CURRICULUM VITAE Joe N. Kornegay, DVM, PhD · Curriculum Vitae Joe N. Kornegay, DVM, PhD Page 2...

Curriculum Vitae Joe N. Kornegay, DVM, PhD

CURRICULUM VITAE Joe N. Kornegay, DVM, PhD

EDUCATION

Institution & Location Degree/Position Major Field Year(s) University of Georgia Ph.D. Veterinary Pathology 1982 University of Georgia Resident Veterinary Pathology 1979-1982 University of Georgia M.S. Veterinary Anatomy 1980 University of Georgia Resident Veterinary Neurology 1976-1979

Texas A&M University D.V.M. Veterinary Medicine 1973 Texas A&M University B.S. Veterinary Science 1972

PROFESSIONAL EXPERIENCE

Institution & Location Position Title Dates Texas A&M University College of Veterinary Medicine & Biomedical Sciences Veterinary Integrative Biosciences Professor 2012-2109 Veterinary Pathobiology Professor 2013-2019 TAMU Institute for Neuroscience Investigator (Faculty) 2012-2019 Texas A&M Institute for Preclinical Studies (TIPS) Director 2014-2016 Center for Cell and Organ Biotechnology (CCOB) Full Participant 2014-2019

Emory University (Atlanta, GA) Adjunct Professor 2017-present School of Medicine Department of Pediatrics (Division of Neurology)

University of North Carolina-Chapel Hill School of Medicine Pathology and Laboratory Medicine Adjunct Professor 2012-2019

Professor 2007-2012 Visiting Research Professor 2006-2007

Neurology Adjunct Professor 2013-2019 Professor 2008-2012

Gene Therapy Center Investigator 2006-2012 Neurodevelopment Disorders Research Center Investigator 2007-2012

University of Missouri-Columbia College of Veterinary Medicine Professor and Dean 1999-2006

Professor and Interim Dean 1998-1999 Veterinary Medicine and Surgery Professor and Chair 1994-1999 (Dr. Cecil Moore named Acting Chair, 5/98 - 1/99) Veterinary Medical Teaching Hospital Director 1994-1999 (Dr. Cecil Moore named Acting Director, 5/98 - 1/99)


Dalton Cardiovascular Research Center Investigator 1994-2006 Doctoral Faculty 2004-2006

North Carolina State University (Raleigh, NC) College of Veterinary Medicine Companion Animal and Special Adjunct Professor 1994-2016 Species Medicine Professor 1986-1993 (Department of Clinical Sciences) Asst. Director of Services 1991-1992

Full graduate faculty 1993 Associate graduate faculty 1983-1993 Associate Professor 1982-1986

University of Georgia (Athens, GA) College of Veterinary Medicine Small Animal Medicine & Surgery Adjunct Professor 2010-present

Resident (Neurology) 1976-1979 MS Student

Veterinary Pathology Resident (Pathology) 1979-1982 PhD Student

Memorial 610 Veterinary Clinic Associate Veterinarian 1974-1976 Houston, TX Weaver Animal Hospital Associate Veterinarian 1973-1974 Perrysburg, OH

HONORS AND AWARDS

Honorary Diplomate, American College of Veterinary Pathologists (ACVP) (2017) Association of American Veterinary Medical Colleges (AAVMC) Recognition Lecturer (2014) Honoris Causa Doctor, University of Liège (Belgium) (2011) Heroes in Medicine Award, American College of Veterinary Internal Medicine (2009) Robert W. Kirk Award for Professional Excellence

American College of Veterinary Internal Medicine (2008) Twelfth International Veterinary Congress Prize

American Veterinary Medical Association (2005) Outstanding Alumnus Award

College of Veterinary Medicine, Texas A&M University (2003) Certificate of Appreciation, Muscular Dystrophy Association (Central Missouri Chapter) (1998) Pfizer Award for Research Excellence, Pfizer Animal Health

College of Veterinary Medicine, University of Missouri-Columbia (1998) Bourgelat Award, British Small Animal Veterinary Association (1995) Teacher of the Year, Presented by Class of 1994 (Junior class, taught clinical neurology)

College of Veterinary Medicine, North Carolina State University (1993) Outstanding Extension Service Award

College of Veterinary Medicine, North Carolina State University (1991)

Curriculum Vitae Joe N. Kornegay, DVM, PhD Teacher of the year, Presented by Class of 1992 (Sophomore class, taught neuropathology) College of Veterinary Medicine, North Carolina State University (1990) Teacher of the year, Presented by Class of 1986 (Junior class, taught clinical neurology) College of Veterinary Medicine, North Carolina State University (1985) Norden Distinguished Teacher Award College of Veterinary Medicine, North Carolina State University (1985) Teacher of the year, Presented by Class of 1985 (Junior class, taught clinical neurology) College of Veterinary Medicine, North Carolina State University (1984) Thomas S. Gathright Academic Excellence Award (1973) Who's Who Among Students in American Universities and Colleges (1973) D.V.M. Degree (Summa Cum Laude), Texas A & M University (1973) Charles John Koerth, Sr. Scholarship (1972) Phi Kappa Phi (1972) B.S. Degree (With High Honors), Texas A & M University (1972) Phi Zeta (1971) Gamma Sigma Delta Award of Merit for Scholarship (1970) Alpha Zeta (1970) Gamma Sigma Delta (1970) Phi Eta Sigma (1969) Danforth Scholarship - American Youth Foundation (1969) BIBLIOGRAPHY Books 4. Lorenz MD, JN Kornegay: Handbook of Veterinary Neurology, 4th Ed, WB Saunders

Co, Philadelphia, 2004. 3. Oliver JE, Jr, MD Lorenz, JN Kornegay: Handbook of Veterinary Neurology, 3rd Ed,

WB Saunders Co, Philadelphia, 1997. 2. Kornegay JN: Feline Neurology. Problems in Veterinary Medicine Series. JB

Lippincott Co, Philadelphia, 1991. 1. Kornegay JN (ed): Neurologic Disorders. Volume 5 of Contemporary Issues in Small

Animal Practice. Churchill Livingstone Inc, New York, 1986. Editorials, Reviews, Chapters 46. Nghiem PP, Kornegay JN. Gene therapies in canine models for Duchenne muscular

dystrophy. Hum Genet. 2019 Feb 7. doi: 10.1007/s00439-019-01976-z. [Epub ahead of print].

45. Kornegay JN. The golden retriever model of Duchenne muscular dystrophy.

Skelet Muscle May 19;7(1):9, 2017. doi: 10.1186/s13395-017-0124-z.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 44. Kornegay JN, MK Childers: Canine inherited dystrophinopathies and centronuclear

myopathies. In: Childers MK (ed). Regenerative Medicine for Degenerative Muscle Diseases. Series Title: Stem Cell Biology and Regenerative Medicine, Humana Press, New York, 2016, 309-9.

43. Fan Z, J Kornegay, X Xiao, W Powers: Pressurized transvenous-retrograde extremity

perfusion. In: Tempelton NS (ed). Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Ed. CRC Press, London, 2015, 439-50. doi: 10.1201/b18002-20.

42. Kornegay JN, CF Spurney, PP Nghiem, CL Brinkmeyer-Langford, EP Hoffman, K

Nagaraju. Pharmacologic management of Duchenne muscular dystrophy: Target identification and preclinical trials. ILAR Journal 55:119-49, 2014. doi: 10.1093/ilar/ilu011.

41. Brinkmeyer-Langford C, JN Kornegay: Comparative genomics of X-linked muscular

dystrophies: The golden retriever model. Curr Genomics 14:330-42, 2013. 40. Kornegay JN, JR Bogan, DJ Bogan, MK Childers, J Li, P Nghiem, DA Detwiler, CA

Larsen, RW Grange, RK Bhavaraju-Sanka, S Tou, BP Keene, JF Howard, Jr, J Wang, Z Fan, SJ Schatzberg, MA Styner, KM Flanigan, X Xiao, EP Hoffman: Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mamm Genome 23:85-108, 2012. doi: 10.1007/s00335-011-9382-y.

39. Kornegay JN, MK Childers, DJ Bogan, JR Bogan, P Nghiem, J Wang, Z Fan, JF

Howard, Jr, SJ Schatzberg, JL Dow, RW Grange, MA Styner, EP Hoffman, KR Wagner. The paradox of muscle hypertrophy in muscular dystrophy. In: Carter GT (ed). Recent Advancements in Neuromuscular Medicine. Phys Med Rehabil Clin N Am 23:149-72, 2012. doi: 10.1016/j.pmr.2011.11.014.

38. Kornegay JN, JR Bogan, DJ Bogan, MK Childers, RW Grange: Golden retriever

muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements. In: Duan D (ed). Muscle Gene Therapy: Methods and Protocols. Methods in Molecular Biology, vol. 709, Humana Press, New York, 2011, 105-123. doi: 10.1007/978-1-61737-982-6_7.

37. Han JJ, GT Carter, MD Weiss, C Shekar, JN Kornegay: Using electromyography to

assess function in humans and animal models of muscular dystrophy. Phys Med Rehabil Clin N Am, 2005, 981-97.

36. Kornegay JN: The nervous system. In: Hoskins, JD (ed). Veterinary Pediatrics, 2nd Ed.

WB Saunders Co, Philadelphia, 1995, 451-96. 35. Kornegay JN: Disorders of the skeletal muscles. In: Ettinger SJ and Feldman EC (eds).

Textbook of Veterinary Internal Medicine. Diseases of the Dog and the Cat, WB Saunders Co, Philadelphia, 1995, 727-36.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 34. Kornegay JN: History, neurologic examination, and localization of lesions. J Vet Med

(Japanese) 47:647-54, 1994. 33. Bagley RS, JN Kornegay, RL Page, DE Thrall: Central nervous system neoplasia. In:

Slatter DH (ed). Textbook of Small Animal Surgery, WB Saunders Co, Philadelphia, 1993, 2137-66.

32. Kornegay JN: Diskospondylitis. In: Slatter DH (ed). Textbook of Small Animal

Surgery, WB Saunders Co, Philadelphia, 1993, 1087-94. 31. Kornegay JN: Pathogenesis of diseases of the central nervous system. In: Slatter DH

(ed). Textbook of Small Animal Surgery, WB Saunders Co, Philadelphia, 1993, 1022-37.

30. Kornegay JN: The X-linked muscular dystrophies. In: Kirk RW and Bonagura JD

(eds). Current Veterinary Therapy XI, WB Saunders Co, Philadelphia, 1992, 1042-7. 29. Kornegay JN: Intervertebral disk disease: Treatment guidelines. In: Kirk RW and

Bonagura JD (eds). Current Veterinary Therapy XI, WB Saunders Co, Philadelphia, 1992, 1013-8.

28. Lane SB, JN Kornegay: Spinal lymphosarcoma. In: August, JR (ed). Consultations in

Feline Internal Medicine, WB Saunders Co, Philadelphia, 1991, 487-90. 27. Kornegay JN: Cerebellar hypoplasia. In: August, JR (ed). Consultations in Feline

Internal Medicine, WB Saunders Co, Philadelphia, 1991, 503-6. 26. Kornegay JN: Ataxia of the head and limbs: Cerebellar diseases in dogs and cats. Prog

Vet Neurol 1:255-74, 1990. 25. Kornegay JN, Anson LW: The musculoskeletal system. In: Greene CE, Infectious

Diseases of the Dog and Cat, 2nd Ed., WB Saunders Co, Philadelphia, 1990, 84-96. 24. Kornegay JN: The nervous system. In: Hoskins, JD (ed). Veterinary Pediatrics, WB

Saunders Co, Philadelphia, 1990, 95-137. 23. Kornegay JN: Imaging brain neoplasms. Computed tomography and magnetic

resonance imaging. Vet Med Rep 2:372-90, 1990. 22. Kornegay JN, CE Thomson: Trembling and shivering. In: Ettinger, SJ (ed). Textbook

of Veterinary Internal Medicine, 3rd Ed., WB Saunders Co, Philadelphia, 1989, 54-6. 21. Kornegay JN, SB Lane: Seizures. In: Ettinger, SJ (ed). Textbook of Veterinary Internal

Medicine, 3rd Ed., WB Saunders Co, Philadelphia, 1989, 67-9.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 20. Kornegay JN: Congenital cerebellar diseases. In: Kirk, RW (ed), Current Veterinary

Therapy X, WB Saunders Co, Philadelphia, 1989, 838-41. 19. Kornegay JN, IG Mayhew: Metabolic diseases of the nervous system. In: Oliver, JE,

Hoerlein, BF and Mayhew, IG (eds). Veterinary Neurology, WB Saunders Co, Philadelphia, 1987, 255-77.

18. Kornegay JN: Vertebral diseases of large breed dogs. In: Kornegay, JN (ed).

Neurologic Disorders. Volume 5 of Contemporary Issues in Small Animal Practice. Churchill Livingstone Inc, New York, 1986, 197-215.

17. Kornegay JN: Congenital and degenerative diseases of the central nervous system. In:

Kornegay, JN (ed). Neurologic Disorders. Volume 5 of Contemporary Issues in Small Animal Practice. Churchill Livingstone Inc, New York, 1986, 109-29.

16. Kornegay JN: Central nervous system neoplasia. In: Kornegay, JN (ed). Neurologic

Disorders. Volume 5 of Contemporary Issues in Small Animal Practice. Churchill Livingstone Inc, New York, 1986, 79-108.

15. Kornegay JN: Management of animals with neurologic dysfunction. In: Kornegay, JN

(ed). Neurologic Disorders. Volume 5 of Contemporary Issues in Small Animal Practice. Churchill Livingstone Inc, New York, 1986, 1-19.

14. Kornegay JN: Diskospondylitis. In: Kirk, RW (ed). Current Veterinary Therapy IX,

WB Saunders Co, Philadelphia, 1986, 810-4. 13. Kornegay JN: Golden retriever myopathy. In: Kirk, RW (ed). Current Veterinary

Therapy IX, WB Saunders Co, Philadelphia, 1986, 792-4. 12. Kornegay JN: Intervertebral disk disease: Treatment guidelines. Tx Vet Med J 48:29-

35, 1986. 11. Kornegay JN: Diskospondylitis. In: Slatter, DH (ed). Textbook of Small Animal

Surgery, WB Saunders Co, Philadelphia, 1985, 1391-4. 10. Kornegay JN: Lesions of the lumbosacral intumescence and cauda equina. In: Slatter,

DH (ed). Textbook of Small Animal Surgery, WB Saunders Co, Philadelphia, 1985, 1339-46.

9. Kornegay JN: Pathogenesis of central nervous system disease. In: Slatter, DH (ed).

Textbook of Small Animal Surgery, WB Saunders Co, Philadelphia, 1985, 1266-85. 8. Kornegay JN: Musculoskeletal infections. In: Greene, CE (ed). Clinical Microbiology

and Infectious Diseases of the Dog and Cat, WB Saunders Co, Philadelphia, 1984, 208-19.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 7. Kornegay JN: Diskospondylitis. In: Kirk, RW (ed). Current Veterinary Therapy VIII,

WB Saunders Co, Philadelphia, 1983, 718-21. 6. Kornegay JN: Hypocalcemia in dogs. Compend Contin Educ Pract Vet 4:103-12, 1982. 5. Kornegay JN: Feline neurology. Compend Contin Educ Pract Vet 3:203-14, 1981. 4. Kornegay JN: Cerebrospinal fluid collection, examination, and interpretation in dogs

and cats. Compend Contin Educ Pract Vet 3:85-94, 1981. 3. Kornegay JN: Small animal neuroophthalmology. Compend Contin Educ Pract Vet

2:923-8, 1980. 2. Kornegay JN: Ischemic myelopathy due to fibrocartilaginous embolism. Compend

Contin Educ Pract Vet 2:402-6, 1980. 1. Kornegay JN: Canine diskospondylitis. Compend Contin Educ Pract Vet 1:930-4,

1979. In Press/Accepted/Submitted Original/Review Papers in Refereed Journals 3. Simpson RM, SB Hoover, BJ Davis, J Hickerson, MA Miller, M Kiupel, JM Cullen, JE

Dwyer, Bih-Rong W, TJ Rosol, JN Kornegay, SK Samal: Synergistic inter-institutional

one health collaborations prepare veterinary scientist investigators within the National Institutes of Health Comparative Biomedical Scientist Training Program. Submitted.

2. Mata López S, C Balog-Alvarez, EH Canessa, Y Hathout, KJ Brown, S Vitha, AK Bettis,

J Boehler, JN Kornegay, PP Nghiem: Creation and characterization of an immortalized canine myoblast cell line: Myok9. Submitted.

1. Alic L, JF Griffin IV, A Eresen, JN Kornegay, JX Ji: Using MRI to quantify skeletal

muscle pathology in Duchenne muscular dystrophy: A systematic review. Submitted. Original Papers in Refereed Journals 142. Song Y, L Morales, AS Malik, AF Mead, CD Greer, MA Mitchell, MT Petrov, LT Su,

ME Choi, ST Rosenblum, X Lu, DJ VanBelzen, RK Krishnankutty, FJ Balzer, E Loro, R French, KJ Propert, S Zhou, BW Kozyak, PP Nghiem, TS Khurana, JN Kornegay, HH Stedman. Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models. Nat Med. 2019 Oct 7. doi: 10.1038/s41591-019-0594-0. [Epub ahead of print].

141. Guo L-J, JH Soslow, AK Bettis, KJ Cummings, MW Lenox, MW Miller, JN Kornegay, CF Spurney: Natural history of cardiomyopathy in adult dogs with golden retriever muscular dystrophy. J Am Heart Assoc 2019;8:e012443. doi: 10.1161/JAHA.119.012443

Curriculum Vitae Joe N. Kornegay, DVM, PhD 140. Eresen A, NE Hafsa, L Alic, SM Birch, JF Griffin IV, JN Kornegay, JX Ji: Muscle

percentage index as a marker of disease severity in golden retriever muscular dystrophy. Muscle Nerve 2019 Aug 9. doi: 10.1002/mus.26657 [Epub ahead of print].

139. Barraza-Flores P, TM Fontelonga, RD Wuebbles, HJ Hermann, JN Kornegay, DJ

Burkin. Laminin-111 protein therapy enhances muscle regeneration in the GRMD dog model of Duchenne muscular dystrophy. Hum Mol Genet. 2019 Apr 24. pii: ddz086. doi: 10.1093/hmg/ddz086. [Epub ahead of print].

138. Eresen A, L Alic, SM Birch, W Friedeck, JF Griffin 4th, JN Kornegay, JX Ji:

Texture as an imaging biomarker for disease severity in golden retriever muscular dystrophy. Muscle Nerve. 2018 Nov 21. doi: 10.1002/mus.26386. [Epub ahead of print].

137. Eresen A, L Alic, J Kornegay, JX Ji: Assessment of disease severity in a canine model

of Duchenne muscular dystrophy: Classification of quantitative MRI. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:648-51. doi: 10.1109/EMBC.2018.8512303.

136. Haddix SG, YI Lee, JN Kornegay, WJ Thompson: Cycles of myofiber degeneration and

regeneration lead to remodeling of the neuromuscular junction in two models of Duchenne muscular dystrophy. PLoS One. 2018 Oct 31;13(10):e0205926. doi: 10.1371/journal.pone.0205926.

135. Eresen A, SM Birch, L Alic, JF Griffin IV, JN Kornegay, JX Ji: New similarity metric

for registration of MRI to histology: Golden retriever muscular dystrophy imaging. IEEE Trans Biomed Eng. 2018 Sep 17. doi: 10.1109/TBME.2018.2870711.

134. Mata López S, JJ Hammond, MB Rigsby, CJ Balog-Alvarez, JN Kornegay, PP Nghiem:

Single nucleotide deletion in exon 20: a novel canine model for Duchenne muscular dystrophy. Skelet Muscle 2018 May 29;8(1):16. doi: 10.1186/s13395-018-0162-1.

133. Brinkmeyer-Langford C, C Chu, C Balog, M Nabity, J Kornegay: Expression profiling

of disease progression in a canine model of Duchenne muscular dystrophy. PLoS One. 2018 Mar 19;13(3):e0194485. doi: 10.1371/journal.pone.0194485. eCollection 2018.

132. Stoughton WB, J Li, C Balog-Alvarez C, JN Kornegay: Autophagy is disordered in the

golden retriever model of Duchenne muscular dystrophy. Muscle Nerve. 58:418-26, 2018. doi: 10.1002/mus.26121.

131. Schneider SM, V Sridhar, AK Bettis, H Heath-Barnett, CJ Balog-Alvarez, J Guo, JS

Jacques, R Johnson, S Vitha, AC Glowcwski, JN Kornegay, PP Nghiem: Glucose metabolism as a pre-clinical biomarker for the golden retriever model of Duchenne muscular dystrophy. Mol Imaging Biol 20:780-8, 2018. doi: 10.1007/s11307-018-1174-2.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 130. van Putten M, A Aartsma-Rus, MD Grounds, JN Kornegay, A Mayhew, TH

Gillingwater, S Takeda, MA Rüegg, A De Luca, K Nagaraju, R Willmann: Update on standard operating procedures in preclinical research for DMD and SMA. Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands. J Neuromuscul Dis. 2018;5(1):29-34. doi: 10.3233/JND-170288.

129. Eresen A, S McConnell, SM Birch, JF Griffin, JN Kornegay, JX Ji: Tissue classification

in a canine model of Duchenne muscular dystrophy using quantitative MRI parameters. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4066-4069. doi: 10.1109/EMBC.2017.8037749.

128. Nghiem PP, L Bello, WB Stoughton, AH Vidal, BV Hernandez, KN Hulbert, TR

Gourley, AK Bettis, CJ Balog-Alvarez, H Heath-Barnett, JN Kornegay: Changes in muscle metabolism are associated with phenotypic variability in Duchenne and golden retriever muscular dystrophy. Yale J Biol Med 90:351-60, 2017. eCollection 2017 Sep.

127. Abdullah M, JN Kornegay, A Honcoop, TL Parry, CJ Balog-Alvarez, SK O'Neal, JR

Bain, MJ Muehlbauer, CB Newgard, C Patterson, MS Willis: Non-targeted metabolomics analysis of golden retriever muscular dystrophy-affected muscles reveals alterations in arginine and proline metabolism, and elevations in glutamic and oleic acid in vivo. Metabolites Jul 29;7(3). Pil:E38.; doi:10.3390/metabo7030038.

