Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program ( ) M F...
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Transcript of Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program ( ) M F...
Cutaneous Malignant MelanomaCutaneous Malignant Melanoma
Surveillance, Epidemiology, and End Results Surveillance, Epidemiology, and End Results
(SEER) Program (www.seer.cancer.gov(SEER) Program (www.seer.cancer.gov))
M
F
Fears TR, Tucker MA.
J Natl Cancer Inst. 2005, 97:1789-90
Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS [email protected]@gwumc.edu202-994-3970202-994-3970
Photobiology of Photobiology of melanomamelanoma
• Wavelengths Wavelengths responsible-UVA, responsible-UVA, UVB or both ? UVB or both ?
• Critical Critical UV-induced molecular UV-induced molecular alterationsalterations to melanocytes ? to melanocytes ?
• PigmentPigment- protective or - protective or promotional ?promotional ?
• Role of the Role of the immuneimmune system – UV system – UV effects on immunity?effects on immunity?
Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS
Melanoma induced by UV irradiation Melanoma induced by UV irradiation of HGF/SF transgenic miceof HGF/SF transgenic mice
Noonan et al., Nature, 2001; Recio et al, Cancer Res, 2002; in prep
Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS
Functional Mc1r is necessary for Functional Mc1r is necessary for UV-induced melanomaUV-induced melanoma
YELLOW
BLACK
BLACK
Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS
Neonatal host UV irradiation promotes melanoma outgrowth
Heather Poetschke-Klug et alHeather Poetschke-Klug et al Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS
AcknowledgementsAcknowledgements
• Photobiology lab, GWUMCPhotobiology lab, GWUMC– Ed De FaboEd De Fabo– J. Bahn; research assistants and studentsJ. Bahn; research assistants and students– Agnieszka Wolnicka-Glubisz; Stephanie Agnieszka Wolnicka-Glubisz; Stephanie
Constant; Jesse DamskerConstant; Jesse Damsker
• Glenn Merlino, NCI/NIHGlenn Merlino, NCI/NIH• Miriam Anver, SAIC, FCRFMiriam Anver, SAIC, FCRF• Funding- NCI/NIH; Elaine Snyder Funding- NCI/NIH; Elaine Snyder
Cancer Research Fund, GWUMCCancer Research Fund, GWUMC
Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS