CURRICULUM VITAE

NAME Kevin D. WickmanCITIZENSHIP United States of AmericaADDRESS Department of Pharmacology Phone: 612.624.5966

University of Minnesota FAX: 612.625.84086-120 Jackson Hall E-mail: wickm002@umn.edu321 Church Street S.E.Minneapolis, MN 55455

EDUCATION/POSTDOCTORAL TRAINING1997 Post-doctoral fellow, Children’s Hospital/Harvard Medical School – Boston MA1995 – 1997 Post-doctoral fellow, Mayo Research Foundation – Scottsdale AZ1991 – 1995 Ph.D. Mayo Foundation for Biomedical Research (Molecular Neuroscience)1987 – 1991 B.A. Saint Olaf College (Chemistry), summa cum laude

ACADEMIC APPOINTMENTS2011 – present Professor of Pharmacology, University of Minnesota2005 – 2011 Associate Professor of Pharmacology, University of Minnesota1999 – 2005 Assistant Professor of Pharmacology, University of Minnesota1997 – 1999 Instructor in Cardiology, Children’s Hospital/Harvard Medical School

HONORS AND AWARDS2014 University of Minnesota Award for Outstanding Contributions to Postbaccalaureate,

Graduate, and Professional Education2012 – 2013 Year 1 Medical School Distinguished Teaching Award2009 – 2011 Cutting Edge Basic Research Award (CEBRA), NIDA/NIH2008 Outstanding Medical School Teacher Award2002 – 2004 McKnight Land – Grant Professorship, University of Minnesota2001 Travel fellowship – Winter Conference on Brain Research2001 Pharmaceutical Researchers and Manufacturer’s Research Starter Award

MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES1994 – present Society for Neuroscience2003 – 2005 American Society for Pharmacology and Experimental Therapeutics

SCIENTIFIC ACTIVITIES2001 – present Trainer, Neuroscienct Training in Drug Abuse PI: Dr. Virginia Seybold2001 – present Trainer, Combined MD/PhD training program PI: Dr. Yoji Shimizu2000 – present Trainer, PharmacoNeuroImmunology Training Grant PI: Dr. Tom Molitor2000 – present Member, Graduate Program in Neuroscience University of Minnesota1999 – present Member, Graduate Program in Pharmacology University of Minnesota2011 – 2015 Member, NIH NTRC study section2011 Ad hoc member, NIH Special Emphasis Panel/SRG 2011/05 ZRG1 MDCN-A(04) M2010 Ad hoc member, NIH NTRC study section2010 Ad hoc member, NIH SRG1 CB0J (03) study section2009 Ad hoc member, Biomedical Research Advisory Committee (Univ. Minnesota)2005 – 2009 Member, F03A NIH Fellowship Committee2008 Ad hoc member, NIH BPNS study section2007 Ad hoc member, NIH HLBI Program Project Review Committee PP-469

Last update: March 31, 2016 1

GRANT SUPPORT

Current

G protein-gated K + channels and inhibitory signaling Source/ID: National Institutes of Health/NIMH (RO1 MH061933)PI: WickmanPeriod: 07/01/01-1/31/17Direct costs/year: $250,000

The role of RGS proteins in the parasympathetic control of heart rateSource/ID: National Institutes of Health/NHLBI (RO1 HL105550)PI: Wickman/Martemyanov (multi-PI)Period: 01/15/11-06/30/19Direct costs/year: $128,437

Relevance and plasticity of metabotropic inhibitory signaling in reward circuitsSource/ID: National Institutes of Health/NIDA (RO1 DA034696)PI: WickmanPeriod: 08/01/13-04/30/18Direct costs/year: $221,625

Development of an in vivo, brain-penetrant GIRK1/2 potassium channel activatorSource/ID: National Institutes of HealthPI: Weaver/Hopkins/Wickman (multi-PI)Period: 07/01/15-06/30/18Direct costs/year: $114,386

Cocaine-induced adaptations in inhibitory signaling in VTA dopamine neuronsSource/ID: National Institutes of Health/NIDA (F31 DA041767)PI: Nora McCall (Wickman, sponsor)Period: 06/15/16-06/14/19

