CURRICULUM VlTAE - Atlanta, GA - Emory Healthcare...James C. Ritchie, Ph.D. Page 6 CLH Committees...

CURRICULUM VlTAE

Revised: 06/04/2017

NAME: James C. Ritchie, Jr., Ph.D. OFFICE ADDRESS: Emory University Hospital, Room F-147B Department of Pathology & Laboratory Medicine 1364 Clifton Road, N.E. Atlanta, GA 30322

TELEPHONE: 404-712-7178 (EUH)

FAX: 404-712-5567

E-MAIL ADDRESS: [email protected] CITIZENSHIP: USA CURRENT TITLES AND AFFILIATIONS:

a. Academic Appointments:

Primary Appointment: Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine, 2008-Present.

Joint and Secondary Appointments: Professor, Department of Psychiatry and Behavioral Medicine, Emory University School of Medicine, 2008-Present.

b. Clinical Appointments: Director Emory Medical Laboratories, 2012 – present

Associate Director Emory Medical Laboratories, 2002 – 2012. Director, Emory Hospital Core Laboratory 2004 – present Director, Special Chemistry & Toxicology Laboratories, EUH, 1995-Present Director, Emory Immunology Laboratory, EUH, 2006 – Present Director, Emory Winship Cancer Institute Laboratory 2007 – present Director Emory Orthopedic & Spine Hospital Laboratory 2009 - present

c. Other Administrative Appointments

Co-director Clinical Chemistry Post-doctoral Training Program (2004 – present) Director, Emory Clinical Translational Research Laboratory (2007 – present) Member Pathology Department Promotion Committee (2009 – present)

PREVIOUS ACADEMIC AND PROFESSIONAL APPOINTMENTS:

Associate Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine, 2002-2007. Associate Professor, Department of Psychiatry and Behavioral Medicine, Emory University School of Medicine, 2002-2007. Assistant Professor, Department of Pathology & Laboratory Medicine, Emory University School of Medicine, 1995-2001.

James C. Ritchie, Ph.D.

Assistant Professor, Department of Psychiatry and Behavioral Medicine, Emory University School of Medicine, 1995-2001 Director, Core Laboratory, Emory Crawford Long Hospital, 1999-2003 Director, TDM Section PERL 1995-1997. Laboratory Director, Clinical Psychobiology Laboratory, Duke University; Department of Psychiatry, Durham NC, 1983-1995. Laboratory Director, Mental Health Research Institute, The University of Michigan, Ann Arbor, MI, 1978-1983. Laboratory Technician, St. Joseph Mercy Hospital, Ypsilanti, MI, 1975-1983. Research Associate, Rackham Arthritis Research Unit, The University of Michigan, Ann Arbor, MI, 1968-1978.

PREVIOUS ADMINISTRATIVE APPOINTMENTS:

Laboratory Oversight Committee, Duke University, 1991-1995. LICENSURE/BOARDS:

Laboratory Directors License, State of Georgia, 1999 to Present. SPECIALTY BOARDS:

Diplomate, (#955) American Board of Clinical Chemistry, 4/11/2001. EDUCATION:

1970 - Bachelor of Science, Zoology, The University of Michigan 1976 - Master of Public Health, Epidemiology,The University of Michigan 1995 - Doctor of Philosophy, Pharmacology, Duke University

POSTGRADUATE TRAINING: N/A MILITARY OR GOVERNMENT SERVICE: N/A COMMITTEE MEMBERSHIPS:

National and International:

AACC Proteomics Division Chairman 2008 - 2009 AACC Proteomics Division Treasurer 2005 - 2007 AACC Proteomics Division Program Committee 2006, 2008 AACC Toxicology Division Nominating Committee 2007 AACC Toxicology Division Chair - 2015 AACC Press Board 2007 - 2009 AACC Continuing Education Committee, 1987 - 1991

Chairman, AACC Continuing Education Committee, 1989 - 1991 Sec/Treas., Southeast Section AACC, 1999 – 2000 Chairman, Southeast Section AACC, 1998 NACB Secretary 2010 - 2013 NACB Publications Committee 2005 – 2007

Chairman, 2007 – 2009 ABCC Board 2010 – 2015


Academy of AACC Chairman 2017

Regional and State:

State of Georgia Laboratory Advisory Committee 1998 –2012. Chairman 2007 - 2009

Institutional:

Radiation Safety Committee I, Emory University, 1998 to present. EUH Medical Practices Committee 2012 - present

CONSULTANTSHIPS:

Abaxis, Inc 2004 – 2010 Cenrex Pharmaceuticals – 2006 Beckman / Coulter 2006 – present Castle Laboratory 2010 - present

EDITORSHIPS AND EDITORIAL BOARDS: Clinical Proteomics 2007 – Present CFTN Editorial Advisory Board 2014 - 2019

MANUSCRIPT REVIEWER:

Clinical Chemistry 2003 – present (ad hoc) Biological Psychiatry 2000 – presen (ad hoc)t Journal Clinical Psychiatry 2007 (ad hoc) Journal of Chromatography B 2007 – present (ad hoc) Neuropsychopharmacology 2006 – present (ad hoc) Clin Chem ACTA 2008 – present (ad hoc) HONORS AND AWARDS:

Univ. of Michigan Reagents Alumni Scholarship, 1964-1967. Endocrine Society Summer Student Fellowship, 1989 Travel Fellowship, Summer Neuropeptide Meeting, 1995 SOCIETY MEMBERSHIPS:

American Association for Clinical Chemistry, 1984 – Present Fellow, National Academy of Clinical Biochemistry, 2000 - Present Society for Neuroscience, 1984 - Present International Society of Psychoneuroendocrinology, 1985 - Present Society of Biological Psychiatry, 1988 - Present International Assoc. Therapeutic Drug Monitoring and Clinical Toxicology, 1997 - Present

ORGANIZATION OF NATIONAL OR INTERNATIONAL CONFERENCES:

Chairman planning committee AACC Proteomics Conference , 2006 ,2008, 2009 Chairman ACLPS meeting 2013 Workshop chair IATDMCT meeting 2013 Chairman MBDxA Conference 2013

RESEARCH FOCUS:


My research is currently focused on the pharmacokinetics/pharmacodynamics of antidepressants and anti-seizure medications during pregnancy. We are actively developing multiplexed LC/MS/MS assays to measure these drugs in small samples and various matrices. I am also persuing investigations into the use of plasma and urine proteomics as a new tool for the clinical laboratory.

PATENTS: N/A GRANT SUPPORT:

1.) Federally Funded

a. Active Support:

None b. Pending Support

None c. Previous Support:

1.-P50 MH078105-01 (P.I.: Gunnar, M. R.) 03/01/09 – 05/31/14 0.60 calendar months NIH/Inst of Child Devel. $6,613,949 (Total) Role: Principal Investigator Core Laboratory Early Experience, Stress, and Neurobehavioral Development Center (IDSC) 2 RO1 MH65737-04 (PI: Weiss, J.M.) 05/01/10 – 04/30/14 0.60 calendar months NIH/NIMH $879,750 (Total) Role: Co-Investigator Antidepressants – same effect on mesolimbic DA activity? P.I. Craighead, W.E. 07/01/08 – 06/30/13 0.60 calendar months NIH/NIMH $7,521,414 (Total) Role: Co-Investigator Predictors of Treatment Response, Relapse, and Recurrence in Major Depression

1 P50 MH087928-01A1 (P.I.: Stowe, Z). 09/01/07 – 08/31/12 2.40 calendar months NIH/NIMH. $7,741,656 (Total) Role: Principal Investigator Core C Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability MH069056 (PI: Mayberg, H) 07/01/04 – 06/30/10 0.60 calendar months NIMH $9,214,201 (Total) Role: Principal Investigator Core Laboratory The Emory-GSK-NIMH collaborative Mood Disorders Initiative RO1 MH071531 (PI: Newport, D.J.) 4/1/05 – 3/31/11 0.60 calendar months NIMH $2,628,562 (Total) Role: Principal Investigator Core Laboratrory Bipolar Disorder in Pregnancy: Predictors of Morbidity 1 P50 MH077083-01 (PI: Mayberg, H.) 04/01/06 – 03/31/11 0.60 calendar months NIH/NIMH $11,454,860 (Total) Role: Principal Investigator Core Laboratory