126. Nghiem PP, JN Kornegay, K Uaesoontrachoon, L Bello, Y Yin, Z Wang, A Kesari, P

Mittal, SJ Schatzberg, G Many, NH Lee, EP Hoffman: Osteopontin modulates myostatin expression via AKT1 and FoxO1 pathways. Muscle Nerve 26:1110-27, 2017. doi: 10.1002/mus.25752.

125. Markham LW, CL Brinkmeyer-Langford, JH Soslow, S Sengsayadeth, DB Sawyer, JN

Kornegay, CL Galindo: GRMD cardiac and skeletal muscle metabolism gene profiles are distinct. BMC Med Genomics. 2017 Apr 8;10(1):21. doi: 10.1186/s12920-017-0257-2.

124. Nghiem PP, L Bello L, C Balog C, SJ Schatzberg, RJ Piercy, SM Lopez, A Bettis, JN

Kornegay: Whole genome next generation sequencing reveals a deletion in exon 42 in the DMD gene of a Cavalier King Charles Spaniel dog. Mamm Genome. 28:106-13, 2017. doi: 10.1007/s00335-016-9675-2.

123. VanBelzen DJ, AS Malik, PS Henthorn, JN Kornegay, HH Stedman: Mechanism of

deletion removing all dystrophin exons in a canine model for DMD implicates concerted evolution of X chromosome pseudogenes. Mol Ther Methods Clin Dev. 2016 Dec 24;4:62-71. doi: 10.1016/j.omtm.2016.12.001.

122. Eresen A, S McConnell, SM Birch, JF Griffin, JN Kornegay, JX Ji: Localized MRI and

histological image correlation in a canine model of Duchenne muscular dystrophy. Conf Proc IEEE Eng Med Biol Soc. 2016. Aug;2016:4083-4086. doi: 10.1109/EMBC.2016.7591624.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 121. Acosta AR, E Van Wie, WB Stoughton, AK Bettis, HH Barnett, NR LaBrie, CJ Balog-

Alvarez, PP Nghiem, KJ Cummings, JN Kornegay: Use of the six-minute walk test to characterize golden retriever muscular dystrophy. Neuromuscul Disord 26:865-72, 2016. doi: 10.1016/j.nmd.2016.09.024.

120. Brinkmeyer-Langford C, C Balog-Alvarez, JJ Cai, BW Davis, JN Kornegay: Genome-

wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy. BMC Genomics 2016 Aug 22;17:665. doi: 10.1186/s12864-016-2948-z.

119. Birch SM, MW Lenox, JN Kornegay, B Paniagua, MA Styner, CR Goodlett, TA Cudd,

SE Washburn: Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs. Alcohol 55:1-8, 2016. doi: 10.1016/j.alcohol.2016.07.004.

118. Many GM, Y Yokosaki, K Uaesoontrachoon, PP Nghiem, L Bello, S Dadgar, Y Yin, JM

Damsker, HB Cohen, JN Kornegay, MM Bamman, DM Mosser, K Nagaraju, EP Hoffman: OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages. Exp Physiol 101:1285-300, 2016. doi: 10.1113/EP085768.

117. Schneider SM, AE Coleman, L-J Guo, S Tou, BW Keene, JN Kornegay: Suspected

acute myocardial infarction in a dystrophin-deficient dog. Neuromuscul Disord 26:361-6, 2016. doi: 10.1016/j.nmd.2016.02.005.

116. Kornegay JN, DJ Bogan, JR Bogan, JL Dow, J Wang, Z Fan, N Liu, LC Warsing, RW

Grange, M Ahn, CJ Balog-Alvarez, SW Cotten, SW Willis, C Brinkmeyer-Langford, H Zhu, J Palandra, CA Morris, MA Styner, KR Wagner: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. Skelet Muscle. 2016 Apr 4;6:14. doi: 10.1186/s13395-016-0085-7.

115. Galindo CL, JH Soslow, CL Brinkmeyer-Langford, M Gupte, HM Smith, S

Sengsayadeth, DB Sawyer DB, DW Woodrow, JN Kornegay, LW Markham: Translating golden retriever muscular dystrophy (GRMD) microarray findings to novel biomarkers for cardiac and skeletal muscle function in Duchenne muscular dystrophy. Pediatr Res. 2016 Apr;79(4):629-36. doi: 10.1038/pr.2015.257.

114. Birch S, M Lenox, J Kornegay, L Shen, A Huisi, X Ren, CR Charles R. Goodlet, T

Cudd, S Washburn: Computed tomography assessment of adolescent ovine craniofacial development in a first trimester binge drinking model. Alcohol 49:675-89, 2015. doi: 10.1016/j.alcohol.2015.08.007.

113. Fiorillo AA, CR Heier, KR Brown, K Uaesoontrachoon, PP Ngheim, L Bello, JN

Kornegay, C Angelini, TA Partridge, K Nagaraju, EP Hoffman: Pathology-associated microRNAs modify dystrophin protein levels in both Becker muscular dystrophy and exon skipping therapy. Cell Rep 8:1678-90, 2015. doi: 10.1016/j.celrep.2015.07.066.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 112. Kornegay JN, JM Peterson, DJ Bogan, W Kline, JR Bogan, JL Dow, Z Fan, J Wang, M

Ahn, H Zhu, M Styner, DC Guttridge: NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy. Skelet Muscle 4:18, 2014. doi: 10.1186/2044-5040-4-18.

111. Martin PT, B Golden, J Okerblom, M Camboni, K Chandrasekharan, R Xu, A Varki, KM

Flanigan, JN Kornegay: A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. PLoS ONE 2014, 9(2): e88226. doi:10.1371/journal.pone.0088226.

110. Mead AF, A Malik, M Petrov, M Childers, J Bogan, G Seidner, JN Kornegay, HH

Stedman: Integrative biology of respiratory failure in a translational model for Duchenne muscular dystrophy. J Appl Physiol (1985)116:807-815, 2014. doi: 10.1152/applphysiol.00833.2013.

109. DeVanna JC, JN Kornegay, DJ Bogan, JR Bogan, JL Dow, EC Hawkins: Assessment of

respiratory dysfunction in dogs with golden retriever muscular dystrophy: Arterial blood gas analysis and tidal breathing spirometry. Neuromuscul Disord 24:63-73, 2014. Doi: 10.1016/j.nmd.2013.10.001.

108. Fan Z, J Wang, M Ahn, Y Shiloh-Malawsky, N Chahin, S Elmore, CR Bagnell, Jr, K

Wilber, H An, W Lin, H Zhu, M Styner, JN Kornegay: Characteristics of magnetic resonance imaging biomarkers in a natural history study of golden retriever muscular dystrophy. Neuromuscul Disord 24:178-91, 2014. doi: 10.1016/j.nmd.2013.10.005.

107. Cotten SW, JN Kornegay, DJ Bogan, KM Wadosky, C Patterson, MS Willis: Genetic

myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease. Am J Transl Res 16:43-53, 2013.

106. Nghiem PP, EP Hoffman, P Mittal, K Brown, SJ Schatzberg, S Ghimbovschi, Z Wang,

JN Kornegay: Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs. Am J Pathol 183:1411-1424, 2013. doi: 10.1016/j.ajpath.2013.07.013.

105. RD Wuebbles, A Sarathy, JN Kornegay, DJ Burkin: Prednisone increases a7 integrin

and laminin-a2 in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy. Dis Model Mech 6:1175-84, 2013. doi: 10.1242/dmm.012211.

104. Wang J, Z Fan, K Vandenborne, G Walter, Y Shiloh-Malawsky, H An, JN Kornegay,

MA Styner: A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy. Int J Comput Assist Radiol Surg 8:763-74, 2013. doi: 10.1016/j.nmd.2013.10.005.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 103. Kane AM, TC DeFrancesco, MC Boyle, DE Malarkey, JW Ritchey, CE Atkins, JM

Cullen, JN Kornegay, BW Keene: Cardiac structure and function in female carriers of a canine model of Duchenne muscular dystrophy. Res Vet Sci 94:610-7, 2013. doi: 10.1016/j.rvsc.2012.09.027.

102. Barbash IM, S Cecchini, AZ Faranesh, T Virag, L Li, RF Hoyt, JN Kornegay, JR

Bogan, L Garcia, RJ Lederman, RM Kotin: MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of DMD. Gene Ther 20:274-82, 2013. doi: 10.1038/gt.2012.38.

101. Sunico SK, C Hamel, M Styner, ID Robertson, JN Kornegay, C Bettini, J Parks, K

Wilber, JE Smallwood, DE Thrall: Two anatomic resources of canine pelvic limb muscles based on CT and MRI. Vet Radiol Ultrasound 53:266-72, 2012. doi: 10.1111/j.1740-8261.2012.01926.x.

100. Bish LT, MM Sleeper, SC Forbes, B Wang, C Reynolds, GE Singletary, D Trafny, KJ

Morine, J Sanmiguel, S Cecchini, T Virag, A Vulin, C Beley, J Bogan, JM Wilson, K Vendenborne, JN Kornegay, GA Walter, RM Kotin, L Garcia, HL Sweeney: Long-term restoration of cardiac expression in golden retriever muscular dystrophy following rAAV-6 mediated exon skipping. Mol Ther 20:580-9, 2012. doi: 10.1038/mt.2011.264.

99. Detwiler D, N Dobes, CE Sims, JN Kornegay, NL Allbritton: Modification of

micropallet surfaces for culture of muscle progenitor cells. Anal Bioanal Chem 402:1083-91, 2012. doi: 10.1007/s216-011-5596-9.

98. Childers MK, JR Bogan, DJ Bogan, H Greiner, J Staley, M Holder, RW Grange, JN

Kornegay: Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy. Front Pharmacol 2:89, 2011. doi: 10.3389/fphar.2011.00089.

97. Wadosky KM, L Li, JE Rodríguez, J Min, D Bogan, J Gonzalez, JN Kornegay, M

Willis: Regulation of the calpain and ubiquitin proteasome systems in a canine model of Duchenne muscular dystrophy. Muscle Nerve 44:553-62, 2011. doi: 10.1002/mus.22125.

96. Bish LT, MM Sleeper, SC Forbes, KJ Morine, C Reynolds, GE Singletary, D Trafny, J

Bogan, JN Kornegay, GA Walter, HL Sweeney: Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy. Hum Gene Ther 12:1499-509, 2011. doi: 10.1089/hum.2011.102.

95. Childers MK, RW Grange, JN Kornegay: In Vivo Canine Muscle Function Assay. J Vis

Exp (50), e2623, 2011. doi: 10.3791/2623.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 94. Peterson JM, W Kline, BD Canan, DJ Ricca, B Kaspar, DA Delfín, K DiRienzo, PR

Clemens, PD Robbins, AS Baldwin, P Flood, P Kaumaya, M Frietas, JN Kornegay, JR Mendell, JA Rafael-Fortney, DC Guttridge, PML Janssen: Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in the mdx murine model of Duchenne muscular dystrophy. Mol Med 17:508-15, 2011. doi: 10.2119/molmed.2010.00263.

93. Miyazato LG, JRE Moraes, DC Baretta, JN Kornegay: Muscular dystrophy in dogs:

Does the crossing of different breeds influence disease phenotype? Vet Pathol 48:655-62, 2011. doi: 10.1177/0300985810387070.

92. NJ Olby, NJH Sharp, BW Keene, PP Nghiem, TC DeFrancesco, J Sidley, JN Kornegay,

SJ Schatzberg: Clinical progression of X-linked muscular dystrophy in two German short haired pointers. J Am Vet Med Assoc 238:207-12, 2011. doi: 10.2460/javma.238.2.207.

91. Smith BF, Y Yue, PR Woods, JN Kornegay, J-H Shin, RR Williams, D Duan: An

intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed. Lab Invest 91:216-31, 2011. doi: 10.1038/labinvest.2010.146.

90. Kornegay JN, J Li, JR Bogan, DJ Bogan, C Chen, H Zheng, B Wang, C Qiao, JF

Howard, Jr, X Xiao: Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs. Mol Ther 18:1501-8, 2010. doi: 10.1038/mt.2010.94.

89. Tegeler CJ, RW Grange, DJ Bogan, CD Markert, D Case, JN Kornegay, MK Childers:

Eccentric contractions induce rapid isometric torque drop in dystrophic-deficient dogs. Muscle Nerve 42:130-2, 2010. doi: 10.1002/mus.21699.

88. Townsend D, I Turner, S Yasuda, J Martindale, J Davis, M Shillingford, JN Kornegay,

JM Metzger: Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs. J Clin Invest 120:1140-50, 2010. doi: 10.1172/JCI41329.

87. Pichavant C, P Chapdelaine, DG Cerri, JC Dominique, SP Quenneville, D Skuk, JN

Kornegay, JC Bizario, X Xiao, JP Tremblay: Expression of dog microdystrophin in mouse and dog muscles by gene therapy. Mol Ther 18:1002-9, 2010. doi: 10.1038/mt.2010.23.

86. Marsh AP, JD Eggebeen, JN Kornegay, CD Markert, MK Childers. Kinematics of gait

in golden retriever muscular dystrophy. Neuromuscul Disord 20:16-20, 2010. doi: 10.1016/j.nmd.2009.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 85. Qiao C, J Li, H Zheng, J Bogan, J Li, Z Yuan, C Zhang, D Bogan, J Kornegay, X Xiao:

Hydrodynamic limb vein injection of AAV8 canine myostatin propeptide gene in normal dogs enhances muscle growth. Hum Gene Ther 20:1-10, 2009. doi: 10.1089/hum.2008.135.

84. Yue Y, A Ghosh, C Long, B Bostick, BF Smith, JN Kornegay, D Duan: A single

intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs. Mol Ther 16:944-52, 2008. doi: 10.1038/mt.2008.207.

83. Wang B, J Li, C Qiao, C Chen, P Hu, X Zhu, L Zhou, J Bogan, J Kornegay, X Xiao: A

canine minidystrophin is functional and therapeutic in mdx mice. Gene Ther 15:1099-106, 2008. doi: 10.1038/gt.2008.70.

82. Hanft LM, DJ Bogan, U Mayer, SJ Kaufman, JN Kornegay, JM Ervasti: Cytoplasmic γ-

actin expression in diverse animal models of muscular dystrophy. Neuromuscul Disord 17:569-74, 2007.

81. Brumitt JW, SC Essman, JN Kornegay, JP Graham, WJ Weber, CR Berry: Radiographic

features of Golden Retriever muscular dystrophy. Vet Radiol Ultrasound 47:574-80, 2006.

80. Gordon PN, JN Kornegay, JC Lattimer, CR Cook, T Tucker-Warhover: Use of a rivet-

like titanium clamp closure system to replace an external frontal bone flap after transfrontal craniotomy in a dog. J Am Vet Med Assoc 226:752-5, 2005.

79. Childers MK, JN Kornegay, KS McDonald: Skinned single fibers from normal and

dystrophin-deficient dogs incur comparable stretch-induced force deficits. Muscle Nerve 31:768-71, 2005.

78. Liu JMK, CS Okamura, DJ Bogan, JR Bogan, MK Childers, JN Kornegay: Effects of

prednisone in canine muscular dystrophy. Muscle Nerve 30:767-73, 2004. 77. Dell’Agnola C, Z Want, R Storb, SJ Tapscott, CS Kuhr, SD Hauschka, RS Lee, GE Sale,

E Zellmer, S Gisburne, J Bogan, JN Kornegay, BJ Cooper, TA Gooley, M-T Little: Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood 104:4311-8, 2004.

76. Shimatsu Y, K Katagiri, T Furuta, M Nakura, Y Tanioka, K Yuasa, M Tomohiro, JN

Kornegay, I Nonaka, S Takeda: Canine X-linked muscular dystrophy in Japan (CXMDJ). Exp Anim 52:93-7, 2003.

75. Schatzberg SJ, NJ Haley, SC Barr, C Parrish, S Steingold, BA Summers, A deLahunta,

JN Kornegay, NJ Sharp: Polymerase chain reaction (PCR) amplification of parvoviral DNA from the brains of dogs and cats with cerebellar hypoplasia. J Vet Intern Med 17:538-44, 2003.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 74. Kornegay JN, DD Cundiff, DJ Bogan, JR Bogan, CS Okamura: The cranial sartorius

muscle undergoes true hypertrophy in dogs with golden retriever muscular dystrophy. Neuromuscul Disord 13:493-500, 2003.

73. Childers MK, CS Okamura, DJ Bogan, JR Bogan, GF Petroski, K McDonald, JN

Kornegay: Eccentric contraction injury in dystrophic canine muscle. Arch Phys Med Rehabil 83:1572-8, 2002.

72. Childers MK, CS Okamura, DJ Bogan, JR Bogan, MJ Sullivan, JN Kornegay: Myofiber

injury and regeneration in a canine homologue of Duchenne muscular dystrophy. Am J Phys Med Rehab 80:175-81, 2001.

71. Bartlett RJ, S Stockinger, MM Denis, WT Bartlett, L Inverardi, TT Le, NT Man, GE

Morris, DJ Bogan, J Metcalf-Bogan, JN Kornegay: In vivo targeted repair of a point mutation in the canine dystrophin gene by a RNA/DNA oligonucleotide. Nature Biotech 18:615-22, 2000.

70. Schatzberg SJ, NJ Olby, M Breen, LVB Anderson, CF Langford, HF Dickens, SD

Wilton, CJ Zeiss, MM Binns, JN Kornegay, GE Morris, NJH Sharp: Molecular analysis of a spontaneous dystrophin “knockout” dog. Neuromuscul Disord 9:289-95, 1999.

69. Thrall DE, SM LaRue, BE Powers, RL Page, J Johnson, SL George, JN Kornegay, MC

McEntee, DC Levesque, BC Case, MW Dewhirst, EL Gillette: Use of whole body hyperthermia as a method to heat inaccessible tumors uniformly: A Phase III trial in canine brain masses. Int J Hyperthermia 15:383-98, 1999.

68. Sharp NJ, BJ Davis, JS Guy, JM Cullen, SF Steingold, JN Kornegay: Hydranencephaly

and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection. J Comp Pathol 121:39-53, 1999.

67. Kornegay JN, DJ Bogan, JR Bogan, MK Childers, DD Cundiff, GF Petroski, RO

Schueler: Contraction force generated by tarsal joint flexion and extension in dogs with golden retriever muscular dystrophy. J Neurol Sci 166:115-21, 1999.

66. Hardie EM, O Ramirez III, EM Clary, JN Kornegay, MT Correa, RA Feimster, ER

Robertson: Abnormalities of the thoracic bellows: Stress fractures of the ribs and hiatal hernia. J Vet Int Med 12:279-87, 1998.

65. Higgins RJ, RA LeCouteur, JN Kornegay, JR Coates: Late-onset progressive

spinocerebellar degeneration in Brittany Spaniel dogs. Acta Neuropathol (Berl) 96:97-101, 1998.

64. Schatzberg SJ, SD Wilton, LVB Anderson, JN Kornegay, NJH Sharp: Alternate

dystrophin gene transcripts in golden retriever muscular dystrophy. Muscle Nerve 21:991-8, 1998.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 63. Childers MK, JN Kornegay, R Aoki, L Otaviani, DJ Bogan, G Petroski: Evaluating

motor endplate-targeted injections of botulinum toxin type A in a canine model. Muscle Nerve 21:653-5, 1998.

62. Rewerts JM, AM Grooters, JT Payne, JN Kornegay: Atraumatic rupture of the

gastrocnemius muscle in a dog after corticosteroid administration. J Am Vet Med Assoc 210:655-7, 1997.

61. Thomas WB, Sorjonen DC, Scheuler RO, JN Kornegay: Magnetic resonance imaging

of brain infarction in seven dogs. Vet Radiol Ultrasound 37:345-50, 1996. 60. Cauzinille L, JN Kornegay: Fibrocartilaginous embolism of the spinal cord in dogs:

Review of 36 histologically confirmed cases and retrospective study of 26 suspected cases. J Vet Int Med 10:241-5, 1996.

59. Bartlett RJ, NJ Winand, SL Secore, JT Singer, S Fletcher, S Wilton, DJ Bogan, JR

Metcalf-Bogan, WT Bartlett, JM Howell, BJ Cooper, JN Kornegay: Mutation segregation and rapid carrier detection of X-linked muscular dystrophy in dogs. Am J Vet Res 57:650-4, 1996.

58. Thomas WB, SJ Wheeler, R Kramer, JN Kornegay: Magnetic resonance imaging

features of primary brain tumors in dogs. Vet Radiol Ultrasound 37:20-7, 1996. 57. Siegel S, JN Kornegay, Thrall DE: Postoperative irradiation of spinal cord tumors in 9

dogs. Vet Radiol Ultrasound 37:150-3, 1996. 56. Bagley RS, JN Kornegay, SB Lane, DL Thrall, RL Page: Cystic meningiomas in two

dogs. J Vet Int Med 10:72-5, 1996. 55. Kornegay JN, NJH Sharp: A method to measure contraction tension sequentially from

the peroneus longus muscle of dogs. Acta Cardiomiol 7:15-24, 1995. 54. Hudson LC, L Cauzinille, JN Kornegay, MB Tompkins: Magnetic resonance imaging

of the normal feline brain. Vet Radiol Ultrasound 36:267-75, 1995. 53. Hadrick MK, SE Bunch, JN Kornegay: Ivermectin toxicosis in two Australian

shepherds. J Am Vet Med Assoc 206:1147-50, 1995. 52. Thomas WB, RO Schueler, JN Kornegay: Surgical excision of a cerebral arteriovenous

malformation in a dog. Prog Vet Neurol 6:20-3, 1995. 51. Neer TM, JN Kornegay: Leucoencephalomalacia and cerebral white matter vacuolar

degeneration in two related Labrador retriever puppies. J Vet Int Med 9:100-4, 1995.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 50. Guenego L, L Cauzinille, A McVey, W Thomas, J Kornegay: Syringomyélie associée à

un kyste arachnoidien cervical chez un labrador. Prat Méd Chir Anim Comp 29:481-5, 1994.

49. Ervasti JM, SL Roberds, RD Anderson, NJH Sharp, JN Kornegay, KP Campbell:

Alpha-dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy. FEBS Lett 350:173-6, 1994.

48. Prattis SM, SB Horton, SD Van Camp, JN Kornegay: Immunohistochemical detection

of neural cell adhesion molecule and laminin in X-linked dystrophic dogs and mdx mice. J Comp Pathol 110:253-66, 1994.

