Curriculum vitae George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO

Assistant Professor of Internal Medicine

School of Medicine, University of Thessaly

Larissa, Greece

Co-chair, Guidelines Committee of the European Stroke Organization

Secretary General, Hellenic Stroke Organization

Larissa, February 23, 2016

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List of contents

List of contents .................................................................................................................................................................... 2

CURRICULUM VITAE ...................................................................................................................................................... 3 Short curriculum vitae ....................................................................................................................................................................... 4 Personal Information ......................................................................................................................................................................... 5 Academic posts ................................................................................................................................................................................... 5 Academic degrees .............................................................................................................................................................................. 5 Grants - Scholarships - Awards ........................................................................................................................................................ 5 Posts abroad ........................................................................................................................................................................................ 5 Clinical certifications .......................................................................................................................................................................... 5 Research ............................................................................................................................................................................................... 6 Invited lectures abroad (list of invited lectures in Greece is also available upon request) ....................................................... 6 Membership in scientific associations ............................................................................................................................................. 6

SELECTED LITERATURE ................................................................................................................................................. 7 Original articles .................................................................................................................................................................................. 8 Review articles .................................................................................................................................................................................. 12 Meta-analyses ................................................................................................................................................................................... 13

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CURRICULUM VITAE

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Short curriculum vitae

George Ntaios serves as an Assistant Professor of Internal Medicine in the University of Thessaly. He is a board-

certified Internist with academic training and certification in Stroke Medicine, and practices in the Department of

Medicine in Larissa University Hospital.

After graduating from the Medical Faculty of Charles University in 2000, he continued his postgraduate studies in

Thessaloniki where he completed his MSc and PhD courses in 2003 and 2008 respectively in the Aristoteles

University of Thessaloniki. In 2011, he completed successfully the European Master in Stroke Medicine in Danube

University (Krems, Austria) supported by scholarships from the European Stroke Organization (ESO) and the

Hellenic Society of Atherosclerosis. He attended the ESO Stroke Summer Schools in Barcelona (2007) and Lausanne

(2008). He worked for one year as a stroke research fellow in the Acute Stroke Unit of the Lausanne University

Hospital.

He co-chairs the ESO Guidelines Committee since May 2014 and was the leading author of the Standard Operating

Procedure for the development of the ESO Guidelines. Also, he chaired the working group which developed the ESO

guidelines for the temperature management in acute ischaemic stroke. He is a member of the Editorial Board of the

Virtual Stroke University and the Scientific Committee of the European Stroke Organization Conference (ESOC).

His main research interest focuses on secondary stroke prevention and stroke prognosis. He participates in

observational studies and randomized controlled trials of acute stroke management and stroke prevention as

National Co-ordinator or Principal Investigator.

He is author of >100 articles in peer-reviewed journals, invited speaker in >60 international and local conferences,

and invited reviewer in >60 journals.

He is blessed with a wonderful wife and three lovely children. He enjoys spending his time with family at home.

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Personal Information

Name/Surname Georgios Ntaios Birth date November 6th, 1975 Citizenship Greek Status Married, 2 children Professional address Department of Medicine, Larissa University Hospital,

Biopolis 41110, Larissa, Greece Contact details T: +30 241 3502888

M: +30 697 2770288 F: +30 241 3501557 E-mail: gntaios@med.uth.gr

Research focus Primary and secondary stroke prevention; Acute stroke treatment; Stroke prognosis

Academic posts

2014 - current Assistant Professor of Internal Medicine 2011-2014 Lecturer of Internal Medicine

Academic degrees

2011 MSc (Stroke Medicine), Danube University, Austria 2008 PhD, University of Thessaloniki, Greece 2003 MSc, University of Thessaloniki, Greece 2000 MD, Charles University, Czech republic

Grants - Scholarships - Awards

2015-2020 PRECIOUS: PREvention of Compliations to Improve Outcome in elderly patients with acute Stroke. Funded with 6,000,000€ by the European Union/Horizons 2020 (http://www.precious-trial.eu)

