CURRICULUM VITAE Soichiro Ishihara, M.D., Ph. D. · CURRICULUM VITAE Soichiro Ishihara, M.D., Ph....

CURRICULUM VITAE

Soichiro Ishihara, M.D., Ph. D.

PERSONAL INFORMATION

Date of Birth: September 9, 1967

Place of Birth: Hyogo

Citizenship: Japan

Professional address and telephone:

Department of Surgical Oncology

The University of Tokyo Graduate School of Medicine

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Tel: 81-3-5800-8744

Fax: 81-3-5800-8819

E-mail address: [email protected]

EDUCATION/POST GRADUATE TRAINING

College/University:

1986-1992 MD, University of Tokyo School of Medicine

1997-2001 PhD in Surgery, University of Tokyo School of Medicine

Residency:

1992-1994 Resident in Surgery, University of Tokyo Hospital

Fellowship:

1994-1997 Fellow in Surgery, University of Tokyo Hospital

MEDICAL LICENSURE

Full Medical License (Japan) #347870

BOARD CERTIFICATION

Japan Surgical Society

The Japanese Society of Gastroenterological Surgery

The Japan Society of Coloproctology

Japan Gastroenterological Endoscopy Society

Japan Society of Endoscopic Surgery

PRESENT POSITION OR ACADEMIC RANK

Professor, Department of Surgical Oncology, The University of Tokyo Graduate School

of Medicine

TEACHING ACTIVITIES-HOSPITAL OR OFFICE-BASED

Medical School:

2003-2008 Assistant Professor, Department of Surgical Oncology, University of Tokyo

2008-2013 Lecturer, Department of Surgery, Teikyo University

2012-2013t Visiting Lecturer, Department of Surgical Oncology, University of Tokyo

2013-2017 Lecturer, Department of Surgical Oncology, The University of Tokyo

2017-2018 Professor, Digestive Surgery, International University of Health and Welfare

2018-present Professor, Department of Surgical Oncology, The University of Tokyo

Graduate School of Medicine

PROFESSIONAL AND SOCIETY MEMBERSHIPS

Membership:

Japan Surgical Society

The Japanese Society of Gastroenterological Surgery

The Japan Society of Coloproctology

The Japanese Society of Gastroenterology

Japan Gastroenterological Endoscopy Society

Japan Society for Endoscopic Surgery

Japan Robotic Surgery Society

Japan Society of Clinical Oncology

International Association of Surgeons, Gastroenterologists and Oncologists

BIBLIOGRAPHY

1. Ishihara S, Nieda M, Kitayama J, Osada T, Yabe T, Ishikawa Y, Nagawa H,

Muto T, Juji T: CD8(+)NKR-P1A (+)T cells preferentially accumulate in

human liver. Eur J Immunol 29(8):2406-2413, 1999

2. Tomozawa S, Nagawa H, Tsuno N, Hatano K, Osada T, Kitayama J, Sunami

E, Nita ME, Ishihara S, Yano H, Tsuruo T, Shibata Y, Muto T: Inhibition of

haematogenous metastasis of colon cancer in mice by a selective COX-2

inhibitor, JTE-522. Br J Cancer 81(8):1274-1279, 1999

3. Ishihara S, Nieda M, Kitayama J, Osada T, Yabe T, Kikuchi A, Koezuka Y,

Porcelli SA, Tadokoro K, Nagawa H, Juji T: Alpha-glycosylceramides

enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from

cancer patients by activating CD3-CD56+ NK cells in vitro. J Immunol

165(3):1659-1664, 2000

4. Ishihara S, Nieda M, Yabe T, Nakayama H, Osada T, Kitayama J, Nagawa H,

Juji T: NKR-P1A+ T cells in human liver: their distinct phenotype and

function. Modern Aspect of Immunobiology 1(2):48-51, 2000

5. Ishihara S, Watanabe T, Umetani N, Yamagata S, Masaki T, Nagawa H, Muto

T: Small advanced colorectal cancers: clinicopathological characteristics and

pathogenetic origin. Jpn J Clin Oncol 30(11):504-509, 2000

6. Ishihara S, Yasuhara H, Ogawa S, Muto T: Successful surgical treatment for

spontaneous retroperitoneal hematoma in polycythemia vera: report of a case.

Surg Today 30(2):199-201, 2000

7. Kikuchi A, Nieda M, Schmidt C, Koezuka Y, Ishihara S, Ishikawa Y,

Tadokoro K, Durrant S, Boyd A, Juji T, Nicol A: In vitro anti-tumour activity

of alpha-galactosylceramide-stimulated human invariant Valpha24+NKT

cells against melanoma. Br J Cancer 85(5):741-746, 2001

8. Nieda M, Kikuchi A, nicol A, Koezuka Y, Ando Y, Ishihara S, Lapteva N,

Yabe T, Tokunaga K, Tadokoro K, Juji T: Dendritic cells rapidly undergo

apoptosis in vitro following culture with activated CD4+ Valpha24 natural

killer T cells expressing CD40L. Immunology 102(2):137-145, 2001

9. Osada T, Nagawa H, Kitayama J, Tsuno NH, Ishihara S, Takamizawa M,

Shibata Y: Peripheral blood dendritic cells, but not monocyte-derived

dendritic cells, can augment human NK cell function. Cell Immunol

213(1):14-23, 2001

10. Takahashi T, Chiba S, Nieda M, Azuma T, Ishihara S, Shibata Y, Juji T, Hirai

H: Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated

by alpha-galactosylceramide-pulsed monocyte-derived dendritic cells. J

Immunol 168(7):3140-3144, 2002

11. Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Saito S,

Ishihara S, Kazama S, Tsuno N, Kitayama J, Suzuki N, Tsurita G, Muto T,

Nagawa H: Prediction of tumor radiosensitivity in rectal carcinoma based on

p53 and Ku70 expression. J Exp Clin Cancer Res 22(2):223-228, 2003

12. Koketsu S, Watanabe T, Kazama S, Ishihara S, Komuro Y, Nagawa H: What

types of colorectal cancer overexpress the MAGE protein?

Hepatogastroenterology 51(60):1648-1652, 2004

13. Watanabe T, Kanazawa T, Kazama Y, Tanaka J, Tanaka T, Ishihara S,

Nagawa H: TP53 mutation and microsatellite instability status for the

prediction of survival in adjuvant-treated colon cancer patients. J Clin Oncol

23(35):9031-9032; author reply 9032-9033, 2005


Nagawa H: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer.

Clin Cancer Res 12(5):1654; author reply 1654-1655, 2006


Nagawa H, Benatti P, Ponz de Leon M, Gafa R, Lanza G, Barana D, Oliani C:

Adjuvant chemotherapy in colorectal cancer patients with microsatellite

instability. Clin Cancer Res 12(12):3866-3867; author reply 3867, 2006

16. Ishihara S, Kitayama J, Nagawa H: Clinical challenges and images in GI.

Amoebic appendicitis. Gastroenterology 133(5):1412, 1747, 2007

17. Ishihara S, Watanabe T, Nagawa H: Intraoperative colonoscopy for stapled

anastomosis in colorectal surgery. Surg Today 38(11):1063-1065, 2008

18. Suzuki H, Tsurita G, Ishihara S, Akahane M, Kitayama J, Nagawa H:

Resovist-enhanced MRI for preoperative assessment of colorectal hepatic

metastases: a case of multiple bile duct hamartomas associated with colon

cancer. Case Rep Gastroenterol 2(3):509-516, 2008

19. Ishihara S, editor. Clinical Benefit of Tegafur-Uracil and Leucovorin in

Preoperative Chemoradiotherapy for Rectal Cancer. The Forth Annual

Academic Surgical Congress; 2009; Florida.

20. Watanabe T, Kobunai T, Tanaka T, Ishihara S, Matsuda K, Nagawa H: Gene

expression signature and the prediction of lymph node metastasis in colorectal

cancer by DNA microarray. Dis Colon Rectum 52(12):1941-1948, 2009

21. Hayama T, Matsuda K, Shibuya H, Akahane T, Horiuchi A, Shimada R,

Aoyagi Y, Nakamura K, Yamada H, Ishihara S, Nozawa K, Watanabe T: A

case of appendiceal Crohn's disease in which a laparoscopic appendectomy

was performed. Int Surg 95(4):338-342, 2010

22. Ishihara S, Watanabe T, Kiyomatsu T, Yasuda K, Nagawa H: Prognostic

significance of response to preoperative radiotherapy, lymph node metastasis,

and CEA level in patients undergoing total mesorectal excision of rectal

cancer. Int J Colorectal Dis 25(12):1417-1425, 2010

23. Shibuya H, Ishihara S, Akahane T, Shimada R, Horiuchi A, Aoyagi Y,

Nakamura K, Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T: A

case of paracecal hernia. Int Surg 95(3):277-280, 2010

24. Watanabe T, Kobunai T, Yamamoto Y, Kanazawa T, Konishi T, Tanaka T,

Matsuda K, Ishihara S, Nozawa K, Eshima K, Muto T, Nagawa H: Prediction

of liver metastasis after colorectal cancer using reverse

transcription-polymerase chain reaction analysis of 10 genes. Eur J Cancer

46(11):2119-2126, 2010

25. Watanabe T, Kobunai T, Yamamoto Y, Konishi T, Yano H, Iinuma H,

Hayama T, Nozawa K, Ishihara S, Matsuda K: Prognostic significance of 18q

loss of heterzygosity in microsatellite-stable colorectal cancer. J Clin Oncol

28(7):e119; author reply e120, 2010

26. Yamada H, Matsuda K, Akahane T, Shimada R, Horiuchi A, Shibuya H,

Aoyagi Y, Nakamura K, Hayama T, Iinuma H, Nozawa K, Ishihara S,

Watanabe T: A case of fulminant amebic colitis with multiple large intestinal

perforations. Int Surg 95(4):356-359, 2010

27. Aoyagi Y, Matsuda K, Shimada R, Horiuchi A, Shibuya H, Nakamura K,

Iinuma H, Hayama T, Yamada H, Nozawa K, Ishihara S, Watanabe T:

Perforation of the small bowel due to metastasis from tongue cancer. Int Surg

96(1):90-93, 2011

28. Hayama T, Ishihara S, Yamazaki N, Akahane T, Shimada R, Horiuchi A,

Shibuya H, Yamada H, Nozawa K, Matsuda K, Watanabe T: Severance of a

ventriculoperitoneal shunt catheter implanted between the cerebral ventricle

and peritoneal cavity, resulting in protrusion from the anus. Int Surg

96(2):148-152, 2011

29. Horiuchi A, Matsuda K, Akahane T, Shimada R, Shibuya H, Hayama T,

Yamada H, Ishihara S, Nozawa K, Watanabe T: A case of marked response to

preoperative chemoradiotherapy for rectal cancer with para-aortic lymph node

metastasis. Int Surg 96(2):139-143, 2011

30. Horiuchi A, Nozawa K, Akahane T, Shimada R, Shibuya H, Aoyagi Y,

Nakamura K, Hayama T, Yamada H, Ishihara S, Matsuda K, Watanabe T:

Skin metastasis from sigmoid colon cancer. Int Surg 96(2):135-138, 2011

31. Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Nozawa

K, Ishihara S, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M:

Reply to B. Faltas et al. J Clin Oncol 29(21):2947-2948, 2011

32. Iinuma H, Watanabe T, Mimori K, Tamura J, Adachi M, Hayashi N, Nozawa

K, Ishihara S, Matsuda K, Baba H, Fukushima R, Okinaga K, Sasako M, Mori

M: Reply to F. Crea et al. J Clin Oncol 29(25):3488-3490, 2011

33. Ishihara S, Fukushima N, Akahane T, Horiuchi A, Shimada R, Shibuya H,

Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T: Neutrophil ratio

predicts prognosis of rectal cancer after chemoradiotherapy.

