Clustering Validity Adriano Joaquim de O Cruz ©2006 NCE/UFRJ [email protected].
CURRICULUM VITAE Prof. Adriano Mollica
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1 CURRICULUM VITAE Prof. Adriano Mollica Nome: Adriano Mollica Academic position: Full Professor in Medicinal Chemistry at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara. Personal details: Prof. Adriano Mollica, PhD, FRSC Date and Place of Birth 23/08/1977 Genzano di Roma (RM), Italia Home Address Strada degli Oliveti 73 66100 (CH) Phone +393314675187 Office: Department of Pharmacy University of Chieti-Pescara “G. D’ Annunzio” Via dei Vestini 31 66100 Chieti Scalo (Chieti), ITALIA Phone +3908713554476 Email: [email protected] Scientific Parameters N° Papers: 201 N° citations: 3235 H index: 31 (from scopus) Department Duties Board of the Department of Pharmacy from 2017-18 till today. Coordinator of the “Chemistry Section” of the Departiment fo Pharmacy 2017-2019 Member of the National Commission for confirmation in role of university researchers from 1/1/2018 to 31/12/2019 sector: medicinal chemistry. Member of the Council of the University Museum of the University "G. d'Annunzio" of Chieti - Pescara from 12/7/2018 till today Supplent Member of the Discipline Board of the University “G.d’Annunzio”, from 2019 till today . PhD Coordinator of PhD programm: “Pharmaceutical and Biomolecular Sciences” of the University “G.d’Annunzio 2020-today Summary of the research activity of Prof Adriano Mollica: - Synthesis of peptides and pseudopeptides active on FPCRs, such as opioid receptors, FPR receptors, cannabinoids, T1R2. - Antimicrobic peptide, anti-neurodegenerative, appetite and food intake control, enzymatic inhibition. - Design of Building blocks for peptide chemistry. - Nutraceutical development from edible Mediterranean plants, for dysmetabolism, such as diabetes and hyperlipidemia. - ADME-Tox, Molecular modeling and Dynamic. Book Chapters (from Scopus) 1) Locatelli, M., Cifelli, R., Vitalei, S., Santini, P., de Luca, E., Bellagamba, G., Celia, C., Carradori, S., Marzio, L.D., Mollica, A.
Transcript of CURRICULUM VITAE Prof. Adriano Mollica
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CURRICULUM VITAE
Prof. Adriano Mollica
Nome: Adriano Mollica
Academic position: Full Professor in Medicinal Chemistry at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara.
Personal details: Prof. Adriano Mollica, PhD, FRSC
Date and Place of Birth
23/08/1977 Genzano di Roma (RM), Italia
Home Address Strada degli Oliveti 73
66100 (CH)
Phone +393314675187 Office:
Department of Pharmacy
University of Chieti-Pescara “G. D’ Annunzio” Via dei Vestini 31
66100 Chieti Scalo (Chieti), ITALIA
Phone +3908713554476 Email: [email protected]
Scientific Parameters
N° Papers: 201
N° citations: 3235
H index: 31
(from scopus)
Department Duties
Board of the Department of Pharmacy from 2017-18 till today.
Coordinator of the “Chemistry Section” of the Departiment fo Pharmacy 2017-2019
Member of the National Commission for confirmation in role of university researchers from 1/1/2018 to 31/12/2019 sector: medicinal chemistry.
Member of the Council of the University Museum of the University "G. d'Annunzio" of Chieti - Pescara from 12/7/2018 till today
Supplent Member of the Discipline Board of the University “G.d’Annunzio”, from 2019 till today .
PhD Coordinator of PhD programm: “Pharmaceutical and Biomolecular Sciences” of the University “G.d’Annunzio 2020-today
Summary of the research activity of Prof Adriano Mollica:
- Synthesis of peptides and pseudopeptides active on FPCRs, such as opioid receptors, FPR receptors, cannabinoids, T1R2.
- Antimicrobic peptide, anti-neurodegenerative, appetite and food intake control, enzymatic inhibition.
- Design of Building blocks for peptide chemistry.
- Nutraceutical development from edible Mediterranean plants, for dysmetabolism, such as diabetes and hyperlipidemia.
- ADME-Tox, Molecular modeling and Dynamic.
Book Chapters (from Scopus)
1) Locatelli, M., Cifelli, R., Vitalei, S., Santini, P., de Luca, E., Bellagamba, G.,
Celia, C., Carradori, S., Marzio, L.D., Mollica, A.
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Method validation and hyphenated techniques: Recent trends and future perspectives
(2017) Analytical Chemistry: Developments, Applications and Challenges in Food
Analysis, pp. 1-22.
ISBN: 9781536122824; 9781536122671
DOCUMENT TYPE: Book Chapter
2) Mollica, A., Stefanucci, A., Costante, R., Hruby, V.J.
Rational approach to the design of bioactive peptidomimetics: Recent developments
in opioid agonist peptides (2015) Studies in Natural Products Chemistry, 46, pp.
27-68. Cited 5 times.
DOI: 10.1016/B978-0-444-63462-7.00002-6
ISSN: 15725995
DOCUMENT TYPE: Article
NOTA: questo prodotto è riportato erroneamente da scopus come articolo in rivista,
ma è un capitolo di libro, pertanto è riportato in questa sezione, e non
considerato ai fini del calcolo degli indici.
Books for Students
1) Locatelli, M.; Mollica, A. Fondamenti Di Chimica Analitica e Analisi dei Medicinali, Aracne Editrice 2013, ISBN 978-88-548-6106-0.
2) Mollica, A. Lezioni di chimica farmaceutica, Aracne Eds. 2015 ISBN 978-88-548-8252-2
3) Mollica, A. Lezioni di chimica farmaceutica, Aracne Eds” II edizione, è inserito nella collana “Synthesis, Il farmaco e la sua chimica” curata by Prof. Antonio Carta. (accettato in data 19/1/2018) in press.
Papers for Magazines:
1) Adriano Mollica, Roberto Costante, Giorgia Macedonio, Simone Carradori, Azzurra Stefanucci, Nuove prospettive nella progettazione di farmaci analgesici multi-target, in Scienze e Ricerche n. 7, maggio 2015, pp. 85-90
2) Giorgia Macedonio, Fabio Frallonardo, Azzurra Stefanucci, Simone Carradori, Adriano Mollica, Farmaci che agiscono sul
sistema cannabinoide, lo stato dell’arte e prospettive future, in Scienze e Ricerche n. 34, 1° Aug. 2016, pp. 67-73. 3) General articles on traditional medicine: ”Salute, alimentazione e tradizione” for the news paper “Con i Piedi Per Terra”,
eds.SpeakOut. From 2016 till today.
Editorials 1) Mollica, A.
Preface
(2018) Current Bioactive Compounds, 14 (1), p. 2.
DOI: 10.2174/157340721401180430152457
ISSN: 15734072
DOCUMENT TYPE: Editorial
2) Mollica, A.
Meet our editor
(2017) Current Bioactive Compounds, 13 (1), p. 1.
ISSN: 15734072
DOCUMENT TYPE: Editorial
3) Mollica, A.
Editorial
(2017) Current Bioactive Compounds, 13 (1), p. 2.
ISSN: 15734072
DOCUMENT TYPE: Editorial
4) Mollica, A.
Meet our editor
(2016) Current Bioactive Compounds, 12 (1), p. 1.
DOI: 10.2174/157340721201160404093341
ISSN: 15734072
DOCUMENT TYPE: Editorial
5) Mollica, A.
Editorial
(2016) Current Bioactive Compounds, 12 (1), p. 2.
DOI: 10.2174/157340721201160404093525
ISSN: 15734072
DOCUMENT TYPE: Editorial
6) Mollica, A.
3
Meet our editor
(2015) Current Bioactive Compounds, 11 (1), p. 1.
ISSN: 15734072
DOCUMENT TYPE: Editorial
7) Mollica, A.
New challenges and opportunities for Current Bioactive Compounds (CBC)
(2013) Current Bioactive Compounds, 9 (3), p. 183.
ISSN: 15734072
DOCUMENT TYPE: Editorial
Academic Titles
- Master Degree in Pharmacy, University of Rome “La Sapienza” 18/7/2001, (107/110). - Master Degree in Chemistry and Pharmaceutical Technology, University of Rome, “La Sapienza” a.a. 13/3/2008 (105/110).
- Volunteer scientist: a.a. 1/9/2001-31/10/2002 at the National Research Centre for the stusy of the Drug Chemistry, “Centro per lo Studio per la Chimica del Farmaco” at the Department of Pharmaceutical Studies, University of Rome, “La Sapienza”.
- PhD “Pharmaceutical Sciences” University of Rome, “La Sapienza” PhD Defense 7/4/2006. Tutor: Prof. Mario Paglialunga
Paradisi. - Volunteer Scientist: CNR centro di “Chimica Biomolecolare” presso il Dipartimento di “Scienze del Farmaco” University of Rome,
“La Sapienza” a.a. 1/09/2005-30/4/2006.
- Post Doc, at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara. 2006-2008. Tutor: Prof. Francesco Pinnen.
Post Doc, at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara. 2007-2008. Tutor: Prof.
Francesco Pinnen.
- Post Doc, at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara.2008-2009. Tutor: Prof.
Francesco Pinnen.
-Assistent Professor in Medicinal Chemistry, Department of Pharmacy, at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara. 2008-2016.
-Associate Professor in Medicinal Chemistry, Department of Pharmacy, at the Department of Pharmacy, University of the Studi “G.
d’Annunzio” of Chieti-Pescara. 2016-oggi
-Full Professor in Medicinal Chemistry, at the Department of Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara.”
from 15/01/2019
Talks at international Congress
Seminars
"Invited Speaker" presso The University of California, Irvine (UCI), Seminar Programme. Title: "Design, synthesis, and biological data of endomorphin 1 and 2 analogues" from 06-10-2009 to 06-10-2009
"Invited Lecturer" for the Seminar programme, organizzatobyProf. Frank Porreca of the University of Arizona, department of Pharmacology. Title presentazione: “Synthesis and activity of endomorphin-2 and morphiceptin analogues
with proline surrogates in position 2" dal 13-10-2009 to 13-10-2009
Lesson for the "Master di II livello in Sostanze Organiche Naturali" , Dipartimento di Chimica, University “Sapienza” di Roma. Direttore of master, Prof. A. Bianco a.a. 2013-14. Title della lezione: "Approccio razionale alla progettazione di
peptidomimetici bioattivi: Peptidi oppioidi"from14-02-2014 to 14-02-2014
"Invited Lecturer" for the seminar programme presso The Biochemistry Department of The Biological Research Centre of The Hungarian Academy of Science, invitatofromProf. Benyhe Sandor. Title della presentazione: "Design and synthesis
of super potent analgesic peptides: Biphalin analogues, a Successful Story".from20-12-2014 to 20-12-2014
Congress
Speaker at to convegno scientifico internazionale at The XII National Symposium with international Partecipation
"Medicinal Plants - Present and Perspectives". Title della comunicazione orale: "In Vivo and in vitro evaluation of the anti-diabetic nutracetuical potentials of Capparis spinosa".from06-09-2016 to 09-09-2016.
