CURRICULUM VITAE - Universiti Putra Malaysia2 spp3561 endocrine system - pharmacology nur 3102/...
Transcript of CURRICULUM VITAE - Universiti Putra Malaysia2 spp3561 endocrine system - pharmacology nur 3102/...
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CURRICULUM VITAE
Personal Particulars
Name : PROF. DR. JOHNSON STANSLAS Unit/Department : Pharmacotherapeutics Unit, Department of Medicine Faculty : Faculty of Medicine and Health Sciences Field of Specialisation : Pharmacology and Therapeutics Cancer Research (Cancer Pharmacology)
Drug Discovery and Development Contact number : Office : 03-89472310 Fax: 03-89472759 E-mail : [email protected]; [email protected] Membership of Professional Organisations
American Society for Pharmacology and Experimental Therapeutics (ASPET)
American Association for Cancer Research (AACR)
British Association for Cancer Research (BACR)
European Association for Cancer Research (EACR)
Malaysian Oncological Society (MOS)
Malaysian Society for Neuroscience (MSN)
Malaysian Society for Music in Medicine (MSMM)
Education and Academic Qualifications BSc (Hons), Faculty of Life Sciences, National University of Malaysia (UKM); MSc (Anticancer Research), Faculty of Life Sciences, National University of Malaysia (UKM); PhD (Cancer Pharmacology), School of Pharmacy, The University of Nottingham, United Kingdom Teaching experience Teaching activities
Code and Name of Courses
BMS 5021/6021 MOLECULAR PHARMACOLOGY
SPP3271 GENERAL AND BIOCHEMICAL PHARMACOLOGY
SPP3531 CARDIOVASCULAR SYSTEM - PHARMACOLOGY
SPP3521 URINARY SYSTEM - PHARMACOLOGY
SPP3581 CENTRAL NERVOUS SYSTEM - PHARMACOLOGY
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SPP3561 ENDOCRINE SYSTEM - PHARMACOLOGY
NUR 3102/ BASIC BIOCHEMISTRY AND PHARMACOLOGY
YEAR 3 MD PROGRAMME - INTRODUCTORY MEDICINE - PHARMACOLOGY
MASTER OF PSYCHIARTY - NEUROPHARMACOKINETICS
MEDICAL NEUROSCIENCES - NEUROPHARMACOLOGY
BMS 3040 PHARMACOLOGY
BMS 3150 TOXICOLOGY
BMS 3020 BASIC MEDICAL BIOCHEMISTRY
BMS 3021 CLINICAL BIOCHEMISTRY
SPP3211 CELLS AND TISSUES
SPP3231 MOLECULAR BASIS OF MEDICINE I
SPP3232 MOLECULAR BASIS OF MEDICINE II
SPP3231 MOLECULAR BASIS OF MEDICINE
SPP3231 MOLECULAR BASIS OF MEDICINE
SPP3233 MOLECULAR MEDICINE
PSK5905 SPECIAL TOPICS
SPS6903 SEMINAR PROPOSAL PRESENTATION
SPP3591 PROBLEM BASED LEARNING I
SPP3591 PROBLEM BASED LEARNING II
Invited lectures
International Union of Basic and Clinical Pharmacology (IUPHAR) World Conference on the Pharmacology of Natural and Traditional Medicine “Targeting K-Ras with Semisynthetic Andrographolide Derivatives: A Valid Approach in the Discovery of Potential Anticancer Drug Leads”, National University of Singapore, 22-24 July 2015.
Invited lecture at School of Biomolecular Science, School of Pharmacy, University of Nottingham, “Exploring Malaysian Biodiversity: A Rich Source of Natural Drug Prototypes”, United Kingdom, 16th December 2011.
Seminar on Computer Aided Drug Design Organised by School of Pharmaceutical Sciences, USM & Malaysian Institute of Pharmaceutical and Nutraceutical (IPHARM) – 2-8 December 2010
1st Malaysian Biotechnology Seminar ‘Evaluation of New Andrographolide Derivatives for Inhibitory Activities against Tumour Vasculature and Metastasis’ - 24 – 26 May 2010
UK-Malaysia Symposium On Drug Discovery And Development For Cancer Organised by Cancer Research Initiatives (CARIF) ‘Andrographolide, a Versatile Template in the Synthesis of Tumour-Selective and Potent Anticancer Agents’ - 24-25 February 2010
Indonesian Natural Products Conference 2009 – Plenary Lecture ‘A Decade of Research on Andrographis Paniculata: The Story So Far’
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Andalas University, West Sumatra, Indonesia, Department of Pharmacy, “Discovery and Development of Anticancer Agents: Incorporating the Experience of the Cancer Research and Drug Discovery Group of UPM”, August 2007.
Universiti Technology MARA (UiTM), Malaysia; Faculty of Pharmacy, “Current Advances in Antineoplastic Research”, March 2008.
Malaysian Oncological Society Meeting, Sabah 2008: Symposium Lectures
1. New Drug Discoveries 2. Translational Research in Oncology (TRiO) in Malaysia: the way forward
Discovery and Development of Natural and Synthetic Anticancer Agents. International Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC, Kuala Lumpur
Publications
a. Cited Journals
1. Tan, S.F, Masoumi, H.R.F., Karjiban, R.A., Stanslas J., Kirby, B.P., Basri, M., Basri, H (2016) Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability. Ultrasonics Sonochemistry 29 (2016) 299–308. 2. Daood, G.S., Basri, H., Stanslas, J., Masoumi, H.R.F and Basri, M (2015) Predicting the optimum compositions of a parenteral nanoemulsion system loaded with azithromycin antibiotic utilizing the artificial neural network model. RSC Advances. 5, 82654–82665. 3. Tan SL, Stanslas J, Basri M, Abedi Karjiban RA, Kirby B, Sani D, Basri HB (2015) Nanoemulsion-based parenteral drug delivery system of carbamazepine: Preparation, characterization, stability evaluation and blood-brain pharmacokinetics. Current Drug Delivery Sep 1. 4. Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015). Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line. International Journal of Pharmaceutical Sciences Review and Research, 32(2):166–168. 5. Wahyuni, F.S., Shaari, K., Stanslas, J., Hj. Lajis, N., Dachriyanus. (2015). Cytotoxic xanthones from the stem bark of Garcinia cowa Roxb. Journal of Chemical and Pharmaceutical Research, 7(1): 227-236. 6. Wahyuni, F.S., Stanslas, J., Lajis, N.H., Dachriyanus. (2015) Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3): 60-63. 7. Wahyuni, F.S., Shaari, K., Stanslas, J., Lajis, N., Hamidi, D. (2015) Cytotoxic compounds from the leaves of Garcinia cowa Roxb. Journal of Applied Pharmaceutical Science, 5 (2): 006-011.
