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CURRICULUM VITAE

Gary W. Hoyle PERSONAL INFORMATION Address: Department of Environmental and Occupational Health Sciences School of Public Health and Information Sciences University of Louisville 701 HSC-A 319 Abraham Flexner Way Louisville, KY 40202 Telephone: 502-852-7337 FAX: 502-852-7889 Email address Gary.Hoyle@louisville.edu Date of birth: July 17, 1961 Place of birth: McMinnville, OR Citizenship USA EDUCATION Johns Hopkins University Baltimore, Maryland B.A. in Natural Sciences (1982) Undergraduate Research Advisors: Dr. Saul Roseman Dr. Robert Maier Duke University Durham, North Carolina Ph.D. in Biochemistry (1988) Advisor: Dr. Robert L. Hill Dissertation Title: Isolation, characterization, and expression of the gene encoding a carbohydrate binding protein unique to rat Kupffer cells University of Pennsylvania Philadelphia, Pennsylvania Postdoctoral fellow (1988-1993) Advisor: Dr. Ralph L. Brinster ACADEMIC POSITIONS Undergraduate research intern (1979-1980), Johns Hopkins University, Department of Biology. Laboratory of Dr. Robert Maier. Undergraduate research intern (1981-1982), Johns Hopkins University, Department of Biology, Baltimore, Maryland. Laboratory of Dr. Saul Roseman. Graduate student (1982-1988), Duke University Medical Center, Department of Biochemistry, Durham, North Carolina. Laboratory of Dr. Robert L. Hill.

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Postdoctoral fellow (1988-1993), University of Pennsylvania, School of Veterinary Medicine, Department of Animal Biology, Philadelphia, Pennsylvania. Laboratory of Dr. Ralph L. Brinster. Assistant Professor (1993-1999), Tulane University Medical Center, Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, New Orleans, Louisiana. Adjunct Assistant Professor (1993-1999), Tulane University Medical Center, Department of Pathology and Laboratory Medicine, New Orleans, Louisiana. Associate Professor (1999-2007), Tulane University Health Sciences Center, Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, New Orleans, Louisiana. Professor (2007-present), University of Louisville, School of Public Health and Information Sciences, Department of Environmental and Occupational Health Sciences, Louisville, Kentucky. Professor (2008-present), University of Louisville, School of Medicine, Department of Biochemistry and Molecular Biology (joint appointment), Louisville, Kentucky. PUBLICATIONS Peer-Reviewed Research Articles 1. Hoyle, G. W., and Hill, R. L. (1988). Molecular cloning and sequencing of a cDNA for a carbohydrate binding receptor unique to rat Kupffer cells. J. Biol. Chem. 263:7487-7492. 2. Hoyle, G. W., and Hill, R. L. (1991). Structure of the gene for a carbohydrate-binding receptor unique to rat Kupffer cells. J. Biol. Chem. 266:1850-1857. 3. Mercer, E. H., Hoyle, G. W., Kapur, R. P., Brinster, R. L., and Palmiter, R. D. (1991). The dopamine ß-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron 7:703-716. 4. Kapur, R. P., Hoyle, G. W., Mercer, E. H., Brinster, R. L., and Palmiter, R. D. (1991). Some neuronal populations express human dopamine ß-hydroxylase-lacZ transgenes transiently during embryonic development. Neuron 7:717-727. 5. Tiemeyer, M., Greene, J. D., Brandley, B. K., Hoyle, G. W., Ishihara. M., Hill R. L., and Swiedler, S. J. (1992). The binding specificity of normal and variant rat Kupffer cell (lectin) receptors expressed in COS cells. J. Biol. Chem. 267:12252-12257. 6. Cadd, G. C., Hoyle, G. W., Quaife, C. J., Marck, B., Matsumoto, A. M., Brinster, R. L., and Palmiter, R. D. (1992). Alteration of neurotransmitter phenotype in noradrenergic neurons of transgenic mice. Mol. Endocrinol. 6:1951-1960.

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7. Hoyle, G. W., Mercer, E. H., Palmiter, R. D., and Brinster, R. L. (1993). Expression of NGF in sympathetic neurons leads to excessive axon outgrowth from ganglia but decreased terminal innervation within tissues. Neuron 10:1019-1034. 8. Hoyle, G. W., Mercer, E. H., Palmiter, R. D., and Brinster, R. L. (1994). Cell-specific expression from the human dopamine ß-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J. Neurosci. 14: 2455-2463. 9. Bamber, B. A., Masters, B. A., Hoyle, G. W., Brinster, R. L., and Palmiter, R. D. (1994). Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice. Proc. Natl. Acad. Sci. USA 91:7839-7843. PMC44499. 10. Quaife, C. J., Hoyle, G. W., Froelick, G., Baetge, E., Behringer, R. R., Brinster, R. L., and Palmiter, R. D. (1994). Visualization and ablation of phenylethanolamine N-methyltransferase producing cells in transgenic mice. Transgenic Res. 3:388-400. 11. Hoyle, G. W., Graham, R. M., Finkelstein, J. A., Nguyen, K., Gozal, D., and Friedman, M. (1998). Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor. Am. J. Resp. Cell Mol. Biol. 18:149-157. 12. Morris, G. F., Hoyle, G. W., Athas, G. B., Lei, W.-H., Xu, J., Morris, C. B., and Friedman, M. (1998). Lung-specific expression in mice of a dominant-negative mutant form of the p53 tumor suppressor protein. J. La. State Med. Soc. 150:179-185. 13. Lasky, J. A., Ortiz, L. A., Tonthat, B., Hoyle, G. W., Corti, M., Athas, G., Lungarella, G., Brody, A. R., and Friedman, M. (1998). Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 275:L365-371. 14. Ortiz, L., Lasky, J., Hamilton, R. F., Holian, A., Hoyle, G. W., Banks, W., Peschon, J. J., Brody, A. R., Lungarella, G., and Friedman, M. (1998). Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice. Exp. Lung Res. 24:721-743. 15. Ortiz, L. A., Moroz, K., Liu, J.-Y., Hoyle, G. W., Hammond, T., Hamilton, R. F., Holian, A., Banks, W., Brody, A. R., and Friedman, M. (1998). Alveolar macrophage apoptosis and TNF-α correlate with murine response to bleomycin. Am. J. Physiol. Lung Cell. Mol. Physiol. 275:L1208-1218. 16. Liu, J.-Y., Brass, D. M., Hoyle, G. W., and Brody, A. R. (1998). TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am. J. Pathol. 153:1839-1847. PMC1866331. 17. Liu, J.-Y., Lei, W.-H., Brody, A. R., and Hoyle, G. W. (1998). Investigation of tissue preparation conditions for nonradioactive in situ hybridization: Localization of transforming growth factor-α message in rat kidney. Histochem. J. 30:793-798. 18. Brass, D. M., Hoyle, G. W., Poovey, H. G., Liu, J.-Y., and Brody, A. R. (1999). Reduced tumor necrosis factor-α and transforming growth factor-ß1 expression in the