Predictors of Antidepressant Treatment Response: The Emory CIDAR

RO1 MH065737 (P.I.: J.M.Weiss) 12/01/02 – 11/30/05. NIH/NIMH, $566,516 (Total), Role: Co-Investigator Do Antidepressants Consistently Affect Locus Coerulrus, , Amount: P.I.: P. Pennell 10/15/03 – 7/31/05. Glaxo Smith Kline, $2,888,614 (Total) Role: Co-Investigator The Excretion of Lamotrigine into Human Breast Milk: determining Nursing Infant Daily Dose, LMC-R118, 1-RO1-HL68630-01, (P.I.: V.Vaccarino) 06/01/01 – 05/31/06 NIH/NHBLI, $ 2313,220 (Total), Role:Co-Investigator Mechanisms Linking Depression To Cardiovascular Risk: 1-RO1-MH59833-01A1 (P.I.: J.C. Ritchie), 01/01/00-12/31/04 NIH/NIMH, $555,499 (Total) Role: Principal Investigator HPA Axis Regulation and Ectopeptidase Action, 1-RO1-MH56555-01A2 (P.I.: Z. Stowe) 12/01/98 – 11/30/03 Source NIMH, $737,066 (Total) Role: Co-Investigator Predictors of Depression During Pregnancy 5-RO1-HL61703-02, (P.I.: J. R. Eckman), 7/1/99 - 5/31/02. NIH/ HBLI $705,324 (Total) Role: Co.P.I.: Effect of N-3 Fatty Acids on Sickle Cell Pain Episodes 5-RO1-MH42510-02 (P.I.: J.C. Ritchie) 09/01/87 - 08/31/89. NIH/NIMH, $297,589(Total) Role: Principal Investigator Studies of Plasma Dexamethasone Levels and the Dexamethasone Suppression Test P.I. Ritchie, J.C. 0901/03 – 08/31/04 Georgia Cancer Coalition $30,000 (Total) Role: Principal Investigator Identification of Unique Proteins and Protein Profiles in Breast Carcinoma cia SELDI-TOF mass Spectrometry P.I.: Ritchie, J.C 01/01/00-12/31/00 American Foundation for Suicide Prevention, $10,000 (Total) Folate, B Vitamins & Homocysteine Concentrations as Predictors of Treatment Outcome in Severely Depressed Older Adults.

CLINICAL SERVICE CONTRIBUTIONS:


CLH Committees 1998 – 2004 Laboratory Services, Emergency Care, Diabetes, and Surgical Services

EUH Committees: 2003 – present Medical Practice Committee Laboratory Services, Cardiac Surgery Pathway Committee ED Committee

Wesley Woods 2010 – present Medical Practice Committee

Personnel Contributions EML Laboratory Operations Committee 2007 - present

Chair EML Instrumentation Acquisition Committee 2007 Chair Laboratory Organization Subcommittee – CP Retreat 2007 Established CP Consult Service 2005 Initiated laboratory services in Medical Office Tower for Emory Clinic at CLH Developed Special Chemistry / Toxicology Laboratory Upgraded and consolidated laboratory operations at Crawford Long Hospital. Evaluated, purchased, and standardized new chemistry instrumentation (system-wide) Initiated purchase and implementation of LC/MS/MS instrumentation for Special Chemistry Instituted ComACC certified Clinical Chemistry post-doctoral training program (2004) Established Emory University Orthopedics and Spine Hospital Laboratory Established Emory Clinical Translational Research Laboratory

FORMAL TEACHING:

Medical Student Teaching Round with medical students on Pathology elective

Graduate Program: Training Program Co-Director ComACC Clinical Chemistry Post-doctoral Training Program

Residency Program: Organize and lecture in Pathology Residents CP training course. Lecture on Drugs of Abuse Measurement to Psychiatry Residents Lecture and demonstration on Steroid Measurements in the Institute on Neuroscience, Center for Behavioral Neuroscience, Summer Program (rising high school seniors) Med Tech Program Lecture on Chromatography, MS, experimental design, and general clinical chemistry Oversee Core Lab Rotation Other Clinical Chemistry and Toxicology Lecturer Emory Med Tech Certificate Program (2008 - present)

SUPERVISORY TEACHING:

Post-Doctoral Fellows Directly Supervised Dr. Laurie Sanii, Research Clinical Chemist, Chlorox Corp. Dr. Ross Molinaro – Assistant Professor, Emory Pathology


Dr. Marion Snyder – Director Toxicology, Greensboro Hospital, SC, Dr. Alex Chin – Associate Director, Calgary Laboratory Service / University of Calgary, Canada Dr. Charbel Abou Diwan Laboratory Director, Banner Good Samaritan Medical Center, Pheonix , AZ Dr. Tiffany Roberts-Wilson – Associate Director HLA Lab, University of Toronto, Ont, CA Dr. Janetta Bryskin - Lab Director Sterling Reference Labs, Tacoma, WA) Dr. Jamie Noguez - Associate Director Chemistry Case Western Hospital , Cincinnati, OH)) Dr. Emily Ryan - Laboratory Director = Macon, GA Dr. Matthew Feldhammer (2nd year) Residency Program:

Pathology Residents rotation in Clinical Chemistry,Toxicology, and Core Lab operations. Clinical Chemistry Postdoctoral Training Program (two fellows).

LECTURESHIPS, SEMINAR INVITATIONS, AND VISITING PROFESSORSHIPS: N/A INVITATIONS TO NATIONAL OR INTERNATIONAL CONFERENCES:

"The Dexamethasone Suppression Test, Psychiatry, and the Clinical Laboratory," 40th National Meeting, American Association for Clinical Chemistry, New Orleans, LA, 1988. "The Clinical Laboratory, Psychiatry and the Dexamethasone Suppression Test," 41st National Meeting, American Association for Clinical Chemistry, Atlanta, GA, 1989. "Psychiatry and the Laboratory: What's New in Depression Testing," 42nd Annual Meeting and XlV International Congress of Clinical Chemistry, American Association for Clinical Chemistry, San Francisco, , CA, 1990. "Plasma Dexamethasone and the DST", 5th World Congress: World Federation of Societies of Biological Psychiatry, Florence, Italy, 1991. "Psychiatry and the Laboratory: What's New in Depression Testing," 43rd National Meeting, American Association for Clinical Chemistry, Washington, D.C, 1991. “Psychiatric Diagnostic Testing: Depression Update,” 45th National Meeting, American Association for Clinical Chemistry, New York, NY, 1993. “Neuropepides and their Receptors in Brain as Targets for New Neuropsychiatric Drugs,” Symposium Co-Chairman: 6th World Congress, World Federation of Societies of Biological Psychiatry, Nice, France, 1997. “Antidepressants and Antiepileptics in Pregnancy,” Workshop Chairman, 9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Louisville, KY, 2005. “Pregnancy, Lactation, and the TDM of Psychotropic Medications”, 10th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Nice FR, 2007 “Validating Iothalamate Clearance to Measure GFR by LC/MS/MS”, 10th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Nice FR, 2007 “A Routine UPLC Method for the Newer Antipsychotics” 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Montreal, Canada,, 2009 “A Routine UPLC Method for the Newer Antidepressants” 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Montreal, Canada,, 2009


“The Disposition of Antiepileptic Drugs: In Ppregnancy and Beyond 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Montreal, Canada,, 2009 “TDM of Atypical Antipsychotic Drugs in Pregnant bipolar Patients”, 12th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Stutgart, Germany,, 2011 “Therapeutic drug monitoring of antiepileptic drugs during pregnancy”, 20th IFCC – EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EUROMED), Milan, Italy , 2013

OTHER ACTIVITIES: N/A BIBLIOGRAPHY: a. PUBLICATIONS IN SClENTIFIC JOURNALS:

1. Castor, C,W., Rowe, K., Dorstewitz, E., Ritchie, J.C. (1970). Regulation of collagen and hyaluronate formation in human synovial fibroblast cultures. J. Lab. and Clin. Med, 755:798-881.

2. Castor, C.W., Ritchie, J.C., et al. (1971). Abnormalities of connective tissue cells cultured from

rheumatoid arthritis. J. Lab. and Clin. Med., 77:665-675. 3. Castor, C.W., Dorstewitz, E., Smith, S.F., Ritchie, J.C. (1971). Connective tissue activation I.

Arthritis and Rheumatism, 14:41-54. 4. Castor, C.W., Smith, S.F., Ritchie, J.C., et al. (1971). Connective tissue activation II. Arthritis and

Rheumatism, 14:55-65. 5. Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith, S.F. (1972). Connective tissue activation III. J.

Lab. and Clin. Med., 79:285-301. 6. Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith, S.F. (1972). Connective tissue activation IV.

Arthritis and Rheumatism, 15:504-510. 7. Castor, C.W., Dorstewitz, E., Ritchie, J.C., Smith S.F. (1973). Connective tissue activation V. J.

Lab. and Clin. Med., 81:95-99. 8. Castor, C.W., Smith, S.F., Ritchie, J.C., Scott, M.D. (1972). Connective tissue activation:

Mechanism and Significance. Biology of the Fibroblast, 483-499. Proceedings of the Juselius Foundation Symposium, August.

9. Castor, C.W., Ritchie, J.C., et al. (1974). Connective tissue activation VI. J. Lab. and Clin. Med.,

83:45-55. 10. Castor, C.W., Ritchie, J.C., et al. (1975). Connective tissue activation VII. J. Lab. and Clin. Med.,

85:392-404. 11. Castor, C.W., Scott, M.E., Ritchie, J.C., et al. (1975). Connective tissue activation IX. Arthritis

and Rheumatism, 18:451-560. 12. Castor, C.W., Ritchie, J.C., Scott, M.E., et al. (1977). Connective tissue activation Xl. Arthritis

and Rheumatism, 220:859-868. 13. Ritchie, J.C., Smith, S.F., Castor, C.W. (1977). Measurement of urinary and serous-luid

glycosaminoglycans and urinary-hydroxyproline. Amer. J. Clin. Path., 67:5855-590.