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8. Lim, J.C.W., Jeyaraj, E.J., Sagineedu, S.R., Wong, W.S.F., Stanslas, J. (2015). SRS06, a New Semisynthetic Andrographolide Derivative with Improved Anticancer Potency and Selectivity, Inhibits Nuclear Factor-κB Nuclear Binding in the A549 Non-Small Cell Lung Cancer Cell Line. Pharmacology, 95: 70-77. [IF = 2.093]@; citations – 4 Quartile ranking: Q3 9. Wong C.C., Sagineedu S.R., Sumon S.H., Sidik M.S., Phillips R., Lajis N.H., Stanslas J. (2014). NCI In Vitro and In Silico Anticancer Screen, Cell Cycle Pertubation and Apoptosis-Inducing Potential of New Acylated, Benzylidene and Isopropylidene Derivatives of Andrographolide. Environmental Toxicology and Pharmacology, 38(2): 489–501 [IF = 2.093]@; citations – 3 Quartile ranking: Q2. 10. Wong H.C., Wong C.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas, J. (2014). SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells. Cell Biology and Toxicology, DOI: 10.1007/s10565-014-9282-5. [IF = 2.067]@; citations – 0 Quartile ranking: Q3. 11. Wong C.C., Periasamy, N., Sagineedu, S.R., Sidik, S., Sumon, S.H., Loadman, P., Phillips, R., Lajis, L.H., Stanslas, J. (2014). In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog. Investigational New Drugs, DOI: 10.1007/s10637-014-0105-6. [IF = 2.801]@; citations – 0 Quartile ranking: Q2. 12. Moyeenul Huq, A. K. M., Jamal, J.A., Stanslas, J. (2014). Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre. Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 782830, 11 pages. [IF = 2.286]@; citations – 0 Quartile ranking: Q2. 13. Chew YL, Lim YY, Stanslas J, Ee GCL, Goh JK. (2014) Bioactivity-guided Isolation of Anticancer Agents from Hauhinia Kockiana Korth. African Journal of Traditional Complementary Alternative Medicine. 11(3):291-299. [IF = 0.951]@ citations – 0 Quartile ranking: Q4. 14. Ashraf, M.F., Abd Aziz, M., Stanslas, J., Ismail, I., Abdul Kadir, M. (2013). Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of chlorophytum borivilianum. The Scientific World Journal 2013: 216894. citations – 1 Quartile ranking: Q2. 15. Nasir, N.M., Rahmani, M., Shaari, K., Kassim, N.K., Go, R., Stanslas, J., Jeyaraj, E.J. (2013). Xanthones from Calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana 42(9): 1261-1266. citations – 0 Quartile ranking: Q3. 16. Abdul Latip A.F., Hussein M.Z., Stanslas J., Wong C.C., Adnan R (2013). Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound. Chemistry Central Journal 7(1): 119. [IF = 2.071]@; citations – 0 Quartile ranking: Q2. 17. Ashraf M.F., Aziz M.A., Kadir M.A., Stanslas J., Farokhian E. (2013). In Vitro Tuberization of Chlorophytum Borivilianum Sant & Fern (Safed Musli) As Influenced by Sucrose, CCC and Culture Systems. Plant and Cell Physiology 54(8): 1356-1364. [IF = 4.972]@; citations – 0 Quartile ranking: Q1.
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18. Hocker H.J., Cho H.J., Chen C.Y.K., Maharaj N., Wong C.C., Wong H.C., Sagineedu S.R., Shaari K., Stanslas J., Hancock J.F., Gorfe A.A. (2013). Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function. Proceedings of the National Academy of Sciences of USA 110(25): 10201-10206. [IF = 10.727]@; citations – 34 Quartile ranking: Q1. 19. Hasan S., Basri H.B., Hin L.P., Stanslas J. (2013). Encephalitis followed by optic neuritis: A case report and review of literature. Pakistan Journal of Medical Sciences 29(3):859-862. [IF = 0.156]@; citations – 0 Quartile ranking: Q4. 20. Al-Mekhlafi N.A., Shaari K., Abas F., Jeyaraj E.J., Khallivulla S.I., Stanslas J., Lajis N.H. (2013). New Flavan and Alkyl α,β-Lactones from the Stem Bark of Horsfieldia superba. Natural Products Communication 8(4): 447-451. [IF = 0.956]@; citations – 1 Quartile ranking: Q4. 21. Wong M.S., Sidik S.M., Mahmud R., Stanslas J. (2013). Molecular targets in the discovery and development of novel antimetastatic agents: Current progress and future prospects. Clinical Experimental Pharmacology and Physiology 40(5):307-1. [IF = 2.067]@; citations – 8 Quartile ranking: Q2. 22. Ashraf M.F., Aziz M.A., Stanslas J., Kadir M.A. (2013). Optimization of immersion frequency and medium substitution on microtuberization of Chlorophytum borivilianum in RITA system on production of saponins. Process Biochemistry, 48(1): 73-77. [IF = 2.922]@; citations – 2 Quartile ranking: Q1. 23. Ooi C.T., Syahida A., Stanslas J., Maziah M. (2013). Efficiency of different Agrobacterium rhizogenes strains on hairy roots induction in Solanum mammosum. World Journal of Microbiology and Biotechnology, 29: 421-430. citations – 2 24. Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2013). Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the asian population requires special attention. International Journal of Neurosciences. 123(3): 143-154. [IF = 0.967]@; citations – 5 Quartile ranking: Q4. 25. Saha K., Lam S.K., Abas F, Hamzah A.S., Stanslas J., Lim S.H., Lajis N.H. (2012). Synthesis of damnacanthal, a naturally occuring 9,10-anthraquinone and its analogues, and its biological evaluation againt five cancer cell lines. Medicinal Chemistry Research 22(5): 2093-2104. [IF = 1.612]@; citations – 3 Quartile ranking: Q3. 26. Jabir R.S., Naidu R., Azrif A.A., Ho G.F., Munisamy M., Stanslas J. (2012). Pharmacogenetics of Taxanes: Impact of Gene Polymorphisms of Drug Transporters on Pharmacokinetics and Toxicity. Pharmacogenomics, 13(16): 1979-1988.[IF = 3.439]@; citations – 4; Quartile ranking: Q1; #CA 27. Jamal J.A., Ramli N., Stanslas J., Husain K. (2012). Estrogenic activity of selected Myrsinaceae species in MCF-7 human breast cancer cells. International Journal of Pharmacy and Pharmaceutical Sciences, 4, Suppl 4: 547-553. Scopus indexed; citations – 2; *CAU. 28. Hasan M.S., Stanslas J., Lim P.H., Basri H.B. (2012). A young lady with thalamic stroke mimicking acute Miller Fisher syndrome. Neurosciences, 17(4): 7-8. [IF = 0.121 ]@; citations – 0; Quartile ranking: Q4
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29. Al-Mekhlafi N.A., Shaari K., Abas F., Kneer R., Jeyaraj E.J., Stanslas J., Yamamoto N., Honda T., Lajis N.H. (2012). Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila. Phytochemistry, 80: 34-49. [IF = 3.571]; citations – 4; Quartile ranking: Q1 30. Lim C.W., Chan T.K., Ng S.W.D., Sagineedu S.R., ^Stanslas J., ^Wong W.S.F. (2012). Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clinical and Experimental Pharmacology and Physiology, 39(3): 300-310. [IF = 2.067]; citations – 48; Quartile ranking: Q2; *CAU (^ - equal contribution). 31. Hasan MS, Basri H.B., Lim P.H., Stanslas J. (2011). Surgical remotion of a cysticercotic granuloma responsible for refractory seizures: A case report. Surgical Neurology International, 2:177 ; citations – 1 32. Shaari K., Suppaiah V., Wai L.K., Stanslas J., Tejo B.A., Israf D.A., Abas F., Ismail I.S., Shuaib N.H., Zareen S., Lajis N.H. (2011). Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelifolia and molecular insights into its interaction with 5-lipoxygenase. Bioorganic & Medicinal Chemistry, 19(21): 6340-6347. [IF = 3.205]; citations – 3; Quartile ranking: Q2 33. Chew Y.L., Chan E.W.L., Tan P.L., Lim Y.Y., Stanslas J., Goh J.K. (2011). Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia. BMC Complementary and Alternative Medicine, 11:12. [IF = 2.343]; citations – 17; Quartile ranking: Q1; *CAU 34. Wong H.C., Sagineedu S.R., Lajis N.H., Loke S.C. and Stanslas J. (2011). Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells. African Journal of Pharmacy and Pharmacology, 5(2): 225-233. [IF = 0.875]; citations – 3; Quartile ranking: Q4; #CA 35. Bagalkotkar G., Tang S.C., Khalivulla S.I., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. and Stanslas J. (2011). Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Müll. Arg. (Euphorbiaceae). African Journal of Pharmacy and Pharmacology, 5(2): 183-188. [IF = 0.875]; citations – 4; Quartile ranking: Q4; #CA 36. Nobakht G.M., Kadir A.M., Stanslas J. (2010). Analysis of preliminary phytochemical screening of Typhonium flagelliforme. African Journal of Biotechnology, 9 (11): 1655-1657. [IF = 0.574]@; citations – 2; Quartile ranking: Q4. 37. Sulaiman M.R., Zakaria Z.A., Abdul Rahman A., Mohamad A.S., Desa M.N., Stanslas J., Moin S., Israf D.A. (2010). Antinociceptive and Antiedematogenic Activities of Andrographolide Isolated From Andrographis paniculata in Animal Models. Biological Research for Nursing, 11 (3): 293-301. [IF = 1.385]; citations – 14; Quartile ranking: Q1 38. Nobakht G.M., Kadir A.M., Stanslas J. (2009). In vitro mass propagation of Typhonium flagelliforme as affected by plant growth regulators. African Journal of Biotechnology, 8 (24): 6840-6843. [IF = 0.574]@; citations – 1; Quartile ranking: Q3