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lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure. Am. J. Pathol. 154:853-862. PMC 1866420. 19. Hoyle, G. W., Li, J., Finkelstein, J. B., Eisenberg, T., Liu, J.-Y., Lasky, J., Athas, G., Morris, G., and Brody, A. R. (1999). Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. Am. J. Pathol. 154:1763-1775. PMC1866633. 20. Mendoza, T., Nelson, A. B., Ghosh, S., Morris, C. B., Hoyle, G. W., Brody, A. R., Friedman, M., and Morris, G. F. (2000). Long term survival of mice that express dominant negative p53 in the lung. J. La. State Med. Soc. 152:181-189. 21. Braun, A., Quarcoo, D., Schulte-Herbruggen, O., Lommatzsch, M., Hoyle, G., and Renz, H. (2001). Nerve growth factor induces airway hyperresponsiveness in mice. Int. Arch. Allergy Immunol. 124:205-207. 22. Graham, R. M., Friedman, M., and Hoyle, G. W.. (2001). Sensory nerves promote ozone-induced lung inflammation in mice. Am. J. Resp. Crit. Care Med. 164:307-313. 23. Li, J., and Hoyle, G. W. (2001). Overexpression of PDGF-A in the lung epithelium of transgenic mice produces a lethal phenotype associated with hyperplasia of mesenchymal cells. Dev. Biol. 239:338-349. 24. Li, J., Ortiz, L. A., and Hoyle, G. W. (2002). Lung pathology in platelet-derived growth factor transgenic mice: effects of genetic background and fibrogenic agents. Exp. Lung Res. 28:507-522. 25. Ortiz, L. A., Champion, H. C., Lasky, J. A., Gambelli, F., Gozal, E., Hoyle, G. W., Beasley, M. B., Hyman, A. L., Friedman, M., and Kadowitz, P. J. (2002). Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-κB and AP-1. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L1209-L1221. 26. Ghosh, S., Mendoza, T., Ortiz, L. A., Hoyle, G. W., Fermin, C. D., Brody, A. R., Friedman, M., and Morris, G. F. (2002). Enhanced bleomycin sensitivity of mice expressing dominant-negative p53 in the lung epithelium. Am. J. Resp. Crit. Care Med. 166:890-897. 27. Path, G., Braun, A., Meents, N., Kerzel, S., Quarcoo, D., Raap, U., Hoyle, G. W., Nockher, W. A., and Renz, H. (2002). Augmentation of allergic early-phase reaction by nerve growth factor. Am. J. Resp. Crit. Care Med. 166:818-826. 28. Lee, C.-T., Poovey, H. G., Rando, R. J., Friedman, M., and Hoyle, G. W. (2003). An HDI polyisocyanate aerosol exposure system for large-scale animal experiments. Am. Ind. Hyg. Assoc. J. 64:439-444. 29. Lee, C.-T., Friedman, M., Poovey, H. G., Ie, S. R., Rando, R. J., and Hoyle, G. W. (2003). Pulmonary toxicity of hexamethylene diisocyanate aerosols in mice. Toxicol. Appl. Pharmacol. 188:154-164.

