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Transcript of CURRICULUM VITAE Updated May 2015phydatabase.med.miami.edu/documents/cv/Nawaz.Zafar_2739_cv.pdf ·...
1
CURRICULUM VITAE Updated May 2015
I. PERSONAL
Name: Zafar Nawaz
Home Phone:
Cellular Phone:
954-499-0531
954-632-7352
Office Phone:
Fax:
305-243-1456
305-243-6170
Home Address: 3850 Windmill Lakes Road
Weston, FL 33332
Current Academic Rank: Professor
Current Track of Appointment: Tenure
Primary Department: Biochemistry & Molecular Biology
University of Miami School of Medicine
Joint Appointment: UM/SCCC Braman Family Breast Cancer
Institute
Citizenship: United States of America
II. HIGHER EDUCATION
Institutional
December 1992- April 1995 Post Doctoral Fellow
Cell Biology, Baylor College of Medicine, Houston, Texas, USA.
Area of Research: To unravel the Molecular Mechanism of Action
of Nuclear Hormone Receptors with Specific Emphasis on
Estrogen and Progesterone Receptors, Coactivators and
Corepressors and to study the role of the ubiquitin-proteasome
pathway in steroid hormone receptor functions.
1987- 1992 Ph.D.
University of North Texas, Denton, Texas, USA.
Thesis: Molecular Mechanism of Action of Steroid Hormone
Receptors.
1983- 1985 Master of Science
University of Karachi, Pakistan
Major- Genetics
Minor- Bacterial Genetics
Thesis: Isolation, Characterization and Genetic Studies of
Rhizobium Species.
1981- 1983 Bachelor of Science, University of Karachi, Pakistan
Major- Biology
Minor- Chemistry
2
III. EXPERIENCE
Academic
University of Miami Miller School of Medicine, Office of Graduate & Postdoctoral Studies, Senior
Associate Dean, July 2012 – Present.
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular
Biology, Director BS/PhD Program (developed first of its kind in biological sciences in the
nation accelerated dual BS/PhD program), September 2011 – June 2012.
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular
Biology, Professor, June 1, 2010 – Present.
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular
Biology, Graduate Program Director, 2009 – June 2012.
University of Miami Miller School of Medicine SCCC Braman Family Breast Cancer Institute,
Associate Research Director, December 1, 2004 - To date.
Allama Iqbal Medical College, Lahore, Pakistan. Foreign Professor, January 2010 – Present.
University of the Punjab, Lahore, Pakistan. Foreign Professor, 2004 -Present.
Jilian University, China. Visiting professor, 2004 -To date.
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular
Biology, Associate Professor, December 1, 2004 – May 31, 2010.
Creighton University, Omaha, Nebraska, Associate Professor-Department of Surgery, Medical
Microbiology & Immunology and Cancer Center, 2002 - 2004.
Creighton University, Omaha, Nebraska, Director, Cancer Center Molecular Biology Core Lab,
2002 - 2004.
Baylor College of Medicine, Houston, Texas, Assistant Professor - Department of Cell Biology,
1997 - 2002.
Baylor College of Medicine, Houston, Texas, Instructor - Department of Cell Biology, 1995 - 1997.
Baylor College of Medicine, Houston, Texas, Research Associate - Department of Cell Biology,
1989 – 1995.
University of the Punjab, Lahore, Pakistan, Lecturer - Center for Advanced Molecular Biology,
1986 – 1987.
University of the Punjab, Lahore, Pakistan, Research Fellow - Center for Advanced Molecular
Biology, 1985 – 1986.
IV. PUBLICATIONS
Books and Monographs (9 Book Chapters)
1. Buffa L and Nawaz Z. (2012) Estrogen receptor coregulators and breast cancer. In press for The
Research and Biology of Cancer. Editors: iConcept Press Ltd. Brisbane, Australia.
2. Sun J, Zhou W, Nawaz Z, Slingerland JM. (2011) Cross Talk between ERα and Src signaling and
its relevance to ER status and hormone responsiveness. In: Advances in Rapid Sex-Steroid Action:
New Challenges and New Chances in Breast and Prostate Cancers. Editors: Gabriella Castoria and
Antimo Migliaccio, Springer, New York.
3. Srinivasan S and Nawaz Z. (2009) Molecular biology of estrogen receptor. In: Molecular
Mechanisms of Hormone Actions on Behavior. Editors: Anne M. Etgen and Donald W. Pfaff.
Elsevier Inc.
3
4. Srinivasan S, and Nawaz Z. (2009) Molecular Biology of Estrogen Receptor Action. In: Hormones,
Brain and Behavior, 2nd edition, Vol 2. Editors: Donald W. Pfaff, Arthur P. Arnold, Anne M.
Etgen, Susan E. Fahrbach and Robert T. Rubin. San Diego: Academic Press; pp. 1187-1218.
5. Ismail A., Catoe H., Dhananjayan S. and Nawaz Z. (2008) The Ubiquitin-Proteasome Pathway:
Regulation of Nuclear Hormone Receptor Functions. In: Nuclear Receptor Coregulators and
Human Diseases. Editors: Rakesh Kumar and Bert O’Malley. World Scientific Publishing Co. Pte.
Ltd. pp.163-193
6. McKenna N.J., Nawaz Z., Tsai S.Y., and Tsai M.J. (2000) Coactivators and Corepressors. In:
Principles of Molecular Regulation. Editors: P.M. Conn, and A.R. Means. Humana Press, Totowa,
New Jersey. pp.385-394.
7. Lonard, D.M., and Nawaz Z. (2000) Coactivators and Corepressors. In: Nuclear Receptors and
Genetic Disease. Editors; T.P. Burris and E. McCabe. Academic Press Ltd. pp. 389-408.
8. Nawaz Z., Smith D.W. and McDonnell D.P. (1991) Expression of Functional Vitamin D3 Receptor
in E. coli. In: Vitamin D; Gene Regulation, Structure-Function Analysis and Clinical Application.
Editors: A. W. Norman, R. Bouillon and M. Thomasset. Walter De Gruyter Inc. pp. 50-51.
9. Santiso-Mere D., Nawaz Z., McDonnell D.P. and O'Malley B.W. (1991) The Development of
Saccharomyces Cerevisiae as a Host System for Steroid Hormone Action Studies. In: Hormone
Action and Molecular Endocrinology, 15th edition. Editors: M. R. Huges, W. T. Schrader and B.
W. O'Malley. Houston Biological Associates Inc. pp. 23-1- 23-24.
Refereed Journal Articles (81 Articles)
1. Zhou W., Srinivasan S., Nawaz Z., and Slingerland J.M. 2013. ERα, SKP2 and E2F-1 form a feed
forward loop driving late ERα targets and G1 cell cycle progression. Oncogene. Jun 17 [Epub ahead
of print]
2. El Hokayem J. and Nawaz Z. 2014. E6AP in the Brain: One Protein, Dual Function, Multiple
Diseases. Mol. Neurobiol. 49(2):827-39. Cover article.
3. El Hokayem J. and Nawaz Z. 2013. The Transcriptional Coactivation Function of E6-Associated
Protein in the Brain: Novel Insights into the Pathobiology of Debilitating Neurogenetic Diseases.
Mol. Cell. [In Preparation]
4. Srinivasan S. and Nawaz Z. 2013. Transcriptional Profiling Reveals Cell Cycle Regulation by an
E3 Ligase Enzyme, E6-Associated Protein in Breast Cancer Cells. PLOS One. [Submitted]
5. Buffa L., Saeed A. and Nawaz Z. 2013. Molecular mechanism of WW-Domain Binding Protein-2
Coactivation Function in Estrogen Receptor Signaling. IUBMB. 65(1):76-84
6. Sun J., Zhou W., Kaliappan K., Nawaz Z. and Slingerland J.M. 2012. ERα phosphorylation at
Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target
Gene Expression. Mol. Endo. 26(9):1567-77
4
7. McDonald C., Buffa L., Bar-Mag T., Salah Z., Bhat V., Mikles D.C., Deegan B.J., Seldeen K.L.,
Malhotra A., Sudol M., Aqeilan R.I., Nawaz Z. and Farooq A. 2012. Biophysical Basis of the
Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors. J. Mol. Biol. 422(1):58-74.
8. Andreev V.P, Petyuk V., Brewer H., Karpievitch Y.V., Xie F., Clarke J., Camp D.G., Smith R.D.,
Lieberman A.P., Albin R.L., Nawaz Z., Hokayem J.E. and Myers A.J. 2012. Label-Free
Quantitative LC-MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains. J
Proteome Res. 2012 May 5. [Epub ahead of print]
9. Kausar H., Gull S., Ijaz B., Ahmad W., Sarwar MT., Iqbal Z., Nawaz Z., Riazuddin S. and Hassan
S. 2011. Huh-7 cell line as an alternative cultural model for the production of human like
erythropoietin (EPO). J Transl Med. 9(1):186.
10. Ashfaq U.A., Masoud M.S., Nawaz Z. and Riazuddin S. 2011. Glycyrrhizin as antiviral agent
against Hepatitis C Virus. J Transl Med. 9:112.
11. McDonald C., McIntosh S.K.N., Mikles D., Bhat V., Deegan B.J., Seldeen K.L., Saeed A.M., Buffa
L., Sudol M., Nawaz Z. and Farooq A. 2011. Biophysical Analysis of Binding of WW Domains of
the YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors.
Biochemistry. 50(44):9616-27.
12. Ramamoorthy S., Tufail R., El Hokayem J., Jorda M., Zhao W., Reis I. and Nawaz Z. 2011.
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary
tumorigenesis. Breast Cancer Research and Treatment 132(1):97-108.
13. Tufail R., Jorda M., Zhao W., Reis I. and Nawaz Z. 2011. Loss of Yes-associated protein (YAP)
expression is associated with estrogen and progesterone receptors negativity in invasive breast
carcinomas. Breast Cancer Research and Treatment. 131(3):743-50.
14. Catoe, H.W. and Nawaz, Z. 2011. E6-AP Facilitates p300 Recruitment to Estrogen Responsive
Promoter to Allow Efficient Transcription. Steroids. 76(9):897-902.