Hepatogastroenterology 2011

34. Ishihara S, Fukushima Y, Akahane T, Horiuchi A, Shimada R, Hayama T,

Yamada H, Nozawa K, Matsuda K, Watanabe T, editors. Changes in

pathological findings and prognostic factors of rectal cancers treated with

preoperative chemoradiotherapy. 21st World Congress of the International

Association of Surgeons,Gastroenterologists andOncologists; 2011; Tokyo.

35. Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T:

Benefit of tegafur-uracil and leucovorin in chemoradiotherapy for rectal

cancer. Hepatogastroenterology 58(107-108):756-762, 2011

36. Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T,

editors. Therapeutic and adverse effects of preoperative chemoradiotherapy

for rectal cancer. ISW; 2011; Yokohama.

37. Ishihara S, Tamuro H, Yamada H, Nozawa K, Matsuda K, Watanabe T,

editors. Number of lymph nodes in rectal cancer is correlated with response to

preoperative radiotherapy, but is not associated with patient survival. ISW;

2011; Yokohama.

38. Ishihara S, Watanabe T, Akahane T, Shimada R, Horiuchi A, Shibuya H,

Hayama T, Yamada H, Nozawa K, Igaki H, Matsuda K: Prognostic

significance of adverse events associated with preoperative radiotherapy for

rectal cancer. Int J Colorectal Dis 26(7):911-917, 2011

39. Ishihara S, Watanabe T, Nagawa H: Free colonic perforation in a patient with

Crohn's disease and loop ileostomy: report of a case. Int Surg 96(2):159-161,

2011

40. Matsuda K, Akahane T, Horiuchi A, Shimada R, Hayama T, Yamada H,

Nozawa K, Ishihara S, Watanabe T, editors. Examination of IBD cases of

infliximab administration. 21st World Congress of the International


41. Matsuda K, Ishihara S, Watanabe T, editors. Results of treatments for

obstructive colorectal cancer. ISW; 2011; Yokohama.

42. Matsuda K, Ishihara S, Watanabe T, editors. Investigation of rectal carcinoid

treated in our department. ISW; 2011; Yokohama.

43. Nakamura K, Nozawa K, Aoyagi Y, Ishihara S, Matsuda K, Fukushima J,

Watanabe T: A case report of thyroid gland metastasis associated with lung

metastasis from colon cancer. Tumori 97(2):229-232, 2011

44. Nozawa K, Shimada R, Horiuchi A, Hayama T, Yamada H, Ishihara S,

Matsuda K, Watanabe T, editors. A study of a combination therapy using

bevacizumab to metastatic colorectal cancer. ISW; 2011; Yokohama.

45. Shibuya H, Matsuda K, Shimada R, Horiuchi A, Iinuma H, Hayama T,

Yamada H, Nozawa K, Ishihara S, Watanabe T: Invasive micropapillary

carcinoma of the ascending colon--a report of a case. Int Surg 96(1):82-86,

2011

46. Shimada R, Hayama T, Yamazaki N, Akahane T, Horiuchi A, Shibuya H,

Yamada H, Ishihara S, Nozawa K, Matsuda K, Watanabe T: Intestinal

pneumatosis in which CT colonography was of significant diagnostic value:

case report. Int Surg 96(3):217-219, 2011

47. Watanabe T, Ishihara S, Nozawa K, Matsuda K, editors. Preoperative

chemoradiotherapy for rectal cancer. 21st World Congress of the International


48. Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S,

Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T,

Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H: RUNX3 copy

number predicts the development of UC-associated colorectal cancer. Int J

Oncol 38(1):201-207, 2011

49. Watanabe T, Kobunai T, Yamamoto Y, Ikeuchi H, Matsuda K, Ishihara S,

Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T,

Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H: Predicting

ulcerative colitis-associated colorectal cancer using reverse-transcription

polymerase chain reaction analysis. Clin Colorectal Cancer 10(2):134-141,

2011

50. Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K,

Iinuma H, Ikeuchi H: Gene expression of vascular endothelial growth factor

A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in

prediction of response to bevacizumab treatment in colorectal cancer patients.

Dis Colon Rectum 54(8):1026-1035, 2011


Iinuma H, Ikeuchi H, Eshima K: Differential gene expression signatures

between colorectal cancers with and without KRAS mutations: crosstalk

between the KRAS pathway and other signalling pathways. Eur J Cancer

47(13):1946-1954, 2011


Iinuma H, Kanazawa T, Tanaka T, Konishi T, Ikeuchi H, Eshima K, Muto T,

Nagawa H: Gene expression of mesenchyme forkhead 1 (FOXC2)

significantly correlates with the degree of lymph node metastasis in colorectal

cancer. Int Surg 96(3):207-216, 2011


Iinuma H, Konishi T, Horie H, Ikeuchi H, Eshima K, Muto T: Gene

expression signature and response to the use of leucovorin, fluorouracil and

oxaliplatin in colorectal cancer patients. Clin Transl Oncol 13(6):419-425,

2011


Iinuma H, Shibuya H, Eshima K: Heterogeneity of KRAS status may explain

the subset of discordant KRAS status between primary and metastatic

colorectal cancer. Dis Colon Rectum 54(9):1170-1178, 2011

55. Watanabe T, Matsuda K, Ishihara S: Heterogeneous distribution of LOH (loss

of heterozygosity) and tumor progression. Gynecol Oncol 121(3):640; author

reply 640-641, 2011

56. Watanabe T, Matsuda K, Ishihara S, Nozawa K, Hayama T, Yamada H,

Iinuma H: Usefulness of the mononucleotide marker "BAT-26" for

identification of microsatellite instability in colorectal cancers. Asian Pac J

Cancer Prev 12(1):335, 2011


Kobunai T: Letter to the editor: genetic instability in the downregulation of

sFRP1. Anat Rec (Hoboken) 294(8):1283, 2011

58. Yamada H, Akahane T, Horiuchi A, Shimada R, Shibuya H, Hayama T,

Nozawa K, Ishihara S, Matsuda K, Watanabe T: A case of lung squamous cell

carcinoma with metastases to the duodenum and small intestine. Int Surg

96(2):176-181, 2011

59. Yamada H, Ishihara S, Akahane T, Shimada R, Horiuchi A, Shibuya H,

Aoyagi Y, Nakamura K, Iinuma H, Hayama T, Nozawa K, Matsuda K,

Watanabe T: Two cases of diverticulitis in patients with Williams syndrome.

Int Surg 96(1):64-68, 2011

60. Hayama T, Ishihara S, Nozawa K, Matsuda K, Watanabe T: Multi-detector

row computed tomography (MDCT) is useful for the diagnosis of rectal

varices. Tech Coloproctol 16(3):265-266, 2012

61. Ishihara S, Iinuma H, Fukushima Y, Akahane T, Horiuchi A, Shimada R,

Shibuya H, Hayama T, Yamada H, Nozawa K, Matsuda K, Watanabe T:

Radiation-induced apoptosis of peripheral blood lymphocytes is correlated

with histological regression of rectal cancer in response to preoperative

chemoradiotherapy. Ann Surg Oncol 19(4):1192-1198, 2012

62. Ishihara S, Watanabe T, Akahane T, Shimada R, Horiuchi A, Shibuya H,

Hayama T, Yamada H, Nozawa K, Matsuda K, Maeda K, Sugihara K: Tumor

location is a prognostic factor in poorly differentiated adenocarcinoma,

mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon. Int J

Colorectal Dis 27(3):371-379, 2012


Yamada H, Hayama T, Inoue E, Tamura J, Iinuma H, Akiyoshi T, Muto T:

Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts

survival for colorectal cancer. J Clin Oncol 30(18):2256-2264, 2012


Iinuma H: Significance of microsatellite instability (MSI) for colorectal

cancer following adjuvant therapy with doxifluridine. Med Oncol 29(1):133,

2012

65. Noda M, Ishihara S, editors. A multicenter phase I study on preoperative

chemoradiotherapy with S-1 and CPT-11 for locally advanced lower rectal

cancer (SAMRAI-1). 2013 ASCO Annual Meeting; 2013; Chicago.

66. Abe S, Yamaguchi H, Murono K, Kanazawa T, Ishihara S, Sunami E,

Watanabe T: Passage of a sigmoid colon cast in a patient with ischemic colitis.

Int Surg 99(5):500-505, 2014

67. Emoto S, Sunami E, Yamaguchi H, Ishihara S, Kitayama J, Watanabe T:

Drug development for intraperitoneal chemotherapy against peritoneal

carcinomatosis from gastrointestinal cancer. Surg Today 44(12):2209-2220,

2014

68. Iida Y, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J,

Watanabe T: Proximal shift of colorectal cancer along with aging. Clin

Colorectal Cancer 13(4):213-218, 2014

69. Iida Y, N HT, Kishikawa J, Kaneko K, Murono K, Kawai K, Ikeda T,

Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Yatomi Y, Watanabe T:

Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer

cells through GPR34 and PI3K/Akt pathway. Anticancer Res

34(10):5465-5472, 2014

70. Iida Y, Sunami E, Ishihara S, Yamaguchi H, Kitayama J, Tsuno N, Watanabe

T, editors. Phosphatidylserine specific Phospholipase A1 (PSPLA1)

Expression in Colorectal Cancer correlates with Tumor Invasion and

Hematogenous Metastasis. American Association for Cancer Research

Annual Meeting; 2014; San Diego.