14. Castor, C.W., Ritchie, J.C., et al. (1979). Connective tissue activation XIV. Arthritis and

Rheumatism, 22:260-272. 15. Carroll, B.J., Schroeder, K., Ritchie, J.C., et al. (1980). Plasma dexamethasone concentrations and

cortisol suppression response in patients with endogenous depression. J. Clin. Endocrinol. Metab., 51:433-437.

16. Ritchie, J.C., Carroll, B.J. (1981). Melanchollic patients: A new test to identify depression. Lab.

World, 32:25-29. 17. Privitera, M.RR., Greden, J.F., Ritchie, J.C., et al. (1982). Interference by Carbamazepine with the

Dexamethasone Suppression Test. Biological Psychiatry, 17:599-608. 18. Ritchie, J.C., Carroll, B.J. (1982). The dexamethasone suppression test in psychiatric diagnosis.

Lab. Management, 20:41-51. 19. Wilens, T.E., Ritchie, J.C., Carroll, B.J. (1984). Comparison of plasma cortisol and corticosterone

in the dexamethasone suppression test for melancholia. Psychoneuroendocrinology, 9:45-55. 20. Ritchie, J.C., Carroll, B.J., Olton, P.R., Shively, V.S., Feinberg, M. (1985). Plasma cortisol

determination for the dexamethasone suppression test. Comparison of competitive protein binding and commercial radioimmunoassay methods. Arch. Gen. Psych., 42:493-497.

21. Chappell, P.B., Smith, M.A., Kilts, C.D., Bissette, G., Ritchie, J.C., et al. (1986). Alterations in

CRF-like immunoreactivity in discrete rat blain regions after acute and chronic stress. J. Neurosci., 6:2908-2914.

22. Goldstein, D., Gockerman, J., Krishnan, K.R.R., Ritchie, J.C., et al. (1987). Effects of

gamma-interferon on the endocrine system: Results from a Phase I study. Cancer Res., 47:6397-6399.

23. Liu, P.K., Bissette, G., Ritchie, J.C. (1987). Optimization off the solid phase extraction of plasma

CRH for subsequent RIA analysis. Neuroendo, Let., 2: 177-179. 24. Krishnan, K.R.R., Manepalli, A.N., Ritchie, J.C., et al. (1988). Growth hormone-releasing factor

stimulation test in depression. Am. J. Psych., 145:90-92

25. Krishnan, K.R.R., Manepalli, A.N., Ritchie, J.C., et al. (1988). Growth hormone -releasing factor stimulation test in depression. Peptides, 2 (Suppl 1):113-116.

26. Naylor, M.R., Krishnan, K.R.R., Manepalli, A.N., Ritchie, J.C., et al. (1988). Circadian rhythm of

adrenergic regulation of adrenocorticotropin and cortisol secretion in man. J. Clin. Endocrinol. Metab., 67:404-406.

27. Antelman, S.M., Knopf, S., Kocan, D., Edwards, D.J., Ritchie, J.C., Nemeroff, C.B. (1988). One

stressful event blocks multiple actions of diazepam for up to at least a month. Brain Research, 445:380-385.

28. Goldstein, D., Nishita, J.K., Ritchie, J.C., Kuhn, C.M., Ellinwood, E.H., Laszlo, J. (1988).

Pituitary-adrenal responses to chemotherapy and antiemetics. The Cancer Jour., #2:25-29, Jan-Feb. 29. Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Nemeroff, C.B., Carroll, B.J. (1988).

Adrenocortical sensitivity to ACTH in humans. Biological Psychiatry, 24: 105-108. 30. Krishnan, K.R.R., Hayman, A., Ritchie, J.C., Utley, C.M., Dawson, D.V., Rogers, H. (1988).

Depression in early-onset alzheimer's disease: Clinical and neuroendocrine correlates. Biological Psychiatry, 24:937-940.


31. Smith, M.A., Davidson, J., Ritchie, J.C., Kudler, H., Lipper, S., Chappell, P., Nememff, C.B.

(1988). The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biological Psychiatry, 26:349-355.

32. Sundar, S.K., Becker, K.J., Fleener, S.L., Cierpial, M.A., Ritchie, J.C., Weiss, J.M. (1989).

Intracerebral infusion of Interleukin-l rapidly decreases peripheral cellular immune responses. Proc. Natl. Acad. Sci., USA, 86:6398-6402.

33. Li, S.W., Ritchie, J.C., Carroll, B.J. (1989). Plasma corticosterone in the dexamethasone

suppression test on depressed patients. Proc. Chinese Acad. of Med. Sci. and PUMC., 4;2, 72-74. 34. Nemeroff, C.B., Krishnan, K.R.R., Belkin, B.M., Ritchie, J.C., Clark, C., Vale, W.W., Rivier,

J.E., Thorner, M.O. (1989). The growth hormone response to GHRF in alzheimer's disease. Neuroendocrinology, 50:663-666.

35. Ritchie, J.C., Belkin, B.M., Krishnan, K.R.R., Nemeroff, C.B., Carroll, B.J. (1990). Plasma

dexamethasone concentrations and the dexamethasone suppression test. Biological Psychiatry, 27:159-173.

36. Kayganich, K., Watson, J.T., Kilts, C., Ritchie, J.C. (1990). Determination of plasma

dexamethasone by chemical oxidation and electron capture negative ionization mass spectrometry. Jour. of Biomedical and Environ. Mass Spectrometry, 19:341-347.

37. Krystal, A., Krishnan, K.R.R., Raitiere, M., Poland, R., Ritchie, J.C., Dunnick, N.R., Hanada, K.,

Nemeroff, C.B. (1990). The differential diagnosis and pathophysiology of Cushing's Syndrome and Primary Affective Disorder. Jour. Neuropsychiatry and Clin. Neurosciences, 2:34-43.

38. Krishnan, K.R.R., Ritchie, J.C., Saunders, W., Wilson, W., Nemeroff, C.B., Carroll, B.J. (1990).

Nocturnal and early morning secretion of ACTH and cortisol in humans. Biological Psychiatry, 28:47-57.

39. Krishnan, K.R.R., Ritchie, J.C., Sauunders, W.B., Nemeroff, C.B., Carroll, B.J. (1990).

Adrenocortical sensitivity to low-dose ACTH administration in depressed patients. Biological Psychiatry, 27:930-933.

40. Sundar, S.K., Cierpial, M.A., Kilts, C., Ritchie, J.C., Weiss, J.M. (1990). Brain IL-l induced

immunosuppression occurs through activation of both pituitary-adrenal axis and the sympathetic nervous system by corticotropin releasing factor. Jour. Neurosci., 10,#11:3701-3706.

41. Weiss, J.M., Sundar, S.K., Cierpial, M.A., Ritchie, J.C. (1991). Effects of IL-1 infused into brain

are antagonized by Alpha-Melanocyte Stimulating Hormone (a-MSH) in a dose dependent manner. Eur. Jour. Pharmacol., 192: 177-179.

42. Roy-Byrne, P.P., Cowley, D.S., Hommer, D., Ritchie, J.C., Greenblatt, D., Nemeroff, C.B. (1991).

Neuroendocrine effects of diazepam in panic and generalized anxiety disorders. Biological Psychiatry, 30:73-80.

43. Gupta, S.K., Krishnan, K.R.R., Ellinwood, E.H., Ritchie, J.C., Nemeroff, C.B. (1991).

Pharmacokinetics of human growth hormone response to growth hormone releasing factor. Life Science, 47:1887-1893.

44. Owens, M.J., Knight, D.R., Ritchie, J.C., Nemeroff, C.B. (1991). The 5-HT2 Agonist (±)-1 (2,5-

dimethyl-4-bromophenyl)-2-aminopropane (DOB) stimulates the hypothalamic pituitary-adrenal (HPA) Axis: II. Biochemical and physiological evidence for the development of tolerance after chronic administration. Jour. Pharmacol. Exp. Ther., 256:795-800.


45. Owens, M.J., Knight, D.L., Ritchie, J.C., Nemeroff, C.B. (1991). The 5-HT2 Agonist (±)-1 (2,5-

dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neuron in the rat brain. Jour. Pharmacol. Exp. Ther., 256:787-794.

46. Owens, M.J., Overstreet, D.H., Knight, D.L., Rezvani, A.H., Ritchie, J.C., Bissette, B.G.,

Janowsky, D.S., Nemeroff, C.B. (1991). Alterations in the hypothalamic-pituitary adrenal Axis in a proposed animal model of depression with genetic muscarinic supersensitivity. Neuropsychopharmacology, 4:87-93.

