, Louis - P2 -25Deng, Jingyuan - P1 -27de Tombe, Pieter - P1 -26Dibb, Katharine - P1 -17, P1 -18Dillon, A Ray - P2 -25Dimitrova, Kristel - P2 -18Ding, Wen - P2 -24Dixon, Ian - P2 -05, P2 -16Dockstader, Karen - P2 -15Domeier, Timothy - P1 -35Douglas, Diana - P1 -35Drahota, Zdenek - P1 -38Drosatos, Konstantinos - P2 -20Duan, Wenlan - P1 -47

Duan, Xiaotao - P2 -03Dulce, Raul - P1 -21, P2 -26Dunbar, Sandra - P2 -04Duncan, Roy - P2 -06Dunkerly, Brittany - P1 -40Duran, Jason - P1 -22, P1 -23Dyck, Jason - P2 -02Ehler, Elisabeth - P2 -27Eisner, David - P1 -18Eldstrom, Jodene - P2 -45El -Sikhry, Haitham - P1 -42Espira, Leon - P2 -22Estrada Avilés, Rafael - P2 -30Evangelista, Alicia - P1 -46Ezekowitz, Justin - P2 -02Falck, John - P1 -42Falkenham, Alec - P2 -06Fallavollita, James A - P2 -03, P2 -47Fan, Guo -Chang - P1 -27Faul, Christian - P2 -28Fedida, David - P2 -45Ferguson, Bradley S - P1 -07Feridooni, Hirad - P2 -40Ferlito, Marcella - P1 -46Filameno, Krista - P2 -05Fillmore, Natasha - P2 -52Florea, Stela - P1 -27Florea, Victoria - P1 -19, P1 -48Fragoso -Medina, Jorge - P2 -29Gabanic, Andrew - P2 -13, P2 -34Gaestel, Matthias - P1 -51Gao, Chen - P1 -02Gao, Erhe - P1 -03, P2 -01, P2 -11Garcia -Patino, Marysol - P2 -53García -Rivas, Gerardo - P2 -10Gaughan, John - P1 -22George, Jon - P2 -11Ghavami, Saeid - P2 -05Gibson, Anne - P1 -35Gillis, Marc -Antoine - P1 -51Gillispie, Gregory - P1 -32Goldberg, Ira J - P2 -20Goldenberg, Joseph - P2 -51Gomes, Samirah - P2 -24, P2 -31Gong, Jianli - P1 -02Govindan, Suresh - P1 -28Grabner, Alexander - P2 -28Greaser, Marion - P1 -26

Gruber, Simon - P1 -32Gulick, James - P1 -25Guo, Xinji - P2 -50Gupta, Madhu - P2 -12Gupta, Manish - P2 -32Gupta, Shivika - P2 -05Gupta, Sudhiranjan - P2 -21Gustafsson, Asa - - P2 -08Gutierrez -Aguilar, Manuel - P1 -35Haghighi, Kobra - P1 -05, P1 -27Hajjar, Roger J - P1 -27Halayko, Andrew - P2 -05Hammock, Bruce - P1 -41Han, Beomsoo - P2 -02Hare, Joshua - P1 -21, P1 -24, P1 -33, P1 -48, P2

-24, P2 -26, P2 -28, P2 -31Hare, Joshua M - P1 -08Hatzistergos, Konstantinos - P1 -21He, Jun - P2 -54Heller Brown, Joan - P2 -08He, Minzhen - P1 -37Heo, Seongkum - P2 -04Hershberger, Ray E - P1 -05Holt, Lucy - P1 -52Hooshdaran, Bahman - P2 -50Horn, Margaux - P1 -17Houser, Steven - P1 -22, P1 -23, P2 -11, P2 -50Howlett, Susan - P1 -15, P2 -39, P2 -40, P2 -41,