15. Abdeen S.K., Salah Z. Maly B., Smith Y., Tufail R., Abu-Odeh M., Zanesi N., Croce C.M., Nawaz
Z. and Aqeilan R.I. 2011. Wwox inactivation enhances mammary tumorigenesis.
Oncogene. 30(36):3900-6. doi: 10.1038/onc.2011.115.
16. Ashfaq U.A., Masoud M.S., Khaliq S., Nawaz Z. and Riazuddin S. 2011. Inhibition of Hepatitis C
Virus 3a genotype entry through Glanthus Nivalis Agglutinin. Virol J. 8:248.
17. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazzudin S. 2011. Lysosomotropic agents as
HCV entry inhibitors. Virol J. 8(1):163.
18. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazuddin S. 2011. An overview of HCV
Molecular biology, replication and immune responses. Virol J. 8:161.
19. Ashfaq U.A., Khan S.N., Nawaz Z. and Riazuddin S. 2011. In-vitro model systems to study
Hepatitis C Virus. Genet Vaccines Ther. 9:7.
20. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazuddin S. 2011. Inhibition of HCV 3a core
gene through Silymarin and its fractions. Virol J. 8:15.
5
21. Ramamoorthy S., Dhananjayan S.C., DeMayo F.J. and Nawaz Z. 2010. Isoform specific
degradation of PR-B by E6-AP is critical for normal mammary gland development. Mol.
Endocrinol. 24(11):2099-113.
22. Srinivasan S. and Nawaz Z. 2010. E3 Ubiquitin Protein Ligase, E6-Associated Protein (E6-AP)
Regulates PI3K-Akt Signaling and Prostate Cell Growth. Biochim Biophys Acta. 1809(2):119-27.
23. Fu W., Ma Q., Chen L., Li P., Zhang M., Ramamoorthy S., Nawaz Z., Shimojima T., Wang H.,
Yang Y., Shen Z., Zhang Y., Zhang X., Nicosia S.V., Zhang Y., Pledger J.W., Chen J. and Bai W.
2009. MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and
Degradation. J Biol Chem. 284(21):13987-4000.
24. Ramamoorthy, S., and Nawaz, Z. 2008. E6-associated protein is a dual function coactivator of
steroid hormone receptors. The Nuclear Receptor Signaling. 6:e006.
25. Sun J., Nawaz Z. and Slingerland J. 2007 Long-Range Activation of GREB1 by Estrogen Receptor
via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells. Mol
Endocrinol. 21(11): 2651-2662.
26. Chu I., Arnaout A., Loiseau S., Sun J., Seth A., McMahon C., Chun K., Hennessy B., Mills G.B.,
Nawaz Z. and Slingerland J. 2007 Src promotes estrogen-dependent estrogen receptor alpha
proteolysis in human breast cancer. J Clin Invest.; 117(8):220.
27. Burjonrappa S.C., Reddimasu S., Nawaz Z., Gao X., Sharma P. and Loggie B. (2007) Mucin
expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.
Indian J Cancer, 44(1):1-5.
28. Rapuri P.B., Gallagher J.C., and Nawaz Z. (2007) Caffeine decreases vitamin D receptor protein
expression and 1,25(OH)(2)D(3) stimulated alkaline phosphatase activity in human osteoblast
cells. J Steriod Biochem Mol Biol., 103(3-5):368-71.
29. Dhananjayan S.C., Ramamoorthy S., Khan O.Y., Ismail A., Sun J., Slingerland J., O'Malley B.W.,
and Nawaz Z.. (2006) WW-domain binding protein-2 (WBP-2), an E6-AP interacting protein acts
as a coactivator of estrogen and progesterone receptors. Mol. Endocrinol., 20(10):2343-54.
30. Khan O.Y., Fu G., Ismail A., Srinivasan S., Cao X., Tu Y., Lu S. and Nawaz Z. (2006)
Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the
prostate gland. Mol Endocrinology, 20(3):544-59.
31. Wu J., Liang Y., Nawaz Z., and Hyder S.M. (2005) Complex agonist-like properties of ICI 182,780
(Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B:
implications for treatment resistance. International Journal of Oncology, 27(6):1647-59.
32. Dhananjayan S., Ismail A. and Nawaz Z. (2005) Ubiquitin and the control of transcription. Essays
in Biochem., 41:69-80. Review.
33. Ismail A. and Nawaz N. (2005) Nuclear hormone receptor degradation and gene transcription: An
Update. IUBMB Life Sciences, 57(7):483-90. Review.
34. Dennis A.P., Lonard D.M., Nawaz Z., O'Malley B.W. (2005) Inhibition of the 26S proteasome
blocks progesterone receptor-dependent transcription through failed recruitment of RNA
polymerase II. J Steroid Biochem Mol Biol., 94(4):337-46.
6
35. Gao X., Mohsin S.K., Gatalica Z., Fu G., Sharma P., and Nawaz Z. (2005) Decreased expression
of e6-associated protein in breast and prostate carcinomas. Endocrinology, 146(4):1707-12.
36. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z.. (2004) Ubiquitin-Conjugating Enzyme,
UBCH7 acts as a coactivator for steroid hormone receptors. Mol Cell Biol., 24(19):8716-26.
37. Liu Z., Shi H.Y., Nawaz Z. and Zhang M. (2004) Tamoxifen induces the expression of maspin
through estrogen receptor-alpha. Cancer Lett., 209: 55-65.
38. Nawaz Z. and O’Malley B.W. (2004) Urban Renewal In The Nucleus: Is Protein Turnover by
Proteasomes Required for Transcription? Mol. Endo., 18(3):493-9. Review.
39. Khan O.Y. and Nawaz Z. (2003) Nuclear hormone receptor co-regulators. Current Opinion in
Drug Discovery & Development, 6(5):692-701. Review.
40. Yan F., Gao X., Lonard D. and Nawaz Z. (2003) Specific ubiquitin-conjugating enzymes promote
degradation of specific nuclear receptor coactivators. J Steroid Biochem Mol Biol., 17(7):1315-31.
41. Pearce V., Nawaz Z., Xiao W., Wiedenfled D., Boyle N. and Smith D. (2003) 4-
Ethoxymethylphenol: A novel estrogen that acts as an agonist for human estrogen receptors. Steroid
Biochem. And Mol. Biol., 84: 431-439.
42. Gao X., Loggie B.W. and Nawaz Z. (2002) The roles of sex steroid receptor coregulators in cancer.
Molecular Cancer, 1: 1-7.
43. Gao X. and Nawaz Z. (2002) Role of steroid receptor coactivators and corepressors of progesterone
receptors in breast cancer. Breast Cancer Res., 4(5):182-6.
44. Smith C.L., DeVera D.G., Lamb D.J., Nawaz Z., Jiang Y.H., Beaudet A.L. and O’Malley B.W.
(2002) Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in
Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Molecular and
Cellular Biology, 22(2):525-35.
45. Dennis A.P., Haq R.U., and Nawaz Z. (2001) Importance of the regulation of nuclear receptor
degradation. Front. Bioscience, 6:D954-9.
46. Zhao H., Herrera R.E., Coronado-Heinsohn E., Yang M.C., Ludes-Meyers J.H., Seybold-Tilson
K.J., Nawaz Z., Yee D., Barr F.G., DiabS.G., Brown P.H., Fuqua S.A., and Osborne C.K. (2001)
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-
interacting protein with both coactivator and corepressor functions. J Biol Chem., 276(30):27907-
12.
47. Sivaraman L., Nawaz Z., Medina D., Conneely O.M., and O’MalleyB.W. (2000) The novel dual
function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in
mouse mammary tumorigenesis. Breast Cancer Research and Treatment, 62(3):185-95.
48. Hyder S.M., Huang J.C., Nawaz Z., Tong H.B., Makela S., Chiappetta C. and Stancel G. (2000)
The Regulation of vascular endothelial growth factor expression by estrogens and progestins.
Environmental Health Prospectives, 108 Suppl 5:785-90.
49. Li J., Wang J., Wang J., Nawaz Z., Liu J.M., Qin J., and Wong J. (2000) Both corepressors SMRT
and N-CoR proteins exist in large protein complexes containing HDAC3. EMBO, 19(16):4342-50.
7
50. *Lonard D.M., *Nawaz Z., Smith C.L., and O’Malley B.W. (2000) The 26S proteasome is required
for estrogen receptor- and coactivator turnover and for efficient estrogen receptor-
transactivation. Molecualr Cell, 5(6):939-48.
*Equal contribution.
51. Hyder S.M., Nawaz Z., Chiappetta C., and Stancel G. (2000) Detection of classical and atypical
estrogen response elements in the untranslated regions of the rat VEGF gene. Cancer Research,
60(12):3183-90.
52. McKenna N.J., Xu J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1999) Nuclear receptor
coactivator: Multiple enzymes, multiple complexes, multiple functions. J. Steroid Biochem. Mol.
Bio., 69(1-6):3-12.
53. Robinson C.E., Wu X., Nawaz Z., Onate S.A. and Gimble J.M. (1999) A corepressor and chicken
ovalbumin upstream promoter transcription factor proteins modulate peroxisome proliferator-
activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine
lipoprotein lipase promoter. Endocrinology, 140(4):1586-93.
54. Nawaz Z., Lonard D. M., Dennis A. P., Smith C. L. and O’Malley B.W. (1999) Proteasome-
dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci. USA, 96(5):1858-
62.
55. Nawaz Z., Standcel G.M. and Hyder S.M. (1999) The pure antiestrogen ICI 182780 inhibits
progestin-induce transcription. Cancer Res., 59(2):372-6.
56. Nawaz Z., Lonard D.M., Smith C.L., Lev-Lehman E., Tsai S.Y., Tsai M.J. and O’Malley B.W.
(1999) The Angelman syndrome-associated gene, E6-AP, is also a coactivator for nuclear hormone
receptor superfamily. Mol. Cell. Bio., 19(2):1182-9.
57. McKenna N.J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1998) Distinct steady state
nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci U S A. 95(20):11697-702.