71. Ishihara S, Fukushima Y, Akahane T, Horiuchi A, Shimada R, Nakamura K,

Aoyagi Y, Hayama T, Yamada H, Nozawa K, Matsuda K, Hashiguchi Y,

Watanabe T: Number of Lymph Nodes in Rectal Cancer is Correlated with

Response to Preoperative Chemoradiotherapy but is not Associated with

Patient Survival. Hepatogastroenterology 61(132):1000-1007, 2014

72. Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Miyata H,

Yoneyama S, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H,

Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y,

Sugihara K, Watanabe T: Prognostic impact of primary tumor resection and

lymph node dissection in stage IV colorectal cancer with unresectable

metastasis: a propensity score analysis in a multicenter retrospective study.

Ann Surg Oncol 21(9):2949-2955, 2014

73. Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K,

Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J,

Hashiguchi Y, Sugihara K, Watanabe T: Prognostic impact of tumor location

in stage IV colon cancer: a propensity score analysis in a multicenter study.

Int J Surg 12(9):925-930, 2014

74. Ishihara S, Watanabe T, Fukushima Y, Akahane T, Horiuchi A, Shimada R,

Nakamura K, Hayama T, Yamada H, Nozawa K, Matsuda K, Hashiguchi Y:

Safety and factors contributing to the difficulty of laparoscopic surgery for

rectal cancer treated with preoperative chemoradiotherapy. Tech Coloproctol

18(3):247-255, 2014

75. Kawai K, Sunami E, Nishikawa T, Tanaka J, Tanaka T, Kiyomatsu T, Hata K,

Nozawa H, Kazama S, Ishihara S, Yamaguchi H, Kitayama J, Watanabe T:

Delayed abdominal wall abscess after abdomino-perineal resection simulating

local recurrence of rectal cancer. Springerplus 3:681, 2014

76. Murono K, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Barium enema and CT volumetry for predicting

pathologic response to preoperative chemoradiotherapy in rectal cancer

patients. Dis Colon Rectum 57(6):715-724, 2014

77. Nozawa H, Kanazawa T, Tanaka T, Takahashi M, Ishihara S, Sunami E,

Kitayama J, Ikemura M, Komuro I, Watanabe T: Laparoscopic resection of a

gastrointestinal stromal tumor of the lower rectum in a patient with coronary

artery disease following long-term neoadjuvant imatinib treatment and

anticoagulation therapy. World J Surg Oncol 12(1):211, 2014

78. Nozawa H, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata

K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T:

'Deepness of Response' Is Associated with Overall Survival in Standard

Systemic Chemotherapy for Metastatic Colorectal Cancer. Chemotherapy

60(5-6):360-367, 2014

79. Ozawa T, Kazama S, Akiyoshi T, Murono K, Yoneyama S, Tanaka T, Tanaka

J, Kiyomatsu T, Kawai K, Nozawa H, Kanazawa T, Yamaguchi H, Ishihara S,

Sunami E, Kitayama J, Morikawa T, Fukayama M, Watanabe T: Nuclear

Notch3 expression is associated with tumor recurrence in patients with stage

II and III colorectal cancer. Ann Surg Oncol 21(8):2650-2658, 2014

80. Sakai K, Kazama S, Nagai Y, Murono K, Tanaka T, Ishihara S, Sunami E,

Tomida S, Nishio K, Watanabe T: Chemoradiation provides a physiological

selective pressure that increases the expansion of aberrant TP53 tumor

variants in residual rectal cancerous regions. Oncotarget 5(20):9641-9649,

2014

81. Shibata J, Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K,

Kawai K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E,

Watanabe T: [Minimally invasive surgery for rectal cancer]. Nihon

Shokakibyo Gakkai Zasshi 111(11):2105-2112, 2014

82. Tada N, Tsuno NH, Kawai K, Murono K, Nirei T, Ishihara S, Sunami E,

Kitayama J, Watanabe T: Changes in the plasma levels of

cytokines/chemokines for predicting the response to chemoradiation therapy

in rectal cancer patients. Oncol Rep 31(1):463-471, 2014

83. Watanabe T, Kobunai T, Akiyoshi T, Matsuda K, Ishihara S, Nozawa K:

Prediction of response to preoperative chemoradiotherapy in rectal cancer by

using reverse transcriptase polymerase chain reaction analysis of four genes.

Dis Colon Rectum 57(1):23-31, 2014

1. 84. Watanabe T, Matsusaka S, Ishihara S, Kondo K, Horie H, Uehara K,

Oguchi M, Murofushi K, Ueno M, Muzunuma N, Kato D, Hashiguchi Y,

Shimbo T, Okuda J, Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada

T, Ishikawa Y, editors. A phase I/II study of S-1 plus oxaliplatin combined

with radiation (SOX/RT) for preoperative locally advanced rectal

carcinoma (JACCRO CC-04: SHOGUN trial). ASCO-GI 2014（2014

Gastrointestinal Cancers Symposium）; 2014; San Francisco.

84. Yokoyama Y, Kawai K, Kazama S, Yoneyama S, Tanaka J, Tanaka T,

Kiyomatsu T, Nozawa H, Kanazawa T, Yamaguchi H, Ishihara S, Sunami E,

Kitayama J, Watanabe T: A case of extraperitoneal stoma-associated internal

hernia after abdominoperineal resection. World J Surg Oncol 12(1):141, 2014

85. Anzai H, Kazama S, Kiyomatsu T, Nishikawa T, Tanaka T, Tanaka J, Hata K,

Kawai K, Yamaguchi H, Nozawa H, Kanazawa T, Ushiku T, Ishihara S,

Sunami E, Fukayama M, Watanabe T: Alpha-fetoprotein-producing early

rectal carcinoma: a rare case report and review. World J Surg Oncol 13(1):180,

2015

86. Hata K, Ishihara S, Watanabe T: Successful Surveillance Colonoscopy for

Patients with Ulcerative Colitis After Ileorectal Anastomosis. J Crohns Colitis

9(10):937-938, 2015

87. Hata K, Kazama S, Nozawa H, Kawai K, Kiyomatsu T, Tanaka J, Tanaka T,

Nishikawa T, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T:

Laparoscopic surgery for ulcerative colitis: a review of the literature. Surg

Today 45(8):933-938, 2015

88. Hiyoshi M, Kawai K, Shibuya M, Ozawa T, Kishikawa J, Nirei T, Tanaka T,

Tanaka J, Kiyomatsu T, Tada T, Kanazawa T, Kazama S, Shoda H,

Sumitomo S, Kubo K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J,

Yamamoto K, Watanabe T: Tracheobronchitis with dyspnea in a patient with

ulcerative colitis. Intern Med 54(7):749-753, 2015

89. Hongo K, Kazama S, Tsuno NH, Ishihara S, Sunami E, Kitayama J,

Watanabe T: Immunohistochemical detection of high-mobility group box 1

correlates with resistance of preoperative chemoradiotherapy for lower rectal

cancer: a retrospective study. World J Surg Oncol 13(1):7, 2015

90. Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue

A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T:

Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in

colorectal cancer correlates with tumor invasion and hematogenous metastasis.

Anticancer Res 35(3):1459-1464, 2015

91. Ishihara S, Matsuda K, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa

H, Kazama S, Kanazawa T, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi

Y, Watanabe T: Patient factors predisposing to complications following

laparoscopic surgery for colorectal cancers. Surg Laparosc Endosc Percutan

Tech 25(2):168-172, 2015

92. Ishihara S, Matsusaka S, Kondo K, Horie H, Uehara K, Oguchi M, Murofushi

K, Ueno M, Mizunuma N, Shinbo T, Kato D, Okuda J, Hashiguchi Y,

Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y,

Nakajima T, Watanabe T: A phase I dose escalation study of oxaliplatin plus

oral S-1 and pelvic radiation in patients with locally advanced rectal cancer

(SHOGUN trial). Radiat Oncol 10(1):24, 2015

93. Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K,

Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Sugihara K,

Watanabe T: Benefit of primary tumor resection in stage IV colorectal cancer

with unresectable metastasis: a multicenter retrospective study using a

propensity score analysis. Int J Colorectal Dis 30(6):807-812, 2015

94. Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka J, Tanaka T, Kiyomatsu

T, Hata K, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Recent advances in robotic surgery for rectal cancer.

Int J Clin Oncol 20(4):633-640, 2015

95. Ishii H, Kawai K, Hata K, Shuno Y, Nishikawa T, Tanaka T, Tanaka J,

Kiyomatsu T, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E,

Kitayama J, Watanabe T: Comparison of Functional Outcomes of Patients

Who Underwent Hand-Sewn or Stapled Ileal Pouch-Anal Anastomosis for

Ulcerative Colitis. Int Surg 100(7-8):1169-1176, 2015

96. Kaneko K, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E,

Watanabe T: Perioperative Allogeneic Blood Transfusion Is Associated With

Surgical Site Infection After Abdominoperineal Resection-a Space for the

Implementation of Patient Blood Management Strategies. Int Surg

100(5):797-804, 2015

97. Kawai K, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Miyata H,

Sugihara K, Watanabe T: Nomograms for predicting the prognosis of stage IV

colorectal cancer after curative resection: a multicenter retrospective study.

Eur J Surg Oncol 41(4):457-465, 2015

98. Kawai K, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Miyata H,

Watanabe T: Nomogram prediction of metachronous colorectal neoplasms in

patients with colorectal cancer. Ann Surg 261(5):926-932, 2015

99. Kawai K, Sunami E, Tanaka J, Tanaka T, Kiyomatsu T, Nozawa H, Kazama

S, Kanazawa T, Hosaka A, Ishihara S, Yamaguchi H, Shigematsu K,

Watanabe T: Synchronous colorectal malignancy and abdominal aortic

aneurysm treated with endovascular aneurysm repair followed by

laparoscopic colectomy. Int Surg 100(4):600-603, 2015

100. Kawai K, Sunami E, Yamaguchi H, Ishihara S, Kazama S, Nozawa H, Hata K,

Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Kitayama J, Watanabe T:

Nomograms for colorectal cancer: A systematic review. World J

Gastroenterol 21(41):11877-11886, 2015

101. Kazama S, Kishikawa J, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka

J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S,

Sunami E, Watanabe T: CD133 Expression in Lymph Node Metastases Is

Associated with Tumor Aggressiveness During Lymph Node Metastasis in

Colorectal Cancer. Anticancer Res 35(12):6599-6605, 2015

102. Kazama S, Kitayama J, Hiyoshi M, Taketomi Y, Murakami M, Nishikawa T,

Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Yamaguchi H, Nozawa

H, Ishihara S, Sunami E, Watanabe T: Phospholipase A2 Group III and Group

X Have Opposing Associations with Prognosis in Colorectal Cancer.