47. Kornegay JN, NJH Sharp, RO Schueler, CW Betts: Tarsal joint contracture in dogs with

golden retriever muscular dystrophy. Lab Anim Sci 44:331-3, 1994. 46. Lane SB, JN Kornegay, JE Oliver, Jr, JR Duncan: Feline spinal lymphosarcoma: A

retrospective evaluation of 24 cases. J Vet Int Med 8:99-104, 1994. 45. Gorospe JRM, MD Tharp, J Hinckley, JN Kornegay, Hoffman EP: A role for mast cells

in the progression of Duchenne muscular dystrophy? Correlations in dystrophin-deficient humans, dogs, and mice. J Neurol Sci 122:44-56, 1994.

44. Kornegay JN, Sharp NJH, Bogan DJ, Van Camp SD, Metcalf JR, Schueler RO:

Contraction tension and kinetics of the peroneus longus muscle in golden retriever muscular dystrophy. J Neurol Sci 123:100-7, 1994.

43. Bagley RS, JN Kornegay, SJ Wheeler, SB Plummer, L Cauzinille: Generalized tremors

in Maltese terriers: Clinical findings in 7 cases. J Am Anim Hosp Assoc 29:141-5, 1993. 42. Sharp NJH, JN Kornegay, RJ Bartlett, W-Y Hung, MJ Dykstra: A canine model of

notexin-induced muscle injury. J Neurol Sci 116:73-81, 1993. 41. Hopkins AL, JF Howard, SJ Wheeler, JN Kornegay: Stimulated single fibre

electromyography in normal dogs. J Sm Anim Pract 34:271-6, 1993. 40. Anderson JE, BA Kakulas, PF Jacobsen, RD Johnsen, JN Kornegay, MD Grounds:

Comparison of basic fibroblast growth factor in X-linked dystrophin-deficient myopathies of human, dog, and mouse. Growth Factors 9:107-21, 1993.

39. Plummer SB, SE Bunch, LA Khoo, KA Spaulding, JN Kornegay: Tethered spinal cord

and intradural lipoma associated with meningocele in a Manx-cross cat. J Am Vet Med Assoc 203:1159-61, 1993.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 38. Prattis SM, DH Gebhart, G Dickson, DJ Watt, JN Kornegay: Magnetic affinity cell

sorting (MACS) separation and flow cytometric characterization of neural cell adhesion molecule (NCAM) - positive, cultured myogenic cells from normal and dystrophic dogs. Exp Cell Res 208:453-64, 1993.

37. Bagley RS, JD Stefanacci, B Hansen, JN Kornegay: Dysphonia in two dogs with cranial

cervical intervertebral disk extrusion. J Am Anim Hosp Assoc 29:557-9, 1993. 36. Bagley RS, LJ Forrest, L Cauzinille, AL Hopkins, JN Kornegay: Cervical vertebral

fusion and concurrent intervertebral disc extrusion in four dogs. Vet Radiol Ultrasound 34:336-9, 1993

35. Thomson CE, JN Kornegay, RA Burn, BP Drayer, DM Hadley, DC Levesque, LA

Gainsburg, SB Lane, NJH Sharp, SJ Wheeler: Magnetic resonance imaging - A general overview of principles and examples in veterinary neurodiagnosis. J Vet Radiol Ultrasound 34:2-17, 1993.

34. Valentine BA, NJ Winand , D Pradhan, NS Moise, A de Lahunta, JN Kornegay, BJ

Cooper: Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy. Am J Med Gen 42:352-6, 1992.

33. Sharp NJH, JN Kornegay, SD Van Camp, MH Herbstreith, SL Secore, S Kettle, W-Y

Hung, CD Constantinou, MJ Dykstra, AD Roses, RJ Bartlett: An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy. Genomics 13:115-21, 1992.

32. Cauzinille L, JN Kornegay: A case of acquired syringomyelia in a dog. J Am Vet Med

Assoc 201:1225-8, 1992. 31. Breitschwerdt EB, JN Kornegay, SJ Wheeler, JB Stevens, CJ Baty: Episodic weakness

associated with exertional lactic acidosis and myopathy in old English sheepdog littermates. J Am Vet Med Assoc 201:731-6, 1992.

30. Plummer SB, SJ Wheeler, DE Thrall, JN Kornegay: Computed tomography of primary

inflammatory brain disorders in dogs and cats. J Vet Radiol Ultrasound 33:307-12, 1992. 29. Heidner GL, JN Kornegay, RL Page, DE Thrall: A retrospective study of 86 dogs with

brain tumors. Identification of prognostic variables and response to treatment. J Vet Int Med 5:219-226, 1991.

28. Thomson CE, JN Kornegay, JB Stevens: Analysis of cerebrospinal fluid from the

cerebellomedullary and lumbar cisterns of dogs with focal neurologic disease: 145 cases (1985-1987). J Am Vet Med Assoc 196:1841-4, 1990.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 27. Jans HE, JN Kornegay, EB Breitschwerdt, PJ Armstrong: Peroneal and tibial

neuropathy in Walker hound puppies: a kennel epizootic. J Am Vet Med Assoc 197:498-500, 1990.

26. Davidson M, M Nasisse, J Kornegay: Intermediate filament complement of the normal

and gliotic canine retina. J Comp Pathol 103:125-134, 1990. 25. Hardie EM, JN Kornegay, JM Cullen: Successful treatment of status epilepticus

following operation for portosystemic shunt. Vet Surg 19:412-417, 1990. 24. Thomson CE, JN Kornegay, JB Stevens: Canine intervertebral disk disease: Changes in

the cerebrospinal fluid. J Sm Anim Pract 30:685-8, 1989. 23. Valentine BA, JN Kornegay, BJ Cooper: Clinical electromyographic studies of canine

X-linked muscular dystrophy. Am J Vet Res 50:2145-7, 1989. 22. Kornegay JN, EJ Gorgacz: Marek's disease herpesvirus induced transient paralysis:

Electron microscopic lesions. Acta Neuropathol (Berl) 75:597-604, 1988. 21. Kornegay JN, SM Tuler, DM Miller, DC Levesque: Muscular dystrophy in a litter of

golden retriever dogs. Muscle Nerve 11:1056-64, 1988. 20. Cooper BJ, NJ Winand, H Stedman, BA Valentine, EP Hoffman, LM Kunkel, M-O Scott,

KH Fischbeck, JN Kornegay, RJ Avery, JR Williams, RD Schmickel, JE Sylvester: The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs. Nature 334:154-6, 1988.

19. Kornegay JN, MA Goodwin, LK Spiridakis: Hypomyelination in Weimaraner dogs.

Acta Neuropathol (Berl) 72:394-401, 1987. 18. Thrall DE, RL Page, MW Dewhirst, RE Meyer, PJ Hoopes, JN Kornegay: Temperature

measurements in normal and tumor tissue of dogs undergoing whole body hyperthermia. Cancer Res 46:6229-35, 1986.

17. Kornegay JN: Cerebellar vermian hypoplasia in dogs. Vet Pathol 23:374-9, 1986. 16. Kornegay JN, JE Oliver, EJ Gorgacz: Clinicopathologic features of brain herniation in

animals. J Am Vet Med Assoc 182:1111-6, 1983. 15. Kornegay JN, EJ Gorgacz, MA Parker, LW Schierman: Motor nerve conduction

velocity in normal chickens. Am J Vet Res 44:1537-40, 1983. 14. Kornegay JN, EJ Gorgacz, MA Parker, J Brown, LW Schierman: Marek's disease

herpesvirus induced transient paralysis: Clinical and electrophysiologic findings in resistant and susceptible lines of chickens. Am J Vet Res 44:1541-4, 1983.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 13. Kornegay JN, EJ Gorgacz, MA Parker, JR Duncan, LW Schierman: Marek's disease

herpesvirus induced transient paralysis: A comparison of lesions in susceptible and resistant lines of chickens. Acta Neuropathol (Berl) 6l:263-9, 1983.

12. Purinton PT, JE Oliver Jr, JN Kornegay, WE Bradley: Cortical averaged evoked

potentials produced by pudendal nerve stimulation in dogs. Am J Vet Res 44:446-8, 1983.

11. Aron DN, JN Kornegay: The clinical significance of traumatic lung cysts and associated

pulmonary abnormalities in the dog and cat. J Am Anim Hosp Assoc 19:903-12, 1983. 10. Chambers JN, JE Oliver, JN Kornegay, GA Malnati: Ventral decompression for caudal

cervical disk herniation in large- and giant-breed dogs. J Am Vet Med Assoc 180:410-4, 1982.

9. Kornegay JN, EJ Gorgacz: Intracranial epidermoid cysts in three dogs. Vet Pathol

19:646-50, 1982. 8. Kornegay JN, AE Marshall, PT Purinton, JE Oliver: Somatosensory evoked potential in

normal dogs. Am J Vet Res 42:70-3, 1981. 7. Kornegay JN, DL Barber: Diskospondylitis in dogs. J Am Vet Med Assoc 177:337-41,

1980. 6. Kornegay JN, EJ Gorgacz, DL Dawe, JM Bowen, NA White, EV DeBuysscher:

Polymyositis in dogs. J Am Vet Med Assoc 197:431-8, 1980. 5. Kornegay JN, CE Greene, C Martin, EJ Gorgacz, DK Melcon: Idiopathic hypocalcemia

in four dogs. J Am Anim Hosp Assoc 16:723-34, 1980. 4. Kornegay JN, DL Barber, TD Earley: Cranial thoracic diskospondylitis in two dogs. J

Am Vet Med Assoc 174:192-4, 1979. 3. Kornegay JN: Feline infectious peritonitis: The central nervous system form. J Am

Anim Hosp Assoc 14:580-4, 1978. 2. Kornegay JN, MD Lorenz, RD Zenoble: Bacterial meningoencephalitis in two dogs. J

Am Vet Med Assoc 173:1334-6, 1978. 1. Vandevelde M, KG Braund, TL Walker, JN Kornegay: Dysmyelination of the central

nervous system in the chow-chow dog. Acta Neuropathol (Berl) 42:211-5, 1978.

Curriculum Vitae Joe N. Kornegay, DVM, PhD Research Abstracts 86. Morales L, Y Song, A Malik, M Petrov, ME Choi, MA Mitchell, TS Khurana, JN

Kornegay, HH Stedman. Utrophin vector protected by central tolerance as potential cure for muscular dystrophy. Mol Ther 27:23, 2019.

85. Fickau B, M Beatka, P Gonzales, H Meng, S Birch, CA Morris, S Ayres, J Tinklenberg,

M Vanden Avond, J Kornegay, JS Schneider, KJ Brown, MW Lawlor: Complementary techniques to evaluate microdystrophin expression in Duchenne muscular dystrophy gene therapy studies. Mol Ther 26:396-7, 2018.

84. S Mata Lopez, C Balog, S Vitha, M Bettis, H Barnett, J Kornegay, P Nghiem: DMD

Clinical Therapies II: P130. Cas9 and TALEN edit the DMD genetic mutation in golden retriever muscular dystrophy. Neuromuscul Disord 28:S68, 2018.

83. Crudele JM, SM Birch, CH Hakim, D Golebiowski, C Shanks, JS Morris, JS Schneider,

SD Hauschka, D Duan, JN Kornegay, JS Chamberlain: Assessing anti-dystrophin T-cell responses by Elispot following AAV9-microdystrophin gene therapy in dogs. Mol Ther 26:104, 2018.

82. Birch SM, MW Lawlor, LJ Guo, JM Crudele, EC Hawkins, PP Nghiem, MA Styner, MJ

Struharik, KJ Brown, D Golebiowski, JP Gonzalez, CA Morris, JS Schneider, JS Chamberlain, BJ Byrne, JN Kornegay. A blinded, placebo-controlled systemic gene therapy efficacy study in the GRMD model of Duchenne muscular dystrophy. Mol Ther 25:193, 2017.

81. Song Y, L Morales, C Greer, A Mead, A Malik, M Mitchell, M Petrov, X Lu, D

VanBelzen, M Joffe, M Choi, L Su, J Kornegay, T Khurana, HH Stedman: AAV9-utrophin prevents myonecrosis in dystrophic mice and dogs. Mol Ther 25:146, 2017.

80. Mead AF, Y Song, C Greer, A Malik, L Morales, M Petrov, T Khurana, JN Kornegay,

HH Stedman: Comparative phylogenomics of the dystrophin/utrophin supergene family yields improved transgenes for gene therapy in DMD. Mol Ther 25:202, 2017.

79. Song Y, A Malik, A Mead, M Mitchell, M Petrov, X Lu, D VanBelzen, M Joffe, M Choi,

L Su, J Kornegay, T Khurana, H Stedman: AAV9-utrophin prevents myonecrosis in dystrophic mice and dogs without immunosuppression. Mol Ther 24:S37, 2016.

78. VanBelzen DJ, A Malik, J Kornegay, HH Stedman: Concerted evolution of pseudogenes

facilitated contiguous deletion of the canine dystrophin and TMEM47 genes by homologous recombination. Mol Ther 24:S48-49, 2016.

77. Kozyak BW, A Mead, Y Song, L Morales, J Kornegay, HH Stedman: Clinico-

Pathological correlation in the earliest stages of muscular dystrophy suggests sensitive physiological parameters as novel primary endpoints for systemic gene therapy. Mol Ther 24:S153, 2016.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 76. Song Y, A Mead, M Petrov, P Ingraham, L Morales, S Rosenblum, J Kornegay, HH

Stedman: Hypersensitivity of MYH16 fibers (M Fibers) to myodegeneration in canine muscular dystrophy. Mol Ther 24:154, 2016.

75. Li J, J Kornegay, C Qiao, H Zheng, J Li, R Tang, Y Dai, X Xiao: Long-term (2-8 years)

body-wide expression of AAV9-minidystrophin gene in golden retriever muscular dystrophy dogs after regional limb vein injection. Mol Ther 24:S284, 2016.

74. Song Y, A Malik, AF Mead, M Mitchell, M Petrov, L Su, L Morales, S Rosenblum, T

Khurana, JN Kornegay, HH Stedman: Prevention of muscular dystrophy by an AAV vector encoding a nonimmunogenic protein based on the evolution of utrophin and dystrophin. Mol Ther 24:S286, 2016.

73. Y Echigoya, N Trieu, K Hosoki, W Duddy, T Partridge, E Hoffman, J Kornegay, C

Rogers, T Yokota: Dystrophin exon 52-deleted pigs as a new animal model of Duchenne muscular dystrophy: Its characterization and potential as a tool for developing exon skipping therapy. Mol Ther 24:S247, 2016.

72. J Soslow, CL Galindo, H Smith, BM Damon, JN Kornegay, WB Burnette, D Sawyer, L

Meacham: Osteopontin and brain derived neurotrophic factor: Biomarkers of cardiovascular disease in Duchenne muscular dystrophy. J Am Coll Cardiol 67 (13_S), 1510, 2016.

71. Galindo C, C Brinkmeyer-Langford, M Gupte, H Smith, J Soslow, D Sawyer, J

Kornegay, L Markham: GRMD gene expression in skeletal and cardiac muscle: Insights into molecular pathways of progression and therapeutic implications for DMD Cardiomyopathy. FASEB J 29 (1 Suppl), 1038.13, 2015.

70. Birch S, R Lunde, M Lenox, J Griffin, J Kornegay, C Goodlett, TA Cudd, S Washburn

MRI derived volumetric brain measurements in the ovine. Alcoholism-Clinical and Experimental Research. 38:34A, Wiley-Blackwell, 2015.

69. Malik A, A Mead, M Petrov, D VanBelzen, Y Song, X Lu, M Choi, J Kornegay, H

Stedman: Systemic gene therapy for DMD-advanced preclinical/translational studies to minimize risk and maximize potential benefit for patients with dystrophin gene deletions. Mol Ther 22: S236-7, 2014.

68. Malik A, A Mead, M Petrov, M Mitchell, L Su, F Balzer, J Farag, J Bogan, D Bogan, J

Kornegay, H Stedman: Safety and histological signs of efficacy following systemic AAV9-CMV-microutrophin gene therapy in a canine model for Duchenne muscular dystrophy. Mol Ther 21:S38, 2013.

67. DeVanna JC, JN Kornegay, DJ Bogan, JR Bogan, JL Dow, EC Hawkins: Assessment of

respiratory dysfunction in dogs with golden retriever muscular dystrophy: Arterial blood gas analysis and tidal breathing spirometry. J Vet Int Med 27:751-2, 2013.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 66. RK Bhavaraju-Sanka RK, JN Kornegay, JR Bogan, JL Dow, J Howard: Single fiber

electromyography in the golden retriever muscular dystrophy model. Clin Neurophysiol 123:e35, 2012.

65. Bhavaraju-Sanka RK, JN Kornegay, JR Bogan JL Dow, J Howard: Electrophysiological

abnormalities of the golden retriever muscular dystrophy model. Clin Neurophysiol123:e35, 2012.

64. Li J, C Qiao, J Bogan, J Li, R Tang, D Bogan, J Dow, ZJ Fan, WJ Powers, RJ Samulski,

J Kornegay, X Xiao: Efficient hydrodynamic limb perfusion of an AAV9 mini-dystrophin in adult GRMD dogs by a clinically used, pressure-and speed-controlled pump. Mol Ther 20:S42, 2012.

63. Li J, C Qiao, D Bogan, R Tang, J Bogan, T Bian, J Li, J Dow, Z Yuan, JC Grieger, RJ

Samulski, J Kornegay, X Xiao: Muscle force improvement by long-term systemic expression of an AAV9 minidystrophin after delivery in young adult GRMD dogs without immune suppression. Mol Ther 20:S69, 2012.

62. Cotten SW, KM Wadosky, D Bogan, JN Kornegay, MS Willis: Regulation of the

calpain and ubiquitin proteasome system in a canine model of muscular dystrophy with myostatin inhibition. FASEB J 26 (1 Suppl), 478.3, 2012.

61. Mead A, A Malik, M Petrov, M Childers, J Bogan, G Seidner, J Kornegay, H Stedman:

Functional decline, remodeling, and compensation in the respiratory system of a canine model of Duchenne muscular dystrophy. FASEB J 26 (1 Suppl), 1078.4, 2012.

60. Li J, C Qiao, J Bogan, D Bogan, R Tang JB Li, C Chen, H Zheng, J Dow, JN Kornegay,

X Xiao: Efficient long-term bodywide expression of an AAV9-minidystrophin in the muscle and heart of young adult GRMD dogs after intravascular injection without immune suppression. Mol Ther 19 (Suppl):S21, 2011.

59. Bhavaraju-Sanka RK, JN Kornegay, JR Bogan, JL Dow, J Howard Electrophysiological

abnormalities of the golden retriever muscular dystrophy model. Muscle Nerve 44:644, 2011.

58. Wadosky KM, JE Rodriguez, L Li, D Bogan, JN Kornegay, MS Willis: Regulation of

the ubiquitin proteasome and calpain systems in a dog model of duchenne muscular dystrophy. FASEB J 25, 1000.8, 2011.

57. Townsend DW, I Turner, S Yasuda, J Martindale, MS Shillingford, JN Kornegay, JM

Metzger: Prevention of cardiac injury and ventricular remodeling in dystrophic dogs by chronic administration of membrane sealant P188. Circulation 120 (Suppl 18), S720-1, 2011.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 56. Scola MR, JN Kornegay, CM Gallippi. Delineating serial mechanical property changes

in a dog model of duchenne muscular dystrophy using ARFI ultrasound, in vivo. IEEE International Ultrasonics Symposium 1360-3, 2010.

55. Petrov M, M Mitchell, A Malik, A Mead, F Balzer, L Su, J Farag, B Kozyak, K Gopal, C

Bridges, J Bogan, M Childers, J Kornegay, H Stedman: First generation AAV-microutrophin vector infused into the isolated pelvic limb of a canine model for Duchenne muscular dystrophy. Mol Ther 18 (Suppl 1):S176, 2010.

54. Mead A, A Malik, M Petrov, M Childers, J Bogan, J Kornegay, H Stedman: External,

non-invasive monitoring of progressive cardiorespiratory dysfunction in a canine model of DMD. Mol Ther 18 (Suppl 1):S177-8, 2010.

53. Malik A, A Xu, J Chen, A Mead, M Childers, J Bogan, S Schatzberg, J Kornegay, H

Stedman: Detailed physical mapping of deletion breakpoints in the GSHP dog model for DMD. Mol Ther 18 (Suppl 1):S180, 2010.

52. Mead AF, A Malik, M Petrov, M Childers, M Mitchell, J Bogan, J Kornegay, B

Nickens, H Stedman H: High force myosin correlated with the early degeneration of jaw closing muscle in the GRMD model of DMD. Mol Ther 18 (Suppl 1):S305, 2010.

51. Flanigan KM, A Larsen, L Taylor, J Bogan, D Bogan, J Kornegay. Characterization of

DMD mutations in novel dog models of dystrophinopathy. Neurology 72:A307, 2009. 50. Scola MR, Behler RH, JN Kornegay, CM Gallippi: In vivo ARFI imaging of the

mechanical properties of muscle in a dog model of Duchenne muscular dystrophy. Ultrasonics Symposium (IUS) IEEE International, 1871-4, 2009.

49. Cheng CP, HJ Cheng, P Zhou, CD Markert, M Cross, JN Kornegay, H Stedman, MK

Childers: Cardiomyopathy in a canine model of Duchenne muscular dystrophy: effects of left ventricle and myocyte systolic and diastolic functional performance, L-type calcium current response and beta-adrenergic modulation. Circulation 120 (Suppl 2): S667, 2009.

48. Li J, J Bogan, C Chen, D Bogan, B Wang, Z Yuan, C Qiao, JN Kornegay, X Xiao:

Hydrodynamic limb vein injection of AAV9 results in regional and systemic long-term expression of minidystrophin in young adult GRMD dogs. Mol Ther 17 (S1):S278, 2009.

47. Pichavant C, P Chapdelaine, JN Kornegay, JCS Bizario, X Xiao, JP Tremblay:

Expression of dog micro-dystrophin in mouse and dog muscles following the transplantation of muscle precursor cells genetically modified with a lentiviral vector or with the introduction of plasmid by electrotransfer. Mol Ther 17 (S1):S133, 2009.

46. Kornegay JN, J Li, JR Bogan, DJ Bogan, C Chen, C Qiao, JR Howard, Jr, X Xiao:

Widespread muscle expression of an AAV-9 human mini-dystrophin construct after systemic intravenous administration in golden retriever muscular dystrophy (GRMD) neonatal dogs. Mol Ther 17 (S1):S152-3, 2009.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 45. Malik A, A Mead, M Petrov, M Childers, J Bogan, J Kornegay, H Stedman: External,

non-invasive monitoring of progressive respiratory mechanical dysfunction in a canine model of Duchenne muscular dystrophy. Making Muscle in the Embryo and Adult: A joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells. Columbia University, New York, NY, 2009.