P2 -43Hsu, Karen - P1 -26Hua, Fei - P1 -44Huang, Wenrui - P1 -33Hu, Chengjun - P2 -49Hullmann, Jonathan - P2 -01Huskova, Zuzana - P1 -50Imig, John - P1 -50Irving, Tom - P1 -26Ito, Bruce R - P1 -45Jahroudi, Nadia - P1 -20Jaleel, Naser - P2 -11James, Jeanne - P1 -07, P1 -25Jansova, Hana - P2 -17Janssen -Heininger, Yvonne - P2 -21Jarrett, Harrish - P2 -25Jiang, Min - P1 -04Jia, Zhengping - P2 -53Jirkovska -Vavrova, Anna - P2 -17Jirkovsky, Eduard - P2 -17

J Matsuda, Alex - P2 -33Jolivette, Larry - P1 -52Jones, Gavin - P1 -52Jones, Kenneth - P1 -10Jucker, Beat - P1 -52Kalous, Martin - P1 -38Kanashiro -Takeuchi, Rosemeire - P1 -21, P1 -33Kannappan, Ramaswamy - P2 -33Kapiloff, Michael S - P1 -13Karas, Pavel - P2 -38Karimpour -Fard, Anis - P1 -09, P1 -10Kassiri, Zamaneh - P1 -41Kavosh, Morvarid - P2 -05, P2 -16Kazmierczak, Katarzyna - P1 -33Kelley, Melissa - P2 -13, P2 -34Kim, Il -Kwon - P2 -21Kim, Maengjo - P1 -12King, Michelle - P2 -35, P2 -36Klevstigova, Martina - P1 -50Kobayashi, Tomoyoshi - P2 -09Koch, Walter - P1 -03, P2 -01, P2 -11, P2 -19, P2

-25Kohr, Mark - P1 -36, P1 -46Kolar, Frantisek - P1 -38, P1 -50Kolarova, Hana - P2 -38Kolpakov, Mikhail - P2 -50Kopkan, Libor - P1 -50Koval, Olha - P2 -48Kovarikova, Petra - P2 -17Kranias, Evangelia G - P1 -04, P1 -05, P1 -27, P2 -

42Kraynik, Stephen - P2 -13, P2 -34Kritzer, Michael D - P1 -13Kubala, Lukas - P2 -37, P2 -38Kubo, Hajime - P1 -22, P1 -23, P2 -11Kulandavelu, Shathiyah - P1 -08, P1 -21Lam, Chi Keung - P1 -04, P1 -27, P2 -42Landesberg, Amir - P1 -30Lange, Stephan - P2 -27Lebeche, Djamel - P1 -27Lee, Timothy - P1 -01, P2 -06Legare, Jean -Francois - P1 -01, P2 -06Lencova -Popelova, Olga - P2 -17Lennie, Terry - P2 -04Lepore, John - P1 -52Leri, Annarosa - P2 -33Levasseur, Jody - P2 -52Lewandowski, E Douglas - P2 -51

Liang, Jingsheng - P1 -33Liebetrau, Christoph - P1 -28, P1 -49Li, Jihe - P2 -24Li, Jinliang - P1 -13Li, Jun - P2 -03Li, Li - P2 -21Lin, Guorong - P1 -39, P2 -53Lin, Ying -Hsi - P1 -31, P2 -07Liu, Guansheng - P1 -04, P1 -05, P1 -27Liu, Jinbao - P2 -49Liu, Yuchuan - P2 -25Lopaschuk, Gary - P2 -52Lorenzen -Schmidt, Ilka - P2 -18Lu, Long Jason - P1 -27Lun, Alexander - P2 -27Lymperopoulos, Anastasios - P2 -19Lynch, Thomas - P1 -28, P1 -49MacLeod, Kathleen M - P1 -39, P2 -53Maitra, Anirban - P1 -40Makarewich, Catherine - P2 -11Mandal, Rupasri - P2 -02Mandikova, Petra - P1 -50Marshall, Kurt - P1 -34Maurice, Yasmeen - P2 -45Mayo, Vera - P2 -26McCormick, Ryan - P2 -25McDonald, Patricia - P2 -19McGuinness, Michael - P2 -34McKinsey, Timothy A - P1 -07McLendon, Patrick M - P1 -07Medina, Elizabeth - P2 -15Menazza, Sara - P1 -06Mende, Ulrike - P2 -35Menendez, Lorena - P1 -12Mentzer, Jr., Robert M - P1 -45Miyamoto, Shelley - P1 -09, P1 -10, P2 -15Miyamoto, Shigeki - P2 -23Mohsin, Sadia - P1 -23Mojiri, Anahita - P1 -20Molkentin, Jeffery - P1 -35, P2 -11Morales, Ana - P1 -05Moser, Debra - P2 -04Muehlbauer, Michael - P2 -54Mugge, Luke - P2 -42Murphy, Elizabeth - P1 -06, P1 -36, P1 -46Murray, Christopher - P2 -45Nagalingam, Raghu - P2 -12Navratilova, Jana - P2 -37, P2 -38