Speaker at convegno scientifico nazionale SCI. Tipo di Contributo: "Invited, Plenary Lecture": XXXV TUMA 2016 (congresso delle sezioni Toscana-Umbria-Marche-Abruzzo della Società Chimica Italiana). title: Progettazione di Peptidi
ciclici agonisti misti mu/delta oppioidi"from25-09-2016 to 27-09-2016.
Invited Speaker, al convegno scientifico internazionale: 4th International BAU DRUG DESIGN CONGRESS. Title della presentazione orale: "Design, Synthesis and biological evaluation of novel cyclic analogues of biphalin and DPDPE with
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xylene bridges as mixed mu/delta opioid agonist"from13-10-2016 to 15-10-2016, Istanbul
Invited Speaker al 5th International BAU DRUG DESIGN CONGRESS, october 19-21, 2017, Istanbul. Title della
presentazione orale: “ Design of the beta-sheet ARC repressor mimetics: conformational analysis and binding properties of linear and cyclic peptides”.
Invited Speaker al II Gazi Pharma Symposium, 11-13 ottobre 2017, Ankara, Title della presentazione: “CLIPS (Chemical linkage of Peptides onto Scaffolds) Technology applied to Opioid Peptides Research)”.
Speaker at al 12th International Symposium on Pharmaceutical Sciences, Giugno 26-29, 2018, Ankara. Title della comunicazione orale: “CLIPS (Chemical linkage of Peptides onto Scaffolds) Technology applied to Opioid Peptides
Research)”
Invited Speaker al IX international Congress on Hazelnut, 15-19 Agosto, Samsun, Turchia. PresentazioneTitolo:
“Assessment of the nutraceutical potential of Corylus Avellana L. fruit (hazelnut) from different geographic origin, antioxidant properties, fatty acid composition and enzyme inhibition”
Speaker at al workshop “Canapa Fashination” at the Department of Pharmacy, University of the Study “G. d’Annunzio” of Chieti-Pescara. 18 maggio 2017. title: “sintesi ed attività biologica di nuovi ligandi bivalenti oppioidi/ cannabinoidi”.
Speaker at to 16th Naples Workshop, Title presentazione orale CLIPS (Chemical linkage of Peptides onto Scaffolds) Technology applied to Opioid Peptides Research)”, Napoli 7-9-giugno-2018
Speaker at Workshop “Nutraceutici e Alimenti Funzionali” , at the Department of Pharmacy, University of the Study “G. d’Annunzio” of Chieti-Pescara. 9 march 2018, title: “Nutraceutica e Diabete”.
Organizing Commettee of Workshop: “Filiere integrate e ricerca scientifica” 20 DEC 2017, at the Department of
Pharmacy, University of the Studi “G. d’Annunzio” of Chieti-Pescara.
Chairman: "Site directed mutagenesis, molecular docking and dynamics simulations on asparaginase to treat leukemia" of Prof. Sako Mirzaie, Department of Biochemistry, Islamic Azad University, Sanandaj, Iran, at the Department of Pharmacy,
University of the Study “G. d’Annunzio” of Chieti-Pescara..
dal 04-07-2016 to 04-07-2016.
Chairman at the 5th International BAU DRUG DESIGN CONGRESS, 19-21/10, 2017.
Speakers at the XXVI National Meeting on Medicinal chemistry 2019, Milano. Presentation title: Targeting the opioid receptors: Biphalin analogues design. 16-19th July 2019.
Chairman at the RPDA 2019, Pescara 8-12 sept 2019.
International Collaborations
"Visiting Scientist" con "Research fellowship" presso il Gruppo di Ricerca of Prof. Victor J. Hruby, Dipartimento di Chimica dell' University dell' Arizona, Tucson, USA (12 mesi) Supportatabyfinanziamento numero DA 06284 (US Public
Health Service, National Institute of Drug Abuse). Sono stati Prodotti 12 articoli derivati dalla nostra collaborazione, tutt’ora in corso, indicizzati scopusfrom15-01-2004 to
oggi
Group Leader, research goup of Chimica Farmaceutica of Dipartimento di Farmacia, University "G. d'Annunzio" di Chieti-Pescara. (3 anni di assegno di collaborazione per attività di ricerca (2006-2008), ricercatore universitario confermato (2008-2016), professore seconda fascia (2016-oggi). Prodotte 31 pubblicazioni col Prof. Francesco Pinnen, indicizzate
scopus, oltre 60 lavori con la Dr. Azzurra Stefanucci, 22 lavori Dr. Roberto costante, 6 lavori con la Dr.ssa Grazia Luisi. I
lavori pubblicati sono caratterizzati da collaborazioni a livello nazionale e internazionale. La partecipazione al gruppo è attivafrom01-05-2006 tilloggi, anche in qualità di responsabilefrom2016.
Partecipation of the Research activities of Dr. Stefano Pieretti, Italian Health Institute: "Il dolore cronico: studio di nuove entità chimiche a presunta attività analgesica ed antiinfiammatoria" autorizzato in data 2/2/2012 n° 4844; e "La valutazione
pre-clinica di nuove molecole ad attività analgesico-infiammatoria: studio di nuovi modelli e paradigmi sperimentali che
consentano una maggiore predittività riducendo i tempi di sviluppo", 2/2/2012 n° 4824. from 02-02-2012 till today.
“Visiting Scientist” Scholar aa. 2004-2005 (1 year) Faculty of Chemistry at the University of Arizona (Az,
Tucson, US),
“Visiting Scientist” in 2014-15 two months at the Biological Research Institute of the Hungarian Academy of
Science (Szeged, Hungary)
“Visiting Scientist”, in 2015 one month at the Biophysics Department of The BAU University (Istanbul,
Turkey), “Visiting Scientist” in 2016 he was two months “Visiting Scientist” at the Dep. of Pharmacy, Univ.
of Pisa (Italy),
“Visiting Scientist” in 2017 one month at the Science Faculty of Selcuk, Dept. of Biochemistry, University of
Konya (turkey).
Partecipation of the Research activities of del
Prof. Sako Mirzaie, Department of Biochemsitry, Science Faculty, Islamic Azad University, Sanandaj Branch Pasdaran Ave., Sanandaj, Kurdistan, Iran. prodotte 5 pubblicazioni indicizzate su scopus from01-01-2015 till today
Scientific responsibility of the "Host Organisation", Dipartimento di Farmacia, University "G d' Annunzio" di Chieti-Pescara, per il Programma Internazionale di PhD students exchange: "Campus Hungary Placement" N° B2/1SZ/18008
In collaborazione con: University of Szeged, Faculty of Medicine, Szeged, Hungary. Prodotte 7 pubblicazioni col Dr
Dvoracsko Szalbolcs, Hungarian Academy of Science, BRC, Szeged, indicizzate su scopus. European patent pending: European Patent Application No. 18170728.2 filing date 04/05/2018, Title: Indazole derivatives as modulators of the
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cannabinoid system. (Brevetto N.3 di questo CV)
Scientific responsibility of the "Cooperation Agreement" tra il Prof. Sàndor Benyhe Biological Research Centre of the Hungarian Academy of Sciences il Dipartimento di Farmacia, University di Chieti-Pescara "G. D' Annunzio" supported by
grant n° Tàmop-4.1.1.1.C-13/1/KONV-20'14-0001.
Visiting Scientist at the research group of Prof. Serdar Durdagi, Bahcesehir University, School of Medicine, Department of Biophysics, Istanbul, Turkey. (1 mese) from19-07-2015 to 21-08-2015.
Collaboration international witn the “Neuroendocrine Research Unit”, Department of Pharmacology and Therapeutics,
Ladoke Akintola University of Technology, Osogbo, Nigeria.
Interantional Collaboration with il Prof. Chin-Kun Wang president della International society for Nutraceuticals and
Functional Foods e Chung Shan Medical University, Taiwan, (China) from01-01-2016 tilltoday.
Visiting Scientist at the research group of Prof. Tiziano Tuccinardi, Dipartimento di Farmacia, University di Pisa from11-01-2016 to 26-02-2016.
"Guest Professor" at the Selcuk University, Science Faculty, Department of Biology, Research group of Prof. Gokhan Zengin. (Periodo durata 6 giorni) from17-10-2016 to 22-10-2016,
Campus/Konya, TURKEY (erogate 6 ore lezione frontale).
“Visiting Scientist” at the Selcuk University, Science Faculty, Department of Biology, Research group of Prof. Gokhan Zengin. from31/7/2017 to 1/9/2017 (1 mese). Prodotte oltre 45
pubblicazioni in collaborazione col Gruppo di Ricerca of Prof Gokhan, indicizzate su scopus.
Scientific Collaboration with Prof. John Streicher, University of Arizona.
Referee for national and international grants:
Referee Area Gev3 VQR 2004-2010 dal 01-01-2012 to 31-12-2014
Referee Area Gev5 VQR 2004-2010 dal 01-01-2012 to 31-12-2014
International Referee for National Grant applications in Life Sciences for the National Science Centre of Poland dal 01-01-2014 tilltoday.
Scientific advisor of Bio-Targeting LtD dal 01-01-2014 tilltoday
Referee for VQR 2011-2014 GEV03 dal 01-01-2016 tilltoday
Referee for National Science Centre of Poland Progetti "Sonata" e "Preludium" dal 15-06-2016 tilltoday
Referee for Reprise, section: Ricerca industriale competitiva e per lo sviluppo sociale, from1/1/2016 till today
Funding and research Aggreements
PI: "Responsabile Scientifico e Coordinatore delle attività di Ricerca" , Accordo di Collaborazione scientifica tra l' ateneo "G'. d'Annunzio" e L' istituto Superiore di Sanità di Roma from25-03-
2014 tilltoday.
PI:del "Cooperation Agreement" between Dr. Sàndor Benyhe Biological Research Centre of the Hungarian Academy of
Sciences and Dr. Adriano Mollica, Dipartimento di Farmacia, University di Chieti-Pescara "G. D' Annunzio" supported by the grant n° Tàmop-4.1.1.1.C-13/1/KONV-20'14-0001
dal 26-06-2015 till today.
PI della rubrica "Alimentazione, Salute e Tradizione" per la rivista "Con i piedi per terra" eds. Speak Out srl dal 01-11-2015 till today.