Anticancer Res 35(5):2983-2990, 2015

103. Kishikawa J, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E,

Watanabe T: Characteristics and prognosis of colorectal cancer associated

with rheumatic disease. Int Surg 100(5):783-789, 2015

104. Kiyomatsu H, Kawai K, Tanaka T, Tanaka J, Kiyomatsu T, Nozawa H,

Kanazawa T, Kazama S, Ishihara S, Yamaguchi H, Sunami E, Watanabe T:

Mesalazine-induced Pleuropericarditis in a Patient with Crohn's Disease.

Intern Med 54(13):1605-1608, 2015

105. Matsusaka S, Ishihara S, Kondo K, Horie H, Uehara K, Oguchi M, Murofushi

K, Ueno M, Mizunuma N, Shimbo T, Kato D, Okuda J, Hashiguchi Y,

Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y,

Nakajima T, Watanabe T: A multicenter phase II study of preoperative

chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal

cancer (SHOGUN trial). Radiother Oncol 116(2):209-213, 2015

106. Murono K, Kawai K, Kazama S, Ishihara S, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Anatomy of the inferior mesenteric artery evaluated

using 3-dimensional CT angiography. Dis Colon Rectum 58(2):214-219, 2015

107. Murono K, Kazama S, Yamaguchi H, Kawai K, Ishihara S, Sunami E,

Kitayama J, Satoh Y, Kurihara M, Yatomi Y, Watanabe T: Detection of

carcinoembryonic antigen mRNA in peritoneal lavage by the

transcription-reverse transcription concerted method indicates poor prognosis

in patients with stage II and III colon cancer. Surgery 157(2):322-330, 2015

108. Nagai Y, Yamamoto Y, Yasuhara T, Hata K, Nishikawa T, Tanaka T, Tanaka

J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S,

Sunami E, Yamanaka T, Miyagawa K, Watanabe T: High RAD54B

expression: an independent predictor of postoperative distant recurrence in

colorectal cancer patients. Oncotarget 6(25):21064-21073, 2015

109. Nirei T, Kazama S, Hiyoshi M, Tsuno NH, Nishikawa T, Tanaka T, Tanaka J,

Kiyomatsu T, Hata K, Kawai K, Nozawa H, Kanazawa T, Yamaguchi H,

Ishihara S, Sunami E, Kitayama J, Watanabe T: Successful treatment of

rectovaginal fistula complicating ulcerative colitis with infliximab: a case

report and review of the literature. J Clin Med Res 7(1):59-61, 2015

110. Nishikawa T, Sunami E, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K,

Kazama S, Nozawa H, Ishihara S, Watanabe T: Incidence and prognostic

significance of positive peritoneal lavage in colorectal cancer. Surg Today

45(9):1073-1081, 2015

111. Nozawa H, Ishihara S, Morikawa T, Tanaka J, Yasuda K, Ohtani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Kazama S,

Yamaguchi H, Sunami E, Kitayama J, Fukayama M, Watanabe T:

Metachronous tubulovillous and tubular adenomas of the anal canal. Diagn

Pathol 10(1):139, 2015

112. Nozawa H, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata

K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T:

Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant

Chemotherapy Using Oxaliplatin. Anticancer Res 35(9):5073-5078, 2015

113. Nozawa H, Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata

K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Nakajima J,

Kokudo N, Watanabe T: Predictors and outcome of complete removal of

colorectal cancer with synchronous lung metastases. Mol Clin Oncol

3(5):1041-1047, 2015

114. Ozawa T, Ishihara S, Kawai K, Kazama S, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Impact of a lymphocyte to monocyte ratio in stage

IV colorectal cancer. J Surg Res 199(2):386-392, 2015

115. Ozawa T, Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K,

Kawai K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Prognostic significance of the lymph node ratio in

stage IV colorectal cancer patients who have undergone curative resection.

Ann Surg Oncol 22(5):1513-1519, 2015

116. Ozawa T, Ishihara S, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K,

Kawai K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J,

Watanabe T: The preoperative platelet to lymphocyte ratio is a prognostic

marker in patients with stage II colorectal cancer. Int J Colorectal Dis

30(9):1165-1171, 2015

117. Ozawa T, Ishihara S, Sunami E, Kitayama J, Watanabe T: Log odds of

positive lymph nodes as a prognostic indicator in stage IV colorectal cancer

patients undergoing curative resection. J Surg Oncol 111(4):465-471, 2015

118. Ozawa T, Ishihara S, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Kanazawa

T, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T:

Clinical Characteristics and Postoperative Complications of Patients

Undergoing Emergency Surgery for Ulcerative Colitis.

Hepatogastroenterology 62(140):853-858, 2015

119. Ozawa T, Yamaguchi H, Kiyomatsu T, Saito S, Ishihara S, Sunami E,

Kitayama J, Watanabe T: A case report of idiopathic systemic capillary leak

syndrome that occurred during the postoperative period of abdominoperineal

resection for colorectal cancer. Int Surg 100(1):58-62, 2015

120. Shibata J, Ishihara S, Tada N, Kawai K, Tsuno NH, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Surgical stress response after colorectal resection: a

comparison of robotic, laparoscopic, and open surgery. Tech Coloproctol

19(5):275-280, 2015

121. Shibata J, Kawai K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K,

Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J,

Sugihara K, Watanabe T: Prognostic Impact of Histologic Type in Curatively

Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective

Study. Ann Surg Oncol 22 Suppl 3:S621-629, 2015

122. Tada N, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama

J, Oba K, Watanabe T: Prediction of the preoperative chemoradiotherapy

response for rectal cancer by peripheral blood lymphocyte subsets. World J

Surg Oncol 13:30, 2015

123. Takiyama H, Kazama S, Tanoue Y, Yasuda K, Otani K, Nishikawa T, Tanaka

T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Miyagawa T,

Yamada D, Yamaguchi H, Ishihara S, Sunami E, Watanabe T: Efficacy of

magnetic resonance imaging in the diagnosis of perianal hidradenitis

suppurativa, complicated by anal fistulae: A report of two cases and review of

the literature. Int J Surg Case Rep 15:107-111, 2015

124. Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Kazama S,

Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T:

Analysis of anastomotic leakage after rectal surgery: A case-control study.

Ann Med Surg (Lond) 4(2):183-186, 2015

125. Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi

T, Hyodo I, Igarashi M, Ishida H, Ishihara S, Ishiguro M, Kanemitsu Y,

Kokudo N, Muro K, Ochiai A, Oguchi M, Ohkura Y, Saito Y, Sakai Y, Ueno

H, Yoshino T, Boku N, Fujimori T, Koinuma N, Morita T, Nishimura G,

Sakata Y, Takahashi K, Tsuruta O, Yamaguchi T, Yoshida M, Yamaguchi N,

Kotake K, Sugihara K, Japanese Society for Cancer of the C, Rectum:

Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines

2014 for treatment of colorectal cancer. Int J Clin Oncol 20(2):207-239, 2015

126. Yamaguchi H, Kitayama J, Ishigami H, Kazama S, Nozawa H, Kawai K, Hata

K, Kiyomatsu T, Tanaka T, Tanaka J, Nishikawa T, Otani K, Yasuda K,

Ishihara S, Sunami E, Watanabe T: Breakthrough therapy for peritoneal

carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes.

World J Gastrointest Oncol 7(11):285-291, 2015

127. Yokoyama Y, Hata K, Kanazawa T, Yamaguchi H, Ishihara S, Sunami E,

Kitayama J, Watanabe T: Giant solitary fibrous tumor of the pelvis

successfully treated with preoperative embolization and surgical resection: a

case report. World J Surg Oncol 13:164, 2015

128. Abe S, Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T, Tanaka T,

Watanabe T: Prognostic impact of carcinoembryonic antigen and

carbohydrate antigen 19-9 in stage IV colorectal cancer patients after R0

resection. J Surg Res 205(2):384-392, 2016

129. Anzai H, Hata K, Kishikawa J, Ishii H, Nishikawa T, Tanaka T, Tanaka J,

Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S,

Sunami E, Kitayama J, Watanabe T: Clinical pattern and progression of

ulcerative proctitis in the Japanese population: a retrospective study of

incidence and risk factors influencing progression. Colorectal Dis

18(3):O97-O102, 2016

130. Anzai H, Hata K, Kishikawa J, Ishii H, Yasuda K, Otani K, Nishikawa T,

Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H,

Ishihara S, Sunami E, Watanabe T: Appendiceal orifice inflammation is

associated with proximal extension of disease in patients with ulcerative

colitis. Colorectal Dis 18(8):O278-282, 2016

131. Arakawa K, Ishihara S, Kawai K, Shibata J, Otani K, Yasuda K, Nishikawa T,

Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Yamaguchi H, Sunami E,

Kitayama J, Watanabe T: Asynchronous bilateral anastomosis site sigmoid

colon cancer after ureterosigmoidostomy: a case report. World J Surg Oncol

14(1):180, 2016

132. Arakawa K, Kiyomatsu T, Ishihara S, Ikemura M, Hojo D, Takiyama H,

Murono K, Otani K, Yasuda K, Nishikawa T, Tanaka T, Kawai K, Hata K,

Nozawa H, Yamaguchi H, Watanabe T: A case report of anorectal malignant

melanoma with mucosal skipped lesion. Int J Surg Case Rep 24:206-210,

2016

133. Hata K, Anzai H, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Watanabe T,

editors. THE RISK FACTOR FOR THE DEVELOPMENT OF POUCHITIS

AFTER TOTAL PROCTOCOLECTOMY AND ILEAL POUCH-ANAL

ANASTOMO- SIS IN PATIENTS WITH ULCERATIVE COLITIS;

META-ANALYSIS. ASCRS; 2016.