Nawaito, Sherin - P1 -51Neckar, Jan - P1 -38, P1 -50Newgard, Christopher - P2 -54Noor, Mariam - P2 -12Nováková, Olga - P1 -38Nunley, Karin - P1 -09Nyamandi, Vongai - P2 -53Osinska, Hanna - P1 -07, P1 -25Oudit, Gavin Y - P1 -41, P2 -02Pachernik, Jiri - P2 -37, P2 -38Page, Brian - P2 -03Palano, Giorgia - P2 -33Pallikkuth, Sandeep - P2 -44Palmiter, Richard - P1 -12Pan, Shi - P1 -16Parks, Randi - P2 -43Park -Windhol, Cindy - P2 -35Passariello, Catherine Laura - P1 -13Paulino, Ellena - P1 -08, P1 -21Perez, Xavier - P1 -47Peterson, Kirk - P2 -27Peterson, Kurt - P1 -32Pravenec, Michal - P1 -38Pressler, Susan - P2 -04Prince, Rob - P1 -52Pritchard, Tracy - P1 -27Prochazkova, Jirina - P2 -37, P2 -38Purcell, Nicole - P2 -08Pyle, W Glen - P2 -18, P2 -40Pyttel, Lukas - P1 -49Qian, Jiang - P1 -27Quintana, Megan - P2 -54Qu, Jun - P2 -03, P2 -47Rabinowitz, Joseph - P1 -22Rafiq, Khadija - P2 -50Rangel, Erika - P2 -26, P2 -31Rattan, Sunil - P2 -05Ray, Gibanananda - P2 -43Recchia, Fabio - P2 -25Robbins, Jeffrey - P1 -07, P1 -25, P2 -32Roberts, David - P2 -23Robia, Seth - P1 -32, P2 -44Roche, Patricia - P2 -22Rodrigues, Claudia - P1 -24, P1 -48Rodríguez, Gabriela - P2 -29, P2 -30Roh, Jaroslav - P2 -17Rojas, Ana I - P1 -33Rosario, Scalia - P2 -50

Rose, Robert - P2 -43Rosin, Nicole - P1 -01, P2 -06Rota, Marcello - P2 -33Rubinstein, Jack - P1 -04Russell, Brenda - P1 -31, P2 -07Sabri, Abdelkarim - P2 -50Sadayappan, Sakthivel - P1 -28, P1 -49Samokhvalov, Victor - P1 -41, P1 -42Sanchez -Freire, Veronica - P1 -31Sanders, Michael - P1 -13Sanina, Cristina - P1 -24Sayed, Danish - P1 -14Scerbo, Diego - P2 -20Schulman, Ivonne - P1 -24, P1 -48Schulze, Christian - P2 -20Schumacher, Sarah - P1 -03Schweitzer, Ronen - P2 -22Seubert, John M - P1 -41, P1 -42Shao, Qin - P1 -40Sharp, Thomas - P1 -22, P1 -23Shehadeh, Lina - P2 -24Shen, Xiaomeng - P2 -03, P2 -47Sheu, Shey -Shing - P1 -16Sheyin, Olusegun - P1 -47Shi, Yanfen - P1 -51Silva -Platas, Christian - P2 -10Simunek, Tomas - P2 -17Siryk, Ashley - P2 -19Sivaguru, Mayandi - P1 -28Smith, Shavonn - P2 -11Sobus, Rebecca - P2 -15Solaro, R John - P1 -29, P1 -31, P2 -09, P2 -12,