09/02/2012 Best poster presentation: “Derivation and double external validation of an integer-based prognostic score (ASTRAL score) to predict functional outcome in acute ischemic stroke: a collaborative analysis of the ASTRAL, Athens and Vienna stroke registries”, Swiss Stroke Trialists Meeting, Zurich, Switzerland

2009 Scholarship, European Stroke Organisation

2009 Scholarship, Hellenic Society of Atherosclerosis

Posts abroad

2009 - 2011 MSc (Stroke Medicine), Danube University, Austria August-October 2011 Stroke Unit, St. George’s Hospital, London, UK July - December 2010 Stroke Unit, CHUV, Lausanne, Switzerland January-June 2009 Stroke Unit, CHUV, Lausanne, Switzerland

Clinical certifications

2014 Good Clinical Practice (GCP) certification 2009 National Institute of Health Stroke Scale (NIHSS) training certification, National Stroke Organization 2009 Modified Rankin Scale training certification, University of Glasgow

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2008 Urgent prehospital care, Ministry of Health, Greece 2007 Advanced Pediatric Life Support APLS, Advanced Life Support Group, UK 2007 Advanced Life Support (ALS) Provider, European Resuscitation Council

Research

2015 NAVIGATE-ESUS, https://clinicaltrials.gov/ct2/show/NCT02313909 (National Coordinator) 2015 PRECIOUS, http://www.precious-trial.eu, (National Coordinator) 2014 BIOSIGNAL, www.p3.snf.ch/Project-142422 (Principal investigator) 2014 SORCAN (Stroke Outcome Research Canada), www.sorcan.ca (International collaborator) 2014 EBBINGHAUS, www.clinicaltrials.gov/show/NCT02207634, (Principal investigator) 2014 GLORIA-AF, www.clinicaltrials.gov/show/NCT01468701 (Principal investigator) 2013 LASTRO (Larissa Stroke Outcome Registry), (Chief Investigator) 2013 PREVISE, www.clinicaltrials.gov/ct2/show/NCT01915862 (Sub-investigator) 2013 FOURIER, www.clinicaltrials.gov/ct2/show/NCT01764633, (Principal investigator) 2011 ENOS, www.clinicaltrials.gov/ct2/show/NCT00989716, (National Co-ordinator for Greece)

Invited lectures abroad (list of invited lectures in Greece is also available upon request)

05/02/2016 “Stroke prevention in non-valvular atrial fibrillation”. 10th Portuguese Stroke Conference. Porto, Portugal

11/12/2015 “Stroke in the era of NOACs”, MIDI anticoagulation Academy: “Innovations in anticoagulation: Challenges in emergency and individual patient management”, Oslo, Norway

21/11/2015 GRADE methodology. 3rd ESO GRADE workshop, Garmisch-Partenkirchen, Germany 16/10/2015 "Embolic Strokes of Undetermined Source: not so cryptogenic any more?”, European PFO

summit, Zurich, Switzerland 10/09/2015 "Embolic Strokes of Undetermined Source: not so cryptogenic any more?”, XV Congresso

Nazionale della Società Italiana per lo Studio dello Stroke & 10th Regional Meeting of the Meditarranean Stroke Society, Ragusa, Italy

18/04/2015 “Monitoring: what, when and how long?”, 1st European Stroke Organisation Conference, Glasgow, UK

17/04/2015 “Prime time for acute prevention with double anti-agreggation – moderator”, 1st European Stroke Organisation Conference, Glasgow, UK

12/01/2015 GRADE methodology. ESO GRADE workshop, Frankfurt, Germany 18/11/2014 “Summary and Next steps? Targets for 2016 - where do we need to update guidelines?”, ESO

Karolinska Stroke Update, Stockholm, Sweden 18/11/2014 “ESO Guidelines: temperature management in acute ischaemic stroke”, ESO Karolinska Stroke

Update, Stockholm, Sweden 08/05/2014 “ESO Guidelines: temperature management in acute ischaemic stroke”, European Stroke

Conference, Nice, France 08/05/2014 “ A short introduction on GRADE”, European Stroke Conference, Nice, France 23/11/2013 “New oral anticoagulants: are we ready for wide use after stroke: yes”, 2013 Joint Meeting of te