Scientific Councelor: "Consulente Scientifico Esterno" presso l’Azienda Agroalimentare CaperSud. Responsabile incaricato dello studio scientifico di "Proprietà nutraceutiche dei prodotti agroalimentari derivati da Capparis Spinosa", Analisi e relazione tecnica per la richiesta of marchio DOP. from01-09-2016 ad today.
PhD Tutor for the PhD “Scienze of Farmaco” XXVII Cycle of Dr. Roberto Costante, Ciclo XXVII. Thesys defence at 10/4/2015. title: "Synthesis and evaluation of
analgesic, chemotactic and anticancer peptides" from 01-01-2012 to 10-04-2015
PhD Tutor of Tesi di Dottorato in Scienze Biomolecolari e Farmaceutiche, della Dr.ssa Giorgia Macedonio Ciclo XXX, (in corso) dal 01-11-2014 to 5-5-2018
PhD Tutor of Biomolecular and pharmaceutic sciences for Dr. Marilisa Pia Dimmito, Cycle XXX, (till today) dal 01-11-2016 till today. (Dottorato ancora in corso).
PhD Tutor of Biomolecular and pharmaceutic sciences for Dr.Alice Della Valle Dimmito, Ciclo XXXII, (in corso) dal 01-11-2019 till today. (Dottorato ancora in corso).
International Tutor of the fellow to Sengul Uysal, con borsa erogata dallo “Scientific and Technological Research Council of Turkey” (TUBITAK), till today.
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Local Unit Coordinator: ITALIAN MINISTERY of UNIVERSITY and RESEARCH program, founded project
PRIN2017 titled: Making Way For Small Molecules: Novel Chemotherapeutic Agents Acting at Tumor-Immune Interface.
Project expiration 2022.
Local Unit Coordinator: University of Mautitius, grant: MRCI/SCP-A037 : In silico identification of new antiviral pharmacophores from the floral biodiversity and approved phytochemicals in the fight against COVID-19" acronimo:
Phyto-COVID-19
Department Funding
Principal Investigator: Fondi di Ateneo per la Ricerca Scientifica. Approvati 4800,00 euro. Title of progetto: Progettazione
e sintesi di derivati analoghi di endomorphine e bifaline ad attività analgesica" a.a. 2012-13.
Principal Investigator: Fondi di Ateneo per la Ricerca Scientifica. Approvati: 4740,00 euro. Title of Progetto: Progettazione e sintesi di derivati analoghi di endomorphine sustituite in
posizione 2" a.a. 2013-14.
Principal Investigator: Fondi Di Ateneo per la Ricerca Scientifica.
Approvati:5060,64 Euro. Title of Progetto: "Sintesi di analgesici multi-target"
a.a. 2014-15.
Principal Investigator: Fondi Di Ateneo per la Ricerca Scientifica Fondi Approvati: 5980,91 Euro Title Progetto:"Design and synthesis of new bivalent molecules based on opioid and CB1
agonist pharmacophores with analgesic activity", a.a. 2015-16.
Principal Investigator: Fondi Di Ateneo per la Ricerca Scientifica (Fondi FAR) Approvati: 5866,87 Euro. Title Progetto: "nuovi ligandi misti ad attività analgesica centrale", a.a. 2016-17.
Principal Investigator: Fondi Di Ateneo per la Ricerca Scientifica (Fondi FAR) Approvati: 7591,0 Euro. Title Progetto: "Nuovi analoghi peptidici ad attività analgesica", a.a. 2017-18.
Principal Investigator: Fondi Di Ateneo per la Ricerca Scientifica (Fondi FAR) Approvati: 6900,0 Euro. Title Progetto: "Nuovi analoghi peptidici ad attività analgesica", a.a. 2018-19.
International Grants
Co-Principal investigator for the International Research and Program Development (IRPD) titled “Determining the Side Effect Profile and Chronic Pain Efficacy of the MACE Series of Fluorinated Cyclic Biphalin Analogs”, grandted 50000$.
Co-Principal investigator: University of Mautitius, grant: MRCI/SCP-A037 : In silico identification of new antiviral pharmacophores from the floral biodiversity and approved phytochemicals in the fight against COVID-19" acronimo:
Phyto-COVID-19
Italian Mministery of Research
Excellence National Funding for Research: MIUR su base valutativa e premiale “FFABR 2017”, per un totale di 3000 euro.
Unit Coordinator of PRIN 2017 2017PHRC8X (650.000 euros granted) (project of National Interest)
Editorial Board and Editor in Chief Position
Chief Editor - of the journal: "Current Bioactive Compounds" Bentham eds
(Indicizzata Scopus) ISSN: 1573-4072 Online: 1875-6646 dal 01-09-2013 till today.
"Editorial Board Member" of the journal: " Protein and Peptide Letters", Bentham ed. (Indicizzata Scopus e WOS) ISSN: 1875-5305 (Online) ISSN: 0929-8665 (Print) from 01-01-2014 till today.
"Editorial Board Member" of the journal: "Mini review in Medicinal Chemistry", Bentham eds. (Indicizzata Scopus e WOS) ISSN: 1875-5607 (Online)
ISSN: 1389-5575 (Print) from 01-01-2015 till today. "Editorial Board Member" of the journal: "International journal of Pharmacy and Pharmaceutical sciences" (Indicizzata Scopus) ISSN: 0975 - 1491
dal 01-01-2015 till today.
"Review Editor" for “Frontiers in Chemistry (Medicinal and Pharmaceutical Chemistry)” ISSN: 2296-2646 (indicizzato scopus) from 01-01-2015 till today.
"Editorial Board Member" of the journal: " Letters in Drug Design & Discovery, "Bentham eds. (Indicizzata Scopus e
WOS) ISSN: ISSN: 1570-1808 (Print) from 1/1/2017 till today.
Editorial Board Memebr of the journal “Scientific Reports” by Nature, from 2019 - till today.
Book: Lezioni di Chimica Farmaceutica, autori vari, Aracne eds.
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ISBN: 978-88-548-8252-2 from 01-09-2015 to 01-09-2015.
PhD Board member for “Biomolecular and Pharmaceutical Sciences” PhD program
2013: [DOT1353593]
(adesione completata il 10/09/2013) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-PESCARA Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE"
Year academic di inizio: 2013 - Ciclo: XXIX - Durata: 3 anni
dal 10-09-2013 till today
2014: [DOT1353593]
(adesione completata il 23/04/2014) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-PESCARA
Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE" Year academic di inizio: 2014/15 - Ciclo: XXX - Durata: 3 years
dal 23-04-2014 tilltoday
2015: [DOT1353593]
(adesione completata il 07/04/2015) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-PESCARA Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE"
Year academic di inizio: 2015/16 - Ciclo: XXXI - Durata: 3 years
dal 07-04-2015 tilltoday
2017
[DOT1353593]
(adesione completata il 15/05/2017) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-
PESCARA Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE"
Year academic di inizio: 2017/18 - Ciclo: - Durata: 3 years
dal 15/05/2017 tilltoday
2018
[DOT1353593] (adesione completata il 22/02/2018) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-
PESCARA
Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE" Year academic di inizio: 2018/2019 - Ciclo: 34)
o Lessons: per il Dottorato "Scienze Biomolecolari e Farmaceutiche" XXIX ciclo University D'Annunzio di Chieti-Pescara,
Lezione di: "Peptidi e Peptidomimetici" lezione tenuta il 20-10-2014 (erogate 2 ore di lezione frontale).
o 2019
[DOT1353594]
(adesione completata il 22/02/2019) Ateneo proponente: University degli Studi "G. d'Annunzio" CHIETI-PESCARA
Titolo: "SCIENZE BIOMOLECOLARI E FARMACEUTICHE"
Year academic di inizio: 2019/20120 - Ciclo: 35)
o 2020
Actual Coordinator for “Biomolecular and Pharmaceutical Sciences” PhD program
Academic Affiliations
Affiliation at Centro di Studio Per La Chimica of Farmaco, CNR, Sezione di Roma c/o Dipartimento di Studi Farmaceutici, University di Roma La Sapienza
(prodotta 1 pubblicazione con questa affiliation, scopus id: 2-s2.0-0036001487) dal 01-09-2001 to 31-10-2001.
Affiliation al: Dipartimento di Chimica, University dell’Arizona, Tucson, AZ, US, (prodotta 1 pubblicazione con questa affiliation scopus id: 2-s2.0-18144421193) from 15-01-2004 to 28-01-2005.
Affiliation all' Istituto di Chimica Biomolecolare, Sezione di Roma, CNR, 00185. (prodotte 2 pubblicazioni con questa affiliation scopus id: 2-s2.0-14044258481; 2-s2.0-33644532888) from 01-09-2005 to 30-04-2006.
Affiliation all’ Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary, prodotta una pubblicazione con questa affiliation, scopus id: 2-s2.0-85039159333. from 1/1/2014.
ISCRIZIONE A SOCIETA’ SCIENTIFICHE:
Member della Società Chimica Italiana, Divisione Chimica Farmaceutica, socio sostenitore, n° iscrizione 15394.
Member della American Chemical Society, n° iscrizione 2417653.
Member della Società italiana Peptidi ItPS.
Member Della Royal Society of Chemistry in Qualità di “Fellow” N° 655571
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Iscrizione all’ Albo Professionale:
Abilitato all’ esercizio della professione di Farmacista (II tornata 2001), e Member dell’Ordine dei Farmacisti di Roma
from 28/1/2002.
PATENTS
Italian Patent RM2015A000091. title: Sintesi enantioselettiva di amminoacidi aromatici non-naturali Inventors: Adriano Mollica; Roberto Costante from 27-02-2015 till today
European Patent, inventors: Adriano Mollica; Roberto Costante TITOLO: ENANTIO-SELECTIVE SYNTHESIS OF NON-NATURAL AMINO ACIDS EP3061753 (A1) from 31-08-
2016 till today.
DEPOSITED Europeo European Patent Application No. 18170728.2 filling date 04/05/2018, Title: Indazole derivatives as modulators of the cannabinoid system. from 04/05/2018. Inventors Csaba Tomboly, Adriano Mollica, Azzurra Stefanucci, Giorgia Macedonio, Dvoracsko szabolcs.