44. Mead A, A Malik, M Petrov, M Childers, M Mitchell, J Bogan, J Kornegay, H Stedman

H: High force myosin correlated with the early degeneration of jaw closing muscles in the golden retriever muscular dystrophy (GRMD) model of Duchenne muscular dystrophy (DMD). Making Muscle in the Embryo and Adult: A joint meeting of Frontiers in Myogenesis and Skeletal Muscle Satellite and Stem Cells. Columbia University, New York, NY, 2009.

43. Kellman P, D Hernando, S Shah, RF Hoyt, RM Kotin, BW Keene, JN Kornegay, AH

Aletras, AE Arai: Myocardial fibro-fatty infiltration in Duchenne muscular dystrophy canine model detected using multi-echo Dixon method of water and fat separation imaging. Proc Intl Soc Mag Reson Med 17:3762, 2009.

42. Qiao C, J Bogan, J Li. Z Hui, Z Yuan, J Li, D Bogan, J Kornegay, X Xiao: Myostatin

propeptide gene delivery in normal dogs via AAV vector increased muscle fiber size. Mol Ther 16 (S1):S376, 2008.

41. Kornegay J, C Chen, J Li, J Bogan, D Bogan, J Chen, B Wang, T Zhou, RJ Samulski, X

Xiao: Long-term mini-dystrophin expression without immunosuppression in GRMD dogs after AAV8-mediated gene delivery by hydrodynamic limb vein injection. Mol Ther 16 (S1):S374, 2008.

40. Yue Y, A Ghosh, C Long, B Bostick, BF Smith, JN Kornegay, D Duan: Systemic AAV-

9 delivery in normal dog leads to high-level persistent transduction in whole body skeletal muscle. Mol Ther 16 (S1):S374, 2008.

39. Kornegay JN, DJ Bogan, JR Bogan: Functional correlation in golden retriever muscular

dystrophy. Mol Ther 16 (S1):S200, 2008. 38. Kornegay JN, DJ Bogan, JR Bogan: Effect of gender on phenotype in golden retriever

muscular dystrophy. Mol Ther 16 (S1):S200-1, 2008. 37. Yue Y, J Bogan, A Ghosh, D Bogan, C Long, BF Smith, JN Kornegay, D Duan:

Intravascular delivery of AAV-9 leads to efficient transduction of multiple muscles in dog. Mol Ther 15 (S1):S276, 2007.

36. Smith BF, JN Kornegay, D Duan: Independent canine models of Duchenne muscular

dystrophy due to intronic insertions of repetitive DNA. Mol Ther 15 (Suppl 1):S51, 2007.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 35. Balzer FJ, MK Childers, JR Bogan, DJ Bogan, JN Kornegay, HH Stedman: Non-

invasive measurement of maximal strength in the normal and dystrophic dog quadriceps using magnetic stimulation of the femoral nerve. Mol Ther 13 (Suppl 1):S223, 2006.

34. Smith BF, JN Kornegay: A pseudo-exon derived from an intronic insertion is

responsible for Duchenne-like muscular dystrophy in the Welsh corgi dog. Mol Ther 13 (Suppl 1):S215, 2006.

33. Wang B, J Li, L Zhou, C Qiao, M Tian, T Zhu, J Bogan, J Kornegay, X Xiao; Canine

mini-dystrophin gene transfer by AAV1 in mdx mice ameliorates dystrophic pathology and protects membrane integrity. Mol Ther 11 (Suppl 1):S308, 2005.

32. Childers M, J Liu, C Okamura, J Bogan, D Bogan, J Kornegay, K McDonald: Stretch

induced myofiber injury in a canine orthologue of Duchenne muscular dystrophy. J Neurol Sci 199 (Suppl 1):S25, 2002.

31. Childers MK, DJ Bogan, KS McDonald, MJ Rovetto, CS Okamura, JN Kornegay:

Length-force relationship in dystrophic canine hindlimb muscles. Arch Phys Med Rehabil 80:1152, 1999.

30. Childers MK, DJ Bogan, KS McDonald, MMJ Rovetto, CS Okamura, JN Kornegay:

Flexor muscles in a canine homologue of Duchenne muscular dystrophy are preferentially injured during experimental eccentric contractions. Arch Phys Med Rehabil 80:1152, 1999.

29. Okamura CS, DJ Bogan, MK Childers, JR Bogan, JN Kornegay: Muscle hypertrophy

and fiber type change in a canine model of Duchenne muscular dystrophy. Proc 39th Midwest Devel Biol Meeting 39:26, 1999.

28. Childers MK, DJ Bogan, CS Okamura, JR Bogan, MJ Sullivan, JN Kornegay: Do early

markers of myofiber injury and regeneration predict subsequent phenotype in golden retriever muscular dystrophy? Proc 39th Midwest Devel Biol Meeting, 39:18, 1999.

27. Okamura C, J Liu, D Bogan, J Bogan, M Childers, J Kornegay: Cellular effects of

prednisone therapy in canine dystrophy. J Neurol Sci 199 (Suppl 1):S10, 2002. 26. Childers MK, CS Okamura, MJ Sullivan, DJ Bogan, JR Bogan, JN Kornegay: Cranial

sartorius myofibers of the neonatal GRMD dog are preferentially permeable to Evans blue dye. Muscle Nerve (Suppl 7):S88, 1998.

25. Kornegay JN, DJ Bogan JR Bogan, DD Cundiff, CS Okamura, MK Childers:

Phenotypic variation in dogs with golden retriever muscular dystrophy (GRMD). Muscle Nerve (Suppl 7):S88, 1998.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 24. Schatzberg S, L Anderson, S Wilton, J Kornegay, C Mann, G Solomon, N Sharp:

Overcoming the golden retriever muscular dystrophy (GRMD) frameshift mutation. Muscle Nerve (Suppl 7):S128, 1998.

23. Bartlett RJ, MM Denis, JM McCue-Weston, JN Kornegay, JM Bogan, DJ Bogan, L

Inverardi, C Ricordi: Towards targeting reversion of muscular dystrophy mutations in live animals. American Society of Human Genetics, Denver, 1998.

22. Horowitz SH, JN Kornegay: Electromyographic and clinicopathological correlations in

GRMD. Electroenceph Clin Neurophysiol 103:124, 1997. 21. Nakagaki K, DH Gebhard, DJ Bogan, JN Kornegay: A quantitative comparison of

NCAM-positive muscle cells from normal and dystrophic dogs. Muscle Nerve 17 (Suppl 1):S193, 1994.

20. Nakagaki K, DH Gebhard, DJ Bogan, JN Kornegay: Selection of canine myogenic cells

with panning. Muscle Nerve 17 (Suppl 1):S260, 1994. 19. Gonano EF, M Pelosi, F Fortunato, N Bresolin, E Daminani, G Scarlato, G Meissner, J

Kornegay, E Carafoli: Regulation of cell calcium in dystrophic dog muscles. Can J Neurol Sci 20 (Suppl 4): S159, 1993.

18. Kornegay JN, SM Prattis, DJ Bogan, MJ Dykstra, NJH Sharp, W-Y Hung, RJ Bartlett,

HS Alameddine: Myoblast transplantation in notexin injured canine muscle. J Neuropathol Exp Neurol 50:319, 1991.

17. Burt CT, MJ Danon, J Kornegay, NJH Sharp, L Kwock: Proton (H-1) and phosphorus

(31P) magnetic resonance spectroscopy in dystrophin-deficient canine muscular dystrophy. Ann Neurol 30:301, 1991.

16. Hopkins AL, JF Howard, CR Stewart, SJ Wheeler, JN Kornegay: Stimulated single

fiber electromyography in normal dogs. J Vet Int Med 5:136, 1991. 15. Prattis SM, D Gebhard, G Dickson, D Watt, JN Kornegay: NCAM expression in mdx

mice and GRMD dogs and separation of canine myogenic cells. J Cell Biol 115:3799, 1991.

14. Coleman MG, SM Prattis, JN Kornegay, GE Jones, TA Partridge, DJ Watt: Affinity

purification of myogenic cells for myoblast transfer. J Cell Biochem 15C (Suppl):36, 1991.

13. Hardie EM, JN Kornegay, JM Cullen: Successful treatment of status epilepticus

following operation for portosystemic shunt. Vet Surg 19:67, 1990. 12. Dykstra MJ, NJH Sharp, DJ Bogan, JN Kornegay: Notexin-induced muscle injury in

dogs. J Neurol Sci 98 (Suppl):127, 1990.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 11. Nakagaki K, JN Kornegay: Expression of galactocerebroside and A2B5-binding

ganglioside in developing chicken brain. Abstract presented at the XIth International Congress of Neuropathology, Kyoto, Japan, September, 1990.

10. Alameddine H, N Sharp, M Dehaupas, JN Kornegay, M Fardeau: Lymphocyte Leu-19

antigen expression in regenerating canine muscles. J Neurol Sci 98 (Suppl):296, 1990. 9. Bartlett RJ, NJH Sharp, SL Secore, HY Hung, JN Kornegay, AD Roses: The canine and

human DYS genes are highly conserved. J Neurol Sci 98 (Suppl):165, 1990. 8. Sharp NJH, JN Kornegay, AD Roses, IR Griffiths, RJ Bartlett: A canine model for

Duchenne muscular dystrophy. Neuropathol Appl Neurobiol 15:270, 1989. 7. Kornegay JN, NJH Sharp, RJ Bartlett, OE Okwari, E Coleman, AD Roses: Phenotypic

aspects of a canine model of Duchenne muscular dystrophy. Neurol 39 (Suppl 1):154, 1989.

6. Kornegay JN, MJ Dykstra, NJH Sharp, RJ Bartlett, SD Van Camp: Golden retriever

muscular dystrophy: Degree of fiber mineralization. Neurosci Let 36 (Suppl):588, 1989. 5. Jans HE, JN Kornegay, EB Breitschwerdt, PJ Armstrong: Peroneal and tibial

neuropathy in walker hound puppies. J Vet Int Med 3:137, 1989. 4. Kornegay JN, NJH Sharp, SD Van Camp, W Sussman, RJ Bartlett, AD Roses: Early

pathologic features of golden retriever muscular dystrophy: A model of Duchenne muscular dystrophy. J Neuropathol Exp Neurol 48:348, 1989.

3. Bartlett RJ, JN Kornegay, NJH Sharp, AD Roses: Golden retriever myopathy: An

animal model for Duchenne muscular dystrophy. Genome 30:443, 1988. 2. Drayer B, JN Kornegay, D Osborne, R Darwin, S Riederer: Paramagnetic Gd DTPA

enhancement of meningioma, metastasis, and leukoencephalitis. Am J Neuroradiol 6:474-5, 1985.

1. Parker M, JN Kornegay, E Gorgacz, L Schierman: Immunologic and neurologic factors

associated with herpesvirus-caused transient paralysis in fowl. Fed Proceed 41:697, 1982. Research Publications in Non-edited, Non-peer-reviewed Sources 11. MR Selzo, JN Kornegay, KA Spaulding, A Bettis, E Snook, M Styner, Jiahui Wang,

Caterina M Gallippi: VisR ultrasound evaluation of dystrophic muscle degeneration in a dog cross-section and comparison to histology and MRI. Ultrasonics Symposium (IUS), 2015 IEEE International, 1-4, 2015

10. Wang J, Z Fan, JN Kornegay, MA Styner: MRI-based quantification of Duchenne

muscular dystrophy in a canine model. Proc SPIE 7965:0G1-9, 2011.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 9. Bartlett RJ, NJH Sharp, JN Kornegay, AD Roses: Normal and abnormal dystrophin

gene expression. In Kakulas BA, Howell J Mc, Roses AD (eds). Duchenne Muscular Dystrophy. Animal Models and Genetic Manipulation. Raven Press, 1992, 41-66.

8. Kornegay JN: Golden retriever muscular dystrophy: The model and relevance to

developmental therapeutics. In Kakulas BA, Howell J Mc, Roses AD (eds). Duchenne Muscular Dystrophy. Animal Models and Genetic Manipulation. Raven Press, 1992, 105-8.

7. Sharp NJH, JN Kornegay, SD Van Camp, MH Herbstreith, SL Secore, S Kettle, MJ

Dykstra, CD Constantinou, AD Roses, RJ Bartlett: Exon skipping during dystrophin mRNA processing in the canine homologue of Duchenne muscular dystrophy. In Kakulas BA, Howell J Mc, Roses AD (eds). Duchenne Muscular Dystrophy. Animal Models and Genetic Manipulation. Raven Press, 1992, 113-26.

6. Kornegay JN, SM Prattis, DJ Bogan, NJH Sharp, RJ Bartlett, HS Alameddine, MJ

Dykstra: Results of myoblast transplantation in a canine model of muscle injury. In Kakulas BA, Howell J Mc, Roses AD (eds). Duchenne Muscular Dystrophy. Animal Models and Genetic Manipulation. Raven Press, San Diego, 1992, 203-12.

5. Kornegay JN, NJH Sharp, RJ Bartlett, SD Van Camp, CT Burt, WY Hung, L Kwock,

AD Roses: Golden retriever muscular dystrophy: Monitoring for success. In Eastwood AB, Karpati G, Griggs R (eds). Myoblast Transfer Therapy, Plenum Publishing Corp, 1990, 267-72.

4. Bartlett RJ, NJH Sharp, W-Y Hung, JN Kornegay, AD Roses: Molecular markers for

myoblast transplantation in GRMD. In Eastwood AB, Karpati G, Griggs R (eds). Myoblast Transfer Therapy, Plenum Publishing Corp, 1990, 273-8.

3. Sharp NJH, JN Kornegay, SB Lane: The muscular dystrophies. Sem Vet Med Surg

(Sm Anim) 4:133-40, 1989. 2. Kornegay JN: Golden retriever muscular dystrophy: a model of Duchenne muscular

dystrophy. Discuss Neurosci 5:118-23, 1988. 1. Drayer BP, Muraki A, Osborne, JN Kornegay: Gd –DPTA-enhanced magnetic

resonance imaging for study of blood-brain-barrier permeability in naturally occurring and experimentally induced brain infarction. In: Runge VM, Claussen C, Felix R, James AE (eds). Contrast agents in magnetic resonance imaging. Princeton: Excerpta Medica, Inc: 1986, 114-7.

Curriculum Vitae Joe N. Kornegay, DVM, PhD Research Presentations Invited Research Presentations Local 50. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. Scott-Ritchey Research Center, Auburn University, Auburn, AL (2019).

49. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. HudsonAlpha Institute for Biotechnology, Huntsville, AL (2019). 48. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. Asklepios BioPharmaceutical, Inc, Research Triangle Park, NC (2019).

47. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. Lovelace Biomedical, Albuquerque, NM (2019). 46. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. Baylor College of Medicine, Houston, TX (2018). 45. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. Solid Biosciences, Cambridge, MA (2018). 44. Kornegay JN: AAV9-micro-dystrophin therapy in a canine model of Duchenne

muscular dystrophy. The Catholic University of America, Graduate Student Seminar Series, Washington, DC (2018).

43. Kornegay JN, PP Nghiem: Preclinical drug development for DMD: The GRMD model

and immunity to AAV and dystrophin. Pfizer, Inc - Rare Disease Research Unit Cambridge, MA Presented via WebEx (2018).

42. Kornegay JN: Preclinical drug development for DMD. CureDuchenne Cares Family Summit; Emory University – Children’s Healthcare of Atlanta, Atlanta, GA (2017)

41. Kornegay JN: Translational studies in a canine model of Duchenne Muscular

Dystrophy. The Child Health Research Center. Nationwide Children’s Hospital. Columbus, OH (2015).

40. Kornegay JN: Translational studies in a canine model of Duchenne muscular dystrophy.

Texas Children’s Hospital. Houston, TX (2015)

Curriculum Vitae Joe N. Kornegay, DVM, PhD 39. Kornegay JN: Translational lessons learned from a canine model of Duchenne muscular

dystrophy: One man’s view of one health. CST*R Grand Rounds. Texas A&M Health Sciences Center, College Station, TX (2015).

38. Kornegay JN: Translational lessons learned from a canine model of Duchenne muscular

dystrophy Exercise Physiology Seminar Series. Department of Health and Kinesthesiology, Texas A&M University, College Station, TX (2015).

37. Kornegay JN: Overview of canine (CXMD) DMD models. DMD Gene Therapy

Symposium, University of Pennsylvania, Philadelphia, PA (2015). 36. Kornegay JN: Translational studies in a canine model of Duchenne muscular dystrophy.

Powell Gene Therapy Center, University of Florida, Gainesville, FL (2014). 35. Kornegay JN: Translational lessons learned from a canine model of Duchenne muscular

dystrophy. Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA (2012).

34. Kornegay JN: Translational studies in a canine model of Duchenne muscular dystrophy.

TAMU Institute for Neuroscience. Texas A&M University, College Station, TX (2012). 33. Kornegay JN: Preclinical studies in the golden retriever muscular dystrophy (GRMD)

model. Department of Pathobiology Seminar Series. College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX (2012).

32. Kornegay JN: Preclinical studies in the golden retriever muscular dystrophy model.

Comparative Medicine Program, Texas A&M University, College Station, TX (2012). 31. Kornegay JN: Paradoxical muscle hypertrophy in a canine model of DMD, Center for

Duchenne Muscular Dystrophy, University of California-Los Angeles, Los Angeles, CA (2011).

30. Kornegay JN: Muscle hypertrophy in a canine Model. Muscle Metabolism Group,

GlaxoSmithKline, Research Triangle Park, NC (2011). 29. Kornegay JN: Translational lessons learned from a canine model of Duchenne muscular

dystrophy, one health intellectual exchange: Philosophy to practical application of human, animal and environmental health (with James Howard, Jr. and Roger Brown). NC Biotechnology Center, Research Triangle Park, NC (2011).


dystrophy. National Heart, Lung, and Blood Institute. Bethesda, MD (2011). 27. Kornegay JN: A canine model of Duchenne muscular dystrophy. Children’s National

Medical Center, Washington, DC (2011).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 26. Kornegay JN: A canine model of muscle hypertrophy. Johns Hopkins University and

Kennedy Krieger Institute. Baltimore, MD (2010). 25. Kornegay JN: Translational lessons learned from a canine model of Duchenne muscular

dystrophy. University of North Carolina Pathology and Laboratory Medicine Grand Rounds, Chapel Hill, NC (2010).

24. Kornegay JN: Large animal models for transplantation. Stem cell therapies and the

immune response. California Institute for Regenerative Medicine. San Francisco, CA (2009).

23. Kornegay JN: A canine model of Duchenne muscular dystrophy. Neurology Grand

Rounds. University of North Carolina-Chapel Hill, Chapel Hill, NC (2008). 22. Kornegay JN: A canine model of Duchenne muscular dystrophy. Acceleron Pharma,

Cambridge, MA (2008). 21. Kornegay JN: A canine model of Duchenne muscular dystrophy. Neurology Grand

Rounds. Wake Forest University, Winston Salem, NC (2008). 20. Kornegay JN: A canine model of Duchenne muscular dystrophy. Children’s National

Medical Center, Washington, DC (2007). 19. Kornegay JN: A canine model of Duchenne muscular dystrophy: Translational studies.

University of Minnesota School of Medicine Paul and Sheila Wellstone Muscular Dystrophy Center, Minneapolis, MN (2007).

18. Kornegay JN: A canine model of Duchenne muscular dystrophy: Natural History and

Research Findings. University of Minnesota College of Veterinary Medicine, St. Paul, MN (2007).

17. Kornegay JN: A canine model of Duchenne muscular dystrophy. Wyeth

Pharmaceuticals, Cambridge, MA (2006). 16. Kornegay JN: A canine model of Duchenne muscular dystrophy. Merck Research

Laboratories, West Point, PA (2006). 15. Kornegay JN: A canine model of Duchenne muscular dystrophy. University of North

Carolina Department of Pathology and Laboratory Medicine, Chapel Hill, NC (2006). 14. Kornegay JN: A canine model of Duchenne muscular dystrophy. University of North

Carolina Gene Therapy Center, Chapel Hill, NC (2006). 13. Kornegay JN: A canine model of Duchenne muscular dystrophy. The Senator Paul D.

Wellstone Muscular Dystrophy Cooperative Research Center, University of Washington/Fred Hutchinson Cancer Institute, Seattle, WA (2005).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 12. Kornegay JN: A canine model of Duchenne muscular dystrophy. Columbus Children’s

Research Institute, Columbus, OH (2005). 11. Kornegay JN: A canine model of Duchenne muscular dystrophy. University of

Washington, Seattle, WA (2005). 10. Kornegay JN: Comparative oncology: A veterinary neurologist’s perspective.

Oncology Grand Rounds. School of Medicine, University of Missouri, Columbia, MO (2002).

9. Kornegay JN: Phenotypic variation in a canine model of Duchenne muscular dystrophy.

Neurology Grand Rounds, School of Medicine, University of Missouri, Columbia, MO (2000).

8. Kornegay JN: A canine model of Duchenne muscular dystrophy. College of Veterinary

Medicine, University of California (Davis), Davis, CA (1999). 7. Kornegay JN: A canine model of Duchenne muscular dystrophy. College of Veterinary

Medicine, University of Pennsylvania, Philadelphia, PA (1999). 6. Kornegay JN: A canine model of Duchenne muscular dystrophy. Department of

Physiology Seminar Series. Kirksville College of Osteopathic Medicine, Kirksville, MO (1998).

5. Kornegay JN: Muscular dystrophy in man and man's best friend. University of

Missouri Biological Sciences Undergraduate Research Seminar Series. Columbia, MO (1995).

4. Kornegay JN: A canine model of Duchenne muscular dystrophy. Neurology grand

rounds, School of Medicine, University of Miami, Miami, FL (1994). 3. Kornegay JN: Functional studies in a canine model of muscular dystrophy. North

Carolina State University Physiology Seminar Series. Raleigh, NC (1993). 2. Kornegay JN: Golden retriever muscular dystrophy: A model of Duchenne muscular

dystrophy. Neuromuscular Disease Interest Group, University of North Carolina Medical School. Chapel Hill, NC (1986).