58. Shibata H., Nawaz Z., Tsai S.Y., O’Malley B.W. and Tsai M.J. (1997)Gene silencing by chicken
ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional
corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid
receptor and thyroid hormone receptor (SMRT). Mol Endocrinol. 11(6):714-24.
59. Smith C.L., Nawaz Z. and O’Malley B.W. (1997) Coactivator and corepressor regulation of the
agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol.
11(6):657-66.
60. Xu J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1996) The extreme carboxyl-terminus
of progesterone receptor contains a transcriptional repressor domain that functions through a
putative corepressor. Proc Natl Acad Sci U S A. 93(22):12195-9.
61. Nawaz Z., Tsai M.J. and O’Malley B.W. (1995) Specific mutations in the ligand binding domain
selectively abolish the silencing function of human thyroid receptor ß. Proc. Natl. Acad. Sci. USA.,
92(25):11691-5.
62. Burris T.P., Nawaz Z., Tsai M.J. and O'Malley B.W. (1995) A nuclear hormone receptor-
associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.
Proc. Natl. Acad. Sci. USA, 92(21):9525-9.
8
63. Hyder S., Nawaz Z., Chiappetta C., Yokoyama K. and Stancel G.M. (1995) Protooncogene c-jun
contains an unusual estrogen inducible enhancer within the coding sequences. J. Biol. Chem.,
92(21):9525-9.
64. Baniahmad C., Nawaz Z., Baniahmad A., Gleeson M., Tsai M.J. and O'Malley B.W. (1995)
Enhancement of human estrogen receptor activity by SPT6: A potential Co-activator. Mol. Endo.,
9(1):34-43.
65. Nawaz Z., Baniahmad C., Stillman D.J., Burris T., O'Malley B.W. and Tsai M.J. (1994) The yeast
SIN3 gene negatively regulates the activity of the human progesterone receptor and positively
regulates the activities of GAL4 and the HAP1 activator. Mol. General Genetics, 245(6):724-33.
66. Fuqua S.A.W., Allred D.C., Elledge R.M., Krieg S.L., Benedix M.G., Nawaz Z., O'Malley B.W.,
Green G.L. and McGuire W.L. (1993) The ER-positive/ PgR-negative breast cancer phenotype is
not associated with mutations within the DNA binding domain. Breast Cancer Res. and Treatment,
26(2):191-202.
67. Nawaz Z., Stancel G.M., McDonnell D.P. and Hyder S.M. (1993) Creation of an active estrogen-
responsive element by a single base change in the flanking sequence of a cellular oncogene: A
possible mechanism for hormonal carcinogenesis? Mol. Carcinogenesis, 7(2):76-82.
68. Hyder S.M., Stancel G.M., Nawaz Z., McDonnell D.P. and Loose-Mitchell D.S. (1992)
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos
protooncogene. J. Biol. Chem., 267(25):18047-54.
69. Nawaz Z., Tsai M.J., McDonnell D.P. and O'MalleyB.W. (1992) Identification of novel steroid
responsive elements. Gene Expression, 2(1):39-47.
70. Fuqua S.A.W., Fitzgerald S.D., Allred D.C., Elledge R.M., Nawaz Z., McDonnell D.P., O'Malley
B.W., Green G.L. and McGuire W.L. (1992) Inhibition of estrogen receptor action by naturally
occurring variant in human breast tumors. Cancer Res., 52(2):483-6.
71. McDonnell D.P., Nawaz Z. and O'Malley B.W. (1991) In situ distinction between steroid receptor
binding and transactivation at a target gene. Mol. Cell. Bio., 11(9):4350-5.
72. McDonnell D.P., Nawaz Z., Densmore C., Weigal N.L., Pham T.A., Clark J.H. and O'Malley B.W.
(1991) High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.
J. Steroid Biol. and Mol. Biol, 39(3):291-7.
73. Pham T.A., Elliston J.F., Nawaz Z., McDonnell D.P., Tsai M.J. and O'MalleyB.W. (1991)
Antiestrogen can established nonproductive receptor complexes and alter chromatin structure at
target enhancers. Proc. Natl. Acad. Sci. USA. 88(8):3125-9.
74. Fuqua S.A.W., Fitzgerald S.D., Chamness G.C., Tandon A.K., McDonnell D.P., Nawaz Z.,
O'Malley B.W. and McGuire W.L. (1991) Variant human breast tumor estrogen receptor with
constitutive transcriptional activity. Cancer Res., 51(1):105-9.
75. Witliff J.L., Wenz L.L., Dong J., Nawaz Z. and Butt T.R. (1990) Expression and characterization
of an active human estrogen receptor as a ubiquitin fusion protein from Escherichia coli. J. Biol.
Chem., 265(35):22016-22.
9
76. Riazuddin S., Sohail A. and Nawaz Z. (1987) Isolation of temperate bacteriophage phi R7 specific
for Pseudomonas aeruginosa. Pak. J. of Zool., 19(3), 290-298.
77. Raufa A., Nawaz Z., Riazuddin S. and Shakoori A.R. (1987) Isolation, characterization and genetic
studies of Rhizobium meliloti. Pak. J. of Zool., 19(2), 120-124.
78. Neelam M., Nawaz Z. and Riazuddin S. (1987) Hydrocarbon Biodegradation: Biochemical
characterization of bacteria isolated from local soils. Pak. J. of Sci. and Indus., Res. 30, 282-285.
79. Neelam M., Nawaz Z., Shakoori A.R. and Riazuddin S. (1987) Isolation and characterization of
R- factor (plasmids) from antibiotic resistant strains collected from local hospitals. Pak. J. of Zool.,
19(1), 17-26.
80. Nawaz Z. and Ahmad N. (1987) Isolation and characterization of Rhizobium species as nitrogen
fixing symbionts in Guar (Cymopsis tetragonoloba (L) Taub). Pak. J. of Zool., 19(1), 9-15.
81. Riazuddin S., Shakoori A.R. and Nawaz Z. (1986) Mutagenicity testing of children’s consumables.
Pak. J. of Zool., 18(3), 325- 334.
Abstracts
1. El Hokayem J. and Nawaz Z. 2014. The transcriptional coactivation function of E6AP in Angelman
syndrome and related diseases. Miami Winter Symposium 2014, Miami, FL
2. El Hokayem J., Garcia A., Obeid J.P., Weeber E. and Nawaz Z. 2012. The Angelman Syndrome
protein E6AP transcriptionally regulates the expression of the retinoic acid catabolizing enzyme
CYP26B1 through Estrogen Receptor Signaling. FASEB, Snowmass Village, CO
3. El Hokayem J., Garcia A., Obeid J.P., Weeber E. and Nawaz Z. 2012. The Angelman Syndrome
protein E6AP transcriptionally regulates the expression of the retinoic acid catabolizing enzyme
CYP26B1 through Estrogen Receptor Signaling. Endocrine Society Annual Meeting. Houston, TX
4. Buffa L. and Nawaz Z. 2012. Molecular mechanism of WBP-2 coactivation function in Estrogen
Receptor transactivation. AACR annual Meeting. Chicago, IL
5. El Hokayem J. and Nawaz Z. 2011. The Angelman Syndrome protein E6AP transcriptionally
regulates the expression of the retinoic acid metabolizing enzyme CYP26B1 through Estrogen
Receptor Signaling. Keystone Symposia: Environmental Epigenomics. Asheville, NC
6. Srinivasan S. and Nawaz Z. 2010. Steroid Hormone Receptor Coactivator, E6-Associted Protein
(E6-AP) Regulates PI3K-Akt Signaling and Cell Growth. FASEB, Snowmass Village, CO
7. Catoe H.W. and Nawaz Z. 2010. E6-AP Facilitates p300 Recruitment to an Estrogen Responsive
Promoter to Allow Efficient Transcription. Endocrine Society Annual Meeting. San Diego, CA
8. Kilroy G., Burk D.H., Ramamoorthy S., Nawaz Z. and Floyd E. 2010. Identification of Ubiquitin
Ligases that Regu
SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases. Houston, TX.
9. Ramamoorthy S. and Nawaz Z. 2009. RE6-AP Mediated Proteolysis of PR-B Regulates Mammary
Gland Tumorigenesis by Modulating the Wnt Signaling Pathway. Endocrine Society Annual
Meeting. Washington, D.C.
10
10. Srinivasan S., Pedroso I.M. and Nawaz Z. 2009. Role of E6-AP in Estrogen Dependent
Transcriptome of MCF-7 Breast Cancer Cells. Endocrine Society Annual Meeting. Washington,
D.C.
11. Dhananjayan S., Ramoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively
Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. Cold Spring Harbor Lab,
NY.
12. Ramamoorthy S., Dhananjayan S. and Nawaz Z. 2008. E6-Associated Protein (E6-AP) Regulates
Mammary Gland Morphogenesis by Modulating the Ubiquitin-Mediated Proteolysis of the
Progesterone Receptor. Cold Spring Harbor Lab, NY.
13. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively
Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. DOD – Era of Hope
Meeting.
14. Srinivasan S., Ismail I., Rudd K.E., Zhou J. and Nawaz Z. 2008. Genome Wide Analysis of
Estrogen DependentE6-AP Binding Sites in MCF-7 Breast Cancer Cells. Endocrine Annual
Meeting.
15. Ramamoorthy S., Dhananjayan S.C., Zafar S. and Nawaz Z. 2007. E6-Associateed Protein is a Cell
Growth Regulator in Mammary Gland. The Endocrine Society Annual Meeting.
16. Dhananjayan S.C., Ramamoorthy S. and Nawaz Z. 2007. Oncogenic WW-domain containing
oxidoreductase negatively regulates the coactivation functions of WW-domain binding protein-2
and yes-associated protein 1. The Endocrine Society Annual Meeting.
17. Srinivasan S., Zafar S. and Nawaz Z. 2007. Transcriptional Regulation of MUC2 by Estrogen.
ASCO Gastrointestinal Cancers Symposium.
18. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-associated protein (E6-AP): A potential tumor
suppressor protein. AACR Annual Meeting.