Teaching Activity
a.a. 2006-2007: Assistant at laboratory practice. Laboratori didattici of corso di Analisi dei Farmaci per CTF (40 ore). a.a. 2007-2008: Assistant at laboratory practice of corso di Analisi dei Medicinali I per Farmacia (40 ore).
a.a. 2008-2009: Professor of Pharmaceutical analysis (H-Z) (CFU = 12) (CTF, II year, II semestre). a.a. 2009-2010: Professor of Pharmaceutical analysis II (A-G) (CFU = 12) (Farmacia, III year, II semestre).
a.a. 2010-2011: Professor of Pharmaceutical analysis (A-G) (CFU = 14) (Farmacia, III year, II semestre).
a.a. 2011-2012: Professor of Pharmaceutical analysis (A-G) (CFU = 14) (Farmacia, III year, II semestre). a.a. 2012-2013: Professor of Pharmaceutical analysis (A-G) (CFU = 14) (Farmacia, III year, II semestre).
a.a. 2013-2014: Professor of Pharmaceutical analysis (A-G) (CFU = 14) (Farmacia, III year, II semestre). a.a. 2014-2015:
-Professor of Medicinal Chemistry I. Cdl in CTF, 9 CFU
-Professor of di Chimica dei Professor of Chemistry of cosmetics. 2 CFU
a.a. 2015-2016:
- Professor of Pharmaceutical analysis. I. Cdl in CTF, 9 CFU
- Professor of di Chimica dei Professor of Chemistry of cosmetics. (Chim/08) (corso integrato di biofarmacologia) - Professor of di Professor of Medicinal Chemistry I CdS in CTF, 9 CFU
- Professor of di Chimica dei Professor of Chemistry of cosmetics. (Chim/08) (corso integrato di biofarmacologia), CdS in Tecniche
della prevenzione nell’ ambiente e nei luoghi di lavoro. 2 CFU - Professor of di Internato di laboratorio, corso a scelta, CdS in Farmacia, 3CFU
a.a. 2017-2018: -
Professor of Medicinal Chemistry I I. Cdl in CTF, 9 CFU - Professor of di Chimica dei Professor of Chemistry of cosmetics. (Chim/08) (corso integrato di biofarmacologia), CdS in Tecniche
della prevenzione nell’ ambiente e nei luoghi di lavoro. 2 CFU
- Professor of di Corso a Scelta: Chimica Farmaceutica dei Recettori 3CFU - Professor of di Internato di laboratorio, corso a scelta, CdS in Farmacia, 3CFU
a.a. 2018-2019: (Programmato) Professor of di Chimica Farmaceutica e tossicologica I. Cdl in CTF, 9 CFU
- Professor of di Chimica dei Professor of Chemistry of cosmetics. (Chim/08) (corso integrato di biofarmacologia), CdS in Tecniche della prevenzione nell’ ambiente e nei luoghi di lavoro. 2 CFU
- Professor of di Corso a Scelta: Professor of Medicinal Chemistry of receptors 3CFU, Farmacia IV year.
- Professor of di Internato di laboratorio, corso a scelta, CdS in Farmacia, 3CFU
Tutor for Students Thesys
-from 2009 till today, Il Prof. Adriano Mollica was:
TUTOR of Graduation Thesis di N. 23
Co-Tutor of Graduation Thesys N. 35
-Tutor of Dottorato di N. 3 PhD Student
- Tutor of Post Doc 2017-18, till today.
- “Tutor Universitario” per il “Progetto Formativo e di Orientamento”, degli studenti che svolgono il tirocinio professionale per i
corsi di Studio in Farmacia e Chimica e Tecnologia Farmaceutiche. from 2016 ad today.
Attendance to Schools and workshops
- Attendance at workshop:"Hands-on Workshop: Computer-Aided Drug Design: High Throughtput virtual Screening of Large
Ligand Databases. Bahcesehir University, School of Medicine, Department of Biophysics, Istanbul, Turkey. from 13 to 15 ottobre 2016.
- Attendance at Phd School Scuola Nazionale di Risonanza Magnetica Nucleare, Villa Gualino, Torino from 12/9/2005 to
16/9/2005.
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- Attendance at Phd School: European school of Medicinal Chemistry, XXV advanced course on medicinal chemistry and E.
Duranti National Seminar for PhD students, Urbino 3-7 luglio 2005.
- attendance at Workshop “Giornata di Studio di Scienza delle Separazioni” Shimadzu Italia srl, Marketing Division Shimadzu
Italia , Chieti, 11 ottobre 2013.
Published Papers
Scopus
EXPORT DATE: 28 March 2020
Ahmed, A.A., Mollica, A., Stefanucci, A., Tayrab, E., Ahmed, H., Adam Essa, M.E.
Gum Arabic improves the reproductive capacity through upregulation of testicular glucose transporters (GLUTs) mRNA expression in
Alloxan induced diabetic rat
(2020) Bioactive Carbohydrates and Dietary Fibre, 22, art. no. 100218, .
Stefanucci, A., Dimmito, M.P., Macedonio, G., Ciarlo, L., Pieretti, S., Novellino, E., Lei, W., Barlow, D., Houseknecht, K.L., Streicher, J.M., Mollica, A.
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration
(2020) Journal of Medicinal Chemistry, 63 (5), pp. 2673-2687.
Yagi, S., Mohammed, A.B.A., Tzanova, T., Schohn, H., Abdelgadir, H., Stefanucci, A., Mollica, A., Zengin, G.
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan
(2020) Journal of Food Biochemistry, 44 (2), art. no. e13107, .
Hemati, N., Asis, M., Moradi, S., Mollica, A., Stefanucci, A., Nikfar, S., Mohammadi, E., Farzaei, M.H., Abdollahi, M.
Effects of genistein on blood pressure: A systematic review and meta-analysis
(2020) 128, art. no. 108764, .
Stefanucci, A., Dimmito, M.P., Macedonio, G., Ciarlo, L., Pieretti, S., Novellino, E., Lei, W., Barlow, D., Houseknecht, K.L., Streicher, J.M., Mollica, A.
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration
(2020) .
Stefanucci, A., Lei, W., Pieretti, S., Novellino, E., Dimmito, M.P., Marzoli, F., Streicher, J.M., Mollica, A.
On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity
(2019) 9 (1), art. no. 5771, .
Mahomoodally, M.F., Picot-Allain, C., Hosenally, M., Ugurlu, A., Mollica, A., Stefanucci, A., Llorent-Martínez, E.J., Baloglu, M.C., Zengin, G.
Multi-targeted potential of Pittosporum senacia Putt.: HPLC-ESI-MSn analysis, in silico docking, DNA protection, antimicrobial,
enzyme inhibition, anti-cancer and apoptotic activity
(2019) 83, art. no. 107114, .
Poli, G., Dimmito, M.P., Mollica, A., Zengin, G., Benyhe, S., Zador, F., Stefanucci, A.
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Discovery of novel µ-opioid receptor inverse agonist from a combinatorial library of tetrapeptides through structure-based virtual
screening
(2019) 24 (21), art. no. 3872, .
Dvorácskó, S., Keresztes, A., Mollica, A., Stefanucci, A., Macedonio, G., Pieretti, S., Zádor, F., Walter, F.R., Deli, M.A., Kékesi, G., Bánki, L., Tuboly, G., Horváth, G., Tömböly, C.
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors
(2019) 178, pp. 571-588.
Bibi Sadeer, N., Llorent-Martínez, E.J., Bene, K., Fawzi Mahomoodally, M., Mollica, A., Ibrahime Sinan, K., Stefanucci, A., Ruiz-
Riaguas, A., Fernández-de Córdova, M.L., Zengin, G.
Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three
African medicinal plants
(2019) 174, pp. 19-33.
Dimmito, M.P., Stefanucci, A., Pieretti, S., Minosi, P., Dvorácskó, S., Tömböly, C., Zengin, G., Mollica, A.
Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity
(2019) 9 (9), art. no. 492, .
Saleem, H., Zengin, G., Locatelli, M., Ahmad, I., Khaliq, S., Mahomoodally, M.F., Hussain, R., Rengasamy, K.R.R., Mollica, A., Zainal Abidin, S.A., Ahemad, N.
Pharmacological, phytochemical and in-vivo toxicological perspectives of a xero-halophyte medicinal plant: Zaleya pentandra (L.)
Jeffrey
(2019) 131, art. no. 110535, .
Uysal, S., Senkardes, I., Mollica, A., Zengin, G., Bulut, G., Dogan, A., Glamočlija, J., Soković, M., Lobine, D., Mahomoodally, F.M.
Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
(2019) 37 (12), pp. 3269-3281.
Yeganeh Salehpour, M., Mollica, A., Momtaz, S., Sanadgol, N., Farzaei, M.H.
Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence
(2019) 39 (7), pp. 607-624.
Mahomoodally, M.F., Zengin, G., Zheleva-Dimitrova, D., Mollica, A., Stefanucci, A., Sinan, K.I., Aumeeruddy, M.Z.
Metabolomics profiling, bio-pharmaceutical properties of Hypericum lanuginosum extracts by in vitro and in silico approaches
(2019) 133, pp. 373-382.
Stefanucci, A., Lei, W., Pieretti, S., Dimmito, M.P., Luisi, G., Novellino, E., Nowakowski, M., Koźmiński, W., Mirzaie, S., Zengin, G.,
Streicher, J.M., Mollica, A.
Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: In Vivo and in Vitro Biological Profile
(2019) 10 (4), pp. 450-456.
Saleem, H., Zengin, G., Locatelli, M., Mollica, A., Ahmad, I., Mahomoodally, F.M., Zainal Abidin, S.A., Ahemad, N.
In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive
agents
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(2019) 130, pp. 9-15.
Llorent-Martínez, E.J., Zengin, G., Ortega-Barrales, P., Zakariyyah Aumeeruddy, M., Locatelli, M., Mollica, A., Mahomoodally, M.F.
Characterization of the Phytochemical Profiles and Biological Activities of Ajuga chamaepitys subsp. chia var. chia and Ajuga
bombycina by High-Performance Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry (HPLC–ESI–MS n )
(2019) 52 (5), pp. 852-868.
Trampetti, F., Pereira, C., Rodrigues, M.J., Celaj, O., D'Abrosca, B., Zengin, G., Mollica, A., Stefanucci, A., Custódio, L.
Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme
inhibitory properties, metabolomic profile and computational studies
(2019) 165, pp. 119-128.
Mollica, A., Zengin, G., Durdagi, S., Ekhteiari Salmas, R., Macedonio, G., Stefanucci, A., Dimmito, M.P., Novellino, E.
Combinatorial peptide library screening for discovery of diverse α-glucosidase inhibitors using molecular dynamics simulations and binary QSAR models
(2019) 37 (3), pp. 726-740.
Uysal, A., Ozer, O.Y., Zengin, G., Stefanucci, A., Mollica, A., Picot-Allain, C.M.N., Mahomoodally, M.F.
Multifunctional approaches to provide potential pharmacophores for the pharmacy shelf: Heracleum sphondylium L. subsp. ternatum
(Velen.) Brummitt.
(2019) 78, pp. 64-73.
Zengin, G., Atasagun, B., Zakariyyah Aumeeruddy, M., Saleem, H., Mollica, A., Babak Bahadori, M., Mahomoodally, M.F.
Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A
comprehensive evaluation
(2019) 128, pp. 308-314.
Erdei, A.I., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M.P., Luisi, G., Mollica, A., Benyhe, S.
Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides
(2019) 112, pp. 106-113.