Belgian Neurological Society and the Belgian Stroke Council – Controversies in Stroke, Leuven, Belgium

06/09/2012 “Cerebrovascular prevention in cardiac failure”, State of the Art, CHUV, Lausanne, Switzerland 29/09/2012 “The ASTRAL score to predict outcome in acute ischemic stroke”, XII Congresso Nazionale Della

Societa’ Italiana Per Lo Studio Dello Stroke. “Ictus: Quale futuro?” L” Aquila, Italy

Membership in scientific associations

2013 - Institute For The Study And Education On Thrombosis And Antithrombotic Therapy 2011 - Hellenic Cardiovascular Research Society

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2009 - Fellow of the European Stroke Organisation (FESO) - Co-chair of the ESO Guidelines Committee (2014-present) - Member of the ESO Education Committee (2012-2013) - Member of the της ESO Stroke Registry Task Force (2013) - Chair of the working group for the ESO guidelines on “Temperature management in acute

ischemic stroke” (2013)

SELECTED LITERATURE

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Original articles

Effect of hyperacute (within 6 hours) transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke Lisa Woodhouse, Polly Scutt, Kailash Krishnan, Eivind Berge, John Gommans, George Ntaios, Joanna Wardlaw, Nikola Sprigg, Philip M Bath Stroke 2015, online early External validation of the ISAN score for predicting stroke-associated pneumonia in the Athens Stroke Registry Vasileios Papavasileiou, Haralampos Milionis, Craig J. Smith, Konstantinos Makaritsis, Benjamin D. Bray, Patrik Michel, Jane Molloy, Efstathios Manios, Konstantinos Vemmos, George Ntaios

Journal of Stroke and Cerebrovascular Diseases 2015, online early

Embolic strokes of undetermined source in the Athens Stroke Registry: an outcome analysis George Ntaios, Vasileios Papavasileiou, Haralampos Milionis, Konstantinos Makaritsis, Anastasia Vemmou, Eleni Koroboki, Efstathios Manios, Konstantinos Spengos, Patrik Michel, Konstantinos Vemmos

Stroke 2015, online early

The European Stroke Organisation Guidelines: a standard operating procedure George Ntaios, Natan M. Bornstein, Valeria Caso, Hanne Christensen, Jacques De Keyser, Hans-Christoph Diener, Exuperio Diez-Tejedor, Jose M. Ferro, Gary A. Ford, Armin Grau1, Emanuella Keller, Didier Leys, David Russell, Danilo Toni, Guillaume Turc, Bart Van der Worp, Nils Wahlgren, Thorsten Steiner, for the European Stroke Organisation

International Journal of Stroke, 2015, online early

European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischaemic stroke G. Ntaios, T. Dziedzic, P. Michel, V. Papavasileiou, J. Petersson, D. Staykov, B. Thomas, T. Steiner, for the European Stroke Organisation

International Journal of Stroke, 2015, online early

Improving the Prediction of Spontaneous and post-thrombolytic Recanalisation in Ischemic Stroke patients P. Vanacker, D. Lambrou, A. Eskandari, M. Cordier, G. Ntaios, P. Maeder, R. Meuli, P. Michel Journal of Stroke and Cerebrovascular Diseases 2015, online early

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The ENOS Trial Investigators Lancet 2015; 385:617-28

Leukoaraiosis and recurrent stroke risk in patients with and without atrial fibrillation: the Athens Stroke Registry George Ntaios, Gregory Lip, Dimitris Lambrou, Vasileios Papavasileiou, Efstathios Manios, Haralampos J. Milionis, Konstantinos Spengos, Konstantinos P. Makaritsis, and Kostas N Vemmos Neurology 2015, online early

ASTRAL-R score Predicts absence of Recanalization after Intravenous Thrombolysis in Acute Ischemic Stroke

Peter Vanacker, Dimitris Lambrou, Mirjam Heldner, David Seiffge, Hubertus Mueller, Ashraf Eskandari, George Ntaios,

Pascal J Mosimann, Roman Sztajzel, Vitor Mendes Pereira, Patrick Cras, Stefan Engelter, Philippe Lyrer, Urs Fischer, Marcel Arnold, and Patrik Michel