19. Fu G., Srinivasan S., Dhananjayan S., Zafar S. and Nawaz Z. 2007. Steroid Hormone Receptor
Coactivator, E6-Associated Protein (E6-AP) Regulate P13K-Akt Signaling and Prostate Cell
Growth. AACR Annual Meeting.
20. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-Associated Protein (E6-AP): A Potential Tumor
Suppressor Protein. AACR Annual Meeting.
21. Srinivasan S., Zafar S., Nawaz Z. and Loggie B.W. 2006. Transcriptional Regulation of MUC2 by
Estrogen. ASCO GI Annual Meeting.
22. Zafar S., Srinivasan S., and Nawaz Z. 2006. E6-Associated Protein (E6-AP): A Potential Tumor
Suppressor Protein for Colorectal Cancer. ASCO GI Annual Meeting.
23. Zafar S., Srinivasan S. and Nawaz Z. 2006. E6-Associated Protein (E6-AP): A Potential Tumor
Suppressor Protein for Non-Hodgkin Lymphoma. ASH Annual Meeting.
24. Dhananjayan S., Khan O.Y. and Nawaz Z. 2005. Identification and characterization of WW-
domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor
functions. The Endocrine Society Annual Meeting.
11
25. Srinivasan S., Khan O.Y., Fu G., Ismail A., Tu Y., Lu S. and Nawaz Z. 2005. Multifunction steroid
receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate
gland. The Endocrine Society Annual Meeting.
26. Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 Modulates Steroid Hormone Receptor
Functions. 2nd Ubiquitin Conference.
27. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme,
UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with
SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.
28. Loggie B.W., Nawaz Z., Gatalica Z., Silvaand E., and El-Ella G.A. 2004. Inhibition of Mucin 2
production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical Society of
Oncology.
29. El Ella G.A., Gatalica Z. and Nawaz Z. 2004. Inhibition of Mucin production: Implications for
treatment of breast cancer. AACR Meeting.
30. Zafar S., Gao X., Khalid M., Gatalica Z. and Nawaz Z. 2004. E6-associated protein, E6-AP is
involved in the carcinogenesis of human breast and prostate. AACR Meeting.
31. Loggie B.W., El-Ella G.A., Gatalica Z., Silvaand E. and Nawaz Z. 2003. Promising new strategies
for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.
32. Nawaz Z. 2003. Steroid hormone receptor coregulators. Nuclear Receptors as Drug Targets.
33. Verma1 S., Li X., O’Malley B.W. and Nawaz Z. 2003. Ubiquitin Conjugating Enzyme, UBCH7
Act As a Coactivator For Steroid Hormone receptors. The Endocrine Society.
34. Nawaz Z. 2003. Role of Ubiquitin-Proteasome Pathway Enzymes in Steroid Hormone Receptors
Transactivation. NIH meeting on Ubiquitin and Ubiquitin like pathways.
35. Ul Haq R. and Nawaz Z. 2002. Identification and characterization of WW-domain binding proteins
as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine
Society.
36. Gao X., Mohsin S.K., Wheeler T.M., Yan F. and Nawaz Z. 2002. E6-associated protein, E6-AP,
is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine
Society.
37. Verma S., Liu Z., Haq R., O’Malley B.W. and Nawaz Z. 2002. UBCH7, an E2 ubiquitin-
comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone
Symposia.
38. Hopp T.A., Wang C., Pestell R.G., Nawaz Z., Wang M. and Fuqua S.A.W. 2001. A hypersensitive
mutation of estrogen receptor a occurring in premalignant breast disease influences co-activator
binding, receptor acetylation, and stability. The Endocrine Society.
39. Gao X. and Nawaz Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed
in human mammary tumors. The Endocrine Society.
12
40. Hopp T., Allred D.C., Hilsenbeck S., Mohsin S., Nawaz Z., O’Connell P., Pestell R.G. and Fuqua
41. O’Malley B.W., Xu J., Nawaz Z., Lanz R., Barron N., Liu Z., Rowen B., Cavarretta I., Smith C.,
Wong J., Tsai S. and Tsai M.J.. 2000. In vivo roles of steroid receptor coactivators in gene
regulation. The Endocrine Society.
42. Barron N., Nawaz Z., Qin J. and O’Malley B.W. 2000. Effects of the Ccr4/Not complexes on
steroid receptor-dependent transcription. The Endocrine Society.
43. Smith C., De Vera D., Nawaz Z., Jiang Y.H., Beaudet A.L. and O’Malley B.W.. 2000. A null
mutation of the steroid receptor coactivator/ubiquitin ligase E6-AP, negatively impact selected
tissues of the male and female reproductive tract in mice. . The Endocrine Society.
44. Dennis A., Nawaz Z. and O’Malley B.W. 2000. Characterization of UBA3: A novel type of nuclear
hormone receptor coactivator. The Endocrine Society.
45. Nawaz Z., Lonard D.M., Smith C.L. and O’Malley B.W. 2000. Regulation of Gene Expression by
the Nuclear Hormone Receptor-Coactivator Complex Requires the Ubiquitin-Proteasome Pathway.
The Endocrine Society.
46. O’Malley B.W., Xu J., Nawaz Z., Lanz R., Wu R., Leonard D.M., Liu Z., Cavarretta I., Smith C.,
Wong J., Tsai S. and Tsai M.J. 2000. Roles of steroid receptor co-activators in transcriptional
regulation in vitro and in vivo. The Key Stone Symposia.
47. Cox G.W., Nawaz Z. and Johnson G.V.W. 2000. Analysis of a unique nuclear transglutaminase
(TGase) substrate expressed in macrophages. American Association of Immunology Meeting.
48. Lonard D.M., Smith C.L., Nawaz Z. and O’Malley B.W. 2000. Ligand-mediated down-regulation
of estrogen receptor-alpha depends upon intact AF-2 coactivator-binding surfaces. The Key Stone
Symposia.
49. Nawaz Z. and O’Malley B.W. 2000. The Nuclear Hormone Receptor Coactivators are Targets of
the Ubiquitin-Proteasome Pathway. The Key Stone Symposia.
50. O’Malley B. W., Lanz R., Xu J., Nawaz Z., Lonard D., Smith C. L., Tsai S. Y., and Tsai M. J.
1999. Role of steroid receptor coactivators in transcriptional regulation. The Endocrine Society.
51. Hyder S. Nawaz Z., and Stancel G. 1999. A novel antiprogestin activity associated with the pure
antiestrogen ICI 182,780: Inhibition of progesterone receptor mediated gene expression. The
Endocrine Society.
52. Hyder S. M., Chiappetta, Nawaz, Z., and Stancel G. 1999. Detection of two estrogen receptor
binding sites located in the 5’ and 3’ untranslated regions of the VEGF gene. The Endocrine
Society.
53. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Ludes-Meyers J.H., Nawaz Z., Herrera R.E.,
Yee D., Brown P.H., Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.A.W. and Osborne K. 1999.
FKHR, a bifunctional nuclear receptor intermediary protein, inhibits estrogen-dependent human
breast cancer cell growth. The Endocrine Society.
13
54. Nawaz Z., Lonard D.M., Dennis A. P., Smith C.L., and O’Malley B.W. 1999. Proteasome-
dependent degradation of the human estrogen receptor. The Endocrine Society.
55. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Nawaz Z., Herrera R.E., Yee D., Brown P.H.,
Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.W.A. and Osborne K. 1999. FKHR, a novel nuclear
receptor interacting protein that functions as both a coactivator and corepressor. AACR Meeting
(The Steroid Receptor Superfamily).
56. Lonard D.M., Nawaz Z., Smith C.L. and O’Malley B.W. 1999. Involvement of ubiquitin-
proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid
Receptor Superfamily).
57. Hyder S., Nawaz Z., Stancel G.M. 1999. The pure antiestrogen ICI182,780 exhibits a novel
antiprogestin activity and inhibits progesterone receptor dependent gene expression. AACR Annual
Meeting.
58. Lehman E.L., Nawaz Z., Benton C., Dicks D. and Beaudet A. 1998. Analysis of mutations causing
Angelman Syndrome: mRNA stability and UBA3 activity. American Society of Human Genetics.
59. Nawaz Z., Lonard D., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The angelman
syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The
Endocrine Society.
60. Lonard D., Nawaz Z., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The ubiquitin-
protein ligase E6-AP, mutated in angelman syndrome, is a steroid receptor coactivator. The Key
Stone Symposia.
61. Nawaz Z., Lonard D., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The angelman
syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The
Key Stone Symposia.
62. Smith C.L., Nawaz Z., and O’Malley B.W. 1997. Transcriptional coregulators modulate the
relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to activate the estrogen
receptor. The Endocrine Society.
63. Shibata H., Nawaz Z., Tsai S.Y., O’Malley B.W. and Tsai M.J. 1997. Gene silencing by COUP-
TFI mediated by transcriptional corepressors N-CoR and SMRT. The Endocrine Society.
64. Shibata H., Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Cloning of corepressors for the thyroid
hormone receptor with yeast two-hybrid system. The Endocrine Society.
65. Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Specific mutations in the ligand binding domain
selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia.
66. Burris T.P., Nawaz Z., Tsai S.Y., Tsai M.J. and O'Malley B.W. 1995. Interaction cloning of a
protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors.
The Endocrine Society.
67. Chiappetta C., Nawaz Z., Stancel G.M., and Hyder S.M. 1994. Different nucleotide requirements
for estrogen receptor binding and hormone dependent transcriptional activation defines a novel
estrogen responsive element within the coding sequence of c-jun. IX International Congress on
Hormonal Steroids.
14
68. Nawaz Z., Stillman D., Burris T., O'Malley B.W. and Tsai M.J. 1994. The yeast SIN3 gene
negatively regulates the transcriptional activity of the human progesterone receptor and positively
regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society.
69. Hyder S.M., Nawaz Z. and Stancel G.M. 1993. A single base change in the flanking sequence of
a cellular oncogene creates an active estrogen response element- A possible mechanism of
hormonal carcinogenesis? The Endocrine Society.
70. Baniahmad C., Nawaz Z., Tsai M.J. and O'Malley B.W. 1992. Identification and isolation of co-
activator for steroid hormone receptors using a yeast host system. Santa Cruiz Summer Conference.