Pending

Ethanol modulation of associative learning: the role of inhibitory signaling in the basolateral amygdalaSource/ID: National Institutes of Health/NIAAA (K99 AA024473)PI: Megan Tipps (Wickman, mentor)Period: 01/01/16-12/31/18Status: This application is currently pending administrative review

Past

The role of GIRK channels in hippocampal-dependent cognition and plasticitySource/ID: National Institutes of Health/NIMH (F32 MH106190)PI: Nicole Victoria (Wickman, mentor)Period: 08/24/15-01/11/18Direct costs/year: postdoctoral fellowship

Last update: March 31, 2016 2

Basic Research Center in Molecular and Cell Biology of Drug AddictionSource/ID: National Institutes of Health/NIDA (P50 DA011806)PI: LohPeriod: 07/01/03-09/30/13

Trek channels and opioid signaling in the VTASource/ID: National Institutes of Health/NIDA (R21 DA029343)PI: WickmanPeriod: 04/01/10-03/31/12

Compartmentalization of GIRK signalingSource/ID: National Institutes of Health/NIMH (F31 MH078291)PI: Jose Colón (Wickman, mentor)Period: 10/01/06-04/01/09

GIRK4: a new obesity gene?Source/ID: Minnesota Obesity Consortium (Pilot and Feasibility Award)PI: WickmanPeriod: 10/01/06-09/30/08

GIRK4: a new obesity gene?Source/ID: University of Minnesota Graduate School (Grant-in-Aid of Research)PI: WickmanPeriod: 01/01/06-06/30/07

GIRK channels: a role in epilepsySource/ID: Epilepsy Foundation (Predoctoral Research Training Fellowship)PI: Marco Pravetoni (Wickman, mentor)Period: 01/01/06-12/31/06

Linking molecules and neuronal circuits to complex behaviorSource/ID: Minnesota Medical Foundation (Equipment Award)PI: WickmanPeriod: 03/01/05-02/28/06

Modulation of the cardiac G protein-gated K + channel Source/ID: National Institutes of Health/NHLBI (F32 HL074618)PI: Dr. Lev Koyrakh (Wickman, mentor)Period: 08/04/03-08/03/06

From analgesia to addiction: toward a molecular understanding of drug actionSource/ID: University of Minnesota (McKnight Land-Grant Professorship)PI: WickmanPeriod: 07/01/02-06/30/04

Characterization of neurotransmitter-gated potassium channelsSource/ID: University of Minnesota (Grant-in-Aid)PI: WickmanPeriod: 07/01/00-01/12/02

Last update: March 31, 2016 3

Opioid regulation of G protein-gated K + channels Source/ID: PhRMA Foundation (Research Starter Award)PI: WickmanPeriod: 01/01/01-12/31/01

Opioid and cannabinoid regulation of G protein-gated K + channels Source/ID: Minnesota Medical Foundation (Research award)PI WickmanPeriod: 05/15/00-05/14/01

Characterization of neurotransmitter-gated potassium channelsSource/ID: Minnesota Medical Foundation (Equipment award)PI: WickmanPeriod: 03/01/00-02/28/01

Last update: March 31, 2016 4

TEACHING/EDUCATION

Course directorshipsINMD 6818 Principles of Pharmacology Dates: 2003 – presentRoles: Associate Course Director (2003 – 2010)

Course Director (2011 – present)Phcl 5103 Pharmacology for Dental Students Dates: 2002 – 2003Role: Associate Course Director

Courses/lectures taughtINMD 6818 Principles of Pharmacology Topics: Pharmacodynamics (2 hr), Autonomic Pharmacology (8 hr), Eicosanoids (2 hr)Semester: summer (2002 – present)Phcl 5111 A Graduate Student’s Toolkit II Topic: Scientific writing and the NRSA application (15 hr)Semester: fall (2011 – 2013)Phcl 8217 Problems in Investigative Pharmacology Topic: Ongoing research (1 hr)Semester: fall (1999 – 2012)Phcl 8111 Advanced Pharmacology Topics: Stem cells (3 hr, 2001 – 2008), Autonomic Pharmacology (3 hr, 2008 – 2010)Semester: springPhcl 5103 Pharmacology for Dental Students Topic: Local and General Anesthetics (2 hr)Semester: spring (2002 – 2008)Phcl 5101 Pharmacology for Pharmacy Students Topic: Anti-arrythmic agents (2 hr)Semester: fall (2000 – 2004)Phcl 5100 Pharmacology for Pre-Nursing Students Topic: Local and General Anesthetics (2 hr)Semester: spring (2001 – 2004)Phcl 8208 Neuropsychopharmacology Topic: Ligand-gated ion channels (2 hr)Semester: spring (2003)