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39. Maulidiani, Shaari K., Paetz C., Stanslas J., Abas F., Lajis N.H. (2009). Naturally occurring labdane diterpene and benzofuran from Globba pendula. Natural Product Communications, 4(8):1031-1036. [IF = 1.019]; citations – 1; Quartile ranking: Q2. 40. Vasudevan R., Ismail P., Stanslas J., and Shamsudin N. (2009). Analysis of three genetic polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. African Journal of Biotechnology, 8(10): 2069-2075. [IF = 0.574]@; citations – 2; Quartile ranking: Q3. 41. Ramachandran V., Ismail P., Stanslas J., Shamsudin N. (2009). Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. Cardiovascular Diabetology, 8:11. [IF =3.521]; citations – 11; Quartile ranking: Q2. 42. Jabit M.L., Wahyuni F.S., Khalid R., Israf D. A., Shaari K., Lajis N.H. and Stanslas J. (2009). Cytotoxic and Nitric Oxide Inhibitory Activities of Methanol Extracts of Garcinia Species. Pharmaceutical Biology, 47(11): 1019-1026.[IF =1.1856]; citations – 7; Quartile ranking: Q3; #CA
43. Manikam S.D., and Stanslas J. (2009). Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis. Journal of Pharmacy and Pharmacology, 51, 69-78. [IF = 2.326]; citations – 19; Quartile ranking: Q3; #CA
44. Ahamed M.E., Ahmed M.E., Eltoum A.M., Altahir G.O., Ahmed K.M., Harbi S.O., Stanslas J., and Mohamed A.O. (2008). Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients. European Journal of Inflammation, 6:115-121. [IF = 0.990]@; citations – 3; Quartile ranking: Q4. *CAU
45. Nor Aini A.S., Merrina A., Stanslas J. and Sreeramanan S. (2008). Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4(3): 103-109; citations – 0;
46. Jada S.R., Matthews C., Saad M.S., Hamzah A.S., Lajis N.H., Stevens M.F.G. and Stanslas J. (2008). Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis. British Journal of Pharmacology, 155(5):641-654. [IF = 4.994]@; citations – 31; Quartile ranking: Q1; #CA
47. Vasudevan R., Ismail P., Stanslas J., Shamsudin N. (2008). Association of G2350A polymorphism of angiotensin converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. Journal of Biological Sciences. 8(6): 1045-1050. citations – 7;
48. Vasudevan R., Ismail P., Stanslas J., Shamsudin N., and Ali A.B. (2008). Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. International Journal of Biological Sciences, 4(6):362-367. [IF = 4.223]@; citations – 7; Quartile ranking: Q1 49. Vasudevan R., Ismail P., Stanslas J., Shamsudin N., Moin S. and Jas R.M. (2008). Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. Journal of the Renin-Angiotensin-Aldosterone System, 9(4):208-214. [IF = 2.000]; citations – 16; Quartile ranking: Q3.
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50. Muniandy S.V., and Stanslas J. (2008). Modelling of chromatin morphologies in breast cancer cells undergoing apoptosis using generalized Cauchy field. Computerized Medical Imaging and Graphics, 32(7):631-637. [IF = 1.707]; citations – 12; Quartile ranking: Q3; *CAU 51. Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). C-511T polymorphism of interleukin-1 b gene is not associated in type 2 diabetes mellitus – a study in Malaysian population. Journal of Medical Sciences, 8(3):216-221; citations – 1; 52. Vasudevan R., Ismail P., Stanslas J. and Shamsudin N. (2008). No association of BgII dimorphism in human renin gene in hypertensive subjects in Malaysia. Research Journal of Biological Sciences, 3(10):1218-1222; citations – 0; 53. Jabit M. L., Khalid R., Abas F., Shaari K., Hui L. S., Stanslas J., and Lajis N. H. (2007). Cytotoxic xanthones from Garcinia penangiana Pierre. Z. Naturforsch, 62c: 786-792. [IF = 0.776] citations – 7; Quartile ranking: Q4 54. Khalid R. M., Jabit M. L., Abas F., Stanslas J., Shaari K., and Lajis N. H. (2007). Cytotoxic Xanthones from the Leaves of Garcinia urophylla. Natural Product Communication. 2(3), 271-276. [IF = 1.019] citations – 7; Quartile ranking: Q2 55. Wijayahadi N., Haron M. R., Stanslas J., Yusuf Z. (2007). Changes in Cellular Immunity during Chemotherapy for Primary Breast Cancer with Anthracycline Regimens. Journal of Chemotherapy. 19, 716- 723. [IF = 0.969]; citations – 10; Quartile ranking: Q4; *CAU. 56. Jada S.R., Subur G.S., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J. (2007). Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry, 68: 904-912. [IF = 3.571]; citations – 77; Quartile ranking: Q1; #CA. 57. Sagineedu S.R., Ng S-L., Razak I.A., Fun H-K., Lajis N.H. and Stanslas J. (2006). 3,19-(2,6-dimethoxybenzyledine)andrographolide. Acta Crystallography. E62: o5806-o5808. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA
58. Abas F., Lim S.H., Ahmad S., Shaar, K., Stanslas J., Israf D.A., Lajis N.H. (2006). Biological Evaluation of Curcumin and Related Diarylheptanoids. Z. Naturforsch, 61c: 625-631. [IF = 0.776]; citations – 10; Quartile ranking: Q4 59. Bagalkotkar G., Sagineedu S.R., Saad M.S. and Stanslas J. (2006). Phytochemicals from Phyllanthus niruri and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58 (12): 1559-1570. [IF = 2.326]; citations – 63; Quartile ranking: Q2; #CA 60. Jada S.R., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F. and Stanslas J. (2006). Semisynthesis and cytotoxic activities of andrographolide analogues. Journal of Enzyme Inhibition and Medicinal Chemistry, 21(2): 145-155. [IF = 1.815]; citations – 27; Quartile ranking: Q3; corresponding #CA 61. Jada S.R., McMillan K., Hamzah A.S., Saad M.S., Lajis N.H., Stevens M.F.G., Schwalbe C.H. and Stanslas J. (2006). 14-acetylandrographolide. Journal of Chemical Crystallography, 36(2):93-97. [IF = 0.488]; citations – 2; Quartile ranking: Q4; #CA
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62. Ng S-L., Sagineedu S.R., Razak I.A., Fun H-K, Jada S.R. and Stanslas J., (2006). 3,19-(2-bromobenzyledine)andrographolide. Acta Crystallography. E62: o592-o594. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA 63. Teh B-J., Sagineedu S,R., Fun H-K., Razak I.A., Lajis N.H. and Stanslas J. (2006). 14-Deoxy-11,12-didehydro-3,19-isopropyledineandrographolide. Acta Cryst. E62: o589-o591. [IF = 0.499]; citations – 1; Quartile ranking: Q4; #CA 64. Abas F., Lajis N.H., Shaari K., Israf D.A., Stanslas J., Yusuf U.K., and Raof S.M. (2005). A New Labdane Diterpene Glucoside from the Rhizomes of Curcuma mangga. Journal of Natural Products, 68: 1090-1093. [IF = 3.947]; citations – 51; Quartile ranking: Q1. 65. Ariffin H., Muthukumaran T., Stanslas J., Sabariah A.R., Veerasekaran N., Lin H.P., (2005). Secondary B-cell acute lymphoblastic leukaemia following Wilms’ tumor: Clinical and in vitro chemosensitivity studies. Leukaemia and Lymphoma, 46(8): 1233-1237. [IF= 2.605]@; citations – 2; Quartile ranking: Q2; *CAU. 66. Permana D., Abas F., Maulidiani Shaari, K., Stanslas J., Ali, A.M and Lajis N.H. (2005). Atrovirisidone B, a New Prenylated Depsidone with Cytotoxic Property from the Roots of Garcinia atroviridis. Z. Naturforsch. 60c: 523-526. [IF = 0.776]; citations – 14; Quartile ranking: Q4. 67. Missailidis S., Stanslas J., Modi C., Ellis M.J., Robins R.A., Laughton C.A., Stevens M.F. (2002). Antitumor polycyclic acridines.Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design. Oncology Research, 13(3):175-189. [IF = 1.193]; citations – 12; Quartile ranking: Q4. 68. Abdul Wahab K., Stanslas J., Abu Bakar A., Promwichit P., Aziz S, Marzuki S., & Oon K.W. (2001).Cytotoxic and Antioxidant Properties of Wood Tissues of Three Malaysian Timber Species. Journal of Tropical Medicinal Plants, 2(2): 163-168; citations – 0; *CAU 69. Stanslas J., Hagan D.J., Ellis M.J., Turner C., Carmichael J., Ward W., Hammonds T.R., Stevens M.F.G. (2000). Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA-affinic tetra- and penta-cyclic acridines. Journal of Medicinal Chemistry 43: 1563-1572. [IF = 5.504]; citations – 57; Quartile ranking: Q1. 70. Hawariah A. and Stanslas J. (1998). In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Research, 18(6A): 4383-4386. [IF = 1.879];citations – 14; Quartile ranking: Q3. 71. Hawariah A. and Stanslas J. (1998). Antagonistic effects of styrylpyrone derivative (SPD) on 7,12-dimethylbenzanthracene-induced rat mammary tumors. In Vivo 12(4):403-410. [IF = 1.286]; citations – 16; Quartile ranking: Q3. 72. Pihie A.H., Stanslas J. and Din L.B. (1998). Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Research, 18(3A):1739-1743. [IF = 1.879]; citations – 53; Quartile ranking: Q3.