Zengin, G., Stefanucci, A., Rodrigues, M.J., Mollica, A., Custodio, L., Aumeeruddy, M.Z., Mahomoodally, M.F.
Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles
(2019) 162, pp. 225-233.
Mollica, A.
Preface
(2019) 15 (1), p. 2.
Luisi, G., Stefanucci, A., Zengin, G., Dimmito, M.P., Mollica, A.
Anti-oxidant and tyrosinase inhibitory in vitro activity of amino acids and small peptides: New hints for the multifaceted treatment of neurologic and metabolic disfunctions
(2019) 8 (1), art. no. 7, .
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Fakhari, S., Stefanucci, A., Mollica, A., Nikkhoo, B., Tafsiri, E., Jalili, A., Mirzaie, S.
Designing new generation of potent inhibitors against membrane-type matrix metalloproteinase-2: a computational effort against multiple myeloma
(2019) .
Secci, D., Locatelli, M., Kabir, A., Salvatorelli, E., Macedonio, G., Mollica, A., Carradori, S.
Investigation on the stability of new biologically active thiosemicarbazone- derived compounds by a validated HPLC-PDA method
(2019) 15 (3), pp. 313-320.
Stefanucci, A., Dimmito, M.P., Zengin, G., Luisi, G., Mirzaie, S., Novellino, E., Mollica, A.
Discovery of novel amide tripeptides as pancreatic lipase inhibitors by virtual screening
(2019) 43 (7), pp. 3208-3217.
Stefanucci, A., Luisi, G., Zengin, G., Macedonio, G., Dimmito, M.P., Novellino, E., Mollica, A.
Discovery of arginine-containing tripeptides as a new class of pancreatic lipase inhibitors
(2019) 11 (1), pp. 5-19.
Mollica, A., Stefanucci, A., Macedonio, G., Locatelli, M., Luisi, G., Novellino, E., Zengin, G.
Chemical composition and biological activity of Capparis spinosa L. from Lipari Island
(2019) 120, pp. 135-140.
Yagi, S., Mohammed, A.B.A., Tzanova, T., Schohn, H., Abdelgadir, H., Stefanucci, A., Mollica, A., Zengin, G.
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan
(2019) art. no. e13107, .
Taghipour, Y.D., Hajialyani, M., Naseri, R., Hesari, M., Mohammadi, P., Stefanucci, A., Mollica, A., Farzaei, M.H., Abdollahi, M.
Nanoformulations of natural products for management of metabolic syndrome
(2019) 14, pp. 5303-5321.
Sinan, K.I., Bene, K., Zengin, G., Diuzheva, A., Jekő, J., Cziáky, Z., Picot-Allain, C.M.N., Mollica, A., Rengasamy, K.R., Mahomoodally, M.F.
A comparative study of the HPLC-MS profiles and biological efficiency of different solvent leaf extracts of two African plants:
Bersama abyssinica and Scoparia dulcis
(2019) .
Mahomoodally, M.F., Yerlikaya, S., Llorent-Martínez, E.J., Uğurlu, A., Baloglu, M.C., Altunoglu, Y.C., Mollica, A., Dardenne, K.K.,
Aumeeruddy, M.Z., Puchooa, D., Zengin, G.
Pharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. commersonii Müll. Arg: An unexplored endemic species
from Mauritius
(2019) 115, pp. 425-438.
Pippa, S., Mannironi, C., Licursi, V., Bombardi, L., Colotti, G., Cundari, E., Mollica, A., Coluccia, A., Naccarato, V., La Regina, G., Silvestri, R., Negri, R.
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
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(2019) 24 (9), art. no. 1739, .
Baessa, M., Rodrigues, M.J., Pereira, C., Santos, T., da Rosa Neng, N., Nogueira, J.M.F., Barreira, L., Varela, J., Ahmed, H., Asif, S.,
Boukhari, S.A., Kayani, W.K., Ahmad, K.S., Zengin, G., Mollica, A., Custódio, L.
A comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems
(2019) 120, pp. 146-156.
Fawzi Mahomoodally, M., Mollica, A., Stefanucci, A., Zakariyyah Aumeeruddy, M., Poorneeka, R., Zengin, G.
Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A
functional approach
(2018) 126, pp. 13-21.
Zengin, G., Rodrigues, M.J., Abdallah, H.H., Custodio, L., Stefanucci, A., Aumeeruddy, M.Z., Mollica, A., Rengasamy, K.R.R.,
Mahomoodally, M.F.
Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from
Turkey
(2018) 77, pp. 178-186.
Leone, S., Ferrante, C., Recinella, L., Chiavaroli, A., Mollica, A., Tömböly, C., Stefanucci, A., Dimmito, M.P., Dvorácskó, S., Verratti, V., De Petrocellis, L., Orlando, G., Brunetti, L.
Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats
(2018) 72, pp. 38-46.
Mahomoodally, M.F., Atalay, A., Nancy Picot, M.C., Bender, O., Celebi, E., Mollica, A., Zengin, G.
Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations
(2018) 161, pp. 425-435.
Orlando, G., Leone, S., Ferrante, C., Chiavaroli, A., Mollica, A., Stefanucci, A., Macedonio, G., Dimmito, M.P., Leporini, L.,
Menghini, L., Brunetti, L., Recinella, L.
Effects of kisspeptin-10 on hypothalamic neuropeptides and neurotransmitters involved in appetite control
(2018) 23 (12), art. no. 3071, .
Stefanucci, A., Macedonio, G., Dvorácskó, S., Tömböly, C., Mollica, A.
Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators
(2018) 50 (11), pp. 1595-1605.
Mollica, A., Stefanucci, A., Zengin, G., Locatelli, M., Macedonio, G., Orlando, G., Ferrante, C., Menghini, L., Recinella, L., Leone, S.,
Chiavaroli, A., Leporini, L., Di Nisio, C., Brunetti, L., Tayrab, E., Ali, I., Musa, T.H., Musa, H.H., Ahmed, A.A.
Polyphenolic composition, enzyme inhibitory effects ex-vivo and in-vivo studies on two Brassicaceae of north-central Italy
(2018) 107, pp. 129-138.
Zengin, G., Mollica, A., Aumeeruddy, M.Z., Rengasamy, K.R.R., Mahomoodally, M.F.
Phenolic profile and pharmacological propensities of Gynandriris sisyrinchium through in vitro and in silico perspectives
(2018) 121, pp. 328-337.
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Guler, G.O., Zengin, G., Karadag, F., Mollica, A., Picot, C.M.N., Mahomoodally, M.F.
HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts
(2018) 76, pp. 256-263.
Rodrigues, M.J., Vizetto-Duarte, C., Gangadhar, K.N., Zengin, G., Mollica, A., Varela, J., Barreira, L., Custódio, L.
In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma
cells
(2018) 70 (5), pp. 896-899.
Locatelli, M., Yerlikaya, S., Baloglu, M.C., Zengin, G., Altunoglu, Y.C., Cacciagrano, F., Campestre, C., Mahomoodally, M.F., Mollica, A.
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological
perspectives
(2018) 120, pp. 172-182.
Mahomoodally, M.F., Vlaisavljevic, S., Berezni, S., Abdallah, H.H., Zengin, G., Atanasov, A.G., Mollica, A., Lobine, D., Aktumsek, A.
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and
docking on key enzymes linked to global health problems
(2018) 120, pp. 271-278.
Zengin, G., Lobine, D., Mollica, A., Locatelli, M., Carradori, S., Mahomoodally, M.F.
Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays
(2018) 32 (4), pp. 400-413.
Zengin, G., Senkardes, I., Mollica, A., Picot-Allain, C.M.N., Bulut, G., Dogan, A., Mahomoodally, M.F.
New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.
(2018) 75, pp. 111-119.
Stefanucci, A., Zengin, G., Locatelli, M., Macedonio, G., Wang, C.-K., Novellino, E., Mahomoodally, M.F., Mollica, A.
Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.)
(2018) 118, pp. 181-189.
Recinella, L., Chiavaroli, A., Ferrante, C., Mollica, A., Macedonio, G., Stefanucci, A., Dimmito, M.P., Dvorácskó, S., Tömböly, C.,
Brunetti, L., Orlando, G., Leone, S.
Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat
(2018) 70 (4), pp. 650-657.
Mollica, A., Zengin, G., Stefanucci, A., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Locatelli, M., Dimmito, M.P., Novellino, E., Wakeel, O.K., Ogundeji, M.O., Onaolapo, A.Y., Onaolapo, O.J.
Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism
(2018) 47, pp. 562-574.
Remesic, M., Macedonio, G., Mollica, A., Porreca, F., Hruby, V., Lee, Y.S.
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Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors
(2018) 26 (12), pp. 3664-3667.
Stefanucci, A., Mollica, A.
“Breaking bad” television series explained to students
(2018) 52 (3), pp. 342-350.
Mollica, A., Zengin, G., Locatelli, M., Picot-Allain, C.M.N., Mahomoodally, M.F.
Multidirectional investigations on different parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn: Phenolic components, in
vitro biological, and in silico propensities
(2018) 108, pp. 641-649.
Bender, O., Llorent-Martínez, E.J., Zengin, G., Mollica, A., Ceylan, R., Molina-García, L., Luisa Fernández-de Córdova, M., Atalay,
A.
Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of
Hypericum salsugineum: A pharmacologically active source for functional drug formulations
(2018) 13 (6), art. no. e0197815, .
Zengin, G., Ceylan, R., Katanić, J., Aktumsek, A., Matić, S., Boroja, T., Stanić, S., Mihailović, V., Seebaluck-Sandoram, R., Mollica,
A., Mahomoodally, M.F.
Exploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants – Ajuga orientalis L. and Arnebia
densiflora (Nordm.) Ledeb.
(2018) 116, pp. 240-248.
Zengin, G., Bulut, G., Mollica, A., Nancy Picot-Allain, C.M., Mahomoodally, M.F.
In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—An endemic folk medicinal plant
(2018) 73, pp. 120-126.
Uysal, S., Aktumsek, A., Picot-Allain, C.M.N., Unuvar, H., Mollica, A., Georgiev, M.I., Zengin, G., Mahomoodally, M.F.
Biological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutin
(2018) 113, pp. 179-186.
Mocan, A., Zengin, G., Mollica, A., Uysal, A., Gunes, E., Crişan, G., Aktumsek, A.
Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
(2018) 112, pp. 448-457.
Mocan, A., Carradori, S., Locatelli, M., Secci, D., Cesa, S., Mollica, A., Riga, S., Angeli, A., Supuran, C.T., Celia, C., Di Marzio, L.
Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition
(2018) 112, pp. 441-447.
Zengin, G., Aumeeruddy-Elalfi, Z., Mollica, A., Yilmaz, M.A., Mahomoodally, M.F.