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RESEARCH MENTORSHIP

Postdoctoral associates trained/mentored/advisedLei Zhang, PhD 2015 – presentMegan Tipps, PhD 2014 – presentEzequiel Marron, PhD 2013 – presentNicole Victoria, PhD 2013 – 2015 (Individual NRSA Postdoctoral Fellowship)Nicole Wydeven, PhD 2014 – 2015Matt Hearing, PhD 2010 – 2013Devinder Arora, PhD 2007 – 2010Lev Koyrakh, PhD 2002 – 2006 (Individual NRSA Postdoctoral Fellowship)Ilham Bettahi, PhD 2002 – 2004

Predoctoral students trained/mentored/advisedAllison Anderson 2016 – presentBaovi Vo 2016 – presentNora McCall 2014 – present (Individual NRSA Postdoctoral Fellowship)Lydia Kotecki 2011 – presentNicole Wydeven 2010 – 2014 (PhD, Dissertation Fellowship, Bacaner Award, Milne-

Brandenburg Award)Kelsey Mirkovic 2009 – 2012 (PhD)Kevin Allen 2008 – 2010 (Masters, 3M Fellowship)Cydne Perry 2004 – 2008 (PhD, DOVE Fellowship)Jose Colón Sáez 2003 – 2008 (PhD, Individual NRSA Predoctoral Fellowship)Marco Pravetoni 2004 – 2008 (PhD, Epilepsy Foundation Predoctoral Fellowship)Maria Roman 2002 – 2006 (PhD, Fundacion Caixa Galicia Fellowship)Cheryl Marker 2001 – 2005 (PhD, Bacaner Research Award)

Undergraduate students and technical support staff trained/mentored/advisedAllee Schaeffer 2015 – present (Junior Scientist)Nicholas Carlblom 2014 – present (Junior Scientist)Zhilian Xia 2012 – present (Junior Scientist)Alex Shnaydruk 2014 (Junior Scientist)Jennifer Kutzke 2013 – 2014 (Junior Scientist)Matthew Novitch 2012 – 2013 (work-study, UROP* award)Daniele Young 2010 – 2013 (work-study, UROP award, Junior Scientist)Jaime Palmersheim 2011 – 2012 (Junior Scientist)Desirae M. Haluk 2008 – 2011 (Junior Scientist)Rehbein, Tyler 2011 – 2012 (Directed research)Benjamin Yun 2011 – 2012 (work-study)Tristan Driscoll 2007 – 2009 (work-study, UROP award)Felix Nwogbo 2010 (LSSURP** student)Jason Lewis 2007 – 2008 (UROP recipient)Connie Tang 2005 (LSSURP student)Jason Spurlock 2001 (UROP recipient)Stephanie Cintora 2000 – 2001 (Junior Scientist)

* UROP Undergraduate Research Opportunities Program

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** LSSURP Life Sciences Summer Undergraduate Research Program

Last update: March 31, 2016 7

SELECTED INVITED PRESENTATIONS

INTERNATIONAL/NATIONAL“GIRK channels in the reward circuitry: subunits and cell types”, Duke University, Raleigh/Durham, NC –

March 2-3, 2015“Molecular & cellular mechanisms of opioid reward”, Winter Conference on Brain Research, Big Sky, MT

– January 27-30, 2015“Plasticity and relevance of neuronal GIRK potassium channels”, University of Texas Health Science

Center, San Antonio, TX – April 6-7, 2014“New insights into the therapeutic potential of Girk channels”, The Scripps Research Institute, Jupiter, FL –

October 29, 2013“Neuronal G protein-gated K+ channels: regulation and relevance”, Brown University, Providence, RI –

March 1, 2013“Rgs6-dependent modulation of autonomic influence on cardiac output”, The Scripps Research Institute,

Jupiter, FL – March 30, 2012“G protein-gated K+ channels: structural and functional diversity, dynamic regulation, relevance”, NIEHS