71. Hyder S.M., Loose-Mitchell D.S., Nawaz Z. and Stancel G.M. 1992. A 32 base pair
deoxyoligonucleotide derived from murine c-fos protooncogene binds estrogen receptor. The
Endocrine Society.
72. Fuqua S.A.W., Allred D.C., McDonnell D.P., Nawaz Z., O'Malley B.W., Green G.L. and McGuire
W.L. 1992. A dominant-positive variant estrogen receptor conferes resistance to endocrine therapy
in human breast cancer cells. The Endocrine Society.
73. Paslidis N., Baniahmad C., Nawaz Z., McDonnell D.P., Tsai M.J. and O'Malley B.W. 1992.
Identification of an 102 KDa protein which interacts with the estrogen receptor in yeast. American
Association of Cancer Research.
74. Nawaz Z., Tsai M.J., McDonnell D.P. and O'Malley B.W. 1992. A system to identify novel steroid
response elements. ASBMB/Biophysical Society.
75. Fuqua S.A.W., Allred D.C., Qui M., Fitzgerald S.D., Benedix M.G., Krieg S.L., McDonnell D.P.,
Nawaz Z., O'Malley B.W., Green G. and McGuire W.L. 1991. Transcriptionally active estrogen-
independent variant estrogen receptors in human breast tumors. Breast Cancer Symposium.
76. Nawaz Z., McDonnell D.P. and O'Malley B.W. 1991. A novel system to identify steroid responsive
elements. Eight Workshop on Vitamin D.
77. Nawaz Z., Smith D.W., McDonnell D.P. and O'Malley B.W. 1991. Expression of functional
vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D.
78. Fuqua S.A.W., Allred D.C., Elledge R.M., Green G.L., Nawaz Z. and McGuire W.L. 1991
Estrogen receptor mRNA variants in breast cancer. The Endocrine Society.
79. McDonnell D.P., Nawaz Z. and O'Malley B.W. 1991. In situ distinction between steroid receptor
binding and transactivation at a target gene. The Endocrine Society.
80. Densmore C.L., McDonnell D.P., Nawaz Z. and Clark J.H. 1990. Expression and characterization
of human estrogen receptor in yeast Saccharomyces cerevisiae. The Cell Biology Society.
81. Fuqua S.A.W., McDonnell D.P., Nawaz Z., O'Malley B.W. and McGuire W.L. 1990. Variant
estrogen receptor RNA transcripts in breast tumors. The Endocrine Society.
82. Butt T.R., McDonnell D.P., Nawaz Z., Bowdin L., Green G. and Drutz D. 1989. Human estrogen
receptor expression in yeast and its regulation by non-steroidal ligands. Yeast Cell Biology. Cold
Spring Harbour.
15
V. PROFESSIONAL
Funded Research Performed
Active Grants
University of Miami Sylvester Comprehensive Cancer Center
Title: “Role of WWOX1 in Estrogen Receptor Level and Function in Breast Cancer”
Funding Period: 2014
Role: PI
Annual Direct: $50,000
Karen Mullen Breast Cancer Foundation
Title: “A Phase II clinical trial of Bortezomib (Velcadeᵀᴹ) in combination with tamoxifen in the
treatment of patients with metastatic triple negative breast cancer previously treated with
chemotherapy”
Funding Period: 2013 – 2015
Role: Co-PI
Annual Direct: $50,000
Total Annual Cost: $50,000
Foundation for Angelman Syndrome Therapeutics GIA2012005 [Grant in aid]
Title: “E6-AP transcriptional targets in the pathogenesis and therapy of AS”
Funding Period: 2/1/2013 – 1/31/2014
Role: PI
Annual Direct: $ 41,460
Total Annual Cost: $ 41,460
NIH-NIDDK RO1 1R01DK079217-01A2
Title: “Roles of Novel Protein Complexes in Estrogen and Progesterone Receptor Signaling”
Funding Period: 1/1/2009 – 12/31/2013
Effort: 40%
Role: PI
Annual Direct: $243,719.19
Total Annual Cost: $342,729.54
NIH-NCI RO1 (Joyce Slingerland) 1R01CA123415-01A2
Title: “Mechanisms whereby Src activates estrogen stimulated ER proteolysis and ER target.”
Funding Period: 4/1/2009 – 3/31/2014
Effort: 15% Role: Co-PI
Annual Direct: $228,170
Total Annual Cost: $344,456
NIH -NIGMS RO1 (Amjad Farooq) 1R01GM083897-01
Title: “Structural and Functional Studies of the Novel DBD Domain of MKP5.”
Funding Period: 4/1/2008 – 3/31/2013
Role: Co-PI
Annual Direct: $250,000
Total Annual Cost: $379,850
16
NIH-NCI T32 (Joyce Slingerland)
Title: “Training in Translational Breast Cancer Research”
Funding Period: 9/19/2007 – 8/31/2013 NCE
Role: Mentor
Annual Direct: $159,114
Total Annual Cost: $171,066
Pending
NIH RO1
Title: “Role of WWOX and Chemical Environmental Factors in Estrogen Receptor Signaling”
Proposed Funding Period: 4/1/2014 – 3/31/2019
Percentile:
Role: Co-PI with Dr. Rami Aqeilan from Ohio State University
Total Direct: $250,000
Research Completed
Bankhead-Coley Pre-SPORE (Joyce Slingerland)
Title: “Role of E6-Associated Protein, E6-AP in the regulation of estrogen receptor turnover and
functions”
Funding Period: 7/1/2009 – 6/30/2011
Effort: 10%
Role: Project Leader
Annual Direct: $101,000
Total Annual Cost: $111,100
NIH-NIDDK RO1 ARRA
Title: “Roles of Novel Protein Complexes in Estrogen and Progesterone Receptor Signaling “
Funding Period: 2/5/2010 – 12/31/2010
Effort: 40%
Role: PI
Annual Direct: $74,700
Total Annual Cost: $74,700
DOD (Sivapriya Ramamoorthy)
Title: “Role of the PY motif containing protein, WBP-2 in ER, PR signaling and breast tumorigenesis.”
Funding Period: 12/1/2005-6/30/2009
Role: Mentor (Z. Nawaz)
Annual Direct Cost: $27,778
Total Annual Cost: $30,000
NIH - R01 (Baxter, Timothy)
Title: MMP-2 Regulation in Aortic Aneurysm
Funding Period: 01/01/05-12/31/2010
Effort: 5%
Role: Collaborator
Annual Direct Cost: $10,000
Total Annual Cost: $15,150
NIH/NIDDK/NCI - R01 Title: “Role of E6-AP in the Development of Prostate Cancer.”
Funding Period: 09/30/01-08/31/2006
Effort: 35%
17
Role: PI (Z. Nawaz)
Annual Direct Cost: $150,000
Total Cost: $878,632
NIH -R01 Title: “Nuclear Hormone Action: Role of Ubiquitin Pathways”.
Funding Period: 02/01/00-06/30/2006
Effort: 40%
Role: Principal Investigator
Annual Direct Cost: $161,023
Total Cost: $878,632
NIH (Wheeloch and J. Margaret)
Nebraska Center for Cellular Signaling
Funding Period: 2003-2004
Effort: 10%
Role on project: Mentor
Direct Cost: $11,500
Total Amount: $16,387
DOD (Gao Xiuhua)
(Breast Cancer Research Grant, DAMD17-02-1-0281)
Title: Involvement of steroid receptor coactivator/ubiquitin pathway enzymes in mammary gland
tumorigenesis.
Funding Period: 5/13/02-05/12/04
Role: Mentor
Direct Cost: $128,703
Total Cost: $139,000
DOD
(Breast Cancer Research Grant, DAMD17-00-1-0142)
Title: Ubiquitin pathway enzymes: Coactivator of nuclear hormone receptors and their role in the
development of breast cancer
Funding Period: 2000-2004
Effort: 15%
Role: Principal Investigator
Direct Cost: $250,575
Total Cost: $336,375
DOD
(Breast Cancer Research Grant, DAMD17-99-9075)
Title: Role of nuclear hormone receptor coactivator, E6-associated protein (E6-AP) in the development
of breast cancer
Funding Period: 1999-2003
Effort: 20%
Role: Principal Investigator
Direct Cost: $225,000
Total Cost: $310,800
18
Editorial Responsibilities
Ad-hoc Reviewer
1. Molecular Endocrinology (1999-Present)
2. Endocrinology (2000-Present)
3. Cancer Research (2004-Present)
4. Molecular and Cellular Biology (2002-Present)
5. Molecular Cell (2006-2008)
6. PNAS (2002-Present)
7. Oncology (2005-Present)
8. Journal of Biological Chemistry (2002-Present)
9. NURSA (2007-Present)
10. J. of Molecular Endocrinology (2006-2009)
11. Molecular Pharmacology (2009-Present)
Editorial Board
1. Journal of Carcinogenesis
2. Frontiers in Cancer Endocrinology (2013-Present)
Professional and Honorary Organizations
The Endocrine Society (1999-Present)
American Society of Microbiology (1994-1995)
The American Cancer Society (2005-Present)
American Association for the Advancement of Science (2002-Present)
Phi Beta Delta Honor Society (1988-1990)
Tri Beta Biological Honor Society (1989-1991)
Phi Kappa Phi Honor Society (1988-1992)
Honor Society of International Scholars (1990-1992)
Who’s Who (1995)
Honors and Awards
Scholarship awarded by US Academy for Educational Development, 1987-1991.
Competitive Botany Research Award, University of North Texas, 1991-1992.
Ronald K. Harmon Dissertation Award for Research Achievement in the Applied Life Sciences,
University of North Texas, 1992.
Davenport/Flaming Award, Texas Medical Center, 1998.
Travel Award from Endocrine Society, 1999.
Distinguish Alumni Award from University of North Texas, 2000.