In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative
phytopharmaceuticals from nature
(2018) 38, pp. 35-44.
16
Stefanucci, A., Mollica, A., Macedonio, G., Zengin, G., Ahmed, A.A., Novellino, E.
Exogenous opioid peptides derived from food proteins and their possible uses as dietary supplements: A critical review
(2018) 34 (1), pp. 70-86.
Mollica, A.
Preface
(2018) 14 (1), p. 2.
Llorent-Martínez, E.J., Zengin, G., Lobine, D., Molina-García, L., Mollica, A., Mahomoodally, M.F.
Phytochemical characterization, in vitro and in silico approaches for three Hypericum species
(2018) 42 (7), pp. 5204-5214.
Zengin, G., Abdallah, H.H., Dogan, A., Mollica, A., Aumeeruddy-Elalfi, Z., Mahomoodally, M.F.
Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products
(2018) 111, pp. 423-431.
Piekielna-Ciesielska, J., Mollica, A., Pieretti, S., Fichna, J., Szymaszkiewicz, A., Zielińska, M., Kordek, R., Janecka, A.
Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2
(2018) 33 (1), pp. 560-566.
Stefanucci, A., Angeli, A., Dimmito, M.P., Luisi, G., Del Prete, S., Capasso, C., Donald, W.A., Mollica, A., Supuran, C.T.
Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides
(2018) 33 (1), pp. 945-950.
Uysal, S., Ugurlu, A., Zengin, G., Baloglu, M.C., Altunoglu, Y.C., Mollica, A., Custodio, L., Neng, N.R., Nogueira, J.M.F., Mahomoodally, M.F.
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
(2018) 111, pp. 525-536.
Atanasov, A.G., Sabharanjak, S.M., Zengin, G., Mollica, A., Szostak, A., Simirgiotis, M., Huminiecki, Ł., Horbanczuk, O.K., Nabavi, S.M., Mocan, A.
Pecan nuts: A review of reported bioactivities and health effects
(2018) 71, pp. 246-257.
Mollica, A., Macedonio, G., Stefanucci, A., Costante, R., Carradori, S., Cataldi, V., Di Giulio, M., Cellini, L., Silvestri, R., Giordano, C., Scipioni, A., Morosetti, S., Punzi, P., Mirzaie, S.
Arginine- and lysine-rich peptides: Synthesis, characterization and antimicrobial activity
(2018) 15 (3), pp. 220-226.
Stefanucci, A., Novellino, E., Macedonio, G., Dimmito, M.P., Mirzaie, S., Caldas Cardoso, F., Lewis, R., Zádor, F., Erdei, A.I.,
Dvorácskó, S., Tömböly, C., Benyhe, S., Pieretti, S., Minosi, P., Mollica, A.
Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides
(2018) 42 (8), pp. 5656-5659.
17
Zengin, G., Locatelli, M., Stefanucci, A., Macedonio, G., Novellino, E., Mirzaie, S., Dvorácskó, S., Carradori, S., Brunetti, L., Orlando, G., Menghini, L., Ferrante, C., Recinella, L., Chiavaroli, A., Leporini, L., Mollica, A.
Chemical characterization, antioxidant properties, anti-inflammatory activity, and enzyme inhibition of Ipomoea batatas L. leaf
extracts
(2017) 20, pp. 1907-1919.
Mollica, A., Macedonio, G., Stefanucci, A., Carradori, S., Akdemir, A., Angeli, A., Supuran, C.T.
Five- and six-membered nitrogen-containing compounds as selective carbonic anhydrase activators
(2017) 22 (12), art. no. 2178, .
Leone, S., Recinella, L., Chiavaroli, A., Martinotti, S., Ferrante, C., Mollica, A., Macedonio, G., Stefanucci, A., Dvorácskó, S.,
Tömböly, C., De Petrocellis, L., Vacca, M., Brunetti, L., Orlando, G.
Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats
(2017) 69 (6), pp. 1247-1253.
Ferrante, C., Recinella, L., Leone, S., Chiavaroli, A., Di Nisio, C., Martinotti, S., Mollica, A., Macedonio, G., Stefanucci, A., Dvorácskó, S., Tömböly, C., De Petrocellis, L., Vacca, M., Brunetti, L., Orlando, G.
Anorexigenic effects induced by RVD-hemopressin(α) administration
(2017) 69 (6), pp. 1402-1407.
Travaglini, L., Giordano, C., D'Annibale, A., Gubitosi, M., di Gregorio, M.C., Schillén, K., Stefanucci, A., Mollica, A., Pavel, N.V.,
Galantini, L.
Twisted nanoribbons from a RGD-bearing cholic acid derivative
(2017) 159, pp. 183-190.
D'ascenzio, M., Guglielmi, P., Carradori, S., Secci, D., Florio, R., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Supuran, C.T.
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms
(2017) 32 (1), pp. 51-59.
Starnowska, J., Costante, R., Guillemyn, K., Popiolek-Barczyk, K., Chung, N.N., Lemieux, C., Keresztes, A., Van Duppen, J., Mollica,
A., Streicher, J., Vanden Broeck, J., Schiller, P.W., Tourwé, D., Mika, J., Ballet, S., Przewlocka, B.
Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice
(2017) 8 (10), pp. 2315-2324.
Yerlikaya, S., Zengin, G., Mollica, A., Baloglu, M.C., Altunoglu, Y.C., Aktumsek, A.
A multidirectional perspective for novel functional products: In vitro pharmacological activities and in silico studies on Ononis natrix
subsp. hispanica
(2017) 8 (SEP), art. no. 600, .
Zengin, G., Bulut, G., Mollica, A., Haznedaroglu, M.Z., Dogan, A., Aktumsek, A.
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
(2017) 107, pp. 597-608.
18
Rodrigues, M.J., Gangadhar, K.N., Zengin, G., Mollica, A., Varela, J., Barreira, L., Custódio, L.
Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies
(2017) 107, pp. 590-596.
Mollica, A., Zengin, G., Locatelli, M., Stefanucci, A., Macedonio, G., Bellagamba, G., Onaolapo, O., Onaolapo, A., Azeez, F., Ayileka,
A., Novellino, E.
An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats
(2017) 107, pp. 554-564.
Zengin, G., Ceylan, R., Katanić, J., Mollica, A., Aktumsek, A., Boroja, T., Matić, S., Mihailović, V., Stanić, S., Aumeeruddy-Elalfi, Z., Yilmaz, M.A., Mahomoodally, M.F.
Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea
and Moltkia coerulea
(2017) 107, pp. 540-553.
Stefanucci, A., Carotenuto, A., Macedonio, G., Novellino, E., Pieretti, S., Marzoli, F., Szücs, E., Erdei, A.I., Zádor, F., Benyhe, S., Mollica, A.
Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile
(2017) 8 (8), pp. 858-863.
Maccallini, C., Mollica, A., Amoroso, R.
The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases
(2017) 17 (4), pp. 273-281.
Mollica, A., Zengin, G., Locatelli, M., Stefanucci, A., Mocan, A., Macedonio, G., Carradori, S., Onaolapo, O., Onaolapo, A., Adegoke,
J., Olaniyan, M., Aktumsek, A., Novellino, E.
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential
(2017) 35, pp. 32-42.
Zengin, G., Mollica, A., Aktumsek, A., Marie Nancy Picot, C., Fawzi Mahomoodally, M.
In vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge
and scientific validation
(2017) 12, pp. 135-141.
Stefanucci, A., Lei, W., Hruby, V.J., Macedonio, G., Luisi, G., Carradori, S., Streicher, J.M., Mollica, A.
Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers
(2017) 9 (9), pp. 859-869.
Uysal, S., Zengin, G., Locatelli, M., Bahadori, M.B., Mocan, A., Bellagamba, G., Luca, E.D., Mollica, A., Aktumsek, A.
Cytotoxic and enzyme inhibitory potential of two potentilla species (P. speciosa L. and P. reptans Willd.) and their chemical
composition
(2017) 8 (MAY), art. no. 290, .
19
Nescatelli, R., Carradori, S., Marini, F., Caponigro, V., Bucci, R., De Monte, C., Mollica, A., Mannina, L., Ceruso, M., Supuran, C.T.,
Secci, D.
Geographical characterization by MAE-HPLC and NIR methodologies and carbonic anhydrase inhibition of Saffron components
(2017) 221, pp. 855-863.
Stefanucci, A., Novellino, E., Mirzaie, S., Macedonio, G., Pieretti, S., Minosi, P., Szűcs, E., Erdei, A.I., Zádor, F., Benyhe, S., Mollica,
A.
Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge
(2017) 8 (4), pp. 449-454.
Zengin, G., Uysal, A., Aktumsek, A., Mocan, A., Mollica, A., Locatelli, M., Custodio, L., Neng, N.R., Nogueira, J.M.F., Aumeeruddy-Elalfi, Z., Mahomoodally, M.F.
Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations
(2017) 87, pp. 27-36.
Llorent-Martínez, E.J., Zengin, G., de Córdova, M.L.F., Bender, O., Atalay, A., Ceylan, R., Mollica, A., Mocan, A., Uysal, S., Guler,
G.O., Aktumsek, A.
Traditionally used lathyrus species: Phytochemical composition, antioxidant activity, enzyme inhibitory properties, cytotoxic effects,
and In Silico studies of L. Czeczottianus and L. Nissolia
(2017) 8 (FEB), art. no. 83, .
Mollica, A.
Editorial
(2017) 13 (1), p. 2.
Mollica, A.
Meet our editor
(2017) 13 (1), p. 1.
Picot, M.C.N., Zengin, G., Mollica, A., Stefanucci, A., Carradori, S., Mahomoodally, M.F.
In vitro and in silico studies of mangiferin from aphloia theiformis on key enzymes linked to diabetes type 2 and associated complications
(2017) 13 (7), pp. 633-640.
Uysal, S., Aktumsek, A., Picot, C.M.N., Sahan, A., Mollica, A., Zengin, G., Fawzi Mahomoodally, M.
A comparative: In vitro and in silico study of the biological potential and chemical fingerprints of Dorcycinum pentapyllum subsp.
haussknechtii using three extraction procedures
(2017) 41 (22), pp. 13952-13960.
Mocan, A., Zengin, G., Simirgiotis, M., Schafberg, M., Mollica, A., Vodnar, D.C., Crişan, G., Rohn, S.
Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and
computational studies
(2017) 32 (1), pp. 153-168.
Locatelli, M., Cifelli, R., Vitalei, S., Santini, P., de Luca, E., Bellagamba, G., Celia, C., Carradori, S., Marzio, L.D., Mollica, A.
Method validation and hyphenated techniques: Recent trends and future perspectives
20
(2017) pp. 1-22.