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30. Zhuo, Y., Hoyle G. W., Zhang, J., Morris, G., and Lasky, J. A. (2003). A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function. Biochem. Biophys. Res. Commun. 308:126-132. 31. Vuillemenot, B. R., Rodriguez, J. F., and Hoyle, G. W. (2004). Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing TNF-α. Am. J. Resp. Cell Mol. Biol. 30:438-448. 32. Henson, M. C., Swan, K. F., Edwards, D. E., Hoyle, G. W., Purcell, J., and Castracane, V. D. (2004). Leptin receptor expression in fetal lung is enhanced in late gestation in the baboon: a model for human pregnancy. Reproduction 127:87-94. 33. Quarcoo, D., Schulte-Herbruggen, O., Lommatzsch, M., Schierhorn, K., Hoyle, G. W., Renz, H., and Braun, A. (2004). Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin. Exp. Allergy 34:1146-1151. 34. Curiel, T. J., Cheng, P., Mottram, P., Alvarez, X., Moons, L., Evdemon-Hogan, M., Wei, .S, Zou, L., Kryczek, I., Hoyle, G., Lackner, A., Carmeliet, and P., Zou, W. (2004). Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res. 64:5535-5538. 35. Li, J., Poovey, H. G., Rodriguez, J. F., Brody, A. R., and Hoyle, G. W. (2004). Effect of platelet-derived growth factor on the development and persistence of asbestos-induced fibroproliferative lung disease. J. Environ. Path. Toxicol. Oncol. 23:253-266. 36. Lee, C.-T., Ylostalo, J., Friedman, M., and Hoyle, G. W. (2005). Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure. Toxicol. Appl. Pharmacol. 205:53-64. 37. Zhou, Y., Hoyle, G. W., and Lasky, J. A. (2006). Overexpression of PDGF-C using a lung-specific promoter results in abnormal lung development. Transgenic Res. 15:543-555. 38. Grad, I., McKee, T. A., Ludwig, S. M., Hoyle, G. W., Ruiz, P., Wurst, W., Floss, T., Miller, C. A., III, and Picard., D. (2006). The Hsp90 co-chaperone p23 is essential for perinatal survival. Mol. Cell. Biol. 26:8976-8983. PMC1636834. 39. Williams, R., Zou, Y., and Hoyle, G. W. (2007). Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-κB via a Gq-dependent pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 292:L430-L437. http://ajplung.physiology.org/content/292/2/L430.long 40. Zwezdaryk, K. J., Coffelt, S. B., Figueroa, Y. G., Liu, J., Phinney, D. G., LaMarca, H. L., Florez, L., Morris, C. B., Hoyle, G. W., and Scandurro, A. B. (2007). Erythropoietin, a hypoxia-regulated factor, elicits a pro-angiogenic program in human mesenchymal cells. Exp. Hematol. 35:640-652. http://www.sciencedirect.com/science/article/pii/S0301472X07000574

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41. Lee, C.-T., Poovey, H. G., Rando, R. J., and Hoyle, G. W. (2007). Neuronal modulation of lung injury induced by polymeric hexamethylene diisocyanate in mice. Toxicol. Appl. Pharmacol. 224:19-28. http://www.sciencedirect.com/science/article/pii/S0041008X07002736 42. Fattman, C., Gambelli, F., Hoyle, G., Pitt, B., and Ortiz, L. (2008). Epithelial expression of TIMP1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 294:L572-L581. http://ajplung.physiology.org/content/294/3/L572.long 43. Tian, X., Tao, H., Brisolara, J., Chen, J., Rando, R. J., and Hoyle, G. W. (2008). Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal. Toxicol. 20:783-793. http://informahealthcare.com/doi/abs/10.1080/08958370802007841%20 44. Chang, W., Chen, J., Schlueter, C. F., and Hoyle, G. W. (2009). Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. Exp. Lung Res. 35:324-343. PMC2694966. http://informahealthcare.com/doi/abs/10.1080/01902140802712738 45. Di Giuseppe, M., Gambelli, F., Hoyle G. W., Lungarella, G., Studer S. M., Richards, T., Yousem, S., McCurry, K., Dauber, J., Kaminsky, N., Leikauf, G., and Ortiz, L.A. (2009). Systemic inhibition of NF-κB activation protects from silicosis. PLoS ONE 4(5): e5689. doi:10.1371/journal.pone.0005689. PMC2682759. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005689 46. Hoyle, G. W., Hoyle, C. I., Chen, J., Chang, W., Williams, R. W., and Rando, R. J. (2010). Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 298:L830-L836. PMC2886612. http://ajplung.physiology.org/content/298/6/L830.long 47. Hoyle, G. W., Chang, W., Chen, J., Schlueter, C. F., and Rando, R. J. (2010). Deviations from Haber's law for multiple measures of acute lung injury in chlorine-exposed mice. Toxicol. Sci. 118:696-703. PMC2984531. http://toxsci.oxfordjournals.org/content/118/2/696.long 48. Xiang, S., Mao, L., Yuan, L., Duplessis, T., Jones, F., Hoyle, G. W., Frasch, T., Dauchy, R., Blask, D. E., Chakravarty, G., and Hill, S. M. (2012). Impaired mouse mammary gland growth and development is mediated by melatonin and its MT1 G protein-coupled receptor via repression of ERα, Akt1, and Stat5. Journal of Pineal Research 53:307-318. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2012.01000.x/abstract 49. Musah, S., DeJarnett, N., and Hoyle, G. W. (2012). Tumor necrosis factor-α mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter. Toxicol. 299:125-132. http://www.sciencedirect.com/science/article/pii/S0300483X12001709 50. Chang, W., Chen, J., Schlueter, C. F., Rando, R. J., Pathak, Y. V., and Hoyle, G. W. (2012). Inhibition of chlorine-induced lung injury by the type 4