1. Kornegay JN: Muscle diseases of dogs. Neuromuscular Disease Interest Group,

University of North Carolina Medical School. Chapel Hill, NC (1983).

Curriculum Vitae Joe N. Kornegay, DVM, PhD State 5. Kornegay JN: Keynote Lecture: AAV9-micro-dystropin therapy in a canine model of

Duchenne muscular dystrophy. Precision Medicine and Muscular Dystrophy: Similarities and Synergies Between Human and Canine Models. University of California-Davis, Davis, CA (2017).

4. Kornegay JN: Keynote Lecture: Translational studies in a canine model of Duchenne

muscular dystrophy. Iowa State University College of Veterinary Medicine Summer Scholars Research Day, Ames, IA (2017).


dystrophy. Chester Hartenstein ’45 Memorial Lecture, College of Veterinary Medicine, Cornell University, Ithaca, NY (2010).

2. Kornegay JN: Keynote address: Translational lessons learned from a canine model of

Duchenne muscular dystrophy. Science of Veterinary Medicine Symposium, College of Veterinary Medicine, University of Georgia-Athens (2009).

1. Kornegay JN: Muscular dystrophy in dogs: Lessons for human rehabilitation. Missouri

State Medical Association. Osage Beach, MO (1996). Regional 5. Kornegay JN: Keynote address: Translational lessons learned from a canine model of

Duchenne muscular dystrophy. Southeastern Veterinary Neurology Meeting, University of Georgia-Athens (2010).

4. Kornegay JN: Pathologic features of a case of cerebral phaeohyphomycosis.

Southeastern Veterinary Pathology Meeting. Tifton, GA (1982). 3. Kornegay JN: Pathologic features of a case of polymyositis. Southeastern Veterinary

Pathology Meeting. Tifton, GA (1980). 2. Kornegay JN: Polymyositis in the dog. Southern Veterinary Neurology Group Meeting.

Atlanta, GA (1978). 1. Kornegay JN: Bacterial meningoencephalitis in the dog. Southern Veterinary

Neurology Group Meeting. Atlanta, GA (1977). National 31. Kornegay JN: Inflammation and immunity in Duchenne: What can we learn from the

GRMD model? Parent Project Muscular Dystrophy Annual Conference. Chicago, IL (2017).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 30. Kornegay JN: One man’s view of one health: Translational lessons learned from a

canine model of Duchenne muscular dystrophy. American College of Veterinary Pathologists Annual Meeting. New Orleans, LA (2016).

29. Kornegay JN, KR Wagner. Comparative medicine team approach: Muscular

dystrophies. One Health: Integrating the Veterinarian Scientist into the Biomedical Research Enterprise. NIH (Office of Research Infrastructure Programs [ORIP]). Bethesda, MD (2015).

28. Kornegay JN, DJ Bogan, JR Bogan, JL Dow, J Wang, Z Fan, LC Warsing, N Liu, RW

Grange, M Ahn, CJ Balog-Alvarez, SW Cotten, M S Willis, C Brinkmeyer-Langford, H Zhu, MA Styner, KR Wagner: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. MDA Scientific Conference, Washington, DC (2015).

27. Kornegay JN: One man’s view of one health: Translational lesions learned from a

canine model of Duchenne muscular dystrophy. Association of American Veterinary Medical Colleges Recognition Lecture. Washington, DC (2014).

26. Kornegay JN: Spontaneous canine models of neuromuscular disease, MDA Scientific

Conference, Washington, DC (2013). 25. Kornegay JN: Translational lesions learned from a canine model of Duchenne muscular

dystrophy. American College of Veterinary Internal Medicine Annual Forum, Denver, CO (2011)

24. Kornegay JN: GRMD biomarkers. Parent Project Muscular Dystrophy Annual

Meeting, Denver, CO (2010). 23. Kornegay JN: Overview of the GRMD model and program at UNC-CH. Parent Project

Muscular Dystrophy Board Meeting, Chicago, IL (2009). 22. Kornegay JN: National canine muscular dystrophy core (NCMDC). Wellstone MDCRC

Face to Face Meeting. Iowa City, IA (2009). 21. Kornegay JN: Update on muscular dystrophy. American College of Veterinary Internal

Medicine Annual Forum. San Antonio, TX (2008). 20. Guttridge D, C Borlongan, R Ferrante, J Kornegay, P Robbins, H Stedman (Working

Group): Development, use, and relevance of animal models. National Institute of Neurological Disorders and Stroke Translational Research Grantee Workshop. Washington, DC (2008).

19. Kornegay JN, J Rafael-Fortney, M Swanson, K Wagner (Working Group): Animal

Models and Preclinical Endpoints. NIH Workshop on Translational Research in Muscular Dystrophy. Washington, DC (2007).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 18. Kornegay JN: Phenotypic evaluation of the GRMD dog. Wellstone Center Workshop,

Pre-clinical testing for Duchenne dystrophy: End-points in the mdx mouse. Children’s National Medical Center, Washington, DC (2007).

17. Kornegay JN: Use of the golden retriever muscular dystrophy model in developmental

therapeutics. American Society of Gene Therapy Annual Meeting, Minneapolis, MN (2004).

16. Kornegay JN: The use of animal models in developmental therapeutics. American

Academy of Physical Medicine and Rehabilitation Annual Meeting. Phoenix, AZ (2004). 15. Bartlett RJ, MM Denis, JN Kornegay, JM Bogan, DJ Bogan, L Inverardi, C Ricordi:

Can genetic surgery be used to revert muscular dystrophy mutations in live animals? 1st Annual Meeting of the American Society of Gene Therapy, Seattle, WA (1998).

14. Kornegay JN: The Duchenne muscular dystrophy center: GRMD core status report.

Presented to the Advisory Committee of the DMD Center. Pittsburgh, PA (1997). 13. Kornegay JN: Golden retriever muscular dystrophy: Phenotypic studies. Exploring

Treatment Options Workshop (sponsored by the Muscular Dystrophy Association). Tucson, AZ (1996).

12. Kornegay JN: The golden retriever muscular dystrophy model and its role in clinical

trials. Current and Future Management of Duchenne Muscular Dystrophy (conference sponsored by the University of Pittsburgh Human Gene Therapy Center). Pittsburgh, PA (1996).

11. Kornegay JN: Golden retriever muscular dystrophy: Its role in DMD research. Gene

Therapy Conference (sponsored by the Muscular Dystrophy Association). Tucson, AZ (1991).

10. Kornegay JN: Myoblast transplantation. American College of Veterinary Internal

Medicine Annual Forum. New Orleans, LA (1991). 9. Kornegay JN: Myoblast transplantation in notexin-injured canine muscle. American

Association of Neuropathologists Annual Meeting. Baltimore, MD (1991). 8. Kornegay JN: Golden retriever myopathy. American College of Veterinary Internal

Medicine Annual Forum. Washington, DC (1988). 7. Kornegay JN, R LeCouteur, R Higgins: Progressive cerebellar disease of Brittany

spaniel dogs. American College of Veterinary Internal Medicine Annual Forum. Washington, DC (1988).

6. Kornegay JN: Cerebellar vermian hypoplasia in dogs. American College of Veterinary

Internal Medicine Annual Forum. Washington, DC (1986).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 5. Kornegay JN: Dysmyelinogenesis of dogs. American College of Veterinary Internal

Medicine Annual Forum. San Diego, CA (1985). 4. Kornegay JN: Marek's disease virus-induced transient paralysis. American College of

Veterinary Internal Medicine Annual Forum. Washington, DC (1984). 3. Kornegay JN: Golden retriever myopathy. American College of Veterinary Internal

Medicine Annual Forum. Washington, DC (1984). 2. Kornegay JN: Brain herniation in animals. American Veterinary Neurology

Association. San Antonio, TX (1983). 1. Kornegay JN: Somatosensory evoked potential in the dog. American Veterinary

Neurology Association. Washington, DC (1980). International 30. Kornegay JN, Detwiler DA: Isolation, culture, and characterization of primary canine

satellite cells from the GRMD model. World Veterinary Association Congress. Barcelona, SPAIN (2018).

29. Kornegay JN: Overview of seizures: Classification to therapy. Safety Pharmacology

Society Annual Meeting. EEG Waveform Recognition Workshop. Prague, CZECH REPUBLIC (2015).

28. Kornegay JN: Biomarkers in dog models of DMD. Relevance for clinical studies Update on standard operating procedures in preclinical research for DMD and SMA Amsterdam, NETHERLANDS (2015). 27. Kornegay JN: The role of a canine model in muscular dystrophy translational research:

AAV-based gene therapy. 24th Annual Symposium of the ESVN, Trier, GERMANY (2011).

26. Kornegay JN: The role of a canine model in muscular dystrophy translational research:

Muscle hypertrophy – Friend or foe? 24th Annual Symposium of the ESVN, Trier, GERMANY (2011).

25. Kornegay JN, Bogan DJ, Bogan JR, Dow JL, Wang J, Fan Z, Warsing LC, Grange RW,

Styner MA, Wagner KR: Disproportionate muscle hypertrophy increases phenotype severity in myostatin-heterozygous GRMD (GRippet) dogs. Ascona, SWITZERLAND (2011).

24. Kornegay JN: Animal model assessment (Co-chair with Markus Ruegg). Bringing

down the barriers, TREAT-NMD (Co-Sponsored by NIH). Brussels, BELGIUM (2009).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 23. Kornegay JN: Workshop meeting: Preclinical testing in DMD. Zurich Irchel

University, Zurich, SWITZERLAND (2008). 22. Kornegay JN: A canine model of Duchenne muscular dystrophy. Veterinary Faculty of

the University of Berne, Bern, SWITZERLAND (2008). 21. Kornegay JN: A canine model of Duchenne muscular dystrophy. Institut de Myologie,

Paris, FRANCE (2008). 20. Kornegay, JN: US veterinary school curricula: Similarities and differences from the

European schools. International Veterinary Conference. Kuwait City, KUWAIT (2004). 19. Kornegay, JN: Cerebellar diseases of dogs and cats. Recent Advances in Animal Health

and Production (26th Annual Meeting). Faculty of Veterinary Medicine, Universiti Putra Malaysia. Serdang, MALAYSIA (2003).

18. Kornegay, JN: Breed-associated meningitis. Recent Advances in Animal Health and

Production (25th Annual Meeting). Faculty of Veterinary Medicine, Universiti Putra Malaysia. Serdang, MALAYSIA (2002).

17. Kornegay, JN: A canine model of DMD. Recent Advances in Animal Health and

Production (24th Annual Meeting). Faculty of Veterinary Medicine, Universiti Putra Malaysia. Serdang, MALAYSIA (2001).

16. Kornegay JN, Bogan JR, Bogan DJ, Okamura CS, Childers MK: Phenotypic variation

in a canine model of DMD. Presented at the ceremony marking the opening of the canine facility at the National Center of Neurology and Psychiatry, Tokyo, JAPAN (2001).

15. Childers MK, CS Okamura, MJ Sullivan, DJ Bogan, JR Bogan, JN Kornegay: Cranial

sartorius myofibers of the neonatal GRMD dog are preferentially permeable to Evans blue dye. IX International Congress on Neuromuscular Diseases, Adelaide, AUSTRALIA (1998).

14. Kornegay JN, DJ Bogan JR Bogan, DD Cundiff, CS Okamura, MK Childers:

Phenotypic variation in dogs with golden retriever muscular dystrophy (GRMD). IXth International Congress on Neuromuscular Diseases, Adelaide, AUSTRALIA (1998).

13. Schatzberg S, L Anderson, S Wilton, J Kornegay, C Mann, G Solomon, N Sharp:

Overcoming the golden retriever muscular dystrophy (GRMD) frameshift mutation. IXth International Congress on Neuromuscular Diseases, Adelaide, AUSTRALIA (1998).

12. Childers MK, CS Okamura, MJ Sullivan, DJ Bogan, JR Bogan, JN Kornegay:

Phenotypic variation among pelvic limb muscles in dogs with golden retriever muscular dystrophy (GRMD). Satellite Symposium, IXth International Congress on Neuromuscular Diseases, Perth, AUSTRALIA (1998).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 11. Kornegay JN: Golden retriever muscular dystrophy: Relevance to developmental

therapeutics. Research Department, Hoechst Pharmaceutical Co., Wiesbaden, GERMANY (1992).

10. Kornegay JN: Results of myoblast transplantation in a canine model of muscle injury.

Presented at the Animal Models for Duchenne Muscular Dystrophy and Genetic Manipulation Workshop. Perth, Western Australia, AUSTRALIA (1991).

9. Kornegay JN: Golden retriever muscular dystrophy: The model and relevance to

developmental therapeutics. Presented at the Animal Models for Duchenne Muscular Dystrophy and Genetic Manipulation Workshop. Perth, Western Australia, AUSTRALIA (1991).

8. Kornegay JN: Golden retriever muscular dystrophy: A model of Duchenne muscular

dystrophy. Presented to the faculty and staff of the School of Veterinary Medicine, Cambridge University, Cambridge, ENGLAND (1990).


dystrophy. Presented to the staff of the Muscular Dystrophy Group Research Laboratories, Newcastle, ENGLAND (1990).


dystrophy. Presented to the faculty and staff of the Istituto di Clinica Neurologica, Universita di Milano, Milan, ITALY (1990).

5. Kornegay JN: Animal models of neurologic disease. Presented to the research staff of

Fidia Research Laboratories, Abano Terme, ITALY (1990). 4. Kornegay JN: Golden retriever muscular dystrophy: A model of Duchenne muscular

dystrophy. Presented to the faculty and staff of the neurology and neurosurgery sections at the College of Medicine, University of Limoges, Limoges, FRANCE (1989).

3. Kornegay JN: Pathologic changes in experimental and spontaneous canine myopathies.

Actualities de la Regeneration Musculaire et de la Jonction Neuromusculaire, Paris, FRANCE (1989).

2. Kornegay JN: Golden retriever muscular dystrophy: Monitoring for success.

International Conference on Myoblast Transfer, New York, NY (1989). 1. Kornegay JN: Cerebellar vermian hypoplasia in dogs. School of Veterinary Medicine,

Melbourne University. Melbourne, AUSTRALIA (1986).

Curriculum Vitae Joe N. Kornegay, DVM, PhD TEACHING RECORD Teaching Experience Texas A&M University (2013-present) Professional (DVM) Student Curriculum VIBS 948-314 – Using Your DVM in Clinical Research (Elective for third year DVM students) 2-hour lecture and 2 hour laboratory; team taught with Dr. Candice Brinkmeyer-

Langford; Course coordinator (2013-2015) VIBS 913 – Functional Neuroanatomy and Lesion Localization Laboratory course (Instructor – Three 4-hour labs/week for 5 weeks) (2013-2014) Graduate Curriculum NRSC 601 Principles of Neuroscience Part 1. Two 1 hr lectures (Phenotypic Variation and Gene

Therapy) (2015-present) VIBS 670 Environmental Toxicology. 3 hr lecture (Toxic Myopathies) (2016-present) GS-TB-409. Method and Logic of Translational Biology, Baylor College of Medicine, Two 1 hr

lectures (Phenotypic Variation and Gene Therapy) (2016) University of North Carolina-Chapel Hill (2006-2013) Graduate Curriculum Pathology 716 - Molecular and Cellular Pathophysiology of Disease: Systemic Pathology 2 hr neuropathology laboratory (2007-2011) Pathology 713 - Molecular and Cellular Pathophysiologic Basis of Disease: Mechanisms of

Disease. 1 hr lecture (Mechanisms of Genetic Disease: Phenotypic Variation) (2008- present); 1 hr lecture (Gene therapy) (2010-2013)

Pathology 723 - Translational Pathology and Laboratory Medicine. 1 hr lecture (Translational Therapies in Muscular Dystrophy) (2009-2011)

University of Missouri-Columbia (1994-2006) Undergraduate Curriculum AS 140 - Introductory course to companion animals; Behavior (2 lectures) (1997-2000)

Curriculum Vitae Joe N. Kornegay, DVM, PhD Professional (DVM) Student Curriculum VBmS 504 - Freshman level course (Veterinary Physiology): Muscle/neuromuscular physiology

(laboratory) (1996-2006) VBmS 500 - Freshman level course (Veterinary Anatomy): Neuroanatomical correlation

(laboratory) (1996-2006) VMS 604 - Sophomore level course (Companion Animal Medicine): Spinal cord and

neuromuscular diseases (1994-2004); Neuromuscular diseases (2005-2006) Graduate Student Curriculum VMS 415 - Advanced Studies in Veterinary Medicine - Neurology: Neuromuscular diseases,

CNS inflammatory diseases (4 lectures) (1997; 2001); Muscle diseases (1 lecture) (2003) VMS 301 - Advanced Topics in Emergency and Critical Care: Cranial and spinal trauma (1995) North Carolina State University (1982-1993) Professional (DVM) Student Curriculum VMC 817 - Freshman level course: Introduction to principles of the neurological examination and lesion localization VMC 837 - Sophomore level course: Neurological examination VMC 857 - Junior level course: Introduction to clinical cases in the hospital VMM 841 - Sophomore level course: Neuropathology VMC 861 - Junior level course: Neurology (Overall course coordinator, 1983-1990) VMF 852 - Junior level course: Ruminant Neurology (1-2 lectures yearly) VMC 882 - Senior level course: Specialty Block in Neurology/Neurosurgery Graduate Student Curriculum VMS 642 - Graduate neuropathology (2 laboratories) (1984-1993; alternate years) VMS 562 - Graduate toxicology (2 lectures) (1983) University of Georgia (1976-1982) Professional (DVM) Student Curriculum Physical Diagnosis Junior Surgery - Laboratory Small Animal Clinics - Neurology and Neurosurgery Neuropathology General Pathology

Curriculum Vitae Joe N. Kornegay, DVM, PhD Instructional Development Teaching Aids and Auto-tutorial Programs Prepared Interactive Canine Pelvic Limb Muscle Atlas (NCSU: Thrall DE, Sunico S, Smallwood JE,

Robertson ID; UNC-CH: Marc C, Hamel C, Chen D, Kornegay J, Styner M) (2010). (http://3dvetanatomy.ncsu.edu/Home.html).

Neuropathology (resident review material incorporating digitalized slides - Aperio) (2009, 2012) Neuropathology (resident review material) (2003) Myopathology (1984) Neuropathology: Cytopathology, Malacia, Hemorrhage, Edema, Inflammation, Neoplasia, Brain

Herniation, Developmental Lesions (1983) General Pathology: Hemorrhage (1981) General Pathology: Edema (1981) Continuing Education Lectures and Reviews Local 44. Neurolocalization for the general practitioner (with Stacey Sullivan), Animal Specialty

Group. Los Angeles, CA (2011). 43. Spinal cord diseases. Southeast Missouri District Meeting. Cape Girardeau, MO (2000). 42. Neuromuscular diseases. West Houston Veterinary Medical Association. Houston, TX

(1998). 41. Feline neurology, Inflammatory CNS diseases. Chicago Veterinary Medical Association.

Chicago, IL (1997). 40. Practical case studies in neurology. Redwood Empire Veterinary Medical Association.

Santa Rosa, CA (1997). 39. The clinical presentations and pathology of CNS neoplasms in small animals. Tuskegee

University Annual Conference, Tuskegee, AL (1994). 38. The Eleventh Annual Frank W. Jordan Seminar, Problems in neurology. Kansas State

University. Manhattan, KS (1994). 37. Spinal cord diseases of dogs and cats. Kansas City Veterinary Medical Association.

Kansas City, MO (1994). 36. Problems in neurology. Chicago Veterinary Medical Association. Chicago, IL (1994). 35. Problems in neurology. Greater Des Moines Veterinary Medical Association. West Des

Moines, IA (1994).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 34. Problems in neurology. Nashville Veterinary Medical Association. Nashville, TN

(1994). 33. Spinal cord diseases. Southeast Louisiana Veterinary Association. New Orleans, LA

(1994). 32. Management of refractory seizures. Central Virginia Veterinary Medical Association.

Richmond, VA (1993). 31. Problems in neurology. Baltimore Veterinary Medical Association. Baltimore, MD

(1993). 30. Major spinal cord diseases of dogs and cats. Dallas Veterinary Medical Association,

Dallas, TX (1993) 29. Principles of the neurologic examination. Presented to the technical staff of Norwich

Eaton Pharmaceuticals, Inc. Norwich, NY (1991). 28. Feline neurology. Noon seminar series for practicing veterinarians (with SJ Wheeler).

College of Veterinary Medicine, North Carolina State University, Raleigh NC (1991). 27. Problems in neurology. Cleveland Academy of Veterinary Medicine. Cleveland, OH

(1991). 26. Clinical overview of veterinary computed tomography. Veterinary CT Imaging, Inc.

Chicago, IL (1990). 25. Paresis and paralysis. Central Arizona Veterinary Medical Association. Sedona, AZ

(1990). 24. Problems in neurology, Management of refractory seizures. Denver Area Veterinary

Medical Society. Denver, CO (1989). 23. Disorders causing tremor: Cerebellar diseases and hypomyelination. Continuing

Education Lecture Series, The Animal Medical Center, New York, NY (1989). 22. Feline neurology. Dallas Veterinary Medical Association. Dallas, TX. (1989). 21. Central nervous system trauma. Central NC Veterinary Medical Association. High

Point, NC (1987). 20. Neurologic diseases of young dogs and cats. Austin Veterinary Medical Association.

Austin, TX (1987). 19. Neurologic diseases of young dogs and cats. East Texas Veterinary Medical Association.

Tyler, TX (1987).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 18. Neurologic diseases of young dogs and cats. Harris County Veterinary Medical

Association. Houston, TX (1987). 17. Feline neurology. Military Veterinarians. Fort Bragg, NC (1986). 16. Vertebral diseases of large breed dogs. Military Veterinarians. Fort Bragg, NC (1985). 15. Neurologic lesion localization, Problems in neurology. Battle Creek Veterinary Medical

Association. Battle Creek, MI (1985). 14. Canine myopathies. Florence, South Carolina Veterinary Medical Association. Florence,

SC (1984). 13. Management of intervertebral disk disease. Triangle Veterinary Medical Association.

Durham, NC (1983). 12. Management of intervertebral disk disease. Twin States Veterinary Medical Association.

Rockingham, NC (1983). 11. Cerebrospinal fluid evaluation, Principles of therapy for the nervous system, Tetraparesis

in dogs. Veterinary Clinical Neurology Conference, University of Georgia. Athens, GA (1982).