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73. Noah R.M., Zauyah Y., Jais M.R., Stanslas J., Lope Pihie A.H. (1995). Modulation of macrophage function in rats treated with a styrylpyrone derivative. Science International (Lahore), 7(2): 299-30; citations – 0. 74. Zauyah Y., Noah R.M., Jais M.R., Stanslas J., Lope Pihie, A.H. (1995). Effect of a styrylpyrone derivative on rat lymphoid cells. Science International (Lahore), 7(3): 373-375; citations – 0.
#CA – corresponding author
*CAU – corresponding author from UPM
IF - 5-year impact Factor
Scopus
H-Index: 15
Total citations: 796
Google Scholar
H-Index: 17
i10-Index: 29
Citations: 1084
b. Non-cited Journal 1. Zauyah Y., Lope Pihie, A.H., Noah R.M., Stanslas J. (1997). Cytotoxicity of goniothalamin on hormone-dependent breast cancer cells. Malaysian Journal of Biochemistry and Molecular Biology, 2: 29-32. 2. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F and Stanslas J. (2005). Semisynthesis of Andrographolide Analogues and Evaluation of Their Anticancer Properties. Bioscientist, 3(2):18. 3. Jada S.R., Matthews C., Saad M.S., Hamzah A.S, Lajis N.H., Stanslas J. (2010). Andrographolide Derivatives Suppress the Growth of Cancer Cells. Synthesis, 28: 7. 4. Stanslas J. Translational Research and Drug Discovery for Cancer Treatment (2012). Greater Kuala Lumpur. 165 (ISBN 978-3-932831-42-3), KVB Publishing House, Munich, Germany.
Editorial Board Member
11
World Journal of Pharmacology
WebMedCentral Pharmacology
ISRN Pharmacology
Journal Reviewer
Journal of Pharmacology and Experimental Therapeutics (JPET)
European Journal of Pharmacology
British Journal of Pharmacology
Clinical and Experimental Pharmacology and Physiology
Journal of Pharmacy and Pharmacology
Scientific Reports
Investigational New Drug
Anticancer drugs
PLOS One
Pharmaceutical Biology
Yonsei Medical Journal
Iranian Journal of Pharmacology and Therapeutics
Journal of Ethnopharmacology
Journal of Natural Products
Planta Medica
Phytochemistry
Process Biochemistry
Biochimie
Molecular and Cellular Endocrinology
Letters in Drug Design & Discovery
Medicinal Chemistry
Redox report
Journal of Cancer Research and Experimental Oncology
Malaysian Journal of Medicine and Health Sciences
Malaysian Journal of Medicine
Grant Reviewer
University of Kuwait
Ministry of Science, Technology and Innovation, Malaysia (Sciencefund and Technofund – Biopharmacy and Science & Technology)
Ministry of Agriculture, Malaysia
12
Institute of Medical Research, Ministry of Health, Malaysia Proceeding(s) Local 1. Siti Selina AH, Fauziah O, Ghrissi M, Azmi M and Stanslas J. Gene therapy of VP in human breast cancer cell line (MCF-7): A TEM study. (1999). Electron Microscopy Society of Malaysia: Proc 8th Scient Conference, 133-134. 2. Azimahtol H.L.P., Stanslas J. (1994). Compound H: a natural anti-breast cancer agent. Proc.Of COSTAM. 3. Zauyah Y., Azimahtol H.L.P., Stanslas J. (1994). Synergistic antiproliferative effect of goniothalamin and tamoxifen on MCF-7 cells. Proc. Academy of Science Malaysia, KL, Malaysia. 4. Azimahtol H.L.P., Stanslas J., Ramli M.F., Laily D. (1994). Pharmacodynamics of a styrylpyrone derivative. Proc. Malaysian Biochem. Soc. Conf. 5. Asmawati D., Stanslas J., Azimatol H.L.P. (1994). Effect of strylpyrone derivative as a potential antitumor agent on physiological factors of rats. Proc. Malaysian Biochem Soc Conf.. 6. Stanslas J., Azimahtol H.L.P. A preliminary study to evaluate the antitumour activity of goniothalamin in DMBA-induced rat mammary tumor model. (1993). Proc. 2nd IRPA-UKM Workshop: 851-854. 7. Stanslas J., Azimahtol H.L.P. (1992). Goniothalamin: a naturally occurring antiprogestagenic agent devoid of estrogenic and antiestrogenic activities in immature rat uterus. Proc. Malaysian Biochem. Soc. Conf. 17: 113-119. 8. Stanslas J., Azimahtol H.L.P., Laily D. (1991). Effect of goniothalamin on breast cancer cell lines. Proc. 4th. Natl. Biol. Sym. (Malaysia). 10. Azimahtol H.L.P., Stanslas J., Devraj, T., Manimaran S., Laily D. The potential of Goniothalamus extracts as antitumor agents. (1992). Proc. Malaysian Biochem. Soc. Conf. 17: 1-9. 11. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1991). Immunocytochemical evidence for the uptake of Goniothalamus extracts by estrogen receptor positive tissues. 4thNatl. Mol. Sem.And 2nd Scientific Meeting of Malaysian Soc.Of Molecular and Cellular Biology, 47.
International
1. Bostock-Smith C.E., Stanslas J., Gimenez-Arnau E., Missailidis S., Laughton C.A., Searle M.S., Stevens
M.F. (1999).Non-covalent encounters between DNA and a new pentacyclic heteroaromatic salt and the
biological sequelae. Proceedings of the American Association of Cancer Research 40.
13
2. Zauyah Y., Stanslas J., Azimahtol H.L.P. A comparative study of the effect of goniothalamin and
tamoxifen on three breast cancer cell lines. (1993). 10th Ann. Sem. and UNESCO Reg. Workshop on the
Bioassay Guided Isolation of Natural products, 31 (Abs).
3. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). .Antiprogesterone and antiestrogenic effects
of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and
Other Natural Products (ASOMPS VII) MP-17 (Abs).