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phosphodiesterase inhibitor rolipram. Toxicol. Appl. Pharmacol. 263:251-258. PMC3422440. http://www.sciencedirect.com/science/article/pii/S0041008X12002761 51. Musah, S., Chen, J., and Hoyle, G. W. (2012). Repair of tracheal epithelium by basal cells after chlorine-induced injury. Respir. Res. 13:107. PMC3544626. http://respiratory-research.com/content/13/1/107 52. Mo, Y., Chen, J., Schlueter, C. F., and Hoyle, G. W. (2013). Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304:L92-L102. PMC3543638. http://ajplung.physiology.org/content/304/2/L92.long 53. Chen, J., Mo, Y., Schlueter, C. F., and Hoyle, G. W. (2013). Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 272:408-413. http://www.sciencedirect.com/science/article/pii/S0041008X13002822 Reviews, chapters, and proceedings 1. Hoyle, G. W., and Hill, R. L. (1986). The molecular cloning of a cDNA encoding a rat macrophage receptor for oligosaccharides. In Contemporary Themes in Biochemistry: Proceedings of the 4th Federation of Asian and Oceanic Biochemists Congress (Kon, O. L., et al., eds.), pp 284-285, Cambridge University Press, Cambridge. 2. Mercer, E. H., Hoyle, G. W., Kapur, R. P., Quaife, C. J., Brinster, R. L., and Palmiter, R. D. (1991). Use of the dopamine ß-hydroxylase and phenylethanolamine N-methyltransferase gene promoters for expression of transgenes in mice. In Neurotransmitter Regulation of Gene Transcription: Fidia Research Foundation Symposium Series, vol. 7, (Costa, E., and Joh, T. H., eds.), pp 57-67, Thieme Medical Publishers, New York. 3. Hoyle, G.W., and Brody, A. R. (1996). Gene expression in rodent models of environmental lung disease. Ann. N.Y. Acad. Sci. 796:162-172. 4. Brody, A. R., Hoyle, G., Liu, J.-Y., and Brass, D. (1999). Reduced growth factor expression in mice resistant to developing fibroproliferative lesions after lung injury. Chest 116:97S. 5. Hoyle, G. W., and Brody, A. R. (2001). IL-9 and lung fibrosis: A Th2 good guy? Am. J. Resp. Cell Mol. Biol. 24:365-367. 6. Nelson, A., Mendoza, T., Hoyle, G. W., Brody, A. R., Fermin, C., and Morris, G. F. (2001). Enhancement of fibrogenesis by the p53 tumor suppressor protein in asbestos-exposed rodents. Chest 120:33S-34S. 7. Hoyle, G. W. (2003). Neurotrophins and lung disease. Cytokine Growth Factor Rev. 14:551-558.

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8. Hoyle, G. W. (2010). Mitigation of chlorine lung injury by increasing cyclic AMP levels. Proc. Am. Thorac. Soc. 7:284-289. PMC3136965. http://pats.atsjournals.org/content/7/4/284.long GRANT SUPPORT Active As Principal Investigator 8/22/11-5/31/16 National Institutes of Health U01 ES015673 “Novel therapies for chlorine-induced lung injury” $1,906,820 direct costs all years (Principal Investigator, Gary Hoyle) 9/25/12-6/30/17 National Institutes of Health U01 ES022564 “Countermeasures for chlorine-induced airway fibrosis” $1,233,397 direct costs all years (Principal Investigator, Gary Hoyle) As Co-Investigator 9/24/13-8/31/15 National Institutes of Health R21 ES024030 “Novel treatments of acrolein-induced cardiotoxicity” $500,000 direct costs all years (Principal Investigator, Daniel Conklin) Completed As Principal Investigator 7/1/94-6/30/95 National Institute of Environmental Health Sciences Center Development Grant Pilot Project, "Transgenic mouse model for interstitial pulmonary fibrosis" $30,000 direct costs (Principal Investigator, Gary Hoyle) 7/1/95-3/31/96 National Institute of Environmental Health Sciences Center Development Grant Pilot Project, "Platelet-derived growth factor and lung fibrosis" $18,000 direct costs (Principal Investigator, Gary Hoyle) 7/1/95-6/30/96 Department of Defense Bioenvironmental Research Program "Molecular mechanism of lung injury induced by volatile organic compounds" $100,824 direct costs (Principal Investigator, Gary Hoyle) 5/1/96-4/30/02 National Institutes of Health 1 R29 AI39023, "Neurogenic inflammation in asthma and ozone lung injury," $349,028 direct costs all years (Principal Investigator, Gary Hoyle) 7/1/96-6/30/97 Department of Defense Bioenvironmental Research Program, "Molecular mechanism of lung injury induced by volatile organic compounds" $72,848 direct costs (Principal Investigator, Gary Hoyle) 12/1/96-11/30/01 National Institutes of Health 1 R01 HL58610, "Pulmonary fibrosis in PDGF transgenic mice" $683,714 direct costs all years (Principal Investigator, Gary Hoyle)

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5/1/98-4/30/99 Department of Defense, Defense Special Weapons Agency DWSA 01-97-1-0028, “Tachykinins and neurokinin receptors in environmental lung injury” $118,452 direct costs (Principal Investigator, Gary Hoyle) 5/1/99-4/30/00 Department of Defense, Defense Special Weapons Agency DWSA 01-97-1-0028, “Tachykinins and neurokinin receptors in environmental lung injury” $118,519 direct costs (Principal Investigator, Gary Hoyle) 1/1/03-12/31/06 U. S. Environmental Protection Agency R-83068501, “Neurokinin receptors and environmental lung injury” $571,249 direct costs all years (Principal Investigator, Gary Hoyle) 1/1/02-12/31/06 Louisiana Millennium Trust Health Excellence Fund BOR-035 Project 2, “Neurotrophins and asthma” $574,110 direct costs all years (Project Leader, Gary Hoyle) 1/1/02-12/31/06 Louisiana Millennium Trust Health Excellence Fund BOR-035 Project 3, “Mechanisms of TNF-induced emphysema” $604,961 direct costs all years (Project Leader, Gary Hoyle) 5/1/07-3/7/09 Sepracor, Inc. "Levalbuterol and acute lung injury" $55,851 direct costs all years (Principal Investigator, Gary Hoyle) 9/29/06-8/21/11 National Institutes of Health U01 ES015673 “Novel therapies for chlorine-induced lung injury” $1,352,045 direct costs all years (Principal Investigator, Gary Hoyle) 6/1/09-5/31/10 National Institutes of Health Supplement to U01 ES015673 “Novel therapies for chlorine-induced lung injury” $85,117 direct costs (Principal Investigator, Gary Hoyle) 9/23/10-8/31/13 National Institutes of Health R21 ES020123 "Repair of airway epithelium following chlorine lung injury" $355,457 direct costs all years (Principal Investigator, Gary Hoyle) As Co-Investigator 6/1/94-5/31/95 Louisiana Stimulus for Excellence in Research, National Science Foundation EPSCoR Program, "Molecular mechanisms of environmental lung disease $65,336 direct costs (Principal Investigator, Arnold Brody) 7/1/94-6/30/95 Department of Defense Bioenvironmental Research Program, "Radiation-induced lung injury and DNA repair in p53-deficient mice" $153,003 total costs (Principal Investigator, Gilbert Morris) 7/1/95-6/30/96 Department of Defense Bioenvironmental Research Program, "Radiation-induced lung injury and DNA repair in p53-deficient mice" $99,338 direct costs (Principal Investigator, Gilbert Morris)