– September 27, 2011“G protein-gated K+ channels: structural and functional diversity, dynamic regulation, and influence on

complex behaviors”, Department of Pharmacology Seminar Series, University of Michigan, Ann Arbor, MI – April 27, 2011

“G protein-gated K+ channels in pain and analgesia”, 2007 International Narcotics Research Conference – Berlin, Germany, July 10, 2007

“Contributions of G protein-gated potassium ion channels to complex behaviors”, University of Puerto Rico at Cayey – March 21, 2006

“Optimizing Opiates by Understanding Opioid Receptor Regulation”, Society for Neuroscience Mini-symposium, Washington, D.C. – November 12, 2005

“Genetic dissection of G protein-gated potassium channels”, Central Medical University – Geneva, Switzerland – November 6, 2004

STATE/LOCAL/UNIVERSITY“G protein-gated K+ channels in the reward circuitry: subunits, cell types, significance”, MD/PhD Program

Seminar Series, University of Minnesota, Minneapolis, MN – November 16, 2015“G protein-gated K+ channels in the reward circuitry: subunits, cell types, significance”, Graduate Program

in Neuroscience Seminar Series, University of Minnesota, Minneapolis, MN – November 2, 2015“Metabotropic inhibitory signaling: mechanisms, plasticity & relevance”, Department of Pharmacology

Research Mini-symposium, University of Minnesota, Minneapolis, MN – October 10, 2013“Neuronal G protein-gated K+ channels: regulation and relevance”, MD/PhD Program Seminar Series,

University of Minnesota, Minneapolis, MN – February 4, 2013“G protein-gated K+ channels: structural and functional diversity, dynamic regulation, relevance”, Keynote

speaker, Seventh Annual Northwest Regional Undergraduate Affiliate Network Meeting, Concordia College, Moorhead MN – October 29-30, 2011

“Neuronal G protein-gated K+ channels”, PsychoNeuroImmunology Seminar Series, University of Minnesota, Minneapolis, MN – December 2, 2010

“Cellular and behavioral phenotypes related to opioids and cocaine in mice lacking G protein-gated potassium channels”, Basic Research Center on the Molecular and Cell Biology of Drug Addiction Symposium, University of Minnesota, Minneapolis, MN – May 11, 2002

“Neuronal G protein-gated K+ channels”, Mayo Foundation Research Symposium - Rochester, MN September 25th, 2001

Last update: March 31, 2016 8

SERVICE

National2011 – 2015 Member, NIH NTRC study section2011 Member, NIH ZRG1 MDCN-A (04) (Special Emphasis Panel)2010 Ad hoc member, NIH NTRC study section2010 Ad hoc member, NIH SRG1 CB0J (03) study section 2005-2009 Member, F03A NIH Fellowship Committee2008 Ad hoc member of NIH BPNS study section2007 Ad hoc member of NIH HLBI Program Project Review Committee, PP-469

Academic Health Center/University2014 – 2015 Member, Institutional Animal Care and Use Committee (IACUC)2009 Ad hoc member, Biomedical Research Advisory Committee

Medical School2008 – present Member, Committee on Student Scholastic Standing (COSSS)2011 – present Member, Scientific Foundations Committee2011 – 2012 LCME Accreditation, Year 1 Course Director discussant2006 – 2007 Member, MED2010 Subcommittee on Mentorship2006 – 2007 Co-chair, MED2010 subcommittee on Mentorship for Integration of Knowledge2004 LCME Accreditation, Junior Faculty Representative2002 Member, Self-study committee (Graduate Program in Neuroscience)2001 – 2005 Member, Graduate Faculty Status Committee (Neuroscience)

Department of PharmacologyExecutive Committee for the Head of Pharmacology2015 – present MemberFaculty Search Committee2013 – present Chair2003 – 2004 MemberFaculty Scholarship Committee2010 – present Chair (elected)2004 – 2010 MemberPost-tenure Review Committee2007 – present Member (elected)Committee for Graduate Studies2010 – 2012 Member2001 – 2004 MemberCommittee for Seminars and Special Lectures2003 – 2004 Chair2002 – 2003 Member2000 – 2001 MemberCommittee for Professional Teaching2001 – 2004 MemberSelf-Study Committee ( ad hoc ) 2001 – 2002 Member (elected)

Last update: March 31, 2016 9

BIBLIOGRAPHYReviews and book chapters(9) Slesinger PA, Wickman K. Preface, International Review of Neurobiology: GIRK potassium channels.