47. Sundar, S.K., Cierpial, M.A., Ritchie, J.C., Weiss, J.M., et al. (1991). Human immunodeficiency

virus glyoprotein (GP-120) infused into rat brain induces IL-l to eliminate pituitary-adrenal activity and decrease peripheral cellular immune responses. proc. Natl. Acad. Sci., USA, 88:11246-11250.

48. Paris, J.M., Lorens, S.A., Lee, J.M., Mitsushio, H., Ritchie, J.C., Nemeroff, C.B. (1991).

Muscimol injections into the median raphe nucleus increase serum ACTH and corticosterone concentrations via a non-serotonergic mechanism. Pharmacol. Biochem. Behav., 39:765-768.

49. Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Saunders, W., Li, S.W., Venkataraman, S.,

Nemeroff, C.B., Carroll, B.J. (1991). Fast feedback regulation of ACTH by cortisol. Prog. Neuropsychopharmacol. Biological Psychiatry, 15:523-529.

50. Potts, N.L.S., Davidson, J.R.T., Krishnan, K.R.R., Doraiswamy, P.M., Ritchie, J.C. (1991). Levels

of urinary free cortisol in social phobia. J. Clin. Psychiatry, 52: 41-42. 51. Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1992). 5a-Pregnane-3a,21-diol-20-one (THDOC)

attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Brain Research, 573:353-355.

52. Gupta, S.K., Ritchie, J.C., Wiedemann, K., Holsboer, F. (1992). Modeling the pharmacokinetics

and pharmacodynamics of dexamethasone in depressed patients. Eur. Jour. Clin. Pharmaco1., 43:51-55.

53. Ritchie, J.C., Owens, M.J., Mayer, H., Watson, J.T., Kilts, C., Carroll, B.J. (1992). Preliminary

studies of 6,B-Hydroxy-Dexamethasone and its importance in the DST. Biological Psychiatry, 32:825-833.

54. Krishnan, K.R.R., Reed, D.R., Wilson, W.H., Saunders, W., Ritchie, J.C., Nemeroff, C.B.,

Carroll, B.J. (1992). RU-486 in Depression. Prog. Neuropsycho-pharmacol. Biological Psychiatry, 16:913-920.

55. Axelson, D.A., Doraiswamy, P.M., Boyko, O.B., Escalona, P.R., McDonald, W.M., Ritchie, J.C.,

et al. (1992). In Vivo Assessment of pituitary volume with magnetic resonance imaging and systematic stereology: Relationship to dexamethasone suppression test results in patients. Psychiatry Research, 46:63-70.

56. Krishnan, K.R.R., Miller, M.N., Helms, M.J., Reed, D., Ritchie, J.C., et al. (1993). Dose response

relationship between plasma ACTH and cortisol after the infusion of ACTH 1-24. Eur. Arch. Psychiat. & Clin. Neurosci., 242:240-243.

57. Blazer, D.G., Malmrose, L.C., Wallsten, S.M., Nemeroff, C.B., Reed, D., Ritchie, J.C., Tyrey,

R.N. (1993). Rhythmicity and response to AM and PM CRH challenge in elderly subjects. Neurobiol. of Aging, 14:101-106.


58. Coffey, C.E., Wilkinson, W.E., Weiner, R.D., Ritchie, J.C., Aque, M. (1993). The dexamethasone

suppression test and quantitative cerebral anatomy in depression. Biological Psychiatry, 33:442-449.

59. Burke, M.A., McEvoy, J.P., Ritchie, J.C. (1994). A pilot study of a structured interview

addressing sexual function in men with schizophrenia. Biological Psychiatry, 35: 32-35. 60. Wall, T.L., Nemeroff, C.B., Ritchie, J.C., Ehlers, C.L. (1994). Cortisol responses following

placebo and alcohol in Asians with different ALDH2 genotypes. Journal of Studies on Alcohol, 55:207-213.

61. Cowley, D.S., Roy-Byrne, P.P., Radant, A., Ritchie, J.C., et al. (1995). Benzodiazepine sensitivity

in panic disorder: Effects of chronic alprazolam treatrnent. Neuropsychopharmacology, 12:147-157.

62. Krishnan, K.R.R., Rayasam, K., Reed, D., Smith, M., Chapell, P., Saunders, W.B., Ritchie, J.C.,

Carroll, B.J., Nemeroff, C.B. (1993). The corticotropin releasing factor stimulation test in patients with major depression: Relationship to dexamethasone suppression test results. Depression, 1: 133-136.

63. Krishnan, K.R.R., Ritchie, J.C., Tupler, L.A., McDonald, W.M., Knight, D., Nemeroff, C.B.,

Marcovina S. (1994). Apolipoprotein E-,4. [letter] Neurology, 44:2420-2421. 64. McCall, W.V., Weiner, R.D., Carroll, B.J., Shelp, F.E., Ritchie, J.C., Austin, S., Norris, J. (1996).

Serum prolactin, electrode placement, and the convulsive threshold during ECT. Convulsive Therapy, 12(2):81-85.

65. Slotkin, T.A., McCook, E.C., Ritchie, J.C., Seidler, F.J. (1996). Do glucocorticoids contribute to

the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological Psychiatry, 40:576-584.

66. Krishnan, K.R.R., Tupler, L.A., Ritchie, J.C., McDonald, W.M., Knight, D.L., Nemeroff, C.B.,

Carroll, B.J. (1996). Apoliprotein E-,4 frequency in geriatric depression. Biological Psychiatry, 40:69-71.

67. Slotkin, T.A., McCook, E.C., Ritchie, J.C., Carroll, B.J., Seidler, F.J. (1997). Serotonin transporter

expression in rat brain regions and blood platelets: Aging and glucocorticoid effects. Biological Psychiatry, 41:172.

68. Cassidy, F., Ritchie, J.C., Carroll, B.J. (1998). Plasma dexamethasone concentrations and cortisol

response during manic episodes. Biological Psychiatry, 43:747-754. 69. Slotkin, T.A., Seidler, F.J., Ritchie, J.C. (1998). Effects of aging and glucocorticoid treatment on

monoamine oxidase subtypes in rat cerebral cortex: Therapeutic Implications. Brain Research Bulletin, 47:345-348.

70. Radke, J.M., Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1998). Atypical antipsychotic drugs

selectively increase neurotensin efflux in dopamine terminal regions. Proc. Natl. Acad. Sci. (USA), 95:11462-11464.

71. Ritchie, J.C. (1999). Homocysteine and neuropsychiatric disorders. Diagnostic Endo, Immuno,

and Metab., 17:35-38. 72. Weber, C.J. and Ritchie, J.C. (1999). Retrospective analysis of sequential changes in serum intact

parathyroid hormone (PTH) levels during conventional parathyroid exploration. Surgery 126:1139-1144.


73. Stowe, Z.A., Cohen, L.S., Hostetter, A., Ritchie, J.C., Owens, M.J., Nemeroff, C.B. (2000).

Paroxetine in human breast milk and nursing infants. Amer. Jour. Psychiatr. 157:2:185-189. 74. McCune, J.S., Hawke, R.L., LeCluyse, E.L., Gillenwater, H.H., Hamilton, G., Ritchie, J.C.,

Lindley, C. (2000). In-vivo and in-vitro induction of human cytochrome P4503A4 by dexamethasone. Clin Pharmacol Ther. 68:356-366.

75. Cassidy, F., Ritchie, J.C., Verghese, K., Carroll, B.J. (2000). Dexamethasone metabolism in

dexamethasone suppression test suppressors and nonsuppressors. Biol Psychiatry. 47:677-680. 76. Slotkin, T.A., Seidler, F.J., Ritchie, J.C. (2000) Regional differences in brain monoamine oxidase

subtypes in an animal model of geriatric depression: Effects of olfactory bulbectomy in young versus aged rats. Brain Research 882:149-154.

77. Rose, J.E., Behm, F.M., Ramsey, C., Ritchie, J.C.. (2001) Platelet monoamine oxidase, smoking

cessation and tobacco withdrawal symptoms. Nicotine and Tobacco Research 3: 383-390. 78. Newport, D.J., Heim, C., Owens, M.j., Ritchie, J.C., Ramsey, C.H., Bonsall, R., Miller, A.H.,

Nemeroff, C.B. (2003) Cerebrospinal fluid corticotrophin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: A multiple regression analysis. Neuropsychopharmacology 28:569-576.

79. Ritchie, J.C., Davis, T.P., Nemeroff, C.B. (2003). Action of three ectopeptidases on corticotropin-

releasing factor: Metabolism and functional aspects. Neuropsychopharmacology 28: 22-33.

80. Stowe, Z.N., Hostetter, A.L., Owens, M.J., Ritchie, J.C., Sternberg, K., Cohen, L.S., Nemeroff, C.B. (2003) The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. J Clin Psychiatry, 64:73-80.

81. Hostetter, A.L., Stowe, Z.N., Cox, M., Ritchie, J.C. (2004) A novel system for the determination of

antidepressant concentrations in human breast milk. Therapeutic Drug Monitoring 26: 47-52.