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7/1/96-6/30/97 Department of Defense Bioenvironmental Research Program, "Radiation-induced lung injury and DNA repair in p53-deficient mice" $72,848 direct costs (Principal Investigator, Gilbert Morris) 7/1/96-6/30/97 Louisiana Cancer and Lung Trust Fund, "A mouse model of lung cancer," $35,599 direct costs (Principal Investigator, Gilbert Morris) 9/1/96-5/31/97 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $12,000 direct costs (Awardee, Regina Graham) 9/1/97-5/31/98 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $12,000 direct costs (Awardee, Regina Graham) 9/30/96-9/29/98 National Institutes of Health R03, "Molecular mechanisms of lung injury and repair" $50,000 direct costs all years (Principal Investigator, Gilbert Morris) 12/1/96-11/30/99 Wetmore Foundation, "Molecular mechanisms of lung cancer" $771,815 direct costs all years (Principal Investigator, Mitchell Friedman) 9/1/98-5/31/99 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $13,200 direct costs (Awardee, Regina Graham) 9/1/98-5/31/99 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $13,200 direct costs (Awardee, Brian Vuillemenot) 7/1/99-1/6/01 Sponsor, American Lung Association Research Training Fellowship Award, $32,500 annual direct costs (Principal Investigator, David Brass) 7/1/99-6/30/00 Sponsor, Tulane Cancer Center Fellowship Award, $6,250 direct costs (Awardee, Jian Li) 9/1/99-5/31/00 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $13,200 direct costs (Awardee, Regina Graham) 9/1/99-5/31/00 Sponsor, Tulane/Xavier Center for Bioenvironmental Research Scholars Program Dissertation Award, $13,200 direct costs (Awardee, Brian Vuillemenot) 9/1/97-8/3/02 National Institutes of Health 1 R01 HL60532, “Epithelial growth factors in environmental lung disease” $929,544 direct costs all years (Principal Investigator, Arnold Brody) 10/1/00-9/30/05 National Institutes of Health 1 R01 ES10046, “Disruption of PDGF signal transduction in pulmonary fibrosis” $750,000 direct costs all years (Principal Investigator, Joseph Lasky) 6/1/01-5/31/05 National Institutes of Health 1 R01 HL63778 “CTGF in lung fibrogenesis” $875,000 direct costs all years (Principal Investigator, Joseph Lasky) 2/4/02-11/30/06 National Institutes of Health R01 ES010859 “TNF-alpha signaling in silica-induced lung fibrosis” $1,000,000 direct costs all years (Principal Investigator, Luis Ortiz)

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5/1/02-4/30/07 National Institutes of Health 1 R01 CA054152 “Neuroendocrine influences on mammary cancer” (Principal Investigator, Steven Hill) 7/1/05-6/30/10 National Institutes of Health P01 HL75161 “Homing and differentiation of adult stem cells to lung” $1,495,627 annual direct costs (Principal Investigator, Darwin Prockop) 4/1/06-3/31/09 National Institutes of Health R01 HL083901 “Role of EBV gene products in the pathogenesis of IPF” $1,000,000 direct costs all years (Principal Investigator, Joseph Lasky) 3/16/09-3/15/10 University of Louisville School of Medicine Collaborative Matching Grant "Inhibition of chemical carcinogenesis by neurokinin 1 receptor signaling" $19,997 direct costs (Principal Investigator, W. Glenn McGregor) 4/1/07-3/31/12 National Institutes of Health R01 HL035812 "Neuroanatomy and molecular biology of airway neurons” $158,182 annual direct costs (Principal Investigator, Richard Dey) 6/1/10-5/31/12 Department of Defense W81XWH-10-1-0398 "Cardiopulmonary damage and air pollution" $487,430 annual direct costs (Principal Investigator, Aruni Bhatnagar) INVITED LECTURES AND SYMPOSIA Wistar Institute, Philadelphia, PA, July, 1993. Department of Pathology, Tulane University Medical Center, New Orleans, LA, August, 1993. Center for Biotechnology, Ohio State University, Columbus, OH, September, 1993. Workshop on Transgenic Model Systems, National Institute of Environmental Health Sciences, Research Triangle Park, NC, March, 1997. Workshop on Transgenic Model Systems, National Institute of Environmental Health Sciences, Research Triangle Park, NC, April, 1998. “Expression of PDGF and TGF-ß1 at sites of lung injury,” presented at the Society of Toxicology 38th Annual Meeting Symposium, “Innovations in Toxicological Sciences: Cytokines: Biology, Gene Regulation and Role in the Pathogenesis of Lung Disease,” New Orleans, LA, March, 1999. “Airway responses controlled by tachykinins,” presented at the American Thoracic Society/National Institute of Environmental Health Sciences Workshop: Lung Disease and the Environment – Where Do We Go From Here?, Toronto, Canada, May, 2000. “Using transgenic, knockout, and resistant mouse strains to understand the mechanisms of particle-induced lung disease,” presented at “New Directions and Needs in Asbestos Research,” Missoula, MT, June, 2002.