Wickman K, Slesinger PA, editors. 2015; 123:xi-xii [PubMed – in process](8) Marron Fernandez de Velasco E, McCall N, Wickman K. GIRK channel plasticity and implications

for drug addiction, International Review of Neurobiology: GIRK potassium channels. Wickman K, Slesinger PA, editors. 2015; 123:201-38 [PubMed – in process]

(7) Lujan R, Marron Fernandez de Velasco E, Aguado C, Wickman K. New insights into the therapeutic potential of GIRK channels. Trends Neurosci. 2014; 37(1):20-9 [PMCID: PMC3880623]

(6) Hearing M, Zink AN, Wickman K. Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system. Rev. Neurosci. 2012; 23(4):325-51 [PMCID: PMC3723137]

(5) Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Annals N.Y. Acad. Sci. 1999; 868:386-398

(4) Picciotto MR, Wickman K. Using transgenic and knock out mice to study neurophysiology and behavior. Physiol. Rev. 1998; 78:1131-1163

(3) Wickman K, Hedin KE, Perez-Terzic CM, Krapivinsky GB, Stehno-Bittel L, Velimirovic B, Clapham DE. Mechanisms of transmembrane signaling. In: Handbook of Physiology: Cell Physiology Hoffman J, Jameison J, eds. New York: Oxford University Press, 1997: 689-742

(2) Wickman K, Clapham D. Ion channel regulation by G proteins. Physiol. Rev. 1995; 75:865-885 (1) Wickman KD, Clapham DE. G protein regulation of ion channels. Curr. Op. Neuro. 1995; 5:278-285

Manuscripts submitted for publication in peer-reviewed journals(2) Lujan R, Aguado C, Cozar J, de la Ossa L, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y.

Differential association of GABAB receptors with their downstream effector ion channels in Purkinje cells. J. Neurochem. 2015; submitted.

(1) McCall NM, Kotecki L, Dominguez-Lopez S, Marron Fernandez de Velasco E, Carlblom N, Sharpe AL, Beckstead MJ, Wickman K. Selective ablation of GIRK channels in dopamine neurons enhances behavioral effects of cocaine in mice. Neuropsychopharmacology. 2016; submitted.

Peer-reviewed publications(70) Victoria NC, Marron Ferndandez de Velasco E, Ostrovskaya O, Metzger S, Xia Z, Kotecki L,

Benneyworth MA, Zink AN, Martemyanov KA, Wickman K. G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning. Biol. Psych. 2016; in press [NIHMS730041]

(69) Munoz MB, Padgett C, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA. A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons. J. Neurosci. 2016; 36(11):3106-14 [PubMed – in process]

(68) Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni A-L, Marger L, Nargeot J, Striessnig J, Escande D, Wickman K, Charpentier F, Mangoni ME. G-protein-gated IKACh channels as therapeutic targets for treatment of sick-sinus syndrome and heart block. Proc. Natl. Acad. Sci. USA 2016; 113(7):E932-41 [PMCID: PMC4763776]

(67) Montandon G, Ren J, Victoria NC, Liu H, Wickman K, Greer JJ, Horner RL. G-protein-gated inwardly rectifying potassium channels modulate respiratory depression by opioids. Anesthesiology 2016; 124(3):641-50 [PMCID: PMC4755838]

(66) Herman MA, Sidhu H, Stouffer DG, Kreifeldt M, Le D, Cates-Gatto C, Munoz MB, Roberts AJ, Parsons LH, Roberto M, Wickman K, Slesinger PA, Contet C. GIRK3 gates activation of the

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mesolimbic dopaminergic pathway by ethanol. Proc. Natl. Acad. Sci. USA 2015; 112:7091-6 [PMCID: PMC4460485]

(65) Kotecki L, Hearing MC, McCall N, Marron Fernandez de Velasco E, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K. GIRK channel modulate opioid-induced motor activity in a cell-type and subunit-dependent manner. J. Neurosci. 2015; 35(18):7131-42 [PMCID: PMC4420781]