82. Pomara, N., Willoughby, L.M., Ritchie, J.C., Sidtis, J.J., Greenblatt, D.J., Nemeroff, C.B. (2004) Interdose elevation in plasma cortisol during chronic treatment with alprazolam but not lorazepam in the elderly. Neuropsychopharmacology 29:605-611.

83. Watson, S., Gallagher, P., Ritchie, J.C., Ferrier, I.n., Young, A.H., (2004) Hypothalamic-pituitary-

adrenal axis function in patients with bipolar disorder. Br J Psychiatry, 184:496-502.

84. Choi, W.W., Srivatsa, S., Ritchie, J.C. (2005) Abberrant thyroid testing results in a clinically euthryoid patient who had received a tumor vaccine. Clin Chem 51: 673-675.

85. Mendrinos, S., Nolan, J.L., Styblo, T., Carlson, G., Pohl, J., Lewis, M., Ritchie, J. (2005) Cytologic

findings and protein expression profiles associated with ductal carcinoma of the breast in ductal lavage specimens using surface-enhanced laser desorption and ionization-time of flight mass spectrometry. Cancer. 105:178-183.

86. Wright, J.M., Ritchie, J.C., Mullins, R.E., Kellerman, A.L., Denson, D.D. (2005) Steady-state

serum concentrationsof progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury. J Clin Pharmacol 45: 640-648.


87. Weiss, J.M., Boss-Williams, K.A., Moore, J.P., Demetrikopoulos, M.K., Ritchie, J.C., West, C.H.

(2005) Testing the hypothesis that locus coeruleus hyperactivity produces depression-related changes via galanin. Neuropeptides, 39: 281-287.

88. Pomara, N., Willoughby, L.M., Ritchie, J.C., Sidtis, J.J., Greenblatt, D.J., Nemeroff, C.B. (2005)

Sex-related elevation in cortisolduring chronic treatment with alprazolam associated with enhanced cognitive performance. Psuchopharmacology, 182: 414-419.

89. Newport, D.J., Viguera, A.C.,Beach, A.J., Ritchie, J.C., Cohen, L.S., Stowe, Z.N. (2005) Lithium

placental passage and obstetrical outcome: implications for clinical management during late pregnancy. Am J Psychiatry, 162: 2162-2170.

90. Lubbock, L.A., Goh, A., Ali, S., Ritchie, J., Whooley, M.A., (2005) Relation of low socioeconomic

status to C-reactive protein in patients with coronary heart disease (from the heart and soul study). Am J Cardiol, 96:1506-1511.

91. Loughhead, A.M., Stowe, Z.N., Newport, D.J., Ritchie, J.C., DeVane, C.L., Owens, M.J. (2006)

Placental passage of tricyclic antidepressants. Biol Psychiatry, 59:287-290.

92. Loughhead, A.M., Fisher, A.D., Newport, D.J., Ritchie, J.C., Owens, M.J., DeVane, C.L., Stowe, Z.N. (2006) Antidepressants in amniotic fluid:another route of fetal exposure. Am J Psychiatry, 163: 145-147.

93. Watson, S., Thompson, J.M., Ritchie, J.C., Nicol-Ferrier, J., Young, A.H., (2006)

Neuropsychological impairment in bipolar disorder: the relationship with glucorticoid receptor function. Bipolar Disord, 8: 85-90.

94. Horton, G.L., Jortani, S.A., Ritchie, J.C., Valdes, R., Chan, D.W., (2006) Proteomics: a new

diagnostic frontier. Clin Chem, 52: 1401-1423. 95. Khwaja FW. Nolen JD. Mendrinos SE. Lewis MM. Olson JJ. Pohl J. Van Meir EG. Ritchie J.C..

Brat DJ. (2006) Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers. Proteomics. 6(23):6277-87.

96. Sheppard CA. Channell C. Ritchie JC. Duncan A. (2006) Preanalytical variables in coagulation

testing. [Letter] Blood Coagulation & Fibrinolysis. 17(5):425-6 97. Devane, CL, Stowe, ZN, Donovan, JL, Newport, DL, Pennell, PB, Ritchie, JC, Owens, MJ, Wang,

JS (2006) Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities. J Psychopharmacol. 220(4Suppl) 54-9.

98. Viguera AC. Newport DJ. Ritchie JC. Stowe Z. Whitfield T. Mogielnicki J. Baldessarini RJ. Zurick

A. Cohen LS (2007). Lithium in breast milk and nursing infants: clinical implications. American Journal of Psychiatry. 164(2):342-5

99. Vaccarino V. Brennan ML. Miller AH. Bremner JD. Ritchie JC. Lindau F. Veledar E. Su S.

Murrah NV. Jones L. Jawed F. Dai J. Goldberg J. Hazen SL. (2008) Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biological Psychiatry. 64(6):476-83.


100.Newport DJ. Pennell PB. Calamaras MR. Ritchie JC. Newman M. Knight B. Viguera AC.

Liporace J. Stowe ZN. (2008) Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics. 122(1):e223-31.

101.Pennell PB. Peng L. Newport DJ. Ritchie JC. Koganti A. Holley DK. Newman M. Stowe ZN

(2008) Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology. 70(22 Pt 2):2130-6.

102.Newport DJ. Ritchie JC. Knight BT. Glover BA. Zach EB. Stowe ZN (2009) Venlafaxine in

human breast milk and nursing infant plasma: determination of exposure. Journal of Clinical Psychiatry. 70(9):1304-10

103.West CH. Ritchie JC. Boss-Williams KA. Weiss JM (2009) Antidepressant drugs with differing

pharmacological actions decrease activity of locus coeruleus neurons. International Journal of Neuropsychopharmacology. 12(5):627-41.

104.Juric S. Newport DJ. Ritchie JC. Galanti M. Stowe ZN.(2009) Zolpidem (Ambien) in pregnancy:

placental passage and outcome. Archives of Women's Mental Health. 12(6):441-6. 105.Rodriguez H, Tezak Z, Mesri M, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler CR,

Phillip R, Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E, Ritchie, JC (as a workshop participant). (2010) Analytical validation of protein-based multiplex assays: A workshop report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics. Clin Chem 56(2):237-243.

106.West CH, Ritchie JC, Weiss JM. (2010) Addendum: Paroxetine-induced increase in activity of

locus coeruleus neurons in adolescent rats: Implication of a countertherapeutic effect of an antidepressant. Neuropsychopharmacology, 35(8):1836-1837

.

107.Bunch DR, Heideloff C, Ritchie JC, Wang S (2010) A fast and simple assay for busulfan in serum or plasma by liquid chromatography-tandem mass spectrometry using turbulent flow online extraction technology. J Chromatogr B Analyt Technol Biomed Life Sci. Dec 1;878(31):3255-8

108.Ofotokun I, Lennox JL, Eaton ME, Ritchie JC, Easley KA, Masalovich SE, Long MC,

Acosta EP. (2011) Immune activation mediated change in alpha-1-acid glycoprotein: impact on total and free lopinavir plasma exposure. J Clin Pharmacol. Nov;51(11):1539-48.

109Abou-Diwan C, Sniecinski RM, Szlam F, Ritchie JC, Rhea JM, Tanaka KA, Molinaro RJ. (2011)

Plasma and cerebral spinal fluid tranexamic acid quantitation in cardiopulmonary bypass patients. J Chromatogr B Analyt Technol Biomed Life Sci. Mar 1;879(7-8):553-6

110.Smith AK, Jeffrey Newport D, Ashe MP, Brennan PA, Laprairie JL, Calamaras M, Nemeroff CB,

Ritchie JC, Cubells JF, Stowe ZN. (2011) Predictors of Neonatal Hypothalamic-Pituitary-Adrenal Axis Activity at Delivery. Clin Endocrinol (Oxf). Feb 1. 1365-2265.

111.Capello CF, Bourke CH, Ritchie JC, Stowe ZN, Newport DJ, Nemeroff A, Owens MJ (2011)

Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk. . J Pharmacol Exp Ther. Oct;339(1):275-85


112.Larsen HH, Ritchie JC, McNutt MD, Musselman DL (2011) Pulmonary embolism in a patient with

catatonia: an old disease, changing times. Psychosomatics. Jul-Aug;52(4):387-91.

113.Bruno D, Nierenberg JJ, Ritchie JC, Lutz MW, Pomara N (2012) Cerebrospinal fluid cortisol

concentrations in healthy elderly are affected by both APOE and TOMM40 variants. Psychoneuroendocrinology. Mar;37(3):366-71

114.Kalinina J, Peng J, Ritchie JC, Van Meir EG ,(2011) Proteomics of gliomas: initial biomarker

discovery and evolution of technology. . Neuro Oncol. Sep;13(9):926-42. Review. 115.Bruno D, Pomara N, Nierenberg J, Ritchie JC, Lutz MW, Zetterberg H, Blennow K. (2012) Levels

of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants. Exp Gerontol. May;47(5):347-52.

116.Eiland L, Oyesiku NM, Ritchie JC, Isaacs S, Ioachimescu AG (2012) Pathogenesis of marked

pituitary enlargement and increased serum thyroid-stimulating hormone in primary hypothyroidism. Thyroid. Jan;22(1):101-2.