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“Positive and negative regulation of inflammation by sensory neuropeptides,” Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, WV, October, 2003. “Regulation of lung inflammation by tachykinins,” Department of Pharmacology, LSU Health Sciences Center, New Orleans, LA, April, 2006. “G proteins and acute lung injury,” Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, January, 2007. “G proteins and acute lung injury,” Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, January, 2007. “Novel therapies for chlorine-induced lung injury,” CounterACT Network Research Symposium, Arlington, VA, April, 2007. “Novel therapies for chlorine-induced lung injury,” CounterACT Network Research Symposium, Washington, D.C., April, 2008. “Countermeasures to chlorine injury: phosphodiesterase inhibitors and ß2-agonists,” 3rd Annual CounterACT Network Research Symposium, Pre-Conference Symposium: Countermeasures Against Injury from Inhaled Chlorine, Washington, DC, April, 2009. “Novel therapies for chlorine-induced lung injury,” 3rd Annual CounterACT Network Research Symposium, Washington, DC, April, 2009. “Novel therapies for chlorine-induced lung injury,” 4th Annual CounterACT Network Research Symposium, San Francisco, CA, June, 2010. “Novel therapies for chlorine-induced lung injury,” 5th Annual CounterACT Network Research Symposium, Washington, DC, June, 2011. “Repair of airway epithelium following chlorine lung injury,” 5th Annual CounterACT Network Research Symposium, Washington, DC, June, 2011. “Medical countermeasures for chlorine exposure,” Biomedical Advanced Research and Development Authority, Washington, D.C., April, 2012. “Novel therapies for chlorine-induced lung injury,” 6th Annual CounterACT Network Research Symposium, San Francisco, CA, June, 2012. “Repair of airway epithelium following chlorine lung injury,” 6th Annual CounterACT Network Research Symposium, San Francisco, CA, June, 2012. “Pathophysiology and treatment of chlorine-induced lung injury,” Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, December, 2012.

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“Mouse models of chlorine inhalation, acute and chronic injuries, and novel therapies,” American Thoracic Society Chemical Inhalation Disasters Workshop, Philadelphia, PA, May, 2013. “Novel therapies for chlorine-induced lung injury,” 7th Annual CounterACT Network Research Symposium, Washington, DC, June, 2013. “Countermeasures for chlorine-induced airway fibrosis,” 7th Annual CounterACT Network Research Symposium, Washington, DC, June, 2013. INTERNAL SEMINARS Tulane University, 1993-2007 Department of Pathology, July, 1994. Department of Biochemistry, March, 1995. Department of Pathology, March, 1995. Department of Medicine, April, 1995. Department of Pharmacology, February, 1996. Department of Pathology, March, 1996. Tulane/LSU Clinical Immunology Seminar Series, May, 1996. Department of Pathology, September, 1996. Department of Pathology, January, 1997. Department of Anatomy, April, 1997. Department of Pediatrics, May, 1997. Department of Pathology, July, 1997. Department of Pathology, October, 1997. Department of Biochemistry, March, 1998. Dean’s Distinguished Faculty Forum, April, 1998. Department of Medicine, March, 1999. Neuroscience Program, October, 1999. Tulane/LSU Clinical Immunology Seminar Series, March, 2000. Department of Pharmacology, March, 2000. Department of Pathology, May, 2000. Department of Cellular and Structural Biology, April, 2001. Department of Pathology, December, 2001. Department of Pathology, April, 2002. Department of Pathology, September, 2002. Department of Medicine, September, 2002. Department of Pathology, February, 2003. Department of Vivarial Sciences, April, 2004. Tulane/LSU Clinical Immunology Seminar Series, December, 2004. Department of Pharmacology, January, 2005 Department of Medicine, January, 2005. Department of Pathology, February, 2005. Department of Structural and Cellular Biology, April, 2005. Human Genetics Program, April, 2006. Department of Environmental Health Sciences, September, 2006.

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Department of Pathology, October, 2006. Department of Pathology, March, 2007. Human Genetics Program, March, 2007. University of Louisville, 2007-present Department of Biochemistry and Molecular Biology, September, 2007. Department of Medicine, Pulmonary Division, September, 2007. School of Public Health and Information Sciences, October, 2007. School of Public Health and Information Sciences, May, 2008 Department of Medicine, Pulmonary Division, November, 2009 Department of Medicine, Pulmonary Division, February, 2011 TECHNOLOGY TRANSFER Research Disclosures "Treatment of chlorine-induced lung injury with the phosphodiesterase inhibitor rolipram," filed with the University of Louisville Office of Technology Transfer, March, 2009. "Treatment of chlorine-induced lung injury with triptolide," filed with the University of Louisville Office of Technology Transfer, March, 2009. “Treatment of airway fibrosis with budesonide,” filed with the University of Louisville Office of Technology Transfer, February, 2014. TEACHING EXPERIENCE Tulane University, 1993-2007 Course director or co-director Co-director, Molecular Medicine (MCBP 705), Spring, 1995. Co-director, Molecular Medicine (MCBP 705), Fall, 1996. Co-director, Molecular Medicine (MCBP 705), Spring, 1999. Director, Molecular and Cellular Biology Workshop (MCBP 710-01), Fall, 1999. Director, Molecular and Cellular Biology Workshop (MCBP 711-01), Spring, 2000. Director, Molecular and Cellular Biology Workshop (MCBP 710-01), Fall, 2000. Director, Molecular and Cellular Biology Workshop (MCBP 711-01), Spring, 2001. Co-Director, Molecular Medicine (MCBP-705), Spring, 2002.