4. Azimahtol H.L.P., Stanslas J., Laily D. (1991). Anti-implantation effect of goniothalamin from
Goniothalamus tapis. 6thSoutheast Asian Pacific Regional Meeting of Pharmacologists 4218:132.
Seminar Papers Presented (oral)
International
1. Yong, A., Lajis N., Shaari K., Saad S., Stanslas J. (2011). Anticancer potential of standardised
Andrographis paniculata extract in prostate cancer models. International Conference on Natural
Products (ICNP, 2011), 14 – 16 November 2011, Palm Garden Hotel, IOI Resort Putrajaya, Malaysia.
(Oral presentation)
2. Yong A., Shaari K., Lajis N, Saad S., and Stanslas J. (2005). Stability of Bioactive Diterpenoid Lactones in
Andrographis paniculata Nees .Inaugural International Congress on Complementary and Alternative
Medicine (ICCAM), 26-28 February, Singapore (Abs pg 58, Oral presentation).
3. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R and Stevens M.F.G. Novel polycyclic
acridines as topoisomerase II inhibitors. (1997). The 8th Conference on DNA Topoisomerases in Therapy
(Amsterdam, Netherlands), 10 (Abs.) (oral presentation).
4. Schwalbe C.H., Bache C.J., Rathbone D. L., Sagineedu S.R., Jada S.R., Stanslas J., Stevens M.F.G. (2006).
Effect of Blocking Groups on the Confirmation and Intermolecular Interactions of Andrographolide.The
2006 Meeting of the American Crystallographic Association, 22-27 July 2006, Honolulu, Hawaii (Abs
W0329, Oral Presentation).
5. Umar-Tsafe N., Stanslas J., Din L.B., Ali A.M. (2000). Apoptosis-inducing potential of goniothalamin in
human leukaemia cells. The 16th Meeting of the European Association of Cancer Research (EACR),
Halkidiki, Greece (Oral – MS38).
Local 1. Jabir R.S., Ho G.W., Azrif A.A., Stanslas J. (2012). Association of side effects and single nucleotide polymorphism of genes involved in mwtabolism and transport of Docetaxel in Breast Cancer Patients. Annual Scientific Congress of Malaysian Oncological Society 2012, 6th – 9th September, Melaka.
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2. Wong M.S., Sagineedu S.R., Khalivulla S.K., Lajis N.H., Sidik S., Mahmud R., Stanslas J. (2009). New Semisynthetic Compounds in the Treatment of Invasive and Metastatic Cancers. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 36, Oral Presentation). 3. Jabir R.S., Toe A.A., Annuar M.A.A., Stanslas J. (2009). Antiangiogenic Therapy in Cancer: Promises and Realities. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 39, Oral Presentation). 4. Zakaria S.M., Maulidiani., Khamis S., Shaaru K., Lajis N.H., Tang S.C., Lim S.H., Stanslas J. (2009). Comparison of Cytotoxic Properties of Randomly Collected Plants From Different Localities: A Malaysian Case Study. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 45, Oral Presentation). 5. Hassan N.H., Lim S.M., Stanslas J, Lim S.H. (2006). Antitumour Activity of SRJ13, a New Semisynthetic Derivative of Andrographolide in Breast Cancer Cell Lines. Proceedings of the 6th Malaysian Pharmaceutical Society Pharmacy Scientific Conference 2006, Crown Princess Hotel Kuala Lumpur, 8th – 10th September 2006. 6. Wijayahadi, N., Haron, M.R., Stanslas, J and Yusuf, Z. (2004). Immune Cell Changes in Primary Breast Cancer Patients Undergoing Chemotherapy with FEC Regimens.9th National Conference on Medical Sciences, USM, Kubang Kerian. (Abs pg 86, Oral Presentation). 7. Rozida, M.K., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004).Isolation of Bioactive Compounds from Garcinia urophylla.20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 28, Oral Presentation). 8. Muthukumaran T., Stanslas J., Hany Ariffin Lim S.M., Sabariah A.R., Veera Sekaran N., Lin H.P. (2002). Paediatric secondary acute lymphoblastic leukaemia: A case study based on in vitro chemosensitivity assay. The 4th Malaysian National Haematology Scientific Meeting, Penang, Malaysia (Oral presentation).
Other Presentation (Poster/Product/Exhibition/Showcase) International 1. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Vomiting in docetaxel chemotherapy: which to blame, dose or gene? The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement, (FASEB J, 28,1 (655.4)). 2. Stanslas J., Wong C.C., Periasamy N., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H. (2014). In vitro 3D evaluation of penetrability of SRJ09, a semisynthetic anticancer agent. The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement (FASEB J, 28,1 (1048.4)).
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3. Sani D., Ramli N., Kirby B., Sumon S., Basri H., Stanslas J. (2014). Andrographolide downregulates pro-inflammatory cytokines and free radical productions to prevent dopaminergic neuro-degeneration induced by lipopolysaccharide. The Faseb Journal, Experimental Biology, 26th-30th April San Diego Convention Centre. Meeting Abstract Supplement (FASEB J, 28,1 (1143.16)) 4. Jabir R.S., Ho G.F., Azrif M., Stanslas J. (2014). Docetaxel-induced mucositis in breast cancer patients: Association with plasma alpha-1-acid glycoprotein level and SLCO1B3 genotype. American Association of Cancer Research (AACR) annual meeting, 5th-9th April San Diego Convention Centre. (Abstract no. 5563). 5. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S.M., Sumon S.H., Phillips R., Lajis N.H. (2014). SRJ09, a semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon cancer cell lines. American Association of Cancer Research (AACR) annual meeting, 5th-9th April San Diego Convention Centre. (Abstract no. 4454) 6. Chong P.L., Jaafar H.Z.., Stanslas J., Ibrahim M.H. (2013). Total phenolic content and antioxidant activity of Labisia pumila Blume cultivated under nitrogen and potassium fertilization. 5th Global Summit on Medicinal and Aromatic Plants, 8th-12th December, Miri, Sarawak, Malaysia. 7. Stanslas J., Wong C.C., Sagineedu S.R., Sidik S., Summon S.H., Philips R., Lajis N.H. (2013). Mechanism of resistance to a semisynthetic anticancer andrographolide derivative: Possible involvement of Ras-MAPK signaling pathway. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes Convention Center, Boston, MA, United States. Meeting Abstract Supplement (Abs C147, pg 378) 8. Jabir S., Ho G.F., Ahmad Annuar M.A., Stanslas J. (2013). Single nucleotide polymorphisms of ABCB1, SLCO1B3, and CYP3A5: Potential biomarkers of docetaxel adverse effects in Malaysian breast cancer patients. Molecular Targets and Cancer Therapeutics, 19th – 23rd October, Hynes Convention Center, Boston, MA, United States. Meeting Abstract Supplement (Abs A210, pg 184) 9. Wong H.C., Sagineedu S.R., Loke S.C., Lajis N.H., Stanslas J. (2012). SRJ23, a potent inducer of cell cycle arrest and apoptosis in prostate cancer cells. Experimental Biology 2012, 21st – 25th April, San Diego, California, United States. Poster presentation, Meeting Abstract Supplement, 851.9 (FASEB J, 26 (851.9)). 10. Wong H.C., Sagineedu S.R., Lajis N.H. and Stanslas J. (2010).SRJ23, A new investigational anti-prostate cancer agent. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States. Poster presentation, Meeting Abstract Supplement, 964.6 (FASEB J, 24 (964.6)). 11. Stanslas J., Lim S.H., Wong C.C., Sagineedu S.R. and Lajis N.H. (2010). Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.Poster presentation, Meeting Abstract Supplement, 773.2 (FASEB J, 24 (773.2)). 12. Jabir R.S., Naidu R., Azrif M and Stanslas J. (2010). Efficacy versus toxicity of docetaxel in Asian and Caucasian cancer patients from the pharmacogenomics perspectives: a review of the literature. Experimental Biology 2010, 24th-28th April, Anaheim, California, United States.Poster presentation, Meeting Abstract Supplement, 964.15 (FASEB J, 24 (964.1)).