117.Rovin ML, Boss-Williams KA, Alisch RS, Ritchie JC, Weinshenker D, West CH, Weiss JM. 9 (2012) Influence of chronic administration of antidepressant drugs on mRNA for galanin, galanin receptors, and tyrosine hydroxylase in catecholaminergic and serotonergic cell-body regions in rat brain. Neuropeptides. Apr;46(2):81-91.

118.Borgman MP, Hiemer MF, Molinelli AR, Ritchie JC, Jortani SA (2012) Improved sensitivity for methotrexate analysis using enzyme multiplied immunoassay technique on the Siemens Viva-E instrument. Ther Drug Monit. Apr;34(2):193-7.

119.Rhea JM, Snyder ML, Winkler AM, Abou-Diwan C, Fantz CR, Ritchie JC, Szlam F, Tanaka KA,

Molinaro RJ. (2012) Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples. J Chromatogr B Analyt Technol Biomed Life Sci. Apr 15;893-894:168-72.

120.Molinaro RJ, Winkler AM, Kraft CS, Fantz CR, Stowell SR, Ritchie JC, Koch DD, Heron S,

Liebzeit J, Santen SA, Guarner J, (2012) Teaching laboratory medicine to medical students, implementation and evaluation. Arch Pathol lab Med, 136:1423-28.

121Dunlop BW, Binder EB, Cubells JF, Goodman MM, Kelley ME, Kinkead B, Kutner M, Nemeroff

CB, Newport DJ, owens MJ, Pace TW, Ritchie JC, Rivera VA, Westen D, Craighead WE, Mayberg HS. ( 2012). Predictors of remission in depression to individual and combined treatments (PreDICT) study protocol for a randomized controlled trial, Trials, 13:1006, doi: 10.1186/1745-6215-13-06.

122.Molinaro RJ, Winkler AM, Kraft CS, Fantz CR, Stowell SR, Koch DD, Heron S, Lievzeit J, Santen

SA, Guarner J. (2012), Teaching laboratory medicine to medical students: implementation and evaluation. Arch Pathol Lab Med, 136(11), 1423 – 1429.

123.,Rye DB, Bliwise DL, Parker K, Trotti LM, Saini P, Farley J, Freeman A, Garcia PS, Owens MJ,

Ritchie JC, Jenkins A. (2012) Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Sci Transl Med, Nov21;4(161)161tra151.


124.Rhea JM, Ritchie JC, Molinaro RJ (2012) Development of a liquid chromatography tandem mass

spectrometry method for iothalamate measurement to assess renal function for potential kidney donation. (2013) Clin Chem Acta , 420:104 – 108.

125.Snyder ML, Wiley C, Molinaro RJ, Ritchie JC, Fantz RF. (2013) Falsely increased hCG in patients

with high leukocyte counts. Clin Chem, 59(7) 1127 – 1129. 126.Rhea JM, Koch D, Ritchie JC, Singh HV, Young AN, Burgess T, Molinaro RJ. (2013), Unintended

reporting of misleading Hb A1c values when using assays incapable of detecting hemoglobin variants. Arch Path and Lab Med, 137(12):1788-1791.

127. French D, Sujishi KK, Long-Boyle JR, Ritchie JC. (2014), Development and validation of a liquid

chromatography-tandem mass spectrometry assay to quantify plasma busulfan. Ther Drug Monit 36(2), 169-174.

128.Johnson EL, Stowe ZN, Ritchie JC, Newport DJ, Newman ML, Knight B, Pennell PB. (2014)

Carbamazepine clearance and seizure stability during pregnancy. Epilepsy Behav, 11:33C, 49-53. 129. Wang L, Evatt ML, Maldonado LG, Perry WR, Ritchie JC, Beecham GW, Martin ER, Haines JL,

Pericak-Vance MA, Vance JM, Scott WK (2014). Vitamin D from different sources is inversely associated with Parkinson disease. Mov Disord. 2014 Dec 27

130. Storrow AB, Nowak RM, Diercks DB, Singer AJ, Wu AH, Kulstad E, LoVecchio F, Fromm C,

Headden G, Potis T, Hogan CJ, Schrock JW, Zelinski DP, Greenberg MR, Christenson RH, Ritchie JC, Chamberlin JS, Bray KR, Rhodes DW, Trainor D, Southwick PC (2014). Absolute and relative changes (delta) in troponin I for early diagnosis of myocardial infarction: Results of a prospective multicenter trial., Clin Biochem. 2014 Sep 28.

131 .Storrow AB, Christenson RH, Nowak RM, Diercks DB, Singer AJ, Wu AH, Kulstad E, LoVecchio

F, Fromm C, Headden G, Potis T, Hogan CJ, Schrock JW, Zelinski DP, Greenberg MR, Ritchie JC, Chamberlin JS, Bray KR, Rhodes DW, Trainor D, Holmes D, Southwick PC. (2014) Diagnostic performance of cardiac Troponin I for early rule-in and rule-out of acute myocardial infarction: Results of a prospective multicenter trial. Clin Biochem. 2014 Sep 4.

132. Hill CE, Burd EM, Kraft CS, Ryan EL, Duncan A, Winkler AM, Cardella JC, Ritchie JC,

Parslow TG. (2014) Laboratory test support for ebola patients within a high-containment facility Lab Med. 2014 45(3)

133. Polepally AR, Pennell PB, Brundage RC, Stowe ZN, Newport DJ, Viguera AC, Ritchie JC,

Birnbaum AK. (2014) MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION. Ann Clin Transl Neurol. 2014 Feb;1(2):99-106.

134. Locus coeruleus neuronal activity determines proclivity to consume alcohol in a selectively-bred

line of rats that readily consumes alcohol. West CH, Boss-Williams KA, Ritchie JC, Weiss JM. Alcohol. 2015 Nov;49(7):691-705.

135. Comparison of FilmArray and Quantitative Real-Time Reverse Transcriptase PCR for Detection of Zaire Ebolavirus from Contrived and Clinical Specimens. Southern TR, Racsa LD, Albariño CG, Fey PD, Hinrichs SH, Murphy CN, Herrera VL, Sambol AR, Hill CE, Ryan EL, Kraft CS, Campbell S, Sealy TK, Schuh A, Ritchie JC, Lyon GM 3rd, Mehta AK, Varkey JB, Ribner BS, Brantly KP, Ströher U, Iwen PC, Burd EM. J Clin Microbiol. 2015 Sep;53(9):2956-60


136. Quantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in

Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS). Noguez JH, Ritchie JC. Methods Mol Biol. 2016;1383:21-7.

137. Comprehensive evaluation of thyrotropinomas: single-center 20-year experience. Azzalin A, Appin

CL, Schniederjan MJ, Constantin T, Ritchie JC, Veledar E, Oyesiku NM, Ioachimescu AG. Pituitary. 2016 Apr;19(2):183-93

138.Reprint of: Locus coeruleus neuronal activity determines proclivity to consume alcohol in a selectively-bred line of rats that readily consumes alcohol. West CH, Boss-Williams KA, Ritchie JC, Weiss JM. Alcohol. 2016 Feb;50:91-105

139. Time-dependent effects of dexamethasone plasma concentrations on glucocorticoid receptor

challenge tests. Menke A, Arloth J, Best J, Namendorf C, Gerlach T, Czamara D, Lucae S, Dunlop BW, Crowe TM, Garlow SJ, Nemeroff CB, Ritchie JC, Craighead WE, Mayberg HS, Rex-Haffner M, Binder EB, Uhr M. Psychoneuroendocrinology. 2016 Jul;69:161-71.

140.DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient. Wang L, Maldonado L, Beecham GW, Martin ER, Evatt ML, Ritchie JC, Haines JL, Zabetian CP, Payami H, Pericak-Vance MA, Vance JM, Scott WK. Neurol Genet. 2016 Apr 12;2(3):e72

141.Anabasine Is a Poor Marker for Determining Smoking Status of Transplant Patients. Feldhammer M, Ritchie JC. Clin Chem. 2016 Dec 16. pii: clinchem.2016.265546.

b. MANUSCRIPTS IN PRESS:

c. MANUSCRIPTS SUBMITTED

d. BOOK CHAPTERS:

1. Krishnan, K.R.R., Nemeroff, C.B., Manepalli, A.N., France, R.D., Ritchie, J.C., Carroll, B.J. (1986). Physiology of Human HPA regulation in depression. In: Biological Psychiatry, (Shagass C., et al, Eds.), Elsevier, New York, 808-810.

2. Kilts, C.D., Johnson, K.L., Ritchie, J.C. (1987). Analytical and methodological considerations in

the study of the HPA Axis. In: The Hypothalamic-Pituitary-Adrenal Axis, (Schatzberg, A.F. and Nemeroff, C.B., Eds.), Raven Press, New York, 37-53.

3. Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., Venkataranman, S., France, R.D., Nemeroff,

C.B., Carroll, B.J. (1988). What is the relationship between plasma ACTH and plasma cortisol in normal humans and depresssed patients? In: The Hypothalamic-Pituitary-Adrenal Axis, (Schatzberg, A.F. and Nemeroff, C.B., Eds.), Raven Press, New York, 115-132.

4. Ritchie, J.C., Nemeroff, C.B. (1991). The hypothalamic-pituitary-adrenal axis and depression. In:

Stress, Neuropeptides, and Systemic Disease, (McCubbin, J.A., Kaufmann, P.G., and Nemeroff, C.B., Eds.), Academic Press, Orlando, Florida, 181-197.


5. Krishnan, K.R.R., Doraiswamy, P.M., Venkataraman, S., Reed, D., Ritchie, J.C. (1991). Current

concepts in hypotalamo-pituitary-adrenal axis regulation. In: Stress, Neuropeptides, and Systemic Disease, (McCubbin, J.A., Kaufmann, P.G., and Nemeroff, C.B., Eds.), Academic Press, Orlando, Florida, 19-35.

6. Ritchie, J.C., Bissette, G. (1992). Radioimmunoassay methods. In: Neuroendocrinology,

(Nemeroff, C.B., Ed), CRC Press, Boca Raton, Florida, 39-50. 7. Owens, M.J., and Ritchie, J.C. (1999). Clinical Neurochemistry. In: The Neurobiological

Foundation of Mental Illness, (Charney, D.S., Nestler, E.J., Bunney, B.S., Eds.), Oxford University Press, New York , NY.

8 Hammett-Stabler CA, Geis DC, Ritchie JC, Papadea C. (2010). Monitoring of mycophenolate

acid in serum or plasma using LC tandem mass spectroscopy. In Methods in Molecular Biology 603:379-387.

9. Molinaro RJ and Ritchie JC (2010). Quantitation of iothalamate in urine and plasma using liquid

chromatography electrospray tandem mass spectrometry (HPLC-ESI-MS/MS). In Methods in Molecular Biology 603:307-315.

10 Snyder ML and Ritchie JC (2010). Quantification of busulfan in plasma using liquid

chromatography electrospray tandem mass spectrometry (HPLC-ESI-MS/MS). In Methods in Molecular Biology 603:129-136.

e. SELECTED ABSTRACTS:

1. Castor, C.W., Wright, D., Ritchie, J.C. (1969). Connective tissue regulation. J. Lab and Clin. Med.

Abstract, 74:860. 2. Castor, C.W., Scott, M.E., Ritchie, J.C. (1971). Pharmacologic regulation of mitogenesis induced

by a platelet mediator. XIV International Congress of Rheumatology. 3. Ritchie, J.C., Keglemeyer, A.E., Walker, J.T. (1985). Performance of two non-extracted

radioimmunoassays for plasma ACTH compared with two reference laboratory assays. Society for Neuroscience Abstracts, 11(1): 545, l5th Annual Meeting, Dallas, Texas.

4. Krishnan, K.R.R., Carroll, B.J., Manepalli, A.N., France, R.D., Ritchie, J.C., Nemeroff, C.B.

(1985). Physiology of human HPA regulation, IV World Congress of Biological Psychiatry. 5. Krishnan, K.R.R., Ritchie, J.C., Manepalli, A.N., et al. (1985). What is the relationship between

ACTH and cortisol in normal and depressed patients. American College of Neuropsychopharmacology Annual Meeting.

6. Shun-Wei, Li, Ritchie, J.C., Carroll, B.J. (1986). Plasma corticosterone and dexamethasone

suppression test normalization. Society of Biological Psychiatry, 41st Annual Meeting, Washington, D.C.

7. Ritchie, J.C., Manepalli, A.N., France, R.D., Nemeroff, C.B., Carroll, B.J. (1986). What is the

relationship between ACTH and cortisol dissociation in depression. American Psychiatric Association Annual Meeting, Washington, D.C.

8. Manepalli, A.N., Ritchie, J.C., Rayasam, K., et al. (1986). GRH stimulation test in depression.

American Psychiatric Association Annual Meeting, Washington, D.C.


9. Belkin, B.M., Ritchie, J.C., Rayasam, K., et al. (1986). Plasma dexamethasone concentrations and

the dexamethasone suppression test. Society for Neuroscience Abstracts, 12(1):606, 16th Annual Meeting, Washington, D.C.

10. Ritchie, J.C., Owens, M.J., O'Connor, L.W., et al. (1986). Measurement of ACTH and CRF

immunoreactivity in adrenal gland and lymphocytes. Society for Neuroscience Abstracts, 12(2): 1041, 16th Annual Meeting, Washington, D.C.

11. Nemeroff, C.B., Krishnan, K.R.R., Owens, M.J., Bissette, G., Manepalli, A.N., Ritchie, J.C., et al.

(1986). Growth hormone releasing factor: Endocrine and cerebrospinal fluid studies. Society for Neuroscience Abstracts, 12(1): 566, 16th Annual Meeting, Washington, D.C.

12. Chappell, P.B., Smith, M.A., Ritchie, J.C., et al. (1986). Effects of corticotropin-releasing factor

on plasma ACTH and cortisol concentrations in schizophrenia. Society for Neuroscience Abstracts, 12(2): 1441, 16th Annual Meeting, Washington, D.C.

13. Ritchie, J.C., Kegelmeyer, A.E., Walker, J.T., et al. (1987). Comparison of plasma cortisol

determinations by the Abbott TDx and C.P.B. methodology, for use in the dexamethasone suppression test (DST). Clin. Chem., 33(6):959, American Association for Clinical Chemistry, 40th Annual Meeting, San Francisco, California, 1987.

14. Ritchie, J.C., O'Ouinn, A.N., Hodges, K.V., et al. (1987). Plasma dexamethasone concentrations

in children and adolescents during the dexamethasone suppression test (DST). Society of Biological Psychiatry, 42nd Annual Meeting, Chicago, Illinois.

15. Ellinwood, E.H., Nishita, J.K., Kuhn, C.M., Ritchie, J.C., et al. (1987). Cocaine effects on plasma

vasopressin, corticosterone and prolactin in the rat: Time course following acute injection. Society for Neuroscience Abstracts, 13(1):85, 17th Annual Meeting, New Orleans, Louisiana.

16. Johnson, K.L., Anderson, C.M., Nishita, J.K., Ritchie, J.C., et al. (1987). The distribution and

dynamics of epinephrine-containing neurons in the rat brain: Influence of adrenocortical state. Society for Neuroscience Abstracts, 13(1):478, 17th Annual Meeting, New Orleans, Louisiana.

17. Lee, J., Mitsushio, H., Paris, J.M., Lorens, S.A., Ritchie, J.C., et al. (1987). Differential behavioral

and endocrine effects produced by intra-raphe administration of the neurokinin agonist DiMe C7, and the GABA agonist, Muscimol. Society for Neuroscience Abstracts, 13(1):613, 17th Annual Meeting, New Orleans, Louisiana.

18. Ritchie, J.C., Liu, P.K., Nemeroff, C.B., et al. (1987). Simultaneous determination of CRF and

ACTH release from hypothalamic-pituitary blocks perfused in vitro: Responses to physiological and pharmacological manipulation. Society for Neuroscience Abstracts, 13(2):1371, 17th Annual Meeting, New Orleans, Louisiana.

19. Nishita, J.K., Ellinwood, E.H., Rockwell, W.J.K., Ritchie, J.C., et al. (1988). A new chronic

starvation paradigm in the developing female rate: Implications for the study of anorexia nervosa. 43rd Annual Meeting Society of Biological Psychiatry, Montreal, Ouebec, Canada.

20. Davis, M.D., Nemeroff, C.B., Ritchie, J.C. (1988). Dynamics of concomitant CRF, AVP and

ACTH secretion from perfused hypothalamic-hypophyseal explants in vitro after electrical stimulation and drug infusion. Annual Meeting of the Endocrine Society.

21. Nishita, J.K., Ellinwood, E.H., Rockwell, W.J.K., Ritchie, J.C., et al. (1988). Stress-related effects

of long-term caloric restriction on plasma corticosterone and vasopressin in the female rat: A new methodological apparatus. Society for Neuroscience Abstracts 14(1):444, 18th Annual Meeting, Toronto, Ontario, Canada.


22. Ritchie, J.C., Liu, P.K., Bissette, G., et al. (1988). A practical radioimmunoassay for plasma

corticotropin-releasing factor. Society for Neuroscience Abstracts, 14(2): 1286, 18th Annual Meeting, Toronto, Ontario, Canada.

23. Ritchie, J.C., Scotch, R.L., Walker, J.T., et al. (1989). Human growth hormone response to ovine

corticotropin-releasing factor. Society for Neuroscience Abstracts, 15(2):1373, l9th Annual Meeting, Phoenix, Arizona.

24. Reed, D., Ritchie, J.C., Carroll, B.C., et al. (1990). Implications of simultaneous monitoring of

plasma dexamethasone levels for the DST. Neuroendocrinology Letters, 12(4):261; XXI Congress of the International Society of Psychoneuroendocrinology, Buffalo/Niagara Falls, New York.