P2 -14Soliman, Hesham - P2 -53Stariat, Jan - P2 -17Starosta, Timothy - P1 -22, P1 -23Stauffer, Brian - P1 -09, P1 -10, P2 -15Steenbergen, Charles - P1 -06, P1 -36, P1 -40, P1

-46Steinberg, Susan - P1 -02Stelter, Zachary - P1 -11Sterba, Martin - P2 -17Strakova, Jana - P1 -11Sturchler, Emmanuel - P2 -19Sucharov, Carmen - P1 -10, P2 -15Sucharov, Juliana - P1 -09Su, Jialin - P2 -35Sung, Miranda - P2 -02

Sun, Michael - P2 -41Suzuki, Carolyn - P1 -37Sykorova, Dominika - P2 -38Szapacs, Mathew - P1 -52Szczesna -Cordary, Danuta - P1 -33Taghavi, Sharven - P1 -22Takeuchi, Lauro - P1 -08, P1 -21Tan -Sah, Valerie - P2 -23Tardif, Jean -Claude - P1 -51Tarigopula, Madhusudhan - P2 -14Tata, Nazeen - P2 -03Taylor, Amy - P2 -08Taylor, Matthew - P1 -10Tesmer, John - P1 -03Thakur, Hrishikesh - P1 -13Thomas, David - P1 -32Tian, Rong - P1 -12Tian, Yihao - P2 -49Tian, Zongwen - P2 -49Tillson, D Michael - P2 -25Toli, Jessica - P1 -37Torre -Amione, Guillermo - P2 -10Townsend, DeWayne - P1 -11T Pereira, Joao - P2 -33Trafford, Andrew - P1 -17, P1 -18Tranter, Michael - P2 -13, P2 -34Trappanese, Danielle - P1 -22, P2 -25Troidl, Christian - P1 -28, P1 -49Tsai, Emily - P2 -25Tu, chengjian - P2 -47Udesh, Foram - P2 -11Ullrich, Axel - P2 -28Utter, Megan S - P1 -29Vafiadaki, Elizabeth - P1 -04, P1 -05Valadri, Ravinder - P1 -43Valkov, Nedyalka - P2 -36Vanderbilt, Erica - P2 -42Varela, Julia - P2 -53

Velayutham, Murugesan - P1 -28Violin, Jonathan D - P2 -14Wagg, Cory - P2 -52Walklett, Karlee - P2 -19Wang, Changhua - P2 -49Wang, Da -Zhi - P2 -12Wang, Nadan - P1 -16Wang, Wei - P2 -52Wang, William - P1 -02Wang, Xiuhua - P1 -41Wang, Xuejun - P2 -49Wang, Yibin - P1 -02Warren, Chad M - P1 -29, P2 -07, P2 -09Wei, Chuanyu - P2 -21Weissova, Romana - P1 -38Whitehead, Jocelyne - P2 -41Wieczorek, David F - P2 -14Willette, Robert - P1 -52Willis, Monte - P2 -54Wishart, David - P2 -02Woitek, Felix - P2 -25Wolf, Myles - P2 -28Wolska, Beata - P1 -31, P2 -09, P2 -12, P2 -14Wu, Joseph - P1 -31Yang, Feng Hua - P1 -41Yang, Zhi - P1 -14Young, Rebeccah - P2 -03, P2 -47Yuan, Chen -Ching - P1 -33Zarain -Herzberg, Ángel - P2 -29, P2 -30Zhang, Eric - P2 -33Zhang, Hongyu - P2 -11Zhang, Peng - P2 -35, P2 -36Zhao, Wen - P1 -04, P1 -27Zheng, Jin - P1 -44Zordoky, Beshay - P2 -02Zurmanova, Jitka - P1 -38