Post- Doctoral Fellowship
December 1992- April 1995: Post Doctoral Fellow
Cell Biology, Baylor College of Medicine, Houston, TX, USA
Area of Research: To unravel the Molecular Mechanism of Action of
Nuclear Hormone Receptors with Specific Emphasis on
Estrogen and Progesterone Receptors, Coactivators and Corepressors and
to study the role of the ubiquitin-proteasome pathway in steroid hormone
receptor functions
19
Other Professional Activities
Clinical Trials
SCCC 2009029: 2012. A Phase II Clinical Trial of BORTEZOMIB (Velcade) in combination with
Tamoxifen in the treatment of patients with metastatic triple negative breast cancer previously
treated with chemotherapy. [PI: Stephan Glück; Co-PI: Zafar Nawaz]
Poster presentations
1. Buffa L. and Nawaz Z. 2012. Molecular mechanism of WBP-2 coactivation function in Estrogen
Receptor transactivation. AACR annual Meeting. Chicago, IL.
2. El Hokayem J. and Nawaz Z. 2011. The Angelman Syndrome protein E6AP transcriptionally
regulates the expression of the retinoic acid metabolizing enzyme CYP26B1 through Estrogen
Receptor Signaling. Keystone Symposia: Environmental Epigenomics. Asheville, NC.
3. Catoe H.W. and Nawaz Z. 2010. E6-AP Facilitates p300 Recruitment to an Estrogen Responsive
Promoter To Allow Efficient Transcription. Endocrine Society Annual Meeting. San Diego, CA.
4. Srinivasan S., Pedroso I.M. and Nawaz Z. 2009. Role of E6-AP in Estrogen Dependent
Transcriptome of MCF-7 Breast Cancer Cells. Endocrine Society Annual Meeting. Washington,
DC.
5. Catoe H. and Nawaz Z. 2009. The Role of E6-Associated Protein in Estrogen Receptor Alpha
Protein Regulation. University of Miami’s 2009 Department of Biochemistry and Molecular
Biology Retreat. Miami, FL.
6. Pedroso I.M. and Nawaz Z. 2009. Effects of E6-AP and Hormone Induction on miRNA Expression
Levels in MCF7 Cells. 2009 Annual Sylvester Cancer Research Poster Session. Miami, FL.
7. Srinivasan S., Ismail A., Pedroso I.M., Rudd K.E., Zhou J. and Nawaz Z. 2009. Genome Wide
Analysis of Estrogen Dependent E6-AP Binding Sites in MCF-7 Breast Cancer Cells. Miami
Winter Symposium. Miami, FL.
8. Dhananjayan S., Ramoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively
Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. Cold Spring Harbor Lab,
NY.
9. Ramamoorthy S., Dhananjayan S. and Nawaz Z. 2008. E6-Associated Protein (E6-AP) Regulates
Mammary Gland Morphogenesis by Modulating the Ubiquitin-Mediated Proteolysis of the
Progesterone Receptor. Cold Spring Harbor Lab, NY.
10. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively
Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. DOD – Era of Hope
Meeting.
11. Srinivasan S., Ismail I., Rudd K.E., Zhou J. and Nawaz Z. 2008. Genome Wide Analysis of
Estrogen DependentE6-AP Binding Sites in MCF-7 Breast Cancer Cells. Endocrine Annual
Meeting.
20
12. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-associated protein (E6-AP): A potential tumor
suppressor protein. AACR Annual Meeting.
13. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2007. Oncogenic WW-domain containing
oxidoreductase negatively regulates the coactivation functions of WW-domain binding protein-2
and yes-associated protein 1. Endocrine Society Annual Meeting.
14. Ramamoorthy S., Dhananjayan S., Zafar S. and Nawaz Z. 2007. E6-Associated Protein is a Cell
Growth Regulator in Mammary gland. Endocrine Society Annual Meeting.
15. Srinivasan S., Zafar S., Nawaz Z. and Loggie B.W. 2006. Transcriptional Regulation of MUC2 by
Estrogen. ASCO GI Annual Meeting.
16. Dhananjayan S., Khan O.Y. and Nawaz Z. 2005. Identification and characterization of WW-
domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor
functions. The Endocrine Society Annual Meeting.
17. Srinivasan S., Khan O.Y., Fu G., Ismail A., Tu Y., Lu S. and Nawaz Z. 2005. Multifunction steroid
receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate
gland. The Endocrine Society Annual Meeting.
18. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme,
UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with
SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.
19. Zafar S., Gao X., Khalid M., Gatalica Z. and Nawaz Z. 2004. E6-associated protein, E6-AP is
involved in the carcinogenesis of human breast and prostate. AACR Meeting.
20. Loggie B.W., Nawaz Z., Gatalica Z., Silvaand E. and El-Ella G.A. 2003. Inhibition of
Mucin 2 production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical
Society of Oncology.
21. El Ella G.A., Gatalica Z. and Nawaz Z. 2003. Inhibition of Mucin production: Implications for
treatment of breast cancer. AACR Meeting.
22. Zafar S., Gao X., Khalid M., Gatalica Z. and Nawaz Z. 2003. E6-associated protein, E6-AP is
involved in the carcinogenesis of human breast and prostate. AACR Meeting.
23. Loggie B.W., El-Ella G.A., Gatalica Z., Silvaand E. and Nawaz Z. 2003. Promising new
strategies for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.
24. Haq R.U. and Nawaz Z. 2002. Identification and characterization of WW-domain binding proteins
as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine
Society.
25. Gao X., Mohsin S.K., Wheeler T.M., Yan F. and Nawaz Z. 2002. E6-associated protein, E6-AP,
is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine
Society.
26. Verma S., Liu Z., Haq R., O’Malley B.W. and Nawaz Z. 2002. UBCH7, an E2 ubiquitin-
comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone
Symposia.
21
27. Hopp T.A., Wang C., Pestell R.G., Nawaz Z., Wang M. and Fuqua S.A.W. 2001. A hypersensitive
mutation of estrogen receptor a occurring in premalignant breast disease influences co-activator
binding, receptor acetylation, and stability. The Endocrine Society.
28. Gao X. and Nawaz Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed
in human mammary tumors. The Endocrine Society.
29. Hopp T., Allred D.C., Hilsenbeck S., Mohsin S., Nawaz Z., O’Connell P., Pestell R.G. and Fuqua
S.A.W. 2000.
30. Barron N., Nawaz Z., Qin J. and O’Malley B.W. 2000. Effects of the Ccr4/Not complexes on
steroid receptor-dependent transcription. The Endocrine Society.
31. Dennis A., Nawaz Z. and O’Malley B.W. 2000. Characterization of UBA3: A novel type of nuclear
hormone receptor coactivator. The Endocrine Society.
32. Cox G.W., Nawaz Z. and Johnson G.V.W. 2000. Analysis of a unique nuclear transglutaminase
(TGase) substrate expressed in macrophages. American Association of Immunology Meeting.
33. Lonard D. M., Smith C.L., Nawaz Z. and O’Malley B.W. 2000. Ligand-mediated down-regulation
of estrogen receptor-alpha depends upon intact AF-2 coactivator-binding surfaces, The Key Stone
Symposia.
34. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Nawaz Z., Herrera R.E., Yee D., Brown P.H.,
Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.A.W. and Osborne K. 1999. FKHR, a novel nuclear
receptor interacting protein that functions as both a coactivator and corepresso. AACR Meeting
(The Steroid Receptor Superfamily)
35. Lonard D. M., Nawaz Z., Smith C. L. and O’Malley B. W. 1999. Involvement of ubiquitin-
proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid
Receptor Superfamily).
36. Lonard D., Nawaz Z., Smith C. L., Tsai S. Y., Tsai M.-J. and O’Malley B. W. 1998. The ubiquitin-
protein ligase E6-AP, mutated in Angelman syndrome, is a steroid receptor coactivator. The Key
Stone Symposia.
37. Nawaz Z., Lonard D., Smith C. L., Tsai S. Y. , Tsai M.-J. and O’Malley B. W. 1998. The angelman
syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The
Key Stone Symposia.
38. Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Specific mutations in the ligand binding domain
selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia,
USA.
39. Burris T.P., Nawaz Z., Tsai S.Y., Tsai M.J. and O'Malley B.W. 1995. Interaction cloning of a
protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors.
The Endocrine Society, USA.
40. Nawaz Z., Stillman D., Burris T., O'Malley B.W. and Tsai M.J. 1994. The yeast SIN3 gene
negatively regulates the transcriptional activity of the human progesterone receptor and positively
regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society, USA.
22
41. Hyder S.M., Nawaz Z. and Stancel G.M. 1993. A single base change in the flanking sequence of a
cellular oncogene creates an active estrogen response element- A possible mechanism of hormonal
carcinogenesis? The Endocrine Society, USA.
42. Nawaz Z., Tsai M.J., McDonnell D.P. and O'Malley B.W. 1992. A system to identify novel steroid
response elements. ASBMB/Biophysical Society, USA.
43. Nawaz Z., McDonnell D.P. and O'Malley B.W. 1991. A novel system to identify steroid responsive
elements. Eight Workshop on Vitamin D, Paris, France
44. Nawaz Z., Smith D.W., McDonnell D.P. and O'Malley B.W. 1991. Expression of functional
vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D, Paris, France.
Invited Oral Presentations
Nawaz, Z. 2014. New Trends in Biomedical Research Workshop. Six lectures: Mechanisms of
Bacterial Pathogenesis and Venues for Novel Therapeutics; Steroid Hormone Receptor Signaling in
Cancer and Neurological Diseases; Targeted Molecular Imaging and Drug Delivery Systems; Targeting
Cancer Stem Cells – A New Era in Tumor Therapeutics; Grant Writing; Reading and Writing a
Scientific Paper versus Poster Presentations. Center of Excellence in Molecular Biology, University of
the Punjab. Lahore, Pakistan. Nawaz, Z. 2012. The Transcriptional Coactivation Function of E6-Associated Protein in the Brain:
Novel Insights into the Pathobiology of Debilitating Neurogenetic Diseases. Scripps Florida. Jupiter, Florida, USA.
Nawaz, Z. 2010. Steroid Hormone Receptor Coactivator, E6-Associted Protein (E6-AP) Regulates
PI3K-Akt Signaling and Cell Growth. FASEB: The Physiology of Integrated Nuclear and Extranuclear Steroid Signaling, Snowmass Village, Colorado, USA.