134. Hata K, Ishihara S, Watanabe T: Diagnosis and treatment for colitis

associated cancer. Nihon Shokakibyo Gakkai Zasshi 113(3):430-438, 2016

135. Hata K, Kishikawa J, Anzai H, Shinagawa T, Kazama S, Ishii H, Nozawa H,

Kawai K, Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Otani K, Yasuda

K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T:

Surveillance colonoscopy for colitis-associated dysplasia and cancer in

ulcerative colitis patients. Dig Endosc 28(3):260-265, 2016

136. Hata K, Yamamoto Y, Kiyomatsu T, Tanaka T, Kazama S, Nozawa H, Kawai

K, Tanaka J, Nishikawa T, Otani K, Yasuda K, Kishikawa J, Nagai Y, Anzai

H, Shinagawa T, Arakawa K, Yamaguchi H, Ishihara S, Sunami E, Kitayama

J, Watanabe T: Hereditary gastrointestinal cancer. Surg Today

46(10):1115-1122, 2016

137. Ishihara S, Kanemitsu Y, Murono K, Otani K, Yasuda K, Nishikawa T,

Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S,

Yamaguchi H, Sunami E, Sugihara K, Watanabe T: Oncological benefit of

lateral pelvic lymph node dissection for rectal cancer treated without

preoperative chemoradiotherapy: a multicenter retrospective study using

propensity score analysis. Int J Colorectal Dis 31(7):1315-1321, 2016

138. Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu

T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E,

Kitayama J, Sugihara K, Watanabe T: Prognostic impact of lymph node

dissection is different for male and female colon cancer patients: a propensity

score analysis in a multicenter retrospective study. Int J Colorectal Dis

31(6):1149-1155, 2016

139. Ishii H, Hata K, Kishikawa J, Anzai H, Otani K, Yasuda K, Nishikawa T,

Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S,

Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T: Incidence of

neoplasias and effectiveness of postoperative surveillance endoscopy for

patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal

pouch-anal anastomosis. World J Surg Oncol 14(1):75, 2016

140. Kawai K, Iida Y, Ishihara S, Yamaguchi H, Nozawa H, Hata K, Kiyomatsu T,

Tanaka T, Nishikawa T, Yasuda K, Otani K, Murono K, Watanabe T:

Intraoperative colonoscopy in patients with colorectal cancer: Review of

recent developments. Dig Endosc 28(6):633-640, 2016

141. Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T, Tanaka T, Nishikawa

T, Otani K, Yasuda K, Murono K, Sasaki K, Watanabe T: Survival Impact of

Extracolorectal Malignancies in Colorectal Cancer Patients. Digestion

94(2):92-99, 2016

142. Kishikawa J, Kazama S, Oba K, Hasegawa K, Anzai H, Harada Y, Abe H,

Matsusaka K, Hongo K, Oba M, Yasuda K, Otani K, Nishikawa T, Tanaka T,

Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Yamaguchi H, Ishihara

S, Sunami E, Ushiku T, Kitayama J, Fukayama M, Kokudo N, Watanabe T:

CD133 Expression at the Metastatic Site Predicts Patients' Outcome in

Colorectal Cancer with Synchronous Liver Metastasis. Ann Surg Oncol

23(6):1916-1923, 2016

143. Matsuzaki H, Ishihara S, Kawai K, Nishikawa T, Tanaka T, Kiyomatsu T,

Hata K, Nozawa H, Yamada S, Watanabe T: Late sacral recurrence of rectal

cancer treated by heavy ion radiotherapy: a case report. Surg Case Rep

2(1):109, 2016

144. Murono K, Kawai K, Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T,

Kiyomatsu T, Hata K, Nozawa H, Yamaguchi H, Watanabe T: Evaluation of

the vascular anatomy of the right-sided colon using three-dimensional

computed tomography angiography: a single-center study of 536 patients and

a review of the literature. Int J Colorectal Dis 31(9):1633-1638, 2016

145. Nagai Y, Hata K, Kawai K, Murono K, Yasuda K, Otani K, Nishikawa T,

Tanaka T, Kiyomatsu T, Nozawa H, Yamaguchi H, Ishihara S, Watanabe T:

Clinicopathological Features of Colorectal Cancer Patients Under the Age of

50: Recent Experience and Case-Control Study of Prognosis in a Japanese

Cohort. Digestion 93(4):272-279, 2016

146. Nagai Y, Kazama S, Yamada D, Miyagawa T, Murono K, Yasuda K,

Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Masui Y, Nozawa H,

Yamaguchi H, Ishihara S, Kadono T, Watanabe T: Perianal and Vulvar

Extramammary Paget Disease: A Report of Six Cases and Mapping Biopsy of

the Anal Canal. Ann Dermatol 28(5):624-628, 2016

147. Nagata H, Kondo Y, Kawai K, Ishihara S, Kazama S, Nirei T, Soma D,

Yamada J, Sunami E, Kitayama J, Kubota Y, Watanabe T: A giant mucinous

cystadenocarcinoma of the appendix: a case report and review of the literature.

World J Surg Oncol 14(1):64, 2016

148. Nishikawa T, Hata K, Yoshida S, Murono K, Yasuda K, Otani K, Tanaka T,

Kiyomatsu T, Kawai K, Nozawa H, Ishihara S, Koike K, Watanabe T:

Successful endoscopic treatment of stapled J-pouch ileoanal canal

anastomotic hemorrhage by argon plasma coagulation: a case report. J Med

Case Rep 10(1):309, 2016

149. Nishikawa T, Ishihara S, Hata K, Murono K, Yasuda K, Otani K, Tanaka T,

Kiyomatsu T, Kawai K, Nozawa H, Yamaguchi H, Watanabe T: Short-term

outcomes of open versus laparoscopic surgery in elderly patients with

colorectal cancer. Surg Endosc 30(12):5550-5557, 2016

150. Nishikawa T, Ishihara S, Ushiku T, Hata K, Sasaki K, Murono K, Yasuda K,

Otani K, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Watanabe T: Anal

metastasis from rectal adenocarcinoma. Clin J Gastroenterol 9(6):379-383,

2016

151. Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K,

Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S,

Sunami E, Kitayama J, Watanabe T: Outcome of salvage surgery for

colorectal cancer initially treated by upfront endoscopic therapy. Surgery

159(3):713-720, 2016

152. Nozawa H, Ishihara S, Kawai K, Murono K, Yasuda K, Otani K, Nishikawa T,

Tanaka T, Kiyomatsu T, Hata K, Watanabe T: Paradoxical Reductions in

Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable

Colorectal Cancer: An Observational Study. Oncology 91(3):127-134, 2016

153. Nozawa H, Ishihara S, Murono K, Yasuda K, Otani K, Nishikawa T, Tanaka

T, Kiyomatsu T, Hata K, Kawai K, Yamaguchi H, Watanabe T:

Laparoscopy-assisted versus open surgery for multiple colorectal cancers with

two anastomoses: a cohort study. Springerplus 5:287, 2016

154. Okuno T, Yamaguchi H, Kitayama J, Ishigami H, Nishikawa T, Tanaka J,

Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Kawai K, Kazama S, Ishihara S,

Sunami E, Watanabe T: A case of disseminated carcinomatosis of the bone

marrow originating from gastric cancer 3 years after intraperitoneal

chemotherapy against peritoneal carcinomatosis. World J Surg Oncol

14(1):107, 2016

155. Ota Y, Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J,

Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H,

Sunami E, Kitayama J, Watanabe T: Effect of nutrient starvation on

proliferation and cytokine secretion of peripheral blood lymphocytes. Mol

Clin Oncol 4(4):607-610, 2016

156. Otani K, Ishihara S, Hata K, Murono K, Sasaki K, Yasuda K, Nishikawa T,

Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Yamaguchi H, Watanabe T:

Colorectal cancer with venous tumor thrombosis. Asian J Surg 2016

157. Ozawa T, Ishihara S, Kawai K, Nozawa H, Yamaguchi H, Kitayama J,

Watanabe T: Prognostic Significance of Preoperative Serum Carbohydrate

Antigen 19-9 in Patients With Stage IV Colorectal Cancer. Clin Colorectal

Cancer 15(4):e157-e163, 2016

158. Saito H, Hanafusa N, Kishikawa J, Noiri E, Sunami E, Ishihara S, Watanabe

T, Nangaku M: Ulcerative colitis with hepatitis B virus infection treated

successfully by granulocyte monocyte apheresis. J Clin Apher 31(6):584-586,

2016

159. Tachikawa Y, Nozawa H, Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T,

Hata K, Kawai K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama

J, Fujisawa M, Takahashi K, Sakaguchi Y, Ushiku T, Fukayama M,

Watanabe T: Colonic perforation in a patient with systemic lupus

erythematosus accompanied by cytomegalovirus infection: A case report. Int J

Surg Case Rep 23:70-73, 2016

160. Takiyama A, Nozawa H, Ishihara S, Takiyama H, Murono K, Yasuda K,

Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Watanabe

T: Secondary metastasis in the lymph node of the bowel invaded by colon

cancer: a report of three cases. World J Surg Oncol 14(1):273, 2016

161. Tanaka T, Kawai K, Abe H, Murono K, Otani K, Nishikawa T, Kiyomatsu T,

Hata K, Nozawa H, Yamaguchi H, Ishihara S, Fukayama M, Watanabe T:

Giant mucocele of the colon at the distal stump due to low-grade mucinous

neoplasia. Surg Case Rep 2(1):117, 2016

162. Watanabe T, Ishihara S, Kawai K, Nozawa H, Hata K, Kiyomatsu T, Sunami

E, editors. ROBOTIC SURGERY FOR RECTAL CANCER AND

LATERAL LYMPH

2. NODE DISSECTION. ASCRS; 2016.

163. Yamaguchi H, Kitayama J, Ishigami H, Emoto S, Nishikawa T, Tanaka J,

Tanaka T, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Ishihara S,

Sunami E, Watanabe T: A patient with gastric cancer with peritoneal

carcinomatosis treated with intraperitoneal chemotherapy who survived more

than 5 years receiving repeated laparoscopic examinations: a case report. J

Med Case Rep 10(1):14, 2016

164. Yasuda K, Kawai K, Ishihara S, Murono K, Otani K, Nishikawa T, Tanaka T,

Kiyomatsu T, Hata K, Nozawa H, Yamaguchi H, Aoki S, Mishima H,

Maruyama T, Sako A, Watanabe T: Level of arterial ligation in sigmoid colon

and rectal cancer surgery. World J Surg Oncol 14(1):99, 2016

165. Yoshioka Y, Nozawa H, Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T,

Kawai K, Hata K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama

J, Watanabe T: Small bowel adenocarcinoma arising in a patient with

hereditary hemorrhagic telangiectasia: A case report. Oncol Lett

11(3):2137-2139, 2016

166. Abe S, Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T, Tanaka T,

Nishikawa T, Ootani K, Yasuda K, Murono K, Watanabe T: Prognostic Value

of Pre- and Postoperative Anti-p53 Antibody Levels in Colorectal Cancer

Patients: A Retrospective Study. Oncology 92(1):31-38, 2017

167. Anzai H, Hata K, Ishihara S, Osada T, Kiyomatsu T, Kawai K, Nozawa H,

Watanabe T: Caution Against the Resect-and-Discard Strategy for Dysplastic

Polyps in Ulcerative Colitis. Am J Gastroenterol 112(1):189-191, 2017

168. Anzai H, Ishihara S, Kiyomatsu T, Kishikawa J, Yasuda K, Otani K,

Nishikawa T, Tanaka T, Hata K, Kawai K, Nozawa H, Watanabe T:

Robot-Assisted Restorative Porctocolectomy and Ileal Pouch-Anal

Anastomosis for Ulcerative Colitis (video article). Journal of Laparoscopic &

Advanced Surgical Techniques 27(4)2017

169. Anzai H, Nozawa H, Tanaka J, Yasuda K, Otani K, Nishikawa T, Tanaka T,

Kiyomatsu T, Hata K, Kawai K, Ushiku T, Ishihara S, Takano T, Fukayama

M, Watanabe T: Giant leiomyosarcoma of the rectum with lymph node

metastasis: A case report and review of the literature. Int J Surg Case Rep

34:27-31, 2017

170. Arakawa K, Kawai K, Ishihara S, Hata K, Nozawa H, Oba K, Sugihara K,

Watanabe T: Prognostic Significance of Peritoneal Metastasis in Stage IV

Colorectal Cancer Patients With R0 Resection: A Multicenter, Retrospective

Study. Dis Colon Rectum 60(10):1041-1049, 2017

171. Emoto S, Ishigami H, Yamaguchi H, Ishihara S, Sunami E, Kitayama J,

Watanabe T: Port-site metastasis after laparoscopic surgery for

gastrointestinal cancer. Surg Today 47(3):280-283, 2017

172. Harada Y, Kazama S, Morikawa T, Murono K, Yasuda K, Otani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Nozawa H,

Yamaguchi H, Ishihara S, Watanabe T: Leucine-rich repeat-containing G

protein-coupled receptor 5 and CD133 expression is associated with tumor

progression and resistance to preoperative chemoradiotherapy in low rectal

cancer. Oncol Lett 14(6):7791-7798, 2017

173. Hata K, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Tanaka T, Kishikawa

J, Anzai H, Watanabe T: Pouchitis after ileal pouch-anal anastomosis in

ulcerative colitis: Diagnosis, management, risk factors, and incidence. Dig

Endosc 29(1):26-34, 2017

174. Hata K, Ishii H, Anzai H, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T,

Watanabe T: Preoperative Extraintestinal Manifestations Associated with

Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal

Pouch-anal Anastomosis: A Retrospective Study. Inflamm Bowel Dis

23(6):1019-1024, 2017

175. Ishihara S, Kawai K, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa

T, Watanabe T: Oncological Outcomes of Lateral Pelvic Lymph Node

Metastasis in Rectal Cancer Treated With Preoperative Chemoradiotherapy.

Dis Colon Rectum 60(5):469-476, 2017

176. Kaneko K, Kawai K, Kazama S, Murono K, Sasaki K, Yasuda K, Ohtani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Ishihara S,

Morikawa T, Fukayama M, Watanabe T: Clinical significance of mucinous

components in rectal cancer after preoperative chemoradiotherapy. Surg

Today 47(6):697-704, 2017

177. Kaneko M, Ishihara S, Murono K, Sasaki K, Otani K, Yasuda K, Nishikawa T,

Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Nakayama H,

Watanabe T, Sasaki S, Watanabe T: Carbohydrate Antigen 19-9 Predicts

Synchronous Peritoneal Carcinomatosis in Patients with Colorectal Cancer.

Anticancer Res 37(2):865-870, 2017

178. Kaneko M, Kawai K, Murono K, Nishikawa T, Sasaki K, Otani K, Yasuda K,

Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Ishihara S, Hayashi A,

Shinozaki-Ushiku A, Fukayama M, Watanabe T: Giant gastrointestinal

stromal tumor of the vermiform appendix: A case report. Mol Clin Oncol

7(3):399-403, 2017

179. Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T, Morikawa T,

Fukayama M, Watanabe T: Prediction of Pathological Complete Response

Using Endoscopic Findings and Outcomes of Patients Who Underwent

Watchful Waiting After Chemoradiotherapy for Rectal Cancer. Dis Colon

Rectum 60(4):368-375, 2017

180. Kawai K, Ishihara S, Nozawa H, Hata K, Kiyomatsu T, Tanaka T, Nishikawa

M, Otani K, Yasuda K, Murono K, Sasaki K, Watanabe T: Recent advances

in neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Journal

of the Anus, Rectum and Colon 1(2):39-44, 2017

181. Kazama S, Kishikawa J, Kiyomatsu T, Kawai K, Nozawa H, Ishihara S,

Watanabe T: Expression of the stem cell marker CD133 is related to tumor

development in colorectal carcinogenesis. Asian J Surg 2017

182. Kiyomatsu T, Ishihara S, Murono K, Otani K, Yasuda K, Nishikawa T,

Tanaka T, Hata K, Kawai K, Nozawa H, Yamaguchi H, Watanabe T:

Anatomy of the middle rectal artery: a review of the historical literature. Surg

Today 47(1):14-19, 2017

183. Matsuzaki H, Ishihara S, Kawai K, Murono K, Otani K, Yasuda K, Nishikawa

T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Watanabe T: Smoking and

tumor obstruction are risk factors for anastomotic leakage after laparoscopic

anterior resection during rectal cancer treatment. Journal of the Anus, Rectum

and Colon 1(1):7-14, 2017

184. Matsuzaki H, Ishihara S, Kawai K, Murono K, Otani K, Yasuda K, Nishikawa

T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Yamaguchi H, Watanabe T:

Laparoscopic versus open surgery for obese patients with rectal cancer: a

retrospective cohort study. Surg Today 47(5):627-635, 2017

185. Murono K, Ishihara S, Kawai K, Kaneko M, Sasaki K, Otani K, Yasuda K,

Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Satoh Y, Kurihara

M, Yatomi Y, Watanabe T: Significance of carcinoembryonic antigen mRNA

in peritoneal lavage determined by transcription-reverse transcription

concerted method in patients with low rectal cancer. Asian J Surg 2017

186. Murono K, Ishihara S, Kawai K, Kaneko M, Sasaki K, Yasuda K, Otani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Hayashi A,

Ushiku T, Fukayama M, Watanabe T: Non-occlusive mesenteric ischemia

localized in the transverse colon: a case report. Surg Case Rep 3(1):23, 2017

187. Murono K, Ishihara S, Kawai K, Nagata H, Kaneko M, Sasaki K, Yasuda K,

Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H,

Watanabe T: Laparoscopic surgery for colorectal cancers complicated by

Leriche syndrome: A report of three cases. Oncol Lett 14(2):1920-1924, 2017

188. Murono K, Ishihara S, Watanabe T: Management of synchronous distant

metastasis of colorectal cancer. Nihon Shokakibyo Gakkai Zasshi

114(7):1209-1216, 2017

189. Nagai Y, Sunami E, Yamamoto Y, Hata K, Okada S, Murono K, Yasuda K,

Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H,

Ishihara S, Hoon DS, Watanabe T: LINE-1 hypomethylation status of

circulating cell-free DNA in plasma as a biomarker for colorectal cancer.

Oncotarget 8(7):11906-11916, 2017

190. Nagata H, Ishihara S, Hata K, Murono K, Kaneko M, Yasuda K, Otani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Watanabe T:

Survival and Prognostic Factors for Metachronous Peritoneal Metastasis in

Patients with Colon Cancer. Ann Surg Oncol 24(5):1269-1280, 2017

191. Nirei T, Ishihara S, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Nozawa H,

Watanabe T: Polymeric micelles loaded with

(1,2-diaminocyclohexane)platinum(II) against colorectal cancer. J Surg Res

218:334-340, 2017

192. Nozawa H, Ishihara S, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Nishikawa

T, Otani K, Yasuda K, Sasaki K, Murono K, Nakajima J, Watanabe T:

Characterization of Conversion Chemotherapy for Secondary Surgical

Resection in Colorectal Cancer Patients with Lung Metastases. Oncology

92(3):135-141, 2017


T, Otani K, Yasuda K, Sasaki K, Murono K, Watanabe T: A high

preoperative carbohydrate antigen 19-9 level is a risk factor for recurrence in

stage II colorectal cancer. Acta Oncol 56(5):634-638, 2017

194. Nozawa H, Ishihara S, Kawai K, Sasaki K, Murono K, Otani K, Nishikawa T,

Tanaka T, Kiyomatsu T, Hata K, Watanabe T: Brain Metastasis from

Colorectal Cancer: Predictors and Treatment Outcomes. Oncology

93(5):309-314, 2017

195. Ota Y, Yamada A, Kobayashi Y, Niikura R, Shimpoh T, Narita A, Yoshida S,

Suzuki N, Watabe H, Hirata Y, Ishihara S, Sunami E, Watanabe T, Koike K:

Diagnostic capability of colon capsule endoscopy for advanced colorectal

cancer: A pilot study. Dig Endosc 29(6):695-701, 2017

196. Otani K, Ishihara S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T,

Nishikawa T, Yasuda K, Sasaki K, Murono K, Watanabe T: A retrospective

study of laparoscopic surgery for small bowel obstruction. Ann Med Surg

(Lond) 16:34-39, 2017

197. Otani K, Ishihara S, Yamaguchi H, Murono K, Yasuda K, Nishikawa T,

Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Watanabe T:

Adiponectin and colorectal cancer. Surg Today 47(2):151-158, 2017

198. Sasaki K, Ishihara S, Hata K, Kiyomatsu T, Nozawa H, Kawai K, Tanaka T,

Nishikawa T, Otani K, Yasuda K, Kaneko M, Murono K, Abe H, Morikawa T,

Watanabe T: Radiation-associated colon cancer: A case report. Mol Clin

Oncol 6(6):817-820, 2017

199. Sasaki K, Ishihara S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T,

Nishikawa T, Otani K, Yasuda K, Murono K, Watanabe T: Successful

Management of a Positive Air Leak Test during Laparoscopic Colorectal

Surgery. Dig Surg 2017

200. Sato K, Tanaka T, Sato J, Shibata E, Nagai Y, Murono K, Yasuda K, Otani K,

Nishikawa T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Kazama

S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Ohtomo K, Watanabe T:

Usefulness of preoperative CT colonography for colon cancer. Asian J Surg

40(6):438-443, 2017

201. Shichijo S, Nomura S, Aoyama K, Nishikawa Y, Miura M, Shinagawa T,

Takiyama H, Tanimoto T, Ishihara S, Matsuo K, Tada T: Application of

Convolutional Neural Networks in the Diagnosis of Helicobacter pylori

Infection Based on Endoscopic Images. EBioMedicine 25:106-111, 2017

202. Shinagawa T, Ishihara S, Nozawa H, Murono K, Nishikawa T, Otani K,

Sasaki K, Yasuda K, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Yamaguchi

H, Hayashi A, Tanaka M, Ushiku T, Fukayama M, Watanabe T: Small

colorectal cancers resembling submucosal tumor with massive submucosal

invasion and lymph node metastasis: A report of two cases and review of the

literature. Clin Res Hepatol Gastroenterol 41(2):e19-e23, 2017

203. Shiratori H, Nishikawa T, Shintani Y, Murono K, Sasaki K, Yasuda K, Otani

K, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Ishihara S,

Fukayama M, Watanabe T: Perforation of jejunal diverticulum with ectopic

pancreas. Clin J Gastroenterol 10(2):137-141, 2017

204. Sonoda H, Kawai K, Yamaguchi H, Murono K, Kaneko M, Nishikawa T,

Otani K, Sasaki K, Yasuda K, Tanaka T, Kiyomatsu T, Hata K, Nozawa H,

Ishihara S, Aikou S, Yamashita H, Ushiku T, Seto Y, Fukayama M, Watanabe

T: Lymphogenous metastasis to the transverse colon that originated from

signet-ring cell gastric cancer: A case report and review of the literature. Clin

Res Hepatol Gastroenterol 41(6):e81-e86, 2017

205. Takiyama A, Tanaka T, Yamamoto Y, Hata K, Ishihara S, Nozawa H, Kawai

K, Kiyomatsu T, Nishikawa T, Otani K, Sasaki K, Watanabe T: Microsatellite

Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative

Colorectal Neoplasms. Anticancer Res 37(10):5785-5790, 2017

206. Takiyama H, Kawai K, Ishihara S, Yasuda K, Otani K, Nishikawa T, Tanaka

T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T: Different

Impacts of Preoperative Radiotherapy and Chemoradiotherapy on

Oncological Outcomes in Patients with Stages II and III Lower Rectal Cancer:

A Propensity Score Analysis. Dig Surg 2017

207. Tanaka T, Kobunai T, Yamamoto Y, Murono K, Otani K, Yasuda K,

Nishikawa T, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Ishihara S,

Watanabe T: Increased Copy Number Variation of mtDNA in an Array-based

Digital PCR Assay Predicts Ulcerative Colitis-associated Colorectal Cancer.

In Vivo 31(4):713-718, 2017

208. Watanabe T, Miyata H, Konno H, Kawai K, Ishihara S, Sunami E, Hirahara N,

Wakabayashi G, Gotoh M, Mori M: Prediction model for complications after

low anterior resection based on data from 33,411 Japanese patients included

in the National Clinical Database. Surgery 161(6):1597-1608, 2017

209. Yamashita H, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Okuma K, Abe

O, Watanabe T, Nakagawa K: Comparison of volumetric-modulated arc

therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in

25 fractions with conventional radiotherapy in preoperative chemoradiation

for rectal cancers: a propensity score case-matched analysis. Radiat Oncol

12(1):156, 2017

210. Yasuda K, Tanaka T, Ishihara S, Otani K, Nishikawa T, Kiyomatsu T, Kawai

K, Hata K, Nozawa H, Masui Y, Shintani Y, Watanabe T: Intestinal

perforation after nivolumab immunotherapy for a malignant melanoma: a case

report. Surg Case Rep 3(1):94, 2017

211. Arakawa K, Hata K, Nozawa H, Kawai K, Tanaka T, Nishikawa T, Sasaki K,

Shuno Y, Kaneko M, Hiyoshi M, Emoto S, Murono K, Sonoda H, Ishihara S:

Prognostic Significance and Clinicopathological Features of Synchronous

Colorectal Cancer. Anticancer Res 38(10):5889-5895, 2018

212. Harada Y, Kazama S, Morikawa T, Emoto S, Murono K, Kaneko M, Sasaki

K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Nozawa

H, Ishihara S, Watanabe T: Prognostic impact of doublecortin-like kinase 1

expression in locally advanced rectal cancer treated with preoperative

chemoradiotherapy. Apmis 126(6):486-493, 2018

213. Hirasawa T, Aoyama K, Tanimoto T, Ishihara S, Shichijo S, Ozawa T,

Ohnishi T, Fujishiro M, Matsuo K, Fujisaki J, Tada T: Application of

artificial intelligence using a convolutional neural network for detecting

gastric cancer in endoscopic images. Gastric Cancer 21(4):653-660, 2018

214. Hojo D, Murono K, Ishihara S, Kaneko M, Sasaki K, Yasuda K, Otani K,

Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H,

Watanabe T: Marked edema of colonic stoma after colectomy and severe

pulmonary hypertension: Report of two cases. Clin Res Hepatol Gastroenterol

42(1):e1-e4, 2018

215. Horie Y, Yoshio T, Aoyama K, Yoshimizu S, Horiuchi Y, Ishiyama A,

Hirasawa T, Tsuchida T, Ozawa T, Ishihara S, Kumagai Y, Fujishiro M,

Maetani I, Fujisaki J, Tada T: Diagnostic outcomes of esophageal cancer by

artificial intelligence using convolutional neural networks. Gastrointest

Endosc 2018

216. Ishida H, Yamaguchi T, Tanakaya K, Akagi K, Inoue Y, Kumamoto K,

Shimodaira H, Sekine S, Tanaka T, Chino A, Tomita N, Nakajima T,

Hasegawa T, Hinoi T, Hirasawa A, Miyakura Y, Murakami Y, Muro K,

Ajioka Y, Hashiguchi Y, Ito Y, Saito Y, Hamaguchi T, Ishiguro M, Ishihara S,

Kanemitsu Y, Kawano H, Kinugasa Y, Kokudo N, Murofushi K, Nakajima T,

Oka S, Sakai Y, Tsuji A, Uehara K, Ueno H, Yamazaki K, Yoshida M,

Yoshino T, Boku N, Fujimori T, Itabashi M, Koinuma N, T. M, Nishimura G,

Sakata Y, Shimada Y, Takahashi K, Tanaka S, Tsuruta O, Yamaguchi T,

Sugihara K, Watanabe T, Rectum JSfCotCa: Japanese Society for Cancer of

the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of

Hereditary Colorectal Cancer (Translated Version). Journal of the Anus,

Rectum and Colon 2(Supplement 1):S1-S51, 2018

217. Ishihara S, Kawai K, Tanaka T, Hata K, Nozawa H: Correlations between the

sizes of lateral pelvic lymph nodes and metastases in rectal cancer patients

treated with preoperative chemoradiotherapy. ANZ J Surg 88(12):1306-1310,

2018

218. Ishihara S, Kawai K, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Morikawa

T, Watanabe T: Diagnostic value of FDG-PET/CT for lateral pelvic lymph

node metastasis in rectal cancer treated with preoperative chemoradiotherapy.

Tech Coloproctol 22(5):347-354, 2018

219. Ishihara S, Kiyomatsu T, Kawai K, Tanaka T, Hata K, Kazama S, Sunami E,

Nozawa H, Watanabe T: The short-term outcomes of robotic

sphincter-preserving surgery for rectal cancer: comparison with open and

laparoscopic surgery using a propensity score analysis. International Journal

of Colorectal Disease 33(8):1047-1055, 2018

220. Ishihara S, Murono K, Sasaki K, Yasuda K, Otani K, Nishikawa T, Tanaka T,

Kiyomatsu T, Kawai K, Hata K, Nozawa H, Sugihara K, Watanabe T: Impact

of Primary Tumor Location on Postoperative Recurrence and Subsequent

Prognosis in Nonmetastatic Colon Cancers: A Multicenter Retrospective

Study Using a Propensity Score Analysis. Ann Surg 267(5):917-921, 2018

221. Kishikawa J, Hata K, Kazama S, Anzai H, Shinagawa T, Murono K, Kaneko

M, Sasaki K, Yasuda K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T,

Kawai K, Nozawa H, Ishihara S, Morikawa T, Fukayama M, Watanabe T:

Results of a 36-year surveillance program for ulcerative colitis-associated

neoplasia in the Japanese population. Dig Endosc 30(2):236-244, 2018

222. Murono K, Nagata H, Ishimaru K, Emoto S, Kaneko M, Hiyoshi M, Sasaki K,

Otani K, Shuno Y, Nishikawa T, Tanaka T, Hata K, Kawai K, Nozawa H,

Muro K, Ishihara S: Safety of intraperitoneal paclitaxel combined with

conventional chemotherapy for colorectal cancer with peritoneal

carcinomatosis: a phase I trial. Cancer Chemother Pharmacol 2018

223. Nagata H, Ishihara S, Kishikawa J, Sonoda H, Murono K, Emoto S, Kaneko

M, Sasaki K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai

K, Nozawa H: CD133 expression predicts post-operative recurrence in

patients with colon cancer with peritoneal metastasis. Int J Oncol

52(3):721-732, 2018

224. Nagata H, Ishihara S, Oba K, Tanaka T, Hata K, Kawai K, Nozawa H:

Development and Validation of a Prediction Model for Postoperative

Peritoneal Metastasis After Curative Resection of Colon Cancer. Ann Surg

Oncol 25(5):1366-1373, 2018

225. Nishikawa T, Ishihara S, Emoto S, Kaneko M, Murono K, Sasaki K, Otani K,

Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Watanabe T:

Multivisceral resections for locally advanced colorectal cancer after

preoperative treatment. Mol Clin Oncol 8(3):493-498, 2018


T, Otani K, Yasuda K, Sasaki K, Kaneko M, Murono K: Conversion to

Resection in Patients Receiving Systemic Chemotherapy for Unresectable

and/or Metastatic Colorectal Cancer-Predictive Factors and Prognosis. Clin

Colorectal Cancer 17(1):e91-e97, 2018

227. Okuno T, Kawai K, Koyama K, Takahashi M, Ishihara S, Momose T,

Morikawa T, Fukayama M, Watanabe T: Value of FDG-PET/CT Volumetry

After Chemoradiotherapy in Rectal Cancer. Dis Colon Rectum 61(3):320-327,

2018

228. Sasaki K, Ishihara S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T,

Nishikawa T, Otani K, Yasuda K, Murono K, Watanabe T: Successful

Management of a Positive Air Leak Test during Laparoscopic Colorectal

Surgery. Dig Surg 35(3):266-270, 2018

229. Shinagawa T, Hata K, Morikawa T, Takiyama H, Otani K, Nishikawa T,

Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Ishihara S, Nakamura H,

Fukayama M, Watanabe T: Protrusion on the Depressed Surface of

Non-polypoid T1 Colorectal Cancer Is Associated with Venous Invasion.