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13. Wong C.C., Sagineedu S.R., Lajis N.H., Stanslas J. (2010). Two Semisynthetic Anticancer Lead Compounds: Assessment of In Vitro Activities against Breast and Colon Cancers. Recent Development in Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological University Singapore (Abs pg 78, Poster presentation). 14. Wong H.C., Sagineedu S.R., Lajis N.H, Stanslas J. (2010). A New Semisynthetic Compound Derived from Andrographolide Displays Impressive In Vitro Activity Against Prostate Cancer Cells. Recent Development in Chinese Herbal Medicine (RDCHM), 25th – 26th January, Nanyang Technological University Singapore (Abs pg 79, Poster presentation). 15. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad, M.S. (2008). New clerodane diterpenes from Casearia capitellata as potential antitumour agents.20th EORTC - NCI - AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 58)European Journal of Cancer (Suppl) 132, p 43. 16. Stanslas J., Lim S.H., Jada S.R., Sagineedu S.R., Lajis N.H., Stevens M.F. (2008). SRJ09, a lead compound in anticancer drug design: in vitro, in vivo and mechanistic studies. 20th EORTC - NCI - AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Poster presentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 43). 17. Stanslas J., Bagalkotkar G., Tang S.C., Hamzah A.S., Shaari K., Lajis N.H., Saad M.S. (2008). New antitumour agents from Phyllanthus pulcher, a tropical medicinal plant. 20th EORTC - NCI - AACR Symposium on“Molecular Targets and Cancer Therapeutics”, Geneva, Switzerland, 21 - 24 October (Posterpresentation, European Journal of Cancer Supplements, Volume 6, Issue 12, October 2008, Pages 58-59). 18. Stanslas J (2006). Discovery and Development of Natural and Synthetic Anticancer Agents. International Conference: Exploring New Frontiers in Medicine and Health. 1-2 August 2006, PWTC, Kuala Lumpur (Abs S6.1 pg 50, Invited Speaker). 19. Lim S.M., Stanslas J and Ariffin H. (2006). A case study of precursor B-cell ALL with BCR-ABL fusion gene showed chemoresistance in vitro. The 10th International Symposium On Oncology Pharmacy Practice, 3-6 April 2006, Kuala Lumpur (Abs pg 76, Poster Presentation). 20. Jada S.R., Sageneedu S.R., Hamzah A.S., Stanslas J., Stevens MFG, Chowbay B. (2005). Structure Activity Relationship and Antitumour Activities of Andrographolide and its Novel Derivatives. Annals Academy of Medicine NHG & SingHealth (Poster Abstracts). BAS 176, pg S70. 21. Jada S.R., Mathews C., Stevens M.F and Stanslas J. (2005). Mechanisms of Antitumour Activities of Andrographolide Derivatives. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 15, Poster Presentation). 22. Wijayahadi N., Yusuf Z., Stanslas J., and Haron M.R. (2005). Comparison of Side Effects of Chemotherapy Regimens with Epirubicin and Doxorubicin on Profiles of Immune Cells of Breast Cancer
17
Patients. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 17, Poster Presentation). 23. Wijayahadi N., Yusuf Z., Haron M.R and Stanslas J. (2005).CD28 Expression on Lymphocytes of Breast Cancer Patients Undergoing Chemotherapy. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 18, Poster Presentation). 24. Jada S.R., McCarroll A., Mathews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F., and Stanslas J. (2005). Semisynthesis of Antitumour Andrographolide Derivatives. United Kingdom National Cancer Research Institute (NCRI) Cancer Conference, 2-5 October, Birmingham (Abs pg 60, Poster Presentation). 25. Ali Abdalla J., Yong A., Abdul Kadir M., Stanslas J., and Saad M. S. (2005).Molecular and Phytochemical Variability of Andrographis paniculata Germplasms in Malaysia. Inaugural International Congress on Complementary and Alternative Medicine (ICCAM), 26-28 February, Singapore (Abs pg 116, poster presentation). 26. Jada S. R., Stanslas J., Lajis N.H., Saad S., Hamzah A.S., McCorroll A., Mathews C and Stevens M.F.G. (2003). APAG-1 derivatives as antitumour agents. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 27. Stanslas J., Yahaya R.N.R and Jada S.R. (2003).Inhibition of proteasome function as a mechanism of antitumour activities of naturally occurring lactone ring-based compounds and their synthetic derivatives. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 28. Stanslas J., Manikam S.D and Holme A. (2003). Induction of differentiation and apoptosis by APAG-1 in acute promyelocytic leukaemia cells. British Cancer Meeting, 2-5 July, Bournemouth, UK (poster presentation). 29. Stanslas J., Liew P.S., Iftikhar N., Lee C.P., Saad S., Lajis N., Robins R.A., Loadman P., Bibby M.C. (2001). Potential of AG in the treatment of breast cancer. 11th European Cancer Conference (ECCO), Lisbon, Portugal (poster presentation). 30. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens MFG. Topoisomerase II inhibiting antitumour polycyclic acridines. (2000). The 16th Meeting of the European Association of Cancer Research (EACR), Halkidiki, Greece (poster - FP51). 31. Zauyah Y., Stanslas J., Noah R.M., Jais M.R., Lope Pihie A.H. (2000). Stimulation of the immune system as a mechanism of tumour prevention by goniothalamin. The 16th Meeting of the European Association of Cancer Research (EACR), Halkidiki, Greece (Poster – FP50). 32. Hagan D.J., Stanslas J., Ellis M.E., Missailidis S., Arnau E.G., Double J.A., Stevens M.F.G. (1998). New DNA interactive aza-polycyclic compounds: Physical and biological properties. Annals of Oncology 9 No.S2, p.135. 33. Stanslas J., Marsh K.L., Austin C.A., Robins R.A., Price M.R., Double J.A., Stevens M.F.G. (1998). Antitumour properties of novel aza-polycyclic compounds. British Journal of Cancer, 78, No.S1, p.P32.
18
34. Arnau E.G., Missailidis S., Hagan D.J., Stanslas J., Stevens M.F.G. (1997).Studies on the interactions between DNA and novel polycyclic acridine derivatives. British Journal of Cancer, 75, P7, 20. 35. Zauyah Y., Stanslas J., Azimahtol H.L.P. (1993) A comparative study of the effect of goniothalamin and tamoxifen on three breast cancer cell lines. 10th Ann. Sem. and UNESCO Reg. Workshop on the Bioassay Guided Isolation of Natural products, 31 (Abs). 36. Azimahtol H.L.P., Stanslas J., Hamid A., Laily D. (1992). Antiprogesterone and antiestrogenic effects of goniothalamin on estrogen target tissues. 7thAsian Symposium on Medicinal Plants, Species and Other Natural Products (ASOMPS VII) MP-17 (Abs).
Local
1. Tan S.F., Basri M., Stanslas J., Basri H. (2013). Development of nanoemulsion loaded with valproic acid with response surface methodology. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 4). 2. Tan S.M., Stanslas J., Karjiban R.A., Kirby B., Basri M., Basri H. (2013). The preparation and characterization of carbamazepine-encapsulated nanoemulsion targeting the brain via parental administration. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 24) 3. Daood G.S., Basri H., Stanslas J., Basri M. (2013). The preparation and characterization of carbamazepine-encapsulated nanoemulsion targeting the brain via parental administration. 26th Regional Symposium Malaysia Analytical Sciences, 4th – 5th December, Kuching (Abs pg 24) 4. Suppaiah V., Zareen S., Shaari K., Lajis N.H., Stanslas J. (2009). Inhibition of Leukotriene Production by Compounds and Extracts of Melicope ptelefolia: A Potential Role in the Treatment of Asthma. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 75, Poster Presentation). 5. Lim C.W., Sagineedu S.R., Khalivulla S.I., Sidik S.M., Abdul Latif A.H.D., Lajis N.H., Wong W.S.F., Stanslas J. (2009). In Vitro Cysteinyl Leukotriene Synthesis Inhibition by Natural and New Semi-synthetic Diterpenoids in Murine Macrophages: Potential for Development of New Antiasthma Agent. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 76, Posterl Presentation). 6. Ramli N., Stanslas J., Jamal J.A. (2009). Estrogenic Effect of Labisia Pumila Var Alata Extracts In Vitro. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 80, Poster Presentation).