Thrombosis and haemostasis 2015, online early

Embolic strokes of undetermined source (ESUS) in the Athens Stroke Registry: a descriptive analysis G. Ntaios, V. Papavasileiou, H. Milionis, K. Makaritsis, E. Manios, K. Spengos, P. Michel, K. Vemmos

Stroke 2015;46:176-181

Statin treatment is associated with improved prognosis in patients with AF-related stroke G. Ntaios, V. Papavasileiou, K. Makaritsis, H. Milionis, E. Manios, P. Michel, G.Y.H. Lip, K. Vemmos International Journal of Cardiology 2014; 177:129-33

Anaemia on admission predicts short and long-term outcome in patients with acute ischaemic stroke

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H. Milionis, V. Papavasileiou, A. Eskandari, S. D’Ambrogio-Remillard, G. Ntaios, P. Michel International Journal of Stroke 2014, online early

Poor stroke risk perception despite moderate public stroke awareness: insight from a cross-sectional national survey in Greece G. Ntaios, V. Melikoki,, G. Perifanos, K. Perlepe, F. Gioulekas, A. Karagiannaki, I. Tsantzali, C. Lazarou, N. Beradze, E. Poulianiti, M. Poulikakou, F. Palantzas, S. Kaditi, F. Perlepe, G. Sidiropoulos, K. Papageorgiou, V. Papavasileiou, K. Vemmos, K. Makaritsis, G.N. Dalekos Journal of Stroke and Cerebrovascular Diseases 2014, online early

Baseline characteristics of the 4011 patients recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial The ENOS investigators International Journal of Stroke 2014, online early Acute imaging does not improve ASTRAL score’s accuracy despite having a prognostic value G. Ntaios, V. Papavasileiou, M. Faouzi, P. Vanacker, M. Wintermark, P. Michel International Journal of Stroke 2014, in press Improving Prediction of Recanalization in Acute Large Vessel Occlusive Stroke P. Vanacker, D. Lambrou, A. Eskandari, P. Maeder, R. Meuli, G. Ntaios, P. Michel Journal of Thrombosis and Haemostasis 2014, in press Association of ischemic stroke subtype with long-term cardiovascular events G. Ntaios, V. Papavasileiou, K. Makaritsis, H. Milionis, M. Patrik, K. Vemmos European Journal of Neurology 2014, in press

Early major worsening in ischemic stroke: predictors and outcome G. Ntaios, D. Lambrou, D. Cuendet, P. Michel NeuroCritical Care 2013, in press Low ankle-brachial index predicts 5-year mortality but not recurrent stroke in patients with acute first-ever ischemic stroke H. Milionis, A. Vemmou, G. Ntaios, K. Makaritsis, E. Koroboki, V. Papavasileiou, P. Savvari, K. Spengos, K. Vemmos European Journal of Neurology 2013, in press

The ASTRAL score predicts 5-year dependence and mortality in acute ischemic stroke V. Papavasileiou, H. Milionis, P. Michel, K. Makaritsis, A. Vemmou, E. Koroboki, E. Manios, K. Vemmos, G. Ntaios Stroke 2013;44:1616-1620

External validation of ASTRAL score to predict 3- and 12-month functional outcome in the China National Stroke Registry G. Liu, G. Ntaios, H. Zheng, Y. Wang, P. Michel, D. Zheng Wang, J. Fang, V. Papavasileiou, L. Liu, K. Dong, C. Wang, X. Zhao, Y. Wang Stroke 2013; 44:1443-5

Aseptic meningoencephalitis mimicking transient ischaemic attacks V. Papavasileiou, H. Milionis, M. Cordier, A. Eskandari, G. Ntaios, P. Michel Infection 2013; 41:485-91

CHADS2, CHA2DS2-VASc and long-term stroke outcome in patients without atrial fibrillation G. Ntaios, G.Y.H. Lip, K. Makaritsis, V. Papavasileiou, H. Milionis, A. Vemmou, E. Koroboki, P. Savvari, E. Manios, H. Milionis, K. Vemmos Neurology 2013; 80:1009-17 Blood pressure changes in the acute ischemic stroke and outcome with respect to stroke etiology G. Ntaios, D. Lambrou, P. Michel Neurology 2012; 79:1440 - 1448 The type of atrial fibrillation is associated with long- term outcome in patients with acute ischemic stroke