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Co-Director, Molecular Medicine (MCBP-705), Spring, 2004. Lectures/Other Teaching assistant, Molecular and Cellular Biology Laboratory, Johns Hopkins University, Department of Biology, Spring, 1982. Molecular and Cellular Biology Research Methods (MCBP 712), Tulane University Medical Center, 1994-2007. Department of Pathology Research Workshop, "Transgenic mice and gene knock-out mice," Tulane University Medical Center, June, 1995. Pulmonary Fellows Conference, "Transgenic mouse models of lung disease," Tulane University Medical Center, December, 1996. Methods in Neuroscience 702, "Use of transgenic and gene knockout mice in neuroscience research," Tulane University Medical Center, April, 1997. Pulmonary Fellows Conference, "Animal models of lung injury," Tulane University Medical Center, January, 1998. Methods in Neuroscience 702, "Use of transgenic and gene knockout mice in neuroscience research," Tulane University Medical Center, April 1999. Pulmonary Fellows Conference, "Use of genetically altered mice in the study of pulmonary diseases," Tulane University Medical Center, June, 1999. Pulmonary Fellows Conference, "Use of genetically manipulated mice in pulmonary disease research," Tulane University Medical Center, December, 2000. Methods in Neuroscience 702, "Transgenic and gene targeted mice in neuroscience research," Tulane University Medical Center, April, 2001. Methods in Neuroscience 702, "Transgenic and gene targeted mice in neuroscience research," Tulane University Medical Center, April, 2003. Pulmonary Fellows Conference, "Mechanisms of TNF-induced emphysema," Tulane University Health Sciences Center, April, 2004. Pediatric Pulmonary Conference, “Use of transgenic and gene knockout mice in lung disease research,” Tulane University Health Sciences Center, January, 2005. Methods in Neuroscience 702, "Transgenic and gene targeted mice in neuroscience research," Tulane University Health Sciences Center, March, 2005. Pulmonary Fellows Conference, “G proteins and acute lung injury,” Tulane University Health Sciences Center, April, 2006. University of Louisville, 2007-present Participation as instructor/lecturer

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Seminar in Environmental Health PHEH751/752, Spring 2008, Fall 2008, Spring 2009, Fall 2009, Spring 2010, Fall 2010, Spring 2011, Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014. Occupational Safety and Health PHEH 610, School of Public Health and Information Sciences, “Laboratory models of environmental and occupational lung disease,” 2007, 2008, 2009, 2010, 2011; “Pulmonary toxicology”, 2013. Molecular Mechanisms of Toxicology PHTX 661, School of Medicine, “Chemical-induced pulmonary toxicology,” 2008, 2009, 2010, 2011, 2012, 2013. Molecular Mechanisms of Toxicology PHTX 661, School of Medicine, “Transgenic and knockout mice in toxicology research,” 2009, 2010, 2011, 2012, 2013. Independent Study, Environmental and Occupational Health PHEH753, School of Public Health and Information Sciences, Summer 2010. Advanced Environmental Sciences PHEH 651, Pulmonary Toxicology module, Spring 2014 TRAINING OF STUDENTS/FELLOWS Graduate Students/Thesis Advisor/Dissertation Committee Chair Regina Graham, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1995-2001. Dissertation title: “Neuronal modulation of ozone-induced lung injury.” Jian Li, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1997-2000. Dissertation title: “The role of PDGF in pulmonary fibrosis and lung development.” Present position, Pulmonologist, private practice. Brian Vuillemenot, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1997-2001. Dissertation title: “Inducible expression of a TNF- transgene in the murine lung.” Present position, Staff Scientist, Biomarin Pharmaceuticals. Chun-Ting Lee (Co-advisor), Interdisciplinary Graduate Program in Molecular and Cellular Toxicology, Tulane University, 1998-2002. Dissertation title: “Mechanisms of polyisocyanate-induced lung disease.” Present position, Staff Scientist, National Institute on Drug Abuse. Latoya Johnson, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 2002-2006. Dissertation title: “Regulation of cigarette smoke-induced lung injury by nerve growth factor, sensory nerves and substance P.” Patricia Kimani, Department of Structural and Cellular Biology, Tulane University, 2004-2006.

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Sadiatu Musah, Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 2009-2013. Dissertation title: “Repair of airway epithelium after chlorine-induced injury.” Graduate Students/Dissertation Committee Member Bo Wang, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1995-1996. Jin Xu, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1995-1998. David Brass, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1995-1998. Debbie Sullivan, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 1997-1999. Ajita Narayan, Department of Biochemistry, Tulane University, 1998-2000. Bich Duong, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 2000-2004. Sathish Srinivasan, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, 2001-2003. Sarah Ludwig, Biomedical Sciences Graduate Program, Tulane University, 2006-2007. Patricia Kimani, Molecular and Cellular Biology Program, University of Iowa, 2006-2009. Graduate Students/Laboratory Rotation Advisor Bo Wang, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 1994. Gina Graham, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 1995. David Brass, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 1995. Brian Vuillemenot, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 1997. Jian Li, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 1997. Marc Cox, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Fall 1999. Bich Duong, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 2000.