(64) Marron Fernandez de Velasco E, Hearing MC, Xia Z, Victoria NC, Lujan R, Wickman K. Sex differences in GABAB receptor-dependent signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex. Neuropharmacology 2015; 95:353-60 [PMCID: PMC4466052]

(63) Mesirca P, Alig J, Torrente AG, Muller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen, Nargeot J, Wickman K, Isbrandt D, Mangoni ME. Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation. Nature Commun. 2014; 5:4664 [PMCID: PMC4207211]

(62) Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K. Mechanisms underlying the activation of G protein-gated inwardly-rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. Proc. Natl. Acad. Sci. USA 2014; 111(29):10755-60 [PMCID: PMC4115558]

(61) Ostrovskaya O, Xie K, Masuho I, Fajardo-Serrano A, Luján R, Wickman K, Martemyanov KA. RGS7/G5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. eLIFE 2014; 3:e02053(doi: 10.7554/eLife.02053) [PMCID: PMC3988575]

(60) Krogh KA, Wydeven N, Wickman K, Thayer SA. HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways. J. Neurochem. 2014; 130(5):642-56 [PMCID: PMC4141023]

(59) Wydeven N, Posokhova E, Xia Z, Martemyanov K, Wickman K. RGS6, but not RGS4, is the dominant Regulator of G protein Signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. J. Biol. Chem. 2014; 289(4):2440-9 [PMCID: PMC3900986]

(58) Liang B, Nissen JD, Laursen M, Wang X, Skibsbye L, Hearing MC, Andersen MN, Rasmussen HB, Wickman K, Grunnet M, Olesen SP, Jespersen T. G-protein coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc. Res. 2014; 101(1):175-84 [PMCID: PMC3868351]

(57) Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA. Essential role of the M2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One. 2013; 8(10):e76973 [PMCID: PMC3812209]

(56) Hearing M, Kotecki L, Marron Fernandez de Velasco E, Fajardo-Serrano A, Chung HJ, Lujan R, Wickman K. Repeated cocaine weakens GABAB-Girk signaling in Layer 5/6 pyramidal neurons in the prelimbic cortex. Neuron 2013; 80(1):159-70 [PMCID: PMC3793643]

(55) Mesirca P, Marger L, Toyoda F, Rizzeto R, Dubel S, Torrente AG, DiFrancesco ML, Muller C, Leoni A-L, Couette B, Nargeot J, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J. Gen. Physiol. 2013; 142(2):113-26 [PMCID: PMC3727310]

(54) Fajardo-Serrano A, Wydeven N, Young D, Watanabe M, Shigemoto R, Martemyanov KA, Wickman K, Luján R. Association of Rgs7/G5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus 2013; 23(12):1231-45 [PMCID: PMC4060866]

(53) Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik A, Vida I. Differential GABAB-receptor mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. J. Neurosci. 2013; 33(18):7961-74 [PMCID: PMC3814621]

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(52) Wydeven N, Young D, Wickman K. Distinct structural elements in the Girk1 subunit that strengthen coupling between Girk channels and the GABAB receptor. Proc. Natl. Acad. Sci. USA 2012; 109(52):21492-7 [PMCID: PMC3535602]

(51) Mirkovic K, Palmersheim J, Wickman K. Behavioral characterization of mice lacking Trek channels. Front. Behav. Neurosci. 2012; 6:60 [PMCID: PMC3435516]

(50) Fernández-Alacid L, Watanabe M, Molnár E, Wickman K, Luján R. Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain. Eur. J. Neurosci. 2011; 34(11):1724-36 [PubMed – in process]

(49) Arora D, Hearing M, Haluk DM, Mirkovic K, Fajardo-Serrano A, Wessendorf MW, Watanabe M, Luján R, Wickman K. Acute cocaine exposure weakens GABA(B) receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area. J. Neurosci. 2011; 31:12251-7 [PMCID: PMC3174781]

(48) Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011; 11:488-97 [PMCID: PMC3184528]

(47) Mirkovic K, Wickman K. Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene. Neuroscience. 2011; 194:11-8 [PMCID: PMC3723130]

(46) Posokhova E, Wydeven N, Allen KL, Wickman K*, Martemyanov KA*. RGS6/G5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circ. Res. 2010; 107:1350-4 (*co-corresponding authors) [PMCID: PMC3014848]