Nawaz, Z. 2009. Tumor suppressor, WWOX1, attenuates oncogenic YAP1 and WBP-2 mediated ER
and PR transactivation functions. The HIPPO Tumor Suppressor Pathway: A Brainstorming Workshop. Rome, Italy
Nawaz, Z. 2009. E6-AP Mediated Proteolysis of PR-B Regulates Mammary Gland Tumorigenesis by
Modulating the Wnt Signaling Pathway. Endocrine Society Annual Meeting, Washington, D.C. Nawaz, Z. 2008. Regulation of Estrogen and Progesterone Receptor Coactivators by a Novel
Tumor Suppressor. University of South Florida. Tampa, Florida. Nawaz, Z. 2008. Bench to Bed: Molecular Strategies for Targeted Cancer Therapies. International Symosium on Applications of Molecular Biological Research in Health, University of Punjab, Lahore, Pakistan. Nawaz, Z. 2008. Mechanism of action of siRNAs – An Overview. International Symosium on Applications of Molecular Biological Research in Health, University of Punjab, Lahore, Pakistan. Nawaz, Z. 2007. Steroid Hormone Receptor Coactivator, E6-Associated Protein (E6-AP) Regulates PI3K-Akt Signaling and Prostate Cell Growth. AACR Annual Meeting, Los Angeles, California. Nawaz, Z. 2006. Estrogen receptor degradation: Implications in breast cancer treatment. Eli Lilly Pharmaceuticals.
23
Nawaz, Z. 2006. Determinants of estrogen receptor stability. University of Missouri, Columbia, Missouri. Nawaz, Z. 2006. Ubiquitin-proteasome pathway and gene transcription. The Pennington Biomedical Research Center, Baton Rouge, Louisiana. Nawaz, Z. 2006. Role of E6-AP in the development of prostate gland. Creighton University, Omaha, Nebraska. Nawaz, Z. 2006. Steroid hormone receptor coactivator, E6-associated protein (E6-AP) regulates P13K-Akt signaling and prostate cell growth. Baylor College of Medicine, Houston, Texas. Nawaz, Z. 2006. Novel roles of steroid receptor coactivator E6-associated protein (E6-AP) in cellular signaling. Baylor College of Medicine, Houston, Texas. Nawaz, Z. 2005. Ubiquitin-proteasome pathway enzymes police the estrogen receptor alpha-mediated gene activation. Louisiana State University. Baton Rouge, Louisiana. Nawaz, Z. 2005. Molecular determinants of estrogen receptor stability and transactivation. Pakistan. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland development. Pakistan. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland development. China. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland and mammary gland development. China. Nawaz, Z. 2004. Ubiquitin-Proteasome Pathway Enzymes act as Modulators of Steroid Hormone Receptors. Cancer Center, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama. Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with SRC-1 and E6-AP. MD Anderson. Houston, Texas. Nawaz, Z. 2003. Novel modulators of steroid hormone receptors. Biomedical Sciences. Creighton University, Omaha, Nebraska. Nawaz, Z. 2003. Ubiquitin Conjugating Enzyme, UBCH7 a coactivator for steroid hormone receptors. Endocrine Meeting. Philadelphia, Pennsylvania. Nawaz, Z. 2003. Role of the ubiquitin-proteasome pathway in nuclear hormone receptor functions. NIH. USA. Nawaz, Z. 2003. Novel coactivators of steroid hormone receotprs. IBC meeting on Nuclear Receptors as Targets for Drug Development, Philadelphia, Pennsylvania. Nawaz, Z. 2003. Steroid hormone receptor cactivators and gene transcription. Center for Advanced Molecular Biology. Lahore, Pakistan. Nawaz, Z. 2002. Steroid hormone receptor cactivators. Cancer Center, Creighton University. Omaha, Nebraska.
24
Nawaz, Z. 2002. Steroid hormone receptor coregulators. Department of Pharmacology. Texas Tech University, Amarillo, Texas. Nawaz, Z. 2002. E6-Associated Protein (E6-AP) and Steroid Hormone Receptor Functions. Department of Pharmacology and Cell Biophysics. University of Cincinnati Medical School. Cincinnati, Ohio. Nawaz, Z. 2000. Regulation of Gene Expression by the Nuclear Hormone Receptor-Coactivator
Complex Requires the Ubiquitin-Proteasome Pathway. The Endocrine Society. Nawaz, Z. 2000. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear
hormone receptor superfamily. University of North Texas. Denton, Texas.
Nawaz, Z. 1999. Impact of the ubiquitin-proteasome pathway on nuclear hormone action. Tumor
Biology Section, University of Texas, M.D. Anderson Cancer Center. Houston, Texas.
Nawaz, Z. 1999. Proteasome-dependent degradation of the human estrogen receptor. The Endocrine
Society Meeting. San Diego, California.
Nawaz, Z. 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear
hormone receptor superfamily. University of Oklahoma Health Science Center. Oklahoma City,
Oklahoma.
Nawaz, Z. 1998. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear
hormone receptor superfamily. The Endocrine Society Meeting. New Orleans, Louisiana.
Nawaz, Z. 1997. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear
hormone receptor superfamily. Baylor College of Medicine. Houston, Texas.
Nawaz, Z. 1997. A novel host system to study steroid hormone receptor action. Nuclear Institute of
Biotechnology and Genetic Engineering (NIBGE). Faisalabad, Pakistan
Nawaz, Z. 1997. A novel host system to study steroid hormone receptor action. National Institute of
Biotechnology and Genetic Engineering. Faisalabad, Pakistan.
Nawaz, Z. 1996. Mechanism of gene silencing by thyroid hormone receptor. University of Texas
Health Science Center at San Antonio. San Antonio, Texas.
Nawaz, Z. 1995. Molecular mechanism of gene silencing by thyroid hormone receptor. Baylor College
of Medicine. Houston, Texas.
Nawaz, Z. 1995. Molecular mechanism of action of steroid hormone receptors. University of North
Texas. Denton, Texas.
Nawaz, Z. 1994. The yeast SIN3 gene negatively regulates the transcriptional activity of the human
progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. Proc.
76th Ann Mtg Endocrine Soc. Anaheim, California.
Nawaz, Z. 1993. Cloning of steroid hormone receptors in yeast (Saccharomyces cerevisiae). University
of North Texas. Denton, Texas.
25
Patents Applied
1. Use of “Pure” Antiestrogen Synthetic Steroids to Inhibit Progestin-Induced Transcription and
Method for Administrating Same to Humans and Animals; No. 60/090,074; G&S No. 25630/04
(2004)
2. Novel Coactivator Overexpressed in Endocrine Tumors; OTA# 98-83; P-01750 (2002)
3. Production of antibodies against a novel coactivator, E6-associated protein (E6-AP). (2001)
4. siRNAs mediated reduction of expression of mucin proteins in neoplasms. (2003)
5. Development of New Therapeutic Agents for the Treatment of Breast Cancer. (2003)
Courses and Workshops Attended
Thirteenth Annual Molecular Endocrine Workshop, USA (1999)
Eight Workshop on Vitamin D, Paris, France (1991)
The ASBMB/Biophysical Society Workshop, USA (1992)
The Forty-sixth Annual Symposium on Fundamental Cancer Research, USA (1998)
The Welch Foundation Conference on Chemical research, USA (1990)
The Endocrine Society Annual Meeting, USA (1993-Present)
The Key Stone Symposium, USA (1998-Present)
Study Sections
1. Department of Veterans Affairs (1999-2002)
2. PA DOH CURE Program (2000-2009)
3. US Army Prostate Cancer Research Program (2001-2002)
4. US Army Breast Cancer Research Program (2002-2009)
5. NIH (2006)
6. Texas A&M University, Center for Environmental and Rural Health, Pilot Project Grant
Application (2006)
7. University of Missouri Seed Grants (2007)
8. NIH Molecular and Cellular Endocrinology [MCE] (2010)
9. US Army Prostate Cancer Research Program [USAMRMC/CDMRP] (2010-Present)
10. DoD/CDMRP Breast Cancer Research Program Idea Award/Chair, Study Section (2012)
VI. TEACHING
BMB Graduate Program Director (2009 – 2012)
Director dual BS/PhD Program (2011-Present)
Mentoring Junior Faculty
o KO1 Awards
Dr. Elizabeth Floyd, PBRC, Louisiana State University
Dr. Prema Rampuri, Creighton University
o Komen Catalyst
Dr. Seema Gupta, Department of Radiation Oncology, University of
Miami/Sylvester Comprehensive Cancer Center
Post Doctoral Fellows
o Mentor/Co-PI on Post Doctoral Fellow UM/SCCC Braman Family Breast Cancer
Institute Training Grant - “Training in Translational Breast Cancer Research”
26
Graduate Teaching
o Regulation of Eukaryotic Gene Transcription – BMB610, Department of
Biochemistry & Molecular Biology, UM Miller School of Medicine
o Advanced Biochemistry & Molecular Biology – BMB609, Department of
Biochemistry & Molecular Biology, UM Miller School of Medicine
o Journal Club – BMB601, Department of Biochemistry & Molecular Biology, UM
Miller School of Medicine
o Scientific Reasoning and Logic in Clinical Cancer Biology – CAB 602, Cancer
Biology, UM Miller School of Medicine/SCCC
o Colloquia in Clinical Cancer Research – CAB 630, Cancer Biology, UM Miller
School of Medicine/SCCC
o Seminar in Cell & Molecular Biology – 242-466
o Readings – 242-548
Medical School Teaching
o MBL Module
Carbohydrate Metabolism (11 lectures per year)
Energy and Carbohydrate Metabolism and Their Regulation 1
Essential Requirements for Metabolism/Factors that Regulate
Metabolism
Digestion and Absorption of Carbohydrates and Proteins
Glycolysis
Pentose Phosphate Pathway/Pyruvate Dehydrogenase Complex
Citric Acid Cycle/Electron Transport Chain
Ketosis, Roles of Other Carbohydrates
Glycogenesis/Glycogenolysis/Glycogen Storage Disease
Glucose/Membrane Transport/Signal Transduction
Glucose Homeostasis Introduction/Gluconeogenesis
Integration of Metabolism
Undergraduate and Summer Students
Past
o Naomi Desrosiers (Summer 2012)
o Raj Parikh (Summer 2012)
o Rhiya Mittal (Summer 2012)
o Alexander Garcia (Fall 2011)
o Michelot Michel (Summer 2011)
o Obianuju Akaniru (Summer 2011)
o Jean-Pierre Obeid (Summer 2011)
o Jude Chan (Summer 2011)
o Ilona Juan (Summer 2009)
o Shannon Hahn (Summer 2008)
o Courtney Griffiths (Spring/Summer 2008)
o Ali Abbas (Spring 2008)
o Najia Hamid (Summer/Fall 2007)
o Mahera Anjum (Summer 2007)
o Nitin Aggarwal (Spring 2007)
27
o Monica Gonzalez (Fall 2006)
o Sumit Jain (Fall 2006)
o Leticia A. Polite (Summer 2006)
o Adante Hart (Summer 2006)
Current Medical Students
Jennifer McLeod (2012)
Current Graduate Students
Celeste Amadei (2015)
Kelsey Moody (2014)
Current Postdoctoral Fellows
Jimmy El Hokayem (2013)
Laura Buffa (2010)
Rozina Tufail (2008)
Ph.D. Thesis Advisor
Patricia Boothe (2010)
Heath Catoe (2006-2010)
Sivapriya Ramamoorthy (2004-2009)
Sathish Srinivasan (2004-2009)
Sarath Dhananjayan (2003-2007)
Andrew Dennis (1999-2004)
Virginia Pearce (1997-2002)
Ph.D. Thesis Committees
Ankita Thakkar (2013-Present)
Ashley Melchior (2011-2012)
Amy Plotkin (2010-2014)
Cale Fahrenholtz (2010-2014)
Nirav Patel (2010-2014)
Wensi Tao (2010-Present)
Ali Saeed (2009-2011)
Jimmy El Hokayem (2009-2013)
Diana Azzam (2009-2012)
Fangfang Lai (2009-2012)
Melvys Valledor Ceballos (2009-2011)
Salil Sharma (2008-2011)
Jeffim Kuznetsov (2008-2012)
Qiuping Ma (2008 External Comm. Chair)
Kevin Curtis (2007-2010)
Megan Rieger (2007-2010)
Kenneth Seldeen (2007-2009)
Iliana Soto (2007-2011)
28
Sophia Kyriacou (2006-2008)
Heath Catoe (2006-2010)
Shuyun Rao (2005-2009)
Names of
Mentor &
Trainees
(include training
level)
Training
Period Degree(s) Prior to Entering Training
Title of Research Project
While Training with this Mentor
Type(s)
Award
Date(s)
Awarding
Institution
Z. Nawaz /
Kibeom Jang
(pre)
2012 - 2013 MS 2010
Hanyang
University, S.