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7. Wong H.C., Sagineedu S.R., Khalivulla S.I., Lajis N.H., Stanslas J. (2009). SRJ23, A Promising New Anti-prostate Cancer Agent. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 97, Poster Presentation). 8. Wong C.C., Sagineedu S.R., Khalivulla S.I., Stanslas J. (2009). SRJ09 and SRS88, Two Lead Anticancer Agents: Growth Inhibition, Cell Cycle Arrest and Cell Death Induction of Breast and Colon Cancer Cells. 23rd MSPP Scientific Meeting (12th – 13th May), Grand Seasons Hotel, Kuala Lumpur (Abs pg 99, Poster Presentation). 9. Lim S.M., Stanslas J and Ariffin H. (2005). Development of a predictive assay for treatment of childhood leukaemia. Malaysian Pharmaceutical Society Pharmacy Scientific Conference, Sunway Pyramid (Abs pg 54, Poster Presentation). 10. Jabit, M.L., Lajis, N.H.L., Khozirah, S and Stanslas, J. (2004). Bioassay-directed Isolation of Compounds from Garcinia penangiana Leaf Extract. 20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 59, Poster Presentation). 11. Faridah, A, Lajis, N.H.L., Lim S. H., Syahida, A., Stanslas, J., Israf, D.A., Khozirah, S., Umi Kalsom, Y and Othman, A.G. (2004). Semisynthesis and Biological Evaluation of Curcumin Related Diarylheptanoids. 20th Annual Seminar of the Malaysian Natural Products Society (Abs pg 66, Poster Presentation). 12. Ali Abdalla J., Saad S., Stanslas J., Abdul Kadir M., Mohamed R, Yong A. (2003). Genetic variations and antitumour activity of Andrographis paniculata. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 93) (poster presentation). 13. Yong A., Chong G.H., Stanslas J., Ibrahim M.N., Lajis N., Shaari K., and Saad S. (2003). Stability Study of Bioactive Diterpenoid Lactones in Andrographis paniculata Nees. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation). 14. Saif-Ali R., Jada S.R., Stanslas J., Saad S., Lajis N., Hamzah S.H. (2003). Antitumour Activities of Synthetic Derivatives of APAG-1. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 92) (poster presentation). 15. Bagalkotkar G., Stanslas J., Lajis N., Shaari K., Saad S., Hamzah AS (2003). Cytotoxic Potential of Compounds Isolated from A Phyllanthus Sp. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 89) (poster presentation). 16. Suppaiah V., Mohd Asihin M.A., Sekawi Z., Stanslas J. (2003). In Vitro Antiviral Activity of Two Local Herbs Against Dengue Virus Type-2. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 91) (poster presentation). 17. Jabit M.L., Lajis N.H., Stanslas J. (2003). Cytotoxic activities of Malaysian Garcinia species extracts. 19th Annual Seminar and Workshop of the Malaysian Natural Product Society, Kuala Lumpur, Abs (pg 73) (poster presentation).
20
Research activities
Research Grants
a) Project leader
Year Project title Source Status
2015-2016 Prophylaxis of asthma and COPD with a standardised herbal extract
NKEA Research Grant Scheme (NRGS), Ministry of Agriculture
On-going
2014-2016 Single Nucleotide Polymorphisms, Psycho-social and Nutritional Risk Factors for Major Depressive Disorder and Response to Drug Therapy
Putra Grant, Universiti Putra Malaysia
On-going
2013-2015 Blocking Signalling in Cancer Stem Cells to Eradicate Relapse in Cancer Chemotherapy
Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education of Malaysia
On-going
2012-2015 SRJ23 and Its Derivatives as New Anticancer Agents Targeting RAS-MAP
Kinase and NF-B Pathways: in vitro, in vivo, in silico and protein crystallography approaches
Research University Grant Scheme (RUGS), UPM
On-going
2012-2014 Potential of a standardised aqueous extract of a local herb as a cognition enhancer via maintenance and increased integrity of neuroplasticity: roles of anti-neuroinflammation and anti-oxidative properties
NKEA Research Grant Scheme (NRGS), Ministry of Agriculture
completed
2010-2012 Pharmacogenetics of Docetaxel in Malaysian Metastatic Breast Cancer Patients
Fundamental Research Grant Scheme (FRGS), Ministry of
Completed
21
Higher Education of Malaysia
2009-2011
Molecular Mechanisms of Cell Cycle Arrest and Apoptosis Induced by Semisynthetic Diterpenoids in Cancer Cell Line
Research University Grant Scheme (RUGS), UPM
Completed
2007-2009
Formulation, Gastrointestinal Transit and Absorption from Nano-particular Dispersion of Amphotericin B
SCIENCEFUND
Completed
2008-2010
Chemical Characterization, Standardization and Biological Evaluation of Melicope ptefolia Towards Their Development into Antiinflammatory Nutraceutical Products
Biopharmacy (National Pharmaceutical Institute) (MOSTI):
Completed
2007-2009
Evaluation of New Andrographolide Derivatives for Inhibitory Activities Against Tumour Vasculature and Metastasis
SCIENCEFUND CYCLE 1/2006:
Completed
2001-2002
Mammogram Imaging in the Diagnosis of Breast Cancer (University Malaya Medical Centre - UPM)
Faculty’s Students’ Project Fund
Completed
2001-2003
In vitro Assessment of the Efficacy of Standard Chemotherapeutic Drugs used in the Treatment of Childhood Leukaemia at the University Malaya Medical Centre (UMMC-UPM)
Faculty’s Students’ Project Fund
Completed
2003-2006 Synthesis of andrographolide derivatives and evaluation of their antitumour potential
UPM-IRPA EA RM8
Completed
2002-2005 Stability of bioactive diterpenoid lactones in A. paniculata’.