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G. Ntaios, A. Vemmou, E. Koroboki, P. Savvari, K. Makaritsis, M. Saliaris, G. Andrikopoulos, K. Vemmos International Journal of Cardiology, 2013; 167:1519-23 An integer-based score to predict functional outcome in acute ischemic stroke: the ASTRAL score G Ntaios, M Faouzi, J Ferrari, W Lang, K Vemmos, P Michel Neurology 2012; 78:1916-22 Stroke etiology and predictors of outcome in patients with heart failure and acute stroke: a 10-year follow-up study Vemmos K, Ntaios G, Savvari P, Vemmou AM , Koroboki E, Manios E, Kounali A, Lip GYH European Journal of Heart Failure 2012; 14:211-8 Prevalence of atrial fibrillation in a Greek rural Population: the Arcadia Rural Study in Atrial Fibrillation Ntaios G, Synetou M, Saliaris M, Xynos K, Pappa D, Savvari P, Spengos K, Vemmos K Acta Cardiologica 2012; 67:65-9 An intravenous insulin protocol for strict glycemic control in acute ischaemic stroke G. Ntaios, M. Egli, A. Arsovka, D. Joye, Y. Bettex, E. Lauber, A. Eskandari, S. D’Ambrogio, B. Richoz, J. Ruiz, P. Michel, European Journal in Neurology 2012; 19:443-51 The effect of thrombolysis on short-term improvement depends on initial stroke severity G. Ntaios, M. Faouzi, P. Michel Journal of Neurology 2012;259(3):524-9 Persistent hyperglycemia at 24-48 hours in acutely hyperglycemic stroke patients is not associated with worse functional outcome G. Ntaios, C. Abatzi, M. Alexandrou, D. Lambrou , S. Chatzopoulos, M. Egli, J. Ruiz , N. Bornstein , P. Michel Cerebrovascular Diseases 2011; 32:561-6 Perfusion-CT guided intravenous thrombolysis in patients with unknown-onset stroke: a randomized, double-blind, placebo controlled, pilot feasibility trial Michel P, Ntaios G, Reichhart M, Schindler C, Bogousslavsky J, Maeder P, Meuli R, Wintermark M Neuroradiology 2011; 54:579-88 Blood pressure change and outcome in acute ischemic stroke: the impact of baseline values, previous hypertensive disease and previous antihypertensive treatment Ntaios G, Lambrou D, Michel P Journal of Hypertension 2011; 29:1583-9 Temporal distribution and magnitude of the vulnerability period around stroke depend on stroke subtype Ntaios G, Michel P Cerebrovascular Diseases 2011; 32:246-53 CT angiography helps to differentiate acute from chronic carotid occlusion: the "carotid ring sign" P. Michel, G. Ntaios, MG. Delgado, DC. Bezerra, R. Meuli, S. Binaghi Neuroradiology 2012; 54:139-46 Long-term outcome in posterior cerebral artery stroke G. Ntaios, K. Spengos, A. Vemmou, P. Savari, E. Koroboki, G. Stranjalis, K. Vemmos European Journal of Neurology 2011; 18:1074-80 Red cell distribution width does not predict stroke severity or functional outcome Ntaios G, Gurer O, Faouzi M, Aubert C, Michel P. International Journal of Stroke, 2010; 7:2-6 Association between obesity on long-term mortality after acute first-ever stroke: the obesity stroke paradox K. Vemmos, G. Ntaios, K. Spengos, P. Savvari, A. Vemmou, Pappa T, Manios E, Georgiopoulos G, Alevizaki M. Stroke 2011; 42:30-36 The Acute STroke Registry and Analysis of Lausanne (ASTRAL): design and baseline analysis of an ischemic stroke

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registry including acute multimodal imaging P. Michel, C. Odier, M. Rutgers, M. Reichhart, P. Maeder, Re. Meuli, M. Wintemark, A. Maghraoui, M. Faouzi, A. Croquelois, G. Ntaios