Korea
Mechanisms whereby Src activates
estrogen stimulated ER proteolysis
and ER target gene expression
Z. Nawaz /
Patricia Boothe
(pre)
2010
MUC4, the Integral Membrane
Modulator of ERBB2: The Effects
of MUC4 Expression on ERBB2 &
ERBB3 Phosphorylation, Receptor
Levels and Sub-Cellular
Localization in Breast Cancer Cells
Treated with Neuregulin
Z. Nawaz /
Jimmy El
Hokayem
(pre)
2009 -
2013 M.S. 8/2007
American
University of
Beirut
Role of the Coactivation Function
of E6AP and ER in Angelman
Syndrome Pathogenesis
Z. Nawaz /
Ali Saeed
(pre)
2009 -
2011 B.S. 5/2005
University of
Miami,
Florida
The Role of WBP1 in Steroid
Hormone Receptor Regulation
Z. Nawaz /
Heath Catoe
(pre)
2006 -
2010 B.S. 5/2004
University of
South Carolina,
Columbia
Role of E6-AP in Estrogen Receptor
Alpha Functional Modulation
Z. Nawaz /
Sivapriya
Ramamoorthy
(pre)
2004 -
2009 M.S. 8/2001
Bharathidasam
University
Role of E6-AP in Mammary
Gland Development and Breast
Carcinogenesis
Z. Nawaz /
Sathish
Srinivasan
(pre)
2004 -
2009 M.S. 8/2001
Birla Institute of
Technology and
Science
Role of E6-AP in Prostate Gland
Development and Carcinogenesis
Z. Nawaz /
Sarath
Dhananjayan
(pre)
2003 -
2007 M.S. 8/2001
Bharathidasam
University
Role of WBP-2 in Steroid Hormone
Receptor Function and Breast
Carcinogenesis
Z. Nawaz /
Andrew Dennis
(pre)
1999 -
2004 Ph.D. 12/2004
Baylor College
of Medicine
Function of Protein Degradation
by 26S Proteasome During
Progesterone Receptor
Dependent Transcription
29
Z. Nawaz /
Virginia Pearce
(pre)
1997 -
2002 Ph.D. 6/1997
University of
North Texas
Isolation and Characterization of
New Phytoestrogen(s) That
Modulate Human Estrogen
Receptor Activity
Z. Nawaz /
Jimmy El
Hokayem
(post)
2013 -
Present Ph.D. 4/2013
University of
Miami
“E6-AP transcriptional targets in the
pathogenesis and therapy of AS”
Z. Nawaz /
Laura Buffa
(post)
2010 -
Present Ph.D. 2/2007
IMPRS,
Dresden,
Germany
Role of E6-Associated Protein, E6-
AP in the regulation of estrogen
receptor turnover and functions
Z. Nawaz /
Kosalai
Kaliappan
(post)
2009 -
2012 Ph.D. 2009
ICGEB, New
Delhi, INDIA
Mechanisms whereby Src activates
estrogen stimulated ER proteolysis
and ER target
Z. Nawaz /
Rozina Tufail
(post)
2008 -
Present Ph.D. 2003
University of
Punjab
Pakistan
Genome Wide Analysis of
Estrogen-Dependent E6-Associated
Protein Binding Sites in MCF-7
Breast Cancer Cells
Z. Nawaz /
Sathish
Srinivasan
(post)
2009 -
2010 Ph.D. 11/2009
University of
Miami
Roles of Novel Protein Complexes
in Estrogen and Progesterone
Receptor Signaling
Z. Nawaz /
Ilene Pedroso
(post)
2008 -
2009 Ph.D. 2007
University of
Miami
Role of E6-associated protein in the
Development of Tamoxifen
Resistant Breast Cancer
Z. Nawaz /
Sarath
Dhananjayan
(post)
2008 -
2009 Ph.D. 2007
University of
Miami
Role of WBP-2 in Steroid Hormone
Receptor Function and Breast
Carcinogenesis
Z. Nawaz /
Ayesha Ismail
(post)
2003 -
2007 Ph.D. 12/1999
National
Institute of
Nutrition, India
Role of the Ubiquitin-Proteasome
Pathway in Breast Carcinogenesis
Z. Nawaz /
Guilian Fu
(post)
2003 -
2007 M.D. 8/1980
Julin Medical
College
Role of E6-AP in Prostate Gland
Development and Carcinogenesis
Z. Nawaz /
Obaid Y. Khan
(post)
2002 -
2004 Ph.D. 5/1998
University of
Glasgow
Role of E6-AP in Prostate Gland
Development
Z. Nawaz /
Seema Verma
(post)
2001 -
2003 Ph.D. 2000
University of
Punjab
Characterization of UbcH7 as a
Coactivator for Steroid
Hormone Receptors.
Z. Nawaz /
Minawar Sattar
(post)
2001 -
2002 Ph.D. 12/2000 Texas A&M
Role of E6-AP in the Development
of Normal Prostate Gland and
Prostate Gland Cancer
30
Z. Nawaz /
Riaz-ul-Haq
(post)
2000 -
2002 Ph.D. 1996
University of
Punjab
Role of the Ubiquitin-Proteasome
Pathway in Nuclear Hormone
Receptor Function
Z. Nawaz /
Xiuhual Gao
(post)
1999 -
2004 Ph.D. 9/1993
Torai
University,
Japan
Role of E6-AP in Breast
Carcinogenesis
VII. SERVICE:
Committees and Administrative Responsibilities:
Administrative:
BMB Graduate Program Director, 2009-2012
Director Dual BS/PhD Program, 2011-2012 (Developed and received the approval of the program)
Associate Research Director of the Braman Family Breast Cancer Institute/ SCCC, Miami, Florida,
2004-Present.
Committees:
CAB Steering Committee, 2008-Present
Member of PIBS Curriculum Committee for the Umbrella Program, University of Miami, 2008-
2012
UM/Sylvester Lymphoma Research Career Development Grant Reviewer, 2008.
Member of IBS Curriculum Committee, University of Miami, 2007-Present.
UM/Sylvester Pap Corps Developmental Cancer Research Grant Reviewer, 2007-Present.
Member ACS Institutional Grant Review Committee, University of Miami School of Medicine,
2006-Present.
Braman Developmental Grants Program Director, 2005-Present
Member SCCC Scientific Steering Committee, University of Miami School of Medicine, 2005-
Present.
Member SAC Committee, University of Miami School of Medicine, 2005-2008.
American Cancer Society Grant Reviewer, 2008.
Member COBRE, Pennington Biomedical Research Center LA, 2006-Present.
NIH Molecular and Cellular Endocrinology [MCE] Grant Reviewer, 2006-2008
NIH Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] Grant Reviewer,
2006.
DOD Breast Cancer Research Program [BCRP] Grant Reviewer, 2002-2006.
DOD Prostate Cancer Research Program Grant Reviewer, 2002.
New Graduate Degree Programs:
In the process of developing proposals and approval of following new graduate programs:
1. MS Degree Program in Biochemistry and Molecular Biology
2. Executive MS Degree Program in Biochemistry and Molecular Biology
a. Approved and implemented Fall 2013
3. Executive PhD Degree Program in Biochemistry and Molecular Biology
a. Approved and implemented Spring 2014