10. Vertebral diseases of dogs. Columbia, South Carolina Veterinary Medical Association.

Columbia, SC (1982). 9. Vertebral diseases in dogs. Harris County Veterinary Medical Association. Houston, TX

(1980). 8. Neuromuscular diseases, Cerebrospinal fluid collection and interpretation,

Neuroophthalmology, Radiographic diagnosis of intervertebral disk disease. Veterinary Clinical Neurology Conference, University of Georgia. Athens, GA (1980).

7. Diskospondylitis. Veterinary Clinical Neurosurgery Conference, University of Georgia.

Athens, GA (1980). 6. Thoracolumbar hemilaminectomy and fenestration, Cervical laminectomy and

fenestration. Veterinary Clinical Neurosurgery Conference Wet Lab, University of Georgia. Athens, GA (1980).

5. Management of seizures. Columbia, South Carolina Veterinary Medical Association.

Columbia, SC (1980). 4. Principles of neurologic lesion localization and disease diagnosis. Tidewater Veterinary

Medical Association. Norfolk, VA (1980).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 3. Localization of neurologic lesions. North Georgia Veterinary Medical Association.

Athens, GA (1979). 2. Cerebrospinal fluid collection and interpretation in the dog, Radiographic diagnosis of

intervertebral disk disease. Neurology Conference, University of Georgia. Athens, GA (1977).

1. Thoracolumbar hemilaminectomy and fenestration, Cervical fenestration. Neurosurgery

Wet Lab, Neurology Conference, University of Georgia. Athens, GA (1977). State 33. Neurology case presentations. Ninth Annual Clinical Neurology Conference, College of

Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX (2013).

32. Case studies in neurology. Eighth Annual Clinical Neurology Conference, College of

Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX (2012).

31. Misconceptions in neurology, Case Studies in Neurology. Seventh Annual Clinical

Neurology Conference, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX (2011).

30. Case studies in neurology - Monoparesis (peripheral nerve disease); Paraparesis (spinal

cord disease); Tetraparesis (LMN disease); Tetraparesis (intracranial disease). North Carolina Veterinary Conference, Raleigh, NC (2009).

29. A practical approach to lesion localization and the neurologic examination. Inland

Empire VMA 13th Annual Ski Meeting, Schweitzer Mountain Resort, Sandpoint, ID (2006).

28. Problems in neurology. Illinois Veterinary Medical Association, Chicago, IL (2003). 27. Case studies in feline neurology. Kansas State Veterinary Medical Association.

Overland Park, KS (1998). 26. Vertebral diseases of large breed dogs. University of Missouri Annual Alumni

Conference. Columbia, MO (1996). 25. Feline neurology, Disk disease, Diskospondylitis, Breed-specific meningitis. North

Carolina Veterinary Medical Association, Charlotte, NC (1996). 24. Problems in neurology. Minnesota Veterinary Medical Association. St. Paul, MN

(1996).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 23. Feline neurology, Intervertebral disk disease, Vertebral diseases of large breed dogs.

Texas Veterinary Medical Association. Arlington, TX (1996). 22. Intervertebral disk disease, Diskospondylitis. Missouri Veterinary Medical Association,

Osage Beach, MO (1995). 21. Feline neurology, Spinal cord diseases of dogs and cats, Seizures, Cranial trauma,

University of Georgia Annual Alumni Conference, Athens, GA (1995). 20. Neurologic case discussions. University of Missouri College of Veterinary Medicine

Annual Alumni Conference, Columbia, MO (1995). 19. Neurologic disorders of dogs and cats. Third Annual Oregon State University College of

Veterinary Medicine Continuing Education Program, Corvallis, OR (1995). 18. Canine muscle diseases. Missouri Veterinary Medical Association, Osage Beach, MO

(1994). 17. Feline neurology, Breed-specific meningitis, Cerebellovestibular dysfunction in cats,

Management of refractory seizures, Management of intervertebral disk disease, The trembling dog, Central nervous system trauma. Michigan Veterinary Medical Association. Lansing, MI (1993).

16. Spinal cord diseases, Neuromuscular diseases. Texas Veterinary Medical Association.

Houston, TX (1991). 15. Imaging of brain neoplasia. Winter Symposium of the North Carolina Academy of

Laboratory Animal Medicine. Durham, NC (1991). 14. Principles of neurologic lesion localization, Problems in neurology. Illinois State

Veterinary Medical Association 108th Annual Meeting and Convention. Springfield, IL (1989).

13. Feline neurology, Vertebral diseases of large breed dogs, Seizures, Intervertebral disk

disease. Texas Veterinary Medical Association. Fort Worth, TX (1987). 12. Feline neurology, Vertebral diseases of large breed dogs, Seizures, Intervertebral disk

disease. University of Minnesota Annual Fall Conference for Veterinarians. Saint Paul, MN (1986).

11. Neurologic lesion localization, Problems in neurology. South Carolina Academy of

Small Animal Practice. Columbia, SC (1985). 10. Neurologic lesion localization, Problems in neurology. Texas A&M University Annual

Homecoming Short Course. College Station, TX (1985).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 9. Diskospondylitis. North Carolina Veterinary Medical Association. Raleigh, NC (1984). 8. Neurologic lesion localization, Problems in neurology. North Carolina Academy of

Small Animal Practice. Apex, NC (1984). 7. Feline neurology. North Carolina Veterinary Medical Association. Asheville, NC (1983). 6. Neuromuscular diseases, Management of seizures in small animals. North Carolina

Veterinary Medical Association. Wilmington, NC (1982). 5. Vertebral diseases. Georgia Veterinary Medical Association. Jekyll Island, GA (1980). 4. Feline neurology. University of Georgia Annual Alumni Conference. Athens, GA

(1980). 3. Canine myopathies and diseases of the neuromuscular junction. Cornell Annual

Conference for Veterinarians. Ithaca, NY (l979). 2. Localization of neurologic lesions. Iowa State Veterinary Medical Association. Des

Moines, IA (l979). 1. Polymyositis, Fibrocartilaginous thromboembolism in the dog. University of Georgia

Annual Alumni Conference. Athens, GA (1978). Regional 27. Problems in neurology (monoparesis, paraparesis, tetraparesis (spinal cord and

neuromuscular), ataxia (cerebellar vestibular, and forebrain disease). Southwest Veterinary Symposium. Fort Worth, TX (2006).

26. Neuromuscular diseases I and II, Feline neurology I and II, Muscle biopsy. Western

States Veterinary Conference. Las Vegas, NV (2006). 25. Neurologic examination (with Michael D. Lorenz), Intervertebral disk disease, Vertebral

diseases of large breed dogs, Breed-associated meningitis and encephalitis, Feline neurology, Canine myopathies. Southwest Veterinary Symposium. Fort Worth, TX (2005).

24. Breed-specific meningitis, Inflammatory myopathies, Degenerative myopathies, Feline

monoparesis/paraparesis, Feline tetraparesis, Feline intracranial syndromes, Management of the paralyzed dog, Western States Veterinary Conference. Las Vegas, NV (2000).

23. Intervertebral disk disease, Neuromuscular diseases, Vertebral diseases of large breed

dogs, Monoparesis, Breed-associated meningitis, Management of the paralyzed dog. Central States Veterinary Conference. Kansas City, MO (1999).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 22. Problems in neurology. Atlantic Coast Veterinary Conference. Atlantic City, NJ (1998). 21. Practical problems in neurology, Veterinary Post-graduate Institute. San Diego, CA

(1997). 20. Practical problems in neurology. Veterinary Post-graduate Institute. Monterey, CA

(1995). 19. Lumbosacral diseases, Feline neurology, Management of the paralyzed dog, Canine

muscle diseases, Neurology case discussions. Central States Veterinary Conference. Kansas City, MO (1995).

18. Practical problems in neurology, Veterinary Post-graduate Institute. Phoenix, AZ (1995). 17. Feline neurology, Cauda equina disease, Breed-specific meningitis. Wild, Wild, West

Veterinary Conference. Reno, NV (1995). 16. Practical problems in neurology, Veterinary Post-graduate Institute. Seattle, WA (1995). 15. Spinal cord diseases, Muscle diseases. Western States Veterinary Conference. Las

Vegas, NV (1994). 14. Spinal cord diseases of dogs and cats, Neuromuscular diseases of dogs and cats,

Management of the paralyzed dog, Brain neoplasia (technician program). California, Arizona, Nevada Joint Veterinary Conference. San Diego, CA (1994).

13. Degenerative muscle disease, Inflammatory muscle disease, Spondylitis and

diskospondylitis, Spinal neoplasia, Intervertebral disk disease: treatment guidelines, Muscle biopsy, General approach to spinal cord disease. North American Veterinary Conference. Orlando, FL (1993).

12. Feline neurology, Canine muscle disease, Cerebrospinal fluid collection. Western States

Veterinary Conference. Las Vegas, NV (1993). 11. A potpourri of diagnostic neuropathology. Keynote lecture for Southeastern Veterinary

Pathology Conference. Tifton, GA (1991). 10. Principles of neurologic lesion localization, Lumbosacral spinal disease, Canine muscle

disease, Management of refractory seizures. Southern California Veterinary Medical Association. Long Beach, CA (1989).

9. Thoracolumbar disk disease, Canine muscle disease, The ataxic cat, Canine distemper:

the neurologic form revisited, Muscle biopsy. Western States Veterinary Conference, Las Vegas. NV (1989).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 8. Brain and spinal neoplasia of dogs and cats, Inflammatory brain diseases of dogs and

cats, The ataxic cat, Canine muscle disease. Western Region American Animal Hospital Association Meeting. San Antonio, TX (1989).

7. Feline neurology, Canine myopathies, Lumbosacral disease, Management of the

paralyzed dog (technician program). American Animal Hospital Association. Northwest Region Meeting. Seattle, WA (1988).

6. Vertebral diseases of large breed dogs, Feline neurology, Hypocalcemia in dogs. Eastern

States Veterinary Conference. Orlando, FL (1985). 5. Neurologic lesion localization, Problems in neurology. New England Veterinary Medical

Association. Waterville Valley, NH (1985). 4. Problems in neurology, Polymyositis, Canine myopathies, Diskospondylitis. Eastern

States Veterinary Conference. Orlando, FL (1984). 3. Feline neurology. Carnation Symposium for Veterinarians. Boston, MA (1983). 2. Feline infectious peritonitis: CNS manifestations. American Animal Hospital

Association Southeast Regional Meeting. Raleigh, NC (1982). 1. Feline neurology. Fifth Annual Carnation Symposium for Veterinarians. Irvine, CA

(1982). National 23. Neuropathology Review (presented to trainees). Comparative Biomedical Scientist

Training Program (CBSTP). National Cancer Institute (NIH). Bethesda, MD (2019). 22. Translational lessons learned from a canine model of Duchenne muscular dystrophy.

National SAVMA Symposium 2017, College Station, TX (2017). 21. Resident review session – Neuropathology. American College of Veterinary Internal

Medicine Annual Forum. Indianapolis, IN (2015). 20. Resident review session – Neuropathology. American College of Veterinary Internal

Medicine Annual Forum. New Orleans, LA (2012). 19. CNS neuropathology. Biannual Course in Veterinary Neuroscience and Advanced

Clinical Neurology/Neurosurgery (Resident Review Session). Athens, GA (2012). 18. CNS neuropathology. Biannual Course in Veterinary Neuroscience and Advanced

Clinical Neurology/Neurosurgery (Resident Review Session). Raleigh, NC (2008).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 17. CNS neuropathology. Biannual Course in Veterinary Neuroscience and Advanced

Clinical Neurology/Neurosurgery (Resident Review Session). Raleigh, NC (2006). 16. Crazy cats: Cerebral dysfunction of cats, Falling felines with vestibular disorders, Spinal

cord disease of cats, Feline neuromuscular diseases. American College of Veterinary Internal Medicine Annual Forum. Charlotte, NC (2003).

15. CNS neuropathology. Biannual Course in Veterinary Neuroscience and Advanced

Clinical Neurology/Neurosurgery (Resident Review Session). Raleigh, NC (2003). 14. A problem-oriented approach to small animal neurology. American Board of Veterinary

Practitioners Core Program. Associated with the American College of Veterinary Internal Medicine 17th Annual Forum. Chicago, IL (1999).

13. Intervertebral disk disease, Diskospondylitis, Management of ataxic animals, Muscle

biopsy, Breed-associated meningitis. North American Veterinary Conference, Orlando, FL (1995).

12. Phenotypic features of canine X-linked muscular dystrophy, Neurologic case discussions

(with RA LeCouteur). American College of Veterinary Internal Medicine Annual Forum. Orlando, FL (1995).

11. Diskospondylitis revisited, Breed-associated meningitis, The X-linked muscular

dystrophies. American College of Veterinary Internal Medicine Annual Forum. New Orleans, LA (1991).

10. Problems in neurology, Feline neurology. American Veterinary Medical Association.

San Antonio, TX (1990). 9. Core course in neurology (with CL Chrisman and RA LeCouteur). American Animal

Hospital Association Annual Meeting. Washington, DC (1988). 8. Feline cerebellar disease. American College of Veterinary Internal Medicine Annual

Forum. Washington, DC (1988). 7. Canine muscle disease, Neurology CPC. American College of Veterinary Internal

Medicine Annual Forum. Washington, DC (1986). 6. Pathologic diagnosis of spinal cord diseases, Central nervous system and peripheral

nerve/nerve root neoplasia. American College of Veterinary Surgeons Annual Veterinary Surgical Forum. Chicago, IL (1986).

5. The trembling dog, Intervertebral disk disease, Feline neurology. American Animal

Hospital Association Annual Meeting. New Orleans, LA (1986).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 4. Lesions of the lumbosacral plexus and intumescence, Feline neurology. American

Veterinary Neurology Association. Orlando, FL (1985). 3. Central nervous system infections, Vertebral diseases. American Animal Hospital

Association Annual Meeting. Orlando, FL (1985). 2. Intracranial neoplasia of dogs and cats, Cerebellar diseases of dogs. American College of

Veterinary Internal Medicine Annual Forum. San Diego, CA (1985). 1. Diseases of the spinal cord, Bacterial and fungal infections of the CNS. American

College of Veterinary Internal Medicine Annual Forum. Washington, DC (1984). International 35. Practical management of animals with neurologic disease. Malaysian Small Animal

Veterinary Association, Kuala Lumpur, MALAYSIA (2010). 34. Misconceptions in neurology (Plenary Session), Internship-residency program: Structure

and setup in the North American system, Spinal cord diseases, Neuromuscular diseases, Veterinary Practitioner Association of Thailand (VPAT) Regional Veterinary Congress (VRVC). Bangkok, THAILAND (2010).

33. Resident Review Session – Neuropathology. American College of Veterinary Internal

Medicine Annual Forum. Montreal, CANADA (2009). 32. Clinical neurology. Presented to the students and faculty of the Ross University College

of Veterinary Medicine, St. Kitts, WEST INDIES (2005). 31. A practical approach to clinical neurology. Presented to students and faculty of the

Chonnam National University College of Veterinary Medicine, Gwangju, SOUTH KOREA (2005).

30. A practical approach to clinical neurology. Presented to students and faculty of the Seoul

National University College of Veterinary Medicine, Seoul, SOUTH KOREA (2005). 29. Neurology seminar. Malaysian Small Animal Veterinary Association. University Putra

Malaysia, Selangor. MALAYSIA (2004). 28. Neurology workshop for practitioners. The Veterinary Practitioner Association of

Thailand. Mahidol University, Bangkok, THAILAND (2004). 27. Neurosurgery. Japanese Animal Hospital Association. Fukuoka, Osaka, and Tokyo,

JAPAN (2003). 26. Neurosurgery (lecture and wet-lab). Workshop for Practicing Veterinarians. Universiti

Putra Malaysia. Selangor, MALAYSIA (2003).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 25. Common feline neurologic disorders, Canine and feline vestibular disease, Canine and

feline myopathies, Spinal cord diseases of large breed dogs. XXIV Brazilian Congress. National Association of Small Animal Veterinarians (ANCLIVEPA). Belo Horizonte, BRAZIL (2003).

24. Problems in neurology, Neurologic lesion localization. Japanese Animal Hospital

Association. Fukuoka, Osaka, and Tokyo, JAPAN (2002). 23. Problems in neurology. Workshop for Practicing Veterinarians. Universiti Putra

Malaysia, Selangor, MALAYSIA (2001). 22. Neurology and neurosurgery (with HB Seim; 30 hour course over 5 days). Post-Graduate

Foundation in Veterinary Science. Sydney, AUSTRALIA (1996) 21. Peripheral nerve, root, and lumbosacral trauma; Intervertebral disk disease - diagnosis

and surgical management; Spinal cord trauma - pathogenesis and management. 5th International Veterinary Emergency and Critical Care Symposium. San Antonio, TX (1996).

20. Practical problems in neurology, Veterinary Post-graduate Institute. Vancouver, British

Columbia, CANADA (1996). 19. Spinal cord diseases, Brain diseases. XVII Brazilian Congress. National Association of

Small Animal Veterinarians (ANCLIVEPA). Vitoria, BRAZIL (1995). 18. Problems in neurology, Neurologic lesion localization. Japanese Animal Hospital

Association. Fukuoka, Osaka, and Tokyo, JAPAN (1994). 17. The neurologic examination. Presented to the professional staff of MSD-Chibret

(Subsidiary of Merck Sharp and Dohme Research Laboratories [USA]), Clermont-Ferrand, FRANCE (1993).

16. Syringomyelia: Pathogenesis and diagnosis. 7th Annual Symposium of the European

Society of Veterinary Neurology. Mindenhall, ENGLAND (1993). 15. Neurosurgery: Principles, indications, and procedures. World Small Animal Veterinary

Association. Berlin, GERMANY (1993). 14. Vertebral diseases of large dogs, Breed-specific meningitis, Intervertebral disk disease,

Feline neurology. Ontario Veterinary Medical Association. Toronto, CANADA (1992). 13. Core Course in Veterinary Neurology. Region Djursjukhuset IStrömsholm. Strömsholm,

SWEDEN (1991). 12. Imaging brain neoplasia. European Society of Veterinary Neurology Annual Meeting.

Vienna, AUSTRIA (1991).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 11. Diskospondylitis revisited, The X-linked muscular dystrophies. World Small Animal

Veterinary Association. Vienna, AUSTRIA (1991). 10. Pathogenesis and diagnosis of intervertebral disk disease, Feline neurology, Vertebral

diseases of large breed dogs. Italian Veterinary Neurology Study Group. Ferrara, ITALY (1991).

9. Diskospondylitis revisited, The X-linked muscular dystrophies. Metropolitan

Practitioners Branch. Australian Veterinary Association of New South Wales. Sydney, AUSTRALIA (1991).

8. The X-linked muscular dystrophies, Diskospondylitis. Collegium Chirugicum.

Mannheim, GERMANY (1990). 7. Cerebellar lesion localization and disease. College of Veterinary Medicine, Free

University of Berlin, Berlin, GERMANY (1990). 6. Neurogenic causes of urinary incontinence, Problems in neurology, Wobbler syndrome,

Neuroimaging, Golden retriever myopathy, Feline brain diseases. World Small Animal Veterinary Association. Harrogate, ENGLAND (1989).

5. Intracranial surgery, Canine muscle diseases, Neuroimaging, Anticonvulsant therapy.

Neurology Study Group of the French Small Animal Assn. Paris, FRANCE (1989). 4. Neurology core (with RA LeCouteur). 2nd Pan-Asian Small Animal Veterinary

Conference. Sponsored by the Australian Small Animal Veterinary Association. HONG KONG (1989).

3. Small animal neurology. Malaysian Veterinary Association (sponsored by Nestlé). Kuala

Lumpur, MALAYSIA (1986). 2. Neurologic lesion localization, Neurosurgery wet lab. New Zealand Veterinary

Association (Special Course). Auckland, NEW ZEALAND (1986). 1. Neurologic lesion localization, Problems in neurology. New Zealand Veterinary

Association (Small Animal Program). Auckland, NEW ZEALAND (1986). Advisory Activities Undergraduate student laboratory rotations Taylor Gourley, Texas A&M (2016-2018) Alexander Vidal, Texas A&M (2016-2018) Madison Rigsby, Texas A&M (2016-2018) Briana Hernandez, Texas A&M (2016) Katherine Hulbert, Texas A&M (2016-2018))

Curriculum Vitae Joe N. Kornegay, DVM, PhD Jason Wey, Texas A&M (2015-2016) Yasemin Clelan, Texas A&M (2015) Adam Bates, Texas A&M (2014) Kristina Kalevas, UNC-CH (2008-2009) Brittany Enders, UNC-CH (2007-2008) Robert Tomazic, UNC-CH (2007) Professional student laboratory rotations Jessica Smith, Texas A&M veterinary student, Merial Summer Research Program (2016) Juan M. Diaz, Texas A&M veterinary student, Merial Summer Research Program (2014) Kristin Bailey, Texas A&M veterinary student, Merial Summer Research Program (2013) Raymond Esparza, Texas A&M veterinary student, Merial Summer Research Program (2013) Susan Britt, NCSU veterinary student (2009) Resident research laboratory rotations (Texas A&M University) Sarah Schneider (2012-2013) Undergraduate students (Pre-Veterinary Scholars Program; Missouri) Laura Koenigsdorf (1996-1999; DVM, 2003) Allison Judd (1994-1997; DVM, 2001) Residents Justin C. DeVanna, Small Animal Internal Medicine (2010-1013) Jolie Jarboe, Neurology (1996-1999) Randy Longshore, Neurology (1994-1996) Ronald Schueler, Neurology (1992-1994) (Chair) Alistair McVey, Neurology (1992-1994) (Chair) Laurent Cauzinille, Neurology (1990-1993) (Chair) Rod Bagley, Neurology (1989-1992) Scott Plummer, Neurology (1989-1992) (Chair) Heather Jans, Internal Medicine (1987-1989) Stephen Lane, Neurology (1986-1989) (Chair) Christine Thomson, Neurology (1985-1988) (Chair) Postdoctoral Students Sharla M. Birch, Postdoctoral fellow (2016-2018) Emiko Van Wie, Postdoctoral fellow (2013-14) Eric R. Snook, Postdoctoral fellow (2013-14) Ligia Gomes Miyazato, Postdoctoral fellow (visitor from Brazil) (2009) Jocelyn Liu, Postdoctoral fellow (2001-2003) Martin (Casey) Childers, Postdoctoral fellow (1998-1999)

Curriculum Vitae Joe N. Kornegay, DVM, PhD Carolyn Okamura, Postdoctoral fellow (1997-2003) Diane Cundiff, Research associate (1994-1997) William Thomas, Neurology instructor (1991-1993) Keiko Nakagaki, Research associate (1989-1993) Andy Hopkins, Neurology instructor (1989-1991) Larry Gainsburg, Neurology fellow (1986-1988) Nicholas Sharp, Neurology instructor (1986-1988) (1992 Graduate Students Current 2. Matthew Wilcox, PhD Candidate (Texas A&M University), Graduate Committee 1. Sara Mata, PhD Candidate (Texas A&M University), Co-Major Professor Former 23. Lee-Jae (Jack) Guo, PhD (Texas A&M University, 2019 [expected, December

graduation]), Major Professor (Co-Chair with PP Nghiem upon retirement, June 1, 2019). Dissertation: Cardiomyopathy in the golden retriever model of Duchenne muscular dystrophy.