Stroke 2010; 41:2491-8 J-shaped association between serum glucose and functional outcome in patients with acute ischemic stroke G. Ntaios, M. Egli, M. Faouzi, P. Michel Stroke 2010; 41:2366-70 Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome G. Ntaios, O. Gurer, M. Faouzi, C. Aubert, P. Michel Cerebrovascular Diseases 2010; 29:484-9 Hypertension is an indepedent predictor of mean platelet volume in patients with acute ischemic stroke G. Ntaios, O. Gurer, M. Faouzi, C. Aubert, P. Michel Internal Medicine Journal 2011; 41:691-5 The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial G. Ntaios, C. Savopoulos, D. Karamitsos, I. Economou, E. Destanis, I. Chryssogonidis, I. Pidonia, P. Zebekakis, C. Polatides, M. Sion, D. Grekas, A. Hatzitolios International Journal of Cardiology 2010; 143:16-9 Implementation of strategy for the management of overt dyslipidemia. The IMPROVE study A. Hatzitolios, V. G. Athyros, A. Karagiannis, C. Savopoulos, C. Charalambous, G. Kyriakidis, Th. Milidis, C. Papathanakis, A. Bitli, I. Vogiatsis, G. Makridis, G. Ntaios, N. Katsiki, A. Symeonidis, D. P. Mikhailidis International Journal of Cardiology 2009; 134(3):322-9 IF: 5.509

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Review articles

Predicting functional outcome and symptomatic intracranial hemorrhage in patients with acute ischemic stroke: a glimpse into the crystal ball? G. Ntaios, V. Papavasileiou, P. Michel, T. Tatlisumak, D. Strbian Stroke 2015, online early Adipokines as mediators of endothelial function and atherosclerosis G. Ntaios, N. Gatselis, K. Makaritsis, G. Dalekos Atherosclerosis 2013; 227:216-21

Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease N. Gatselis, G. Ntaios, K. Makaritsis, G. Dalekos Clinical and Experimental Medicine 2013, in press

Stroke, obesity and gender: a review of the literature Katsiki N, Ntaios G, Vemmos K. Maturitas 2011; 69:239-43 Blood pressure treatment in acute ischemic stroke: a review of studies and recommendations G. Ntaios, P. Bath, P. Michel Current Opinion in Neurology 2009; 23:46-52 The neuroprotective role of erythropoietin in the management of acute ischemic stroke: from bench to bedside G. Ntaios, C. Savopoulos, A. Chatzinikolaou, A. Hatzitolios Acta Neurologica Scandinavica 2008; 118:362-6 Vitamins and stroke: the homocysteine hypothesis still in doubt G. Ntaios, C. Savopoulos, A. Chatzinikolaou, G. Kaiafa, A. Hatzitolios The Neurologist 2008; 14:2-4

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Meta-analyses

Prognostic value of 24-h ABPM in acute ischemic stroke for short, medium and long-term outcome: A systematic review and meta-analysis N. Kakaletsis, G. Ntaios, H. Milionis, A. Haidich, K. Makaritsis, C. Savopoulos, E. Berge, A. Hatzitolios International Journal of Stroke, 2015, online early Intravenous insulin treatment in acute stroke: a systematic review and meta-analysis of randomized controlled trials G. Ntaios, V. Papavasileiou, A. Bargiota, K. Makaritsis, P. Michel International Journal of Stroke 2013, in press

PFO closure vs. medical therapy in cryptogenic stroke: a systematic review and meta-analysis G. Ntaios, V. Papavasileiou, K. Makaritsis, P. Michel International Journal of cardiology 2013; 169:101-5

Non-vitamin-K-antagonists oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack: a systematic review and meta-analysis of randomized controlled trials G. Ntaios, V. Papavasileiou, H.C. Diener, K. Makaritsis, P. Michel Stroke 2012; 43:3298-304 Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis G. Ntaios, C. Savopoulos, S. Chatzopoulos, D. Mikhailidis, A. Hatzitolios

Atherosclerosis 2010; 214(1):11-9