Mollica, A., Pelliccia, S., Famiglini, V., Stefanucci, A., Macedonio, G., Chiavaroli, A., Orlando, G., Brunetti, L., Ferrante, C., Pieretti,
S., Novellino, E., Benyhe, S., Zador, F., Erdei, A., Szucs, E., Samavati, R., Dvrorasko, S., Tomboly, C., Ragno, R., Patsilinakos, A.,
Silvestri, R.
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors
(2017) 32 (1), pp. 444-451.
Hosseini, Y., Mollica, A., Mirzaie, S.
Structure-based virtual screening efforts against HIV-1 reverse transcriptase to introduce the new potent non-nucleoside reverse
transcriptase inhibitor
(2016) 1125, pp. 592-600.
Macedonio, G., Stefanucci, A., Maccallini, C., Mirzaie, S., Novellino, E., Mollica, A.
Hemopressin peptides as modulators of the endocannabinoid system and their potential applications as therapeutic tools
(2016) 23 (12), pp. 1045-1051.
Mocan, A., Zengin, G., Crişan, G., Mollica, A.
Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts
(2016) 31, pp. 200-210.
Mollica, A., Locatelli, M., Macedonio, G., Carradori, S., Sobolev, A.P., De Salvador, R.F., Monti, S.M., Buonanno, M., Zengin, G.,
Angeli, A., Supuran, C.T.
Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14
blueberry Italian cultivars
(2016) 31, pp. 1-6.
Luisi, G., Mollica, A., Carradori, S., Lenoci, A., De Luca, A., Caccuri, A.M.
Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione
(2016) 31 (6), pp. 924-930.
Gidaro, M.C., Alcaro, S., Secci, D., Rivanera, D., Mollica, A., Agamennone, M., Giampietro, L., Carradori, S.
Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening
(2016) 31 (6), pp. 1703-1706.
Mollica, A., Mirzaie, S., Costante, R., Carradori, S., Macedonio, G., Stefanucci, A., Dvoracsko, S., Novellino, E.
Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine
(2016) 31 (6), pp. 953-963.
Monti, L., Stefanucci, A., Pieretti, S., Marzoli, F., Fidanza, L., Mollica, A., Mirzaie, S., Carradori, S., De Petrocellis, L., Schiano
Moriello, A., Benyhe, S., Zádor, F., Szűcs, E., Ötvös, F., Erdei, A.I., Samavati, R., Dvorácskó, S., Tömböly, C., Novellino, E.
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates
(2016) 31 (6), pp. 1638-1647.
21
Uysal, A., Zengin, G., Mollica, A., Gunes, E., Locatelli, M., Yilmaz, T., Aktumsek, A.
Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications
(2016) 23 (10), pp. 979-988.
Mocan, A., Zengin, G., Uysal, A., Gunes, E., Mollica, A., Degirmenci, N.S., Alpsoy, L., Aktumsek, A.
Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties
(2016) 25, pp. 94-109.
Secci, D., Carradori, S., Bizzarri, B., Chimenti, P., De Monte, C., Mollica, A., Rivanera, D., Zicari, A., Mari, E., Zengin, G., Aktumsek,
A.
Novel 1,3-thiazolidin-4-one derivatives as promising anti- Candida agents endowed with anti-oxidant and chelating properties
(2016) 117, pp. 144-156.
Mollica, A.
Editorial
(2016) 12 (1), p. 2.
Mollica, A.
Meet our editor
(2016) 12 (1), p. 1.
Carradori, S., Secci, D., De Monte, C., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Codispoti, R., De Cosmi, F., Guglielmi, P.,
Supuran, C.T.
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms
(2016) 24 (5), pp. 1095-1105.
Fantacuzzi, M., Maccallini, C., Di Matteo, M., Ammazzalorso, A., Bruno, I., De Filippis, B., Giampietro, L., Mollica, A., Amoroso, R.
Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC
(2016) 120, pp. 419-424.
Mollica, A., Zengin, G.
Threonine-proline-chimeras, a valuable building block for peptidomimetic design: A review
(2016) 12 (3), pp. 221-228.
Stefanucci, A., Costante, R., Macedonio, G., Dvoracsko, S., Mollica, A.
Cysteine-, methionine- and seleno-cysteine-proline chimeras: Synthesis and their use in peptidomimetics design
(2016) 12 (3), pp. 200-206.
Mollica, A., Costante, R., Mirzaie, S., Carradori, S., Macedonio, G., Stefanucci, A., Novellino, E.
Preparation of Constrained Unnatural Aromatic Amino Acids via Unsaturated Diketopiperazine Intermediate
(2016) 53 (6), pp. 2106-2110.
De Monte, C., Carradori, S., Bizzarri, B., Bolasco, A., Caprara, F., Mollica, A., Rivanera, D., Mari, E., Zicari, A., Akdemir, A., Secci, D.
22
Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives
(2016) 107, pp. 82-96.
Stefanucci, A., Mosquera, J., Vázquez, E., Mascareñas, J.L., Novellino, E., Mollica, A.
Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein
(2015) 6 (12), pp. 1220-1224.
Dvoracsko, S., Stefanucci, A., Novellino, E., Mollica, A.
The design of multitarget ligands for chronic and neuropathic pain
(2015) 7 (18), pp. 2469-2483.
Ammazzalorso, A., Tricca, M.L., Bruno, I., De Filippis, B., Di Matteo, M., Fantacuzzi, M., Giampietro, L., Maccallini, C., Mollica,
A., Amoroso, R.
Titanium-Promoted Acylation of Sulfonamides to N -Acylsulfonamide PPAR Antagonists
(2015) 45 (22), pp. 2546-2554.
De Monte, C., Carradori, S., Secci, D., D'Ascenzio, M., Guglielmi, P., Mollica, A., Morrone, S., Scarpa, S., Aglianò, A.M., Giantulli,
S., Silvestri, I.
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma
(2015) 105, pp. 245-262.
Mollica, A., Costante, R., Akdemir, A., Carradori, S., Stefanucci, A., Macedonio, G., Ceruso, M., Supuran, C.T.
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies
(2015) 23 (17), pp. 5311-5318.
Mollica, A., Costante, R., Stefanucci, A., Novellino, E.
Cyclotides: A natural combinatorial peptide library or a bioactive sequence player?
(2015) 30 (4), pp. 575-580.
De Monte, C., Carradori, S., Gentili, A., Mollica, A., Trisciuoglio, D., Supuran, C.T.
Dual cyclooxygenase and carbonic anhydrase inhibition by nonsteroidal anti-inflammatory drugs for the treatment of cancer
(2015) 22 (24), pp. 2812-2818.
Mollica, A., Costante, R., Stefanucci, A., Novellino, E.
New insight on the synthesis of neurotoxins domoic acid and kainic acid
(2015) 22 (8), pp. 696-711.
Stefanucci, A., Costante, R., Carradori, S., Novellino, E., Mollica, A.
Synthetic strategies for aspartic and glutamic acid-proline chimeras: A review
(2015) 12 (3), pp. 216-236.
23
Carradori, S., Mollica, A., De Monte, C., Granese, A., Supuran, C.T.
Nitric oxide donors and selective carbonic anhydrase inhibitors: A dual pharmacological approach for the treatment of glaucoma,
cancer and osteoporosis
(2015) 20 (4), pp. 5667-5679.
De Monte, C., Bizzarri, B., Gidaro, M.C., Carradori, S., Mollica, A., Luisi, G., Granese, A., Alcaro, S., Costa, G., Basilico, N., Parapini, S., Scaltrito, M.M., Masia, C., Sisto, F.
Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial
and anti-leishmanial agents
(2015) 30 (6), pp. 1027-1033.
Costante, R., Stefanucci, A., Carradori, S., Novellino, E., Mollica, A.
DPP-4 inhibitors: A patent review (2012 - 2014)
(2015) 25 (2), pp. 209-236.
Mollica, A.
Meet our editor
(2015) 11 (1), p. 1.
Mollica, A., Stefanucci, A., Costante, R., Hruby, V.J.
Rational approach to the design of bioactive peptidomimetics: Recent developments in opioid agonist peptides
(2015) 46, pp. 27-68.
Carradori, S., Mollica, A., Ceruso, M., D'Ascenzio, M., De Monte, C., Chimenti, P., Sabia, R., Akdemir, A., Supuran, C.T.
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular
modelling studies
(2015) 23 (13), art. no. 12309, pp. 2975-2981.
Mollica, A., Costante, R., Novellino, E., Stefanucci, A., Pieretti, S., Zador, F., Samavati, R., Borsodi, A., Benyhe, S., Vetter, I., Lewis, R.J.
Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav2.2 Blocker Multitarget Ligands
(2015) 86 (2), pp. 156-162.
Mollica, A., Carotenuto, A., Novellino, E., Limatola, A., Costante, R., Pinnen, F., Stefanucci, A., Pieretti, S., Borsodi, A., Samavati, R.,
Zador, F., Benyhe, S., Davis, P., Porreca, F., Hruby, V.J.
Novel cyclic biphalin analogue with improved antinociceptive properties
(2014) 5 (9), pp. 1032-1036.
Stefanucci, A., Novellino, E., Costante, R., Mollica, A.
Pyroglutamic acid derivatives: Building blocks for drug discovery
(2014) 89 (8), pp. 1801-1825.
24
Costante, R., Pinnen, F., Stefanucci, A., Mollica, A.
Potent biphalin analogs with μ/δ mixed opioid activity: In vivo and in vitro biological evaluation
(2014) 347 (5), pp. 305-312.
Mollica, A., Costante, R., Fiorito, S., Genovese, S., Stefanucci, A., Mathieu, V., Kiss, R., Epifano, F.
Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines
(2014) 98, pp. 91-97.
Mollica, A.
New challenges and opportunities for Current Bioactive Compounds (CBC)
(2013) 9 (3), p. 183.
Mollica, A., Costante, R., Stefanucci, A., Pinnen, F., Luisi, G., Pieretti, S., Borsodi, A., Bojnik, E., Benyhe, S.
Hybrid peptides endomophin-2/DAMGO: Design, synthesis and biological evaluation
(2013) 68, pp. 167-177.
Mollica, A., Stefanucci, A., Costante, R.
Strategies for developing tuberculosis vaccines: Emerging approaches
(2013) 14 (9), pp. 938-951.
Mollica, A., Pinnen, F., Costante, R., Locatelli, M., Stefanucci, A., Pieretti, S., Davis, P., Lai, J., Rankin, D., Porreca, F., Hruby, V.J.
Biological active analogues of the opioid peptide biphalin: Mixed α/β3-peptides
(2013) 56 (8), pp. 3419-3423.
Mollica, A., Costante, R., Stefanucci, A., Pinnen, F., Lucente, G., Fidanza, S., Pieretti, S.
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker
(2013) 19 (4), pp. 233-239.
Mollica, A., Pinnen, F., Stefanucci, A., Costante, R.