22. Seth Gregory Haddix, PhD (Texas A&M University, 2019 [expected, December

graduation]), Graduate Committee. Dissertation: Mammalian models of Duchenne muscular dystrophy: An investigation on the neuromuscular junction and cardiac functionality.

21. Sarah M. Schneider, PhD (Texas A&M University, 2019), Major Professor. Dissertation:

Cardiomyopathy in the golden retriever model of Duchenne muscular dystrophy: Phenotype, gene expression, and metabolic studies.

20. Aydin Eresen, PhD (Texas A&M University, 2018), Graduate Committee. Dissertation:

Detection of MRI biomarkers of golden retriever Duchenne muscular dystrophy. 19. Kurt A. Parizak, MS (Texas A&M University 2017), Graduate Committee. Thesis:

Integrating external hardware on existing magnetic resonance systems for commercially unsupported applications.

18. Sharla M. Birch, PhD (Texas A&M University, 2016), Major Professor. Dissertation:

Advanced imaging of disease: fetal alcohol spectrum and Duchenne muscular dystrophy. 17. W. Benjamin Stoughton, PhD (Texas A&M University, 2016), Major Professor.

Dissertation: Skeletal muscle homeostasis in golden retriever muscular dystrophy: The role of apoptosis and autophagy in GRMD pathogenesis.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 16. Jessica Hokamp, PhD (Texas A&M University, 2016), Graduate Committee.

Dissertation: Characterization and comparison of urine and serum proteins with renal biopsy findings and clinical data in dogs with naturally occurring proteinuric renal disease.

15. Stephen McConnell, MS (Texas A&M University, 2016), Graduate Committee. Automatic canine muscle histology image segmentation based on RGB histogram. 14. Mary Jane E. Schneck, Non-thesis Masters (Texas A&M University, 2016), Major

Professor. 13. Austin Acosta, Non-thesis Masters (Texas A&M University, 2016), Major Professor. 12. Mallory (Scola) Selzo, PhD (University of North Carolina/NC State University Joint

Department of Biomedical Engineering, 2014), Graduate Committee. Dissertation: Interrogating the viscoelastic properties of tissue using viscoelastic response (VisR) ultrasound.

11. Amber Playle, MS (Texas A&M University, 2014), Graduate Committee. Thesis: Gait

synthesis of abnormal gaits in canines. 10. Kristine Wadosky, PhD (University of North Carolina-Chapel Hill, 2014), Graduate

Committee. Dissertation: Cardiac muscle ring finger 1 inhibits adaptive hypertrophic remodeling induced by IGF-1, exercise, and thyroid hormone.

9. Peter P. Nghiem, PhD (George Washington University, Washington, DC, 2013), Co-

Major Professor; Reader. Dissertation: Molecular basis of paradoxical muscle hypertrophy in dystrophin-deficient muscle.

8. Nicholas Dobes, PhD (University of North Carolina-Chapel Hill, 2013), Graduate

Committee; Reader. Dissertation: The isolation of primary canine satellite cells utilizing microarray technologies. 7. Justin DeVanna, MS (non-thesis) (NC State University, 2013), Graduate Committee. 6. David A. Detwiler, PhD (University of North Carolina-Chapel Hill, 2012), Major

Professor. Dissertation: Isolation of primary canine satellite cells. 5 Bo He, PhD (University of North Carolina-Chapel Hill, 2011), Graduate Committee.

Dissertation: Gene delivery of MG53 for muscle membrane repair attenuates congestive heart failure and muscular dystrophy.

4. Martin K. Childers, PhD (University of Missouri-Columbia, 2002), Graduate Committee.

Dissertation: Contraction-induced muscle damage.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 3. Scott J. Schatzberg, PhD (North Carolina State University, 1998), Graduate Committee.

Dissertation: Molecular studies of the canine dystrophin gene. 2. Susan M. Prattis, PhD (North Carolina State University, 1992), Major Professor.

Dissertation: Expression of neural cell adhesion molecule in animal models of X-linked muscular dystrophy.

1. Nicholas JH. Sharp, PhD (Duke University, 1991), Graduate Committee. Dissertation:

The molecular basis of dystrophin deficiency in golden retriever muscular dystrophy, the canine homologue of Duchenne muscular dystrophy.

Faculty (mentorship committees) Gwen Levine, DVM Texas A&M (2013-present) Tracy Heenan, DVM, UNC-CH (2007-2102) Judith Nielsen, DVM, UNC-CH (2008-2102) GRANTS Research Supported as Principal Investigator Current Pending Prior 60. Application of an immortalized canine muscle line and SIAC to muscular dystrophy

studies. Solid GT (Gene Therapy). JN Kornegay, Principal Investigator; 2% effort; 02/1/2018-09/30/2019; $100,340 Total; $83,616 Direct. (Transferred to Peter P. Nghiem, DVM, PhD May 31, 2019).

59. Safety and efficacy of systemic gene therapy in informative models for DMD. NIH

(NINDS) (1 R01NS094705-01). HH Stedman, Principal Investigator, University of Pennsylvania; JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; 12/1/2015-11/30/2020; $890,910 Total; $567,343 Direct. (Transferred to Peter P. Nghiem, DVM, PhD May 31, 2019).

58. Glycosyltransferase therapies for myopathies. NIH (NIAMS) (R01 AR049722). PT

Martin, Principal Investigator, Nationwide Children’s Hospital and Ohio State University, Columbus, OH. JN Kornegay, Principal Investigator on the Texas A&M subcontract; 10% effort; 8/1/2016-7/31/2019; $622,737 Total; $444,248 Direct (GRMD studies begin in Year 3 of the parent grant). (Transferred to Peter P. Nghiem, DVM, PhD May 31, 2019).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 57. Derivation of muscle progenitors from hPSCs to transplant in a dog model of DMD.

Foundation Grant from Southwest National Primate Research Center, Texas Biomedical Research Institute; JN Kornegay, Principal Investigator. 5% effort; 04/01/2016-03/31/2019 (reflects extension); $90,000 Total; $90,000 Direct.

56. Laminin protein therapy for congenital muscular dystrophy. NIH (NIAMS)

(1R01AR064338-01A1) DJ Burkin, Principal Investigator, University of Nevada-Reno. JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 5% effort; 04/1/2018-03/31/2019 (Year 4 of parent grant); $54,567 Total; $36,746 Direct.

55. Natural history of muscular dystrophy phenotypic biomarkers in normal dogs. Solid

Biosciences. JN Kornegay, Principal Investigator, 10% effort; 05/01/17-04/30/2019; $194,870 Total; $162,392 Direct.

54. Image and histopathologic assessment of GRMD dogs treated with AAV-

microdystrophin constructs (salary and benefits for Associate Research Scientist position for Dr. Sharla Birch; extension of prior fellowship grant). Solid GT. 07/01/17-12/31/18; $175,762 Total; $146,468 Direct. Dr. Birch accepted another position and resigned her TAMU position effective 4/30/18. At that time, there was $131,980 direct and $26,396 indirect ($158,376 total) in the account. Of this amount, $32,000 will be gifted to TAMU, with the remainder returned to Solid.

53. Assessment of safety/biodistribution/efficacy of IV AAV-micro-dystrophin construct

using GRMD dogs. Solid GT. JN Kornegay, Principal Investigator, 10% effort; 09/01/2015-08/31/2018; $521,488 Total; $441,150 Direct. (These funds were expended as of ~ 07/01/17; for sake of overages, Solid provided supplemental support of $238,250.25 Direct on 11-08-17).

52. Development of a porcine model of Duchenne muscular dystrophy. NIH (NIAMS)

(2R44AR061900-02A1). C Rogers, Principal Investigator, Exemplar Genetics, Coralville, IA. Subcontract to Texas A&M University; JN Kornegay, Principal Investigator on the Texas A&M subcontract; 10% effort; 12/01/13-11/30/15; $547,196 Total; $406,511 Direct. (No cost extension to March 31, 2018; these funds have not been utilized because Exemplar Genetics have not been able to produce the affected pigs).

51. Cardiomyopathy in the golden retriever model of muscular dystrophy. Morris Animal

Foundation. Fellowship for Dr. Sarah Schneider. 01/01/14-12/31/17; $160,000 Total; $147,200 Direct.

50. Image and histopathologic assessment of GRMD dogs treated with AAV-

microdystrophin constructs. Solid GT. Fellowship for Dr. Sharla Birch. 10/01/15-09/31/17; $179,010 Total; $149,237 Direct.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 49. Advanced gene therapy for treatment of cardiomyopathy and respiratory insufficiency in

Duchenne muscular dystrophy. US Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP), Duchenne Muscular Dystrophy Research Program (DMDRP) Investigator-Initiated Research Award (MD120087). BJ Byrne, Principal Investigator, University of Florida; JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; 07/01/14-08/14/17; $348,640 Total; $238,794 Direct.

48. MG53 as a therapeutic protein for treatment of muscular dystrophy. NIH-NIND

(S2R44AG060019-02). Cooperative Program in Translational Research Small Business Awards (SBIR [U44]). Norio Takizawa, TRIM-edicine; Subcontract to Texas A&M; JN Kornegay, Principal Investigator on the Texas A&M subcontract; 10% effort; 012/15/13–12/14/15; $419,315 Total; $288,189 Direct.

47. DP ARF ultrasound for monitoring muscle degeneration in Duchenne muscular

dystrophy. NIH-NIAMS (1R01NS074057-01A1). Gallippi CM, Principal Investigator; University of North Carolina-Chapel Hill; JN Kornegay, Co-Investigator; 10% effort; 10/01/11–09/31/16; $2,321,573 Total; $1,486,613 Direct. Subcontract to Texas A&M University (Yrs. 2-5); JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; 09/01/12-08/31/16; $547,061 Total; $374,699 Direct.

46. Laminin-111 protein therapy for Duchenne muscular dystrophy. Muscular Dystrophy

Association. Burkin DJ , Principal Investigator, University of Nevada-Reno; Subcontract to Texas A&M University; JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 5% effort (no salary per MDA guidelines); 08/01/12-07/31/15 (A&M Yrs 2 and 3); $112,617 Total; $102,379 Direct.

45. Myostatin inhibition in DMD dogs by gene transfer. NIH (NIAMS) (1 R01AR056394-

01A2). Xiao Xiao, Principal Investigator, University of North Carolina-Chapel Hill; JN Kornegay, Co-Investigator; 5% effort; 07/01/09–6/30/13; $1,843,750 Total; $1,250,000 Direct. Subcontract to Texas A&M University (Yr. 5); JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 5% effort; 07/01/13-06/30/14; $39,608 Total; $25,325 Direct.

44. Systemic molecular therapy for muscular dystrophy. NIH (NINDS) (R01NS042874).

HH Stedman, Principal Investigator, University of Pennsylvania. Subcontract to the University of North Carolina–Chapel Hill (Yrs. 1-3); JN Kornegay, Principal Investigator on the UNC-CH subcontract; 10% effort; 04/01/2009-3/31/2012; $569,728 Total; $381,331 Direct. Subcontract to Texas A&M University (Yrs. 4 and 5); JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; 09/01/12-08/31/14; $319,088 Total; $218,544 Direct.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 43. NF-kB Inhibition therapy for Duchenne muscular dystrophy, NIH (NINDS)

(1U01NS058451-01A1). DE Guttridge, Principal Investigator, Ohio State University. Subcontract to the University of North Carolina–Chapel Hill (Yrs 3 and 4); JN Kornegay, Principal Investigator on the University of North Carolina-Chapel Hill subcontract; 20% effort; 10/01/09-09/30/12; $473,783 Total; $316,912 Direct. Subcontract to Texas A&M University (Yr.5, pending); JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; $45,978 Total; $31,384 Direct.

42. Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (U-54). NIH (NIAMS) (1U54AR056953-01). RJ Samulski, Principal Investigator, University of

North Carolina at Chapel Hill; JN Kornegay, Principal Investigator on Core C, National Canine Muscular Dystrophy Core (NCMDC) and Co-Investigator on Project 2, Gene Therapy in the Golden Retriever Muscular Dystrophy Model; 20% effort (no salary; covered through the U-24); 07/01/08–06-30-13; Budget for Core C: Total $1,110,989; $836,279 Direct; Requested from NIH: $274,710 Direct (other funds covered through the U-24 and/or donors). Subcontract to Texas A&M University; JN Kornegay, Principal Investigator on the Texas A&M University subcontract; 10% effort; 09/01/12-08/31/13; $83,848 Total; $57,430 Direct.

41. Natural history and immunologic parameters in the GSHPMD dog. Muscular Dystrophy

Association Infrastructure Grant to the Translational Research Advisory Committee (TRAC). JN Kornegay, Principal Investigator; 8% effort; 01/01/09 - 12/31/11; $884,422 Total; $804,422 Direct.

40. Chemically-based membrane sealants for dystrophic muscle. NIH (NHLBI) (R01-

HL086790-02). JM Metzger, Principal Investigator, University of Minnesota. Subcontract to the University of North Carolina–Chapel Hill; JN Kornegay, Principal Investigator on the UNC-CH subcontract; 5% effort; 07/01/08–06/30/11; $167,392 Total; $113,486 Direct.

39. Co-operative Program in Translational Research: Establishment of the National Center

for Canine Models of Duchenne Muscular Dystrophy (NCDMD). NIH (NINDS/NIAMS) (1U24NS059696-01A1). JN Kornegay, Principal Investigator; 50% effort; 05/01/08–04/31/13; Total $5,258,622; $3,758,622 Direct. (Note, this was a milestone-driven grant; milestones for Yr 2 were not met so subsequent funding was not provided).

38. Preclinical studies in the GRMD model. Association Monegasque contre les Myopathies.

JN Kornegay, Principal Investigator. 04/01/2010 - 03/31/2011; $64,730 Total; $58,845 Direct.

37. ARRA supplement to Co-operative Program in Translational Research: Proposal for

Establishment of the National Center for Canine Models of Duchenne Muscular Dystrophy (NCDMD). NIH (NINDS/NIAMS) (3U24NS059696-01A1S1). Purchase of an imaging system for acoustic radiation force impulse (ARFI) imaging (equipment supplement); JN Kornegay, Principal Investigator; 2009; $95,000 (Total and Direct).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 36. Supplement to Co-operative Program in Translational Research: Proposal for

Establishment of the National Center for Canine Models of Duchenne Muscular Dystrophy (NCDMD). NIH (NINDS/NIAMS) (1U24NS059696-01A1). Jacketed external telemetry (JET) for monitoring of respiratory function in GRMD (equipment supplement); JN Kornegay, Principal Investigator; 2009; $41,250 (Total and Direct).

35. Translational Program for Molecular therapeutics in Duchenne Muscular Dystrophy.

National Institutes of Health (NINDS), Cooperative Program in Translational Research (1U01NS052476). HH Stedman, Principal Investigator, University of Pennsylvania. Subcontract to the University of North Carolina-Chapel Hill; JN Kornegay, Principal Investigator on the UNC-CH subcontract; 15% effort; 09/01/07–08/31/09; $404,316 Total; $276,929 Direct.

34. Expression profiling in golden retriever muscular dystrophy. Core support from

Integrated Molecular Core for Rehabilitation Medicine (R24HDO50846; Hoffman EP, Principal Investigator); National Institute of Child Health and Human Development (National Center for Medical Rehabilitation Research). 09/01/08-08/31/09; $24,000 Total; $24,000 Direct.

33. Local injection of the intron 60-trans-splicing AAV vectors in dystrophic dog. D Duan,

Principal Investigator, University of Missouri. Subcontract to the University of North Carolina-Chapel Hill; JN Kornegay, Principal Investigator on the University of North Carolina-Chapel Hill subcontract; 5% effort (no salary support, per MDA guidelines); 01/01/08-12/31/09; $96,914 Total; $88,104 Direct.

32. Myostatin inhibition in a dog model of DMD, National Institutes of Health (NIAMS;

Collaborative Project Funds). HL Sweeney, Principal Investigator, University of Pennsylvania. Subcontract to the University of North Carolina–Chapel Hill; JN Kornegay, Principal Investigator on the UNC-CH subcontract; 5% effort; 09/01/07–08/31/08; $81,643 Total ($55,920 Direct).

31. NIH NIAMS RFA-AR-03-001 (Golorioso, JC; PI); Gene and cell therapy of Duchenne

muscular dystrophy. Subcontract to the University of North Carolina-Chapel Hill. JN Kornegay, Director, Golden Retriever Muscular Dystrophy Animal Core; 12% effort (no salary support); 06/01/07 – 05/31/08; $130,558 Total ($89,423 Direct).

30. MDA bridging funds to support GRMD dog studies at UNC. Muscular Dystrophy

Association. JN Kornegay, Principal Investigator; 03/01/07–2/28/08; Total $187,000 ($170,000 Direct).

29. Investigative therapeutics in a canine model of Duchenne muscular dystrophy. Parent

Project for Duchenne Muscular Dystrophy; 01/01/2005 – 07/31/2006; $135,958 Total ($123,598 Direct).

28. Cellular effects of prednisone treatment in canine dystrophy. Muscular Dystrophy

Association; 2001-2003; $223,603 (with CS Okamura and MK Childers).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 27. Investigative therapeutics in a canine model of Duchenne Muscular Dystrophy. Parent

Project for Muscular Dystrophy; 2001-2003; $287,269 (with CS Okamura). 26. Cellular effects of prednisone treatment in canine dystrophy. Association Francaise

Contre les Myopathies (Muscular Dystrophy Association of France); 2001-2003; $71,604 (with CS Okamura and MK Childers).

25. Factors contributing to cranial sartorius muscle regeneration in GRMD. Fellowship for

Dr. Martin K. Childers. Parent Project for Muscular Dystrophy Research (through the Duchenne Muscular Dystrophy Center, University of Pittsburgh, Pittsburgh, PA); 1998-1999; $69,160 (salary and benefits).

24. Utrophin in a canine model of Duchenne muscular dystrophy. Association Francaise

contre les myopathies (Muscular Dystrophy Association of France) ; 1998-1999; $116,666 (with EP Hoffman and C Angelini).


Project for Muscular Dystrophy Research (through the Duchenne Muscular Dystrophy Center, University of Pittsburgh, Pittsburgh, PA); 1998-1999; $82,000.

22. Utrophin in a canine model of Duchenne muscular dystrophy. Muscular Dystrophy

Association; 1998; $50,000 (with EP Hoffman and C Angelini). 21. Investigative therapeutics in a canine model of Duchenne muscular dystrophy. Parent


20. Hemin treatment of the canine model of Duchenne muscular dystrophy. Nemours

Foundation (through the Alfred I. duPont Institute, Wilmington, DE); 1996-1998; $80,564.

19. Vascular hypoperfusion causes phenotypic variation in GRMD. Muscular Dystrophy

Association; 1995-1998; $150,000 (with MH Laughlin, MK Childers, JL Tomlinson, DD Cundiff).



17. Natural history and myoblast transplantation in a model of DMD. Muscular Dystrophy

Association; 1992-1995; $252,605 (with EV DeBuysscher, Y Azuma, SD Van Camp, RJ Bartlett, MJ Dykstra, DH Gebhard, SM Prattis, NJH Sharp, MC Reedy).

16. Studies of golden retriever muscular dystrophy in developmental therapeutics. Hoechst

AG, Werk Kalle-Albert (Germany); 1992-1995; $374,000.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 15. Natural history and myoblast transplantation in a model of DMD. Muscular Dystrophy

Association; 1992; $43,120 (with EV DeBuysscher, Y Azuma, SD Van Camp, RJ Bartlett, MJ Dykstra, DH Gebhard, SM Prattis, NJH Sharp, MC Reedy).

14. Characterization of myoblast transplant immunorejection and its prevention in canine

muscle injured with notexin. North Carolina State University College of Veterinary Medicine State Research Support Grants Program; 1991-1992; $24,079 (with EV DeBuysscher, Y Azuma, SD Van Camp, RJ Bartlett, MJ Dykstra, DH Gebhard, SM Prattis, NJH Sharp).

13. Myoblast transplantation in golden retriever muscular dystrophy. The Carrie E. and Lena

V. Glenn Foundation; 1991-1992; $10,000 (with EV DeBuysscher, Y Azuma, SD Van Camp, RJ Bartlett, MJ Dykstra, DH Gebhard, SM Prattis, NJH Sharp).

12. Studies of HWA 468 in spontaneous and experimental forms of canine muscle disease.

Hoechst AG, Werk Kalle-Albert (HWK-A); 1990-1992; $60,488. 11. Transplantation studies of canine and murine models of Duchenne muscular dystrophy.

Association Francaise Contre les Myopathies (Muscular Dystrophy Association of France); 1989-1992; $74,852 (with R Bartlett, N Sharp).

10. Muscle regeneration after localized and systemic myoblast transplantation in X-

irradiated, notexin-injured canine muscle. North Carolina State University College of Veterinary Medicine State Research Support Grants Program; 1990-1991; $24,140 (with S Prattis, M Dykstra, NJH Sharp, W Hung, H Alameddine).

9. Transplantation therapy in canine and murine DMD models. Muscular Dystrophy

Association; 1989-1991; $93,000 (with R Bartlett, N Sharp, W Hung, S Lane, T Burt). 8. Golden retriever muscular dystrophy: Degree of fiber mineralization and dystrophin

localization. North Carolina State University College of Veterinary Medicine State Research Support; 1988-1990; $23,274 (with M Dykstra, N Sharp, S Lane).

7. Systemic myoblast and bone marrow transplantation in canine and murine Duchenne

muscular dystrophy. March of Dimes Birth Defects Foundation; 1988-1990; $60,000 (with N Sharp, R Bartlett, S Van Camp, W Hung, K Nakagaki).