IRPA-PR_BTK IMR_RM8
Completed
2000-2003 Evaluation of the antitumour potential of compounds of Andrographis paniculata (andrographolide, neoandrographolide, andrographiside)
UPM-IRPA EA-RM7
Completed
22
1999-2000 New lecturer research scheme (two)
UPM
Completed
b) Co-researcher
Year Project title Project
leader
Source Status
2015-2016 Investigating the
role of anti-
inflammatory
property of natural
compounds and
their derivatives in
the treatment of
psoriasis: in vitro
studies
Dr Audrey
Yong Chee
Hui
MAHSA
University
On-going
2014-2015 Medicinal
Properties,
Nutritional Values
and Safety Profiles
of Edible Bird’s
Nest
Prof Madya
Christopher
Lim
CoE Swiftlet
Grant
On-going
2011 – 2013 Standardisation of
aqueous extract of
a local medicinal
herb based on the
anti-gout and anti-
inflammatory
activities
Prof Madya
Dr Jamia
Azdina Jamal
NKEA
Research
Grant Scheme
(NRGS),
Ministry of
Agriculture
Completed
2011 – 2013 Biosynthesis of
acylated quercetin
analogues and
evaluation of their
anticancer
Dr Choo Wee
Sim
Sciencefund Completed
23
activities
2011 – 2013 NMR-based
metabolomics
fingerprinting and
profiling of Labisia
Pumila varities and
biofluids (animal
metabolic study) in
the detection of
biomarker in
diabetic induced
rats
Prof Madya
Hawa Jaafar
NKEA
Research
Grant Scheme
(NRGS),
Ministry of
Agriculture
Completed
2011 - 2012 HPLC method
development and
validation of
determination of a
pharmaceutical
agent in mice
plasma
Dr. Audrey
Yong
SEGi
University
College
Research Fund
Completed
2010 - 2013 Development of Andrographolide and its Derivatives for the Treatment of Allergic Asthma and Asthma Exacerbation
Assoc Prof Dr
Fred Wong
Biomedical Research Council (BMRC), Singapore
Completed
2007 – 2009 Production of Coenzyme Q10 with Improved Bioavailability for Food Supplement from Tobacco Leaves
Assoc Prof Lai
Oi Meng
Techofund (MOSTI)
Completed
2007 – 2009
Anti-inflammatory and and Oestrogenic Effects of Compounds isolated from
Assoc Prof Dr Jamia Azlina Jamal
Sciencefund Cycle 1: 2006
Completed
24
Labisia spp (MYRSINACEAE)
2005 –2007
Investigation into Gene Expression and Metabonomic Profiling of Endometrial Cancer using Transgenic Animal Model
Dr Mohd Nazil Salleh
Scientific Advancement Grant Allocation (SAGA) Fund
Complete
2000-2005 Isolation and characterisation of antitumour agents from Phyllanthus pulcher
Assoc Prof Dr Said Saad
UPM-IRPA EA RM8
Complete
Patent Filed
Patent title: Cysteinyl Leukotriene Inhibitor Comprising 2,4,6-trihydroxygeranylacetophenone (tHGA) as an Active Ingredient (PI201000968)
Patent holder: Khozirah Shaari, Johnson Stanslas, Velan Suppaiah, Seema Zareen, Faridah Abas, Daud Ahmad Ishraf, Nordin Haji Lajis
Consultation activities
(a) Lead project consultant
No. Name of Consultant(s)
Name of Project/Program
Year Status (Completed/On-
going)
1 Autoimmune Sdn Bhd
To evaluate the anticancer potential of botanical extracts and antihepatotoxic effect of HepatTM
June 2004 – May 2005
Completed
2 Country Heights Health
Provide advice on the purchase and
July 2005 – June 2006
Completed
25
Sanctuary (CHHS), Palace of Golden Horses, Seri Kembangan, Serdang
running of diagnostics and health screening equipment at CHHS
3 Arah Mashur Sdn Bhd
Assessment of in vitro anticancer potential of AM botanical extracts
January 2006 – March 2006
Completed
(b) Co-project consultant
No Company Project title Duration
1 Black Gold Sdn Bhd Production of Coenzyme Q10 With Improved Bioavailabity for Food Supplement from Tobacco Leaves
September 2007 – August 2009
Extension and other public services
No. Name of Activity/Project/
Program
Organiser Place Date
1 Anugerah Tidak Ternilai – Anugerah Herba
RTM TV1 Malaysia November 2004
Awards
International
1. International Invention, Innovation and Technology Exhibition (ITEX) - 15-17 Mei 2009 (KLCC) ‘SRJ09, A Lead Compound in Anticancer Drug Discovery’ - Bronze medal
2. 2nd place for Best Poster presentation for Division of Drug Discovery, Development and Regulatory Affairs (American Society for Pharmacology and Experimental Therapeutics), Experimental Biology 2012, 21st – 25th April, San Diego, California, United States
26
National
1. Best Poster Presentation ‘In vitro cysteinyl leukotriene synthesis inhibition in murine macrophage by natural and new semi-synthetic diterpenoids: potential for development new anti asthma agent’ - 23rd Malaysian Society of Pharmacology and Physiology Scientific Meeting, Kuala Lumpur, 12th – 13th May 2009.
2. Best Poster for Pharmaceutical Chemistry/Traditional and Complementary Medicine/Basis of Therapeutics/Pharmacology - 6th Malaysian Pharmaceutical Society Pharmacy Scientific Conference 2006, Crown Princess Hotel Kuala Lumpur, 8th – 10th September 2006.
3. 2nd place for Best Presenter at the Annual Scientific Congress of Malaysian Oncological Society (ASCOMOS) 2012, Melaka, Malaysia
University
Universiti Putra Malaysia research awards 2009 – 2 gold medals
1. Inhibition of Leukotriene Production by Compounds and Extracts of Melicope Ptelefolia: Potential Role in the Treatment of Asthma
2. SRJ23, A Promising New Anti-Prostate Cancer Agent
Universiti Putra Malaysia research awards 2007 – 2 gold, 3 silver and 1 bronze medals
Gold
1. SRJ09, A Lead Compound In Anticancer Drug Design
2. Inhibition of Tumour Growth Through Suppression of Angiogenesis By a natural compound.
Silver
1. Therapeutic Potential of Standardised AndroPan for the Treatment of Prostate Cancer.
2. Design And Synthesis Of Andrographolides As Potential Anticancer Agents: Discovery Of Cytotoxic And
Antiangiogenic Agents.
3. Isolation of New Clerodane Diterpenes From Casearia capitellata As Potential Antitumour Agents.
Bronze
1. Structure Elucidation and Antitumoural Properties Of New Terpenoid Derivatives From Phyllanthus
pulcher
Universiti Putra Malaysia research awards 2005 - 3 bronze medals
27
1. Pharmacokinetic and Antitumour Studies of Diterpenoid Lactones of Andrographis paniculata Nees – Institute of Bioscience.
2. HTLV-1 Tax Gene in Adult Leukaemia and Lymphoma Cells and In Vitro Chemosensitivity Profiles – Faculty of Medicine and Health Sciences
3. Anti-Dengue Compounds from Thottea sp - Faculty of Medicine and Health Sciences
Universiti Putra Malaysia research awards 2004
Gold Medal
Title: Semisynthesis of Antitumour Andrographolide Derivatives
2. Silver Medal
Title: Mechanisms of antitumour activities of andrographolide derivatives
3. Bronze Medal
Title: Suitable Drying and Storage Conditions to Maintain the Stability of Andrographolide in Andrograhis paniculata Nees
Excellence Service Award, Universiti Putra Malaysia: 2004 dan 2010
Administrative duties and other relevant appointment
No. Position Department/Faculty/Other Institution Year
1 Head of
Pharmacotherapeutics Unit
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2008 – present
2 Course coordinator (General
and Biochemical
Pharmacology)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2010 –present
3 Course coordinator
(Molecular Pharmacology)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2004 – present
4 Course coordinator
(Molecular Medicine)
Department of Medicine, Faculty of
Medicine and Health Sciences, UPM
2004 – 2006
Academic duties/committee members
28
No. Title Level (International/National/University/Faculty/Department)
Year
1 Member of the Faculty’s Preclinical Curriculum Committee
Faculty of Medicine and Health Sciences, UPM 2005
2 Member of the Faculty’s Continual Medical Education (CME) Committee
Faculty of Medicine and Health Sciences, UPM 2003 – 2004
3 Advisor to The Putra Medical Club
Faculty of Medicine and Health Sciences, UPM 2003 – 2004
4 Member of the Faculty’s Support Staff Committee
Faculty of Medicine and Health Sciences, UPM 2002 – 2003
5 Member of the Medical Research Ethical Committee
Faculty of Medicine and Health Sciences, UPM 2008 – present
6 Member of the Laboratory Committee
Faculty of Medicine and Health Sciences, UPM 2008 – present
7 Member of the Animal Care and Use Committee
Faculty of Medicine and Health Sciences, UPM 2009 - 2012
8 Research Associate at the Natural Products Laboratory
Institute of Bioscience, UPM 2001 – present
9 Grant reviewer (RUGS, FRGS, ERGS, PRGS)
Universiti Putra Malaysia 2011 – 2014
10 Technical reviewer
Universiti Malaya 2012
11 Project reviewer
University of Kuwait 2011
29
12 Committee member for “Etika Universiti untuk Penyelidikan Melibatkan Manusia (JKEUPM)”
Universiti Putra Malaysia 2012
Involvement in professional association/organization/body
No. Name of Association/Organization/Body
Role (President/Secretary/Committee Member/Ordinary Member
1 National Seminar on ‘Translational Research in Oncology’
Chairperson
2 National Seminar on ‘Paediatric Neurotransmitter Diseases’
Chairperson
3 5th Malaysian Conference on Healthy Ageing
Scientific Chairman
4 2nd Annual Neuroscience Seminar Committee Member
5 International Conference on Natural Products 2011
Committee Member
6 1st World Congress on Healthy Ageing 2012
Committee Member
7 Nobel Laurate Committee of Malaysia Committee Member