The evolution of peptide synthesis: From early days to small molecular machines
(2013) 9 (3), pp. 184-202.
Feliciani, F., Pinnen, F., Stefanucci, A., Costante, R., Cacciatore, I., Lucente, G., Mollica, A.
Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors
(2013) 13 (1), pp. 11-33.
Brunetti, L., Ferrante, C., Orlando, G., Recinella, L., Leone, S., Chiavaroli, A., Di Nisio, C., Shohreh, R., Manippa, F., Ricciuti, A., Mollica, A., Vacca, M.
Orexigenic effects of endomorphin-2 (em-2) related to decreased crh gene expression and increased dopamine and norepinephrine
activity in the hypothalamus
25
(2013) 48, pp. 83-88.
Mollica, A., Feliciani, F., Stefanucci, A., Fadeev, E.A., Pinnen, F.
(Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM
(2012) 19 (12), pp. 1245-1249.
Mollica, A., Pinnen, F., Stefanucci, A., Mannina, L., Sobolev, A.P., Lucente, G., Davis, P., Lai, J., Ma, S.-W., Porreca, F., Hruby, V.J.
Cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: Part 2
(2012) 55 (19), pp. 8477-8482.
Cacciatore, I., Baldassarre, L., Fornasari, E., Mollica, A., Pinnen, F.
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
(2012) art. no. 240146, .
Leone, S., Chiavaroli, A., Orlando, G., Mollica, A., Di Nisio, C., Brunetti, L., Vacca, M.
The analgesic activity of biphalin and its analog AM 94 in rats
(2012) 685 (1-3), pp. 70-73.
Mollica, A., Feliciani, F., Stefanucci, A., Costante, R., Lucente, G., Pinnen, F., Notaristefano, D., Spisani, S.
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues
(2012) 18 (6), pp. 418-426.
Mollica, A., Locatelli, M., Stefanucci, A., Pinnen, F.
Synthesis and bioactivity of secondary metabolites from marine sponges containing dibrominated indolic systems
(2012) 17 (5), pp. 6083-6099.
Mollica, A., Pinnen, F., Stefanucci, A., Feliciani, F., Campestre, C., Mannina, L., Sobolev, A.P., Lucente, G., Davis, P., Lai, J., Ma, S.-
W., Porreca, F., Hruby, V.J.
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues
(2012) 55 (7), pp. 3027-3035.
Locatelli, M., Governatori, L., Carlucci, G., Genovese, S., Mollica, A., Epifano, F.
Recent application of analytical methods to phase I and phase II drugs development: A review
(2012) 26 (3), pp. 283-300.
Mollica, A., Genovese, S., Pinnen, F., Stefanucci, A., Curini, M., Epifano, F.
Ytterbium triflate catalysed Meerwein-Ponndorf-Verley (MPV) reduction
(2012) 53 (7), pp. 890-892.
Mollica, A., Stefanucci, A., Costante, R., Pinnen, F.
Role of formyl peptide receptors (FPR) in abnormal inflammation responses involved in neurodegenerative diseases
(2012) 11 (1), pp. 20-36.
26
Mollica, A., Stefanucci, A., Feliciani, F., Cacciatore, I., Cornacchia, C., Pinnen, F.
Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer
(2012) 9 (2), pp. 122-131.
Cornacchia, C., Cacciatore, I., Baldassarre, L., Mollica, A., Feliciani, F., Pinnen, F.
2,5-Diketopiperazines as neuroprotective agents
(2012) 12 (1), pp. 2-12.
Cacciatore, I., Cornacchia, C., Baldassarre, L., Fornasari, E., Mollica, A., Stefanucci, A., Pinnen, F.
GPE and GPE analogues as promising neuroprotective agents
(2012) 12 (1), pp. 13-23.
Pinnen, F., Cacciatore, I., Cornacchia, C., Mollica, A., Sozio, P., Cerasa, L.S., Iannitelli, A., Fontana, A., Nasuti, C., Di Stefano, A.
CNS delivery of L-dopa by a new hybrid glutathione-methionine peptidomimetic prodrug
(2012) 42 (1), pp. 261-269.
Mollica, A., Stefanucci, A., Feliciani, F., Lucente, G., Pinnen, F.
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry
(2011) 52 (20), pp. 2583-2585.
Stefanucci, A., Pinnen, F., Feliciani, F., Cacciatore, I., Lucente, G., Mollica, A.
Conformationally constrained histidines in the design of peptidomimetics: Strategies for the χ-space control
(2011) 12 (5), pp. 2853-2890.
Pinnen, F., Sozio, P., Cacciatore, I., Cornacchia, C., Mollica, A., Iannitelli, A., Dâaurizio, E., Cataldi, A., Zara, S., Nasuti, C., Di
Stefano, A.
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating alzheimer's disease
(2011) 344 (3), pp. 139-148.
Mollica, A., Pinnen, F., Feliciani, F., Stefanucci, A., Lucente, G., Davis, P., Porreca, F., Ma, S.-W., Lai, J., Hruby, V.J.
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers
(2011) 40 (5), pp. 1503-1511.
Giordano, C., Sansone, A., Masi, A., Lucente, G., Punzi, P., Mollica, A., Pinnen, F., Feliciani, F., Cacciatore, I., Davis, P., Lai, J., Ma,
S.-W., Porreca, F., Hruby, V.
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2
(2010) 45 (10), pp. 4594-4600.
Mollica, A., Feliciani, F., Stefanucci, A., Cacciatore, I., Cornacchia, C., Torino, D., Pinnen, F.
N-(tert)-butyloxycarbonyl-β, β-cyclopentyl-cysteine (acetamidomethyl)-methyl ester for synthesis of novel peptidomimetic
derivatives
(2010) 17 (7), pp. 925-929.
27
Torino, D., Mollica, A., Pinnen, F., Feliciani, F., Lucente, G., Fabrizi, G., Portalone, G., Davis, P., Lai, J., Ma, S.-W., Porreca, F., Hruby, V.J.
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues
(2010) 53 (11), pp. 4550-4554.
77953200832&doi=10.1021%2fjm1001343&partnerID=40&md5=ed30745769d8a03867586c8f54cd0a74
Mollica, A., Stefanucci, A., Feliciani, F., Torino, D., Cacciatore, I., Pinnen, F., Lucente, G.
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone
(2010) 51 (9), pp. 1333-1335.
Cacciatore, I., Cornacchia, C., Pinnen, F., Mollica, A., Di Stefano, A.
Prodrug approach for increasing cellular glutathione levels
(2010) 15 (3), pp. 1242-1264.
Torino, D., Mollica, A., Pinnen, F., Lucente, G., Feliciani, F., Davis, P., Lai, J., Ma, S.-W., Porreca, F., Hruby, V.J.
Synthesis and evaluation of new endomorphin analogues modified at the Pro2 residue
(2009) 19 (15), pp. 4115-4118.
Mura, P., Camalli, M., Campi, G., Lucente, G., Giordano, C., Mollica, A., Sansone, A., Torino, D.
X-ray crystal structure and conformation of N-(tertbutyloxycarbonyl)-L- methionyl-(1-aminocyclopent-3-ene-1-carbonyl)-L-
phenylalanine methyl ester (Boc0-Met1-Cpg2-Phe3-OMe)
(2009) 224 (4), pp. 225-228.
Torino, D., Mollica, A., Pinnen, F., Feliciani, F., Spisani, S., Lucente, G.
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity
(2009) 17 (1), pp. 251-259.
Selvatici, R., Falzarano, S., Franceschetti, L., Mollica, A., Guerrini, R., Siniscalchi, A., Spisani, S.
Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH
(2008) 275 (3), pp. 449-457.
Mollica, A., Guardiani, G., Davis, P., Ma, S.-W., Porreca, F., Lai, J., Mannina, L., Sobolev, A.P., Hruby, V.J.
Synthesis of stable and potent δ/μ opioid peptides: Analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis
(2007) 50 (13), pp. 3138-3142.
Mollica, A., Paglialunga Paradisi, M., Torino, D., Spisani, S., Lucente, G.
Hybrid α/β-peptides: For-Met-Leu-Phe-OMe analogues containing geminally disubstituted β2,2- and β3,3-amino acids at the central position
(2006) 30 (4), pp. 453-459.
Mollica, A., Paradisi, M.P., Varani, K., Spisani, S., Lucente, G.
Chemotactic peptides: fMLF-OMe analogues incorporating proline-methionine chimeras as N-terminal residue
28
(2006) 14 (7), pp. 2253-2265.
Selvatici, R., Falzarano, S., Mollica, A., Spisani, S.
Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils
(2006) 534 (1-3), pp. 1-11.
Aschi, M., Mollica, A., Lucente, G., Paradisi, M.P., Mazza, F.
Conformational properties of β-residue-containing oligopeptides in apolar solvent
(2006) 785 (1-3), pp. 176-181.
Mollica, A., Davis, P., Ma, S.-W., Porreca, F., Lai, J., Hruby, V.J.
Synthesis and biological activity of the first cyclic biphalin analogues
(2006) 16 (2), pp. 367-372.
Mollica, A., Davis, P., Ma, S.-W., Lai, J., Porreca, F., Hruby, V.J.
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers
(2005) 15 (10), pp. 2471-2475.
Morera, E., Nalli, M., Mollica, A., Paradisi, M.P., Aschi, M., Gavuzzo, E., Mazza, F., Lucente, G.
Peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid (Adt): Conformation of Boc-Adt-Adt-NHMe and NH⋯S interactions
(2005) 11 (2), pp. 104-112.
Giordano, C., Lucente, G., Mollica, A., Nalli, M., Zecchini, G.P., Paradisi, M.P., Gavuzzo, E., Mazza, F., Spisani, S.
Hybrid α/β3-petides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe
(2004) 10 (8), pp. 510-523.
Aschi, M., Lucente, G., Mazza, F., Mollica, A., Morera, E., Nalli, M., Paradisi, M.P.
Peptide backbone folding induced by the Cα-tetrasubstituted cyclic α-amino acids 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) and
1-aminocyclopentane-1-carboxylic acid (Ac5c). A joint computational and experimental study
(2003) 1 (11), pp. 1980-1988.
Paradisi, M.P., Mollica, A., Cacciatore, I., Di Stefano, A., Pinnen, F., Caccuri, A.M., Ricci, G., Duprè, S., Spirito, A., Lucente, G.
Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues
(2003) 11 (8), pp. 1677-1683.
Pagani Zecchini, G., Nalli, M., Mollica, A., Lucente, G., Paglialunga Paradisi, M., Spisani, S.
Isopeptide bonds in chemotactic tripeptides. Synthesis and activity of lysine-containing fMLF analogs
(2002) 59 (6), pp. 283-291.
Chieti 19/sept/2020 Adriano Mollica