6. Molecular analysis of golden retriever myopathy: A model for Duchenne muscular

dystrophy. I. Colony support and phenotypic studies. North Carolina Biotechnology Center; 1988-1989; $18,987 (with S Lane, N Sharp, S Van Camp).

5. Transient paralysis in North Carolina broilers: definition of responsible lesions(s) and

agent(s). Southeastern Poultry and Egg Association; 1988-1989; $34,000 (with D Wages, J Guy, S Smittle).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 4. Electrophysiologic and histopathologic evaluation of the ototoxic and neuropathic effects

of cis-dichlorodiamineplatinum II, North Carolina State University School of Veterinary Medicine State Research Support; 1986-1987; $6,720 (with C Thomson, R Page, D Thrall).

3. Marek's disease virus-induced transient paralysis, North Carolina State University School

of Veterinary Medicine State Research Support; 1985-1986; $11,100 (with L Hudson, D Simmons).

2. Marek's disease virus induced transient paralysis, North Carolina State University School

of Veterinary Medicine State Research Support; 1984-1985; $24,400 (with L Hudson, D Simmons).

1. Investigation of canine myopathies. North Carolina Veterinary Medical Foundation;

1983-1984; $5,514 (with R Easley). Research Supported as Co-Investigator Current Pending Prior 22. Proprietary myosin inhibitors in canine muscular dystrophy. Edgewise Therapeutics, PP

Nghiem, Principal Investigator. JN Kornegay, Collaborator; 0% effort; 09/30/18-09/29/19. $54,229 Total; $36,518 Direct.

21. DP ARF ultrasound for monitoring muscle degeneration in Duchenne muscular

dystrophy. NIH (1R01NS074057-01A1). Gallippi CM, Principal Investigator; JN Kornegay, Co-Investigator; 10% effort; 10/01/11–09/31/16; $2,321,573 Total; $1,486,613 Direct. (Grant transferred to Texas A&M University, 2012; JN Kornegay, Principal Investigator on the Texas A&M University Subcontract).

20. Myostatin inhibition in DMD dogs by gene transfer. NIH (NIAMS) (1R01AR056394-

01A2). Xiao Xiao, Principal Investigator; JN Kornegay, Co-Investigator; 5% effort; 07/01/09–6/30/13; $1,843,750 Total; $1,250,000 Direct. (Grant transferred to Texas A&M University, 2012; JN Kornegay, Principal Investigator on the Texas A&M University Subcontract).

19. Automated atlas-based muscle MRI quantification in Duchenne muscular dystrophy

patients. North Carolina Translational and Clinical Sciences Institute (NC TraCS) (# 50KR71104). Fan, Z (PI) Principal Investigator; JN Kornegay, Co-Investigator; 07/01/11-06/30/12; $49,664 Total and Direct.

Curriculum Vitae Joe N. Kornegay, DVM, PhD 18. Characterization of brain white matter development using high resolution magnetic

resonance diffusion tensor imaging with histologic confirmation. North Carolina Translational and Clinical Sciences Institute (NC TraCS) (# 50KR51003). An H, Principal Investigator; JN Kornegay, Co-Investigator; 01/01/11-12/31/11; $50,000 Total and Direct.

17. Leupeptin in a canine model of Duchenne muscular dystrophy. NIH (NINDS) (R-21);

2005-2007; Total $367,500 ($250,000 Direct). (MK Childers, Principal Investigator). 16. Use of a novel calpain inhibitor, C101, in canine muscular dystrophy. Ceptor, Inc.; 2004- 2005; $200,000 ($141,275 direct). (MK Childers, Principal Investigator). 15. Muscle fiber survival and function in a canine model of Duchenne muscular dystrophy.

Muscular Dystrophy Association (Research Development Grant for MK Childers, DO; JN Kornegay, sponsor); 2001-2003; $105,000 (with K McDonald).

14. Muscle response to stress in a canine muscular dystrophy model. NIH (NICHD). KO8

Mentored Clinical Scientist Development Award for Martin K. Childers; 1999-2002; $334,800 (I served as Dr. Childers’ mentor on this award).

13. Mechanical properties of dystrophic myofibers. MU Research Board (instrumentation

grant); 2000; $15,598. MK Childers, Principal Investigator). 12. Can dystrophin alternate transcripts be used to treat DMD? Muscular Dystrophy

Association; 1997-2000; $150,000 (NJH Sharp, Principal Investigator). 11. Missouri Rehabilitation Research Training Program. NIH (Child Health and Human

Development); 1994-1999, $889,694 (SP Buckelew, Principal Investigator). 10. Use of a canine model to quantify how location of botulinum toxin injection affects

muscle paralysis. Allergan, Inc; 1995-1996; $27,600 (MK Childers, Principal Investigator).

9. Gene therapy in muscular dystrophy. Muscular Dystrophy Association; 1992-1995;

$279,085 (R Bartlett, Principal Investigator). 8. Comparative oncology research program. National Institutes of Health. Consortium

between Colorado State University, North Carolina State University, and Duke University; 1990-1995, $9,975,266 (EL Gillette, Principal Investigator).

7. Ultrastructure of myoblast transplantation in canine DMD. Muscular Dystrophy

Association; 1991-1994; $113,346. (M Reedy, Principal Investigator). 6. Protein expression in regenerating canine muscle. Muscular Dystrophy Group of Britain;

1990-1992; $17,000 (J Harris, Principal Investigator).

Curriculum Vitae Joe N. Kornegay, DVM, PhD 5. Investigations into the peripheral neuropathy of Marek's disease in chickens. College of

Veterinary Medicine State Research Support; 1990-1991; $19,072 (S Wheeler, Principal Investigator).

4. A study of the chemotactic properties of platelet-derived growth factor (PDGF) on canine

skeletal myoblasts. College of Veterinary Medicine State Research Support; 1990-1991; $4,633 (P Sannes, Principal Investigator).

3. Herpesvirus-induced transient paralysis in chickens. National Institutes of Health; 1980-

l982; $128,530 (L Schierman, Principal Investigator). 2. Dysmyelination in chow-chow dogs. Veterinary Medical Experiment Station, University

of Georgia; 1980-l981; $4,000 (E Gorgacz, Principal Investigator). 1. Herpesvirus-induced transient paralysis in chickens. Veterinary Medical Experiment

Station, University of Georgia; 1980-1981; $3,165 (E Gorgacz, Principal Investigator). PROFESSIONAL SERVICE Professional licenses, board certification Veterinary Board Licensure (States) Texas (3430) 1973-1986; 2013-present North Carolina (6228) 2007-2014 (FC-04182) 1982-1993 Missouri (VT 0R5930) 1994-2007 Georgia (FC-36) 1976-1982 Ohio (3554) 1973-1974 Specialty Board Certification American College of Veterinary Internal Medicine (Specialty of Neurology) (1980) American College of Veterinary Pathologists (Honorary) (2017) Memberships Association for Assessment and Accreditation of Laboratory Animal Care International

(AAALAC); Liaison from AAVMC (2018-2020). American Veterinary Medical Association (1973-present) American College of Veterinary Internal Medicine (1980-present) Board of Regents (1993-1996) (2012-2017) Past Chair (2016-2017) Chair (2015-2016) President (2014-2015) President Elect (2013-2014) Vice President (2012-2013) President, Specialty of Neurology (1993-1996)

Curriculum Vitae Joe N. Kornegay, DVM, PhD Credentials Committee (1992-1994) Constitution Committee (1991-1994) Standard Nomenclature Committee (1991-1993; Chair1991-1993) Neurology Program Chair (1988) Program Committee, Annual Forum (1987-1988) Certifying Examination Committee (Neurology) (1983-1985; Chair, 1985) Nominations Committee (1983-84) North Carolina Veterinary Medical Association (1983-1993; 2007-2013) The American Society of Gene Therapy (1997-2000; 2007-2014) American Royal Advisory Directors (Business and Industry) (2005-2006) Mid-Continent Association for Agriculture, Biomedical Research and Education (MAABRE)

Board of Directors (2004-2006) Missouri Innovation Center (Board) (2003-2006) Association of American Veterinary Medical Colleges (1998-2006) Board of Directors (Secretary) (2001-2002) (2006) Joint AVMA/AAVMC Task Force on Veterinary Infrastructure in Iraq and Afghanistan (Co-Chair) (2005) International Affairs Committee (Chair) (2005-2006) Liaison, Association for Assessment and Accreditation of Laboratory Animal Care

International (AAALAC) (2018-2020). Boone County - Columbia (Missouri) Area Veterinary Medical Association (1994-1998) West Central (Missouri) Veterinary Medical Association (1994-2006) Missouri Veterinary Medical Association (1994-2006) Executive Board, Ex-Officio Member (1998-2006) American Association of Veterinary Clinicians (1994-1998) Awards Committee (Chair) (1997-1998) Sigma Xi - The Scientific Research Society; Full Membership (1982-1994) American Association for the Advancement of Science (1982-2010) Triangle (North Carolina) Veterinary Medical Association (1982-1993) Texas Veterinary Medical Association (1974-1976) Harris County (Texas) Veterinary Medical Association (1974-1976) Executive Committee (1975-l976) Ohio Veterinary Medical Association (1973-1974) Editorial Review Boards Muscle and Nerve, Editorial Board (2016-present ) Editorial Advisory Board, Progress in Veterinary Neurology (1989-1994) Neurology Editor, Journal of Veterinary Internal Medicine (1988-1992) Neurologic Diseases, Section Editor, Current Veterinary Therapy X and XI RW Kirk and JD Bonagura (eds). WB Saunders Co, Philadelphia (1989, 1992) Reviewer, Chapters on Introduction to the Nervous System and Principles of Therapy Merck Veterinary Manual (1985, 1989) Ad hoc reviewer - Journal of the American Veterinary Medical Association, Journal of the American Animal Hospital Association, Journal of Cellular and Molecular Medicine,

Journal of Neurological Sciences, Journal of Veterinary Internal Medicine, Muscle


Nerve, Neuromuscular Disorders, Journal of Veterinary Radiology and Ultrasound, Human Molecular Genetics, American Journal of Pathology, Journal of Visualized Experiments, Journal of Veterinary Pharmacology and Therapeutics, Veterinary Pathology, Animal Genetics, Cell Transplantation, Journal of Neuromuscular Diseases

Advisory Comparative Biomedical Scientist Training Program, National Cancer Institute (NCI), External

Advisory Board (Chair) (2018-present) External Examiner External Examiner and Assessor of Curriculum and Internalization of DVM Programme

Universiti Putra Malaysia Faculty of Veterinary Medicine (3-year commitment, 2001-03) Consultantships Solid Biosciences, Cambridge, MA (2015-present) Charles River Laboratories, Spencerville, OH (2007) Glaxo Inc, Research Triangle Park, NC (1992-1993) Merck Sharpe and Dohme Research Laboratories, Division of Merck and Co, Inc, West Point,

PA (1992-1993; 1998-2002) Norwich Eaton Pharmaceuticals, Inc, Norwich, NY (1987-1993) NIH Study Sections (2007-present) National Center for Advancing Translational Sciences (NCATS) Special Emphasis Panel.

CTSA Collaborative Innovation U01 and R21 Award Review, September 25 (2019) CTSA Collaborative Innovation U01 and R21 Award Review, February 22, 23 (2018) CTSA Collaborative Innovation U01 and R21 Award Review, June 28 (2017)

National Institute of Neurological Disorders and Stroke (NINDS) Special Emphasis Panel on Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MRSRCs) (P50) (March 27, 28, 2018) (withdrew due to personal medical issue)

National Heart, Lung, and Blood Institute – Ad hoc reviewer K99/R00 NIH Pathway to Independence Applications, October 14 (2010) K99/R00 NIH Pathway to Independence Applications, February 25 (2010) Skeletal Muscle and Exercise Physiology (SMEP) – Ad hoc reviewer Special Emphasis Panel/Scientific Review Group, October 9 (2008) Special Emphasis Panel/Scientific Review Group, October 11, 12 (2007) Special Emphasis Panel/Scientific Review Group, June 11, 12 (2007) Musculoskeletal Rehabilitation Sciences (MRS) Study Section – Ad hoc reviewer, Regular study section meeting, October 17 (2008) Musculoskeletal, Oral, and Skin Sciences (MOSS) Integrated Review Group – Ad hoc reviewer Special Emphasis Panel on Skeletal Muscle and Exercise Physiology, July 16 (2008)


National Institute for Musculoskeletal Diseases and Arthritis – Ad hoc reviewer NIAMS Core Center (P30) Applications, November 6, 7 (2008)

Other Grant Review Activities (2008-present)

Muscular Dystrophy Association Medical Advisory Committee (MDA-MAC/RAC/SAC) – Member (2010-present); Ad hoc reviewer (2010, 2011)

Duchenne UK (2019) National Science Center Poland (2019) American Kennel Club Canine Health Foundation (2019) The Netherlands Organisation for Scientific Research (NWO) (2019) Dutch Duchenne Parent Project (DPP/NL) – External Reviewer (2010, 2011, 2015, 2017) Jesse's Journey, The Foundation for Gene and Cell Therapy – External Reviewer (2008) Association Francaise contre les Myopathies (2011) Amyotrophic Lateral Sclerosis Society of Canada (2011)

Texas A&M University (2012-2019)

Ad hoc faculty group to develop Neuroscience major (2017-2019) Ad hoc faculty group to develop CVM Neuroscience white paper (Chair) (2017) Neuroscience-Muscular Dystrophy faculty search committee (Chair) (2015) Small Animal Clinical Sciences faculty search committee for internist (2015) Veterinary Integrative Biosciences Department Promotion and Tenure Committee (2013-2015) Texas A&M Institute for Neuroscience Seminar Committee (2013-2014) College of Veterinary Medicine Continuing Education Committee (2013-2017) Veterinary Anatomist faculty search committee (2013) Veterinary Pathobiology faculty search committee (2012) Ad hoc Committee to develop DVM curriculum elective for clinical research (2012-2013) Ad hoc Committee to study potential sites for new One Health Building (2012)

University of North Carolina-Chapel Hill Committees (2006-2012)

Department of Pathology and Laboratory Animal Medicine Grand Rounds Committee (2010-2012)

Department of Pathology and Laboratory Animal Medicine Research Advisory Committee (2010-2012)

Department of Pathology and Laboratory Animal Medicine Preliminary Exam Committee (2010-2012)

Division of Laboratory Animal Medicine (DLAM) Director search committee (Co-Chair) (2010- 2012)

Division of Laboratory Animal Medicine (DLAM) faculty position search committee (2009) Institutional Animal Care and Use Committee (IACUC) (2008-2012)


NCSU College of Veterinary Medicine and Campus-wide Committees (1982-1993; 2007-2014)

External Review Committee, Chair, Center for Comparative Medicine and Translational Research (CCMTR) (2008; 2014)

Department of Clinical Sciences Department Head Search Committee (2008) Neurologist Search Committee, Chair (1993) Graduate Student Admissions Committee (1991-1993) Curriculum Revision Task Force (1991-1993) Advisory Council for University Extension and Public Service (1990) Curriculum Committee (1988-1992; Chair, 1991-1992) CASS Department Head Search Committee (1988) University Extension, Lifelong Education and Instructional Television Committee (1987-1990) Committee on Continuing Education and Public Service (1987-1991; Chair, 1987-1991) Neurologist Search Committee, Chair (1985) Avian Clinician Search Committee (1984) Ophthalmologist Search Committee (1984) Admissions Committee (1984-86; Chair, 1986) Neurologist Search Committee, Chair (1984) Small Animal Surgeon Search Committee, Chair (1983) Service Chief (Medicine), Hospital Board (1983-84)

University of Missouri-Columbia College of Veterinary Medicine and Campus-wide Committees (1994-2006)

Led the State of Missouri Consortium to secure the Department of Homeland Security National Bio- and Agro-Defense Laboratory (NBAF) (2006)

Strategic Planning and Resource Advisory Committee: Subcommittee on the Pursuit of Quality, Innovation, Incentives, Risks and Rewards (2004-2006)

University of Missouri-Columbia Planning and Design Construction Advisory Council (2002- 2004; Chair 2003-2004)

University of Missouri-Columbia Healthcare Performance Improvement Steering Committee (2002)

University of Missouri System Graduate and Professional Fees Task Force (2002) University of Missouri-Columbia Hospital and Clinics Advisory Task Force (2002) Search Committee, School of Law Dean (2001) Search Committee, Vice Chancellor for Development (2001) Cancer Center Interim Co-Director (2001-2002) Life Sciences Task Force (2001-2006) Cancer Center Director Search Committee (Chair) (2000-2002) Cancer Center Internal Advisory Council (Chair) (2000-2002) Search Committee, School of Human Environmental Sciences Dean (2000) Missouri Veterinary Medical Association Executive Board (Ex-officio) (1998-2006) European Union Center Academic Cabinet (1998-2006) Dean’s Council (1998-2006)


Strategic Planning Advisory Council (special campus-wide committee appointed by the Chancellor) (1997-2002)

College of Veterinary Medicine Fund-raising Feasibility Task Force (1996) Promotion and Tenure Review Committee (Special campus-wide committee appointed by the

Provost) (1995-1996) Missouri Veterinary Medical Association Peer Review Committee (1995-1998) Dalton Cardiovascular Research Center Facilities Committee (1994-1998) Search Committee, Veterinary Pathobiology Department Chair (1994-1995) Search Committee, Animal Sciences Unit Leader (Chair) (1994-1995) Search Committee, Vice-Chancellor for Development and Alumni Relations (1994) College of Veterinary Medicine Executive Committee (1994-2006)

STATEMENT OF PROFESSIONAL EXPERIENCES AND EDUCATIONAL PHILOSOPHY

My professional career has included various experiences, ranging from private veterinary practice; to clinical residency and graduate training; to service as a faculty member with responsibilities across teaching, clinical care, and research; to administrative appointments as a department chair, hospital director, and dean; research facility director; and to positions focused primarily in research. These experiences have instilled a strong belief in the tripartite mission of public universities and the need to achieve synergy across our missions.

After graduation from the Texas A&M University College of Veterinary Medicine in 1973, I spent three years in private veterinary practice in Ohio and Texas, followed by six years in residency (separate neurology and pathology) and graduate (Masters and PhD) training at the University of Georgia College of Veterinary Medicine. Upon completion of my training at Georgia, I moved to the College of Veterinary Medicine at North Carolina State University where I served on the faculty for 11 years before moving to the College of Veterinary Medicine at the University of Missouri. At Missouri, I principally served as an administrator, first as a department chair and hospital director and later as dean. I was a faculty member in the School of Medicine at the University of North Carolina-Chapel Hill School of Medicine from 2006 to 2012, when I accepted joint appointments in the Departments of Veterinary Integrative Biosciences and Veterinary Pathobiology and the Interdisciplinary Neuroscience program at Texas A&M. Both the UNC and Texas A&M appointments principally involved research on a canine model of Duchenne muscular dystrophy. I served as Director of the Texas A&M Institute for Preclinical Studies (TIPS) from 2014-2016. The TIPS facility conducts preclinical studies, principally in large animal (dogs, pigs, sheep, calves) models, for biomedical device and drug development. Many of these studies are done on a contract basis with commercial companies and some are done utilizing good laboratory practices (GLP). I retired from Texas A&M June 1, 2019.

Teaching. As an educator, I have emphasized active learning, frequently incorporating case discussions into both didactic and laboratory sessions. Because of my dual training in clinical neurology/neurosurgery and neuropathology, I have tended to emphasize clinicopathologic correlation. My instructional career began at the University of Georgia College of Veterinary Medicine during my residency training. I interacted with veterinary students as they rotated


through clinical blocks in neurology and pathology. This principally entailed small group (rounds) discussions. Similarly, in my initial faculty appointment at the North Carolina State University College of Veterinary Medicine, I interacted with veterinary students on the neurology clinical rotation. At North Carolina State, I also taught in a range of both professional (DVM curriculum) and graduate didactic neurosciences courses, with emphasis on clinical neurology/neurosurgery and neuropathology. At both UNC-Chapel Hill and Texas A&M, I have been involved primarily in graduate education and courses.

Clinical Service. Through my three years in private clinical practice, I gained an appreciation for the key role that veterinarians play in primary care. Upon entering my residency training and later as a faculty member, I was an academic clinician, working with referring veterinarians and owners of animals with spontaneous neurologic diseases. I have training in both medical neurology and neurosurgery, so my practice entailed medical and surgical management. Most cases in my practice were seen on a referral basis, in general from a private practicing veterinarian but occasionally from other specialists in either private or academic practices. I have also consulted with anatomic pathologists on animals with neuropathologic or muscle lesions. My career as an academic clinician occurred in parallel with the emergence of trans-sectional imaging (computed tomography [CT] and magnetic resonance imaging [MRI]). I was involved in the early utilization of these techniques in spontaneous neurologic diseases and have continued to use imaging as an endpoint in my research on muscular dystrophy.

Research. I have conducted research on both experimental and spontaneous neurologic lesions/diseases. My Masters of Science degree dealt with the role of somatosensory evoked potentials in assessing the functional integrity of the spinal cord in dogs following experimental transection. Subsequently, I completed a PhD degree in which the dissertation focused on the pathogenesis of an avian condition termed transient paralysis. Susceptibility to this disease is linked to the avian major histocompatibility complex and occurs in certain in-bred lines of chickens after either spontaneous or experimental infection with the Marek’s disease herpesvirus. Aspects of disease pathogenesis are analogous to experimental allergic encephalitis and multiple sclerosis. My studies defined the role that brain edema plays in the onset and, with resolution of the edema, reversal of the clinical signs of transient paralysis. For the past 35 years, I have studied a spontaneous canine disease termed golden retriever muscular dystrophy (GRMD), which serves as an animal model for Duchenne muscular dystrophy (DMD) of humans. Both conditions are X-linked, occurring due to mutations in the DMD gene, which codes for the protein dystrophin. Our research has defined key clinical and pathologic features of GRMD to both better understand disease pathogenesis and to also utilize these parameters in assessing treatment efficacy. In recent years, we have studied various treatments (cell, molecular, and pharmacologic approaches) in affected dogs. Results of these preclinical studies should guide use of similar treatment strategies in DMD patients. This has come to fruition, as GRMD studies on the use of AAV-micro-dystrophin gene constructs have led to human DMD clinical trials. Our studies have been supported principally by the National Institutes of Health (NIH) and Muscular Dystrophy Association (MDA).

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