Anticancer Res 38(2):993-1002, 2018

230. Takiyama H, Kawai K, Ishihara S, Yasuda K, Otani K, Nishikawa T, Tanaka

T, Kiyomatsu T, Hata K, Nozawa H, Morikawa T, Watanabe T: Different

Impacts of Preoperative Radiotherapy and Chemoradiotherapy on

Oncological Outcomes in Patients with Stages II and III Lower Rectal Cancer:

A Propensity Score Analysis. Dig Surg 35(3):212-219, 2018

231. Takiyama H, Ozawa T, Ishihara S, Fujishiro M, Shichijo S, Nomura S, Miura

M, Tada T: Automatic anatomical classification of

esophagogastroduodenoscopy images using deep convolutional neural

networks. Scientific Reports 82018

232. Watanabe T, Ishihara S. Management of Lateral Pelvic Lymph Nodes. In:

Chang GJ, editor. Rectal Cancer: Modern Approaches to Treatment. 1 ed.

Switzerland: Springer International Publishing; 2018. p. 213-230.

233. Watanabe T, Ishihara S, Moriya Y. Q & As on Surgery: Is lateral nodal

dissection cost effective in surgical management of rectal cancer? In:

Valentini V, Schmoll HJ, van de Velde CJ, editors. Multidisciplinary

Management of Rectal Cancer: Questions and Answers. 2nd ed. Switzerland:

Springer International Publishing; 2018.

234. Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y, Hamaguchi T,

Ishida H, Ishiguro M, Ishihara S, Kanemitsu Y, Kawano H, Kinugasa Y,

Kokudo N, Murofushi K, Nakajima T, Oka S, Sakai Y, Tsuji A, Uehara K,

Ueno H, Yamazaki K, Yoshida M, Yoshino T, Boku N, Fujimori T, Itabashi

M, Koinuma N, Morita T, Nishimura G, Sakata Y, Shimada Y, Takahashi K,

Tanaka S, Tsuruta O, Yamaguchi T, Yamaguchi N, Tanaka T, Kotake K,

Sugihara K, Japanese Society for Cancer of the C, Rectum: Japanese Society

for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the

treatment of colorectal cancer. Int J Clin Oncol 23(1):1-34, 2018

235. Aoki T, Yamada A, Aoyama K, Saito H, Tsuboi A, Nakada A, Niikura R,

Fujishiro M, Oka S, Ishihara S, Matsuda T, Tanaka S, Koike K, Tada T:

Automatic detection of erosions and ulcerations in wireless capsule

endoscopy images based on a deep convolutional neural network. Gastrointest

Endosc 89(2):357-363.e352, 2019

236. Arakawa K, Hata K, Nozawa H, Kawai K, Tanaka T, Nishikawa T, Sasaki K,

Shuno Y, Kaneko M, Hiyoshi M, Emoto S, Murono K, Sonoda H, Okada S,

Ishihara S: Molecular Subtypes Are Frequently Discordant Between Lesions

in Patients With Synchronous Colorectal Cancer: Molecular Analysis of 59

Patients. Anticancer Res 39(3):1425-1432, 2019

237. Emoto S, Nozawa H, Kawai K, Hata K, Tanaka T, Shuno Y, Nishikawa T,

Sasaki K, Kaneko M, Hiyoshi M, Murono K, Ishihara S: Venous

thromboembolism in colorectal surgery: Incidence, risk factors, and

prophylaxis. Asian J Surg 2019

238. Hata K, Anzai H, Ikeuchi H, Futami K, Fukushima K, Sugita A, Uchino M,

Higashi D, Itabashi M, Watanabe K, Koganei K, Araki T, Kimura H,

Mizushima T, Ueda T, Ishihara S, Suzuki Y: Surveillance Colonoscopy for

Ulcerative Colitis-Associated Colorectal Cancer Offers Better Overall

Survival in Real-World Surgically Resected Cases. Am J Gastroenterol

114(3):483-489, 2019

239. Hata K, Watanabe H, Ishihara S, Toyoshima O: Gauze-like appearance of the

sigmoid colon. Lancet Gastroenterol Hepatol 4(5):412, 2019

240. Horie Y, Yoshio T, Aoyama K, Yoshimizu S, Horiuchi Y, Ishiyama A,

Hirasawa T, Tsuchida T, Ozawa T, Ishihara S, Kumagai Y, Fujishiro M,

Maetani I, Fujisaki J, Tada T: Diagnostic outcomes of esophageal cancer by

artificial intelligence using convolutional neural networks. Gastrointest

Endosc 89(1):25-32, 2019

241. Kitamura C, Sonoda H, Nozawa H, Kano K, Emoto S, Murono K, Kaneko M,

Hiyoshi M, Sasaki K, Nishikawa T, Shuno Y, Tanaka T, Hata K, Kawai K,

Aoki J, Ishihara S: The component changes of lysophospholipid mediators in

colorectal cancer. Tumour Biol 41(5):1010428319848616, 2019

242. Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T,

Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H,

Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T,

Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y,

Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama

M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H:

Comprehensive assay for the molecular profiling of cancer by target

enrichment from formalin-fixed paraffin-embedded specimens. Cancer Sci

110(4):1464-1479, 2019

243. Kondo K, Matsusaka S, Ishihara S, Horie H, Uehara K, Oguchi M, Murafushi

K, Ueno M, Mizunuma N, Shimbo T, Kato D, Okuda J, Hashiguchi Y,

Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y, Fujii

M, Nakajima T: Long-term results of a multicenter phase II study of

preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally

advanced rectal cancer (JACCRO CC-04: SHOGUN Trial). Radiother Oncol

134:199-203, 2019

244. Kumagai Y, Takubo K, Kawada K, Aoyama K, Endo Y, Ozawa T, Hirasawa

T, Yoshio T, Ishihara S, Fujishiro M, Tamaru JI, Mochiki E, Ishida H, Tada

T: Diagnosis using deep-learning artificial intelligence based on the

endocytoscopic observation of the esophagus. Esophagus 16(2):180-187,

2019

245. Miyake H, Murono K, Nagata H, Nozawa H, Kawai K, Hata K, Tanaka T,

Nishikawa T, Shuno Y, Sasaki K, Ishihara S: Prognostic significance of

doubling time in patients undergoing radical surgery for metachronous

peritoneal metastases of colorectal cancer. Int J Colorectal Dis 34(5):801-809,

2019

246. Murono K, Nagata H, Ishimaru K, Emoto S, Kaneko M, Hiyoshi M, Sasaki K,

Otani K, Shuno Y, Nishikawa T, Tanaka T, Hata K, Kawai K, Nozawa H,

Muro K, Ishihara S: Safety of intraperitoneal paclitaxel combined with

conventional chemotherapy for colorectal cancer with peritoneal

carcinomatosis: a phase I trial. Cancer Chemother Pharmacol 83(1):145-150,

2019

247. Nagata H, Ishihara S, Abe H, Ushiku T, Kishikawa J, Tanaka T, Hata K,

Kawai K, Fukayama M, Nozawa H: LGR5 expression predicts peritoneal

recurrence after curative resection of primary colon cancer. Br J Cancer

120(10):996-1002, 2019

248. Nozawa H, Morikawa T, Kawai K, Hata K, Tanaka T, Nishikawa T, Sasaki K,

Shuno Y, Kaneko M, Hiyoshi M, Emoto S, Murono K, Sonoda H, Fukayama

M, Ishihara S: Obstruction is associated with perineural invasion in T3/T4

colon cancer. Colorectal Dis 2019

249. Nozawa H, Shinagawa T, Kawai K, Hata K, Tanaka T, Nishikawa T, Sasaki

K, Kaneko M, Murono K, Emoto S, Sonoda H, Ishihara S: Laparoscopic

surgery in rectal cancer patients taking anti-thrombotic therapy. Minim

Invasive Ther Allied Technol:1-8, 2019

250. Ozawa T, Ishihara S, Fujishiro M, Saito H, Kumagai Y, Shichijo S, Aoyama

K, Tada T: Novel computer-assisted diagnosis system for endoscopic disease

activity in patients with ulcerative colitis. Gastrointest Endosc

89(2):416-421.e411, 2019

251. Shichijo S, Endo Y, Aoyama K, Takeuchi Y, Ozawa T, Takiyama H, Matsuo

K, Fujishiro M, Ishihara S, Ishihara R, Tada T: Application of convolutional

neural networks for evaluating Helicobacter pylori infection status on the

basis of endoscopic images. Scand J Gastroenterol 54(2):158-163, 2019

252. Shinagawa T, Hata K, Morikawa T, Matsunaga K, Emoto S, Murono K,

Kaneko M, Sasaki K, Nishikawa T, Tanaka T, Kawai K, Nozawa H,

Fukayama M, Ishihara S: Loss of RUNX3 Immunoreactivity in

Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative

Colitis-Associated Colorectal Cancer. Digestion:1-9, 2019

CURRICULUM VITAE Soichiro Ishihara, M.D., Ph. D. · CURRICULUM VITAE Soichiro Ishihara, M.D., Ph....

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