(45) Arora D, Haluk DM, Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R, Wickman K. Altered neurotransmission in the mesolimbic reward system of Girk-/- mice. J. Neurochem. 2010; 114: 1487-97 [PMCID: PMC2941778]

(44) Xie K, Allen KL, Kourrich S, Colon-Saez J, Thomas MJ, Wickman K*, Martemyanov KA*. Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat. Neurosci. 2010; 13:661-3 (*co-corresponding authors) [PMCID: PMC2876203]

(43) Haluk DM, Wickman K. Evaluation of study design variables and their impact on food-maintained operant responding in mice. Behav. Brain. Res. 2010; 207:394-401 [PMCID: PMC2814880]

(42) Anderson GR, Cao Y, Davidson S, Truong HV, Pravetoni M, Thomas MJ, Wickman K, Giesler GJ Jr, Martemyanov KA. R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharm. 2010; 35:1040-50 [PMCID: PMC2887292]

(41) Kozell LB, Walter NA, Milner LC, Wickman K, Buck KJ. Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. J. Neurosci. 2009; 29:11662-73. [PMCID: PMC2813520]

(40) Fernández-Alacid L, Aguado C, Ciruela F, Martin R, Colón J, Cabañero MJ, Gassmann M, Watanabe M, Shigemoto R, Wickman K, Bettler B, Sanchez-Prieto J, Luján R. Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. J. Neurochem. 2009: 110: 1363-76 [PMCID: PMC2774143]

(39) Torrecilla M, Quillinan N, Williams JT, Wickman K. Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK knockout mice. Eur. J. Neurosci. 2008; 28:616-24 [PMCID: PMC2582177]

(38) Pravetoni M, Wickman K.  Behavioral characterization of mice lacking GIRK3/Ki3 channel subunits. Genes Brain Behav. 2008; 7:523-31.

(37) Perry C, Pravetoni M, Teske JA, Aguado C, Erickson DJ, Medrano JF, Lujan R, Kotz CM, Wickman K. Predisposition to late-onset obesity in GIRK4 knockout mice. Proc. Natl. Acad. Sci. USA 2008; 105:8148-53. [PMCID: PMC2430374]

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(36) Cruz HG, Berton F, Sollini M, Blanchet C, Pravetoni M, Wickman K*, Lüscher C*. Absence and rescue of morphine withdrawal in GIRK/Kir3 knockout mice. J. Neurosci. 2008; 28:4069-77 (*co-corresponding authors).

(35) Aguado C, Colón J, Ciruela F, Schlaudraff F, Cabañero MJ, Perry C, Watanabe M, Liss B, Wickman K, Luján R.  Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.  J. Neurochem. 2008: 105: 497-511.

(34) Smith SB, Marker CL, Perry C, Liao G, Sotocinal SG, Austin J-S, Melmed K, Clark DJ, Peltz G, Wickman K, Mogil JS.  Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogen. Genom. 2008; 18:231-241.

(33) Anderson GR, Luján R, Semenov A, Pravetoni M, Posokhova EN, Song JH, Uversky V, Chen C-K, Wickman K, Martemyanov KA. Expression and localization of RGS9-2/Gb5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. J. Neurosci. 2007; 27:14117-27.

(32) Labouèbe G, Lomazzi M, Cruz HG, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Slesinger P, Wickman K, Lüscher C. RGS2 modulates GABAB receptor-GIRK channel coupling in dopamine neurons of the ventral tegmental area.  Nat. Neurosci. 2007; 10:1559-68.

(31) Marker CL, Luján R, Colón J, Wickman K. Distinct populations of spinal cord lamina II interneurons expressing G protein-gated potassium channels. J. Neurosci. 2006: 26:12251-9.

(30) Kulik A, Vida I, Fukazawa Y, Rigato F, Bettler B, Wickman K, Frotscher M, Shigemoto R. Compartment-dependent colocalization of the Kir3.2 subunit-containing inwardly rectifying K+

channels and GABAB receptors in hippocampal CA1 pyramidal cells. J. Neurosci. 2006: 26:4289-97. (29) Koyrakh L, Luján R, Colón J, Karschin C, Kurachi Y, Karschin A, Wickman K. Molecular and

cellular diversity of neuronal G protein-gated potassium channels. J. Neurosci. 2005; 25:11468-11478.(28) Ippolito DL, Xu M, Bruchas MR, Wickman K, Chavkin C. Tyrosine-12 phosphorylation of Kir3.1 in

spinal cord is induced by acute inflammation, chronic neuropathic pain and behavioral stress. J. Biol. Chem. 2005; 280:41683-41693.