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Dien Pham, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Tulane University, Spring 2002. Mitterand Nformi Massa, Department of Biochemistry, University of Louisville, Fall 2008 Sadiatu Musah, Department of Environmental and Occupational Health Sciences, University of Louisville, Spring 2009 Natasha DeJarnett, Department of Environmental and Occupational Health Sciences, University of Louisville, Fall 2009 Lorena Canales, Department of Environmental and Occupational Health Sciences, University of Louisville, Summer 2010. Shannon Scroggins, Department of Environmental and Occupational Health Sciences, University of Louisville, Fall 2012. Kendall Stocke, Department of Environmental and Occupational Health Sciences, University of Louisville, Spring 2014 Fellows/Research Advisor Mark McCarthy, M.D., Pulmonary Fellow, Tulane University, 1994-1996. Luis Vasquez, M.D., Pulmonary Fellow, Tulane University, 1997. Susanti Ie, M.D., Pulmonary Fellow, Tulane University, 1998-2000. Present position, Assistant Professor, Virginia Tech Carilion School of Medicine. David Brass, Ph.D., Postdoctoral Fellow, Tulane University, 1998-2000. Present position, Research Assistant Professor, Duke University Medical Center. Juan Carlos Armstrong, M.D., Pulmonary Fellow, Tulane University, 1999. Miroslav Sarac, Ph.D., Postdoctoral Fellow, Tulane University, 2003-2004. Present position, Assistant Professor, College of Pharmacy, Xavier University of Louisiana. Ron Williams, M.D., NIH Postdoctoral Trainee, Tulane University, 2004-2006. Present position, Assistant Professor, Virginia Commonwealth University Medical Center. Jaime Palomino, M.D., Pulmonary Fellow, Tulane University, 2006-2007. Present position, Assistant Professor, Tulane University. Xiaohua Tian, Ph.D., Postdoctoral Fellow, Tulane University, 2006-2007. Wei-Yuan Chang, Ph.D., Postdoctoral Fellow, University of Louisville, 2007-2010. Present position, Reviewer, Taiwan Center for Drug Evaluation Yiqun Mo, Ph.D., Research Associate, University of Louisville, 2011-present. Medical Students/Research Advisor

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Todd Eisenberg, Tulane University, 1997-1998. HONORS, AWARDS, AND SERVICE Manuscript reviewer American Journal of Pathology American Journal of Physiology, Lung Cellular and Molecular Physiology American Journal of Respiratory and Critical Care Medicine American Journal of Respiratory Cell and Molecular Biology Analytical Biochemistry BMC Genomics Clinica Chimica Acta Environmental Science & Technology European Respiratory Journal Experimental Biology and Medicine Experimental Lung Research Free Radical Biology & Medicine Growth Factors Hepatology Inhalation Toxicology International Journal of Biochemistry & Cell Biology Journal of Aerosol Medicine and Pulmonary Drug Delivery Journal of Biological Chemistry The Journal of Histochemistry and Cytochemistry Journal of Laboratory and Clinical Medicine Peptides PLoS One Proceedings of the National Academy of Sciences USA Respiratory Research Thorax Toxicological Sciences Toxicology and Applied Pharmacology Toxicology Mechanisms and Methods Transgenic Research NIH study sections National Institute of Allergy and Infectious Diseases Special Emphasis Panel: Asthma, Allergic and Immunologic Diseases Cooperative Research Centers, June 1997. National Heart, Lung, and Blood Institute Special Emphasis Panel: Airway Remodeling and Repair in Asthma, June 1999. National Institute of Neurological Diseases and Stroke Special Emphasis Panel: Countermeasures against Chemical Threats (U54), August 2006. NIH Lung Injury, Repair, and Remodeling (LIRR) Study Section, February 2008. NIH Lung Injury, Repair, and Remodeling (LIRR) Study Section, October 2010.

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ZRG1 CVRS-J (02) Member conflict: Airway Smooth Muscle, Asthma, and Airway Cell Biology, January 2012 ZRG1 MDCN-B 55 Countermeasures Against Chemical Threats (R21), July 2012 NIH Lung Injury, Repair, and Remodeling (LIRR) Study Section, February 2013. Other grant reviews Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical and Biological Defense, November 2008. Israel Science Foundation, March 2012. National Meetings Co-Chair, Mini-Symposium, “Plasticity of Airway Sensory Nerves,” American Thoracic Society International Conference, Toronto, Canada, May 2000. Facilitator, Thematic Poster Session, “Mechanisms of Lung Injury and Repair,” American Thoracic Society International Conference, Toronto, Canada, May 2008 Program Committee, Pre-Conference Symposium, Countermeasures against Injury from Inhaled Chlorine, 3rd Annual CounterACT Network Research Symposium, Washington, DC, April 2009. Internal Committees and Service Tulane University, 1993-2007 Tulane University Health Sciences Center Institutional Animal Care and Use Committee (IACUC), 1997-2007. Tulane University Health Sciences Center Institutional Biosafety Committee, 2004-2007. Coordinator, Department of Medicine Research Conference, 2001-2005. Department of Medicine Promotions and Tenure Committee, 2002-2004, 2006-2007. Judge, Tulane Health Sciences Research Day, 2001, 2003, 2004, 2007. Molecular and Cellular Biology Task Force, Tulane University, 1995. Selection Committee for Schaffer Award for Excellent in Research, Tulane University, 1998. University of Louisville, 2007-present Promotion, Appointment, and Tenure Committee, School of Public Health and Information Sciences, 2008-present (Chair, 2011-present). MPH Admissions Committee, School of Public Health and Information Sciences, 2008.

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Screening Committee for President’s Distinguished Faculty Awards, Outstanding Scholarship, Research, and Creative Activity Award, 2008, 2009. Judge, Research! Louisville, 2008-2010, 2012-2013. Provided lab tour and presentation for middle school students attending Beaker Buster Camp, 2009 Faculty Research Advisory Council, 2012-present. Awards Dean’s Distinguished Faculty Forum, Tulane University, 1998. University Scholar, University of Louisville, 2007-present.