25. Vargas, M.A., Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1990). Time-course of action of the

triazolobenzodiazepine, alprazolam, on HPA axis function in rats. Society for Neuroscience Abstracts, 16(1):92, 20th Annual Meeting, St. Louis, Missouri.

26. Clerpial, M.A., Grobin, A.C., Hargrove, E.F., McLean, K.P., Ritchie, J.C., et al. (1990). Elevated

dorsal noradrenergic bundle turnover and plasma corticosterone responses to stress in rats selectively bred for high swim test activity. Society for Neuroscience Abstracts, 16(1): 165, 20th Annual Meeting, St. Louis, Missouri.

27. Owens, M.J., Ritchie, J.C., Nemeroff, C.B. (1991). THDOC decreases plasma corticosterone

concentrations via a non-glucocorticoid mechanism. Society for Neuroscience Abstracts, 17(2):1343, 21st Annual Meeting, New Orleans, Louisiana.

28. Ritchie, J.C., Owens, M.J., Nemeroff, C.B. (1991). Corticotropin releasing factor metabolism in

the rat hypothalamus. Society for Neuroscience Abstracts, 17(1): 404, 21st Annual Meeting, New Orleans, Louisiana.

29. Ritchie, J.C., Gupta, S.K., Carroll, B.J., Krishnan, K.R.R. (1991). Towards a pharmacokinetic

pharmacodynamic model of plasma dexamethasone concentration during the DST. Biological Psychiatry, 29(suppl): 725S.

30. Ritchie, J.C., Bragg, D.C., White, N.R., Krishnan, K.R.R., Carroll, B.J. (1991). Plasma

vasopressin, cortisol, and ACTH baseline levels in depression. Neuroendocrinology Letters, 13:208.

31. Hayden-Hixson, D.M., White, N., Ritchie, J.C., Nemeroff, C.B. (1992). Neonatal handling:

Effects on spatial memory, basal corticosterone levels, and hippocampal function. Society Neuroscience Abstracts, 18(2):1426, 22nd Annual Meeting, Annaheim, California.

32. Bragg, C., Ritchie, J.C., Carroll, B.J., Breitner, J.C.S. (1992). A matched twin study of DHEA and

DHEA-S in alzheimer's disease. Biological Psychiarty, 31:201A. 33. Akers, L.C., Ritchie, J.C., Orsulak, P.J. (1993). Determination of salivary cortisol using a

modification of the Abbott TDx serum cortisol assay. Clin Chem, 6:1255. 34. Ritchie, J.C., Nemeroff, C.B. (1993). Corticotropin releasing factor degradation by purified

peptidases. Society of Neuroscience Abstracts, 19(2):1363, 23rd Annual Meeting, Washington, D.C.

35. Ritchie, J.C., Sundar, K.S., Nemeroff, C.B. (1994). Effect of specific peptidase inhibitors on CRF

induced ACTH release in cultured rat pituitary cells. Society of Neuroscience Abstracts, 20(1), 447, 24th Annual Meeting, Miami Beach, FL.


36. Kim, D.K., Kim, B.L., Yu, B.H., Hong, K.S., Ritchie, J.C., Austin, S., Carroll, B.J. (1995). Rate-

sensitive glucocorticoid feedback inhibition in normal humans and depressed patients. Society for Neuroscience Abstracts, 21(2): 873, 25th Annual Meeting, San Diego, CA.

37. Ritchie, J.C., Nemeroff, C.B. (1995). Effect of three ectopeptidases on corticotropin-releasing

factor: Metabolism and functional aspects. Society for Neuroscience Abstracts, 21(1): 761, 25th Annual Meeting, San Diego, CA.

38. Ritchie, J.C., Zhang, W. (1996). Modification of the BioRad antidepressant methodology to

measure the serotonin reuptake inhibitors. Clin Chem, 42(6): S222, 48th Annual Meeting, Chicago, IL.

39. Ritchie, J.C., Tuten, T., Jerkunica, I., Zhang, H., Mullins, R.E. (1997). Evaluation of the Cobas-

Integra for drugs of abuse testing. Clin Chem, 43(6): S217. 40. Mullins, R.E., Jerkunica, I., Ritchie, J.C., Tuten, T. (1997). HbA1c measurements by

immunoassay on the Cobas-Integra. Clin Chem, 43(6): S154. 41. Ritchie, J.C., Tuten, T., Jerkunica, I., Zhang, H., Sgoutas, D.S., Mullins, R.E. (1998). Evaluation

of the Cobas-Integra for routine lipid testing. Clin Chem, 44(6): A78. 42. Ritchie, J.C., Mullins, R.E., Tuten, T., Zhang, H., Jerkunica, I. (1998). Evaluation of the DAU

lysergic acid diethylamide (LSD) assay on the Cobas-Integra. Clin Chem, 44(6): A86. 43. Ritchie, J.C., Slotkin, T.A., Seidler, F.J. (1998). Effects of aging and glucocorticoid treatment on

monoamine oxidase subtypes in rat cerebral cortex: Therapeutic Implications. Society for Neuroscience Abstracts, 24, 28th Annual Meeting, Los Angeles, CA.

44. Ritchie, J.C., Mullins, R.E.; Benson, E, Davis, T. (2001) Comparison of Five Assays for

Homocysteine. American Association for Clinical Chemistry Annual Meeting, Chicago, IL. 45. Ritchie, J.C. and Ramsey, C. (2001) Pretreatment with High Dose CRF Increases Subsequent CRF

Catabolism in Rat Pituitary Cultures. Society for Neuroscience Annual Meeting SanDiego, CA. 46. Ritchie, J.C., Whooley, M.A., Mullins, R.E. (2002) Evaluation of Two Extended Range CRP

Assays. 18th International Congress of Clinical Chemistry, Kyoto, Japan.

47. Hillyer, K.L., Rapaport, H.J. Roback, J.D., Ritchie, J.C., Hillyer, C.D. (2002) Pre-filtration Oxygenation Abrogates the Leukoreduction Filtration Lesion in Hemoglobin AS Whole Blood Units. American Society of Hematology Annual Meeting, Philadelphia, PA.

48. Nolan, J.L., Mendrinos, S., Skountzou, I., Ritchie, J.C., Lewis, M.M., (2003) analysis and

classification of proteomic profiles in breast cancervia a combined cytology/SELDI-TOF technique. American Association for Clinical Chemistry Annual Meeting, Philadelphia, PA.

49. Henry, A, Stowe, Z.N., Newport, D.J., Penell, P., Glover, B., Ritchie, J.C., Donovan, J.,

DeVane, C.L. (2006) Pharmacogenetic (PG) Modulators of Fetal Exposure to Medicine. American Psychiatric Association Annual Meeting, Toronto, Canada

50. Ritchie, J.C., Berry, D., Dugaw, K., McMillin, G., Wilson, J. (2006) Inter-laboratory

Comparison of Serum Lamotrigine Methods. Clin Chem 52:A108 AACC Annual Meeting, Chicago, IL.


51. Sanii, L.S., Ritchie, J.C., Koch, D.D. (2006) Analytical Interference from Lymphazurin (isosulfan

blue) Lymphatic Dye on Common Clinical Chemistry Analytes. Clin Chem., 52:A69 AACC Annual Meeting, Chicago, IL.

52. Kossover, C., Ritchie, J.C., Fantz, C.R. (2006) Effect of Hemolysis on Samples Submitted for

Coagulation Studies. Clin chem., 52:A23, AACC Annual Meeting, Chicago, IL 53. Sanii, LS, Hunter, S, Schmotzer, B, Jolly, A, Ritchie, JC (2007) Intracellular protein expression

patterns of glioblastomas, meningiomas, and metastatic brain tumors using surface-enhanced laser desorption mass spectroscopy (SELDI-TOF-MS) Clin Chem 53(S6), A105 AACC Annual Meeting, San Diego, CA

54. Molinaro, RJ, Ritchie, JC (2007) Identification and quantitation of iothalamate to assess renal

function using liquid chromatography-tandem mass spectrometry. Clin Chem 53(S6), A92 AACC Annual Meeting, San Diego, CA

55. Molinaro, RJ, Atha, B, Ritchie, JC, Koch, DD (2007) Three-way comparison and validation study

of a newly available intact parathyroid hormone assay. Clin Chem 53(S6), A198 AACC Annual Meeting, San Diego, CA

56. Ritchie, JC, Glover, B, Ramsey, C, Scott-Harrell (2009) A Routine UPLC-MS/MS Assay for the

Newer Antidepressants. Therapeutic Drug Monitoring, 31:646. 57. Ritchie, JC, Glover, B, Ramsey, C, Scott-Harrell (2009) A Routine UPLC-MS/MS Assay for the

Newer Antipsychotics. Therapeutic Drug Monitoring, 31:646.

CURRICULUM VlTAE - Atlanta, GA - Emory Healthcare...James C. Ritchie, Ph.D. Page 6 CLH Committees...

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