(27) Marker CL, Luján R, Loh HH, Wickman K. Spinal G protein-gated K+ channels contribute in a dose-dependent manner to the analgesic effect of mu and delta but not kappa opioids. J. Neurosci. 2005; 25:3551-59.

(26) Koyrakh L, Roman MI, Brinkmann V, Wickman K. The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated K+ channel IKACh. Am. J. Transplant. 2005; 5:529-36.

(25) Shankar H, Murugappan S, Jin J, Ding Z, Wickman K, Kunapuli SP. Role of G protein gated potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood 2004: 104:1335-1343.

(24) Beckstead MJ, Grandy DK, Wickman K, Williams JT. Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons. Neuron. 2004: 42:939-946.

(23) Marker CL, Stoffel M, Wickman K. Spinal G protein-gated K+ channels consisting of GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. J. Neurosci. 2004: 24:2806-2812.

(22) Grosse G, Eulitz D, Thiele T, Pahner I, Schroter S, Takamori S, Grosse J, Wickman K, Tapp R, Veh RW, Petter Ottersen O, Ahnert-Hilger G. Axonal sorting of Kir3.3 defines a GABA-containing neuron in the CA3 region of the rodent hippocampus. Mol. Cell. Neurosci. 2003: 24:709-24.

(21) Morgan AD, Carroll ME, Loth AM, Stoffel M, Wickman K. Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice. Neuropsychopharm. 2003; 28:932-938.

(20) Marker CL, Cintora SC, Roman MI, Stoffel M, Wickman K. Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice. Neuroreport. 2002; 13:2509-2513.

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(19) Bettahi I, Marker CL, Roman MI, Wickman K. Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. J. Biol. Chem. 2002; 277:48282-48288.

(18) Torrecilla M, Marker CL, Cintora SC, Stoffel M, Williams JT, Wickman K. G protein gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus coeruleus neurons. J. Neurosci. 2002; 22:4328-4334.

(17) Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene 2002; 248:241-250.

(16) Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of IKACh in atrial fibrillation using a mouse knockout model. J. Am. Coll. Cardiol. 2001; 37:2136-2143.

(15) Jelacic T, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G protein-gated inwardly rectifying potassium (GIRK) channels composed of GIRK2 and GIRK3. J. Biol. Chem. 2000; 275:36211-36216.

(14) Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G protein-gated potassium channel subunit, GIRK4. J. Neurosci. 2000; 20:5608-5615.

(13) Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. J. Biol. Chem. 2000; 275:12363-12366.

(12) Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. J. Biol. Chem 1999; 274:2571-2582.

(11) Nemec J, Wickman K, Clapham DE. G binding increases the open time of IKACh: Kinetic evidence for multiple G binding sites. Biophys. J. 1999; 76:246-252.

(10) Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J. Biol. Chem. 1998; 273:10811-10814.

(9) Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 1998; 20:103-114.

(8) Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics 1997; 40:395-401.

(7) Wickman K, James MF, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse ICln gene. Genomics 1997; 40:402-408.

(6) Krapivinsky GB, Krapivinsky L, Wickman K, Clapham DE. G binds directly to the G protein-gated K+ channel, IKACh. J. Biol. Chem. 1995; 270:29059-29062.

(5) Krapivinsky GB, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. J. Biol. Chem. 1995; 270:28777-28779.

(4) Krapivinsky GB, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K+-channel proteins. Nature 1995; 374:135-141.

(3) Ackerman MJ, Wickman K, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. J. Gen. Physiol. 1994; 103:153-179.

(2) Wickman KD, Iñiguez-Lluhi JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein -subunits activate the muscarinic-gated atrial potassium channel. Nature 1994; 368:255-257.

(1) Paulmichl M, Li Y, Wickman KD, Ackerman MJ, Peralta EG, Clapham DE. New mammalian chloride channel identified by expression cloning. Nature 1992; 356:238-241.

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